Carsten Carlberg

Summary

Affiliation: University of Eastern Finland
Location: Kuopio, Finland
URL: www.uef.fi/biolaaketiede/carlberg

Publications

  1. ncbi The first genome-wide view of vitamin D receptor locations and their mechanistic implications
    Carsten Carlberg
    Department of Biosciences, University of Eastern Finland, P O Box 1627, FIN 70211 Kuopio, Finland
    Anticancer Res 32:271-82. 2012
  2. ncbi Subcellular localisation of BAG-1 and its regulation of vitamin D receptor-mediated transactivation and involucrin expression in oral keratinocytes: implications for oral carcinogenesis
    San San Lee
    Department of Oral and Dental Science, University of Bristol, Lower Maudlin Street, Bristol BS1 2LY, UK
    Exp Cell Res 313:3222-38. 2007
  3. ncbi Functional characterization of vitamin D responding regions in the human 5-Lipoxygenase gene
    Sabine Seuter
    Institute of Pharmaceutical Chemistry, University of Frankfurt, D 60438 Frankfurt, Germany
    Biochim Biophys Acta 1771:864-72. 2007
  4. pmc Selective use of multiple vitamin D response elements underlies the 1 alpha,25-dihydroxyvitamin D3-mediated negative regulation of the human CYP27B1 gene
    Mikko M Turunen
    Department of Biochemistry, University of Kuopio, FIN 70211 Kuopio, Finland
    Nucleic Acids Res 35:2734-47. 2007
  5. ncbi Vitamins as hormones
    J Reichrath
    Department of Dermatology, The Saarland University Hospital, Homburg, Germany
    Horm Metab Res 39:71-84. 2007
  6. ncbi Epigenetic corruption of VDR signalling in malignancy
    S Asad Abedin
    Institute of Biomedical Research, Endocrinology and Metabolism, University of Birmingham Medical School, Edgbaston, Birmingham B15 2TT, UK
    Anticancer Res 26:2557-66. 2006
  7. ncbi Detailed molecular understanding of agonistic and antagonistic vitamin D receptor ligands
    Carsten Carlberg
    Department of Biochemistry, University of Kuopio, FIN 70211 Kuopio, Finland
    Curr Top Med Chem 6:1243-53. 2006
  8. pmc Regulation of the human p21(waf1/cip1) gene promoter via multiple binding sites for p53 and the vitamin D3 receptor
    Anna Saramaki
    Department of Biochemistry, University of Kuopio, FIN 70211 Kuopio, Finland
    Nucleic Acids Res 34:543-54. 2006
  9. ncbi A role of melatonin in neuroectodermal-mesodermal interactions: the hair follicle synthesizes melatonin and expresses functional melatonin receptors
    Hiromi Kobayashi
    Department of Dermatology, University Hospital Schleswig Holstein, Campus Lubeck, University of Lubeck, Lubeck, Germany
    FASEB J 19:1710-2. 2005
  10. ncbi Spatio-temporal activation of chromatin on the human CYP24 gene promoter in the presence of 1alpha,25-Dihydroxyvitamin D3
    Sami Väisänen
    Department of Biochemistry, University of Kuopio, FIN 70211 Kuopio, Finland
    J Mol Biol 350:65-77. 2005

Collaborators

Detail Information

Publications64

  1. ncbi The first genome-wide view of vitamin D receptor locations and their mechanistic implications
    Carsten Carlberg
    Department of Biosciences, University of Eastern Finland, P O Box 1627, FIN 70211 Kuopio, Finland
    Anticancer Res 32:271-82. 2012
    ..This review provides a detailed comparison of the insights obtained from both ChIP-Seq studies...
  2. ncbi Subcellular localisation of BAG-1 and its regulation of vitamin D receptor-mediated transactivation and involucrin expression in oral keratinocytes: implications for oral carcinogenesis
    San San Lee
    Department of Oral and Dental Science, University of Bristol, Lower Maudlin Street, Bristol BS1 2LY, UK
    Exp Cell Res 313:3222-38. 2007
    ..By contrast to the cytoplasmic BAG-1 isoforms, BAG-1L may act to suppress tumorigenesis...
  3. ncbi Functional characterization of vitamin D responding regions in the human 5-Lipoxygenase gene
    Sabine Seuter
    Institute of Pharmaceutical Chemistry, University of Frankfurt, D 60438 Frankfurt, Germany
    Biochim Biophys Acta 1771:864-72. 2007
    ..This indicates DNA looping of the TSS to even very distant gene regions. In summary, we suggest that the upregulation of the primary 1alpha,25(OH)(2)D(3) target 5-LO is mediated in vivo by a prominent VDRE in intron 4...
  4. pmc Selective use of multiple vitamin D response elements underlies the 1 alpha,25-dihydroxyvitamin D3-mediated negative regulation of the human CYP27B1 gene
    Mikko M Turunen
    Department of Biochemistry, University of Kuopio, FIN 70211 Kuopio, Finland
    Nucleic Acids Res 35:2734-47. 2007
    ..This data explains, in part, why the human CYP27B1 gene is repressed in HEK-293 but not in MCF-7 cells...
  5. ncbi Vitamins as hormones
    J Reichrath
    Department of Dermatology, The Saarland University Hospital, Homburg, Germany
    Horm Metab Res 39:71-84. 2007
    ..This review summarizes existing knowledge on vitamins A and D, the major vitamin-hormones of the skin...
  6. ncbi Epigenetic corruption of VDR signalling in malignancy
    S Asad Abedin
    Institute of Biomedical Research, Endocrinology and Metabolism, University of Birmingham Medical School, Edgbaston, Birmingham B15 2TT, UK
    Anticancer Res 26:2557-66. 2006
    ..The capacity of deregulated co-repressors to attenuate the responsiveness of VDR signalling in cancer models was examined...
  7. ncbi Detailed molecular understanding of agonistic and antagonistic vitamin D receptor ligands
    Carsten Carlberg
    Department of Biochemistry, University of Kuopio, FIN 70211 Kuopio, Finland
    Curr Top Med Chem 6:1243-53. 2006
    ..In this review we discuss the molecular mechanisms of these different type of analogues based on crystal structure data, molecular dynamics simulations and biochemical assays...
  8. pmc Regulation of the human p21(waf1/cip1) gene promoter via multiple binding sites for p53 and the vitamin D3 receptor
    Anna Saramaki
    Department of Biochemistry, University of Kuopio, FIN 70211 Kuopio, Finland
    Nucleic Acids Res 34:543-54. 2006
    ..Taken together, we demonstrated that the human p21((waf1/cip1)) gene is a primary 1alpha,25(OH)2D3-responding gene with at least three VDR binding promoter regions, in two of which also p53 co-localizes...
  9. ncbi A role of melatonin in neuroectodermal-mesodermal interactions: the hair follicle synthesizes melatonin and expresses functional melatonin receptors
    Hiromi Kobayashi
    Department of Dermatology, University Hospital Schleswig Holstein, Campus Lubeck, University of Lubeck, Lubeck, Germany
    FASEB J 19:1710-2. 2005
    ..As a prototypic neuroectodermal-mesodermal interaction model, the HF can be exploited for dissecting the obscure role of melatonin in such interactions in peripheral tissues...
  10. ncbi Spatio-temporal activation of chromatin on the human CYP24 gene promoter in the presence of 1alpha,25-Dihydroxyvitamin D3
    Sami Väisänen
    Department of Biochemistry, University of Kuopio, FIN 70211 Kuopio, Finland
    J Mol Biol 350:65-77. 2005
    ....
  11. ncbi Gene regulatory potential of nonsteroidal vitamin D receptor ligands
    MIKAEL PERAKYLA
    Department of Chemistry, University of Kuopio, P O Box 1627, FIN 70211 Kuopio, Finland
    Mol Endocrinol 19:2060-73. 2005
    ..At a noncalcemic dose of 150 microg/kg, CD4528 showed in vivo a clear induction of CYP24 expression and therefore may be used as a lead compound for the development of therapeutics against psoriasis, osteoporosis, and cancer...
  12. ncbi The human hyaluronan synthase 2 gene is a primary retinoic acid and epidermal growth factor responding gene
    Katri Saavalainen
    Department of Biochemistry, University of Kuopio, FIN 70211 Kuopio, Finland
    J Biol Chem 280:14636-44. 2005
    ..Taken together, the human Has2 gene is a potent primary EGF and all-trans-RA responding gene with a complex regulation...
  13. ncbi Identification of pregnane X receptor binding sites in the regulatory regions of genes involved in bile acid homeostasis
    Christian Frank
    Department of Biochemistry, University of Kuopio, FIN 70211 Kuopio, Finland
    J Mol Biol 346:505-19. 2005
    ..This observation increases the understanding of the physiological role of PXR in the homeostasis of bile acids in humans...
  14. ncbi Using chromatin immunoprecipitation to monitor 1alpha,25-dihydroxyvitamin D3-dependent chromatin activity on the human CYP24 promoter
    Sami Väisänen
    Department of Biochemistry, University of Kuopio, P O Box 1627, FIN 70211 Kuopio, Finland
    J Steroid Biochem Mol Biol 89:277-9. 2004
    ..Our results suggest that ChIP is suitable for monitoring 1,25-D(3)-dependent changes of chromatin organization and can be used to reveal information about chromatin activity in living cells...
  15. ncbi The vitamin D receptor
    Carsten Carlberg
    Life Sciences Research Unit, Universitè of Luxembourg, 162A, avenue de la Faiencerie, L 1511 Luxembourg, Luxembourg
    Dermatol Clin 25:515-23, viii. 2007
    ..More than 3000 synthetic analogs of 1alpha,25(OH)(2)D(3) are known. This review aims to provide an overview on vitamin D signaling from the skin perspective...
  16. pmc Distinct HDACs regulate the transcriptional response of human cyclin-dependent kinase inhibitor genes to Trichostatin A and 1alpha,25-dihydroxyvitamin D3
    Marjo Malinen
    Department of Biochemistry, University of Kuopio, FIN 70211 Kuopio, Finland
    Nucleic Acids Res 36:121-32. 2008
    ..This suggests that the attenuation of the response to TSA by NCoR1 or that to 1alpha,25(OH)2D3 by HDACs can be overcome by their combined application achieving maximal induction of anti-proliferative target genes...
  17. doi DICKKOPF-4 is induced by TCF/beta-catenin and upregulated in human colon cancer, promotes tumour cell invasion and angiogenesis and is repressed by 1alpha,25-dihydroxyvitamin D3
    N Pendas-Franco
    Instituto de Investigaciones Biomedicas Alberto Sols, Consejo Superior de Investigaciones Cientificas Universidad Autonoma de Madrid, Madrid, Spain
    Oncogene 27:4467-77. 2008
    ..In conclusion, DKK-4 is upregulated in colon cancer and is associated with the acquisition of malignant properties by neoplastic cells. DKK-4 downregulation is a novel effect of 1,25(OH)2D3 that may contribute to its anticancer action...
  18. pmc 1,25-dihydroxyvitamin D3 influences cellular homocysteine levels in murine preosteoblastic MC3T3-E1 cells by direct regulation of cystathionine β-synthase
    Carsten Kriebitzsch
    Laboratory for Experimental Medicine and Endocrinology LEGENDO, Catholic University of Leuven, Leuven, Belgium
    J Bone Miner Res 26:2991-3000. 2011
    ..In conclusion, this study showed that cbs is a primary 1,25(OH)(2) D(3) target gene which renders HCY metabolism responsive to 1,25(OH)(2) D(3)...
  19. pmc Nuclear hormone 1α,25-dihydroxyvitamin D3 elicits a genome-wide shift in the locations of VDR chromatin occupancy
    Sami Heikkinen
    Department of Biosciences, University of Eastern Finland, FIN 70210 Kuopio, Finland
    Nucleic Acids Res 39:9181-93. 2011
    ..In conclusion, ligand binding shifts the locations of VDR occupation to DR3-type REs that surround its target genes and occur in a large variety of regulatory constellations...
  20. pmc Cellular content of UDP-N-acetylhexosamines controls hyaluronan synthase 2 expression and correlates with O-linked N-acetylglucosamine modification of transcription factors YY1 and SP1
    Tiina A Jokela
    Institute of Biomedicine, University of Eastern Finland, FIN 70211 Kuopio, Finland
    J Biol Chem 286:33632-40. 2011
    ....
  21. doi Mechanism of 1α,25-dihydroxyvitamin D(3)-dependent repression of interleukin-12B
    Petra Gynther
    Department of Biosciences, University of Eastern Finland, FI 70211 Kuopio, Finland
    Biochim Biophys Acta 1813:810-8. 2011
    ..We suggest that these repressive epigenetic changes eventually cause down-regulation of IL-12 expression. This article is part of a Special Issue entitled: 11th European Symposium on Calcium...
  22. pmc Design principles of nuclear receptor signaling: how complex networking improves signal transduction
    Alexey N Kolodkin
    Molecular Cell Physiology, VU University Amsterdam, Amsterdam, The Netherlands
    Mol Syst Biol 6:446. 2010
    ..In addition, the models developed are suitable for implementation in specific cases of NR-mediated signaling, to predict individual receptor functions and differential sensitivity toward physiological and pharmacological ligands...
  23. ncbi The vitamin D(3) receptor in the context of the nuclear receptor superfamily : The central role of the retinoid X receptor
    C Carlberg
    Clinique de Dermatologie, Hopital Cantonal Universitaire, CH 1211, Geneve 14, Switzerland
    Endocrine 4:91-105. 1996
    ..Moreover RXR is a partner in other hormone response systems, which supports the idea that the different nuclear hormone signaling pathways are functionally linked...
  24. pmc Time-resolved expression profiling of the nuclear receptor superfamily in human adipogenesis
    Mari Lahnalampi
    Department of Biosciences, University of Eastern Finland, Kuopio, Finland
    PLoS ONE 5:e12991. 2010
    ..However, many of the other 47 members of the nuclear receptor superfamily have an impact on adipogenesis, which in human cells has not been investigated in detail...
  25. pmc Cyclical regulation of the insulin-like growth factor binding protein 3 gene in response to 1alpha,25-dihydroxyvitamin D3
    Marjo Malinen
    Department of Biosciences, University of Eastern Finland, Kuopio, Finland
    Nucleic Acids Res 39:502-12. 2011
    ..In conclusion, 1α,25(OH)(2)D(3) regulates IGFBP3 transcription through short-term cyclical association of VDR, HDAC4 and HDAC6 to both VDRE-containing chromatin regions...
  26. doi The down-regulation of the human MYC gene by the nuclear hormone 1alpha,25-dihydroxyvitamin D3 is associated with cycling of corepressors and histone deacetylases
    Sari Toropainen
    Department of Biosciences, University of Eastern Finland, FIN 70211 Kuopio, Finland
    J Mol Biol 400:284-94. 2010
    ..In conclusion, our data suggest that dynamically composed protein complexes that dock via VDR to the two VDREs may explain the repression of the MYC gene...
  27. ncbi A genomic perspective on vitamin D signaling
    Carsten Carlberg
    Life Sciences Research Unit, University of Luxembourg, Luxembourg
    Anticancer Res 29:3485-93. 2009
    ..Important cancer regulatory modules with VDREs should have a major impact on understanding the role and potential therapeutic value of VDR in cancer...
  28. pmc Cyclical chromatin looping and transcription factor association on the regulatory regions of the p21 (CDKN1A) gene in response to 1alpha,25-dihydroxyvitamin D3
    Anna Saramaki
    Department of Biosciences, University of Kuopio, FIN 70210 Kuopio, Finland
    J Biol Chem 284:8073-82. 2009
    ..In conclusion, 1alpha,25-dihydroxyvitamin D(3) regulates p21 transcription by inducing cyclical chromatin looping that depends on both histone deacetylation and demethylation...
  29. doi Coordinate induction of PPAR alpha and SREBP2 in multifunctional protein 2 deficient mice
    Katrin Martens
    Laboratory of Cell Metabolism, Department of Pharmaceutical Sciences, K U Leuven, Leuven, Belgium
    Biochim Biophys Acta 1781:694-702. 2008
    ..These data demonstrate a tight interrelationship between induction of PPAR alpha by endogenous ligands and up-regulation of genes of cholesterol biosynthesis through increased expression of SREBP2...
  30. pmc Variations in the ghrelin receptor gene associate with obesity and glucose metabolism in individuals with impaired glucose tolerance
    Ursula Mager
    Department of Clinical Nutrition, Food and Health Research Centre, University of Kuopio, Kuopio, Finland
    PLoS ONE 3:e2941. 2008
    ..Ghrelin may influence the development of obesity through its role in the control of energy balance, food intake, and regulation of body weight. The effects of ghrelin are mediated via the growth hormone secretagogue receptor (GHSR)...
  31. ncbi The genes of the coactivator TIF2 and the corepressor SMRT are primary 1alpha,25(OH)2D3 targets
    Thomas W Dunlop
    Department of Biochemistry, University of Kuopio, P O Box 1627, FIN 70211 Kuopio, Finland
    J Steroid Biochem Mol Biol 89:257-60. 2004
    ..We suggest that some or all of these DR3-type VDREs are responsible for the observed responsiveness of TIF2 and SMRT to 1alpha,25(OH)(2)D(3)...
  32. ncbi Ligand-mediated conformational changes of the VDR are required for gene transactivation
    Carsten Carlberg
    Department of Biochemistry, University of Kuopio, P O Box 1627, FIN 70211 Kuopio, Finland
    J Steroid Biochem Mol Biol 89:227-32. 2004
    ..Gemini is the first described (conditional) inverse agonist to an endocrine nuclear receptor (NR) and may function as a sensor for cell-specific CoA/CoR ratios...
  33. pmc The highly conserved region of the co-repressor Sin3A functionally interacts with the co-repressor Alien
    Udo Moehren
    Genetic Institute, Justus Liebig University, Heinrich Buff Ring 58 62, D 35392 Giessen, Germany
    Nucleic Acids Res 32:2995-3004. 2004
    ..Our results therefore indicate a novel functional role of the Sin3 HCR and give novel insights into Alien-mediated gene repression...
  34. ncbi The nuclear receptor for melatonin represses 5-lipoxygenase gene expression in human B lymphocytes
    D Steinhilber
    Pharmazeutisches Institut, Universitat Tubingen, Germany
    J Biol Chem 270:7037-40. 1995
    ..This indicates that 5-lipoxygenase is the first natural RZR alpha responding gene. Furthermore, our results open up a new perspective in understanding the involvement of melatonin in inflammatory and immunological reactions...
  35. ncbi Current understanding of the function of the nuclear vitamin D receptor in response to its natural and synthetic ligands
    Carsten Carlberg
    Department of Biochemistry, University of Kuopio, P O Box 1627, 70211 Kuopio, Finland
    Recent Results Cancer Res 164:29-42. 2003
    ..This provides them with some selectivity for DNA-dependent and -independent signaling pathways and VDRE structures...
  36. ncbi Structural evaluation of the agonistic action of a vitamin D analog with two side chains binding to the nuclear vitamin D receptor
    Sami Väisänen
    Department of Biochemistry, University of Kuopio, P O Box 1627, FIN 70211 Kuopio, Finland
    Mol Pharmacol 63:1230-7. 2003
    ..Therefore, Gemini is an important model compound that allows further insight into the molecular actions of the VDR but is, in parallel, also a promising precursor for the design of even more potent 1alpha,25(OH)2D3 analogs...
  37. ncbi Modulation of mouse and human phenobarbital-responsive enhancer module by nuclear receptors
    Janne Mäkinen
    Department of Pharmaceutics, University of Kuopio, Kuopio, Finland
    Mol Pharmacol 62:366-78. 2002
    ..Our results provide new mechanistic explanations to several previously unresolved aspects of CYP2B and CYP3A gene regulation...
  38. ncbi Different molecular mechanisms of vitamin D(3) receptor antagonists
    A Toell
    , , , Germany
    Mol Pharmacol 59:1478-85. 2001
    ..In conclusion, the two 1alpha,25(OH)(2)D(3) analogs act in part via different molecular mechanisms, which allows us to speculate that ZK159222 is a more complete antagonist and TEI-9647 a more selective antagonist...
  39. ncbi Gene regulation by melatonin
    C Carlberg
    Institut fur Physiologische Chemie I, Heinrich Heine Universitat Dusseldorf, Postfach 10 10 07, D 40001 Dusseldorf, Germany
    Ann N Y Acad Sci 917:387-96. 2000
    ..It is hypothesized in this review that, in some cases, RZR/ROR alpha may be a primary target of membrane melatonin receptors...
  40. ncbi Inhibitory effect of uremic solutions on protein-DNA-complex formation of the vitamin D receptor and other members of the nuclear receptor superfamily
    A Toell
    Institut fur Physiologische Chemie I, Heinrich Heine Universitat Dusseldorf, D 40001 Dusseldorf, Germany
    J Cell Biochem 74:386-94. 1999
    ..These results indicate that VDR is a target of substances in uremic solutions in vitro, but also to some extent other nuclear receptors (i.e., other endocrine signaling systems) may be affected by renal failure...
  41. pmc Genome-wide landscape of liver X receptor chromatin binding and gene regulation in human macrophages
    Petri Pehkonen
    School of Medicine, Institute of Biomedicine, University of Eastern Finland, FIN 70210 Kuopio, Finland
    BMC Genomics 13:50. 2012
    ..The liver X receptors (LXRs) are oxysterol sensing nuclear receptors with multiple effects on metabolism and immune cells. However, the complete genome-wide cistrome of LXR in cells of human origin has not yet been provided...