Research Topics
Genomes and Genes
| Carsten CarlbergSummaryAffiliation: University of Eastern Finland Location: Kuopio, Finland URL: www.uef.fi/biolaaketiede/carlberg Publications
| Collaborators
|
Detail Information
Publications
The first genome-wide view of vitamin D receptor locations and their mechanistic implicationsCarsten Carlberg
Department of Biosciences, University of Eastern Finland, P O Box 1627, FIN 70211 Kuopio, Finland
Anticancer Res 32:271-82. 2012..This review provides a detailed comparison of the insights obtained from both ChIP-Seq studies...- Subcellular localisation of BAG-1 and its regulation of vitamin D receptor-mediated transactivation and involucrin expression in oral keratinocytes: implications for oral carcinogenesisSan San Lee
Department of Oral and Dental Science, University of Bristol, Lower Maudlin Street, Bristol BS1 2LY, UK
Exp Cell Res 313:3222-38. 2007..By contrast to the cytoplasmic BAG-1 isoforms, BAG-1L may act to suppress tumorigenesis... - Functional characterization of vitamin D responding regions in the human 5-Lipoxygenase geneSabine Seuter
Institute of Pharmaceutical Chemistry, University of Frankfurt, D 60438 Frankfurt, Germany
Biochim Biophys Acta 1771:864-72. 2007..This indicates DNA looping of the TSS to even very distant gene regions. In summary, we suggest that the upregulation of the primary 1alpha,25(OH)(2)D(3) target 5-LO is mediated in vivo by a prominent VDRE in intron 4... 
Selective use of multiple vitamin D response elements underlies the 1 alpha,25-dihydroxyvitamin D3-mediated negative regulation of the human CYP27B1 geneMikko M Turunen
Department of Biochemistry, University of Kuopio, FIN 70211 Kuopio, Finland
Nucleic Acids Res 35:2734-47. 2007..This data explains, in part, why the human CYP27B1 gene is repressed in HEK-293 but not in MCF-7 cells...- Vitamins as hormonesJ Reichrath
Department of Dermatology, The Saarland University Hospital, Homburg, Germany
Horm Metab Res 39:71-84. 2007..This review summarizes existing knowledge on vitamins A and D, the major vitamin-hormones of the skin... - Epigenetic corruption of VDR signalling in malignancyS Asad Abedin
Institute of Biomedical Research, Endocrinology and Metabolism, University of Birmingham Medical School, Edgbaston, Birmingham B15 2TT, UK
Anticancer Res 26:2557-66. 2006..This molecular lesion provides a novel chemotherapy target for acceptable doses of 1alpha25(OH)2D3 plus HDAC inhibitors... - Detailed molecular understanding of agonistic and antagonistic vitamin D receptor ligandsCarsten Carlberg
Department of Biochemistry, University of Kuopio, FIN 70211 Kuopio, Finland
Curr Top Med Chem 6:1243-53. 2006..In this review we discuss the molecular mechanisms of these different type of analogues based on crystal structure data, molecular dynamics simulations and biochemical assays... - Regulation of the human p21(waf1/cip1) gene promoter via multiple binding sites for p53 and the vitamin D3 receptorAnna Saramaki
Department of Biochemistry, University of Kuopio, FIN 70211 Kuopio, Finland
Nucleic Acids Res 34:543-54. 2006..Taken together, we demonstrated that the human p21((waf1/cip1)) gene is a primary 1alpha,25(OH)2D3-responding gene with at least three VDR binding promoter regions, in two of which also p53 co-localizes... - A role of melatonin in neuroectodermal-mesodermal interactions: the hair follicle synthesizes melatonin and expresses functional melatonin receptorsHiromi Kobayashi
Department of Dermatology, University Hospital Schleswig-Holstein, , , , Germany
FASEB J 19:1710-2. 2005..As a prototypic neuroectodermal-mesodermal interaction model, the HF can be exploited for dissecting the obscure role of melatonin in such interactions in peripheral tissues... - Spatio-temporal activation of chromatin on the human CYP24 gene promoter in the presence of 1alpha,25-Dihydroxyvitamin D3Sami Väisänen
Department of Biochemistry, University of Kuopio, FIN 70211 Kuopio, Finland
J Mol Biol 350:65-77. 2005.... - Gene regulatory potential of nonsteroidal vitamin D receptor ligandsMIKAEL PERAKYLA
Department of Chemistry, University of Kuopio, P O Box 1627, FIN 70211 Kuopio, Finland
Mol Endocrinol 19:2060-73. 2005..At a noncalcemic dose of 150 microg/kg, CD4528 showed in vivo a clear induction of CYP24 expression and therefore may be used as a lead compound for the development of therapeutics against psoriasis, osteoporosis, and cancer... - The human hyaluronan synthase 2 gene is a primary retinoic acid and epidermal growth factor responding geneKatri Saavalainen
Department of Biochemistry, University of Kuopio, FIN 70211 Kuopio, Finland
J Biol Chem 280:14636-44. 2005..Taken together, the human Has2 gene is a potent primary EGF and all-trans-RA responding gene with a complex regulation... - Identification of pregnane X receptor binding sites in the regulatory regions of genes involved in bile acid homeostasisChristian Frank
Department of Biochemistry, University of Kuopio, FIN-70211 Kuopio, Finland
J Mol Biol 346:505-19. 2005..This observation increases the understanding of the physiological role of PXR in the homeostasis of bile acids in humans... - Using chromatin immunoprecipitation to monitor 1alpha,25-dihydroxyvitamin D3-dependent chromatin activity on the human CYP24 promoterSami Väisänen
Department of Biochemistry, University of Kuopio, P O Box 1627, FIN 70211 Kuopio, Finland
J Steroid Biochem Mol Biol 89:277-9. 2004..Our results suggest that ChIP is suitable for monitoring 1,25-D(3)-dependent changes of chromatin organization and can be used to reveal information about chromatin activity in living cells... - The vitamin D receptorCarsten Carlberg
Life Sciences Research Unit, Universitè of Luxembourg, 162A, avenue de la Faiencerie, L 1511 Luxembourg, Luxembourg
Dermatol Clin 25:515-23, viii. 2007..More than 3000 synthetic analogs of 1alpha,25(OH)(2)D(3) are known. This review aims to provide an overview on vitamin D signaling from the skin perspective... - Distinct HDACs regulate the transcriptional response of human cyclin-dependent kinase inhibitor genes to Trichostatin A and 1alpha,25-dihydroxyvitamin D3Marjo Malinen
Department of Biochemistry, University of Kuopio, FIN 70211 Kuopio, Finland
Nucleic Acids Res 36:121-32. 2008..This suggests that the attenuation of the response to TSA by NCoR1 or that to 1alpha,25(OH)2D3 by HDACs can be overcome by their combined application achieving maximal induction of anti-proliferative target genes... 
DICKKOPF-4 is induced by TCF/beta-catenin and upregulated in human colon cancer, promotes tumour cell invasion and angiogenesis and is repressed by 1alpha,25-dihydroxyvitamin D3N Pendas-Franco
Instituto de Investigaciones Biomedicas Alberto Sols, Consejo Superior de Investigaciones Cientificas Universidad Autonoma de Madrid, Madrid, Spain
Oncogene 27:4467-77. 2008..In conclusion, DKK-4 is upregulated in colon cancer and is associated with the acquisition of malignant properties by neoplastic cells. DKK-4 downregulation is a novel effect of 1,25(OH)2D3 that may contribute to its anticancer action...- 1,25-dihydroxyvitamin D3 influences cellular homocysteine levels in murine preosteoblastic MC3T3-E1 cells by direct regulation of cystathionine β-synthaseCarsten Kriebitzsch
Laboratory for Experimental Medicine and Endocrinology LEGENDO, Catholic University of Leuven, Leuven, Belgium
J Bone Miner Res 26:2991-3000. 2011..In conclusion, this study showed that cbs is a primary 1,25(OH)(2) D(3) target gene which renders HCY metabolism responsive to 1,25(OH)(2) D(3)... - Nuclear hormone 1α,25-dihydroxyvitamin D3 elicits a genome-wide shift in the locations of VDR chromatin occupancySami Heikkinen
Department of Biosciences, University of Eastern Finland, FIN 70210 Kuopio, Finland
Nucleic Acids Res 39:9181-93. 2011..In conclusion, ligand binding shifts the locations of VDR occupation to DR3-type REs that surround its target genes and occur in a large variety of regulatory constellations... - Cellular content of UDP-N-acetylhexosamines controls hyaluronan synthase 2 expression and correlates with O-linked N-acetylglucosamine modification of transcription factors YY1 and SP1Tiina A Jokela
Institute of Biomedicine, University of Eastern Finland, FIN 70211 Kuopio, Finland
J Biol Chem 286:33632-40. 2011.... - Mechanism of 1α,25-dihydroxyvitamin D(3)-dependent repression of interleukin-12BPetra Gynther
Department of Biosciences, University of Eastern Finland, FI 70211 Kuopio, Finland
Biochim Biophys Acta 1813:810-8. 2011..We suggest that these repressive epigenetic changes eventually cause down-regulation of IL-12 expression. This article is part of a Special Issue entitled: 11th European Symposium on Calcium... - Design principles of nuclear receptor signaling: how complex networking improves signal transductionAlexey N Kolodkin
Molecular Cell Physiology, VU University Amsterdam, Amsterdam, The Netherlands
Mol Syst Biol 6:446. 2010..In addition, the models developed are suitable for implementation in specific cases of NR-mediated signaling, to predict individual receptor functions and differential sensitivity toward physiological and pharmacological ligands... - The vitamin D(3) receptor in the context of the nuclear receptor superfamily : The central role of the retinoid X receptorC Carlberg
Clinique de Dermatologie, Hopital Cantonal Universitaire, CH 1211, Geneve 14, Switzerland
Endocrine 4:91-105. 1996..Moreover RXR is a partner in other hormone response systems, which supports the idea that the different nuclear hormone signaling pathways are functionally linked... - Time-resolved expression profiling of the nuclear receptor superfamily in human adipogenesisMari Lahnalampi
Department of Biosciences, University of Eastern Finland, Kuopio, Finland
PLoS ONE 5:e12991. 2010..However, many of the other 47 members of the nuclear receptor superfamily have an impact on adipogenesis, which in human cells has not been investigated in detail... - Cyclical regulation of the insulin-like growth factor binding protein 3 gene in response to 1alpha,25-dihydroxyvitamin D3Marjo Malinen
Department of Biosciences, University of Eastern Finland, Kuopio, Finland
Nucleic Acids Res 39:502-12. 2011..In conclusion, 1α,25(OH)(2)D(3) regulates IGFBP3 transcription through short-term cyclical association of VDR, HDAC4 and HDAC6 to both VDRE-containing chromatin regions... - The down-regulation of the human MYC gene by the nuclear hormone 1alpha,25-dihydroxyvitamin D3 is associated with cycling of corepressors and histone deacetylasesSari Toropainen
Department of Biosciences, University of Eastern Finland, FIN 70211 Kuopio, Finland
J Mol Biol 400:284-94. 2010..In conclusion, our data suggest that dynamically composed protein complexes that dock via VDR to the two VDREs may explain the repression of the MYC gene... - A genomic perspective on vitamin D signalingCarsten Carlberg
Life Sciences Research Unit, University of Luxembourg, Luxembourg
Anticancer Res 29:3485-93. 2009..Important cancer regulatory modules with VDREs should have a major impact on understanding the role and potential therapeutic value of VDR in cancer... - Cyclical chromatin looping and transcription factor association on the regulatory regions of the p21 (CDKN1A) gene in response to 1alpha,25-dihydroxyvitamin D3Anna Saramaki
Department of Biosciences, University of Kuopio, FIN 70210 Kuopio, Finland
J Biol Chem 284:8073-82. 2009..In conclusion, 1alpha,25-dihydroxyvitamin D(3) regulates p21 transcription by inducing cyclical chromatin looping that depends on both histone deacetylation and demethylation... - Coordinate induction of PPAR alpha and SREBP2 in multifunctional protein 2 deficient miceKatrin Martens
Laboratory of Cell Metabolism, Department of Pharmaceutical Sciences, K U Leuven, Leuven, Belgium
Biochim Biophys Acta 1781:694-702. 2008..These data demonstrate a tight interrelationship between induction of PPAR alpha by endogenous ligands and up-regulation of genes of cholesterol biosynthesis through increased expression of SREBP2... - Variations in the ghrelin receptor gene associate with obesity and glucose metabolism in individuals with impaired glucose toleranceUrsula Mager
Department of Clinical Nutrition, Food and Health Research Centre, University of Kuopio, Kuopio, Finland
PLoS ONE 3:e2941. 2008..Ghrelin may influence the development of obesity through its role in the control of energy balance, food intake, and regulation of body weight. The effects of ghrelin are mediated via the growth hormone secretagogue receptor (GHSR)... - The genes of the coactivator TIF2 and the corepressor SMRT are primary 1alpha,25(OH)2D3 targetsThomas W Dunlop
Department of Biochemistry, University of Kuopio, P O Box 1627, FIN 70211 Kuopio, Finland
J Steroid Biochem Mol Biol 89:257-60. 2004..We suggest that some or all of these DR3-type VDREs are responsible for the observed responsiveness of TIF2 and SMRT to 1alpha,25(OH)(2)D(3)... - Ligand-mediated conformational changes of the VDR are required for gene transactivationCarsten Carlberg
Department of Biochemistry, University of Kuopio, P O Box 1627, FIN 70211 Kuopio, Finland
J Steroid Biochem Mol Biol 89:227-32. 2004..Gemini is the first described (conditional) inverse agonist to an endocrine nuclear receptor (NR) and may function as a sensor for cell-specific CoA/CoR ratios... - The highly conserved region of the co-repressor Sin3A functionally interacts with the co-repressor AlienUdo Moehren
Genetic Institute, Justus Liebig University, Heinrich Buff Ring 58 62, D 35392 Giessen, Germany
Nucleic Acids Res 32:2995-3004. 2004..Our results therefore indicate a novel functional role of the Sin3 HCR and give novel insights into Alien-mediated gene repression... - The nuclear receptor for melatonin represses 5-lipoxygenase gene expression in human B lymphocytesD Steinhilber
Pharmazeutisches Institut, Universitat Tubingen, Germany
J Biol Chem 270:7037-40. 1995..This indicates that 5-lipoxygenase is the first natural RZR alpha responding gene. Furthermore, our results open up a new perspective in understanding the involvement of melatonin in inflammatory and immunological reactions... - Current understanding of the function of the nuclear vitamin D receptor in response to its natural and synthetic ligandsCarsten Carlberg
Department of Biochemistry, University of Kuopio, P O Box 1627, 70211 Kuopio, Finland
Recent Results Cancer Res 164:29-42. 2003..This provides them with some selectivity for DNA-dependent and -independent signaling pathways and VDRE structures... - Structural evaluation of the agonistic action of a vitamin D analog with two side chains binding to the nuclear vitamin D receptorSami Väisänen
Department of Biochemistry, University of Kuopio, P O Box 1627, FIN 70211 Kuopio, Finland
Mol Pharmacol 63:1230-7. 2003..Therefore, Gemini is an important model compound that allows further insight into the molecular actions of the VDR but is, in parallel, also a promising precursor for the design of even more potent 1alpha,25(OH)2D3 analogs... - Modulation of mouse and human phenobarbital-responsive enhancer module by nuclear receptorsJanne Mäkinen
Department of Pharmaceutics, University of Kuopio, Kuopio, Finland
Mol Pharmacol 62:366-78. 2002..Our results provide new mechanistic explanations to several previously unresolved aspects of CYP2B and CYP3A gene regulation... - Different molecular mechanisms of vitamin D(3) receptor antagonistsA Toell
, , , Germany
Mol Pharmacol 59:1478-85. 2001..In conclusion, the two 1alpha,25(OH)(2)D(3) analogs act in part via different molecular mechanisms, which allows us to speculate that ZK159222 is a more complete antagonist and TEI-9647 a more selective antagonist... - Gene regulation by melatoninC Carlberg
Institut fur Physiologische Chemie I, Heinrich Heine Universitat Dusseldorf, Postfach 10 10 07, D 40001 Dusseldorf, Germany
Ann N Y Acad Sci 917:387-96. 2000..It is hypothesized in this review that, in some cases, RZR/ROR alpha may be a primary target of membrane melatonin receptors... - Inhibitory effect of uremic solutions on protein-DNA-complex formation of the vitamin D receptor and other members of the nuclear receptor superfamilyA Toell
Institut fur Physiologische Chemie I, Heinrich Heine Universitat Dusseldorf, D 40001 Dusseldorf, Germany
J Cell Biochem 74:386-94. 1999..These results indicate that VDR is a target of substances in uremic solutions in vitro, but also to some extent other nuclear receptors (i.e., other endocrine signaling systems) may be affected by renal failure... - Genome-wide landscape of liver X receptor chromatin binding and gene regulation in human macrophagesPetri Pehkonen
School of Medicine, Institute of Biomedicine, University of Eastern Finland, FIN 70210 Kuopio, Finland
BMC Genomics 13:50. 2012..The liver X receptors (LXRs) are oxysterol sensing nuclear receptors with multiple effects on metabolism and immune cells. However, the complete genome-wide cistrome of LXR in cells of human origin has not yet been provided...