Francesco Cappello

Summary

Publications

  1. ncbi request reprint Protective role of the complement regulatory protein human CD-55 in cardiac xenograft: a descriptive study and a revision of the literature
    F Cappello
    Human Anatomy Section, Department of Experimental Medicine, University of Palermo, Italy
    Histol Histopathol 17:1085-94. 2002
  2. ncbi request reprint Immunohistochemical evaluation of PCNA, p53, HSP60, HSP10 and MUC-2 presence and expression in prostate carcinogenesis
    Francesco Cappello
    Human Anatomy Section, Department of Experimental Medicine, Institute of Pathological Anatomy, University of Palermo, Italy
    Anticancer Res 23:1325-31. 2003
  3. ncbi request reprint Hsp60 and human aging: Les liaisons dangereuses
    Francesco Cappello
    Department of Experimental Biomedicine and Clinical Neurosciences, Human Anatomy Section, Emerico Luna, Via del Vespro 129, 90127 Palermo, Italy
    Front Biosci (Landmark Ed) 18:626-37. 2013
  4. pmc The odyssey of Hsp60 from tumor cells to other destinations includes plasma membrane-associated stages and Golgi and exosomal protein-trafficking modalities
    Claudia Campanella
    Dipartimento BIONEC, Sezione di Anatomia Umana, University of Palermo, Palermo, Italy
    PLoS ONE 7:e42008. 2012
  5. pmc Hsp60 is actively secreted by human tumor cells
    Anna M Merendino
    Dipartimento di Biomedicina Sperimentale e Neuroscienze Cliniche, Universita degli Studi di Palermo, Palermo, Italy
    PLoS ONE 5:e9247. 2010
  6. pmc Is CD1a involved in antitumour immune responses during carcinogenesis?
    F Cappello
    Br J Cancer 90:938; author reply 939. 2004
  7. ncbi request reprint Giovanni Filippo Ingrassia: A five-hundred year-long lesson
    Francesco Cappello
    Dipartimento di Biomedicina Sperimentale e Neuroscienze Cliniche, Universita degli Studi di Palermo, Palermo, Italy
    Clin Anat 23:743-9. 2010
  8. pmc Convergent sets of data from in vivo and in vitro methods point to an active role of Hsp60 in chronic obstructive pulmonary disease pathogenesis
    Francesco Cappello
    Dipartimento di Biomedicina Sperimentale e Neuroscienze Cliniche, Sezione di Anatomia Umana, Universita degli Studi di Palermo, Palermo, Italy
    PLoS ONE 6:e28200. 2011
  9. pmc Hsp10, Hsp70, and Hsp90 immunohistochemical levels change in ulcerative colitis after therapy
    G Tomasello
    Dipartimento di Discipline Chirurgiche ed Oncologiche, Universita di Palermo, Italy
    Eur J Histochem 55:e38. 2011
  10. pmc Molecular oncology focus - is carcinogenesis a 'mitochondriopathy'?
    Anna M Czarnecka
    Laboratory of Molecular Oncology, Department of Oncology, Military Institute of the Health Services, Warsaw, Poland
    J Biomed Sci 17:31. 2010

Detail Information

Publications77

  1. ncbi request reprint Protective role of the complement regulatory protein human CD-55 in cardiac xenograft: a descriptive study and a revision of the literature
    F Cappello
    Human Anatomy Section, Department of Experimental Medicine, University of Palermo, Italy
    Histol Histopathol 17:1085-94. 2002
    ..In conclusion, we encourage the use of new sources of transgenic animals, pointing out the importance of morphological analysis in evaluation of xenograft...
  2. ncbi request reprint Immunohistochemical evaluation of PCNA, p53, HSP60, HSP10 and MUC-2 presence and expression in prostate carcinogenesis
    Francesco Cappello
    Human Anatomy Section, Department of Experimental Medicine, Institute of Pathological Anatomy, University of Palermo, Italy
    Anticancer Res 23:1325-31. 2003
    ..The study of the expression of different biological markers in non-neoplastic, pre-neoplastic and neoplastic lesions of prostate could help to better understand their role in carcinogenesis and to find new diagnostic and prognostic tools...
  3. ncbi request reprint Hsp60 and human aging: Les liaisons dangereuses
    Francesco Cappello
    Department of Experimental Biomedicine and Clinical Neurosciences, Human Anatomy Section, Emerico Luna, Via del Vespro 129, 90127 Palermo, Italy
    Front Biosci (Landmark Ed) 18:626-37. 2013
    ....
  4. pmc The odyssey of Hsp60 from tumor cells to other destinations includes plasma membrane-associated stages and Golgi and exosomal protein-trafficking modalities
    Claudia Campanella
    Dipartimento BIONEC, Sezione di Anatomia Umana, University of Palermo, Palermo, Italy
    PLoS ONE 7:e42008. 2012
    ..g., by the Golgi. We addressed these issues in the work presented here...
  5. pmc Hsp60 is actively secreted by human tumor cells
    Anna M Merendino
    Dipartimento di Biomedicina Sperimentale e Neuroscienze Cliniche, Universita degli Studi di Palermo, Palermo, Italy
    PLoS ONE 5:e9247. 2010
    ..These questions are particularly relevant for cancer biology since it is believed that extracellular chaperones, like Hsp70, may play an active role in tumor growth and dissemination...
  6. pmc Is CD1a involved in antitumour immune responses during carcinogenesis?
    F Cappello
    Br J Cancer 90:938; author reply 939. 2004
  7. ncbi request reprint Giovanni Filippo Ingrassia: A five-hundred year-long lesson
    Francesco Cappello
    Dipartimento di Biomedicina Sperimentale e Neuroscienze Cliniche, Universita degli Studi di Palermo, Palermo, Italy
    Clin Anat 23:743-9. 2010
    ..He is remembered for his intellectual authority and honesty. Five-hundred years after his birth, his teaching is still alive. In this article, we survey the life and contribution of this pioneer of early anatomical study...
  8. pmc Convergent sets of data from in vivo and in vitro methods point to an active role of Hsp60 in chronic obstructive pulmonary disease pathogenesis
    Francesco Cappello
    Dipartimento di Biomedicina Sperimentale e Neuroscienze Cliniche, Sezione di Anatomia Umana, Universita degli Studi di Palermo, Palermo, Italy
    PLoS ONE 6:e28200. 2011
    ..Here, we report results showing participation of Hsp60 in the pathogenesis of chronic obstructive pulmonary diseases (COPD), as indicated by data from both in vivo and in vitro analyses...
  9. pmc Hsp10, Hsp70, and Hsp90 immunohistochemical levels change in ulcerative colitis after therapy
    G Tomasello
    Dipartimento di Discipline Chirurgiche ed Oncologiche, Universita di Palermo, Italy
    Eur J Histochem 55:e38. 2011
    ..g., to monitor response to treatment at the histological level)...
  10. pmc Molecular oncology focus - is carcinogenesis a 'mitochondriopathy'?
    Anna M Czarnecka
    Laboratory of Molecular Oncology, Department of Oncology, Military Institute of the Health Services, Warsaw, Poland
    J Biomed Sci 17:31. 2010
    ....
  11. pmc Primitive Neuroectodermal Tumor (PNET) of the kidney: a case report
    Giorgio Pomara
    Department of Surgery, Urology Section S, Chiara Hospital, University of Pisa, Pisa, Italy
    BMC Cancer 4:3. 2004
    ..In our case, a radical nephrectomy with lymphadenectomy was performed and there was no residual or recurrent tumour at 24-month follow-up...
  12. ncbi request reprint Hsp60 expression, new locations, functions and perspectives for cancer diagnosis and therapy
    Francesco Cappello
    Department of Experimental Medicine, University of Palermo, Palermo, Italy
    Cancer Biol Ther 7:801-9. 2008
    ....
  13. pmc CD1a expression by Barrett's metaplasia of gastric type may help to predict its evolution towards cancer
    F Cappello
    Human Anatomy Section, Department of Experimental Medicine, University of Palermo, Via alla Falconara 120, 90136 Palermo, Italy
    Br J Cancer 92:888-90. 2005
    ..Our data address that CD1a may be a novel biomarker for BM and that its expression may help to predict the prognosis of this pathology...
  14. doi request reprint Immunohistochemistry of human Hsp60 in health and disease: from autoimmunity to cancer
    Francesco Cappello
    Department of Experimental Biomedicine and Clinical Neuroscience, University of Palermo, Palermo, Italy
    Methods Mol Biol 787:245-54. 2011
    ....
  15. ncbi request reprint Immunopositivity of heat shock protein 60 as a biomarker of bronchial carcinogenesis
    Francesco Cappello
    Human Anatomy Section, University of Palermo, Palermo, Italy
    Lancet Oncol 6:816. 2005
  16. pmc The expression of HSP60 and HSP10 in large bowel carcinomas with lymph node metastase
    Francesco Cappello
    Sezione di Anatomia Umana, Dipartimento di Medicina Sperimentale, Universita degli Studi di Palermo, Italy
    BMC Cancer 5:139. 2005
    ..The objective of the present study was to evaluate the presence and expression of HSP60 and HSP10 in a series of large bowel carcinomas and locoregional lymph nodes with and without metastases...
  17. ncbi request reprint Synovial sarcoma and malignant mesothelioma of the pleura: review, differential diagnosis and possible role of apoptosis
    F Cappello
    Institute of Pathological Anatomy, University of Palermo, Italy
    Pathology 33:142-8. 2001
    ..The role of apoptosis in the pathogenesis of these tumours needs to be explored with a much larger series...
  18. ncbi request reprint The value of immunohistochemical research on PCNA, p53 and heat shock proteins in prostate cancer management: a review
    F Cappello
    Department of Experimental Medicine, Human Anatomy Section, Palermo, Italy
    Eur J Histochem 50:25-34. 2006
    ..We will also discuss the possible functional interactions of these molecules in both dysplastic and neoplastic cells...
  19. pmc Chlamydia trachomatis infection and anti-Hsp60 immunity: the two sides of the coin
    Francesco Cappello
    Dipartimento di Medicina Sperimentale, Sezione di Anatomia Umana Emerico Luna, Universita degli Studi di Palermo, Palermo, Italy
    PLoS Pathog 5:e1000552. 2009
    ..The opposite side of the coin is that pre-tumor and tumor cells with sf-Hsp60 can be destroyed with participation of the anti-Hsp60 antibody, thus stopping cancer progression before it is even noticed by the patient or physician...
  20. ncbi request reprint Hsp60 and Hspl0 as antitumor molecular agents
    Francesco Cappello
    Department of Experimental Medicine, University of Palermo, Palermo, Italy
    Cancer Biol Ther 6:487-9. 2007
    ..There is also evidence showing that Hsp60 and Hsp10 can be used as therapeutic agents, for example in rheumatoid arthritis. In view of these findings we want now to call attention to the potential of Hsp60 and Hsp10 in cancer therapy...
  21. ncbi request reprint Mature teratoma of the uterine corpus with thyroid differentiation
    F Cappello
    Institute of Pathological Anatomy, University of Palermo, Palermo, Italy
    Pathol Int 50:546-8. 2000
    ..Macroscopically, a colloid-hemorrhagic-looking nodule was present. Histologic and immunohistochemical studies showed that this tumor was a small thyroid mass. Key words:,..
  22. ncbi request reprint HSP10 selective preference for myeloid and megakaryocytic precursors in normal human bone marrow
    F Cappello
    Human Anatomy Section, Department of Experimental Medicine, University of Palermo, Italy
    Eur J Histochem 48:261-5. 2004
    ..The present data emphasize the role of HSP10 during cellular homeostasis and encourage further investigations in this field...
  23. ncbi request reprint Poorly differentiated synovial sarcoma: a case report
    F Cappello
    Institute of Pathological Anatomy, University of Palermo, Italy
    Pathol Oncol Res 7:63-6. 2001
    ..These data also suggest that the reduction of apoptotic phenomena in poorly differentiated synovial sarcoma could be considered one of the major mechanisms of tumoral growth...
  24. ncbi request reprint Biological aggressiveness evaluation in prostate carcinomas:immunohistochemical analysis of PCNA and p53 in a series of Gleason 6 (3+3) adenocarcinomas
    F Cappello
    Human Anatomy Section, Department of Experimental Medicine, University of Palermo, Italy
    Eur J Histochem 47:129-32. 2003
    ..Moreover, we found a linear relationship between the increase of PCNA and the accumulation of mutated p53; this datum could confirm the hypothesis that p53 mutation is a late event in prostate carcinogenesis...
  25. ncbi request reprint 60KDa chaperonin (HSP60) is over-expressed during colorectal carcinogenesis
    F Cappello
    Human Anatomy Section, Department of Experimental Medicine, University of Palermo Italy
    Eur J Histochem 47:105-10. 2003
    ..We suspect that HSP60 plays a different role in colorectal carcinogenesis with respect to that in normal cells, which foresees its possible use as diagnostic and prognostic tools...
  26. ncbi request reprint Ten kilodalton heat shock protein (HSP10) is overexpressed during carcinogenesis of large bowel and uterine exocervix
    Francesco Cappello
    Department of Experimental Medicine, University of Palermo, Via alla Falconara 120, Palermo 90136, Italy
    Cancer Lett 196:35-41. 2003
    ..These results could stimulate further studies on the pathogenetic role of these proteins during the carcinogenesis as well as their use as diagnostic and prognostic tools in oncology...
  27. ncbi request reprint CD1a: a novel biomarker for Barrett's metaplasia?
    Francesco Cappello
    Lancet Oncol 4:497. 2003
  28. ncbi request reprint Hsp60: molecular anatomy and role in colorectal cancer diagnosis and treatment
    Francesco Cappello
    Department of Experimental Biomedicine and Clinical Neurosciences, University of Palermo, Palermo, Italy
    Front Biosci (Schol Ed) 3:341-51. 2011
    ..Some of these issues pertinent to colorectal cancer (CRC) are discussed in this article...
  29. ncbi request reprint Defective apoptosis and tumorigenesis: role of p53 mutation and Fas/FasL system dysregulation
    F Cappello
    Sezione di Anatomia Umana, Dipartimento di Medicina Sperimentale, Universita di Palermo, Italy
    Eur J Histochem 46:199-208. 2002
    ..In this review, we focused on how they can determine defective apoptosis, one of the causes of tumorigenesis and tumor progression. The importance of this knowledge lies in the new perspectives that gene therapy can offer to cure cancer...
  30. doi request reprint Changes in immunohistochemical levels and subcellular localization after therapy and correlation and colocalization with CD68 suggest a pathogenetic role of Hsp60 in ulcerative colitis
    Giovanni Tomasello
    Dipartimento di Chirurgia Generale, d Urgenza e Trapianti d Organo, Università degli Studi di Palermo Istituto Euro Mediterraneo di Scienza e Tecnologia IEMEST, Palermo, Italy
    Appl Immunohistochem Mol Morphol 19:552-61. 2011
    ..Our data suggest that Hsp60 is an active player in pathogenesis of UC and it can be hypothesized that the chaperonin is responsible, at least in part, for initiation and maintenance of disease...
  31. ncbi request reprint New emerging potentials for human Wharton's jelly mesenchymal stem cells: immunological features and hepatocyte-like differentiative capacity
    Rita Anzalone
    Sezione di Anatomia Umana, Dipartimento di Medicina Sperimentale, Universita degli Studi di Palermo, Italy
    Stem Cells Dev 19:423-38. 2010
    ..This, together with their in vitro proliferative potential and their immunoregulatory features, renders these cells extremely promising for regenerative medicine applications in different pathological settings...
  32. doi request reprint Human Hsp10 and Early Pregnancy Factor (EPF) and their relationship and involvement in cancer and immunity: current knowledge and perspectives
    Simona Corrao
    Dipartimento di Medicina Sperimentale, Universita degli Studi di Palermo, Via del Vespro 129, 90127, Palermo, Italy
    Life Sci 86:145-52. 2010
    ..In this article, we present an overview of various aspects of Hsp10 and EPF as they participate in physiological and pathological processes such as the antitumor response and autoimmune diseases...
  33. ncbi request reprint Hsp10: anatomic distribution, functions, and involvement in human disease
    Sabrina David
    Department of Experimental Biomedicine and Clinical Neuroscience, Section of Human Anatomy, University of Palermo, Italy
    Front Biosci (Elite Ed) 5:768-78. 2013
    ..Hsp10 may also be found in the extracellular space and in the bloodstream, with a possible immunomodulatory activity. This minireview focuses on some studies to date on the involvement of Hsp10 in human disease pathogenesis...
  34. doi request reprint Isolation and characterization of CD276+/HLA-E+ human subendocardial mesenchymal stem cells from chronic heart failure patients: analysis of differentiative potential and immunomodulatory markers expression
    Rita Anzalone
    Sezione di Anatomia Umana, Dipartimento di Biomedicina Sperimentale e Neuroscienze Cliniche BioNeC, Universita degli Studi di Palermo, Palermo, Italy
    Stem Cells Dev 22:1-17. 2013
    ..The use of heart-derived MSCs to promote in-organ repair or as a cellular source for cardiomyoplasty is a fascinating and challenging task, which deserves further research efforts...
  35. ncbi request reprint Hsp60 and Hsp10 down-regulation predicts bronchial epithelial carcinogenesis in smokers with chronic obstructive pulmonary disease
    Francesco Cappello
    Institute of Human Anatomy, University of Palermo, Palermo, Italy
    Cancer 107:2417-24. 2006
    ....
  36. doi request reprint OPLA scaffold, collagen I, and horse serum induce an higher degree of myogenic differentiation of adult rat cardiac stem cells
    Valentina Di Felice
    Department of Experimental Medicine, Human Anatomy Section, University of Palermo, Palermo, Italy
    J Cell Physiol 221:729-39. 2009
    ..These experiments demonstrated an important model for the study of the biology of CSCs and the biochemical pathways that lead to myocardial differentiation. The results pave the way for a new surgical approach...
  37. ncbi request reprint Role of endothelial cell stress in the pathogenesis of chronic heart failure
    Rita Anzalone
    Human Anatomy Section, Department of Experimental Medicine, University of Palermo, Via del Vespro 129, 90127 Palermo, Italy
    Front Biosci (Landmark Ed) 14:2238-47. 2009
    ..Understanding the molecular mechanisms involved in these stress responses in endothelium will lead to better therapeutic strategies for oxidative stress-driven cardiovascular diseases...
  38. ncbi request reprint HSP-molecular chaperones in cancer biogenesis and tumor therapy: an overview
    Francesca Rappa
    Department of Experimental Medicine and Clinical Neuroscience, University of Palermo, Palermo, Italy Via del Vespro 129, 90127, Palermo, Italy
    Anticancer Res 32:5139-50. 2012
    ....
  39. doi request reprint Isolation and characterization of Oct-4+/HLA-G+ mesenchymal stem cells from human umbilical cord matrix: differentiation potential and detection of new markers
    Giampiero La Rocca
    Sezione di Anatomia Umana, Dipartimento di Medicina Sperimentale, Universita degli Studi di Palermo, Via del Vespro 129, 90127, Palermo, Italy
    Histochem Cell Biol 131:267-82. 2009
    ....
  40. doi request reprint BRAF(V600E) mutation influences hypoxia-inducible factor-1alpha expression levels in papillary thyroid cancer
    Monica Zerilli
    Department of Human Pathology, University of Palermo, Palermo, Italy
    Mod Pathol 23:1052-60. 2010
    ..Our results suggest that hypoxia-inducible factor-1alpha is expressed in papillary thyroid carcinomas and is regulated not only by hypoxia but also by BRAF(V600E)-mediated signaling pathway...
  41. pmc Hsp60 and Hsp10 increase in colon mucosa of Crohn’s disease and ulcerative colitis
    Vito Rodolico
    Dipartimento di Patologia Umana, Universita degli Studi di Palermo, Palermo, Italy
    Cell Stress Chaperones 15:877-84. 2010
    ....
  42. pmc Cigarette smoke exposure inhibits extracellular MMP-2 (gelatinase A) activity in human lung fibroblasts
    Giampiero La Rocca
    Sezione di Anatomia Umana, Dipartimento di Medicina Sperimentale, Universita degli Studi di Palermo, Via del Vespro 129, 90127 Palermo, Italy
    Respir Res 8:23. 2007
    ..Multiple reports linked gelatinase deregulation and overexpression to the development of inflammatory chronic lung diseases such as COPD...
  43. ncbi request reprint HSP90 and eNOS partially co-localize and change cellular localization in relation to different ECM components in 2D and 3D cultures of adult rat cardiomyocytes
    Valentina Di Felice
    Human Anatomy Section E Luna, Department of Experimental Medicine, University of Palermo, Via del Vespro 129, 90127 Palermo, Italy
    Biol Cell 99:689-99. 2007
    ....
  44. ncbi request reprint Senescence-associated HSP60 expression in normal human skin fibroblasts
    Valentina Di Felice
    Dipartimento di Medicina Sperimentale, Sezione di Anatomia Umana Emerico Luna, Universita di Palermo, Palermo, Italy
    Anat Rec A Discov Mol Cell Evol Biol 284:446-53. 2005
    ..An increase in HSP60 protein amount is associated with a cell cycle slow-down and it may have a role in cell cycle progression...
  45. pmc Heat-shock protein 60 kDa and atherogenic dyslipidemia in patients with untreated mild periodontitis: a pilot study
    Manfredi Rizzo
    Department of Internal Medicine and Medical Specialties, University of Palermo, Palermo, Italy
    Cell Stress Chaperones 17:399-407. 2012
    ..Thus, the road is open to investigate the potential value of elevated levels of circulating Hsp60 as predictor of risk for cardiovascular disease when associated to dyslipidemia in periodontitis patients...
  46. ncbi request reprint CD1a and antitumour immune response
    Giampiero La Rocca
    Human Anatomy Section, Department of Experimental Medicine, University of Palermo, Via del Vespro 129, 90127 Palermo, Italy
    Immunol Lett 95:1-4. 2004
    ..Moreover, the strong correlation between the lack of CD1a+ cells and the malignant evolution of the lesion may indicate a possible role of non-professional APCs in mediating and/or potentiating immune responses to tumours...
  47. doi request reprint Different immunophenotypical apoptotic profiles characterise megakaryocytes of essential thrombocythaemia and primary myelofibrosis
    A M Florena
    Dipartimento di Patologia Umana, Universita degli Studi di Palermo, Italy
    J Clin Pathol 62:331-8. 2009
    ..The aim of this study was to investigate the apoptotic profile of ET and PMF MKCs in order to further characterise the biology of these disorders...
  48. ncbi request reprint Heat shock protein-60 and risk for cardiovascular disease
    Manfredi Rizzo
    Department of Internal Medicine and Medical Specialties, University of Palermo, Palermo, Italy
    Curr Pharm Des 17:3662-8. 2011
    ..The data not only indicate a pathogenic role for HSP60 but also its potential as a biomarker with applications for diagnosis, assessing prognosis and response to treatment, as well as for preventing and treating CVD...
  49. doi request reprint The molecular anatomy of human Hsp60 and its similarity with that of bacterial orthologs and acetylcholine receptor reveal a potential pathogenetic role of anti-chaperonin immunity in myasthenia gravis
    Antonella Marino Gammazza
    Dipartimento di Biomedicina Sperimentale e Neuroscienze Cliniche, Universita degli Studi di Palermo, Palermo, Italy
    Cell Mol Neurobiol 32:943-7. 2012
    ..The structural data indicate that AChRα1 antibodies, implicated in the pathogenesis of myasthenia gravis, could very well be elicited and/or maintained by self- and/or bacterial Hsp60...
  50. doi request reprint Oxidative stress induces myeloperoxidase expression in endocardial endothelial cells from patients with chronic heart failure
    Giampiero La Rocca
    Sezione di Anatomia Umana, Dipto di Medicina Sperimentale, Universita degli Studi di Palermo, Palermo, Italy
    Basic Res Cardiol 104:307-20. 2009
    ..The results also highlight the notion that endothelium is not only a target but also a key player in oxidative-driven cardiovascular stress...
  51. ncbi request reprint Comparative analysis of hsp10 and hsp90 expression in healthy mucosa and adenocarcinoma of the large bowel
    Francesca Rappa
    Department of Experimental Biomedicine and Clinical Neuroscience, Section of Human Anatomy, University of Palermo, Palermo, Italy Euro Mediterranean Institute of Science and Technology IEMEST, Palermo, Italy
    Anticancer Res 34:4153-9. 2014
    ..Hsp90 stabilizes a range of "client" proteins involved in cell signaling. The present study evaluated the expression levels of Hsp10 and Hsp90 in normal mucosa and adenocarcinoma samples of human large bowel...
  52. ncbi request reprint Gut microbiota imbalance and chaperoning system malfunction are central to ulcerative colitis pathogenesis and can be counteracted with specifically designed probiotics: a working hypothesis
    Maurizio Bellavia
    Department of Surgical and Oncological Sciences, University of Palermo, Via del Vespro 129, 90127, Palermo, Italy
    Med Microbiol Immunol 202:393-406. 2013
    ..Microbiota fingerprinting ought to include molecular biology techniques for sequencing highly conserved DNA, e.g., genes encoding 16S RNA, for species identification and, in addition, quantification of each relevant microbe. ..
  53. ncbi request reprint Cardiac stem cell research: an elephant in the room?
    Valentina Di Felice
    Human Anatomy Section, Department of Experimental Medicine, University of Palermo, Via del Vespro 129, Palermo, Italy
    Anat Rec (Hoboken) 292:449-54. 2009
    ....
  54. ncbi request reprint Increased expression of transketolase-like-1 in papillary thyroid carcinomas smaller than 1.5 cm in diameter is associated with lymph-node metastases
    Monica Zerilli
    Department of Human Pathology, University of Palermo, Palermo, Italy
    Cancer 113:936-44. 2008
    ..A mutated transketolase transcript (TKTL1) has been found up-regulated in different human malignancies, and strong TKTL1 protein expression has been associated with aggressiveness and poor patient survival in several epithelial cancers...
  55. pmc Elevated blood Hsp60, its structural similarities and cross-reactivity with thyroid molecules, and its presence on the plasma membrane of oncocytes point to the chaperonin as an immunopathogenic factor in Hashimoto's thyroiditis
    Antonella Marino Gammazza
    Department of Experimental Biomedicine and Clinical Neurosciences, University of Palermo, Palermo, Italy
    Cell Stress Chaperones 19:343-53. 2014
    ..All together, these results led us to hypothesize that Hsp60 may be an active player in HT pathogenesis via an antibody-mediated immune mechanism. ..
  56. doi request reprint Hsp60 chaperonopathies and chaperonotherapy: targets and agents
    Francesco Cappello
    Euro Mediterranean Institute of Science and Technology IEMEST, Palermo, Italy
    Expert Opin Ther Targets 18:185-208. 2014
    ..Hsp60 (Cpn60) assembles into a tetradecamer that interacts with the co-chaperonin Hsp10 (Cpn10) to assist client polypeptides to fold, but it also has other roles, including participation in pathogenic mechanisms...
  57. ncbi request reprint Chaperonopathies and chaperonotherapy. Hsp60 as therapeutic target in cancer: potential benefits and risks
    Francesco Cappello
    Dipartimento di Biomedicina Sperimentale e Neuroscienze Cliniche, Sezione di Anatomia Umana, University of Palermo, Palermo, Italy
    Curr Pharm Des 19:452-7. 2013
    ....
  58. ncbi request reprint Presence and interaction in tissues of atrial natriuretic peptide, oxytocin and vasopressin: new insights
    Biagio Valentino
    Dipartimento di Biomedicina Sperimentale e Neuroscienze Cliniche, Sezione di Anatomia Umana, University of Palermo, Italy
    Ital J Anat Embryol 115:159-65. 2010
    ..In this minireview we summarise some of the main results that open new scenarios in the comprehension of the biologic activities of these peptides and allow to postulate a role for them as diagnostic tools...
  59. doi request reprint Hsp60 and heme oxygenase-1 (Hsp32) in acute myocardial infarction
    Giuseppina Novo
    Department of Internal Medicine, Cardiovascular, and Nephrourological Diseases, University of Palermo, Palermo, Italy
    Transl Res 157:285-92. 2011
    ..The results clear the way for subsequent investigation on the pathogenetic role and clinical significance of Hsp60 and HO-1 in AMI...
  60. ncbi request reprint Hsp60, a novel target for antitumor therapy: structure-function features and prospective drugs design
    Andrea Pace
    Dipartimento di Scienze e Tecnologie Molecolari e Biomolecolari STEMBIO Università degli Studi di Palermo, Palermo, Italy
    Curr Pharm Des 19:2757-64. 2013
    ....
  61. pmc Immunopositivity for histone macroH2A1 isoforms marks steatosis-associated hepatocellular carcinoma
    Francesca Rappa
    Department of Experimental Biomedicine and Clinical Neurosciences, Section of Human Anatomy, University of Palermo, Palermo, Italy
    PLoS ONE 8:e54458. 2013
    ..1 and macroH2A1.2. These isoforms have been shown to predict lung and colon cancer recurrence but to our knowledge, their role in fatty-liver associated HCC has not been investigated previously...
  62. doi request reprint Glucagon-like peptide-2 and mouse intestinal adaptation to a high-fat diet
    Sara Baldassano
    Laboratorio di Fisiologia generale, Dipartimento di Scienze e Tecnologie Molecolari e Biomolecolari STEMBIO, Universita di Palermo, 90128 Palermo, Italy
    J Endocrinol 217:11-20. 2013
    ..This study provides the first experimental evidence for a role of endogenous GLP2 in the intestinal adaptation to HFD in obese mice and for a dysregulation of the GLP2/GLP2R system after a prolonged HFD...
  63. ncbi request reprint Human recombinant vasostatin-1 may interfere with cell-extracellular matrix interactions
    Valentina Di Felice
    Human Anatomy Section, Department of Experimental Medicine, University of Palermo, Italy
    Ann N Y Acad Sci 1090:305-10. 2006
    ..On the whole, these data suggest that VS-1 does not have a classic receptor on the membrane but that integrins may represent a nonconventional VS-1 receptor modulating eNOS signaling pathway...
  64. ncbi request reprint Gastric and gingival localization of mucosa-associated lymphoid tissue (MALT) lymphoma. An immunohistochemical, virological and clinical case report
    V Margiotta
    Department of Oral Medicine, University of Palermo, Italy
    J Periodontol 70:914-8. 1999
    ..The pathogenetic mechanisms of NHL in oral MALT and the diagnosis and treatment are discussed...
  65. ncbi request reprint Splenectomy influences bone marrow infiltration in patients with splenic marginal zone cell lymphoma with or without villous lymphocytes
    V Franco
    Istituto di Anatomia e Istologia Patologica, Universita di Palermo, Palermo, Italy
    Cancer 91:294-301. 2001
    ..Splenectomy is the reported treatment of choice for these patients. The objective of this study was to evaluate the effects of splenectomy on patients with BM lymphomatous infiltration...
  66. ncbi request reprint Adrenal myelolipoma associated with adenoma
    Francesca Manassero
    Department of Urology, Pisa University, Pisa, Italy
    Int J Urol 11:326-8. 2004
    ..In conclusion, the 8.5 cm myelolipoma in our case is the largest compared with the three previously reported ones...
  67. ncbi request reprint Megakaryocytic features useful for the diagnosis of myeloproliferative disorders can be obtained by a novel unsupervised software analysis
    C Tripodo
    Istituto di Anatomia Patologica, Universita degli Studi di Palermo, Italy
    Histol Histopathol 21:813-21. 2006
    ..The method proposed should be considered as a fast preprocessing tool for the diagnostic phase and its use can be extended to solve different object recognition problems...
  68. pmc Endurance exercise and conjugated linoleic acid (CLA) supplementation up-regulate CYP17A1 and stimulate testosterone biosynthesis
    Rosario Barone
    Department of Experimental Biomedicine and Clinical Neurosciences BioNeC, University of Palermo, Palermo, Italy
    PLoS ONE 8:e79686. 2013
    ..Therefore, CLA-associated physical activity may be used for its steroidogenic property in different fields, such as alimentary industry, human reproductive medicine, sport science, and anti-muscle wasting. ..
  69. pmc Hypoxia inducible factor-1 alpha expression is increased in infected positive HPV16 DNA oral squamous cell carcinoma and positively associated with HPV16 E7 oncoprotein
    Vito Rodolico
    Department of Sciences for Health Promotion, Section of Anatomic Pathology, University of Palermo, Palermo, Italy
    Infect Agent Cancer 6:18. 2011
    ..abstract:..
  70. ncbi request reprint Atrial natriuretic factor, but not oxytocin, is present in atherosclerotic plaques of human common carotid arteries
    Gaetano La Barbera
    Unità Operativa Complessa di Chirurgia Vascolare, ARNAS Civico e Benfratelli, Palermo, Italy
    Ital J Anat Embryol 114:129-36. 2009
    ....
  71. ncbi request reprint Response to low-dose oral methotrexate and prednisone in two patients with angio-immunoblastic lymphadenopathy-type T-cell lymphoma
    G Quintini
    Divisione di Ematologia con Trapianto di Midollo, Universita di Palermo, Italy
    Hematol J 2:393-5. 2001
    ..AILD-type T-cell lymphoma is characterized by very poor prognosis in most patients and the response rate to conventional chemotherapy is unsatisfactory...
  72. ncbi request reprint Expression of 60-kD heat shock protein increases during carcinogenesis in the uterine exocervix
    F Cappello
    Department of Experimental Medicine, University of Palermo, Palermo, Italy
    Pathobiology 70:83-8. 2002
    ..The aim of the present study was to determine the presence and expression of the 60-kD heat shock protein (HSP60) in the dysplasia-carcinoma sequence in the uterine exocervix and to evaluate its diagnostic and prognostic significance...
  73. pmc Carcinosarcoma of monoclonal origin arising in a dermoid cyst of ovary: a case report
    Daniela Cabibi
    Istituto di Anatomia Patologica, Facolta di Medicina, Universita degli Studi di Palermo, Italy
    BMC Cancer 6:47. 2006
    ..Transformation of a cystic benign teratoma of the ovary into a "carcinosarcoma" has very rarely been reported and its histogenetic origin is still debated...
  74. ncbi request reprint Immunophenotypic profile and role of adhesion molecules in splenic marginal zone lymphoma with bone marrow involvement
    A M Florena
    Istituto di Anatomia ed Istologia Patologica, Universita degli Studi di Palermo, Italy
    Leuk Lymphoma 47:49-57. 2006
    ..E-selectin, L-selectin and beta-1 integrin proved constantly negative. These data suggest that different expression of AM can influence the modality of BM infiltration in SMZL...
  75. ncbi request reprint Impact of liver steatosis on the antiviral response in the hepatitis C virus-associated chronic hepatitis
    M Soresi
    Cattedra di Medicina Interna e Cattedra di Medicina d Urgenza, Dipartimento di Medicina, Clinica e delle Patologie Emergenti, Universita di Palermo, Cattedra di Anatomia Patologia, Palermo, Italy
    Liver Int 26:1119-25. 2006
    ....
  76. pmc Study of axillary lymph node asymmetry in a female population
    F Cappello
    Department of Experimental Medicine, University of Palermo, Italy
    J Anat 199:617-20. 2001
    ..The distribution of hyperplastic node patterns differed significantly...
  77. ncbi request reprint Lymph node metastasis in lower lip squamous cell carcinoma in relation to tumour size, histologic variables and p27Kip1 protein expression
    Vito Rodolico
    Institute of Pathological Anatomy and Histology, University of Palermo, Via del Vespro 129, 90127 Palermo, Italy
    Oral Oncol 40:92-8. 2004
    ..7%) are at high risk for the development of lymph node metastases...