VEGF ligands and receptors: implications in neurodevelopment and neurodegenerationPeter Carmeliet
Laboratory of Angiogenesis and Neurovascular Link, Vesalius Research Center, K U Leuven, 3000, Leuven, Belgium
Cell Mol Life Sci 70:1763-78. 2013
..We also discuss recent findings demonstrating that other VEGF ligands influence processes such as neurogenesis and dendrite arborization and participate in neurodegeneration...
- Treating diabetes by blocking a vascular growth factor
Peter Carmeliet
Department of Oncology, University of Leuven, Leuven, Belgium, Laboratory of Angiogenesis and Neurovascular Link, Vesalius Research Center, B 3000, Leuven, Belgium VIB, Leuven, Belgium, Laboratory of Angiogenesis and Neurovascular Link, Vesalius Research Center, B 3000, Leuven, Belgium Electronic address
Cell Metab 16:553-5. 2012
..2012) report that targeting the vascular endothelial growth factor (VEGF)-B restores insulin sensitivity and glucose tolerance by inhibiting endothelial-to-tissue lipid transport, opening promising avenues for diabetes therapy...
Prevention of elastase-induced emphysema in placenta growth factor knock-out miceShih Lung Cheng
Department of Internal Medicine, Far Eastern Memorial Hospital, Taiwan
Respir Res 10:115. 2009
..This study hypothesizes that blocking PlGF prevents the development of emphysema...
- Principles and mechanisms of vessel normalization for cancer and other angiogenic diseases
Peter Carmeliet
Vesalius Research Center, VIB, K U Leuven, Campus Gasthuisberg, Herestraat 49, B 3000 Leuven, Belgium
Nat Rev Drug Discov 10:417-27. 2011
..Here, we discuss the mechanisms, benefits, limitations and possible clinical translation of vessel normalization for cancer and other angiogenic disorders...
- Molecular mechanisms and clinical applications of angiogenesis
Peter Carmeliet
Laboratory of Angiogenesis and Neurovascular Link, Vesalius Research Center, VIB, Leuven B 3000, Belgium
Nature 473:298-307. 2011
..Recent preclinical and clinical studies have shown new molecular targets and principles, which may provide avenues for improving the therapeutic benefit from anti-angiogenic strategies...
- Reevaluation of the role of VEGF-B suggests a restricted role in the revascularization of the ischemic myocardium
Xuri Li
Vesalius Research Center, VIB, 3000 Leuven, Belgium
Arterioscler Thromb Vasc Biol 28:1614-20. 2008
..The endogenous role of the VEGF family member vascular endothelial growth factor-B (VEGF-B) in pathological angiogenesis remains unclear...
- Role of delta-like-4/Notch in the formation and wiring of the lymphatic network in zebrafish
Ilse Geudens
Vesalius Research Center, VIB, Leuven, Belgium
Arterioscler Thromb Vasc Biol 30:1695-702. 2010
..To study whether Notch signaling, which regulates cell fate decisions and vessel morphogenesis, controls lymphatic development...
- Increased skeletal VEGF enhances beta-catenin activity and results in excessively ossified bones
Christa Maes
Laboratory of Experimental Medicine and Endocrinology, Department of Experimental Medicine, KU Leuven, Leuven, Belgium
EMBO J 29:424-41. 2010
..Moreover, the finding that VEGF can modulate beta-catenin activity may have widespread physiological and clinical ramifications...
Role of vascular endothelial growth factor and placental growth factor in basal adhesion formation and in carbon dioxide pneumoperitoneum-enhanced adhesion formation after laparoscopic surgery in transgenic miceCarlos Roger Molinas
Center for Surgical Technologies, Katholieke Universiteit Leuven, Leuven, Belgium
Fertil Steril 80:803-11. 2003
..To evaluate the role of vascular endothelial growth factor (VEGF) and placental growth factor (PlGF) in adhesion formation after laparoscopic surgery...
- Role of synectin in lymphatic development in zebrafish and frogs
Karlien Hermans
Vesalius Research Center, Vlaams Iustituut voor Biotechnologie, Katholieke Universiteit Leuven, Campus Gasthuisberg, Herestraat 49, Leuven, Belgium
Blood 116:3356-66. 2010
..These findings reveal a novel role for synectin in lymphatic development...
- Anti-PlGF inhibits growth of VEGF(R)-inhibitor-resistant tumors without affecting healthy vessels
Christian Fischer
Department for Transgene Technology and Gene Therapy, VIB, 3000, Leuven, Belgium
Cell 131:463-75. 2007
..The efficacy and safety of alphaPlGF, its pleiotropic and complementary mechanism to VEGF(R)Is, and the negligible induction of an angiogenic rescue program suggest that alphaPlGF may constitute a novel approach for cancer treatment...
- Malignant cells fuel tumor growth by educating infiltrating leukocytes to produce the mitogen Gas6
Sonja Loges
Vesalius Research Center VRC, Vlaams Instituut voor Biotechnologie VIB, Leuven, Belgium
Blood 115:2264-73. 2010
..Hence, inhibition of Gas6 might offer novel opportunities for the treatment of cancer...
- Matrix-binding vascular endothelial growth factor (VEGF) isoforms guide granule cell migration in the cerebellum via VEGF receptor Flk1
Carmen Ruiz de Almodovar
Vesalius Research Center, Vlaams Instituut voor Biotechnologie, Vesalius Research Center, Katholieke Universiteit Leuven, Belgium
J Neurosci 30:15052-66. 2010
..These findings identify a previously unknown role for VEGF in neuronal migration...
- Anti-placental growth factor reduces bone metastasis by blocking tumor cell engraftment and osteoclast differentiation
Lieve Coenegrachts
Laboratory of Experimental Medicine and Endocrinology, Vesalius Research Center, KU Leuven, Belgium
Cancer Res 70:6537-47. 2010
..These findings identify novel properties of PlGF and suggest that alphaPlGF might offer opportunities for adjuvant therapy of bone metastasis...
- Transcription factor COUP-TFII is indispensable for venous and lymphatic development in zebrafish and Xenopus laevis
Xabier L Aranguren
Center for Molecular and Vascular Biology, Katholieke Universiteit Leuven, Campus Gasthuisberg, Onderwijs and Navorsing 1, Herestraat 49, B 3000 Leuven, Belgium
Biochem Biophys Res Commun 410:121-6. 2011
..Therefore, the role of NR2F2 in EC fate determination is evolutionary conserved...
- Heterozygous deficiency of PHD2 restores tumor oxygenation and inhibits metastasis via endothelial normalization
Massimiliano Mazzone
Vesalius Research Center, VIB Vlaams Instituut voor Biotechnologie, Leuven, Belgium
Cell 136:839-51. 2009
..Inhibition of PHD2 may offer alternative therapeutic opportunities for anticancer therapy...
- Role of PlGF in the intra- and intermolecular cross talk between the VEGF receptors Flt1 and Flk1
Monica Autiero
The Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, KULeuven, Leuven, B 3000, Belgium
Nat Med 9:936-43. 2003
....
- Novel role for vascular endothelial growth factor (VEGF) receptor-1 and its ligand VEGF-B in motor neuron degeneration
Koen Poesen
Vesalius Research Center, Katholieke Universiteit Leuven, Leuven B 3000, Belgium
J Neurosci 28:10451-9. 2008
..The neuroprotective activity of VEGF-B, in combination with its negligible angiogenic/permeability activity, offers attractive opportunities for the treatment of neurodegenerative diseases...
- Revascularization of ischemic tissues by PDGF-CC via effects on endothelial cells and their progenitors
Xuri Li
The Center for Transgene Technology and Gene Therapy, Flanders Interuniversitary Institute for Biotechnology (VIB, University of Leuven, Leuven, Belgium
J Clin Invest 115:118-27. 2005
..Moreover, delivery of PDGF-CC enhanced postischemic revascularization of the heart and limb. Modulating the activity of PDGF-CC may provide novel opportunities for treating ischemic diseases...
- Fibrinolysis-independent role of plasmin and its activators in the haematopoietic recovery after myeloablation
Marc Tjwa
Vesalius Research Center, VIB, Leuven, Belgium
J Cell Mol Med 13:4587-95. 2009
..These findings provide novel insights in how plasmin regulates haematopoietic recovery upon cytotoxic myeloablation...
- Impaired autonomic regulation of resistance arteries in mice with low vascular endothelial growth factor or upon vascular endothelial growth factor trap delivery
Erik Storkebaum
Vesalius Research Center, KU Leuven and VIB, Leuven, Belgium
Circulation 122:273-81. 2010
..Control of peripheral resistance arteries by autonomic nerves is essential for the regulation of blood flow. The signals responsible for the maintenance of vascular neuroeffector mechanisms in the adult, however, remain largely unknown...
- Engineering vascularized bone: osteogenic and proangiogenic potential of murine periosteal cells
Nick van Gastel
Laboratory of Clinical and Experimental Endocrinology, Division of Skeletal Tissue Engineering, KU Leuven, Leuven, Belgium
Stem Cells 30:2460-71. 2012
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- Vitamin D receptor in chondrocytes promotes osteoclastogenesis and regulates FGF23 production in osteoblasts
Ritsuko Masuyama
Laboratory of Experimental Medicine and Endocrinology, Katholieke Universiteit Leuven, Leuven, Belgium
J Clin Invest 116:3150-9. 2006
..Taken together, our findings provide evidence that VDR signaling in chondrocytes is required for timely osteoclast formation during bone development and for the endocrine action of bone in phosphate homeostasis...
- Short-term delivery of anti-PlGF antibody delays progression of atherosclerotic plaques to vulnerable lesions
Carmen Roncal
Vesalius Research Center, VIB, KULeuven, Campus Gasthuisberg, Herestraat 49, Box 912, 3000 Leuven, Belgium
Cardiovasc Res 86:29-36. 2010
..Previous gene-inactivation studies revealed that the loss of PlGF delays atherosclerotic lesion development and inhibits macrophage infiltration, but the activity of an anti-PlGF antibody (alphaPlGF mAb) has not been evaluated yet...
- VEGF-D deficiency in mice does not affect embryonic or postnatal lymphangiogenesis but reduces lymphatic metastasis
Marta Koch
Vesalius Research Centre, VIB, B 3000 Leuven, Belgium
J Pathol 219:356-64. 2009
....
- VEGF: once regarded as a specific angiogenic factor, now implicated in neuroprotection
Erik Storkebaum
Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, University of Leuven, Belgium
Bioessays 26:943-54. 2004
..These findings have raised growing interest in assessing the therapeutic potential of VEGF for neurodegenerative disorders...
- Soluble VEGF isoforms are essential for establishing epiphyseal vascularization and regulating chondrocyte development and survival
Christa Maes
Laboratory of Experimental Medicine and Endocrinology, Katholieke Universiteit Leuven, Leuven, Belgium
J Clin Invest 113:188-99. 2004
..These findings indicate that the insoluble VEGF(188) isoform is insufficient for establishing epiphyseal vascularization and regulating cartilage development during endochondral bone formation...
- Gas6 promotes inflammation by enhancing interactions between endothelial cells, platelets, and leukocytes
Marc Tjwa
Department of Transgene Technology and Gene Therapy, Flanders Institute of Biotechnology VIB, Leuven, Belgium
Blood 111:4096-105. 2008
..Thus, Gas6 amplifies EC activation, thereby playing a key role in enhancing the interactions between ECs, platelets, and leukocytes during inflammation...
- Treatment of motoneuron degeneration by intracerebroventricular delivery of VEGF in a rat model of ALS
Erik Storkebaum
The Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology VIB, KU Leuven, Leuven B 3000, Belgium
Nat Neurosci 8:85-92. 2005
..On i.c.v. delivery, Vegf is anterogradely transported and preserves neuromuscular junctions in SOD1(G93A) rats. Our findings in preclinical rodent models of ALS may have implications for treatment of neurodegenerative disease in general...
- Cardia bifida, defective heart development and abnormal neural crest migration in embryos lacking hypoxia-inducible factor-1alpha
Veerle Compernolle
Flanders Interuniversitary Institute for Biotechnology, KU Leuven, Campus Gasthuisberg, Herestraat 49, B 3000 Leuven, Belgium
Cardiovasc Res 60:569-79. 2003
..We attempted to further characterize the underlying mechanisms resulting in abnormal cardiogenesis and defective angiogenesis in mice deficient for HIF-1alpha (HIF-1alpha(-/-))...
- From vessel sprouting to normalization: role of the prolyl hydroxylase domain protein/hypoxia-inducible factor oxygen-sensing machinery
Cathy Coulon
Vesalius Research Center, Vlaams Instituut voor Biotechnologie, Katholieke Universiteit Leuven, Campus Gasthuisberg, Herestraat 49, B 3000 Leuven, Belgium
Arterioscler Thromb Vasc Biol 30:2331-6. 2010
..Given the essential role of hypoxia as the driving force for initiating angiogenesis, it is not surprising that the hypoxia-sensing machinery controls key steps in physiological and pathological angiogenesis...
- Gene-targeting of Phd2 improves tumor response to chemotherapy and prevents side-toxicity
Rodrigo Leite De Oliveira
Lab of Molecular Oncology and Angiogenesis, Vesalius Research Center, VIB, 3000 Leuven, Belgium
Cancer Cell 22:263-77. 2012
..Altogether, our study discloses alternative strategies for chemotherapy optimization...
- Role of hypoxia inducible factors 1alpha and 2alpha in basal adhesion formation and in carbon dioxide pneumoperitoneum-enhanced adhesion formation after laparoscopic surgery in transgenic mice
Carlos Roger Molinas
Center for Surgical Technologies, Katholieke Universiteit Leuven, Leuven, Belgium
Fertil Steril 80:795-802. 2003
..To evaluate the role of hypoxia inducible factors (HIFs) 1alpha and 2alpha in adhesion formation after laparoscopic surgery...
- Further pharmacological and genetic evidence for the efficacy of PlGF inhibition in cancer and eye disease
Sara Van de Veire
Vesalius Research Center, KU Leuven, Leuven B 3000, Belgium
Cell 141:178-90. 2010
..Further, we show that PlGF blockage inhibits vessel abnormalization rather than density in certain tumors while enhancing VEGF-targeted inhibition in ocular disease. Our findings warrant further testing of anti-PlGF therapies...
- Membrane-anchored uPAR regulates the proliferation, marrow pool size, engraftment, and mobilization of mouse hematopoietic stem/progenitor cells
Marc Tjwa
VIB Vesalius Research Center, Katholieke Universiteit Leuven, Leuven, Belgium
J Clin Invest 119:1008-18. 2009
..These findings identify MuPAR and plasmin as regulators of the proliferation, marrow pool size, homing, engraftment, and mobilization of HSPCs and possibly also of HSCs...
- Role of VEGF-D and VEGFR-3 in developmental lymphangiogenesis, a chemicogenetic study in Xenopus tadpoles
Annelii Ny
Vesalius Research Center, VIB KU Leuven, Leuven, Belgium
Blood 112:1740-9. 2008
..These findings document a critical role of VEGFR-3 in embryonic lymphatic development and function, and reveal a previously unrecognized modifier role of VEGF-D in the regulation of embryonic lymphangiogenesis in frog embryos...
- Progranulin functions as a neurotrophic factor to regulate neurite outgrowth and enhance neuronal survival
Philip Van Damme
Laboratory of Neurobiology, Flanders Interuniversity Institute for Biotechnology, Katholieke Universiteit Leuven, Campus Gasthuisberg, 3000 Leuven, Belgium
J Cell Biol 181:37-41. 2008
..These results demonstrate that PGRN/GRN is a neurotrophic factor with activities that may be involved in the development of the nervous system and in neurodegeneration...
- VEGF mediates commissural axon chemoattraction through its receptor Flk1
Carmen Ruiz de Almodovar
VIB, Laboratory for Angiogenesis and the Neurovascular link, Vesalius Research Center, KULeuven, Leuven, Belgium
Neuron 70:966-78. 2011
..Similar to Shh and Netrin-1, VEGF-mediated commissural axon guidance requires the activity of Src family kinases. Our results identify VEGF and Flk1 as a novel ligand/receptor pair controlling commissural axon guidance...
- Placental growth factor mediates mesenchymal cell development, cartilage turnover, and bone remodeling during fracture repair
Christa Maes
Laboratory of Experimental Medicine and Endocrinology, Katholieke Universiteit Leuven, Leuven, Belgium
J Clin Invest 116:1230-42. 2006
..Therefore PlGF may potentially offer therapeutic advantages for fracture repair...
- A novel role for vascular endothelial growth factor as an autocrine survival factor for embryonic stem cells during hypoxia
Koen Brusselmans
Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology (VIB, KULeuven, Leuven, B-3000, Belgium
J Biol Chem 280:3493-9. 2005
..Thus, VEGF plays a critical role in survival of ES cells during prolonged hypoxia...
- Impaired adipose tissue development in mice with inactivation of placental growth factor function
H Roger Lijnen
Center for Molecular and Vascular Biology, KU Leuven, Campus Gasthuisberg, O and N 1, Box 911, Herestraat 49, B 3000 Leuven, Belgium
Diabetes 55:2698-704. 2006
..Thus, in murine models of diet-induced obesity, inactivation of PlGF impairs adipose tissue development, at least in part as a result of reduced angiogenesis...
- Astrocytes regulate GluR2 expression in motor neurons and their vulnerability to excitotoxicity
Philip Van Damme
Laboratory of Neurobiology, Flanders Interuniversity Institute for Biotechnology, University of Leuven, B 3000 Leuven, Belgium
Proc Natl Acad Sci U S A 104:14825-30. 2007
..These results reveal a mechanism through which astrocytes influence neuronal functioning in health and disease...
- VEGF is a modifier of amyotrophic lateral sclerosis in mice and humans and protects motoneurons against ischemic death
Diether Lambrechts
The Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology and Department of Neurology, University Hospital Gasthuisberg, KU Leuven, Leuven, B 3000, Belgium
Nat Genet 34:383-94. 2003
..These findings indicate that VEGF is a modifier of motoneuron degeneration in human ALS and unveil a therapeutic potential of Vegfa for stressed motoneurons in mice...
- Loss or inhibition of uPA or MMP-9 attenuates LV remodeling and dysfunction after acute pressure overload in mice
Stephane Heymans
Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute, Herestraat 49, B 3000 Leuven, Belgium
Am J Pathol 166:15-25. 2005
..Deficiency of MMP-9 had an intermediate effect. These findings suggest that the use of u-PA- or MMP-inhibitors might preserve cardiac pump function in LV pressure overloading...
- Food-restriction in obese dyslipidaemic diabetic mice partially restores basal contractility but not contractile reserve
An Van den Bergh
Department of Cardiovascular Diseases, Division of Experimental Cardiac Surgery, Katholieke Universiteit Leuven, Leuven, Belgium
Eur J Heart Fail 11:1118-25. 2009
..However, their effect on contractile dysfunction and impaired cardiac functional reserve is unknown...
- Loss of the cholesterol-binding protein prominin-1/CD133 causes disk dysmorphogenesis and photoreceptor degeneration
Serena Zacchigna
Vesalius Research Center, Vlaams Instituut voor Biotechnologie, Katholieke Universiteit Leuven, B 3000 Leuven, Belgium
J Neurosci 29:2297-308. 2009
..These findings shed novel insight on how Prom-1 regulates neural retinal development and phototransduction in vertebrates...
- Neuronal FLT1 receptor and its selective ligand VEGF-B protect against retrograde degeneration of sensory neurons
Joke Dhondt
Vesalius Research Center, Katholieke Universiteit Leuven, Leuven, Belgium
FASEB J 25:1461-73. 2011
..Overall, this indicates that VEGF-B, instead of acting as an angiogenic factor, exerts direct neuroprotective effects through FLT1. These findings also suggest a clinically relevant role for VEGF-B in preventing distal neuropathies...
- Regulation of angiogenesis by oxygen and metabolism
Peter Fraisl
Vesalius Research Center, Leuven, Belgium
Dev Cell 16:167-79. 2009
..We will highlight advances in how oxygen and metabolism regulate angiogenesis as well as how angiogenic factors in turn also regulate metabolism...
- Angiogenesis and lymphangiogenesis: highlights of the past year
Aernout Luttun
Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, Leuven, Belgium
Curr Opin Hematol 11:262-71. 2004
....
- VEGF and PlGF: two pleiotropic growth factors with distinct roles in development and homeostasis
Marc Tjwa
The Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, University of Leuven, 3000, Leuven, Belgium
Cell Tissue Res 314:5-14. 2003
..These new insights broaden the activity spectrum of these "angiogenic" growth factors, and may have therapeutic implications when using these growth factors for vascular and/or non-vascular purposes...
- Role of vascular endothelial growth factor receptor 1 in basal adhesion formation and in carbon dioxide pneumoperitoneum-enhanced adhesion formation after laparoscopic surgery in mice
Carlos Roger Molinas
Department of Obstetrics and Gynecology, University Hospital Gasthuisberg, Katholieke Universiteit Leuven, Leuven, Belgium
Fertil Steril 82:1149-53. 2004
..To evaluate the role of vascular endothelial growth factor receptor-1 (VEGFR-1) in adhesion formation after laparoscopic surgery...
- Genetic dissection of tumor angiogenesis: are PlGF and VEGFR-1 novel anti-cancer targets?
Aernout Luttun
The Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, KULeuven, Campus Gasthuisberg, Herestraat 49, B 3000 Leuven, Belgium
Biochim Biophys Acta 1654:79-94. 2004
..Together, these insights may bring anti-angiogenic drugs closer from bench to bedside...
- Similarities between angiogenesis and neural development: what small animal models can tell us
Serena Zacchigna
Department of Transgene Technology and Gene Therapy, VIB, Leuven, Belgium
Curr Top Dev Biol 80:1-55. 2008
..In the first part of this chapter, we will discuss the more commonly used animal models; in the second part, the striking similarities occurring during the development of the vascular and the neural systems will be revised...
- Role of Gas-6 in adipogenesis and nutritionally induced adipose tissue development in mice
Erik Maquoi
Center for Molecular and Vascular Biology, KU Leuven, Leuven, Belgium
Arterioscler Thromb Vasc Biol 25:1002-7. 2005
..A potential role of growth arrest-specific gene 6 (Gas-6) in energy storage in adipose tissue was investigated in murine models of obesity. Gas-6 is a ligand for the Axl, C-Mer, and Sky family of tyrosine kinase receptors...
- Peroxisome deficient aP2-Pex5 knockout mice display impaired white adipocyte and muscle function concomitant with reduced adrenergic tone
Katrin Martens
Laboratory of Cell Metabolism, Department of Pharmaceutical Sciences, KU Leuven, Leuven, Belgium
Mol Genet Metab 107:735-47. 2012
..We conclude that peroxisomal metabolism is necessary to maintain the adrenergic tone in mice, which in turn determines metabolic homeostasis...
- Systemic anti-vascular endothelial growth factor therapies induce a painful sensory neuropathy
An Verheyen
Laboratory for Translational Genetics, Department of Oncology, University of Leuven, B 3000 Leuven, Belgium
Brain 135:2629-41. 2012
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- Inhibition of oxygen sensors as a therapeutic strategy for ischaemic and inflammatory disease
Peter Fraisl
Vesalius Research Center, VIB, K U Leuven, Campus Gasthuisberg, Herestraat 49, B 3000 Leuven, Belgium
Nat Rev Drug Discov 8:139-52. 2009
..Advances in understanding of the role of these oxygen sensors in hypoxia tolerance, ischaemic preconditioning and inflammation are creating new opportunities for pharmacological interventions for ischaemic and inflammatory diseases...
- Endothelial oxygen sensors regulate tumor vessel abnormalization by instructing phalanx endothelial cells
Katrien De Bock
Vesalius Research Center, K U Leuven, Belgium
J Mol Med (Berl) 87:561-9. 2009
..This review discusses the role of PHD2 in the regulation of vessel (ab)normalization and the therapeutic potential of PHD2 inhibition for tumor invasiveness and metastasis...
- Thrombophilia in mice expressing a tissue factor variant lacking its transmembrane and cytosolic domain
Els Melis
The Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology VIB, KULeuven Campus Gasthuisberg, Leuven B 3000, Belgium
Biochem Biophys Res Commun 333:488-95. 2005
..This severe thrombotic phenotype associated with the presence of a non-anchored soluble TF variant underscores the recently recognized significance of circulating TF for thrombus formation and development...
- Loss of placental growth factor protects mice against vascular permeability in pathological conditions
Aernout Luttun
The Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, KU Leuven, Leuven B 3000, Belgium
Biochem Biophys Res Commun 295:428-34. 2002
..These findings suggest that inhibition of PlGF might be an attractive tool to reduce vascular leakage in various diseases...
- Overexpression of mutant superoxide dismutase 1 causes a motor axonopathy in the zebrafish
Robin Lemmens
Department of Neurology, University Hospital Gasthuisberg, K U Leuven, Belgium
Hum Mol Genet 16:2359-65. 2007
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- Effects of vascular endothelial growth factor (VEGF) on motor neuron degeneration
Ludo Van Den Bosch
Laboratory for Neurobiology, Department of Experimental Neurology, School of Medicine, University of Leuven, Leuven, Belgium
Neurobiol Dis 17:21-8. 2004
..Our results show that VEGF is a neurotrophic factor for motor neurons in vitro, and shortage of this neurotrophic factor may contribute to the motor neuron death observed in humans and animals with low VEGF expression levels...
- The nuclear scaffold protein NIPP1 is essential for early embryonic development and cell proliferation
Aleyde Van Eynde
Division of Biochemistry, Center for Transgene Technology and Gene Therapy, Flanders Interuniversity, Institute for Biotechnology, Leuven, Belgium
Mol Cell Biol 24:5863-74. 2004
..We conclude that NIPP1 is indispensable for early embryonic development and cell proliferation...
- Blood vessels and nerves: common signals, pathways and diseases
Peter Carmeliet
Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, Katholieke Universiteit Leuven, Campus Gasthuisberg, Herestraat 49, B 3000, Leuven, Belgium
Nat Rev Genet 4:710-20. 2003
..The realization that both systems use common genetic pathways should not only form links between vascular biology and neuroscience, but also promises to accelerate the discovery of new mechanistic insights and therapeutic opportunities...
- Role and therapeutic potential of VEGF in the nervous system
Carmen Ruiz de Almodovar
The Vesalius Research Center, KU Leuven and VIB, Leuven, Belgium
Physiol Rev 89:607-48. 2009
..We describe the molecular properties of VEGF and its receptors and review the current knowledge of its different functions and therapeutic potential in the nervous system during development, health, disease and in medicine...
- Silencing or fueling metastasis with VEGF inhibitors: antiangiogenesis revisited
Sonja Loges
Vesalius Research Center, VIB, B 3000 Leuven, Belgium
Cancer Cell 15:167-70. 2009
..We discuss here how VEGF inhibitors can induce such divergent effects on primary tumor growth and metastasis...
- Branching morphogenesis and antiangiogenesis candidates: tip cells lead the way
Peter Carmeliet
Vesalius Research Center, VIB, KULeuven, Campus Gasthuisberg, Herestraat 49, Leuven, Belgium
Nat Rev Clin Oncol 6:315-26. 2009
..This Review provides a conceptual framework in which molecular discoveries and principles are discussed in light of clinical opportunities to develop new antiangiogenic agents...
- Loss or inhibition of stromal-derived PlGF prolongs survival of mice with imatinib-resistant Bcr-Abl1(+) leukemia
Thomas Schmidt
Laboratory of Angiogenesis and Neurovascular Link, Vesalius Research Center VRC, VIB, K U Leuven, Belgium
Cancer Cell 19:740-53. 2011
..These results may warrant further investigation of the therapeutic potential of PlGF inhibition for (imatinib-resistant) CML...
- Manipulating angiogenesis in medicine
Peter Carmeliet
Center for Transgene Technology and Gene Therapy, Flanders Interuniversitary Institute for Biotechnology, KU Leuven, Campus Gasthuisberg, Herestraat 49, B 3000 Leuven, Belgium
J Intern Med 255:538-61. 2004
..That such therapeutic strategies might change the face of medicine is witnessed by initial evidence of success in the clinic...
- VEGF at the neurovascular interface: therapeutic implications for motor neuron disease
Diether Lambrechts
Center for Transgene Technology and Gene Therapy, Flanders Interuniversitary Institute for Biotechnology, KULeuven, Campus Gasthuisberg, Herestraat 49, B 3000 Leuven, Belgium
Biochim Biophys Acta 1762:1109-21. 2006
....
- VEGF pathway genetic variants as biomarkers of treatment outcome with bevacizumab: an analysis of data from the AViTA and AVOREN randomised trials
Diether Lambrechts
Laboratory of Translational Genetics, Vesalius Research Center, VIB and KULeuven, Leuven, Belgium
Lancet Oncol 13:724-33. 2012
..We assessed whether genetic variants in the VEGF pathway could act as biomarkers for bevacizumab treatment outcome...
- The neurovascular link in health and disease: molecular mechanisms and therapeutic implications
Annelies Quaegebeur
The laboratory of Angiogenesis and Neurovascular link Vesalius Research Center, K U Leuven, Leuven, B 3000, Belgium
Neuron 71:406-24. 2011
..Moreover, neurovascular strategies offer novel therapeutic opportunities for neurodegenerative disorders...
- Oxygen sensing: a common crossroad in cancer and neurodegeneration
Annelies Quaegebeur
Vesalius Research Center VRC, VIB, K U Leuven, Campus Gasthuisberg, Herestraat 49, 3000, Leuven, Belgium
Curr Top Microbiol Immunol 345:71-103. 2010
..We will focus on how PHD/HIF signaling is pathogenetically implicated in metabolic and vessel alterations in these diseases and how manipulation of this pathway might offer novel treatment opportunities...
- The neurovascular link in health and disease: an update
Inmaculada Segura
Vesalius Research Center VRC, VIB, Leuven, 3000, Belgium
Trends Mol Med 15:439-51. 2009
..Finally, we briefly discuss some therapeutic implications of the neurovascular link for designing strategies to treat these diseases...
- Oxygen sensors at the crossroad of metabolism
Julian Aragones
Vesalius Research Center, K U Leuven, Leuven, B 3000, Belgium
Cell Metab 9:11-22. 2009
..These insights may offer novel opportunities for the treatment of ischemic diseases...
- Antiangiogenic therapy, hypoxia, and metastasis: risky liaisons, or not?
Katrien De Bock
Laboratory of Angiogenesis and Neurovascular Link, Vesalius Research Center, VIB, KU Leuven, Campus Gasthuisberg, Herestraat 49, 3000 Leuven, Belgium
Nat Rev Clin Oncol 8:393-404. 2011
..In this article, we will discuss the emerging link between hypoxia signaling and the various steps of metastasis...
- Notch3 Arg170Cys knock-in mice display pathologic and clinical features of the neurovascular disorder cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy
Goedele Wallays
Vesalius Research Center, Flanders Institute for Biotechnology VIB, Leuven, Belgium
Arterioscler Thromb Vasc Biol 31:2881-8. 2011
..Elucidation of its pathobiology is still incomplete and remains a challenge, in part because the available preclinical mouse models to date do not reproduce the full spectrum of CADASIL pathology and clinical disease...
- Vessel abnormalization: another hallmark of cancer? Molecular mechanisms and therapeutic implications
Katrien De Bock
Vesalius Research Center, K U Leuven, Leuven, Belgium
Curr Opin Genet Dev 21:73-9. 2011
..Here, we overview key novel molecular players that induce vessel normalization...
- Mechanisms of vessel branching: filopodia on endothelial tip cells lead the way
Frederik De Smet
Vesalius Research Center, VIB, K U Leuven, Belgium
Arterioscler Thromb Vasc Biol 29:639-49. 2009
..Here, we will discuss the molecular candidates that participate in the decision of endothelial cells to adapt these distinct fates and highlight the emerging insights on how these cells send out filopodia while navigating...
- Metabolism and therapeutic angiogenesis
Peter Carmeliet
Vesalius Research Center, VIB-KU Leuven, Leuven, Belgium
N Engl J Med 358:2511-2. 2008
- Ttrap is an essential modulator of Smad3-dependent Nodal signaling during zebrafish gastrulation and left-right axis determination
Camila V Esguerra
Center for Transgene Technology and Gene Therapy, VIB, Herestraat 49, B 3000 Leuven, Belgium
Development 134:4381-93. 2007
....
- "Antimyeloangiogenic" therapy for cancer by inhibiting PlGF
Sonja Loges
Vesalius Research Center VRC, VIB, Katholieke Universiteit Leuven, Leuven, Belgium
Clin Cancer Res 15:3648-53. 2009
..Because of these promising results, a humanized alphaPlGF antibody (TB403) is currently evaluated in different phase I clinical trials in cancer patients...
- Genetics, epigenetics and pharmaco-(epi)genomics in angiogenesis
Ian Buysschaert
Vesalius Research Center, K U Leuven, Leuven, Belgium
J Cell Mol Med 12:2533-51. 2008
..Importantly, these genetic insights might also be of important clinical relevance for the use of anti-angiogenic strategies in cancer or macular degeneration...
- Angiogenesis in life, disease and medicine
Peter Carmeliet
Center of Transgene Technology and Gene Therapy, University of Leuven, Flanders Interuniversity Institute for Biotechnology VIB, B 3000 Leuven, Belgium
Nature 438:932-6. 2005
..Angiogenesis research will probably change the face of medicine in the next decades, with more than 500 million people worldwide predicted to benefit from pro- or anti-angiogenesis treatments...
- The diversity of endothelial cells: a challenge for therapeutic angiogenesis
Edward M Conway
Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, University of Leuven Gasthuisberg O and N, Herestraat 49, 3000 Leuven, Belgium
Genome Biol 5:207. 2004
..Characterization of endothelial-cell diversity will facilitate the development of novel, highly specific and safe therapies for many diseases...
- Carbohydrate metabolism is perturbed in peroxisome-deficient hepatocytes due to mitochondrial dysfunction, AMP-activated protein kinase (AMPK) activation, and peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α) suppression
Annelies Peeters
Laboratory of Cell Metabolism, Department of Pharmaceutical Sciences, University of Leuven, B 3000 Leuven, Belgium
J Biol Chem 286:42162-79. 2011
..Because this is primarily due to impaired mitochondrial ATP production, these L-Pex5-deficient livers can also be considered as a model for secondary mitochondrial hepatopathies...
- Gene prioritization through genomic data fusion
Stein Aerts
Laboratory of Neurogenetics, Department of Human Genetics, Flanders Interuniversity Institute for Biotechnology VIB, University of Leuven, Herestraat 49, bus 602, 3000 Leuven, Belgium
Nat Biotechnol 24:537-44. 2006
..The approach described here offers an alternative integrative method for gene discovery...
- Heterogeneity in motoneuron disease
Diether Lambrechts
The Center for Transgene Technology and Gene Therapy, K U Leuven, B 3000, Leuven, Belgium
Trends Neurosci 30:536-44. 2007
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- Plasmin therapy enhances mobilization of HPCs after G-CSF
Marc Tjwa
Vesalius Research Center, Leuven, Belgium
Blood 112:4048-50. 2008
..Moreover, thrombolytic agents, such as tenecteplase and microplasmin, enhance HPC mobilization in mice and humans. Taken together, these findings identify a novel role for plasmin in augmenting HPC mobilization in response to G-CSF...
- Zebrafish and Xenopus tadpoles: small animal models to study angiogenesis and lymphangiogenesis
Annelii Ny
Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, KULeuven, Campus Gasthuisberg, Herestraat 49, B 3000 Leuven, Belgium
Exp Cell Res 312:684-93. 2006
..The advantages of these two models will be discussed in the present review...
- A Sertoli cell-selective knockout of the androgen receptor causes spermatogenic arrest in meiosis
Karel De Gendt
Laboratory for Experimental Medicine and Endocrinology, Department of Developmental Biology, Flanders Interuniversity Institute for Biotechnology, Catholic University of Leuven, B 3000 Leuven, Belgium
Proc Natl Acad Sci U S A 101:1327-32. 2004
..It is concluded that cell-autonomous action of the AR in SC is an absolute requirement for androgen maintenance of complete spermatogenesis, and that spermatocyte/spermatid development/survival critically depends on androgens...
- Angiogenesis in health and disease
Peter Carmeliet
Center for Transgene Technology and Gene Therapy, Flanders Interuniversitary Institute for Biotechnology, KULeuven, Campus Gasthuisberg, Herestraat 49, B 3000, Leuven, Belgium
Nat Med 9:653-60. 2003
..Molecular insights into these processes are being generated at a rapidly increasing pace, offering new therapeutic opportunities that are currently being evaluated...
