Dirce Maria Carraro

Summary

Publications

  1. pmc Germline DNA copy number variation in familial and early-onset breast cancer
    Ana Cv Krepischi
    National Institute of Science and Technology in Oncogenomics, AC Camargo Hospital, Rua Taguá 440, 01508 010, Sao Paulo, Brazil
    Breast Cancer Res 14:R24. 2012
  2. pmc A novel SYBR-based duplex qPCR for the detection of gene dosage: detection of an APC large deletion in a familial adenomatous polyposis patient with an unusual phenotype
    Giovana Tardin Torrezan
    CIPE International Center of Research and Training A, C, Camargo Hospital, Rua Taguá, Sao Paulo, Brazil
    BMC Med Genet 13:55. 2012
  3. pmc Breakpoint characterization of a novel large intragenic deletion of MUTYH detected in a MAP patient: case report
    Giovana T Torrezan
    International Center of Research and Training CIPE, A, C, Camargo Hospital, Sao Paulo, SP, Brazil
    BMC Med Genet 12:128. 2011
  4. pmc Poly (A)+ transcriptome assessment of ERBB2-induced alterations in breast cell lines
    Dirce Maria Carraro
    Centro Internacional de Ensino e Pesquisa, Hospital AC Camargo, Sao Paulo, Sao Paulo, Brazil
    PLoS ONE 6:e21022. 2011
  5. pmc Influence of the interaction between nodal fibroblast and breast cancer cells on gene expression
    Rosângela Portilho Costa Santos
    Departamento de Radiologia e Oncologia, LIM24, Faculdade de Medicina, Universidade de Sao Paulo, Avenida Dr Arnaldo, 455, 4º andar, sala 4124, CEP 01246 903 Sao Paulo, SP, Brazil
    Tumour Biol 32:145-57. 2011
  6. doi Lymphovascular invasion and histologic grade are associated with specific genomic profiles in invasive carcinomas of the breast
    Felipe Fidalgo
    International Research Center, AC Camargo Cancer Center, Sao Paulo, Brazil
    Tumour Biol 36:1835-48. 2015
  7. doi Upregulated genes at 2q24 gains as candidate oncogenes in hepatoblastomas
    Tatiane Cristina Rodrigues
    Department of Genetics and Evolutionary Biology, Institute of Biosciences, University of Sao Paulo, Sao Paulo, Brazil
    Future Oncol 10:2449-57. 2014
  8. pmc Comprehensive analysis of BRCA1, BRCA2 and TP53 germline mutation and tumor characterization: a portrait of early-onset breast cancer in Brazil
    Dirce Maria Carraro
    Laboratory of Genomics and Molecular Biology, A C Camargo Hospital, Sao Paulo, Brazil
    PLoS ONE 8:e57581. 2013
  9. pmc MicroRNAs discriminate familial from sporadic non-BRCA1/2 breast carcinoma arising in patients ≤35 years
    Elen Pereira Bastos
    Oncology and Radiology Department, Laboratory of Medical Investigation 24 LIM 24, University of Sao Paulo, Medical School, Sao Paulo, Brazil
    PLoS ONE 9:e101656. 2014
  10. doi Germline CDKN2A mutations in Brazilian patients of hereditary cutaneous melanoma
    Alexandre Leon Ribeiro de Ávila
    Department of Skin Câncer, AC Camargo Cancer Center, Sao Paulo, Brazil
    Fam Cancer 13:645-9. 2014

Collaborators

  • Pedro A F Galante
  • Helena Brentani
  • Elisa Napolitano Ferreira
  • Israel Gomy
  • Samuel Aguiar
  • Ana Cristina Victorino Krepischi
  • Felipe Fidalgo
  • Carla Rosenberg
  • Benedito Mauro Rossi
  • Maria Mitzi Brentani
  • Fernando Augusto Soares
  • Tatiane Cristina Rodrigues
  • Giovana Tardin Torrezan
  • Felipe Cavalcanti Carneiro da Silva
  • Mev Dominguez Valentin
  • Maria Aparecida Azevedo Koike Folgueira
  • Bianca Costa Soares de Sá
  • Maria Isabel Waddington Achatz
  • Felipe Carneiro da Silva
  • Erika Maria Monteiro Santos
  • Elen Pereira Bastos
  • Maria Lucia Hirata Katayama
  • Patricia Bortman Rozenchan
  • Luciana Facure Moredo
  • Alexandre Leon Ribeiro de Ávila
  • Erica Sara Souza de Araújo
  • Maria do Socorro Maciel
  • Isabela Werneck da Cunha
  • César Henrique Torres
  • Carolina Sens-Abuázar
  • Ana Cv Krepischi
  • Antônio Hugo José Fróes Marques Campos
  • Erika Maria Monteiro dos Santos
  • Wilson Toshihiko Nakagawa
  • Samuel Aguiar Junior
  • Ligia Petrolini de Oliveira
  • Mariana Petaccia Macedo
  • Giovana T Torrezan
  • Rosângela Portilho Costa Santos
  • Isabela Werneck Cunha
  • Fabio de Oliveira Ferreira
  • Sabrina Daniela da Silva
  • Victor Piana de Andrade
  • Amanda Gonçalves Silva
  • Mabel Pinilla
  • Luciana Moredo Facure
  • João Pereira Duprat
  • Elimar Elias Gomes
  • João Pedreira Duprat Neto
  • Renato David Puga
  • Carlos Alberto de Bragança Pereira
  • Gilles Landman
  • Henrique Cursino Vieira
  • Amanda França de Nóbrega
  • Cecília Maria Lima da Costa
  • Aderbal Ruy T Silva
  • Hellen Kuasne
  • Ariane Machado-Lima
  • Fatima Solange Pasini
  • Fábio Albuquerque Marchi
  • Amanda Rusiska Piovezani
  • Talita Ferreira Marques Aguiar
  • Eloisa Helena Ribeiro Olivieri
  • João Pedreira Duprat
  • Elisa Napolitano E Ferreira
  • Louise Danielle De Carvalho Mota
  • Maria Isabel W Achatz
  • Andre Abreu Silva
  • Erika Mm Santos
  • Ricardo Renzo Brentani
  • Nadia Pereira Castro
  • Eloísa Ribeiro Olivieri
  • Amanda F Nóbrega
  • Vera Cristina Prescinoti
  • Rafael Malagoli Rocha
  • Luiz Paulo Camargo
  • Angela M Vianna-Morgante
  • Ricardo R Brentani
  • Fábio de Oliveira Ferreira
  • Victor Evangelista de Faria Ferraz
  • Bianca Cg Lisboa
  • Tatiana Iervolino Ricca
  • Felipe Carneiro
  • Silvia S Costa
  • Wilson Araújo da Silva Júnior
  • Cynthia Aparecida Bueno Toledo Osório
  • Amanda Gonçalves
  • Diogo Patrão
  • Tiago M Santos
  • Peter L Pearson

Detail Information

Publications23

  1. pmc Germline DNA copy number variation in familial and early-onset breast cancer
    Ana Cv Krepischi
    National Institute of Science and Technology in Oncogenomics, AC Camargo Hospital, Rua Taguá 440, 01508 010, Sao Paulo, Brazil
    Breast Cancer Res 14:R24. 2012
    ..We evaluated the role of germline CNVs in breast cancer susceptibility, in particular those with low population frequencies (rare CNVs), which are more likely to cause disease."..
  2. pmc A novel SYBR-based duplex qPCR for the detection of gene dosage: detection of an APC large deletion in a familial adenomatous polyposis patient with an unusual phenotype
    Giovana Tardin Torrezan
    CIPE International Center of Research and Training A, C, Camargo Hospital, Rua Taguá, Sao Paulo, Brazil
    BMC Med Genet 13:55. 2012
    ..Large deletions in APC are a common cause of FAP; despite the existence of a variety of gene dosage detection methodologies, most are labor intensive and time and resource consuming...
  3. pmc Breakpoint characterization of a novel large intragenic deletion of MUTYH detected in a MAP patient: case report
    Giovana T Torrezan
    International Center of Research and Training CIPE, A, C, Camargo Hospital, Sao Paulo, SP, Brazil
    BMC Med Genet 12:128. 2011
    ..Most MUTYH pathogenic variants are missense mutations, and until recently no gross genomic deletions had been described...
  4. pmc Poly (A)+ transcriptome assessment of ERBB2-induced alterations in breast cell lines
    Dirce Maria Carraro
    Centro Internacional de Ensino e Pesquisa, Hospital AC Camargo, Sao Paulo, Sao Paulo, Brazil
    PLoS ONE 6:e21022. 2011
    ....
  5. pmc Influence of the interaction between nodal fibroblast and breast cancer cells on gene expression
    Rosângela Portilho Costa Santos
    Departamento de Radiologia e Oncologia, LIM24, Faculdade de Medicina, Universidade de Sao Paulo, Avenida Dr Arnaldo, 455, 4º andar, sala 4124, CEP 01246 903 Sao Paulo, SP, Brazil
    Tumour Biol 32:145-57. 2011
    ..However, fibroblasts effects are distinct in each one of the breast cancer lineages, suggesting that the inter-relationships between stromal and malignant cells are dependent on the intrinsic subtype of the tumor...
  6. doi Lymphovascular invasion and histologic grade are associated with specific genomic profiles in invasive carcinomas of the breast
    Felipe Fidalgo
    International Research Center, AC Camargo Cancer Center, Sao Paulo, Brazil
    Tumour Biol 36:1835-48. 2015
    ..The data has shed some light on the molecular players involved in two highly relevant prognostic factors and may further add to the understanding of the mechanisms of breast cancer aggressiveness. ..
  7. doi Upregulated genes at 2q24 gains as candidate oncogenes in hepatoblastomas
    Tatiane Cristina Rodrigues
    Department of Genetics and Evolutionary Biology, Institute of Biosciences, University of Sao Paulo, Sao Paulo, Brazil
    Future Oncol 10:2449-57. 2014
    ..High-resolution cytogenetics may provide clues to hepatoblastoma tumorigenesis and indicate markers with clinical significance...
  8. pmc Comprehensive analysis of BRCA1, BRCA2 and TP53 germline mutation and tumor characterization: a portrait of early-onset breast cancer in Brazil
    Dirce Maria Carraro
    Laboratory of Genomics and Molecular Biology, A C Camargo Hospital, Sao Paulo, Brazil
    PLoS ONE 8:e57581. 2013
    ..Additionally, the data revealed molecular factors that potentially trigger the tumor development in young patients...
  9. pmc MicroRNAs discriminate familial from sporadic non-BRCA1/2 breast carcinoma arising in patients ≤35 years
    Elen Pereira Bastos
    Oncology and Radiology Department, Laboratory of Medical Investigation 24 LIM 24, University of Sao Paulo, Medical School, Sao Paulo, Brazil
    PLoS ONE 9:e101656. 2014
    ..MiR-mRNA co-expression analysis allowed us to identify changes in the miR-mRNA regulation that were able to distinguish tumors from familial and sporadic young BC patients non-carriers of BRCA mutations. ..
  10. doi Germline CDKN2A mutations in Brazilian patients of hereditary cutaneous melanoma
    Alexandre Leon Ribeiro de Ávila
    Department of Skin Câncer, AC Camargo Cancer Center, Sao Paulo, Brazil
    Fam Cancer 13:645-9. 2014
    ..This consideration should be taken into account when referring patients for genetic screening in a setting of limited budget, such as in developing countries. ..
  11. doi Reciprocal changes in gene expression profiles of cocultured breast epithelial cells and primary fibroblasts
    Patricia Bortman Rozenchan
    Disciplina de Oncologia, Departamento de Radiologia, Faculdade de Medicina da Universidade de Sao Paulo, Hospital A C Camargo, Av Dr Arnaldo, 455, Sala 4112, Sao Paulo, SP CEP 01246 903, Brazil
    Int J Cancer 125:2767-77. 2009
    ..Our data indicate that interactions between breast fibroblasts and basal epithelial cells resulted in alterations in the genomic profiles of both cell types which may help to clarify some aspects of this heterotypic signaling...
  12. pmc Predictive models for mutations in mismatch repair genes: implication for genetic counseling in developing countries
    Erika Maria Monteiro Santos
    Graduation Program, AC Camargo Hospital, Sao Paulo, Brazil
    BMC Cancer 12:64. 2012
    ..This study aims to evaluate sensitivity and specificity of five predictive models for germline mutations in repair genes in a sample of individuals with suspected Lynch syndrome...
  13. doi Characterization of germline mutations of MLH1 and MSH2 in unrelated south American suspected Lynch syndrome individuals
    Mev Dominguez Valentin
    Laboratory of Genomics and Molecular Biology, Centro Internacional de Pesquisa e Ensino, A C Camargo Hospital, Sao Paulo, Brazil
    Fam Cancer 10:641-7. 2011
    ..The high rate of novel mutations demonstrates the importance of defining MLH1 and MSH2 mutations in distinct LS populations...
  14. doi Clinicopathological significance of ubiquitin-specific protease 2a (USP2a), fatty acid synthase (FASN), and ErbB2 expression in oral squamous cell carcinomas
    Sabrina Daniela da Silva
    Department of Oral Diagnosis, School of Dentistry of Piracicaba, State University of Campinas UNICAMP, Av Limeira 901, CP52, Areão, Piracicaba, CEP 13414 018, Sao Paulo, Brazil
    Oral Oncol 45:e134-9. 2009
    ..0001, respectively). Taken together, the results presented here suggest a molecular connection among FASN, ErbB2, and USP2a in OSCC since their mRNA and protein levels were associated with tumor progression and poor prognosis...
  15. ncbi Alternative splicing: a bioinformatics perspective
    Elisa Napolitano Ferreira
    Ludwig Institute for Cancer Research, Sao Paulo Branch, Hospital A C Camargo, Sao Paulo, Brazil
    Mol Biosyst 3:473-7. 2007
    ..In this review, we discuss several issues related to alternative splicing with a special emphasis on identification strategies based on bioinformatics...
  16. doi Genome-wide DNA methylation profile of leukocytes from melanoma patients with and without CDKN2A mutations
    Erica Sara Souza de Araújo
    International Center for Research, A C Camargo Cancer Center, Sao Paulo, Brazil
    Exp Mol Pathol 97:425-32. 2014
    ..Thus, further studies are required to elucidate the impact of these findings on melanoma predisposition and their possible effect on the penetrance of CDKN2A mutations. ..
  17. doi Multiple mutations in the Kras gene in colorectal cancer: review of the literature with two case reports
    Mariana Petaccia Macedo
    Department of Pathology, Hospital A C Camargo, Sao Paulo, Brazil
    Int J Colorectal Dis 26:1241-8. 2011
    ..Few data exist on MMs with regard to their frequency and the codons and amino acids that are affected. We report two cases of Kras double mutations in codons 12 and 13 and review Kras MMs in primary CRC in PubMed databases...
  18. ncbi Gene expression profile of residual breast cancer after doxorubicin and cyclophosphamide neoadjuvant chemotherapy
    Maria Aparecida Azevedo Koike Folgueira
    Faculdade de Medicina da Universidade de Sao Paulo, Departamento de Radiologia, Disciplina de Oncologia, Sao Paulo, SP, Brasil
    Oncol Rep 22:805-13. 2009
    ..CTGF and DUSP1 overexpression in residual samples may be a reflection of resistance to further administration of AC regimen...
  19. doi Association of melanoma with intraepithelial neoplasia of the pancreas in three patients
    Felipe Fidalgo
    International Research Center, AC Camargo Cancer Center, Sao Paulo, Brazil
    Exp Mol Pathol 97:144-7. 2014
    ..Our data pinpoint that rare germline CNVs harboring genes can contribute to the cancer predisposition of melanoma and intraepithelial neoplasia of the pancreas...
  20. ncbi The value of a tumor bank in the development of cancer research in Brazil: 13 years of experience at the a C camargo hospital
    Antônio Hugo José Fróes Marques Campos
    1 A C Camargo Hospital Biobank, A C Camargo Hospital Antonio Prudente Foundation, Sao Paulo, SP, Brazil
    Biopreserv Biobank 10:168-73. 2012
    ..We conclude that biobanking should be part of the strategy employed by scientists and research institutions dedicated to the study of human diseases. ..
  21. pmc Mutational spectrum of the APC and MUTYH genes and genotype-phenotype correlations in Brazilian FAP, AFAP, and MAP patients
    Giovana Tardin Torrezan
    Laboratory of Genomics and Molecular Biology, A C Camargo Hospital, Sao Paulo, SP, Brazil
    Orphanet J Rare Dis 8:54. 2013
    ..The spectrum of mutations as well as the genotype-phenotype correlations in polyposis syndromes present clinical impact and can be population specific, making important to obtain genetic and clinical data from different populations...
  22. ncbi Mismatch repair genes in Lynch syndrome: a review
    Felipe Cavalcanti Carneiro da Silva
    Hospital AC Camargo, Sao Paulo, Brazil
    Sao Paulo Med J 127:46-51. 2009
    ....
  23. pmc Down-regulation of ANAPC13 and CLTCL1: Early Events in the Progression of Preinvasive Ductal Carcinoma of the Breast
    Carolina Sens-Abuázar
    Laboratory of Genomics and Molecular Biology, International Center of Research and Teaching, A C Camargo Hospital, Sao Paulo, SP, Brazil
    Transl Oncol 5:113-23. 2012
    ..1-1q32.1), 8q, and 17q (17q24.2), regions that display common imbalances in breast tumors, suggesting that down-regulation of ANAPC13 contributes to genomic instability in this disease...