Carsten Carlberg

Summary

Affiliation: University of Eastern Finland
Location: Kuopio, Finland
URL: www.uef.fi/biolaaketiede/carlberg

Publications

  1. ncbi The first genome-wide view of vitamin D receptor locations and their mechanistic implications
    Carsten Carlberg
    Department of Biosciences, University of Eastern Finland, P O Box 1627, FIN 70211 Kuopio, Finland
    Anticancer Res 32:271-82. 2012
  2. ncbi The human peroxisome proliferator-activated receptor delta gene is a primary target of 1alpha,25-dihydroxyvitamin D3 and its nuclear receptor
    Thomas W Dunlop
    Department of Biochemistry, University of Kuopio, FIN 70211 Kuopio, Finland
    J Mol Biol 349:248-60. 2005
  3. ncbi Vitamin D and cancer: effects of 1,25(OH)2D3 and its analogs on growth control and tumorigenesis
    C M Hansen
    Department of Biochemistry, University of Kuopio, P O B 1627, FIN 70211 Kuopio, Finland
    Front Biosci 6:D820-48. 2001
  4. pmc Screening for PPAR Responsive Regulatory Modules in Cancer
    Merja Heinaniemi
    Life Sciences Research Unit, University of Luxembourg, 1511 Luxembourg, Luxembourg
    PPAR Res 2008:749073. 2008
  5. ncbi VDR-Alien: a novel, DNA-selective vitamin D(3) receptor-corepressor partnership
    P Polly
    Institut fur Physiologische Chemie I, Heinrich Heine Universitat, D 40001 Dusseldorf, Germany
    FASEB J 14:1455-63. 2000
  6. pmc The number of vitamin D receptor binding sites defines the different vitamin D responsiveness of the CYP24 gene in malignant and normal mammary cells
    Juha M Matilainen
    Department of Biosciences, University of Eastern Finland, FIN 70211 Kuopio, Finland
    J Biol Chem 285:24174-83. 2010
  7. ncbi Differential nuclear receptor signalling from DR4-type response elements
    Marcus Quack
    Institute for Physiological Chemistry I, Heinrich Heine University, D 40001 Dusseldorf, Germany
    J Cell Biochem 86:601-12. 2002
  8. ncbi Cross-repression, a functional consequence of the physical interaction of non-liganded nuclear receptors and POU domain transcription factors
    Manuel Macias Gonzalez
    Department of Biochemistry, University of Kuopio, FIN 70211 Kuopio, Finland
    J Biol Chem 277:18501-9. 2002
  9. ncbi Corepressor excess shifts the two-side chain vitamin D analog Gemini from an agonist to an inverse agonist of the vitamin D receptor
    Manuel Macias Gonzalez
    Department of Biochemistry, University of Kuopio, FIN 70211 Kuopio, Finland
    Mol Endocrinol 17:2028-38. 2003
  10. pmc Regulation of multiple insulin-like growth factor binding protein genes by 1alpha,25-dihydroxyvitamin D3
    Merja Matilainen
    Department of Biochemistry, University of Kuopio, P O Box 1627, IN 70211 Kuopio, Finland
    Nucleic Acids Res 33:5521-32. 2005

Detail Information

Publications140 found, 100 shown here

  1. ncbi The first genome-wide view of vitamin D receptor locations and their mechanistic implications
    Carsten Carlberg
    Department of Biosciences, University of Eastern Finland, P O Box 1627, FIN 70211 Kuopio, Finland
    Anticancer Res 32:271-82. 2012
    ..This review provides a detailed comparison of the insights obtained from both ChIP-Seq studies...
  2. ncbi The human peroxisome proliferator-activated receptor delta gene is a primary target of 1alpha,25-dihydroxyvitamin D3 and its nuclear receptor
    Thomas W Dunlop
    Department of Biochemistry, University of Kuopio, FIN 70211 Kuopio, Finland
    J Mol Biol 349:248-60. 2005
    ....
  3. ncbi Vitamin D and cancer: effects of 1,25(OH)2D3 and its analogs on growth control and tumorigenesis
    C M Hansen
    Department of Biochemistry, University of Kuopio, P O B 1627, FIN 70211 Kuopio, Finland
    Front Biosci 6:D820-48. 2001
    ..The present review will focus on the results obtained in these studies and describe some of the synthetic analogs, which have shown to be of particular interest in relation to cancer...
  4. pmc Screening for PPAR Responsive Regulatory Modules in Cancer
    Merja Heinaniemi
    Life Sciences Research Unit, University of Luxembourg, 1511 Luxembourg, Luxembourg
    PPAR Res 2008:749073. 2008
    ..Recent advances in genomic techniques combined with computational analysis of binding modules are discussed in the review with the example of our recent screen for PPREs on human chromosome 19...
  5. ncbi VDR-Alien: a novel, DNA-selective vitamin D(3) receptor-corepressor partnership
    P Polly
    Institut fur Physiologische Chemie I, Heinrich Heine Universitat, D 40001 Dusseldorf, Germany
    FASEB J 14:1455-63. 2000
    ..Taken together, association of the VDR with corepressor proteins provides a further level of transcriptional regulation, which is emerging as a complex network of protein-protein interaction-mediated control...
  6. pmc The number of vitamin D receptor binding sites defines the different vitamin D responsiveness of the CYP24 gene in malignant and normal mammary cells
    Juha M Matilainen
    Department of Biosciences, University of Eastern Finland, FIN 70211 Kuopio, Finland
    J Biol Chem 285:24174-83. 2010
    ..In conclusion, our data suggest that in comparison to normal cells, clearing of 1alpha,25(OH)(2)D(3) is enhanced in malignant cells due to differences in transcriptional regulation of CYP24 and metabolism of CYP24 mRNA...
  7. ncbi Differential nuclear receptor signalling from DR4-type response elements
    Marcus Quack
    Institute for Physiological Chemistry I, Heinrich Heine University, D 40001 Dusseldorf, Germany
    J Cell Biochem 86:601-12. 2002
    ....
  8. ncbi Cross-repression, a functional consequence of the physical interaction of non-liganded nuclear receptors and POU domain transcription factors
    Manuel Macias Gonzalez
    Department of Biochemistry, University of Kuopio, FIN 70211 Kuopio, Finland
    J Biol Chem 277:18501-9. 2002
    ..Taken together this study suggests that cross-repression should occur in all tissues in which POU domain factors and non-liganded NRs meet each other...
  9. ncbi Corepressor excess shifts the two-side chain vitamin D analog Gemini from an agonist to an inverse agonist of the vitamin D receptor
    Manuel Macias Gonzalez
    Department of Biochemistry, University of Kuopio, FIN 70211 Kuopio, Finland
    Mol Endocrinol 17:2028-38. 2003
    ..Taken together, Gemini is the first described (conditional) inverse agonist to an endocrine nuclear receptor and may function as a sensor for the cell-specific coactivator/CoR ratio...
  10. pmc Regulation of multiple insulin-like growth factor binding protein genes by 1alpha,25-dihydroxyvitamin D3
    Merja Matilainen
    Department of Biochemistry, University of Kuopio, P O Box 1627, IN 70211 Kuopio, Finland
    Nucleic Acids Res 33:5521-32. 2005
    ..In conclusion, IGFBP1, 3 and 5 are primary 1alpha,25(OH)2D3 target genes that in intact cells are each under the control of multiple VDREs...
  11. pmc Regulation of the human cyclin C gene via multiple vitamin D3-responsive regions in its promoter
    Lasse Sinkkonen
    Department of Biochemistry, University of Kuopio PO Box 1627, FIN 70211 Kuopio, Finland
    Nucleic Acids Res 33:2440-51. 2005
    ....
  12. pmc The impact of transcriptional cycling on gene regulation
    Carsten Carlberg
    University of Luxembourg, Luxembourg
    Transcription 1:13-6. 2010
    ....
  13. pmc Epigenetic control of a VDR-governed feed-forward loop that regulates p21(waf1/cip1) expression and function in non-malignant prostate cells
    James L Thorne
    Institute of Biomedical Research, University of Birmingham, Edgbaston B15 2TT, UK
    Nucleic Acids Res 39:2045-56. 2011
    ..Dissection of this feed-forward loop in a non-malignant prostate cell system illuminates mechanisms of sensitivity and therefore possible resistance in prostate and other VDR responsive cancers...
  14. pmc Dynamics of nuclear receptor target gene regulation
    Carsten Carlberg
    Life Sciences Research Unit, University of Luxembourg, Luxembourg
    Chromosoma 119:479-84. 2010
    ..In this review, we summarize recent findings on the dynamic regulation of nuclear receptor target genes in the chromatin context...
  15. doi Differential effects of 1α,25-dihydroxycholecalciferol on MCP-1 and adiponectin production in human white adipocytes
    Silvia Lorente-Cebrián
    Department of Medicine Huddinge, Lipid Laboratory, Karolinska Institutet, NVS, Karolinska University Hospital Huddinge, 141 86, Stockholm, Sweden
    Eur J Nutr 51:335-42. 2012
    ....
  16. pmc Profiling of promoter occupancy by PPARalpha in human hepatoma cells via ChIP-chip analysis
    David L M van der Meer
    Nutrition, Metabolism and Genomics Group, Division of Human Nutrition, Wageningen University, Bomenweg 2, NL 6703 HD Wageningen, The Netherlands
    Nucleic Acids Res 38:2839-50. 2010
    ..Overall, our analysis leads to important new insights into the mechanisms and impact of transcriptional regulation by PPARalpha in human liver and highlight the importance of cross-talk with other transcription factors...
  17. doi 25-Hydroxyvitamin D(3) is an agonistic vitamin D receptor ligand
    Yan Ru Lou
    Department of Anatomy, Medical School, University of Tampere, Tampere, FIN 33014, Finland
    J Steroid Biochem Mol Biol 118:162-70. 2010
    ..In conclusion, 25-hydroxyvitamin D(3) is an agonistic vitamin D receptor ligand with gene regulatory and anti-proliferative properties...
  18. pmc Regulation of the hyaluronan synthase 2 gene by convergence in cyclic AMP response element-binding protein and retinoid acid receptor signaling
    Katri M Makkonen
    Department of Bioscience, of Kuopio, FIN 70211 Kuopio, Finland
    J Biol Chem 284:18270-81. 2009
    ..In general, our findings suggest a convergence of CREB1 and RAR signaling, and demonstrate the individual character of each RE in terms of co-regulator use...
  19. ncbi Orphan nuclear receptor binding site in the human inducible nitric oxide synthase promoter mediates responsiveness to steroid and xenobiotic ligands
    Andrea Toell
    Institute for Physiological Chemistry I, Heinrich Heine University, Dusseldorf, Germany
    J Cell Biochem 85:72-82. 2002
    ..Since an iNOS-induced production of NO is known to influence inflammation and apoptosis, a CAR- and PXR-regulated iNOS activity may explain a modulatory effect of steroids and xenobiotics on these cellular processes...
  20. doi Molecular mechanism of allosteric communication in the human PPARalpha-RXRalpha heterodimer
    Tuomas Venäläinen
    Laboratory of Chemistry, Department of Biosciences, University of Kuopio, Kuopio FIN 70211, Finland
    Proteins 78:873-87. 2010
    ..Proteins 2010. (c) 2009 Wiley-Liss, Inc...
  21. ncbi The critical role of carboxy-terminal amino acids in ligand-dependent and -independent transactivation of the constitutive androstane receptor
    Teemu Andersin
    Department of Biochemistry, University of Kuopio, FIN 70211 Kuopio, Finland
    Mol Endocrinol 17:234-46. 2003
    ..We showed that this blockade is not due to an intramolecular disulfide bridge, but is probably caused by an interaction between C357 and Y336...
  22. ncbi Peroxisome proliferator-activated receptor delta is a specific sensor for teratogenic valproic acid derivatives
    A Lampen
    Zentrumsabteilung für Lebensmitteltoxikologie, Tierarztliche Hochschule Hannover, Bischofsholer Damm 15 115, D 30173, Hannover, Germany
    Eur J Pharmacol 431:25-33. 2001
    ..In conclusion, in contrast to PPAR-alpha and PPAR-gamma, PPAR-delta shows to be a specific sensor for teratogenic valproic acid-derivatives...
  23. ncbi Critical role of helix 12 of the vitamin D(3) receptor for the partial agonism of carboxylic ester antagonists
    Sami Väisänen
    Department of Biochemistry, University of Kuopio, Finland
    J Mol Biol 315:229-38. 2002
    ..In conclusion, partial agonism of a VDR antagonist is lower the more it disturbs helix 12 in taking the optimal position for coactivator interaction...
  24. pmc Single thyroid hormone receptor monomers are competent for co-activator-mediated transactivation
    M Quack
    Institute for Physiological Chemistry I, Heinrich-Heine-University, , Germany
    Biochem J 360:387-93. 2001
    ..Taken together, these results suggest that single T(3)R monomers are fully competent for ligand-induced transactivation and that their role in gene regulation by thyroid hormone might have been underestimated...
  25. ncbi Agonist-triggered modulation of the activated and silent state of the vitamin D(3) receptor by interaction with co-repressors and co-activators
    M Herdick
    Institut für Physiologische Chemie I and Biomedizinisches Forschungszentrum, Heinrich Heine Universitat, Dusseldorf, D 40001, Germany
    J Mol Biol 304:793-801. 2000
    ....
  26. ncbi Central role of VDR conformations for understanding selective actions of vitamin D(3) analogues
    C Carlberg
    Institut fur Physiologische Chemie I, Heinrich Heine Universitat, Postfach 10 10 07, D 40001, Dusseldorf, Germany
    Steroids 66:213-21. 2001
    ....
  27. ncbi Interaction of two novel 14-epivitamin D3 analogs with vitamin D3 receptor-retinoid X receptor heterodimers on vitamin D3 responsive elements
    L Verlinden
    Laboratorium voor Experimentele Geneeskunde en Endocrinologie, Katholieke Universiteit Leuven, Belgium
    J Bone Miner Res 16:625-38. 2001
    ..These data clearly indicate that superagonistic activity starts beyond the binding of the ligand-heterodimer (VDR-RXR) complex to VDRE and thus probably involves coactivator/corepressor molecules...
  28. ncbi Molecular evaluation of vitamin D3 receptor agonists designed for topical treatment of skin diseases
    Y Bury
    , , , Germany
    J Invest Dermatol 116:785-92. 2001
    ....
  29. ncbi Gene regulatory potential of 1alpha,25-dihydroxyvitamin D(3) analogues with two side chains
    Y Bury
    , , Postfach 10 10 07, , Germany
    J Cell Biochem Suppl . 2001
    ..Gemini was highlighted as an interesting drug candidate which could not be optimized through obvious chemical modifications in its A-ring. J. Cell. Biochem. Suppl. 36: 179-190, 2001...
  30. doi Primary effect of 1α,25(OH)₂D₃ on IL-10 expression in monocytes is short-term down-regulation
    Juha M Matilainen
    Department of Biosciences, University of Eastern Finland, FIN 70211 Kuopio, Finland
    Biochim Biophys Acta 1803:1276-86. 2010
    ..In conclusion, in LPS-treated THP-1 cells the primary effect of 1α,25(OH)₂D₃ on IL-10 expression is down-regulation, which is achieved via a cyclical recruitment of VDR to the promoter...
  31. ncbi Integration of the activation of the human hyaluronan synthase 2 gene promoter by common cofactors of the transcription factors retinoic acid receptor and nuclear factor kappaB
    Katri Saavalainen
    Department of Biochemistry, University of Kuopio, FIN 70211 Kuopio, Finland
    J Biol Chem 282:11530-9. 2007
    ..These findings partially explain the induction of HAS2 mRNA by all-trans-RA and TNF-alpha and provide an example how the action of different transcription factor families can use the same cofactors...
  32. ncbi The impact of chromatin organization of vitamin D target genes
    Carsten Carlberg
    Department of Biochemistry, University of Kuopio, FIN 70211 Kuopio, Finland
    Anticancer Res 26:2637-45. 2006
    ..These results will have an impact on the development of therapeutic regimes for diseases, such as cancer, that use 1alpha,25(OH)2D3 and its analogs...
  33. ncbi Analysis of the 5-lipoxygenase promoter and characterization of a vitamin D receptor binding site
    Bernd L Sorg
    Institute of Pharmaceutical Chemistry ZAFES, University of Frankfurt, Marie Curie Str 9, D 60439 Frankfurt, Germany
    Biochim Biophys Acta 1761:686-97. 2006
    ....
  34. pmc A Role for the PPARgamma in Cancer Therapy
    Moray J Campbell
    Department of Pharmacology and Therapeutics, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    PPAR Res 2008:314974. 2008
    ....
  35. ncbi Antagonist- and inverse agonist-driven interactions of the vitamin D receptor and the constitutive androstane receptor with corepressor protein
    Harri Lempiäinen
    Department of Biochemistry, University of Kuopio, P O Box 1627, FIN 70211 Kuopio, Finland
    Mol Endocrinol 19:2258-72. 2005
    ....
  36. pmc An aryl hydrocarbon receptor conformation acts as the functional core of nuclear dioxin signaling
    S Kronenberg
    Abteilung Immunologie des Medizinischen Instituts für Umwelthygiene and Institut für Physiologische Chemie I, Heinrich Heine Universitat Dusseldorf, Postfach 10 10 07, D 40001 Dusseldorf, Germany
    Nucleic Acids Res 28:2286-91. 2000
    ..In conclusion, the results of this study provide important information on the ligand sensitivity of AhR and AhR-Arnt heterodimer conformations...
  37. ncbi A structural basis for the species-specific antagonism of 26,23-lactones on vitamin D signaling
    MIKAEL PERAKYLA
    Department of Chemistry, University of Kuopio, FIN 70211 Kuopio, Finland
    Chem Biol 11:1147-56. 2004
    ..In contrast, N410 of the rat VDR stabilized, via backbone contacts, the interaction between helices 11 and 12. This results in TEI-9647 becoming a weak agonist in this organism...
  38. ncbi Agonist-dependent and agonist-independent transactivations of the human constitutive androstane receptor are modulated by specific amino acid pairs
    Christian Frank
    Department of Biochemistry, University of Kuopio, FIN 70211 Kuopio, Finland
    J Biol Chem 279:33558-66. 2004
    ..The constitutive activity of other members of the nuclear receptor superfamily could be explained by a homologous hydrophobic interaction between large, non-polar amino acids of helices 11 and 12...
  39. ncbi Clarification for The impact of transcriptional cycling on gene regulation
    Carsten Carlberg
    University of Luxembourg
    Transcription 2:50. 2011
    Clarification for The impact of transcriptional cycling on gene regulation : Carsten Carlberg: Volume 1, Issue : July/August 2010: Pages 13 - 16 : DOI: 10.4161/trns.1.1.11984.
  40. ncbi Lipid soluble vitamins in gene regulation
    C Carlberg
    Institut fur Physiologische Chemie I, Heinrich Heine Universitat, Dusseldorf, Germany
    Biofactors 10:91-7. 1999
    ..Moreover, for vitamin E modulatory effects on transcription factors, such as AP-1, have been described. This review will discuss briefly gene regulation by the four lipid soluble vitamins...
  41. ncbi Pineal gland hormone melatonin binds and activates an orphan of the nuclear receptor superfamily
    M Becker-Andre
    Glaxo Institute for Molecular Biology, Plan les Ouates, Switzerland
    J Biol Chem 269:28531-4. 1994
    ..A nuclear signaling pathway for melatonin may contribute to some of the diverse and profound effects of this hormone, for example, in the context of circadian rhythmicity...
  42. ncbi An integrated biological approach to nuclear receptor signaling in physiological control and disease
    Carsten Carlberg
    Department of Biochemistry, University of Kuopio, FIN 70211 Kuopio, Finland
    Crit Rev Eukaryot Gene Expr 16:1-22. 2006
    ..Furthermore, it is anticipated that systems biology methods will also help to identify the most critical genes, proteins, or metabolites in the NR network that will serve as biomarkers for the early detection of these diseases...
  43. ncbi Antagonistic action of a 25-carboxylic ester analogue of 1alpha, 25-dihydroxyvitamin D3 is mediated by a lack of ligand-induced vitamin D receptor interaction with coactivators
    M Herdick
    Institut für Physiologische Chemie I and Biomedizinisches Forschungszentrum, Heinrich Heine Universitat, D 40001 Dusseldorf, Germany
    J Biol Chem 275:16506-12. 2000
    ....
  44. pmc Electrophilic nitro-fatty acids activate NRF2 by a KEAP1 cysteine 151-independent mechanism
    Emilia Kansanen
    Department of Biotechnology and Molecular Medicine, A I Virtanen Institute for Molecular Sciences, University of Eastern Finland, FIN 70211 Kuopio, Finland
    J Biol Chem 286:14019-27. 2011
    ..OA-NO(2) can therefore be categorized as a Cys(151)-independent Nrf2 activator, which in turn can influence the pattern of gene expression and therapeutic actions of nitroalkenes...
  45. pmc Cyclical regulation of the insulin-like growth factor binding protein 3 gene in response to 1alpha,25-dihydroxyvitamin D3
    Marjo Malinen
    Department of Biosciences, University of Eastern Finland, Kuopio, Finland
    Nucleic Acids Res 39:502-12. 2011
    ..In conclusion, 1α,25(OH)(2)D(3) regulates IGFBP3 transcription through short-term cyclical association of VDR, HDAC4 and HDAC6 to both VDRE-containing chromatin regions...
  46. ncbi The nuclear receptor for melatonin represses 5-lipoxygenase gene expression in human B lymphocytes
    D Steinhilber
    Pharmazeutisches Institut, Universitat Tubingen, Germany
    J Biol Chem 270:7037-40. 1995
    ..This indicates that 5-lipoxygenase is the first natural RZR alpha responding gene. Furthermore, our results open up a new perspective in understanding the involvement of melatonin in inflammatory and immunological reactions...
  47. pmc Cellular content of UDP-N-acetylhexosamines controls hyaluronan synthase 2 expression and correlates with O-linked N-acetylglucosamine modification of transcription factors YY1 and SP1
    Tiina A Jokela
    Institute of Biomedicine, University of Eastern Finland, FIN 70211 Kuopio, Finland
    J Biol Chem 286:33632-40. 2011
    ....
  48. doi DICKKOPF-4 is induced by TCF/beta-catenin and upregulated in human colon cancer, promotes tumour cell invasion and angiogenesis and is repressed by 1alpha,25-dihydroxyvitamin D3
    N Pendas-Franco
    Instituto de Investigaciones Biomedicas Alberto Sols, Consejo Superior de Investigaciones Cientificas Universidad Autonoma de Madrid, Madrid, Spain
    Oncogene 27:4467-77. 2008
    ..In conclusion, DKK-4 is upregulated in colon cancer and is associated with the acquisition of malignant properties by neoplastic cells. DKK-4 downregulation is a novel effect of 1,25(OH)2D3 that may contribute to its anticancer action...
  49. pmc Distinct HDACs regulate the transcriptional response of human cyclin-dependent kinase inhibitor genes to Trichostatin A and 1alpha,25-dihydroxyvitamin D3
    Marjo Malinen
    Department of Biochemistry, University of Kuopio, FIN 70211 Kuopio, Finland
    Nucleic Acids Res 36:121-32. 2008
    ..This suggests that the attenuation of the response to TSA by NCoR1 or that to 1alpha,25(OH)2D3 by HDACs can be overcome by their combined application achieving maximal induction of anti-proliferative target genes...
  50. ncbi The vitamin D receptor
    Carsten Carlberg
    Life Sciences Research Unit, Universitè of Luxembourg, 162A, avenue de la Faiencerie, L 1511 Luxembourg, Luxembourg
    Dermatol Clin 25:515-23, viii. 2007
    ..More than 3000 synthetic analogs of 1alpha,25(OH)(2)D(3) are known. This review aims to provide an overview on vitamin D signaling from the skin perspective...
  51. pmc 1,25-dihydroxyvitamin D3 influences cellular homocysteine levels in murine preosteoblastic MC3T3-E1 cells by direct regulation of cystathionine β-synthase
    Carsten Kriebitzsch
    Laboratory for Experimental Medicine and Endocrinology LEGENDO, Catholic University of Leuven, Leuven, Belgium
    J Bone Miner Res 26:2991-3000. 2011
    ..In conclusion, this study showed that cbs is a primary 1,25(OH)(2) D(3) target gene which renders HCY metabolism responsive to 1,25(OH)(2) D(3)...
  52. ncbi Subcellular localisation of BAG-1 and its regulation of vitamin D receptor-mediated transactivation and involucrin expression in oral keratinocytes: implications for oral carcinogenesis
    San San Lee
    Department of Oral and Dental Science, University of Bristol, Lower Maudlin Street, Bristol BS1 2LY, UK
    Exp Cell Res 313:3222-38. 2007
    ..By contrast to the cytoplasmic BAG-1 isoforms, BAG-1L may act to suppress tumorigenesis...
  53. ncbi Functional characterization of vitamin D responding regions in the human 5-Lipoxygenase gene
    Sabine Seuter
    Institute of Pharmaceutical Chemistry, University of Frankfurt, D 60438 Frankfurt, Germany
    Biochim Biophys Acta 1771:864-72. 2007
    ..This indicates DNA looping of the TSS to even very distant gene regions. In summary, we suggest that the upregulation of the primary 1alpha,25(OH)(2)D(3) target 5-LO is mediated in vivo by a prominent VDRE in intron 4...
  54. pmc Variations in the ghrelin receptor gene associate with obesity and glucose metabolism in individuals with impaired glucose tolerance
    Ursula Mager
    Department of Clinical Nutrition, Food and Health Research Centre, University of Kuopio, Kuopio, Finland
    PLoS ONE 3:e2941. 2008
    ..Ghrelin may influence the development of obesity through its role in the control of energy balance, food intake, and regulation of body weight. The effects of ghrelin are mediated via the growth hormone secretagogue receptor (GHSR)...
  55. doi Coordinate induction of PPAR alpha and SREBP2 in multifunctional protein 2 deficient mice
    Katrin Martens
    Laboratory of Cell Metabolism, Department of Pharmaceutical Sciences, K U Leuven, Leuven, Belgium
    Biochim Biophys Acta 1781:694-702. 2008
    ..These data demonstrate a tight interrelationship between induction of PPAR alpha by endogenous ligands and up-regulation of genes of cholesterol biosynthesis through increased expression of SREBP2...
  56. pmc Time-resolved expression profiling of the nuclear receptor superfamily in human adipogenesis
    Mari Lahnalampi
    Department of Biosciences, University of Eastern Finland, Kuopio, Finland
    PLoS ONE 5:e12991. 2010
    ..However, many of the other 47 members of the nuclear receptor superfamily have an impact on adipogenesis, which in human cells has not been investigated in detail...
  57. ncbi The vitamin D(3) receptor in the context of the nuclear receptor superfamily : The central role of the retinoid X receptor
    C Carlberg
    Clinique de Dermatologie, Hopital Cantonal Universitaire, CH 1211, Geneve 14, Switzerland
    Endocrine 4:91-105. 1996
    ..Moreover RXR is a partner in other hormone response systems, which supports the idea that the different nuclear hormone signaling pathways are functionally linked...
  58. doi The down-regulation of the human MYC gene by the nuclear hormone 1alpha,25-dihydroxyvitamin D3 is associated with cycling of corepressors and histone deacetylases
    Sari Toropainen
    Department of Biosciences, University of Eastern Finland, FIN 70211 Kuopio, Finland
    J Mol Biol 400:284-94. 2010
    ..In conclusion, our data suggest that dynamically composed protein complexes that dock via VDR to the two VDREs may explain the repression of the MYC gene...
  59. pmc Design principles of nuclear receptor signaling: how complex networking improves signal transduction
    Alexey N Kolodkin
    Molecular Cell Physiology, VU University Amsterdam, Amsterdam, The Netherlands
    Mol Syst Biol 6:446. 2010
    ..In addition, the models developed are suitable for implementation in specific cases of NR-mediated signaling, to predict individual receptor functions and differential sensitivity toward physiological and pharmacological ligands...
  60. doi Mechanism of 1α,25-dihydroxyvitamin D(3)-dependent repression of interleukin-12B
    Petra Gynther
    Department of Biosciences, University of Eastern Finland, FI 70211 Kuopio, Finland
    Biochim Biophys Acta 1813:810-8. 2011
    ..We suggest that these repressive epigenetic changes eventually cause down-regulation of IL-12 expression. This article is part of a Special Issue entitled: 11th European Symposium on Calcium...
  61. pmc Nuclear hormone 1α,25-dihydroxyvitamin D3 elicits a genome-wide shift in the locations of VDR chromatin occupancy
    Sami Heikkinen
    Department of Biosciences, University of Eastern Finland, FIN 70210 Kuopio, Finland
    Nucleic Acids Res 39:9181-93. 2011
    ..In conclusion, ligand binding shifts the locations of VDR occupation to DR3-type REs that surround its target genes and occur in a large variety of regulatory constellations...
  62. ncbi A genomic perspective on vitamin D signaling
    Carsten Carlberg
    Life Sciences Research Unit, University of Luxembourg, Luxembourg
    Anticancer Res 29:3485-93. 2009
    ..Important cancer regulatory modules with VDREs should have a major impact on understanding the role and potential therapeutic value of VDR in cancer...
  63. pmc Cyclical chromatin looping and transcription factor association on the regulatory regions of the p21 (CDKN1A) gene in response to 1alpha,25-dihydroxyvitamin D3
    Anna Saramaki
    Department of Biosciences, University of Kuopio, FIN 70210 Kuopio, Finland
    J Biol Chem 284:8073-82. 2009
    ..In conclusion, 1alpha,25-dihydroxyvitamin D(3) regulates p21 transcription by inducing cyclical chromatin looping that depends on both histone deacetylation and demethylation...
  64. pmc Selective use of multiple vitamin D response elements underlies the 1 alpha,25-dihydroxyvitamin D3-mediated negative regulation of the human CYP27B1 gene
    Mikko M Turunen
    Department of Biochemistry, University of Kuopio, FIN 70211 Kuopio, Finland
    Nucleic Acids Res 35:2734-47. 2007
    ..This data explains, in part, why the human CYP27B1 gene is repressed in HEK-293 but not in MCF-7 cells...
  65. ncbi Vitamins as hormones
    J Reichrath
    Department of Dermatology, The Saarland University Hospital, Homburg, Germany
    Horm Metab Res 39:71-84. 2007
    ..This review summarizes existing knowledge on vitamins A and D, the major vitamin-hormones of the skin...