V Carreno

Summary

Publications

  1. ncbi request reprint Present treatment expectations and risks of chronic hepatitis C
    V Carreno
    Fundación para el Estudio de las Hepatitis Virales and Instituto de Hepatología, Hospital Pardo de Aravaca, Madrid, Spain
    Clin Microbiol Infect 8:74-9. 2002
  2. ncbi request reprint Detection of hepatitis C virus (HCV) RNA in the liver of healthy, anti-HCV antibody-positive, serum HCV RNA-negative patients with normal alanine aminotransferase levels
    Vicente Carreno
    Fundacion para el Estudio de las Hepatitis Virales, Madrid, Spain
    J Infect Dis 194:53-60. 2006
  3. doi request reprint Presence of HCV-RNA after ultracentrifugation of serum samples during the follow-up of chronic hepatitis C patients with a sustained virological response may predict reactivation of hepatitis C virus infection
    I Castillo
    Fundacion para el Estudio de las Hepatitis Virales, Madrid, Spain
    Aliment Pharmacol Ther 30:477-86. 2009
  4. ncbi request reprint Occult hepatitis C virus infection: a new form of hepatitis C
    Vicente Carreno
    Fundacion para el Estudio de las Hepatitis Virales, Guzman el Bueno, 72, Madrid 28015, Spain
    World J Gastroenterol 12:6922-5. 2006
  5. doi request reprint [Occult hepatitis C virus infection]
    Vicente Carreño García
    Fundacion para el Estudio de las Hepatitis Virales, Madrid, Espana
    Enferm Infecc Microbiol Clin 29:14-9. 2011
  6. doi request reprint Occult hepatitis B virus and hepatitis C virus infections
    Vicente Carreno
    Fundacion para el Estudio de las Hepatitis Virales, Madrid, Spain
    Rev Med Virol 18:139-57. 2008
  7. ncbi request reprint Extended follow-up of anti-HBe-positive patients with chronic hepatitis B retreated with ribavirin and interferon-alpha
    V Carreno
    Institute of Hepatology, Hospital Pardo de Aravaca and Fundación para el Estudio de las Hepatitis Virales, C Guzmán el Bueno, 72, 28015 Madrid, Spain
    Antiviral Res 52:147-52. 2001
  8. ncbi request reprint Effect of anti-viral therapy for occult hepatitis C virus infection
    M Pardo
    Fundacion para el Estudio de las Hepatitis Virales, Madrid, Spain
    Aliment Pharmacol Ther 23:1153-9. 2006
  9. ncbi request reprint The role of genomic and antigenomic HCV-RNA strands as predictive factors of response to pegylated interferon plus ribavirin therapy
    J M Lopez-Alcorocho
    Fundacion para el Estudio de las Hepatitis Virales, Madrid, Spain
    Aliment Pharmacol Ther 25:1193-201. 2007
  10. pmc Hepatitis C virus (HCV) and hepatitis B virus (HBV) can coinfect the same hepatocyte in the liver of patients with chronic HCV and occult HBV infection
    E Rodriguez-Inigo
    Fundacion para el Estudio de las Hepatitis Virales, C Guzmán el Bueno, 72, 28015 Madrid, Spain
    J Virol 79:15578-81. 2005

Collaborators

  • Guillermina Barril
  • R Selgas
  • J Martin
  • M Fernandez
  • U Hedner
  • S W Schalm
  • J Fevery
  • S Zeuzem
  • U Hopf
  • M Peters
  • Mario Espinosa
  • O Weiland
  • Matti Sallberg
  • Javier Bartolome
  • Inmaculada Castillo
  • Elena Rodríguez-Iñigo
  • Margarita Pardo
  • Juan A Quiroga
  • E Rodriguez-Inigo
  • J Bartolome
  • I Castillo
  • J M Lopez-Alcorocho
  • M Pardo
  • Juan Manuel López-Alcorocho
  • Nuria Ortiz-Movilla
  • N Ortiz-Movilla
  • J A Quiroga
  • Juan Antonio Quiroga
  • Susana de Lucas
  • Miguel A Rico
  • Silvia Llorente
  • Vicente Carreño García
  • Pablo Lazaro
  • Sonia Vidal
  • F Manzarbeitia
  • Luisa Fernanda Mariscal
  • Javier Graus
  • Arturo Pérez-Mota
  • Susana de Lucas Sd
  • Cristina Navacerrada
  • Susana Castañón
  • Dolores Subira
  • Manuel Lecona
  • Isabel Longo
  • Luisa F Mariscal
  • M Cabrerizo
  • M E García-Jiménez
  • H Oliva
  • M Casqueiro
  • Javier Bartolomé Nebreda
  • Inmaculada Castillo Aguilar
  • Juan Antonio Quiroga Estévez
  • Jose Antonio Rodriguez-Montes
  • Luis García-Sancho
  • Isabel Pascual-Miguelañez
  • Pedro Quadros
  • Alejo Erice
  • M E Castellanos
  • Ricardo Palacios
  • A Perez-Mota
  • Juan José Arrieta
  • C Platero
  • Begoña Bartolomé Villar
  • S de Lucas
  • Felix Manzarbeitia
  • Esther Jiménez
  • Secundino Cigarran
  • Sara Ruiz
  • Clara Salas
  • Jose A Jimenez-Heffernan
  • María José Amaro
  • Luisa Mariscal
  • Esteban Garcia
  • Mercedes Pico
  • Geert Leroux-Roels
  • Javier Olalquiaga
  • Patricia García-Morrás
  • J F Tomas
  • M L Gutierrez
  • M L Manzano
  • J J Arrieta
  • A Suarez
  • J A Traver
  • P Sanz
  • C Arocena
  • M Herrero

Detail Information

Publications53

  1. ncbi request reprint Present treatment expectations and risks of chronic hepatitis C
    V Carreno
    Fundación para el Estudio de las Hepatitis Virales and Instituto de Hepatología, Hospital Pardo de Aravaca, Madrid, Spain
    Clin Microbiol Infect 8:74-9. 2002
    ..Nevertheless, the sustained response rate mainly depends on HCV RNA load and HCV genotype. Presumably, in future, new strategies based on gene therapy will play an important role in the treatment of chronic hepatitis C...
  2. ncbi request reprint Detection of hepatitis C virus (HCV) RNA in the liver of healthy, anti-HCV antibody-positive, serum HCV RNA-negative patients with normal alanine aminotransferase levels
    Vicente Carreno
    Fundacion para el Estudio de las Hepatitis Virales, Madrid, Spain
    J Infect Dis 194:53-60. 2006
    ..It is unknown whether hepatitis C virus (HCV) is present in the liver of anti-HCV antibody-positive patients with persistently normal alanine aminotransferase (ALT) levels and undetectable serum HCV RNA levels...
  3. doi request reprint Presence of HCV-RNA after ultracentrifugation of serum samples during the follow-up of chronic hepatitis C patients with a sustained virological response may predict reactivation of hepatitis C virus infection
    I Castillo
    Fundacion para el Estudio de las Hepatitis Virales, Madrid, Spain
    Aliment Pharmacol Ther 30:477-86. 2009
    ..Concentration of viral particles by ultracentrifugation of serum prior to PCR allows detection of hepatitis C virus (HCV) RNA in patients with undetectable viral RNA by conventional PCR assays...
  4. ncbi request reprint Occult hepatitis C virus infection: a new form of hepatitis C
    Vicente Carreno
    Fundacion para el Estudio de las Hepatitis Virales, Guzman el Bueno, 72, Madrid 28015, Spain
    World J Gastroenterol 12:6922-5. 2006
    ..This review describes recent studies of occult HCV infection in both kinds of patients...
  5. doi request reprint [Occult hepatitis C virus infection]
    Vicente Carreño García
    Fundacion para el Estudio de las Hepatitis Virales, Madrid, Espana
    Enferm Infecc Microbiol Clin 29:14-9. 2011
    ..This occult HCV infection can also be found in subjects without clinical or biochemical evidence of liver disease...
  6. doi request reprint Occult hepatitis B virus and hepatitis C virus infections
    Vicente Carreno
    Fundacion para el Estudio de las Hepatitis Virales, Madrid, Spain
    Rev Med Virol 18:139-57. 2008
    ..The clinical relevance of occult HCV infections is still under investigation...
  7. ncbi request reprint Extended follow-up of anti-HBe-positive patients with chronic hepatitis B retreated with ribavirin and interferon-alpha
    V Carreno
    Institute of Hepatology, Hospital Pardo de Aravaca and Fundación para el Estudio de las Hepatitis Virales, C Guzmán el Bueno, 72, 28015 Madrid, Spain
    Antiviral Res 52:147-52. 2001
    ....
  8. ncbi request reprint Effect of anti-viral therapy for occult hepatitis C virus infection
    M Pardo
    Fundacion para el Estudio de las Hepatitis Virales, Madrid, Spain
    Aliment Pharmacol Ther 23:1153-9. 2006
    ..Occult hepatitis C virus infection is defined by the presence of hepatitis C virus-RNA in liver but with undetectable anti-hepatitis C virus and serum viral RNA...
  9. ncbi request reprint The role of genomic and antigenomic HCV-RNA strands as predictive factors of response to pegylated interferon plus ribavirin therapy
    J M Lopez-Alcorocho
    Fundacion para el Estudio de las Hepatitis Virales, Madrid, Spain
    Aliment Pharmacol Ther 25:1193-201. 2007
    ..Hepatitis C virus replicates by the synthesis of an antigenomic HCV-RNA. As the end point of anti-viral therapy is to decrease viral replication, the amount of antigenomic HCV-RNA could influence the response...
  10. pmc Hepatitis C virus (HCV) and hepatitis B virus (HBV) can coinfect the same hepatocyte in the liver of patients with chronic HCV and occult HBV infection
    E Rodriguez-Inigo
    Fundacion para el Estudio de las Hepatitis Virales, C Guzmán el Bueno, 72, 28015 Madrid, Spain
    J Virol 79:15578-81. 2005
    ..This finding supports the hypothesis of inhibition of HBV replication by HCV. Furthermore, HCV RNA levels were lower in coinfected cells than in cells infected only with HCV, suggesting that HBV may also inhibit HCV replication...
  11. ncbi request reprint Retreatment of chronic hepatitis B e antigen-positive patients with recombinant interferon alfa-2a. The European Concerted Action on Viral Hepatitis (EUROHEP)
    V Carreno
    Department of Hepatology, Fundacion Jimenez Diaz, Madrid, Spain
    Hepatology 30:277-82. 1999
    ..In summary, viremic patients with chronic HBeAg-positive hepatitis may experience disease remission following retreatment with IFN-alpha. Thus, retreatment with IFN-alpha may be considered a therapeutic option...
  12. pmc Hepatitis C virus replicates in peripheral blood mononuclear cells of patients with occult hepatitis C virus infection
    I Castillo
    Fundacion para el Estudio de las Hepatitis Virales, Guzman el Bueno, 72, 28015 Madrid, Spain
    Gut 54:682-5. 2005
    ..Up to 70% of these patients also have HCV-RNA in peripheral blood mononuclear cells (PBMC) but it is not known if HCV is replicating in these cells...
  13. ncbi request reprint Prevalence of hepatitis B, hepatitis C, GB virus C/hepatitis G and TT viruses in predialysis and hemodialysis patients
    J M Lopez-Alcorocho
    Department of Hepatology, Fundación Jiménez Díaz and Fundación para el Estudio de las Hepatitis Virales, Madrid, Spain
    J Med Virol 63:103-7. 2001
    ..In conclusion, the prevalence of the viruses studied in predialysis may influence their prevalence in dialysis units...
  14. pmc Detection of TT virus DNA in liver biopsies by in situ hybridization
    E Rodriguez-Inigo
    Departments of Hepatology and Pathology, Fundacion Jimenez Diaz, Madrid, Spain
    Am J Pathol 156:1227-34. 2000
    ..1% to 30% and correlated with the TTV-DNA titers in liver (r = 0.54; P = 0.037). In conclusion, our results show that TTV is able to infect liver cells although they do not support a role for TTV in causing liver disease...
  15. ncbi request reprint Randomized controlled trial of recombinant human granulocyte-macrophage colony-stimulating factor for the treatment of chronic hepatitis c
    V Carreno
    Department of Hepatology, Fundacion Jimenez Diaz, Madrid, Spain
    Cytokine 12:165-70. 2000
    ..In summary, daily s.c. GM-CSF administration is safe and shows effects against HCV; the GM-CSF/IFNalpha2b combination has an additional-but transient-antiviral activity in chronic hepatitis C...
  16. ncbi request reprint Occult hepatitis C virus infection in patients in whom the etiology of persistently abnormal results of liver-function tests is unknown
    Inmaculada Castillo
    Fundacion para el Estudio de las Hepatitis Virales, Clinica Puerta de Hierro, Madrid, Spain
    J Infect Dis 189:7-14. 2004
    ..We analyzed the presence of hepatitis C virus (HCV) RNA in liver-biopsy specimens from 100 patients who were negative for anti-HCV antibodies and for serum HCV RNA and who had ALF-EU...
  17. ncbi request reprint Comparative study on the clinical and virological characteristics among patients with single occult hepatitis B virus (HBV), single occult hepatitis C virus (HCV) and occult HBV and HCV dual infection
    Inmaculada Castillo
    Fundacion para el Estudio de las Hepatitis Virales, Madrid, Spain
    J Med Virol 79:236-41. 2007
    ..Moreover, in occult dual infection there is no a reciprocal inhibition of the viral genomes...
  18. ncbi request reprint Prevalence of TT virus in serum and peripheral mononuclear cells from a CAPD population
    G Barril
    Nephrology Service, Hospital Universitario La Princesa, Madrid, Spain
    Perit Dial Int 20:65-8. 2000
    ....
  19. ncbi request reprint Expression of factor VII in the liver of patients with liver disease: correlations with the disease severity and impairment in the hemostasis
    E Rodriguez-Inigo
    Instituto de Hepatologia, Hospital Pardo de Aravaca, Madrid, Spain
    Blood Coagul Fibrinolysis 12:193-9. 2001
    ..The percentage of hepatocytes expressing FVII decreases as the severity of liver damage increases...
  20. ncbi request reprint Comparative study between occult hepatitis C virus infection and chronic hepatitis C
    M Pardo
    Fundacion para el Estudio de las Hepatitis Virales, Madrid, Spain
    J Viral Hepat 14:36-40. 2007
    ..001) in chronic HCV (10.1%) than in occult HCV infection (5.3%). This occult HCV infection is a milder disease than chronic HCV, and this could be related to the significantly lower number of infected hepatocytes observed in occult HCV...
  21. ncbi request reprint TT virus detection in oral lichen planus lesions
    E Rodriguez-Inigo
    Fundacion para el Estudio de las Hepatitis Virales, C Guzmán el Bueno, 72, 28015 Madrid, Spain
    J Med Virol 64:183-9. 2001
    ..In conclusion, TT virus infects oral epithelial cells but the results do not support a role for TT virus in causing oral lichen planus...
  22. ncbi request reprint Hepatitis B infection of the liver in chronic hepatitis C without detectable hepatitis B virus DNA in serum
    Luisa Fernanda Mariscal
    Fundacion para el Estudio de las Hepatitis Virales, Madrid, Spain
    J Med Virol 73:177-86. 2004
    ..53 +/- 0.66). In conclusion, a significant proportion of patients with chronic HCV infection have HBV-DNA in the liver in the absence of viral DNA in serum. The impact of this finding on liver histology deserves further research...
  23. ncbi request reprint Distribution of hepatitis B virus in the liver of chronic hepatitis C patients with occult hepatitis B virus infection
    Elena Rodríguez-Iñigo
    Fundación para el Estudio de la Hepatitis Virales, Madrid, Spain
    J Med Virol 70:571-80. 2003
    ..In conclusion, patients with occult HBV infection have a low number of HBV-infected hepatocytes and this fact could explain the lack of HBsAg detection and low viremia levels found in these cases...
  24. ncbi request reprint Pegylated interferon-alpha2a kinetics during experimental haemodialysis: impact of permeability and pore size of dialysers
    G Barril
    Department of Nephrology, Hospital U de La Princesa, Madrid, Spain
    Aliment Pharmacol Ther 20:37-44. 2004
    ..Pegylated interferon-alpha (PEG-IFN-alpha), a middle-size protein drug active against viral hepatitis, allows convenient once-weekly dosing due to prolonged plasma half-life...
  25. pmc Ultracentrifugation of serum samples allows detection of hepatitis C virus RNA in patients with occult hepatitis C
    Javier Bartolome
    Fundación Estudio Hepatitis Virales, Madrid, Spain
    J Virol 81:7710-5. 2007
    ..In conclusion, HCV RNA can be detected in the sera of patients with occult HCV infection after circulating viral particles are concentrated by ultracentrifugation...
  26. ncbi request reprint Virus-specific T-cell responses associated with hepatitis C virus (HCV) persistence in the liver after apparent recovery from HCV infection
    Juan A Quiroga
    Fundacion para el Estudio de las Hepatitis Virales, Madrid, Spain
    J Med Virol 78:1190-7. 2006
    ....
  27. ncbi request reprint In vitro infection of human peripheral blood mononuclear cells by a defective hepatitis B virus with a deletion in the PreS1 region of the viral genome
    M Cabrerizo
    Fundación para el Estudio de las Hepatitis Virales and Instituto de Hepatología, Hospital Pardo de Aravaca, Madrid, Spain
    J Viral Hepat 9:265-71. 2002
    ..In conclusion, this HBV deletion mutant can infect, replicate and release viral particles in in vitro infected PBMC...
  28. ncbi request reprint Ribozymes as antiviral agents
    J Bartolome
    Viral Hepatitis Research Foundation, Madrid, Spain
    Minerva Med 95:11-24. 2004
    ....
  29. ncbi request reprint Hepatitis C virus replicates in the liver of patients who have a sustained response to antiviral treatment
    Inmaculada Castillo
    Foundation for the Study of Viral Hepatitis, Madrid, 28015, Spain
    Clin Infect Dis 43:1277-83. 2006
    ..4+/-32.8 months after treatment...
  30. ncbi request reprint Hepatitis C virus replicates in sweat glands and is released into sweat in patients with chronic hepatitis C
    Nuria Ortiz-Movilla
    Institute of Hepatology, Hospital Pardo de Aravaca and Fundación para el Estudio de las Hepatitis Virales, Madrid, Spain
    J Med Virol 68:529-36. 2002
    ..No HCV RNA or HCV core protein was detected in the skin biopsies from the 10 anti-HCV negative patients. In conclusion, HCV replicates in eccrine sweat glands cells and keratinocytes in healthy skin and is released into the sweat...
  31. doi request reprint Hepatitis C virus infection in the family setting of patients with occult hepatitis C
    Inmaculada Castillo
    Fundación para el Estudio de Hepatitis Virales, Madrid, Spain
    J Med Virol 81:1198-203. 2009
    ..This stresses the need to adopt strategies to prevent the transmission of HCV in the family setting of patients with occult HCV infection...
  32. pmc Percentage of hepatitis C virus-infected hepatocytes is a better predictor of response than serum viremia levels
    Elena Rodríguez-Iñigo
    Fundacion para el Estudio de las Hepatitis Virales, C Guzmán el Bueno 72, 28015 Madrid, Spain
    J Mol Diagn 7:535-43. 2005
    ....
  33. pmc Occult hepatitis C virus infection among hemodialysis patients
    Guillermina Barril
    Department of Nephrology, Hospital de Princesa, Madrid, Spain
    J Am Soc Nephrol 19:2288-92. 2008
    ..The clinical significance of occult HCV infection in these patients requires further study...
  34. ncbi request reprint TT virus replicates in stimulated but not in nonstimulated peripheral blood mononuclear cells
    Luisa F Mariscal
    Institute of Hepatology, Hospital Pardo de Aravaca and Fundación para el Estudio de las Hepatitis Virales, Madrid, Spain
    Virology 301:121-9. 2002
    ..These results demonstrate that TTV replicates in PBMC only when stimulated...
  35. doi request reprint Diagnosis of occult hepatitis C without the need for a liver biopsy
    Inmaculada Castillo
    Foundation for the Study of Viral Hepatitis, 28015 Madrid, Spain
    J Med Virol 82:1554-9. 2010
    ..In conclusion, testing for all these markers allows diagnosis of occult HCV without the need for a liver biopsy and these assays may help to elucidate the clinical significance of occult HCV infection...
  36. doi request reprint Detection of hepatitis C virus in thyroid tissue from patients with chronic HCV infection
    Javier Bartolome
    Fundacion para el Estudio de las Hepatitis Virales, Madrid, Spain
    J Med Virol 80:1588-94. 2008
    ..In conclusion, the data obtained indicate that HCV may infect cells of the thyroid in immune competent patients with chronic HCV infection. The pathogenic implications of this finding merit further research...
  37. ncbi request reprint Association of HLA-DR genes with mild idiopathic adulthood biliary ductopenia
    M E García-Jiménez
    Institute of Hepatology, Hospital Pardo de Aravaca, Madrid, Spain
    Am J Gastroenterol 96:1178-82. 2001
    ..Although the underlying cause of MIAD is unknown, the host factors may contribute to the patient's susceptibility to the disease. The aim of this work was to investigate the immunogenetics in the pathogenesis of MIAD...
  38. ncbi request reprint Impaired interferon induction of human MxA protein in chronic hepatitis B virus infection
    M Fernandez
    Department of Hepatology, Fundacion Jimenez Diaz, Madrid, Spain
    J Med Virol 51:332-7. 1997
    ..These results indicate that chronic infection by hepatitis B virus may impair activation of the immune cells and their capacity to respond to type 1 interferons...
  39. ncbi request reprint Detection of hepatitis C virus RNA and core protein in keratinocytes from patients with cutaneous lichen planus and chronic hepatitis C
    Pablo Lazaro
    Department of Dermatology, Hospital General Universitario Gregorio Maranon, Madrid, Spain
    J Invest Dermatol 119:798-803. 2002
    ..8 +/- 6.9% and 14.3 +/- 3.8%, mean +/- SD). In conclusion, we have demonstrated that hepatitis C virus infects keratinocytes from patients with lichen planus and hepatitis C virus infection...
  40. pmc Cellular immune responses associated with occult hepatitis C virus infection of the liver
    Juan A Quiroga
    Fundacion para el Estudio de las Hepatitis Virales, Guzman el Bueno, 72, 28015 Madrid, Spain
    J Virol 80:10972-9. 2006
    ..These findings demonstrate that HCV-specific cellular immune responses are markers not only of previous exposure to and recovery from HCV but also of ongoing occult HCV infection...
  41. ncbi request reprint A phase I/II study of recombinant human interleukin-12 in patients with chronic hepatitis B
    V Carreno
    Fundacion Jimenez Diaz, Madrid, Spain
    J Hepatol 32:317-24. 2000
    ..03 microg/kg b.w., n=15; 0.25 microg/kg b.w., n=15; 0.50 microg/kg b.w., n=16) of recombinant human (rHu) IL-12 given s.c. once a week for 12 consecutive weeks...
  42. ncbi request reprint Virus-specific effector CD4+ T-cell responses in hemodialysis patients with hepatitis C virus infection
    Miguel A Rico
    Fundacion para el Estudio de las Hepatitis Virales, Madrid, Spain
    J Med Virol 72:66-74. 2004
    ..In conclusion, hemodialysis patients show limited HCV-specific effector CD4(+) Th1-cell responses which nonetheless seem unrelated to the anti-HCV status and are not more impaired due to the ongoing hemodialysis...
  43. ncbi request reprint Features of the CD4+ T-cell response in liver and peripheral blood of hepatitis C virus-infected patients with persistently normal and abnormal alanine aminotransferase levels
    Miguel A Rico
    Institute of Hepatology, Hospital Pardo de Aravaca, Madrid, Spain
    J Hepatol 36:408-16. 2002
    ..The liver is the primary site of hepatitis C virus (HCV) replication; intrahepatic T-cell responses may influence liver disease severity...
  44. pmc Combined hepatitis C virus (HCV) antigen-antibody detection assay does not improve diagnosis for seronegative individuals with occult HCV infection
    Juan A Quiroga
    Fundacion para el Estudio de las Hepatitis Virales, Guzmán el Bueno 72, 28015 Madrid, Spain
    J Clin Microbiol 44:4559-60. 2006
    ..Despite increased sensitivity the combined assay does not improve serodiagnosis of occult HCV infection...
  45. ncbi request reprint Hepatitis C virus does not infect muscle, the intervertebral disk, or the meniscus in patients with chronic hepatitis C
    Javier Bartolome
    Fundacion para el Estudio de las Hepatitis Virales, Madrid, Spain
    J Med Virol 79:1818-20. 2007
    ..In conclusion, the results do not support a direct role of HCV in musculoskeletal disorders associated with chronic hepatitis C...
  46. pmc Serum immunoglobulin G antibodies to the GOR autoepitope are present in patients with occult hepatitis C virus (HCV) infection despite lack of HCV-specific antibodies
    Juan A Quiroga
    Fundacion para el Estudio de las Hepatitis Virales, Guzman el Bueno, 72, 28015 Madrid, Spain
    Clin Vaccine Immunol 14:1302-6. 2007
    ..Testing for anti-GOR IgG in patients in whom HCV RNA is not detected in their sera may help with the identification of a subset of patients with occult HCV infection without the need to perform a liver biopsy...
  47. ncbi request reprint Detection of human immunodeficiency virus type 1 RNA by in situ hybridization in oral mucosa epithelial cells from anti-HIV-1 positive patients
    Elena Rodríguez-Iñigo
    Fundacióon para el estudio de las Hepatitis Virales, Madrid, Spain
    J Med Virol 77:17-22. 2005
    ....
  48. ncbi request reprint Current therapy of chronic hepatitis B
    Margarita Pardo
    Fundacion para el Estudio de las Hepatitis Virales, Madrid, Spain
    Arch Med Res 38:661-77. 2007
  49. doi request reprint Identification of serologically silent occult hepatitis C virus infection by detecting immunoglobulin G antibody to a dominant HCV core peptide epitope
    Juan A Quiroga
    Fundacion para el Estudio de las Hepatitis Virales, Guzman el Bueno, 72 28015 Madrid, Spain
    J Hepatol 50:256-63. 2009
    ..Occult HCV infection has been described among anti-HCV-HCV RNA-negative individuals with abnormal transaminase values in whom HCV RNA is detected in liver...
  50. doi request reprint Effect of hemodialysis schedules and membranes on hepatocyte growth factor and hepatitis C virus RNA levels
    Guillermina Barril
    Department of Nephrology, Hospital Universitario de la Princesa, Madrid, Spain
    J Med Virol 82:763-7. 2010
    ..These results suggest that changes in HCV RNA and HGF levels during hemodialysis are not influenced by the schedule or type of membrane used...
  51. ncbi request reprint Hepatitis C virus core protein transactivates the inducible nitric oxide synthase promoter via NF-kappaB activation
    Susana de Lucas
    Fundacion para el Estudio de las Hepatitis Virales, C Guzman el Bueno no 72, 28015 Madrid, Spain
    Antiviral Res 60:117-24. 2003
    ..The expression of the NF-kappaB inhibitor IKB reverts the effect of the HCV core protein on the iNOS promoter. In conclusion, HCV core protein transactivates iNOS gene promoter through NF-kappaB activation...
  52. ncbi request reprint Hepatitis B virus downregulates the human interferon-inducible MxA promoter through direct interaction of precore/core proteins
    Mario Fernandez
    Fundacion para el Estudio de las Hepatitis Virales, C Guzmán el Bueno 72, 28015 Madrid, Spain
    J Gen Virol 84:2073-82. 2003
    ..These results demonstrate a mechanism that HBV probably uses to downregulate an element of the IFN-induced host antiviral responses, which accounts for the impairment observed in HBV-infected patients...
  53. ncbi request reprint Nitric oxide and TGF-beta1 inhibit HNF-4alpha function in HEPG2 cells
    Susana de Lucas Sd
    Fundacion para el Estudio de las Hepatitis Virales, Madrid, Spain
    Biochem Biophys Res Commun 321:688-94. 2004
    ..TGF-beta1 and nitric oxide inhibit HNF-4alpha activity. These findings may explain the loss of liver functions that occurs during fibrosis progression...