Human CYP4F12 genetic polymorphism: identification and functional characterization of seven variant allozymesChristelle Cauffiez
Equipe d accueil 2679, Faculte de Medecine de Lille, Pole Recherche, Lille, France
Biochem Pharmacol 68:2417-25. 2004
..These data on CYP4F12 genetic polymorphism provide tools for further studies of association with pathological processes involving an inflammatory component and with variations in anti-histaminic drug response...
- First report of a genetic polymorphism of the cytochrome P450 3A43 (CYP3A43) gene: identification of a loss-of-function variant
Christelle Cauffiez
Equipe d accueil 2679, Faculte de Medecine de Lille, Pole Recherche, Lille, France
Hum Mutat 23:101. 2004
..14%) for the nucleotide deletion, which suggests that, although the potential significance of this polymorphism remains to be further evaluated, some individuals are deficient for CYP3A43 activity...
- Genetic polymorphism of the human cytochrome CYP2A13 in a French population: implication in lung cancer susceptibility
Christelle Cauffiez
Equipe d accueil 2679, Faculte de Medecine de Lille, Pole Recherche, Lille, France
Biochem Biophys Res Commun 317:662-9. 2004
..9; 95% confidence interval CI=1.9-52.2). This increased risk was not linked to other histological types of lung cancer...
- Molecular analysis of the CYP2F1 gene: identification of a frequent non-functional allelic variant
Gilles Tournel
Equipe d accueil 2679, Faculte de Medecine de Lille, Pole Recherche, Lille, France
Mutat Res 617:79-89. 2007
..However, our preliminary results did not show any evidence that the CYP2F1 genetic polymorphism has implications in the pathogenesis of lung cancer...
- Evidence for a functional genetic polymorphism of the human thiosulfate sulfurtransferase (Rhodanese), a cyanide and H2S detoxification enzyme
Ingrid Billaut-Laden
Equipe d accueil EA2679, Faculte de Medecine, Pole Recherche, Lille, France
Toxicology 225:1-11. 2006
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- Functional characterization of genetic polymorphisms identified in the human cytochrome P450 4F12 (CYP4F12) promoter region
Christelle Cauffiez
Equipe d'accueil 2679, , , Lille, France
Biochem Pharmacol 67:2231-8. 2004
..Both alleles lead to a significant decrease of CYP4F12 gene expression in HepG2 cell line and, therefore, are likely to determine interindividual differences in CYP4F12 gene expression...
Inter-ethnic variability of three functional polymorphisms affecting the IMPDH2 geneAnne Garat
Equipe d accueil 4483, Faculte de Medecine de Lille, Pole Recherche, 1 place de Verdun, 59045 Lille Cedex, France
Mol Biol Rep 38:5185-8. 2011
..This ethnic-related data might contribute to a better understanding of the variability in clinical outcome and/or dose adjustments of drugs that are IMPDH inhibitors such as mycophenolic acid...
- Genetic polymorphism of the human cytochrome P450 CYP4B1: evidence for a non-functional allelic variant
Jean Marc Lo-Guidice
Equipe d accueil 2679, Faculte de Medecine de Lille, Pole Recherche, Lille, France
Pharmacogenetics 12:367-74. 2002
..Given the relatively high frequency and the functional consequences of the CYP4B1*2 allele, associations between CYP4B1 polymorphism and certain pathological processes should be considered...
- CYP3A5 and ABCB1 polymorphisms in donor and recipient: impact on Tacrolimus dose requirements and clinical outcome after renal transplantation
Francois Glowacki
EA4483, Faculte de Medecine, Pole Recherche, Lille, France
Nephrol Dial Transplant 26:3046-50. 2011
..The effect of potentially relevant genetic polymorphisms, CYP3A5 6986A>G and ABCB1 3435C>T, on Tacrolimus pharmacokinetics and graft clinical outcome was investigated in donor and recipient DNA samples from 209 kidney transplant patients...
- Evidence for a functional genetic polymorphism of the human mercaptopyruvate sulfurtransferase (MPST), a cyanide detoxification enzyme
Ingrid Billaut-Laden
Equipe d accueil EA2679, Faculte de Medecine, Pole Recherche, 1 place de Verdun, 59045 Lille Cedex, France
Toxicol Lett 165:101-11. 2006
..This work constitutes the first report of the existence of a functional genetic polymorphism affecting MPST and should be of great help to investigate certain disorders such as MCDU...
- In vitro characterization of four novel non-functional variants of the thiopurine S-methyltransferase
Rima Hamdan-Khalil
Equipe d accueil EA2679, Faculte de Medecine, Pole Recherche, Lille, France
Biochem Biophys Res Commun 309:1005-10. 2003
..These findings improve our knowledge of the genetic basis of interindividual variability in TPMT activity and would enhance the efficiency of genotyping methods to predict patients at risk of inadequate responses to thiopurine therapy...
- Genetic polymorphism of CYP2U1, a cytochrome P450 involved in fatty acids hydroxylation
Aurore Devos
EA2679, Faculte de Medecine, Pole Recherche, Universite Lille Nord de France, France
Prostaglandins Leukot Essent Fatty Acids 83:105-10. 2010
..The most frequent mutations, -241T>C (59.7%) and IVS2-17T>C (66.0%), did not seem to alter CYP2U1 lung expression. These results suggest that CYP2U1 exhibits few genetic variations and support a probable role in endogenous processes...
- Genetic polymorphism of CYP4A11 and CYP4A22 genes and in silico insights from comparative 3D modelling in a French population
Christian L Lino Cardenas
Universite Lille Nord de France, Faculte de Medecine de Lille, Lille Cedex, France
Gene 487:10-20. 2011
..These results could be helpful for further investigations of the potential role of CYP4A variants in the genetic susceptibility to cardiovascular diseases in humans such as arterial hypertension...
- Sequence analysis, frequency and ethnic distribution of VNTR polymorphism in the 5'-untranslated region of the human prostacyclin synthase gene (CYP8A1)
Dany Chevalier
EA2679, Faculte de Medecine de Lille, Pĵle Recherche, Lille, France
Prostaglandins Other Lipid Mediat 70:31-7. 2002
..This study represents the first multi-population-based analysis of the frequency and distribution of VNTR polymorphism affecting the CYP8A1 promoter...
- IMPDH2 genetic polymorphism: a promoter single-nucleotide polymorphism disrupts a cyclic adenosine monophosphate responsive element
Anne Garat
EA267, Faculty of Medicine, University Lille Nord de France, Lille, France
Genet Test Mol Biomarkers 13:841-7. 2009
..These results might contribute to a better understanding of the variability in clinical outcome and dose adjustments of certain immunosuppressors that are metabolized through the IMPDH pathway or that are IMPDH inhibitors...
- Influence of cytochrome P450 3A5 (CYP3A5) genetic polymorphism on the pharmacokinetics of the prolonged-release, once-daily formulation of tacrolimus in stable renal transplant recipients
Francois Glowacki
Equipe d accueil 4483, Faculte de Medecine, Pole Recherche, Lille, France
Clin Pharmacokinet 50:451-9. 2011
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- Functional analysis of CYP2D6.31 variant: homology modeling suggests possible disruption of redox partner interaction by Arg440His substitution
Delphine Allorge
EA2679, Faculté de Médecine Pôle Recherche, 59045 Lille, France
Proteins 59:339-46. 2005
..Docking the structure of the FMN domain of human cytochrome P450 reductase to the CYP2D6 model suggests that Arg440 is a key member of a cluster of basic amino acid residues important for reductase binding...
- Evidence for a functional genetic polymorphism of the human retinoic acid-metabolizing enzyme CYP26A1, an enzyme that may be involved in spina bifida
Emmanuel Rat
Equipe d accueil EA2679, Faculte de Medecine, Lille Cedex, France
Birth Defects Res A Clin Mol Teratol 76:491-8. 2006
..As RA is a critical regulator of gene expression during embryonic development, the imbalance between the synthesis and degradation of RA during embryogenesis could contribute to malformations and developmental defects...
Identification of a novel splice-site mutation in the CYP1A2 geneDelphine Allorge
EA 2679, Faculté de Médecine Pôle Recherche, 1 place de Verdun, F 59045 Lille Cedex, France
Br J Clin Pharmacol 56:341-4. 2003
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