Respiratory impairment and systemic inflammation in cedar asthmatics removed from exposureChris Carlsten
Respiratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada
PLoS ONE 8:e57166. 2013
..Our objective was to evaluate residual respiratory impairment and associated sputum and blood biomarkers in subjects with Western red cedar asthma after exposure cessation...
- Cotinine versus questionnaire: early-life environmental tobacco smoke exposure and incident asthma
Chris Carlsten
Department of Medicine, University of British Columbia, Vancouver, Canada
BMC Pediatr 12:187. 2012
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Atopic dermatitis in a high-risk cohort: natural history, associated allergic outcomes, and risk factorsChris Carlsten
Chan Yeung Centre for Occupational and Environmental Lung Disease Unit, Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada
Ann Allergy Asthma Immunol 110:24-8. 2013
..Atopic dermatitis (AD) is commonly associated with asthma and other atopic disorders in childhood...
- Air pollution, genetics, and allergy: an update
Chris Carlsten
Air Pollution Exposure Laboratory, Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada
Curr Opin Allergy Clin Immunol 12:455-60. 2012
..However, evidence regarding causal effects of exposure and development of allergic conditions specifically remains immature. We review the developments of the past 18 months regarding air pollution, genetics and epigenetics, and allergy...
- Association between endotoxin and mite allergen exposure with asthma and specific sensitization at age 7 in high-risk children
Chris Carlsten
Respiratory Division, Department of Medicine, University of British Columbia, Vancouver, BC, Canada
Pediatr Allergy Immunol 22:320-6. 2011
..In high-risk children at age 7, endotoxin levels were associated with decreased sensitization to dog, as well as with decreased asthma...
- Elevated cord blood IgE is associated with recurrent wheeze and atopy at 7 yrs in a high risk cohort
Alexander Ferguson
Division of Allergy, Department of Pediatrics, University of British Columbia, Vancouver, BC, Canada
Pediatr Allergy Immunol 20:710-3. 2009
..22; 95% CI 1.11, 4.41) and recurrent wheeze at 7 yrs (OR 2.51, 95% CI 1.09, 5.76) but not with other outcomes. CB-IgE may be a useful measure for identifying children at high risk of atopic diseases for the purpose of primary prevention...
- Airway hyperresponsiveness to methacholine in 7-year-old children: sensitivity and specificity for pediatric allergist-diagnosed asthma
Chris Carlsten
Department of Medicine, Chan Yeung Centre for Occupational and Environmental Respiratory Disease, University of British Columbia, Vancouver, BC
Pediatr Pulmonol 46:175-8. 2011
..The operating characteristics of PC(20) values used as cut-offs to define airway hyperresponsiveness, as it informs the diagnosis of asthma in children, are poorly understood. We examine data from a unique cohort to inform this concern...
- Indoor allergen exposure, sensitization, and development of asthma in a high-risk birth cohort
Chris Carlsten
Division of Respirology, Department of Medicine, University of British Columbia, Vancouver, BC, Canada
Pediatr Allergy Immunol 21:e740-6. 2010
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- Traffic-related air pollution and incident asthma in a high-risk birth cohort
Chris Carlsten
Department of Medicine, University of British Columbia, Vancouver, Canada
Occup Environ Med 68:291-5. 2011
..We aimed to evaluate the hypothesis that the risk of new onset asthma is positively associated with early exposure to traffic-related air pollution in a well-characterised high-risk birth cohort...
- From good intentions to proven interventions: effectiveness of actions to reduce the health impacts of air pollution
Luisa V Giles
School of Human Kinetics, University of British Columbia, Vancouver, British Columbia, Canada
Environ Health Perspect 119:29-36. 2011
..Associations between air pollution and a multitude of health effects are now well established. Given ubiquitous exposure to some level of air pollution, the attributable health burden can be high, particularly for susceptible populations...
- Modification by antioxidant supplementation of changes in human lung function associated with air pollutant exposure: a systematic review
Amir Y Tashakkor
The University of British Columbia, Vancouver, British Columbia, Canada
BMC Public Health 11:532. 2011
..This study systematically presents current data on the potential benefits of antioxidant supplementation on lung function outcomes associated with air pollutant exposures in intact humans...
- The Air Pollution Exposure Laboratory (APEL) for controlled human exposure to diesel exhaust and other inhalants: characterization and comparison to existing facilities
Nicholas Birger
University of British Columbia, Vancouver, BC, Canada
Inhal Toxicol 23:219-25. 2011
..The Air Pollution Exposure Laboratory (APEL) was designed for the controlled inhalation of human subjects to aged and diluted diesel exhaust (DE) to mimic "real-world" occupational and environmental conditions...
- Personalized medicine and tobacco-related health disparities: is there a role for genetics?
Chris Carlsten
University of British Columbia, Vancouver, Canada
Ann Fam Med 9:366-71. 2011
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- Respiratory health effects of ambient air pollution: an update
Francesco Sava
Air Pollution Exposure Laboratory, Vancouver Coastal Health Research Institute, University of British Columbia, Vancouver General Hospital VGH Research Pavilion, Canada
Clin Chest Med 33:759-69. 2012
..A better definition of vulnerable populations may bolster local or regional efforts to remediate AAP. Advances in genetic research tools have the potential to identify candidate genes that can guide further research...
- Airway hyperresponsiveness and quality of life in Western red cedar asthmatics removed from exposure
Jian Qing He
Department of Respiratory Medicine West China Hospital, West China Medical School, Sichuan University, Chengdu, China
PLoS ONE 7:e50774. 2012
..Consequently, health-related quality of life (HRQL) is often impaired. The objective of this study was to evaluate the relationship between two measures of AHR and HRQL scores in those with WRCA...
- Respiratory disease associated with solid biomass fuel exposure in rural women and children: systematic review and meta-analysis
June Y T Po
Department of Medicine, The University of British Columbia, Vancouver, British Columbia, Canada
Thorax 66:232-9. 2011
..Numerous studies with varying associations between domestic use of solid biomass fuels (wood, dung, crop residue, charcoal) and respiratory diseases have been reported...
