Peter Carmeliet

Summary

Publications

  1. doi request reprint Molecular mechanisms and clinical applications of angiogenesis
    Peter Carmeliet
    Laboratory of Angiogenesis and Neurovascular Link, Vesalius Research Center, VIB, Leuven B 3000, Belgium
    Nature 473:298-307. 2011
  2. doi request reprint VEGF ligands and receptors: implications in neurodevelopment and neurodegeneration
    Peter Carmeliet
    Laboratory of Angiogenesis and Neurovascular Link, Vesalius Research Center, K U Leuven, 3000, Leuven, Belgium
    Cell Mol Life Sci 70:1763-78. 2013
  3. doi request reprint Treating diabetes by blocking a vascular growth factor
    Peter Carmeliet
    Department of Oncology, University of Leuven, Leuven, Belgium, Laboratory of Angiogenesis and Neurovascular Link, Vesalius Research Center, B 3000, Leuven, Belgium VIB, Leuven, Belgium, Laboratory of Angiogenesis and Neurovascular Link, Vesalius Research Center, B 3000, Leuven, Belgium Electronic address
    Cell Metab 16:553-5. 2012
  4. pmc Prevention of elastase-induced emphysema in placenta growth factor knock-out mice
    Shih Lung Cheng
    Department of Internal Medicine, Far Eastern Memorial Hospital, Taiwan
    Respir Res 10:115. 2009
  5. doi request reprint Principles and mechanisms of vessel normalization for cancer and other angiogenic diseases
    Peter Carmeliet
    Vesalius Research Center, VIB, K U Leuven, Campus Gasthuisberg, Herestraat 49, B 3000 Leuven, Belgium
    Nat Rev Drug Discov 10:417-27. 2011
  6. pmc Soluble VEGF isoforms are essential for establishing epiphyseal vascularization and regulating chondrocyte development and survival
    Christa Maes
    Laboratory of Experimental Medicine and Endocrinology, Katholieke Universiteit Leuven, Leuven, Belgium
    J Clin Invest 113:188-99. 2004
  7. pmc Increased skeletal VEGF enhances beta-catenin activity and results in excessively ossified bones
    Christa Maes
    Laboratory of Experimental Medicine and Endocrinology, Department of Experimental Medicine, KU Leuven, Leuven, Belgium
    EMBO J 29:424-41. 2010
  8. pmc Reevaluation of the role of VEGF-B suggests a restricted role in the revascularization of the ischemic myocardium
    Xuri Li
    Vesalius Research Center, VIB, 3000 Leuven, Belgium
    Arterioscler Thromb Vasc Biol 28:1614-20. 2008
  9. doi request reprint Role of delta-like-4/Notch in the formation and wiring of the lymphatic network in zebrafish
    Ilse Geudens
    Vesalius Research Center, VIB, Leuven, Belgium
    Arterioscler Thromb Vasc Biol 30:1695-702. 2010
  10. ncbi request reprint Revascularization of ischemic tissues by PlGF treatment, and inhibition of tumor angiogenesis, arthritis and atherosclerosis by anti-Flt1
    Aernout Luttun
    Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, University of Leuven, Leuven, Belgium
    Nat Med 8:831-40. 2002

Detail Information

Publications96

  1. doi request reprint Molecular mechanisms and clinical applications of angiogenesis
    Peter Carmeliet
    Laboratory of Angiogenesis and Neurovascular Link, Vesalius Research Center, VIB, Leuven B 3000, Belgium
    Nature 473:298-307. 2011
    ..Recent preclinical and clinical studies have shown new molecular targets and principles, which may provide avenues for improving the therapeutic benefit from anti-angiogenic strategies...
  2. doi request reprint VEGF ligands and receptors: implications in neurodevelopment and neurodegeneration
    Peter Carmeliet
    Laboratory of Angiogenesis and Neurovascular Link, Vesalius Research Center, K U Leuven, 3000, Leuven, Belgium
    Cell Mol Life Sci 70:1763-78. 2013
    ..We also discuss recent findings demonstrating that other VEGF ligands influence processes such as neurogenesis and dendrite arborization and participate in neurodegeneration...
  3. doi request reprint Treating diabetes by blocking a vascular growth factor
    Peter Carmeliet
    Department of Oncology, University of Leuven, Leuven, Belgium, Laboratory of Angiogenesis and Neurovascular Link, Vesalius Research Center, B 3000, Leuven, Belgium VIB, Leuven, Belgium, Laboratory of Angiogenesis and Neurovascular Link, Vesalius Research Center, B 3000, Leuven, Belgium Electronic address
    Cell Metab 16:553-5. 2012
    ..2012) report that targeting the vascular endothelial growth factor (VEGF)-B restores insulin sensitivity and glucose tolerance by inhibiting endothelial-to-tissue lipid transport, opening promising avenues for diabetes therapy...
  4. pmc Prevention of elastase-induced emphysema in placenta growth factor knock-out mice
    Shih Lung Cheng
    Department of Internal Medicine, Far Eastern Memorial Hospital, Taiwan
    Respir Res 10:115. 2009
    ..This study hypothesizes that blocking PlGF prevents the development of emphysema...
  5. doi request reprint Principles and mechanisms of vessel normalization for cancer and other angiogenic diseases
    Peter Carmeliet
    Vesalius Research Center, VIB, K U Leuven, Campus Gasthuisberg, Herestraat 49, B 3000 Leuven, Belgium
    Nat Rev Drug Discov 10:417-27. 2011
    ..Here, we discuss the mechanisms, benefits, limitations and possible clinical translation of vessel normalization for cancer and other angiogenic disorders...
  6. pmc Soluble VEGF isoforms are essential for establishing epiphyseal vascularization and regulating chondrocyte development and survival
    Christa Maes
    Laboratory of Experimental Medicine and Endocrinology, Katholieke Universiteit Leuven, Leuven, Belgium
    J Clin Invest 113:188-99. 2004
    ..These findings indicate that the insoluble VEGF(188) isoform is insufficient for establishing epiphyseal vascularization and regulating cartilage development during endochondral bone formation...
  7. pmc Increased skeletal VEGF enhances beta-catenin activity and results in excessively ossified bones
    Christa Maes
    Laboratory of Experimental Medicine and Endocrinology, Department of Experimental Medicine, KU Leuven, Leuven, Belgium
    EMBO J 29:424-41. 2010
    ..Moreover, the finding that VEGF can modulate beta-catenin activity may have widespread physiological and clinical ramifications...
  8. pmc Reevaluation of the role of VEGF-B suggests a restricted role in the revascularization of the ischemic myocardium
    Xuri Li
    Vesalius Research Center, VIB, 3000 Leuven, Belgium
    Arterioscler Thromb Vasc Biol 28:1614-20. 2008
    ..The endogenous role of the VEGF family member vascular endothelial growth factor-B (VEGF-B) in pathological angiogenesis remains unclear...
  9. doi request reprint Role of delta-like-4/Notch in the formation and wiring of the lymphatic network in zebrafish
    Ilse Geudens
    Vesalius Research Center, VIB, Leuven, Belgium
    Arterioscler Thromb Vasc Biol 30:1695-702. 2010
    ..To study whether Notch signaling, which regulates cell fate decisions and vessel morphogenesis, controls lymphatic development...
  10. ncbi request reprint Revascularization of ischemic tissues by PlGF treatment, and inhibition of tumor angiogenesis, arthritis and atherosclerosis by anti-Flt1
    Aernout Luttun
    Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, University of Leuven, Leuven, Belgium
    Nat Med 8:831-40. 2002
    ..Thus, PlGF and Flt1 constitute potential candidates for therapeutic modulation of angiogenesis and inflammation...
  11. ncbi request reprint Role of vascular endothelial growth factor and placental growth factor in basal adhesion formation and in carbon dioxide pneumoperitoneum-enhanced adhesion formation after laparoscopic surgery in transgenic mice
    Carlos Roger Molinas
    Center for Surgical Technologies, Katholieke Universiteit Leuven, Leuven, Belgium
    Fertil Steril 80:803-11. 2003
    ..To evaluate the role of vascular endothelial growth factor (VEGF) and placental growth factor (PlGF) in adhesion formation after laparoscopic surgery...
  12. doi request reprint Malignant cells fuel tumor growth by educating infiltrating leukocytes to produce the mitogen Gas6
    Sonja Loges
    Vesalius Research Center VRC, Vlaams Instituut voor Biotechnologie VIB, Leuven, Belgium
    Blood 115:2264-73. 2010
    ..Hence, inhibition of Gas6 might offer novel opportunities for the treatment of cancer...
  13. pmc Role of synectin in lymphatic development in zebrafish and frogs
    Karlien Hermans
    Vesalius Research Center, Vlaams Iustituut voor Biotechnologie, Katholieke Universiteit Leuven, Campus Gasthuisberg, Herestraat 49, Leuven, Belgium
    Blood 116:3356-66. 2010
    ..These findings reveal a novel role for synectin in lymphatic development...
  14. ncbi request reprint Anti-PlGF inhibits growth of VEGF(R)-inhibitor-resistant tumors without affecting healthy vessels
    Christian Fischer
    Department for Transgene Technology and Gene Therapy, VIB, 3000, Leuven, Belgium
    Cell 131:463-75. 2007
    ..The efficacy and safety of alphaPlGF, its pleiotropic and complementary mechanism to VEGF(R)Is, and the negligible induction of an angiogenic rescue program suggest that alphaPlGF may constitute a novel approach for cancer treatment...
  15. doi request reprint Matrix-binding vascular endothelial growth factor (VEGF) isoforms guide granule cell migration in the cerebellum via VEGF receptor Flk1
    Carmen Ruiz de Almodovar
    Vesalius Research Center, Vlaams Instituut voor Biotechnologie, Vesalius Research Center, Katholieke Universiteit Leuven, Belgium
    J Neurosci 30:15052-66. 2010
    ..These findings identify a previously unknown role for VEGF in neuronal migration...
  16. ncbi request reprint Role of PlGF in the intra- and intermolecular cross talk between the VEGF receptors Flt1 and Flk1
    Monica Autiero
    The Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, KULeuven, Leuven, B 3000, Belgium
    Nat Med 9:936-43. 2003
    ....
  17. doi request reprint Anti-placental growth factor reduces bone metastasis by blocking tumor cell engraftment and osteoclast differentiation
    Lieve Coenegrachts
    Laboratory of Experimental Medicine and Endocrinology, Vesalius Research Center, KU Leuven, Belgium
    Cancer Res 70:6537-47. 2010
    ..These findings identify novel properties of PlGF and suggest that alphaPlGF might offer opportunities for adjuvant therapy of bone metastasis...
  18. doi request reprint Fibrinolysis-independent role of plasmin and its activators in the haematopoietic recovery after myeloablation
    Marc Tjwa
    Vesalius Research Center, VIB, Leuven, Belgium
    J Cell Mol Med 13:4587-95. 2009
    ..These findings provide novel insights in how plasmin regulates haematopoietic recovery upon cytotoxic myeloablation...
  19. doi request reprint Heterozygous deficiency of PHD2 restores tumor oxygenation and inhibits metastasis via endothelial normalization
    Massimiliano Mazzone
    Vesalius Research Center, VIB Vlaams Instituut voor Biotechnologie, Leuven, Belgium
    Cell 136:839-51. 2009
    ..Inhibition of PHD2 may offer alternative therapeutic opportunities for anticancer therapy...
  20. doi request reprint Novel role for vascular endothelial growth factor (VEGF) receptor-1 and its ligand VEGF-B in motor neuron degeneration
    Koen Poesen
    Vesalius Research Center, Katholieke Universiteit Leuven, Leuven B 3000, Belgium
    J Neurosci 28:10451-9. 2008
    ..The neuroprotective activity of VEGF-B, in combination with its negligible angiogenic/permeability activity, offers attractive opportunities for the treatment of neurodegenerative diseases...
  21. doi request reprint Transcription factor COUP-TFII is indispensable for venous and lymphatic development in zebrafish and Xenopus laevis
    Xabier L Aranguren
    Center for Molecular and Vascular Biology, Katholieke Universiteit Leuven, Campus Gasthuisberg, Onderwijs and Navorsing 1, Herestraat 49, B 3000 Leuven, Belgium
    Biochem Biophys Res Commun 410:121-6. 2011
    ..Therefore, the role of NR2F2 in EC fate determination is evolutionary conserved...
  22. pmc Vitamin D receptor in chondrocytes promotes osteoclastogenesis and regulates FGF23 production in osteoblasts
    Ritsuko Masuyama
    Laboratory of Experimental Medicine and Endocrinology, Katholieke Universiteit Leuven, Leuven, Belgium
    J Clin Invest 116:3150-9. 2006
    ..Taken together, our findings provide evidence that VDR signaling in chondrocytes is required for timely osteoclast formation during bone development and for the endocrine action of bone in phosphate homeostasis...
  23. doi request reprint Short-term delivery of anti-PlGF antibody delays progression of atherosclerotic plaques to vulnerable lesions
    Carmen Roncal
    Vesalius Research Center, VIB, KULeuven, Campus Gasthuisberg, Herestraat 49, Box 912, 3000 Leuven, Belgium
    Cardiovasc Res 86:29-36. 2010
    ..Previous gene-inactivation studies revealed that the loss of PlGF delays atherosclerotic lesion development and inhibits macrophage infiltration, but the activity of an anti-PlGF antibody (alphaPlGF mAb) has not been evaluated yet...
  24. ncbi request reprint VEGF: a modifier of the del22q11 (DiGeorge) syndrome?
    Ingeborg Stalmans
    The Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, Katholieke Universiteit Leuven, Leuven, Belgium
    Nat Med 9:173-82. 2003
    ..These genetic data in mouse, fish and human indicate that VEGF is a modifier of cardiovascular birth defects in the del22q11 syndrome...
  25. pmc Revascularization of ischemic tissues by PDGF-CC via effects on endothelial cells and their progenitors
    Xuri Li
    The Center for Transgene Technology and Gene Therapy, Flanders Interuniversitary Institute for Biotechnology VIB, University of Leuven, Leuven, Belgium
    J Clin Invest 115:118-27. 2005
    ..Moreover, delivery of PDGF-CC enhanced postischemic revascularization of the heart and limb. Modulating the activity of PDGF-CC may provide novel opportunities for treating ischemic diseases...
  26. doi request reprint Impaired autonomic regulation of resistance arteries in mice with low vascular endothelial growth factor or upon vascular endothelial growth factor trap delivery
    Erik Storkebaum
    Vesalius Research Center, KU Leuven and VIB, Leuven, Belgium
    Circulation 122:273-81. 2010
    ..Control of peripheral resistance arteries by autonomic nerves is essential for the regulation of blood flow. The signals responsible for the maintenance of vascular neuroeffector mechanisms in the adult, however, remain largely unknown...
  27. ncbi request reprint Gas6 promotes inflammation by enhancing interactions between endothelial cells, platelets, and leukocytes
    Marc Tjwa
    Department of Transgene Technology and Gene Therapy, Flanders Institute of Biotechnology VIB, Leuven, Belgium
    Blood 111:4096-105. 2008
    ..Thus, Gas6 amplifies EC activation, thereby playing a key role in enhancing the interactions between ECs, platelets, and leukocytes during inflammation...
  28. ncbi request reprint Cardia bifida, defective heart development and abnormal neural crest migration in embryos lacking hypoxia-inducible factor-1alpha
    Veerle Compernolle
    Flanders Interuniversitary Institute for Biotechnology, KU Leuven, Campus Gasthuisberg, Herestraat 49, B 3000 Leuven, Belgium
    Cardiovasc Res 60:569-79. 2003
    ..We attempted to further characterize the underlying mechanisms resulting in abnormal cardiogenesis and defective angiogenesis in mice deficient for HIF-1alpha (HIF-1alpha(-/-))...
  29. doi request reprint Engineering vascularized bone: osteogenic and proangiogenic potential of murine periosteal cells
    Nick van Gastel
    Laboratory of Clinical and Experimental Endocrinology, Division of Skeletal Tissue Engineering, KU Leuven, Leuven, Belgium
    Stem Cells 30:2460-71. 2012
    ....
  30. doi request reprint VEGF-D deficiency in mice does not affect embryonic or postnatal lymphangiogenesis but reduces lymphatic metastasis
    Marta Koch
    Vesalius Research Centre, VIB, B 3000 Leuven, Belgium
    J Pathol 219:356-64. 2009
    ....
  31. ncbi request reprint VEGF: once regarded as a specific angiogenic factor, now implicated in neuroprotection
    Erik Storkebaum
    Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, University of Leuven, Belgium
    Bioessays 26:943-54. 2004
    ..These findings have raised growing interest in assessing the therapeutic potential of VEGF for neurodegenerative disorders...
  32. ncbi request reprint Loss of placental growth factor protects mice against vascular permeability in pathological conditions
    Aernout Luttun
    The Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, KU Leuven, Leuven B 3000, Belgium
    Biochem Biophys Res Commun 295:428-34. 2002
    ..These findings suggest that inhibition of PlGF might be an attractive tool to reduce vascular leakage in various diseases...
  33. pmc Placental growth factor mediates mesenchymal cell development, cartilage turnover, and bone remodeling during fracture repair
    Christa Maes
    Laboratory of Experimental Medicine and Endocrinology, Katholieke Universiteit Leuven, Leuven, Belgium
    J Clin Invest 116:1230-42. 2006
    ..Therefore PlGF may potentially offer therapeutic advantages for fracture repair...
  34. pmc VEGF mediates commissural axon chemoattraction through its receptor Flk1
    Carmen Ruiz de Almodovar
    VIB, Laboratory for Angiogenesis and the Neurovascular link, Vesalius Research Center, KULeuven, Leuven, Belgium
    Neuron 70:966-78. 2011
    ..Similar to Shh and Netrin-1, VEGF-mediated commissural axon guidance requires the activity of Src family kinases. Our results identify VEGF and Flk1 as a novel ligand/receptor pair controlling commissural axon guidance...
  35. ncbi request reprint Impaired adipose tissue development in mice with inactivation of placental growth factor function
    H Roger Lijnen
    Center for Molecular and Vascular Biology, KU Leuven, Campus Gasthuisberg, O and N 1, Box 911, Herestraat 49, B 3000 Leuven, Belgium
    Diabetes 55:2698-704. 2006
    ..Thus, in murine models of diet-induced obesity, inactivation of PlGF impairs adipose tissue development, at least in part as a result of reduced angiogenesis...
  36. doi request reprint From vessel sprouting to normalization: role of the prolyl hydroxylase domain protein/hypoxia-inducible factor oxygen-sensing machinery
    Cathy Coulon
    Vesalius Research Center, Vlaams Instituut voor Biotechnologie, Katholieke Universiteit Leuven, Campus Gasthuisberg, Herestraat 49, B 3000 Leuven, Belgium
    Arterioscler Thromb Vasc Biol 30:2331-6. 2010
    ..Given the essential role of hypoxia as the driving force for initiating angiogenesis, it is not surprising that the hypoxia-sensing machinery controls key steps in physiological and pathological angiogenesis...
  37. ncbi request reprint Treatment of motoneuron degeneration by intracerebroventricular delivery of VEGF in a rat model of ALS
    Erik Storkebaum
    The Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology VIB, KU Leuven, Leuven B 3000, Belgium
    Nat Neurosci 8:85-92. 2005
    ..On i.c.v. delivery, Vegf is anterogradely transported and preserves neuromuscular junctions in SOD1(G93A) rats. Our findings in preclinical rodent models of ALS may have implications for treatment of neurodegenerative disease in general...
  38. ncbi request reprint VEGF is a modifier of amyotrophic lateral sclerosis in mice and humans and protects motoneurons against ischemic death
    Diether Lambrechts
    The Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology and Department of Neurology, University Hospital Gasthuisberg, KU Leuven, Leuven, B 3000, Belgium
    Nat Genet 34:383-94. 2003
    ..These findings indicate that VEGF is a modifier of motoneuron degeneration in human ALS and unveil a therapeutic potential of Vegfa for stressed motoneurons in mice...
  39. pmc Loss or inhibition of uPA or MMP-9 attenuates LV remodeling and dysfunction after acute pressure overload in mice
    Stephane Heymans
    Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute, Herestraat 49, B 3000 Leuven, Belgium
    Am J Pathol 166:15-25. 2005
    ..Deficiency of MMP-9 had an intermediate effect. These findings suggest that the use of u-PA- or MMP-inhibitors might preserve cardiac pump function in LV pressure overloading...
  40. ncbi request reprint Blood vessels and nerves: common signals, pathways and diseases
    Peter Carmeliet
    Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, Katholieke Universiteit Leuven, Campus Gasthuisberg, Herestraat 49, B 3000, Leuven, Belgium
    Nat Rev Genet 4:710-20. 2003
    ..The realization that both systems use common genetic pathways should not only form links between vascular biology and neuroscience, but also promises to accelerate the discovery of new mechanistic insights and therapeutic opportunities...
  41. doi request reprint Gene-targeting of Phd2 improves tumor response to chemotherapy and prevents side-toxicity
    Rodrigo Leite De Oliveira
    Lab of Molecular Oncology and Angiogenesis, Vesalius Research Center, VIB, 3000 Leuven, Belgium
    Cancer Cell 22:263-77. 2012
    ..Altogether, our study discloses alternative strategies for chemotherapy optimization...
  42. pmc Membrane-anchored uPAR regulates the proliferation, marrow pool size, engraftment, and mobilization of mouse hematopoietic stem/progenitor cells
    Marc Tjwa
    VIB Vesalius Research Center, Katholieke Universiteit Leuven, Leuven, Belgium
    J Clin Invest 119:1008-18. 2009
    ..These findings identify MuPAR and plasmin as regulators of the proliferation, marrow pool size, homing, engraftment, and mobilization of HSPCs and possibly also of HSCs...
  43. doi request reprint Further pharmacological and genetic evidence for the efficacy of PlGF inhibition in cancer and eye disease
    Sara Van de Veire
    Vesalius Research Center, KU Leuven, Leuven B 3000, Belgium
    Cell 141:178-90. 2010
    ..Further, we show that PlGF blockage inhibits vessel abnormalization rather than density in certain tumors while enhancing VEGF-targeted inhibition in ocular disease. Our findings warrant further testing of anti-PlGF therapies...
  44. ncbi request reprint A novel role for vascular endothelial growth factor as an autocrine survival factor for embryonic stem cells during hypoxia
    Koen Brusselmans
    Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology VIB, KULeuven, Leuven, B 3000, Belgium
    J Biol Chem 280:3493-9. 2005
    ..Thus, VEGF plays a critical role in survival of ES cells during prolonged hypoxia...
  45. doi request reprint Role of VEGF-D and VEGFR-3 in developmental lymphangiogenesis, a chemicogenetic study in Xenopus tadpoles
    Annelii Ny
    Vesalius Research Center, VIB KU Leuven, Leuven, Belgium
    Blood 112:1740-9. 2008
    ..These findings document a critical role of VEGFR-3 in embryonic lymphatic development and function, and reveal a previously unrecognized modifier role of VEGF-D in the regulation of embryonic lymphangiogenesis in frog embryos...
  46. pmc Progranulin functions as a neurotrophic factor to regulate neurite outgrowth and enhance neuronal survival
    Philip Van Damme
    Laboratory of Neurobiology, Flanders Interuniversity Institute for Biotechnology, Katholieke Universiteit Leuven, Campus Gasthuisberg, 3000 Leuven, Belgium
    J Cell Biol 181:37-41. 2008
    ..These results demonstrate that PGRN/GRN is a neurotrophic factor with activities that may be involved in the development of the nervous system and in neurodegeneration...
  47. pmc Astrocytes regulate GluR2 expression in motor neurons and their vulnerability to excitotoxicity
    Philip Van Damme
    Laboratory of Neurobiology, Flanders Interuniversity Institute for Biotechnology, University of Leuven, B 3000 Leuven, Belgium
    Proc Natl Acad Sci U S A 104:14825-30. 2007
    ..These results reveal a mechanism through which astrocytes influence neuronal functioning in health and disease...
  48. ncbi request reprint Role of hypoxia inducible factors 1alpha and 2alpha in basal adhesion formation and in carbon dioxide pneumoperitoneum-enhanced adhesion formation after laparoscopic surgery in transgenic mice
    Carlos Roger Molinas
    Center for Surgical Technologies, Katholieke Universiteit Leuven, Leuven, Belgium
    Fertil Steril 80:795-802. 2003
    ..To evaluate the role of hypoxia inducible factors (HIFs) 1alpha and 2alpha in adhesion formation after laparoscopic surgery...
  49. ncbi request reprint Loss of matrix metalloproteinase-9 or matrix metalloproteinase-12 protects apolipoprotein E-deficient mice against atherosclerotic media destruction but differentially affects plaque growth
    Aernout Luttun
    Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, KULeuven, Leuven, Belgium
    Circulation 109:1408-14. 2004
    ..However, the role of specific MMPs, such as MMP-9 and MMP-12, in atherosclerosis remains undefined...
  50. doi request reprint Loss of the cholesterol-binding protein prominin-1/CD133 causes disk dysmorphogenesis and photoreceptor degeneration
    Serena Zacchigna
    Vesalius Research Center, Vlaams Instituut voor Biotechnologie, Katholieke Universiteit Leuven, B 3000 Leuven, Belgium
    J Neurosci 29:2297-308. 2009
    ..These findings shed novel insight on how Prom-1 regulates neural retinal development and phototransduction in vertebrates...
  51. ncbi request reprint Loss of HIF-2alpha and inhibition of VEGF impair fetal lung maturation, whereas treatment with VEGF prevents fatal respiratory distress in premature mice
    Veerle Compernolle
    The Center for Transgene Technology and Gene Therapy, Flanders Interuniversity, Institute for Biotechnology, Leuven, Belgium
    Nat Med 8:702-10. 2002
    ..The pneumotrophic effect of VEGF may have therapeutic potential for lung maturation in preterm infants...
  52. doi request reprint Food-restriction in obese dyslipidaemic diabetic mice partially restores basal contractility but not contractile reserve
    An Van den Bergh
    Department of Cardiovascular Diseases, Division of Experimental Cardiac Surgery, Katholieke Universiteit Leuven, Leuven, Belgium
    Eur J Heart Fail 11:1118-25. 2009
    ..However, their effect on contractile dysfunction and impaired cardiac functional reserve is unknown...
  53. ncbi request reprint Thrombophilia in mice expressing a tissue factor variant lacking its transmembrane and cytosolic domain
    Els Melis
    The Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology VIB, KULeuven Campus Gasthuisberg, Leuven B 3000, Belgium
    Biochem Biophys Res Commun 333:488-95. 2005
    ..This severe thrombotic phenotype associated with the presence of a non-anchored soluble TF variant underscores the recently recognized significance of circulating TF for thrombus formation and development...
  54. pmc The nuclear scaffold protein NIPP1 is essential for early embryonic development and cell proliferation
    Aleyde Van Eynde
    Division of Biochemistry, Center for Transgene Technology and Gene Therapy, Flanders Interuniversity, Institute for Biotechnology, Leuven, Belgium
    Mol Cell Biol 24:5863-74. 2004
    ..We conclude that NIPP1 is indispensable for early embryonic development and cell proliferation...
  55. ncbi request reprint Role of Gas-6 in adipogenesis and nutritionally induced adipose tissue development in mice
    Erik Maquoi
    Center for Molecular and Vascular Biology, KU Leuven, Leuven, Belgium
    Arterioscler Thromb Vasc Biol 25:1002-7. 2005
    ..A potential role of growth arrest-specific gene 6 (Gas-6) in energy storage in adipose tissue was investigated in murine models of obesity. Gas-6 is a ligand for the Axl, C-Mer, and Sky family of tyrosine kinase receptors...
  56. ncbi request reprint Angiogenesis and lymphangiogenesis: highlights of the past year
    Aernout Luttun
    Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, Leuven, Belgium
    Curr Opin Hematol 11:262-71. 2004
    ..The authors apologize for their inability, because of space restrictions, to reference all other relevant work of the past or previous years...
  57. pmc Neuronal FLT1 receptor and its selective ligand VEGF-B protect against retrograde degeneration of sensory neurons
    Joke Dhondt
    Vesalius Research Center, Katholieke Universiteit Leuven, Leuven, Belgium
    FASEB J 25:1461-73. 2011
    ..Overall, this indicates that VEGF-B, instead of acting as an angiogenic factor, exerts direct neuroprotective effects through FLT1. These findings also suggest a clinically relevant role for VEGF-B in preventing distal neuropathies...
  58. ncbi request reprint Genetic dissection of tumor angiogenesis: are PlGF and VEGFR-1 novel anti-cancer targets?
    Aernout Luttun
    The Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, KULeuven, Campus Gasthuisberg, Herestraat 49, B 3000 Leuven, Belgium
    Biochim Biophys Acta 1654:79-94. 2004
    ..Together, these insights may bring anti-angiogenic drugs closer from bench to bedside...
  59. ncbi request reprint VEGF and PlGF: two pleiotropic growth factors with distinct roles in development and homeostasis
    Marc Tjwa
    The Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, University of Leuven, 3000, Leuven, Belgium
    Cell Tissue Res 314:5-14. 2003
    ..These new insights broaden the activity spectrum of these "angiogenic" growth factors, and may have therapeutic implications when using these growth factors for vascular and/or non-vascular purposes...
  60. ncbi request reprint Role of vascular endothelial growth factor receptor 1 in basal adhesion formation and in carbon dioxide pneumoperitoneum-enhanced adhesion formation after laparoscopic surgery in mice
    Carlos Roger Molinas
    Department of Obstetrics and Gynecology, University Hospital Gasthuisberg, Katholieke Universiteit Leuven, Leuven, Belgium
    Fertil Steril 82:1149-53. 2004
    ..To evaluate the role of vascular endothelial growth factor receptor-1 (VEGFR-1) in adhesion formation after laparoscopic surgery...
  61. ncbi request reprint Similarities between angiogenesis and neural development: what small animal models can tell us
    Serena Zacchigna
    Department of Transgene Technology and Gene Therapy, VIB, Leuven, Belgium
    Curr Top Dev Biol 80:1-55. 2008
    ..In the first part of this chapter, we will discuss the more commonly used animal models; in the second part, the striking similarities occurring during the development of the vascular and the neural systems will be revised...
  62. doi request reprint Regulation of angiogenesis by oxygen and metabolism
    Peter Fraisl
    Vesalius Research Center, Leuven, Belgium
    Dev Cell 16:167-79. 2009
    ..We will highlight advances in how oxygen and metabolism regulate angiogenesis as well as how angiogenic factors in turn also regulate metabolism...
  63. doi request reprint Peroxisome deficient aP2-Pex5 knockout mice display impaired white adipocyte and muscle function concomitant with reduced adrenergic tone
    Katrin Martens
    Laboratory of Cell Metabolism, Department of Pharmaceutical Sciences, KU Leuven, Leuven, Belgium
    Mol Genet Metab 107:735-47. 2012
    ..We conclude that peroxisomal metabolism is necessary to maintain the adrenergic tone in mice, which in turn determines metabolic homeostasis...
  64. doi request reprint Systemic anti-vascular endothelial growth factor therapies induce a painful sensory neuropathy
    An Verheyen
    Laboratory for Translational Genetics, Department of Oncology, University of Leuven, B 3000 Leuven, Belgium
    Brain 135:2629-41. 2012
    ....
  65. doi request reprint Inhibition of oxygen sensors as a therapeutic strategy for ischaemic and inflammatory disease
    Peter Fraisl
    Vesalius Research Center, VIB, K U Leuven, Campus Gasthuisberg, Herestraat 49, B 3000 Leuven, Belgium
    Nat Rev Drug Discov 8:139-52. 2009
    ..Advances in understanding of the role of these oxygen sensors in hypoxia tolerance, ischaemic preconditioning and inflammation are creating new opportunities for pharmacological interventions for ischaemic and inflammatory diseases...
  66. doi request reprint Endothelial oxygen sensors regulate tumor vessel abnormalization by instructing phalanx endothelial cells
    Katrien De Bock
    Vesalius Research Center, K U Leuven, Belgium
    J Mol Med (Berl) 87:561-9. 2009
    ..This review discusses the role of PHD2 in the regulation of vessel (ab)normalization and the therapeutic potential of PHD2 inhibition for tumor invasiveness and metastasis...
  67. doi request reprint Role and therapeutic potential of VEGF in the nervous system
    Carmen Ruiz de Almodovar
    The Vesalius Research Center, KU Leuven and VIB, Leuven, Belgium
    Physiol Rev 89:607-48. 2009
    ..We describe the molecular properties of VEGF and its receptors and review the current knowledge of its different functions and therapeutic potential in the nervous system during development, health, disease and in medicine...
  68. ncbi request reprint Effects of vascular endothelial growth factor (VEGF) on motor neuron degeneration
    Ludo Van Den Bosch
    Laboratory for Neurobiology, Department of Experimental Neurology, School of Medicine, University of Leuven, Leuven, Belgium
    Neurobiol Dis 17:21-8. 2004
    ..Our results show that VEGF is a neurotrophic factor for motor neurons in vitro, and shortage of this neurotrophic factor may contribute to the motor neuron death observed in humans and animals with low VEGF expression levels...
  69. ncbi request reprint Overexpression of mutant superoxide dismutase 1 causes a motor axonopathy in the zebrafish
    Robin Lemmens
    Department of Neurology, University Hospital Gasthuisberg, K U Leuven, Belgium
    Hum Mol Genet 16:2359-65. 2007
    ....
  70. doi request reprint Loss or inhibition of stromal-derived PlGF prolongs survival of mice with imatinib-resistant Bcr-Abl1(+) leukemia
    Thomas Schmidt
    Laboratory of Angiogenesis and Neurovascular Link, Vesalius Research Center VRC, VIB, K U Leuven, Belgium
    Cancer Cell 19:740-53. 2011
    ..These results may warrant further investigation of the therapeutic potential of PlGF inhibition for (imatinib-resistant) CML...
  71. doi request reprint Branching morphogenesis and antiangiogenesis candidates: tip cells lead the way
    Peter Carmeliet
    Vesalius Research Center, VIB, KULeuven, Campus Gasthuisberg, Herestraat 49, Leuven, Belgium
    Nat Rev Clin Oncol 6:315-26. 2009
    ..This Review provides a conceptual framework in which molecular discoveries and principles are discussed in light of clinical opportunities to develop new antiangiogenic agents...
  72. doi request reprint Silencing or fueling metastasis with VEGF inhibitors: antiangiogenesis revisited
    Sonja Loges
    Vesalius Research Center, VIB, B 3000 Leuven, Belgium
    Cancer Cell 15:167-70. 2009
    ..We discuss here how VEGF inhibitors can induce such divergent effects on primary tumor growth and metastasis...
  73. ncbi request reprint Manipulating angiogenesis in medicine
    Peter Carmeliet
    Center for Transgene Technology and Gene Therapy, Flanders Interuniversitary Institute for Biotechnology, KU Leuven, Campus Gasthuisberg, Herestraat 49, B 3000 Leuven, Belgium
    J Intern Med 255:538-61. 2004
    ..That such therapeutic strategies might change the face of medicine is witnessed by initial evidence of success in the clinic...
  74. ncbi request reprint VEGF at the neurovascular interface: therapeutic implications for motor neuron disease
    Diether Lambrechts
    Center for Transgene Technology and Gene Therapy, Flanders Interuniversitary Institute for Biotechnology, KULeuven, Campus Gasthuisberg, Herestraat 49, B 3000 Leuven, Belgium
    Biochim Biophys Acta 1762:1109-21. 2006
    ....
  75. doi request reprint VEGF pathway genetic variants as biomarkers of treatment outcome with bevacizumab: an analysis of data from the AViTA and AVOREN randomised trials
    Diether Lambrechts
    Laboratory of Translational Genetics, Vesalius Research Center, VIB and KULeuven, Leuven, Belgium
    Lancet Oncol 13:724-33. 2012
    ..We assessed whether genetic variants in the VEGF pathway could act as biomarkers for bevacizumab treatment outcome...
  76. doi request reprint Oxygen sensors at the crossroad of metabolism
    Julian Aragones
    Vesalius Research Center, K U Leuven, Leuven, B 3000, Belgium
    Cell Metab 9:11-22. 2009
    ..These insights may offer novel opportunities for the treatment of ischemic diseases...
  77. doi request reprint The neurovascular link in health and disease: an update
    Inmaculada Segura
    Vesalius Research Center VRC, VIB, Leuven, 3000, Belgium
    Trends Mol Med 15:439-51. 2009
    ..Finally, we briefly discuss some therapeutic implications of the neurovascular link for designing strategies to treat these diseases...
  78. doi request reprint Oxygen sensing: a common crossroad in cancer and neurodegeneration
    Annelies Quaegebeur
    Vesalius Research Center VRC, VIB, K U Leuven, Campus Gasthuisberg, Herestraat 49, 3000, Leuven, Belgium
    Curr Top Microbiol Immunol 345:71-103. 2010
    ..We will focus on how PHD/HIF signaling is pathogenetically implicated in metabolic and vessel alterations in these diseases and how manipulation of this pathway might offer novel treatment opportunities...
  79. doi request reprint The neurovascular link in health and disease: molecular mechanisms and therapeutic implications
    Annelies Quaegebeur
    The laboratory of Angiogenesis and Neurovascular link Vesalius Research Center, K U Leuven, Leuven, B 3000, Belgium
    Neuron 71:406-24. 2011
    ..Moreover, neurovascular strategies offer novel therapeutic opportunities for neurodegenerative disorders...
  80. doi request reprint Antiangiogenic therapy, hypoxia, and metastasis: risky liaisons, or not?
    Katrien De Bock
    Laboratory of Angiogenesis and Neurovascular Link, Vesalius Research Center, VIB, KU Leuven, Campus Gasthuisberg, Herestraat 49, 3000 Leuven, Belgium
    Nat Rev Clin Oncol 8:393-404. 2011
    ..In this article, we will discuss the emerging link between hypoxia signaling and the various steps of metastasis...
  81. doi request reprint Notch3 Arg170Cys knock-in mice display pathologic and clinical features of the neurovascular disorder cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy
    Goedele Wallays
    Vesalius Research Center, Flanders Institute for Biotechnology VIB, Leuven, Belgium
    Arterioscler Thromb Vasc Biol 31:2881-8. 2011
    ..Elucidation of its pathobiology is still incomplete and remains a challenge, in part because the available preclinical mouse models to date do not reproduce the full spectrum of CADASIL pathology and clinical disease...
  82. doi request reprint Metabolism and therapeutic angiogenesis
    Peter Carmeliet
    Vesalius Research Center, VIB KU Leuven, Leuven, Belgium
    N Engl J Med 358:2511-2. 2008
  83. ncbi request reprint Ttrap is an essential modulator of Smad3-dependent Nodal signaling during zebrafish gastrulation and left-right axis determination
    Camila V Esguerra
    Center for Transgene Technology and Gene Therapy, VIB, Herestraat 49, B 3000 Leuven, Belgium
    Development 134:4381-93. 2007
    ....
  84. doi request reprint Vessel abnormalization: another hallmark of cancer? Molecular mechanisms and therapeutic implications
    Katrien De Bock
    Vesalius Research Center, K U Leuven, Leuven, Belgium
    Curr Opin Genet Dev 21:73-9. 2011
    ..Here, we overview key novel molecular players that induce vessel normalization...
  85. doi request reprint "Antimyeloangiogenic" therapy for cancer by inhibiting PlGF
    Sonja Loges
    Vesalius Research Center VRC, VIB, Katholieke Universiteit Leuven, Leuven, Belgium
    Clin Cancer Res 15:3648-53. 2009
    ..Because of these promising results, a humanized alphaPlGF antibody (TB403) is currently evaluated in different phase I clinical trials in cancer patients...
  86. doi request reprint Mechanisms of vessel branching: filopodia on endothelial tip cells lead the way
    Frederik De Smet
    Vesalius Research Center, VIB, K U Leuven, Belgium
    Arterioscler Thromb Vasc Biol 29:639-49. 2009
    ..Here, we will discuss the molecular candidates that participate in the decision of endothelial cells to adapt these distinct fates and highlight the emerging insights on how these cells send out filopodia while navigating...
  87. ncbi request reprint Angiogenesis in life, disease and medicine
    Peter Carmeliet
    Center of Transgene Technology and Gene Therapy, University of Leuven, Flanders Interuniversity Institute for Biotechnology VIB, B 3000 Leuven, Belgium
    Nature 438:932-6. 2005
    ..Angiogenesis research will probably change the face of medicine in the next decades, with more than 500 million people worldwide predicted to benefit from pro- or anti-angiogenesis treatments...
  88. doi request reprint Genetics, epigenetics and pharmaco-(epi)genomics in angiogenesis
    Ian Buysschaert
    Vesalius Research Center, K U Leuven, Leuven, Belgium
    J Cell Mol Med 12:2533-51. 2008
    ..Importantly, these genetic insights might also be of important clinical relevance for the use of anti-angiogenic strategies in cancer or macular degeneration...
  89. pmc The diversity of endothelial cells: a challenge for therapeutic angiogenesis
    Edward M Conway
    Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, University of Leuven Gasthuisberg O and N, Herestraat 49, 3000 Leuven, Belgium
    Genome Biol 5:207. 2004
    ..Characterization of endothelial-cell diversity will facilitate the development of novel, highly specific and safe therapies for many diseases...
  90. pmc Carbohydrate metabolism is perturbed in peroxisome-deficient hepatocytes due to mitochondrial dysfunction, AMP-activated protein kinase (AMPK) activation, and peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α) suppression
    Annelies Peeters
    Laboratory of Cell Metabolism, Department of Pharmaceutical Sciences, University of Leuven, B 3000 Leuven, Belgium
    J Biol Chem 286:42162-79. 2011
    ..Because this is primarily due to impaired mitochondrial ATP production, these L-Pex5-deficient livers can also be considered as a model for secondary mitochondrial hepatopathies...
  91. ncbi request reprint Heterogeneity in motoneuron disease
    Diether Lambrechts
    The Center for Transgene Technology and Gene Therapy, K U Leuven, B 3000, Leuven, Belgium
    Trends Neurosci 30:536-44. 2007
    ....
  92. ncbi request reprint Gene prioritization through genomic data fusion
    Stein Aerts
    Laboratory of Neurogenetics, Department of Human Genetics, Flanders Interuniversity Institute for Biotechnology VIB, University of Leuven, Herestraat 49, bus 602, 3000 Leuven, Belgium
    Nat Biotechnol 24:537-44. 2006
    ..The approach described here offers an alternative integrative method for gene discovery...
  93. ncbi request reprint Zebrafish and Xenopus tadpoles: small animal models to study angiogenesis and lymphangiogenesis
    Annelii Ny
    Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, KULeuven, Campus Gasthuisberg, Herestraat 49, B 3000 Leuven, Belgium
    Exp Cell Res 312:684-93. 2006
    ..The advantages of these two models will be discussed in the present review...
  94. pmc Plasmin therapy enhances mobilization of HPCs after G-CSF
    Marc Tjwa
    Vesalius Research Center, Leuven, Belgium
    Blood 112:4048-50. 2008
    ..Moreover, thrombolytic agents, such as tenecteplase and microplasmin, enhance HPC mobilization in mice and humans. Taken together, these findings identify a novel role for plasmin in augmenting HPC mobilization in response to G-CSF...
  95. pmc A Sertoli cell-selective knockout of the androgen receptor causes spermatogenic arrest in meiosis
    Karel De Gendt
    Laboratory for Experimental Medicine and Endocrinology, Department of Developmental Biology, Flanders Interuniversity Institute for Biotechnology, Catholic University of Leuven, B 3000 Leuven, Belgium
    Proc Natl Acad Sci U S A 101:1327-32. 2004
    ..It is concluded that cell-autonomous action of the AR in SC is an absolute requirement for androgen maintenance of complete spermatogenesis, and that spermatocyte/spermatid development/survival critically depends on androgens...
  96. ncbi request reprint Angiogenesis in health and disease
    Peter Carmeliet
    Center for Transgene Technology and Gene Therapy, Flanders Interuniversitary Institute for Biotechnology, KULeuven, Campus Gasthuisberg, Herestraat 49, B 3000, Leuven, Belgium
    Nat Med 9:653-60. 2003
    ..Molecular insights into these processes are being generated at a rapidly increasing pace, offering new therapeutic opportunities that are currently being evaluated...