Daniel P Cardinali

Summary

Publications

  1. ncbi request reprint Disrupted chronobiology of sleep and cytoprotection in obesity: possible therapeutic value of melatonin
    Daniel P Cardinali
    Departamento de Docencia e Investigación, Pontificia Universidad Católica Argentina, Buenos Aires, Argentina
    Neuro Endocrinol Lett 32:588-606. 2011
  2. pmc Cadmium-Induced Disruption in 24-h Expression of Clock and Redox Enzyme Genes in Rat Medial Basal Hypothalamus: Prevention by Melatonin
    Vanesa Jimenez-Ortega
    Departamento de Bioquimica y Biologia Molecular III, Universidad Complutense Facultad de Medicina, Spain
    Front Neurol 2:13. 2011
  3. doi request reprint Melatonin and mitochondrial dysfunction in the central nervous system
    Daniel P Cardinali
    Pontificia Universidad Católica Argentina, Facultad de Ciencias Medicas, 1107 Buenos Aires, Argentina
    Horm Behav 63:322-30. 2013
  4. pmc Melatonin may curtail the metabolic syndrome: studies on initial and fully established fructose-induced metabolic syndrome in rats
    Daniel P Cardinali
    Department of Teaching and Research, Faculty of Medical Sciences, Pontificia Universidad Católica Argentina, 1107 Buenos Aires, Argentina
    Int J Mol Sci 14:2502-14. 2013
  5. ncbi request reprint Melatonin and its analogs in insomnia and depression
    Daniel P Cardinali
    Departmento de Docencia e Investigación, Facultad de Ciencias Medicas, Pontificia Universidad Católica Argentina, Buenos Aires, Argentina
    J Pineal Res 52:365-75. 2012
  6. doi request reprint Melatonin and the metabolic syndrome: physiopathologic and therapeutical implications
    Daniel P Cardinali
    Departamento de Docencia e Investigación, Facultad de Ciencias Medicas, Pontificia Universidad Católica Argentina, Buenos Aires, Argentina
    Neuroendocrinology 93:133-42. 2011
  7. ncbi request reprint Melatonin in Chagas' disease. Possible therapeutic value
    Daniel P Cardinali
    Pontificia Universidad Católica Argentina, Buenos Aires
    Medicina (B Aires) 71:477-83. 2011
  8. ncbi request reprint The use of chronobiotics in the resynchronization of the sleep/wake cycle. Therapeutical application in the early phases of Alzheimer's disease
    Daniel P Cardinali
    Departamento de Docencia e Investigación, Facultad de Ciencias Medicas, Pontificia Universidad Católica Argentina, Buenos Aires, Argentina
    Recent Pat Endocr Metab Immune Drug Discov 5:80-90. 2011
  9. doi request reprint Heart rate variability response to mental arithmetic stress is abnormal in first-degree relatives of individuals with schizophrenia
    Mariana N Castro
    Departments of Neurology and Psychiatry, Fundación Lucha contra Enfermedades Neurológicas de la Infancia FLENI, Buenos Aires, Argentina
    Schizophr Res 109:134-40. 2009
  10. ncbi request reprint Effect of ethanol on 24-h hormonal changes in prolactin release mechanisms in growing male rats
    Vanesa Jimenez-Ortega
    Departamento de Bioquimica y Biologia Molecular III, Facultad de Medicina, Universidad Complutense, 28040 Madrid, Spain
    Endocrine 30:269-78. 2006

Collaborators

Detail Information

Publications55

  1. ncbi request reprint Disrupted chronobiology of sleep and cytoprotection in obesity: possible therapeutic value of melatonin
    Daniel P Cardinali
    Departamento de Docencia e Investigación, Pontificia Universidad Católica Argentina, Buenos Aires, Argentina
    Neuro Endocrinol Lett 32:588-606. 2011
    ..In view that the relative potencies of the analogs are higher than that of the natural compound, clinical trials employing melatonin doses in the range of 50-100 mg/day are needed to assess its therapeutic value in MS...
  2. pmc Cadmium-Induced Disruption in 24-h Expression of Clock and Redox Enzyme Genes in Rat Medial Basal Hypothalamus: Prevention by Melatonin
    Vanesa Jimenez-Ortega
    Departamento de Bioquimica y Biologia Molecular III, Universidad Complutense Facultad de Medicina, Spain
    Front Neurol 2:13. 2011
    ..The results indicate that the interfering effect of melatonin on the activity of a low dose of CdCl(2) on MBH clock and redox enzyme genes is mainly exerted at the level of redox enzyme gene expression...
  3. doi request reprint Melatonin and mitochondrial dysfunction in the central nervous system
    Daniel P Cardinali
    Pontificia Universidad Católica Argentina, Facultad de Ciencias Medicas, 1107 Buenos Aires, Argentina
    Horm Behav 63:322-30. 2013
    ....
  4. pmc Melatonin may curtail the metabolic syndrome: studies on initial and fully established fructose-induced metabolic syndrome in rats
    Daniel P Cardinali
    Department of Teaching and Research, Faculty of Medical Sciences, Pontificia Universidad Católica Argentina, 1107 Buenos Aires, Argentina
    Int J Mol Sci 14:2502-14. 2013
    ..The results underline a possible therapeutical role of melatonin in the metabolic syndrome, both at initial and established phases...
  5. ncbi request reprint Melatonin and its analogs in insomnia and depression
    Daniel P Cardinali
    Departmento de Docencia e Investigación, Facultad de Ciencias Medicas, Pontificia Universidad Católica Argentina, Buenos Aires, Argentina
    J Pineal Res 52:365-75. 2012
    ..Hence, clinical trials employing melatonin doses in the range of 50-100mg/day are warranted before the relative merits of the melatonin analogs versus melatonin can be settled...
  6. doi request reprint Melatonin and the metabolic syndrome: physiopathologic and therapeutical implications
    Daniel P Cardinali
    Departamento de Docencia e Investigación, Facultad de Ciencias Medicas, Pontificia Universidad Católica Argentina, Buenos Aires, Argentina
    Neuroendocrinology 93:133-42. 2011
    ....
  7. ncbi request reprint Melatonin in Chagas' disease. Possible therapeutic value
    Daniel P Cardinali
    Pontificia Universidad Católica Argentina, Buenos Aires
    Medicina (B Aires) 71:477-83. 2011
    ....
  8. ncbi request reprint The use of chronobiotics in the resynchronization of the sleep/wake cycle. Therapeutical application in the early phases of Alzheimer's disease
    Daniel P Cardinali
    Departamento de Docencia e Investigación, Facultad de Ciencias Medicas, Pontificia Universidad Católica Argentina, Buenos Aires, Argentina
    Recent Pat Endocr Metab Immune Drug Discov 5:80-90. 2011
    ..The analysis of published evidence and patents indicates that melatonin can be a useful ad-on therapeutic tool in the early phases of AD...
  9. doi request reprint Heart rate variability response to mental arithmetic stress is abnormal in first-degree relatives of individuals with schizophrenia
    Mariana N Castro
    Departments of Neurology and Psychiatry, Fundación Lucha contra Enfermedades Neurológicas de la Infancia FLENI, Buenos Aires, Argentina
    Schizophr Res 109:134-40. 2009
    ..Schizophrenia patients exhibit an abnormal autonomic response to mental stress. We sought to determine the cardiac autonomic response to mental arithmetic stress in their unaffected first-degree relatives...
  10. ncbi request reprint Effect of ethanol on 24-h hormonal changes in prolactin release mechanisms in growing male rats
    Vanesa Jimenez-Ortega
    Departamento de Bioquimica y Biologia Molecular III, Facultad de Medicina, Universidad Complutense, 28040 Madrid, Spain
    Endocrine 30:269-78. 2006
    ..Ethanol augmented pituitary levels of DOPAC and 5-HIAA. The results indicate that chronic ethanol administration affects the mechanisms that modulate the circadian variation of prolactin release in growing male rats...
  11. doi request reprint Melatonin effect on plasma adiponectin, leptin, insulin, glucose, triglycerides and cholesterol in normal and high fat-fed rats
    María J Ríos-Lugo
    Departamento de Bioquimica y Biologia Molecular III, Facultad de Medicina, Universidad Complutense, Madrid, Spain
    J Pineal Res 49:342-8. 2010
    ..The results indicate that melatonin counteracts some of the disrupting effects of diet-induced obesity in rats...
  12. doi request reprint Effect of a high-fat diet on 24-h pattern of circulating levels of prolactin, luteinizing hormone, testosterone, corticosterone, thyroid-stimulating hormone and glucose, and pineal melatonin content, in rats
    Pilar Cano
    Departamento de Bioquimica y Biologia Molecular III, Facultad de Medicina, Universidad Complutense, Madrid, 28040, Spain
    Endocrine 33:118-25. 2008
    ..The amplitude of the nocturnal pineal melatonin peak decreased significantly in high-fat fed rats. The results underlie the significant effects that obesity has on circadian organization of hormone secretion...
  13. doi request reprint Effect of a high-fat diet on 24-hour pattern of circulating adipocytokines in rats
    Pilar Cano
    Departamento de Bioquimica y Biologia Molecular III, Facultad de Medicina, Universidad Complutense, Madrid, Spain
    Obesity (Silver Spring) 17:1866-71. 2009
    ....
  14. ncbi request reprint 24-hour pattern of circulating prolactin and growth hormone levels and submaxillary lymph node immune responses in growing male rats subjected to social isolation
    Ana I Esquifino
    Departamento de Bioquimica y Biologia Molecular III, Facultad de Medicina, Universidad Complutense, 28040 Madrid, Spain
    Endocrine 25:41-8. 2004
    ..Modifications in mean value and 24-h rhythmicity of plasma prolactin and GH levels are presumably involved in the effect of social isolation on immune responsiveness...
  15. ncbi request reprint Melatonin restores endothelium-dependent relaxation in aortic rings of pancreatectomized rats
    Carlos F Reyes-Toso
    Department of Physiology, Faculty of Medicine, University of Buenos Aires, Buenos Aires, Argentina
    J Pineal Res 39:386-91. 2005
    ..The results further support the improvement by melatonin of the endothelial-mediated relaxation in blood vessels of diabetic rats...
  16. ncbi request reprint Melatonin and the immune system in aging
    Daniel P Cardinali
    Departamento de Fisiologia, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina
    Neuroimmunomodulation 15:272-8. 2008
    ..The production and release of various cytokines from natural killer cells and T helper lymphocytes are enhanced by melatonin. Melatonin has the potential therapeutic value to enhance immune function in aged individuals...
  17. ncbi request reprint Twenty-four-hour rhythms of mitogenic responses, lymphocyte subset populations and amino acid content in submaxillary lymph nodes of growing male rats subjected to calorie restriction
    Ana I Esquifino
    Departamento de Bioquimica y Biologia Molecular III, Facultad de Medicina, Universidad Complutense, 28040 Madrid, Spain
    J Neuroimmunol 156:66-73. 2004
    ..Availability of nutrients presumably affects the mechanisms that modulate the circadian variation of immune responsiveness in growing rats...
  18. ncbi request reprint Neuroendocrine-immune correlates of circadian physiology: studies in experimental models of arthritis, ethanol feeding, aging, social isolation, and calorie restriction
    Ana I Esquifino
    Departamento de Bioquimica y Biologia Molecular III, Facultad de Medicina, Universidad Complutense, 28040, Madrid, Spain
    Endocrine 32:1-19. 2007
    ..In every case the experimental manipulation used perturbed the temporal organization by affecting the shape and amplitude of a rhythm or by modifying the intrinsic oscillatory mechanism itself...
  19. doi request reprint Effect of aging on 24-hour pattern of stress hormones and leptin in rats
    Pilar Cano
    Departamento de Bioquimica y Biologia Molecular III, Facultad de Medicina, Universidad Complutense, Madrid, Spain
    Life Sci 83:142-8. 2008
    ..Likewise, plasma leptin correlated with plasma corticosterone only in young rats. These changes can be attributed to a disrupting effect of aging on the homeostatic mechanisms modulating HPA activity and leptin release...
  20. ncbi request reprint Effect of ethanol on 24-hour hormonal changes in peripubertal male rats
    Vanessa Jimenez
    Departamento de Bioquimica y Biologia Molecular III, Facultad de Medicina, Universidad Complutense, Avda Complutense s n, 28040 Madrid, Spain
    Alcohol 34:127-32. 2004
    ..Chronic ethanol administration presumably affects the endogenous clock that modulates the circadian variation of the pituitary-gonadal axis and thyrotropin release in growing male rats...
  21. ncbi request reprint Age-related changes in 24-hour rhythms of norepinephrine content and serotonin turnover in rat pineal gland: effect of melatonin treatment
    David Pazo
    Departamento de Bioquimica y Biologia Molecular III, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina
    Neurosignals 11:81-7. 2002
    ..Impairment of pineal melatonin synthesizing capacity and intrapineal responses to melatonin may underlie pineal aging in rats...
  22. pmc Effect of rabbit doe-litter separation on 24-hour changes of luteinizing hormone, follicle stimulating hormone and prolactin release in female and male suckling pups
    Pilar Cano
    Departamento de Bioquimica y Biologia Molecular III, Facultad de Medicina, Universidad Complutense de Madrid, Spain
    Reprod Biol Endocrinol 3:50. 2005
    ..e., 48 h) doe-litter separation...
  23. ncbi request reprint Effect of aging on 24-hour changes in dopamine and serotonin turnover and amino acid and somatostatin contents of rat corpus striatum
    Ana I Esquifino
    Departamento de Bioquimica y Biologia Molecular III, Facultad de Medicina, Universidad Complutense, Madrid, Spain
    Neurosignals 11:336-44. 2002
    ..Some of the circadian modifications of motor function seen in aging rats could be related to the striatal transmitter changes reported herein...
  24. doi request reprint Nonlinear analysis of heart rate variability within independent frequency components during the sleep-wake cycle
    Daniel E Vigo
    Departamento de Fisiologia, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina
    Auton Neurosci 154:84-8. 2010
    ..19+/-0.03, REM: 0.14+/-0.03, p<0.001) at SWS. REM was similar to wake status regarding nonlinear HRV. We propose nonlinear HRV is a useful index of the autonomic activity that characterizes the different sleep-wake cycle stages...
  25. ncbi request reprint 24-hour changes in ACTH, corticosterone, growth hormone, and leptin levels in young male rats subjected to calorie restriction
    Fernando Chacon
    Departamento de Bioquimica y Biologia Molecular III, Facultad de Medicina, Universidad Complutense, Madrid, Spain
    Chronobiol Int 22:253-65. 2005
    ..The changes in the secretory pattern of hormones hereby reported may be part of the neuroendocrine and metabolic mechanisms evolved to maximize survival during periods of food shortage...
  26. ncbi request reprint Heart rate variability response to mental arithmetic stress in patients with schizophrenia: autonomic response to stress in schizophrenia
    Mariana N Castro
    Department of Neurology, Fundación Lucha contra Enfermedades Neurológicas de la Infancia FLENI, Buenos Aires, Argentina
    Schizophr Res 99:294-303. 2008
    ..The vulnerability-stress hypothesis is an established model of schizophrenia symptom formation. We sought to characterise the pattern of the cardiac autonomic response to mental arithmetic stress in patients with stable schizophrenia...
  27. doi request reprint Effect of cadmium on 24-hour pattern in expression of redox enzyme and clock genes in rat medial basal hypothalamus
    Vanesa Jimenez-Ortega
    Departamento de Bioquimica y Biologia Molecular III, Facultad de Medicina, Universidad Complutense, Madrid, Spain
    Biometals 23:327-37. 2010
    ..The results are compatible with the view that a low amount of Cd given in tap water brought about significant changes in circadian expression of redox enzyme and clock genes in rat MBH...
  28. doi request reprint Activity-rest rhythm abnormalities in Parkinson's disease patients are related to dopaminergic therapy
    Santiago Perez-Lloret
    Movement Disorders Section, Raul Carrea Institute for Neurological Research, FLENI, Buenos Aires, Argentina
    Int J Neurosci 120:11-6. 2010
    ..e., dopaminergic therapy or DT) with "de novo" patients and healthy controls and to correlate these parameters with self-reported sleep disturbances...
  29. doi request reprint Sleep habits, alertness, cortisol levels, and cardiac autonomic activity in short-distance bus drivers: differences between morning and afternoon shifts
    Joaquín J Diez
    Departamento de Fisiologia, Universidad Austral, Buenos Aires, Argentina
    J Occup Environ Med 53:806-11. 2011
    ..To evaluate sleep, alertness, salivary cortisol levels, and autonomic activity in the afternoon and morning shifts of a sample of short-distance bus drivers...
  30. ncbi request reprint Nonlinear analysis of heart rate variability in patients with eating disorders
    Daniel E Vigo
    Fundacion para la Lucha contra las Enfermedades Neurologicas de la Infancia FLENI, Buenos Aires, Argentina
    World J Biol Psychiatry 9:183-9. 2008
    ..Low-frequency heart rate variability was decreased in patients with anorexia. In conclusion, these results are compatible with the view that a more severe alteration of cardiac autonomic function is present in anorexia than in bulimia...
  31. pmc Sleep and quality of life in urban poverty: the effect of a slum housing upgrading program
    Guido Simonelli
    Departamento de Docencia e Investigación, Facultad de Ciencias Medicas, Pontificia Universidad Católica Argentina, Argentina
    Sleep 36:1669-76. 2013
    ..To evaluate the effect of a housing transition on sleep quality and quality of life in slum dwellers, participating in a slum housing upgrading program...
  32. ncbi request reprint Effect of chronic ethanol feeding on 24-hour rhythms of mitogenic responses and lymphocyte subset populations in thymus and spleen of peripubertal male rats
    Vanessa Jimenez
    Departamento de Bioquimica y Biologia Molecular III, Facultad de Medicina, Universidad Complutense, Madrid, Spain
    Neuroimmunomodulation 12:357-65. 2005
    ..Chronic ethanol administration presumably affects the endogenous clock that modulates the circadian variation of immune responsiveness in growing rats...
  33. ncbi request reprint Gender-related differences in urinary 6-sulfatoxymelatonin levels in obese pubertal individuals
    Hugo L Fideleff
    Departmento de Endocrinologia, Hospital T Alvarez, Buenos Aires, Argentina
    J Pineal Res 40:214-8. 2006
    ..To what extent this increase in melatonin production contributes to a delayed puberty in some pubertal obese males remains to be established...
  34. doi request reprint Mood, Th-1/Th-2 cytokine profile, and autonomic activity in older adults with acute/decompensated heart failure: preliminary observations
    Salvador M Guinjoan
    Fundacion para la Lucha contra las Enfermedades Neurologicas de la Infancia, Buenos Aires, Argentina
    World J Biol Psychiatry 10:913-8. 2009
    ....
  35. doi request reprint Heart rate nonlinear dynamics during sudden hypoxia at 8230 m simulated altitude
    Daniel E Vigo
    Departamento de Docencia e Investigación, Facultad de Ciencias Medicas, Pontificia Universidad Católica Argentina, Buenos Aires, Argentina
    Wilderness Environ Med 21:4-10. 2010
    ..Although changes in nonlinear HRV can be associated with physiologic stress and are relevant predictors of fatal arrhythmias in ischemic heart disease, to what extent these components vary in sudden hypobaric hypoxia is not known...
  36. ncbi request reprint In vitro effect of melatonin on oxygen consumption in liver mitochondria of rats
    Carlos F Reyes-Toso
    Departamento de Fisiologia and Hospital de Clinicas, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina
    Neuro Endocrinol Lett 24:341-4. 2003
    ..To examine the in vitro effect of melatonin on rat mitochondrial liver respiration...
  37. ncbi request reprint The use of chronobiotics in the resynchronization of the sleep-wake cycle
    Daniel P Cardinali
    Department of Physiology, Faculty of Medicine, University of Buenos Aires, Paraguay 2155, 1121, Buenos Aires, Argentina
    Cancer Causes Control 17:601-9. 2006
    ..Both in aged subjects having very minimal sleep disorders as well as in demented patients with a very severe disorganization of the sleep-wake cycle, melatonin treatment reduced the variability of sleep onset and restored sleep...
  38. pmc A multi-step pathway connecting short sleep duration to daytime somnolence, reduced attention, and poor academic performance: an exploratory cross-sectional study in teenagers
    Santiago Perez-Lloret
    Departamento de Docencia e Investigación, Facultad de Ciencias Medicas, Universidad Catolica Argentina, Buenos Aires, Argentina
    J Clin Sleep Med 9:469-73. 2013
    ..However this hypothesis has never been explored...
  39. ncbi request reprint 24-hour changes in circulating prolactin, follicle-stimulating hormone, luteinizing hormone, and testosterone in young male rats subjected to calorie restriction
    Fernando Chacon
    Departamento de Bioquimica y Biologia Molecular III, Facultad de Medicina, Universidad Complutense, Madrid, Spain
    Chronobiol Int 21:393-404. 2004
    ..Availability of nutrients presumably affects the mechanisms that modulate the circadian variation of the pituitary-gonadal axis in growing male rats...
  40. pmc Immune response after experimental allergic encephalomyelitis in rats subjected to calorie restriction
    Ana I Esquifino
    Departamento de Bioquimica y Biologia Molecular III, Facultad de Medicina, Universidad Complutense, Madrid, Spain
    J Neuroinflammation 4:6. 2007
    ..The results are compatible with the view that the acute phase of EAE can be curtailed by severe calorie restriction, presumably through impaired IFN-gamma production...
  41. doi request reprint Melatonin as a therapeutic tool in ophthalmology: implications for glaucoma and uveitis
    Ruth E Rosenstein
    Department of Human Biochemistry, School of Medicine, CEFYBO, University of Buenos Aires, CONICET, Buenos Aires, Argentina
    J Pineal Res 49:1-13. 2010
    ....
  42. ncbi request reprint Cerebroventricular administration of interferon-gamma modifies locomotor activity in the golden hamster
    Verónica I Boggio
    Departamento de Fisiologia, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina
    Neurosignals 12:89-94. 2003
    ..One explanation could be the presence of IFN-gamma receptor in the rat suprachiasmatic nucleus, supporting a direct effect on the central oscillator. However, another hypothesis could not be ruled out...
  43. ncbi request reprint Melatonin role in experimental arthritis
    Daniel P Cardinali
    Departamento de Fisiologia, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina
    Curr Drug Targets Immune Endocr Metabol Disord 4:1-10. 2004
    ....
  44. ncbi request reprint Vascular reactivity in diabetic rats: effect of melatonin
    Carlos F Reyes-Toso
    Departmento de Fisiologia, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina
    J Pineal Res 33:81-6. 2002
    ....
  45. ncbi request reprint Nighttime changes in norepinephrine and melatonin content and serotonin turnover in pineal glands of young and old rats injected with Freund's adjuvant
    Pilar Cano
    Departamento de Bioquimica y Biologia Molecular III, Universidad de Buenos Aires, Buenos Aires, Argentina
    Neuro Endocrinol Lett 23:49-53. 2002
    ..This study was performed to search for changes in rat pineal function attributed to age and immunization with Freund's adjuvant...
  46. ncbi request reprint Circadian disorganization in experimental arthritis
    Daniel P Cardinali
    Departamento de Fisiologia, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina
    Neurosignals 12:267-82. 2003
    ..Some pinealectomy-induced immune changes in arthritic rats were also prevented by physiological concentrations of melatonin. Melatonin may play the role of an 'internal synchronizer' for the immune system...
  47. ncbi request reprint Melatonin effect on bone metabolism in rats treated with methylprednisolone
    Marta G Ladizesky
    Departamento de Fisiologia, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina
    J Pineal Res 40:297-304. 2006
    ..The results are compatible with the view that low doses of methylprednisolone or melatonin decrease bone resorption and have a bone-protecting effect...
  48. ncbi request reprint Low urinary 6-sulfatoxymelatonin levels in patients with severe congestive heart failure
    Luis Girotti
    Division Cardiologia, Hospital Ramos Mejia, Buenos Aires, Argentina
    Endocrine 22:245-8. 2003
    ..To assess urinary 6-sulfatoxymelatonin excretion in patients admitted to the hospital because of congestive heart failure (CHF)...
  49. pmc Therapeutic application of melatonin in mild cognitive impairment
    Daniel P Cardinali
    Departamento de Docencia e Investigación, Facultad de Ciencias Medicas, Pontificia Universidad Católica Argentina Buenos Aires, Argentina
    Am J Neurodegener Dis 1:280-91. 2012
    ..8% in the melatonin group received benzodiazepines vs. 62.8% in the non-melatonin group. The results further support that melatonin can be a useful add-on drug for treating MCI in a clinic environment...
  50. doi request reprint Cardiac autonomic activity predicts dominance in verbal over spatial reasoning tasks: results from a preliminary study
    Juan I Solernó
    Departamento de Fisiologia, Facultad de Medicina, Universidad de Buenos Aires, Argentina
    Auton Neurosci 167:78-80. 2012
    ..The results showed that a better relative performance in verbal over spatial reasoning tasks was associated with vagal prevalence in normal subjects...
  51. ncbi request reprint Brief review: diurnal rhythms, obesity and educational achievement in South american cultures
    Daniel Perez-Chada
    Pulmonary Division and Internal Medicine Department, Hospital Universitario Austral, Buenos Aires, Argentina
    Int J Neurosci 119:1091-104. 2009
    ..The theoretical basis of this relationship is discussed. Several studies investigating the relationships between obesity, sleep disturbance, and a number of important negative outcomes are reviewed...
  52. pmc Attitudes towards treatment among patients suffering from sleep disorders. A Latin American survey
    Margarita Blanco
    Neurofisiología Clínica y Medicina del Sueño, Centro Neurologico, Hospital Frances, Buenos Aires, Argentina
    BMC Fam Pract 4:17. 2003
    ..Although sleep disorders are common, they frequently remain unnoticed by the general practitioner. Few data are available about the willingness and reasons of patients with sleep disturbances to seek for medical assistance...
  53. pmc Clinical aspects of melatonin intervention in Alzheimer's disease progression
    Daniel P Cardinali
    Departamento de Docencia e Investigación, Facultad de Ciencias Medicas, Pontificia Universidad Católica Argentina, Buenos Aires, Argentina
    Curr Neuropharmacol 8:218-27. 2010
    ..In the case of AD, larger randomized controlled trials are necessary to yield evidence of effectiveness (i.e. clinical and subjective relevance) before melatonin´s use can be advocated...
  54. ncbi request reprint Depressive symptoms are related to decreased low-frequency heart rate variability in older adults with decompensated heart failure
    Salvador M Guinjoan
    Fundacion para la Lucha contra las Enfermedades Neurologicas de la Infancia, Universidad de Buenos Aires, Buenos Aires, Argentina
    Neuropsychobiology 55:219-24. 2007
    ..Depression is often found to result in autonomic dysfunction which, if present in heart failure, might help explain worsened outcomes...
  55. ncbi request reprint A multifactorial approach employing melatonin to accelerate resynchronization of sleep-wake cycle after a 12 time-zone westerly transmeridian flight in elite soccer athletes
    Daniel P Cardinali
    Departamento de Fisiologia, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina
    J Pineal Res 32:41-6. 2002
    ..The results indicate that the combination of melatonin treatment, an appropriate environmental light schedule and timely applied physical exercise can be useful to help elite athletes to overcome the consequences of jet lag...