Christelle Cauffiez

Summary

Publications

  1. ncbi Human CYP4F12 genetic polymorphism: identification and functional characterization of seven variant allozymes
    Christelle Cauffiez
    Equipe d accueil 2679, Faculte de Medecine de Lille, Pole Recherche, Lille, France
    Biochem Pharmacol 68:2417-25. 2004
  2. ncbi First report of a genetic polymorphism of the cytochrome P450 3A43 (CYP3A43) gene: identification of a loss-of-function variant
    Christelle Cauffiez
    Equipe d accueil 2679, Faculte de Medecine de Lille, Pole Recherche, Lille, France
    Hum Mutat 23:101. 2004
  3. ncbi Genetic polymorphism of the human cytochrome CYP2A13 in a French population: implication in lung cancer susceptibility
    Christelle Cauffiez
    Equipe d accueil 2679, Faculte de Medecine de Lille, Pole Recherche, Lille, France
    Biochem Biophys Res Commun 317:662-9. 2004
  4. ncbi Molecular analysis of the CYP2F1 gene: identification of a frequent non-functional allelic variant
    Gilles Tournel
    Equipe d accueil 2679, Faculte de Medecine de Lille, Pole Recherche, Lille, France
    Mutat Res 617:79-89. 2007
  5. ncbi Evidence for a functional genetic polymorphism of the human thiosulfate sulfurtransferase (Rhodanese), a cyanide and H2S detoxification enzyme
    Ingrid Billaut-Laden
    Equipe d accueil EA2679, Faculte de Medecine, Pole Recherche, Lille, France
    Toxicology 225:1-11. 2006
  6. ncbi Functional characterization of genetic polymorphisms identified in the human cytochrome P450 4F12 (CYP4F12) promoter region
    Christelle Cauffiez
    Equipe d accueil 2679, Faculte de Medecine de Lille, Pole Recherche, Lille, France
    Biochem Pharmacol 67:2231-8. 2004
  7. doi Inter-ethnic variability of three functional polymorphisms affecting the IMPDH2 gene
    Anne Garat
    Equipe d accueil 4483, Faculte de Medecine de Lille, Pole Recherche, 1 place de Verdun, 59045 Lille Cedex, France
    Mol Biol Rep 38:5185-8. 2011
  8. doi CYP3A5 and ABCB1 polymorphisms in donor and recipient: impact on Tacrolimus dose requirements and clinical outcome after renal transplantation
    Francois Glowacki
    EA4483, Faculte de Medecine, Pole Recherche, Lille, France
    Nephrol Dial Transplant 26:3046-50. 2011
  9. ncbi Genetic polymorphism of the human cytochrome P450 CYP4B1: evidence for a non-functional allelic variant
    Jean Marc Lo-Guidice
    Equipe d accueil 2679, Faculte de Medecine de Lille, Pole Recherche, Lille, France
    Pharmacogenetics 12:367-74. 2002
  10. ncbi Evidence for a functional genetic polymorphism of the human mercaptopyruvate sulfurtransferase (MPST), a cyanide detoxification enzyme
    Ingrid Billaut-Laden
    Equipe d accueil EA2679, Faculte de Medecine, Pole Recherche, 1 place de Verdun, 59045 Lille Cedex, France
    Toxicol Lett 165:101-11. 2006

Collaborators

  • Delphine Allorge
  • S Quaranta
  • Michel Lhermitte
  • J F Colombel
  • Marc Hazzan
  • Gilles Tournel
  • David Buob
  • Florence Migot-Nabias
  • Brice Marcet
  • Naftali Kaminski
  • Isabelle Stucker
  • C B Eap
  • Jean Louis Gueant
  • Francois Glowacki
  • Jean Marc Lo-Guidice
  • Franck Broly
  • Dany Chevalier
  • Christian Lacks Lino Cardenas
  • Arnaud Lionet
  • Aurore Devos
  • Ingrid Billaut-Laden
  • Anne Garat
  • Cynthia Van der Hauwaert
  • Nicolas Pottier
  • Sebastien Aubert
  • Michael Perrais
  • Emmanuel Rat
  • Grégoire Savary
  • Viviane Gnemmi
  • Rima Hamdan-Khalil
  • Christian Noel
  • Myriam Labalette
  • Christian L Lino Cardenas
  • Francois Provot
  • Aurélie Crunelle-Thibaut
  • Nicole Houdret
  • Bernard Mari
  • Sébastien Bouyé
  • Pascal Barbry
  • Audrey Bouillez
  • Patrice Maboudou
  • Marie Christine Copin
  • Christoph Roderburg
  • Edmone Dewaeles
  • Elisabeth Courcot
  • Jadranka Milosevic
  • Xavier Leroy
  • Tom Luedde
  • Imène Sarah Henaoui
  • Benoit Wallaert
  • Julien Maurizio
  • John Tedrow
  • Laurent Zini
  • Amaury Farce
  • Jean Philippe Hammelin
  • Philippe Chavatte
  • Nicolas Renault
  • Abderraouf Kenani
  • Anne Engels
  • Julie Leclerc
  • Antonio Romano
  • Nicolas Jonckheere
  • Marie Tellier
  • Isabelle Van Seuningen
  • Catherine Spire
  • Jean Luc Gala
  • Christian Libersa
  • Abderaouf Kenani
  • Caroline Lepetit
  • Jean Jacques Lafitte

Detail Information

Publications22

  1. ncbi Human CYP4F12 genetic polymorphism: identification and functional characterization of seven variant allozymes
    Christelle Cauffiez
    Equipe d accueil 2679, Faculte de Medecine de Lille, Pole Recherche, Lille, France
    Biochem Pharmacol 68:2417-25. 2004
    ..These data on CYP4F12 genetic polymorphism provide tools for further studies of association with pathological processes involving an inflammatory component and with variations in anti-histaminic drug response...
  2. ncbi First report of a genetic polymorphism of the cytochrome P450 3A43 (CYP3A43) gene: identification of a loss-of-function variant
    Christelle Cauffiez
    Equipe d accueil 2679, Faculte de Medecine de Lille, Pole Recherche, Lille, France
    Hum Mutat 23:101. 2004
    ..14%) for the nucleotide deletion, which suggests that, although the potential significance of this polymorphism remains to be further evaluated, some individuals are deficient for CYP3A43 activity...
  3. ncbi Genetic polymorphism of the human cytochrome CYP2A13 in a French population: implication in lung cancer susceptibility
    Christelle Cauffiez
    Equipe d accueil 2679, Faculte de Medecine de Lille, Pole Recherche, Lille, France
    Biochem Biophys Res Commun 317:662-9. 2004
    ..9; 95% confidence interval CI=1.9-52.2). This increased risk was not linked to other histological types of lung cancer...
  4. ncbi Molecular analysis of the CYP2F1 gene: identification of a frequent non-functional allelic variant
    Gilles Tournel
    Equipe d accueil 2679, Faculte de Medecine de Lille, Pole Recherche, Lille, France
    Mutat Res 617:79-89. 2007
    ..However, our preliminary results did not show any evidence that the CYP2F1 genetic polymorphism has implications in the pathogenesis of lung cancer...
  5. ncbi Evidence for a functional genetic polymorphism of the human thiosulfate sulfurtransferase (Rhodanese), a cyanide and H2S detoxification enzyme
    Ingrid Billaut-Laden
    Equipe d accueil EA2679, Faculte de Medecine, Pole Recherche, Lille, France
    Toxicology 225:1-11. 2006
    ....
  6. ncbi Functional characterization of genetic polymorphisms identified in the human cytochrome P450 4F12 (CYP4F12) promoter region
    Christelle Cauffiez
    Equipe d accueil 2679, Faculte de Medecine de Lille, Pole Recherche, Lille, France
    Biochem Pharmacol 67:2231-8. 2004
    ..Both alleles lead to a significant decrease of CYP4F12 gene expression in HepG2 cell line and, therefore, are likely to determine interindividual differences in CYP4F12 gene expression...
  7. doi Inter-ethnic variability of three functional polymorphisms affecting the IMPDH2 gene
    Anne Garat
    Equipe d accueil 4483, Faculte de Medecine de Lille, Pole Recherche, 1 place de Verdun, 59045 Lille Cedex, France
    Mol Biol Rep 38:5185-8. 2011
    ..This ethnic-related data might contribute to a better understanding of the variability in clinical outcome and/or dose adjustments of drugs that are IMPDH inhibitors such as mycophenolic acid...
  8. doi CYP3A5 and ABCB1 polymorphisms in donor and recipient: impact on Tacrolimus dose requirements and clinical outcome after renal transplantation
    Francois Glowacki
    EA4483, Faculte de Medecine, Pole Recherche, Lille, France
    Nephrol Dial Transplant 26:3046-50. 2011
    ..The effect of potentially relevant genetic polymorphisms, CYP3A5 6986A>G and ABCB1 3435C>T, on Tacrolimus pharmacokinetics and graft clinical outcome was investigated in donor and recipient DNA samples from 209 kidney transplant patients...
  9. ncbi Genetic polymorphism of the human cytochrome P450 CYP4B1: evidence for a non-functional allelic variant
    Jean Marc Lo-Guidice
    Equipe d accueil 2679, Faculte de Medecine de Lille, Pole Recherche, Lille, France
    Pharmacogenetics 12:367-74. 2002
    ..Given the relatively high frequency and the functional consequences of the CYP4B1*2 allele, associations between CYP4B1 polymorphism and certain pathological processes should be considered...
  10. ncbi Evidence for a functional genetic polymorphism of the human mercaptopyruvate sulfurtransferase (MPST), a cyanide detoxification enzyme
    Ingrid Billaut-Laden
    Equipe d accueil EA2679, Faculte de Medecine, Pole Recherche, 1 place de Verdun, 59045 Lille Cedex, France
    Toxicol Lett 165:101-11. 2006
    ..This work constitutes the first report of the existence of a functional genetic polymorphism affecting MPST and should be of great help to investigate certain disorders such as MCDU...
  11. ncbi In vitro characterization of four novel non-functional variants of the thiopurine S-methyltransferase
    Rima Hamdan-Khalil
    Equipe d accueil EA2679, Faculte de Medecine, Pole Recherche, Lille, France
    Biochem Biophys Res Commun 309:1005-10. 2003
    ..These findings improve our knowledge of the genetic basis of interindividual variability in TPMT activity and would enhance the efficiency of genotyping methods to predict patients at risk of inadequate responses to thiopurine therapy...
  12. doi Genetic polymorphism of CYP4A11 and CYP4A22 genes and in silico insights from comparative 3D modelling in a French population
    Christian L Lino Cardenas
    Universite Lille Nord de France, Faculte de Medecine de Lille, Lille Cedex, France
    Gene 487:10-20. 2011
    ..These results could be helpful for further investigations of the potential role of CYP4A variants in the genetic susceptibility to cardiovascular diseases in humans such as arterial hypertension...
  13. doi Genetic polymorphism of CYP2U1, a cytochrome P450 involved in fatty acids hydroxylation
    Aurore Devos
    EA2679, Faculte de Medecine, Pole Recherche, Universite Lille Nord de France, France
    Prostaglandins Leukot Essent Fatty Acids 83:105-10. 2010
    ..The most frequent mutations, -241T>C (59.7%) and IVS2-17T>C (66.0%), did not seem to alter CYP2U1 lung expression. These results suggest that CYP2U1 exhibits few genetic variations and support a probable role in endogenous processes...
  14. ncbi Sequence analysis, frequency and ethnic distribution of VNTR polymorphism in the 5'-untranslated region of the human prostacyclin synthase gene (CYP8A1)
    Dany Chevalier
    EA2679, Faculte de Medecine de Lille, Pĵle Recherche, Lille, France
    Prostaglandins Other Lipid Mediat 70:31-7. 2002
    ..This study represents the first multi-population-based analysis of the frequency and distribution of VNTR polymorphism affecting the CYP8A1 promoter...
  15. pmc Increased circulating miR-21 levels are associated with kidney fibrosis
    Francois Glowacki
    EA4483, Département de Biochimie et Biologie Moléculaire, Faculté de Médecine H Warembourg, Pole Recherche, Lille, France
    PLoS ONE 8:e58014. 2013
    ..398, p = 0.006). Altogether, these data suggest miR-21 has a key pathogenic role in kidney fibrosis and may represent a novel, predictive and reliable blood marker of kidney fibrosis...
  16. pmc Isolation and characterization of a primary proximal tubular epithelial cell model from human kidney by CD10/CD13 double labeling
    Cynthia Van der Hauwaert
    EA4483, Département de Biochimie et Biologie Moléculaire, Faculte de Medecine de Lille, Pole Recherche, Lille, France
    PLoS ONE 8:e66750. 2013
    ..In conclusion, this study describes a method for establishing a robust renal proximal tubular epithelial cell model suitable for further experimentation. ..
  17. doi IMPDH2 genetic polymorphism: a promoter single-nucleotide polymorphism disrupts a cyclic adenosine monophosphate responsive element
    Anne Garat
    EA267, Faculty of Medicine, University Lille Nord de France, Lille, France
    Genet Test Mol Biomarkers 13:841-7. 2009
    ..These results might contribute to a better understanding of the variability in clinical outcome and dose adjustments of certain immunosuppressors that are metabolized through the IMPDH pathway or that are IMPDH inhibitors...
  18. pmc miR-199a-5p Is Upregulated during Fibrogenic Response to Tissue Injury and Mediates TGFbeta-Induced Lung Fibroblast Activation by Targeting Caveolin-1
    Christian Lacks Lino Cardenas
    EA4483, Faculte de Medecine de Lille, Pole Recherche, Lille, France
    PLoS Genet 9:e1003291. 2013
    ..MiR-199a-5p thus behaves as a major regulator of tissue fibrosis with therapeutic potency to treat fibroproliferative diseases...
  19. doi Influence of cytochrome P450 3A5 (CYP3A5) genetic polymorphism on the pharmacokinetics of the prolonged-release, once-daily formulation of tacrolimus in stable renal transplant recipients
    Francois Glowacki
    Equipe d accueil 4483, Faculte de Medecine, Pole Recherche, Lille, France
    Clin Pharmacokinet 50:451-9. 2011
    ....
  20. ncbi Functional analysis of CYP2D6.31 variant: homology modeling suggests possible disruption of redox partner interaction by Arg440His substitution
    Delphine Allorge
    EA2679, Faculté de Médecine Pôle Recherche, 59045 Lille, France
    Proteins 59:339-46. 2005
    ..Docking the structure of the FMN domain of human cytochrome P450 reductase to the CYP2D6 model suggests that Arg440 is a key member of a cluster of basic amino acid residues important for reductase binding...
  21. pmc Identification of a novel splice-site mutation in the CYP1A2 gene
    Delphine Allorge
    EA 2679, Faculté de Médecine Pôle Recherche, 1 place de Verdun, F 59045 Lille Cedex, France
    Br J Clin Pharmacol 56:341-4. 2003
    ....
  22. ncbi Evidence for a functional genetic polymorphism of the human retinoic acid-metabolizing enzyme CYP26A1, an enzyme that may be involved in spina bifida
    Emmanuel Rat
    Equipe d accueil EA2679, Faculte de Medecine, Lille Cedex, France
    Birth Defects Res A Clin Mol Teratol 76:491-8. 2006
    ..As RA is a critical regulator of gene expression during embryonic development, the imbalance between the synthesis and degradation of RA during embryogenesis could contribute to malformations and developmental defects...