William A Catterall
Levin M, Singh G, Zhang H, Uchida K, Kozel B, Stein P, et al
. K(ATP) channel gain-of-function leads to increased myocardial L-type Ca(2+) current and contractility in Cantu syndrome. Proc Natl Acad Sci U S A. 2016;113:6773-8 pubmed publisher
..2 at Ser1928, suggesting enhanced protein kinase activity as a potential link between increased KATP current and CS cardiac pathophysiology. ..
Gamal El Din T, Lenaeus M, Ramanadane K, Zheng N, Catterall W. Molecular dissection of multiphase inactivation of the bacterial sodium channel NaVAb. J Gen Physiol. 2018;: pubmed publisher
..These results have important implications for the sequence of conformational changes that lead to multiphase inactivation of NaVAb and other sodium channels. ..
Catterall W, Zheng N. Deciphering voltage-gated Na(+) and Ca(2+) channels by studying prokaryotic ancestors. Trends Biochem Sci. 2015;40:526-34 pubmed publisher
..New insights into their voltage-dependent activation and inactivation, ion conductance, and ion selectivity provide realistic structural models for the function of these complex membrane proteins at the atomic level. ..
Catterall W. Regulation of Cardiac Calcium Channels in the Fight-or-Flight Response. Curr Mol Pharmacol. 2015;8:12-21 pubmed
..2 channels serves as a signaling platform, mediating beat-to-beat physiological regulation of channel activity and up-regulation by Î²-adrenergic signaling in the fight-or-flight response. ..
Nanou E, Catterall W. Calcium Channels, Synaptic Plasticity, and Neuropsychiatric Disease. Neuron. 2018;98:466-481 pubmed publisher
..ThisÂ article reviews the molecular properties of calcium channels, considers their multiple roles in synaptic plasticity, and discusses their potential involvement in this wide range of neuropsychiatric diseases. ..
Catterall W, Swanson T. Structural Basis for Pharmacology of Voltage-Gated Sodium and Calcium Channels. Mol Pharmacol. 2015;88:141-50 pubmed publisher
Nanou E, Lee A, Catterall W. Control of Excitation/Inhibition Balance in a Hippocampal Circuit by Calcium Sensor Protein Regulation of Presynaptic Calcium Channels. J Neurosci. 2018;38:4430-4440 pubmed publisher
..Disruption of this regulation causes altered short-term plasticity and impaired balance of hippocampal excitatory to inhibitory circuits. ..
Jiang D, Gamal El Din T, Ing C, Lu P, Pomès R, Zheng N, et al
. Structural basis for gating pore current in periodic paralysis. Nature. 2018;557:590-594 pubmed publisher
..Our results reveal pathogenic mechanisms of periodic paralysis at the atomic level and suggest designs of drugs that may prevent ionic leak and provide symptomatic relief from hypokalaemic and normokalaemic periodic paralysis. ..
Yu H, Yuan C, Westenbroek R, Catterall W. The AKAP Cypher/Zasp contributes to β-adrenergic/PKA stimulation of cardiac CaV1.2 calcium channels. J Gen Physiol. 2018;150:883-889 pubmed publisher
..2 channels. Other AKAPs may work cooperatively with Cypher/Zasp to give the full magnitude of β-adrenergic regulation of CaV1.2 channels observed in vivo. ..