Affiliation: York University
- Consumption of a high-fat diet rapidly exacerbates the development of fatty liver disease that occurs with chronically elevated glucocorticoidsAnna M D'souza
Muscle Health Research Center and Physical Activity and Chronic Disease Unit, School of Kinesiology and Health Science, Faculty of Health, York University, Toronto, Ontario, Canada
Am J Physiol Gastrointest Liver Physiol 302:G850-63. 2012..Thus a HFD dramatically exacerbates the development of NAFLD and characteristics of the metabolic syndrome in conditions of chronically elevated Cort...
- Physical activity, sport, and pediatric diabetesM C Riddell
Kinesiology and Health Science, York University, Bethune College, Toronto, Canada
Pediatr Diabetes 7:60-70. 2006....
- The endocrine response and substrate utilization during exercise in children and adolescentsMichael C Riddell
School of Kinesiology and Health Science, Faculty of Health York University, Toronto, ON, Canada M3J 1P3
J Appl Physiol 105:725-33. 2008..Studies are also needed to determine whether physical activity, at an intensity targeted to maximize fat oxidation, help to lower body adiposity in overweight youth...
- Fat oxidation rate and the exercise intensity that elicits maximal fat oxidation decreases with pubertal status in young male subjectsM C Riddell
School of Kinesiology and Health Science, Faculty of Health, York University, 4700 Keele St, Toronto, ON, Canada M3J 1P3
J Appl Physiol 105:742-8. 2008..06). We conclude that, compared with men, prepubertal boys have higher relative FOR throughout a wide range of exercise intensities and that FOR drops as boys develop through puberty...
- Exercise and glucose metabolism in persons with diabetes mellitus: perspectives on the role for continuous glucose monitoringMichael Riddell
School of Kinesiology and Health Science, Muscle Research Centre, Faculty of Health, York University, Toronto, Ontario, Canada
J Diabetes Sci Technol 3:914-23. 2009....
- Preventing exercise-induced hypoglycemia in type 1 diabetes using real-time continuous glucose monitoring and a new carbohydrate intake algorithm: an observational field studyMichael C Riddell
School of Kinesiology and Health Science, Muscle Health Research Centre, Physical Activity and Diabetes Unit, York University, Toronto, Ontario, Canada
Diabetes Technol Ther 13:819-25. 2011..The purpose of this observational field study was to test the effectiveness of RT-GCM and a new carbohydrate intake algorithm designed for maintaining euglycemia during sports...
- Energy substrate utilization during prolonged exercise with and without carbohydrate intake in preadolescent and adolescent girlsBrian W Timmons
Children s Exercise and Nutrition Centre, McMaster University, Hamilton, Ontario, Canada
J Appl Physiol 103:995-1000. 2007..Our results also point to potential sex-related differences in energy substrate utilization even during childhood...
- Influence of age and pubertal status on substrate utilization during exercise with and without carbohydrate intake in healthy boysBrian W Timmons
Children s Exercise and Nutrition Centre, Chedoke Hospital, McMaster University, Hamilton, Ontario, Canada
Appl Physiol Nutr Metab 32:416-25. 2007..51, p=0.005, n=29). It was concluded that reliance on CHOexo during exercise is particularly sensitive to pubertal status, with the highest oxidation rates observed in pre- and early-pubertal boys, independent of chronological age...
- Efficacy of continuous real-time blood glucose monitoring during and after prolonged high-intensity cycling exercise: spinning with a continuous glucose monitoring systemKatherine E Iscoe
School of Kinesiology and Health Science, York University, Toronto, Ontario, Canada
Diabetes Technol Ther 8:627-35. 2006..Further study into clinical strategies for preventing hypoglycemia associated with this common form of mixed aerobic and anaerobic exercise is urgently needed through insulin modification and carbohydrate supplementation...
- Circulating adiponectin and adiponectin receptor expression in skeletal muscle: effects of exerciseVivian Vu
Department of Biology, York University, Toronto, Canada
Diabetes Metab Res Rev 23:600-11. 2007..In this review, we have summarized the key findings to date which suggest that changes in expression of AdipoR isoforms in skeletal muscle, rather than circulating total adiponectin levels, may be of physiological importance...
- Adipogenic and lipolytic effects of chronic glucocorticoid exposureJonathan E Campbell
York University, Toronto, Ontario, Canada
Am J Physiol Cell Physiol 300:C198-209. 2011..05). Taken together, our findings demonstrate that chronic glucocorticoid exposure stimulates both lipolysis and adipogenesis in visceral adipose tissue but favors adipogenesis primarily through preadipocyte differentiation...
- Effect of voluntary wheel running on circadian corticosterone release and on HPA axis responsiveness to restraint stress in Sprague-Dawley ratsSergiu Fediuc
School of Kinesiology and Health Science, Faculty of Pure and Applied Science, York University, 4700 Keele St, Toronto, ON, Canada M3J 1P3
J Appl Physiol 100:1867-75. 2006....
- Regular exercise prevents the development of hyperglucocorticoidemia via adaptations in the brain and adrenal glands in male Zucker diabetic fatty ratsJonathan E Campbell
School of Kinesiology and Health Science, Faculty of Health, Muscle Health Research Centre, York University, Canada
Am J Physiol Regul Integr Comp Physiol 299:R168-76. 2010....
- Changes in basal hypothalamo-pituitary-adrenal activity during exercise training are centrally mediatedEdward Park
School of Kinesiology and Health Science, York University, 4700 Keele St, Toronto, Ontario, Canada M3J 1P3
Am J Physiol Regul Integr Comp Physiol 289:R1360-71. 2005..In contrast, the increase in basal pituitary-adrenal activity with repeated sham exercise appears to be associated with decreases in hippocampal MR and PVN GR mRNA expression...
- The role of physical activity in type 2 diabetes prevention: physiological and practical perspectivesJamie F Burr
Physical Activity and Chronic Disease Unit, School of Kinesiology and Health Science, Faculty of Health, York University, Toronto, Ontario, M3J 1P3, Canada
Phys Sportsmed 38:72-82. 2010..We also provide an evidence-informed prescription for the type, intensity, and duration of both resistance and aerobic PA in persons with prediabetes...
- Effect of voluntary exercise on peripheral tissue glucocorticoid receptor content and the expression and activity of 11beta-HSD1 in the Syrian hamsterAgnes E Coutinho
Department of Kinesiology and Health Science, York University, Toronto, Ontario, Canada
J Appl Physiol 100:1483-8. 2006..These adaptations may have important implications in explaining the protective effects of aerobic exercise on insulin resistance and other symptoms of the metabolic syndrome...
- Metabolic effects of voluntary wheel running in young and old Syrian golden hamstersAgnes E Coutinho
School of Kinesiology and Health Science, Faculty of Pure and Applied Science, York University, 4700 Keele Street, Toronto, ON, Canada, M3J 1P3
Physiol Behav 87:360-7. 2006....
- Substrate utilization during exercise performed with and without glucose ingestion in female and male endurance trained athletesMichael C Riddell
Department of Kinesiology and Health Science at York University, Toronto, Canada
Int J Sport Nutr Exerc Metab 13:407-21. 2003..Based on these observations, ingested carbohydrate may be a particularly beneficial source of fuel during endurance exercise for females...
- Streptozotocin induces G2 arrest in skeletal muscle myoblasts and impairs muscle growth in vivoAdam P W Johnston
School of Kinesiology and Health Science, York University, Toronto, Ontario, Canada M3J 1P3
Am J Physiol Cell Physiol 292:C1033-40. 2007..Taken together, our findings show that the effects of STZ are not beta-cell specific and reveal that STZ should not be used for studies examining diabetic myopathy...
- Adiponectin is expressed by skeletal muscle fibers and influences muscle phenotype and functionMatthew P Krause
School of Kinesiology and Health Science, York University, Toronto, Ontario, Canada
Am J Physiol Cell Physiol 295:C203-12. 2008..Furthermore, we demonstrate that Ad is expressed in skeletal muscle and that its intramyocellular localization is associated with elevated IMCL, particularly in type IIA/D fibers...
- Oxidation rate of exogenous carbohydrate during exercise is higher in boys than in menBrian W Timmons
Children's Exercise and Nutrition Centre, McMaster University, Hamilton L8N 3Z5, Canada M3J 1P3
J Appl Physiol 94:278-84. 2003..The greater reliance on CHO(exo) in boys may be important in preserving endogenous fuels and may be related to pubertal status...
- Hyperglycemia does not increase basal hypothalamo-pituitary-adrenal activity in diabetes but it does impair the HPA response to insulin-induced hypoglycemiaOwen Chan
Department of Physiology, 1 King's College Circle, Medical Sciences Bldg. Rm. 3358, University of Toronto, Toronto, Ontario M5S 1A8, Canada
Am J Physiol Regul Integr Comp Physiol 289:R235-46. 2005....
- Effects of insulin treatment without and with recurrent hypoglycemia on hypoglycemic counterregulation and adrenal catecholamine-synthesizing enzymes in diabetic ratsKaren E Inouye
Departments of Physiology, University of Toronto, Ontario, Canada
Endocrinology 147:1860-70. 2006..Protection against epinephrine defects, both without and with antecedent hypoglycemia, is associated with enhancement of adrenal catecholamine-synthesizing enzyme levels...
- Attenuation of type 2 diabetes mellitus in the male Zucker diabetic fatty rat: the effects of stress and non-volitional exerciseMichael A Kiraly
Department of Physiology, Medical Sciences Building, University of Toronto, Toronto, Ontario, Canada
Metabolism 56:732-44. 2007..In summary, both exercise and sham treatment delay the progression of type 2 diabetes mellitus in the male ZDF rat by distinct mechanisms related to pancreatic function and improvements in peripheral glucose disposal...
- Recurrent intermittent restraint delays fed and fasting hyperglycemia and improves glucose return to baseline levels during glucose tolerance tests in the Zucker diabetic fatty rat--role of food intake and corticosteroneHolly E Bates
Department of Physiology, University of Toronto, Toronto, Canada
Metabolism 56:1065-75. 2007..Paradoxically, these novel investigations suggest some types of occasional stress may limit development of diabetes...
- Swim training prevents hyperglycemia in ZDF rats: mechanisms involved in the partial maintenance of beta-cell functionMichael A Kiraly
Department of Physiology, University of Toronto, 1 King s College Circle, Toronto, Ontario, Canada
Am J Physiol Endocrinol Metab 294:E271-83. 2008..In conclusion, improved beta-cell compensation through increased beta-cell function and mass occurs in exercised but not sedentary ZDF rats and may be in part responsible for improved glucoregulation...
- Partial leptin restoration increases hypothalamic-pituitary-adrenal activity while diminishing weight loss and hyperphagia in streptozotocin diabetic ratsEitan M Akirav
Department of Physiology, University of Toronto, Ontraio, Canada
Metabolism 53:1558-64. 2004....
- Adaptation to intermittent stress promotes maintenance of beta-cell compensation: comparison with food restrictionHolly E Bates
Department of Physiology, University of Toronto, Toronto, Ontario, Canada
Am J Physiol Endocrinol Metab 295:E947-58. 2008..Thus, preservation of beta-cell mass with adaptation to intermittent stress is related to beta-cell hyperplasia, maintenance of insulin responses to glucose, and reductions in alpha-cell mass that do not occur with food restriction...
- Insulin alone increases hypothalamo-pituitary-adrenal activity, and diabetes lowers peak stress responsesOwen Chan
Department of Physiology, University of Toronto, Medical Sciences Building, Room 3240, 1 King s College Circle, Toronto, Ontario, Canada M5S 1A8
Endocrinology 146:1382-90. 2005..In diabetes, this ability is impaired; hence, maximal HPA activation is greatly diminished. This is a novel observation that may have important implications in the treatment of impaired counterregulatory mechanisms in human diabetes...
- National athletic trainers' association position statement: management of the athlete with type 1 diabetes mellitusCarolyn C Jimenez
West Chester University, West Chester, PA, USA
J Athl Train 42:536-45. 2007..To present recommendations for the certified athletic trainer in the management of type 1 diabetes in the athlete...
- Exercise in children and adolescents with diabetesKenneth Robertson
Dasman Centre for Research and Treatment of Diabetes, Kuwait
Pediatr Diabetes 9:65-77. 2008