Using palliative care in progressive neuromuscular disease to maximize quality of lifeGregory T Carter
Department of Physical Medicine and Rehabilitation, University of California at Davis, 2315 Stockton Boulevard, Sacramento, CA 95817, USA Hospice and Palliative Care Services, Providence Health Services, 413 Lilly Road Northeast, Olympia, WA 98506 5166, USA Electronic address
Phys Med Rehabil Clin N Am 23:903-9. 2012
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- Disease burden in neuromuscular disease: the role of chronic pain
Gregory T Carter
Olympia Physical Medicine, 410 Providence Lane, Building 2, Olympia, WA 98506, USA
Phys Med Rehabil Clin N Am 23:719-29. 2012
..Better measurement tools for chronic pain, quality of life, and burden of disease are needed and could be used via NMD registries to address the knowledge gap in this area...
Psychoactive substances and the political ecology of mental distressSunil K Aggarwal
Department of Physical Medicine and Rehabilitation, New York University, Rusk Institute of Rehabilitation Medicine, 400 E 34th St, New York, NY 10016 USA
Harm Reduct J 9:4. 2012
..It closes with proposing a non-criminalizing public health approach for regulating human close contact with psychoactive substances using the example of cannabis use...
- Aging with muscular dystrophy: pathophysiology and clinical management
Gregory T Carter
Department of Rehabilitation Medicine, University of Washington School of Medicine, Box 356490, Seattle, WA 98195, USA
Phys Med Rehabil Clin N Am 21:429-50. 2010
..A comprehensive medical and rehabilitative approach to management of aging MD patients can often fulfill expectations and help them enjoy an enhanced quality of life...
- Cannabis in palliative medicine: improving care and reducing opioid-related morbidity
Gregory T Carter
Hospice Services, Providence Medical Group, Olympia, WA 98531, USA
Am J Hosp Palliat Care 28:297-303. 2011
..Using this foundation, an argument is made for reclassifying cannabis in the context of improving palliative care and reducing opioid-related morbidity...
- Cannabis and amyotrophic lateral sclerosis: hypothetical and practical applications, and a call for clinical trials
Gregory T Carter
Muscular Dystrophy Association Amyotrophic Lateral Sclerosis Center, University of Washington Medical Center, Seattle, WA, USA
Am J Hosp Palliat Care 27:347-56. 2010
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- Pain in persons with postpolio syndrome: frequency, intensity, and impact
Brenda L Stoelb
Department of Rehabilitation Medicine, University of Washington School of Medicine, Seattle, WA 98195 6490, USA
Arch Phys Med Rehabil 89:1933-40. 2008
..To describe the frequency, intensity, and impact of pain in persons with postpoliomyelitis syndrome (PPS)...
Characteristics of patients with chronic pain accessing treatment with medical cannabis in Washington StateSunil K Aggarwal
University of Washington, Seattle, Washington, USA
J Opioid Manag 5:257-86. 2009
..This study was conducted to better understand the characteristics of chronic pain patients seeking treatment with medicinal cannabis (MC)...
- Current pharmacological management of amyotrophic [corrected] lateral sclerosis and a role for rational polypharmacy
Michael D Weiss
University of Washington Medical Center, Seattle, WA 98195, USA
Expert Opin Pharmacother 5:735-46. 2004
..Based on the available data, it is our opinion that combination drug therapies should be considered for future clinical trials...
- Chronic pain in persons with myotonic dystrophy and facioscapulohumeral dystrophy
Mark P Jensen
Department of Rehabilitation Medicine, University of Washington School of Medicine, Seattle 98195 6490, USA
Arch Phys Med Rehabil 89:320-8. 2008
..To determine the nature and scope of pain in working-aged adults with myotonic muscular dystrophy (MMD) and facioscapulohumeral muscular dystrophy (FSHD)...
- Exercise in neuromuscular diseases
R Ted Abresch
Department of Rehabilitation Medicine, University of California, Davis, 4860 Y Street Suite, 3850, Sacramento, CA 95817, USA
Phys Med Rehabil Clin N Am 23:653-73. 2012
..In addition to traditional measures of exercise efficacy, outcome variables should include measures of functional status and health-related quality of life...
- Chronic pain in persons with neuromuscular disease
Mark P Jensen
Department of Rehabilitation Medicine, University of Washington School of Medicine, Box 356490, Seattle, WA 98195 6490, USA
Arch Phys Med Rehabil 86:1155-63. 2005
..To examine the nature and scope of pain in persons with neuromuscular disorder (NMD)...
- Drug therapy for amyotrophic lateral sclerosis: Where are we now?
Gregory T Carter
Muscular Dystrophy Association Amyotrophic Lateral Sclerosis Center, University of Washington School of Medicine, Seattle, WA 98195, USA
IDrugs 6:147-53. 2003
..We indicate current and future directions in research and clinical trials, and also argue that a logical next step for clinical trials in ALS should be combination drug treatment...
- Modafinil to treat fatigue in amyotrophic lateral sclerosis: an open label pilot study
Gregory T Carter
Department of Rehabilitation Medicine, University of Washington School of Medicine, Seattle, Washington, USA
Am J Hosp Palliat Care 22:55-9. 2005
..1 (SD 5.4), with p < 0.01. This pilot study suggests that modafinil is well-tolerated and may reduce symptoms of fatigue in ALS. Further blinded, controlled studies of modafinil in larger numbers of ALS patients are warranted...
- Axonal degeneration in the Trembler-j mouse demonstrated by stimulated single-fiber electromyography
Gregg D Meekins
Department of Neurology, University of Washington Medical Center, Seattle, Washington 98195, USA
Muscle Nerve 36:81-6. 2007
..This technique may be a valuable tool to study the affects of genetic or pharmaceutical interventions in murine models of peripheral neuropathy. Muscle Nerve, 2007...
- Medical marijuana: emerging applications for the management of neurologic disorders
Gregory T Carter
Department of Rehabilitation Medicine, University of Washington School of Medicine, 1959 NE Pacific Avenue, Box 356490, Seattle, WA 98195, USA
Phys Med Rehabil Clin N Am 15:943-54, ix. 2004
..This article reviews the current and emerging research on the physiologic mechanisms of endogenous and exogenous cannabinoids and their applications in the management of neurologic disease...
- Electromyographic studies in mdx and wild-type C57 mice
Jay J Han
Department of Rehabilitation Medicine, University of Washington School of Medicine, Seattle, USA
Muscle Nerve 33:208-14. 2006
..This is important as there are few objective measures of muscle function in murine models that do not require killing the animal...
- Chronic pain in persons with neuromuscular disease
Amy J Hoffman
Department of Rehabilitation Medicine, Box 356490, University of Washington School of Medicine, Seattle, WA 98195-6490, USA
Phys Med Rehabil Clin N Am 16:1099-112, xii. 2005
- Coping with chronic pain among younger, middle-aged, and older adults living with neurological injury and disease
Ivan Molton
University of Washington School of Medicine, USA
J Aging Health 20:972-96. 2008
..Discussion. These data suggest differences in the quantity and quality of pain coping among age groups...
- Pain in youths with neuromuscular disease
Joyce M Engel
Department of Rehabilitation Medicine, University of Washington School of Medicine, Seattle, Washington 98195, USA
Am J Hosp Palliat Care 26:405-12. 2009
..This study indicates that chronic pain is a significant problem in youths with NMD. These data strongly support making comprehensive pain assessment and management an integral part of the standard of care for youths with NMD...
- Medicinal cannabis: rational guidelines for dosing
Gregory T Carter
Department of Rehabilitation Medicine, University of Washington School of Medicine, Seattle, WA 98531, USA
IDrugs 7:464-70. 2004
..This paper will review the known chemistry and pharmacology of cannabis and, on that basis, discuss rational guidelines for dosing...
- Psychosocial factors and adjustment to pain in individuals with postpolio syndrome
Adam T Hirsh
Department of Rehabilitation Medicine, University of Washington School of Medicine, Seattle, Washington 98104, USA
Am J Phys Med Rehabil 89:213-24. 2010
..The purpose of the current study was to examine the associations among measures of psychosocial factors, pain, and adjustment in persons with postpoliomyelitis syndrome...
- Drug therapy in amyotrophic lateral sclerosis
B Jane Distad
Department of Neurology, University of Washington Medical Center, 1959 NE Pacific Street, Seattle, WA 98195, USA
Phys Med Rehabil Clin N Am 19:633-51, xi-xii. 2008
..The authors review the current understanding of the pathogenic mechanisms of ALS and approaches to treating the disease...
- The reliability and validity of a self-report version of the FIM instrument in persons with neuromuscular disease and chronic pain
Mark P Jensen
Department of Rehabilitation Medicine, University of Washington, Seattle, WA 98195, USA
Arch Phys Med Rehabil 86:116-22. 2005
..To evaluate the reliability and validity of a self-report version of the FIM instrument (FIM-SR)...
- The magnetic resonance imaging spectrum of facioscapulohumeral muscular dystrophy
Seth D Friedman
Department of Radiology, Seattle Children s Hospital, 4800 Sandpoint Way, Room R4488, Seattle, Washington 98105, USA
Muscle Nerve 45:500-6. 2012
..We used a one-step quantitative magnetic resonance imaging (MRI) method to evaluate muscle, edema, and fat in patients spanning the range of severity...
- Survey of cannabis use in patients with amyotrophic lateral sclerosis
Dagmar Amtmann
Department of Rehabilitation Medicine, University of Washington School of Medicine, Seattle, Washington, USA
Am J Hosp Palliat Care 21:95-104. 2004
..Cannabis was reported ineffective in reducing difficulties with speech and swallowing, and sexual dysfunction. The longest relief was reported for depression (approximately two to three hours)...
- Medicinal use of cannabis in the United States: historical perspectives, current trends, and future directions
Sunil K Aggarwal
Medical Scientist Training Program, University of Washington, Seattle, WA, USA
J Opioid Manag 5:153-68. 2009
..This article reviews the current and emerging research on the physiological mechanisms of cannabinoids and their applications in managing chronic pain, muscle spasticity, cachexia, and other debilitating problems...
- Modafinil reduces fatigue in Charcot-Marie-Tooth disease type 1A: a case series
Gregory T Carter
Department of Rehabilitation Medicine, University of Washington School of Medicine, Seattle, Washington, USA
Am J Hosp Palliat Care 23:412-6. 2006
..We report 4 patients with genetically confirmed Charcot-Marie-Tooth disease who had significant fatigue that was almost completely relieved by modafinil...
- The importance of assessing quality of life in patients with neuromuscular disorders
Gregory T Carter
Department of Rehabilitation Medicine, University of Washington School of Medicine, Seattle, Centralia, WA 98531, USA
Am J Hosp Palliat Care 23:493-7. 2006
- Assessment of pain and health-related quality of life in slowly progressive neuromuscular disease
Richard T Abresch
University of California, Davis, Department of Physical Medicine and Rehabilitation, USA
Am J Hosp Palliat Care 19:39-48. 2002
..In conclusion, with the exception of adult SMA, the frequency and severity of pain reported in slowly progressive NMDs was significant...
- Rehabilitation management of neuromuscular disease: the role of exercise training
R Ted Abresch
Department of Physical Medicine and Rehabilitation, University of California, Davis, Davis, CA, USA
J Clin Neuromuscul Dis 11:7-21. 2009
..This review focuses on the role of exercise in a few of the specific NMDs where most research has taken place and recommends future research directions...
- Using electromyography to assess function in humans and animal models of muscular dystrophy
Jay J Han
Department of Physical Medicine and Rehabilitation, University of California-Davis, 4860 Y Street, Suite 3850, Sacramento, CA 95817, USA
Phys Med Rehabil Clin N Am 16:981-97, x. 2005
- Myotonic dystrophy type 1 coexisting with myasthenia gravis and thymoma
Timothy Feyma
Department of Neurology, University of Washington Medical Center, 1959 NE Pacific Street, Seattle, WA 98195, USA
Muscle Nerve 38:916-20. 2008
..Therefore, abnormal CTG repeat expansions in the gene could lead to the development of thymoma and myasthenia gravis...
- Dosing medical marijuana: rational guidelines on trial in Washington State
Sunil K Aggarwal
University of Washington School of Medicine, Seattle, USA
MedGenMed 9:52. 2007
- New clinical end points in rehabilitation medicine: tools for measuring quality of life
Richard T Abresch
Department of Physical Medicine and Rehabilitation, University of California at Davis, Sacramento, CA 95616, USA
Am J Hosp Palliat Care 26:483-92. 2009
..The goals for this article are to show the value of performing HRQoL measurements and briefly describe methods used to assess quality of life (QoL)...
- Preface: the state of the science of all motor neuron diseases
Michael D Weiss
Department of Neurology, University of Washington Medical Center, 1959 NE Pacific Street, Room NN282A, Box 356115, Seattle, WA 98195, USA
Phys Med Rehabil Clin N Am 19:xix-xx. 2008
- Body composition and water compartment measurements in boys with Duchenne muscular dystrophy
Craig M McDonald
Department of Physical Medicine and Rehabilitation, University of California-Davis School of Medicine, Davis, California, USA
Am J Phys Med Rehabil 84:483-91. 2005
..Although MFBIA slightly underestimates lean tissue mass in boys with DMD, it has a potential role as an inexpensive and easy to use measurement tool to measure changes in muscle mass in the clinical setting...
- Iatrogenic axillary neuropathy after intramuscular injection of the deltoid muscle
Loren T Davidson
Department of Physical Medicine and Rehabilitation, University of California Davis Medical Center, 4860 Y Street, Sacramento, CA 95817, USA
Am J Phys Med Rehabil 86:507-11. 2007
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- Electrodiagnostic evaluation of hereditary motor and sensory neuropathies
Gregory T Carter
Department of Rehabilitation Medicine, University of Washington School of Medicine, 1959 Northeast Pacific Avenue, Seattle, WA 98195, USA
Phys Med Rehabil Clin N Am 14:347-63, ix-x. 2003
..Nevertheless, there are exceptions. This article reviews the available literature and describes the electrodiagnostic approach to HMSN, detailing potential sources of error that can lead to misinterpretation of data...
- The amyotrophic lateral sclerosis center: a model of multidisciplinary management
Angeli S Mayadev
Department of Physical Medicine and Rehabilitation, University of Washington Medical Center, 1959 NE Pacific Street, Seattle, WA 98195, USA
Phys Med Rehabil Clin N Am 19:619-31, xi. 2008
..This article provides a summary of the current research into the rehabilitation of ALS, including the role of exercise, spasticity management, mood disorders, pain, and palliative care...
- Neuro-inflammation as a therapeutic target in amyotrophic lateral sclerosis
Patrick Weydt
Department of Neurology, University of Washington School of Medicine, 1959 Northeast Pacific Avenue, Seattle, WA 98195, USA
Curr Opin Investig Drugs 3:1720-4. 2002
..This article reviews the current research in this area and discusses theoretical and clinical ramifications of these recent findings...
- Amyotrophic lateral sclerosis: practical aspects of care
Lisa S Krivickas
Department of Physical Medicine and Rehabilitation, Harvard Medical School, Spaulding Rehabilitation Hospital, Boston, Massachusetts, USA
J Spinal Cord Med 25:274-6. 2002
- Skeletal muscle edema in muscular dystrophy: clinical and diagnostic implications
Sandra L Poliachik
Department of Radiology, Seattle Children s Hospital, Seattle, WA 98105, USA
Phys Med Rehabil Clin N Am 23:107-22, xi. 2012
..Lastly, refining current techniques and adapting other MRI capabilities may enhance detection and assessment of edema for better evaluation of disease progression and treatment outcomes...
- Medical marijuana: politics trumps science at the FDA
Gregory T Carter
University of Washington School of Medicine, Seattle, Washington, USA
MedGenMed 8:46. 2006
- Cannabis: old medicine with new promise for neurological disorders
Gregory T Carter
Department of Rehabilitation Medicine, University of Washington School of Medicine, Seattle 98531, USA
Curr Opin Investig Drugs 3:437-40. 2002
..This article reviews the emerging research on the physiological mechanisms of endogenous and exogenous cannabinoids in the context of neurological disease...
- Adaptations to exercise training and contraction-induced muscle injury in animal models of muscular dystrophy
Gregory T Carter
Department of Rehabilitation Medicine, School of Medicine, University of Washington, Seattle, Washington, USA
Am J Phys Med Rehabil 81:S151-61. 2002
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- Double trouble in hereditary neuropathy: concomitant mutations in the PMP-22 gene and another gene produce novel phenotypes
Julie A Hodapp
Department of Rehabilitation Medicine, School of Medicine, University of Washington, Seattle, USA
Arch Neurol 63:112-7. 2006
..CONCLUSIONS: Individuals having 2 separate mutations in neuromuscular disease-related genes may develop unusually severe phenotypes. Neurologists should be alert to this possibility...
