Michael Riddell

Summary

Affiliation: York University
Country: Canada

Publications

  1. pmc Effects of selective and non-selective glucocorticoid receptor II antagonists on rapid-onset diabetes in young rats
    Jacqueline L Beaudry
    School of Kinesiology and Health Science, Faculty of Health, Muscle Health Research Center and Physical Activity and Chronic Disease Unit, York University, Toronto, Ontario, Canada
    PLoS ONE 9:e91248. 2014
  2. pmc A rodent model of rapid-onset diabetes induced by glucocorticoids and high-fat feeding
    Yaniv Shpilberg
    York University, 4700 Keele Street, Toronto, ON M3J 1P3, Canada
    Dis Model Mech 5:671-80. 2012
  3. pmc Impaired growth and force production in skeletal muscles of young partially pancreatectomized rats: a model of adolescent type 1 diabetic myopathy?
    Carly S Gordon
    School of Kinesiology and Health Science, York University, Toronto, Ontario, Canada
    PLoS ONE 5:e14032. 2010
  4. doi request reprint Exogenous glucocorticoids and a high-fat diet cause severe hyperglycemia and hyperinsulinemia and limit islet glucose responsiveness in young male Sprague-Dawley rats
    Jacqueline L Beaudry
    School of Kinesiology and Health Science, Faculty of Health, Muscle Health Research Center and Physical Activity and Chronic Disease Unit, York University, 4700 Keele Street, Toronto, ON, Canada M3J 1P3
    Endocrinology 154:3197-208. 2013
  5. doi request reprint Evidence-based risk assessment and recommendations for physical activity clearance: diabetes mellitus and related comorbidities
    Michael C Riddell
    School of Kinesiology and Health Science, Muscle Health Research Centre, Physical Activity and Chronic Disease Unit, York University, 4700 Keele Street, Toronto, ON, Canada
    Appl Physiol Nutr Metab 36:S154-89. 2011
  6. ncbi request reprint Consumption of a high-fat diet rapidly exacerbates the development of fatty liver disease that occurs with chronically elevated glucocorticoids
    Anna M D'souza
    Muscle Health Research Center and Physical Activity and Chronic Disease Unit, School of Kinesiology and Health Science, Faculty of Health, York University, Toronto, Ontario, Canada
    Am J Physiol Gastrointest Liver Physiol 302:G850-63. 2012
  7. doi request reprint Preventing exercise-induced hypoglycemia in type 1 diabetes using real-time continuous glucose monitoring and a new carbohydrate intake algorithm: an observational field study
    Michael C Riddell
    School of Kinesiology and Health Science, Muscle Health Research Centre, Physical Activity and Diabetes Unit, York University, Toronto, Ontario, Canada
    Diabetes Technol Ther 13:819-25. 2011
  8. ncbi request reprint The endocrine response and substrate utilization during exercise in children and adolescents
    Michael C Riddell
    School of Kinesiology and Health Science, Faculty of Health York University, Toronto, ON, Canada M3J 1P3
    J Appl Physiol (1985) 105:725-33. 2008
  9. ncbi request reprint Fat oxidation rate and the exercise intensity that elicits maximal fat oxidation decreases with pubertal status in young male subjects
    M C Riddell
    School of Kinesiology and Health Science, Faculty of Health, York University, 4700 Keele St, Toronto, ON, Canada M3J 1P3
    J Appl Physiol (1985) 105:742-8. 2008
  10. pmc Exercise and glucose metabolism in persons with diabetes mellitus: perspectives on the role for continuous glucose monitoring
    Michael Riddell
    School of Kinesiology and Health Science, Muscle Research Centre, Faculty of Health, York University, Toronto, Ontario, Canada
    J Diabetes Sci Technol 3:914-23. 2009

Collaborators

  • Thomas J Hawke
  • Jacqueline L Beaudry
  • Arend Bonen
  • Brian W Timmons
  • M Tarnopolsky
  • Olasunkanmi A J Adegoke
  • Ragnar Hanas
  • LAWRENCE C CHAN
  • Stephen J Trumble
  • Aimin Xu
  • Gary Scheiner
  • Jonathan E Campbell
  • Mladen Vranic
  • Stephen G Matthews
  • Michael A Kiraly
  • Owen Chan
  • Holly E Bates
  • Edward Park
  • Jessica T Y Yue
  • Anna M D'souza
  • Sergiu Fediuc
  • Agnes E Coutinho
  • Eitan M Akirav
  • Matthew P Krause
  • Vivian Vu
  • Karen Inouye
  • Yaniv Shpilberg
  • Carly S Gordon
  • Jamie F Burr
  • Kenneth Robertson
  • Gary Sweeney
  • Adam P W Johnston
  • Carolyn C Jimenez
  • Katherine E Iscoe
  • Karen E Inouye
  • Anna D'Souza
  • Laelie A Snook
  • Adria Giacca
  • Andrei A Szigiato
  • Ashley Peckett
  • Ashley J Peckett
  • Enzo Cafarelli
  • Veronica K Jamnik
  • Chip P Rowan
  • Antonio S Serino
  • Daniel J Atkinson
  • John H Brumell
  • Natalia A Kaniuk
  • Ying Liu
  • Peter Adolfsson
  • Adam Sirek
  • James T Crawley
  • Matthew H Corcoran
  • Danitza Goche Montes
  • Danitza Goche-Montes
  • Melanie E Elliott
  • Kimberly S Peer
  • Rick D Philbin
  • W Guyton Hornsby
  • Jeremy G Found
  • Veronica Jamnik
  • Elena Burdett
  • Bruce A Perkins
  • Tony Kim
  • Mike Kiraly
  • Qifu Li
  • Eitan Akirav

Detail Information

Publications37

  1. pmc Effects of selective and non-selective glucocorticoid receptor II antagonists on rapid-onset diabetes in young rats
    Jacqueline L Beaudry
    School of Kinesiology and Health Science, Faculty of Health, Muscle Health Research Center and Physical Activity and Chronic Disease Unit, York University, Toronto, Ontario, Canada
    PLoS ONE 9:e91248. 2014
    ..In summary, C113176 is an effective agent that minimized some GC-induced detrimental metabolic effects and may provide an alternative to the effective, but non-selective, GRII antagonist RU486. ..
  2. pmc A rodent model of rapid-onset diabetes induced by glucocorticoids and high-fat feeding
    Yaniv Shpilberg
    York University, 4700 Keele Street, Toronto, ON M3J 1P3, Canada
    Dis Model Mech 5:671-80. 2012
    ..This finding might be valuable in examining the physiological and molecular mechanisms of GC-induced metabolic disease...
  3. pmc Impaired growth and force production in skeletal muscles of young partially pancreatectomized rats: a model of adolescent type 1 diabetic myopathy?
    Carly S Gordon
    School of Kinesiology and Health Science, York University, Toronto, Ontario, Canada
    PLoS ONE 5:e14032. 2010
    ..Taken together, these data indicate that exposure of growing skeletal muscle to uncontrolled T1DM significantly impairs muscle growth and function largely as a result of impaired protein synthesis in type II fibers...
  4. doi request reprint Exogenous glucocorticoids and a high-fat diet cause severe hyperglycemia and hyperinsulinemia and limit islet glucose responsiveness in young male Sprague-Dawley rats
    Jacqueline L Beaudry
    School of Kinesiology and Health Science, Faculty of Health, Muscle Health Research Center and Physical Activity and Chronic Disease Unit, York University, 4700 Keele Street, Toronto, ON, Canada M3J 1P3
    Endocrinology 154:3197-208. 2013
    ..Thus, CORT and HFD, synergistically not independently, act to promote severe insulin resistance, which overwhelms islet adaptive capacity, thereby resulting in overt hyperglycemia...
  5. doi request reprint Evidence-based risk assessment and recommendations for physical activity clearance: diabetes mellitus and related comorbidities
    Michael C Riddell
    School of Kinesiology and Health Science, Muscle Health Research Centre, Physical Activity and Chronic Disease Unit, York University, 4700 Keele Street, Toronto, ON, Canada
    Appl Physiol Nutr Metab 36:S154-89. 2011
    ....
  6. ncbi request reprint Consumption of a high-fat diet rapidly exacerbates the development of fatty liver disease that occurs with chronically elevated glucocorticoids
    Anna M D'souza
    Muscle Health Research Center and Physical Activity and Chronic Disease Unit, School of Kinesiology and Health Science, Faculty of Health, York University, Toronto, Ontario, Canada
    Am J Physiol Gastrointest Liver Physiol 302:G850-63. 2012
    ..Thus a HFD dramatically exacerbates the development of NAFLD and characteristics of the metabolic syndrome in conditions of chronically elevated Cort...
  7. doi request reprint Preventing exercise-induced hypoglycemia in type 1 diabetes using real-time continuous glucose monitoring and a new carbohydrate intake algorithm: an observational field study
    Michael C Riddell
    School of Kinesiology and Health Science, Muscle Health Research Centre, Physical Activity and Diabetes Unit, York University, Toronto, Ontario, Canada
    Diabetes Technol Ther 13:819-25. 2011
    ..The purpose of this observational field study was to test the effectiveness of RT-GCM and a new carbohydrate intake algorithm designed for maintaining euglycemia during sports...
  8. ncbi request reprint The endocrine response and substrate utilization during exercise in children and adolescents
    Michael C Riddell
    School of Kinesiology and Health Science, Faculty of Health York University, Toronto, ON, Canada M3J 1P3
    J Appl Physiol (1985) 105:725-33. 2008
    ..Studies are also needed to determine whether physical activity, at an intensity targeted to maximize fat oxidation, help to lower body adiposity in overweight youth...
  9. ncbi request reprint Fat oxidation rate and the exercise intensity that elicits maximal fat oxidation decreases with pubertal status in young male subjects
    M C Riddell
    School of Kinesiology and Health Science, Faculty of Health, York University, 4700 Keele St, Toronto, ON, Canada M3J 1P3
    J Appl Physiol (1985) 105:742-8. 2008
    ..06). We conclude that, compared with men, prepubertal boys have higher relative FOR throughout a wide range of exercise intensities and that FOR drops as boys develop through puberty...
  10. pmc Exercise and glucose metabolism in persons with diabetes mellitus: perspectives on the role for continuous glucose monitoring
    Michael Riddell
    School of Kinesiology and Health Science, Muscle Research Centre, Faculty of Health, York University, Toronto, Ontario, Canada
    J Diabetes Sci Technol 3:914-23. 2009
    ....
  11. ncbi request reprint Physical activity, sport, and pediatric diabetes
    M C Riddell
    Kinesiology and Health Science, York University, Bethune College, Toronto, Canada
    Pediatr Diabetes 7:60-70. 2006
    ....
  12. ncbi request reprint Influence of age and pubertal status on substrate utilization during exercise with and without carbohydrate intake in healthy boys
    Brian W Timmons
    Children s Exercise and Nutrition Centre, Chedoke Hospital, McMaster University, Hamilton, Ontario, Canada
    Appl Physiol Nutr Metab 32:416-25. 2007
    ..51, p=0.005, n=29). It was concluded that reliance on CHOexo during exercise is particularly sensitive to pubertal status, with the highest oxidation rates observed in pre- and early-pubertal boys, independent of chronological age...
  13. ncbi request reprint Efficacy of continuous real-time blood glucose monitoring during and after prolonged high-intensity cycling exercise: spinning with a continuous glucose monitoring system
    Katherine E Iscoe
    School of Kinesiology and Health Science, York University, Toronto, Ontario, Canada
    Diabetes Technol Ther 8:627-35. 2006
    ..Continuous glucose monitoring systems have recently emerged as a potentially important tool in diabetes management, allowing individuals to track glucose levels continuously and learn how various behaviors influence glucose control...
  14. ncbi request reprint Energy substrate utilization during prolonged exercise with and without carbohydrate intake in preadolescent and adolescent girls
    Brian W Timmons
    Children s Exercise and Nutrition Centre, McMaster University, Hamilton, Ontario, Canada
    J Appl Physiol 103:995-1000. 2007
    ..Our results also point to potential sex-related differences in energy substrate utilization even during childhood...
  15. ncbi request reprint Circulating adiponectin and adiponectin receptor expression in skeletal muscle: effects of exercise
    Vivian Vu
    Department of Biology, York University, Toronto, Canada
    Diabetes Metab Res Rev 23:600-11. 2007
    ..In this review, we have summarized the key findings to date which suggest that changes in expression of AdipoR isoforms in skeletal muscle, rather than circulating total adiponectin levels, may be of physiological importance...
  16. doi request reprint Adipogenic and lipolytic effects of chronic glucocorticoid exposure
    Jonathan E Campbell
    York University, Toronto, Ontario, Canada
    Am J Physiol Cell Physiol 300:C198-209. 2011
    ..05). Taken together, our findings demonstrate that chronic glucocorticoid exposure stimulates both lipolysis and adipogenesis in visceral adipose tissue but favors adipogenesis primarily through preadipocyte differentiation...
  17. ncbi request reprint Metabolic effects of voluntary wheel running in young and old Syrian golden hamsters
    Agnes E Coutinho
    School of Kinesiology and Health Science, Faculty of Pure and Applied Science, York University, 4700 Keele Street, Toronto, ON, Canada, M3J 1P3
    Physiol Behav 87:360-7. 2006
    ....
  18. ncbi request reprint Effect of voluntary wheel running on circadian corticosterone release and on HPA axis responsiveness to restraint stress in Sprague-Dawley rats
    Sergiu Fediuc
    School of Kinesiology and Health Science, Faculty of Pure and Applied Science, York University, 4700 Keele St, Toronto, ON, Canada M3J 1P3
    J Appl Physiol 100:1867-75. 2006
    ....
  19. ncbi request reprint Effect of voluntary exercise on peripheral tissue glucocorticoid receptor content and the expression and activity of 11beta-HSD1 in the Syrian hamster
    Agnes E Coutinho
    Department of Kinesiology and Health Science, York University, Toronto, Ontario, Canada
    J Appl Physiol 100:1483-8. 2006
    ..These adaptations may have important implications in explaining the protective effects of aerobic exercise on insulin resistance and other symptoms of the metabolic syndrome...
  20. doi request reprint The role of physical activity in type 2 diabetes prevention: physiological and practical perspectives
    Jamie F Burr
    Physical Activity and Chronic Disease Unit, School of Kinesiology and Health Science, Faculty of Health, York University, Toronto, Ontario, M3J 1P3, Canada
    Phys Sportsmed 38:72-82. 2010
    ..We also provide an evidence-informed prescription for the type, intensity, and duration of both resistance and aerobic PA in persons with prediabetes...
  21. ncbi request reprint Changes in basal hypothalamo-pituitary-adrenal activity during exercise training are centrally mediated
    Edward Park
    School of Kinesiology and Health Science, York University, 4700 Keele St, Toronto, Ontario, Canada M3J 1P3
    Am J Physiol Regul Integr Comp Physiol 289:R1360-71. 2005
    ..In contrast, the increase in basal pituitary-adrenal activity with repeated sham exercise appears to be associated with decreases in hippocampal MR and PVN GR mRNA expression...
  22. pmc Adiponectin is expressed by skeletal muscle fibers and influences muscle phenotype and function
    Matthew P Krause
    School of Kinesiology and Health Science, York University, Toronto, Ontario, Canada
    Am J Physiol Cell Physiol 295:C203-12. 2008
    ..Furthermore, we demonstrate that Ad is expressed in skeletal muscle and that its intramyocellular localization is associated with elevated IMCL, particularly in type IIA/D fibers...
  23. ncbi request reprint Substrate utilization during exercise performed with and without glucose ingestion in female and male endurance trained athletes
    Michael C Riddell
    Department of Kinesiology and Health Science at York University, Toronto, Canada
    Int J Sport Nutr Exerc Metab 13:407-21. 2003
    ..Based on these observations, ingested carbohydrate may be a particularly beneficial source of fuel during endurance exercise for females...
  24. doi request reprint Regular exercise prevents the development of hyperglucocorticoidemia via adaptations in the brain and adrenal glands in male Zucker diabetic fatty rats
    Jonathan E Campbell
    School of Kinesiology and Health Science, Faculty of Health, Muscle Health Research Centre, York University, Canada
    Am J Physiol Regul Integr Comp Physiol 299:R168-76. 2010
    ....
  25. ncbi request reprint Streptozotocin induces G2 arrest in skeletal muscle myoblasts and impairs muscle growth in vivo
    Adam P W Johnston
    School of Kinesiology and Health Science, York University, Toronto, Ontario, Canada M3J 1P3
    Am J Physiol Cell Physiol 292:C1033-40. 2007
    ..Taken together, our findings show that the effects of STZ are not beta-cell specific and reveal that STZ should not be used for studies examining diabetic myopathy...
  26. ncbi request reprint Oxidation rate of exogenous carbohydrate during exercise is higher in boys than in men
    Brian W Timmons
    Children s Exercise and Nutrition Centre, McMaster University, Hamilton L8N 3Z5, Canada M3J 1P3
    J Appl Physiol 94:278-84. 2003
    ..The greater reliance on CHO(exo) in boys may be important in preserving endogenous fuels and may be related to pubertal status...
  27. doi request reprint Adaptation to intermittent stress promotes maintenance of beta-cell compensation: comparison with food restriction
    Holly E Bates
    Department of Physiology, University of Toronto, Toronto, Ontario, Canada
    Am J Physiol Endocrinol Metab 295:E947-58. 2008
    ..Thus, preservation of beta-cell mass with adaptation to intermittent stress is related to beta-cell hyperplasia, maintenance of insulin responses to glucose, and reductions in alpha-cell mass that do not occur with food restriction...
  28. ncbi request reprint Partial leptin restoration increases hypothalamic-pituitary-adrenal activity while diminishing weight loss and hyperphagia in streptozotocin diabetic rats
    Eitan M Akirav
    Department of Physiology, University of Toronto, Ontraio, Canada
    Metabolism 53:1558-64. 2004
    ....
  29. ncbi request reprint Insulin alone increases hypothalamo-pituitary-adrenal activity, and diabetes lowers peak stress responses
    Owen Chan
    Department of Physiology, University of Toronto, Medical Sciences Building, Room 3240, 1 King s College Circle, Toronto, Ontario, Canada M5S 1A8
    Endocrinology 146:1382-90. 2005
    ..In diabetes, this ability is impaired; hence, maximal HPA activation is greatly diminished. This is a novel observation that may have important implications in the treatment of impaired counterregulatory mechanisms in human diabetes...
  30. ncbi request reprint Hyperglycemia does not increase basal hypothalamo-pituitary-adrenal activity in diabetes but it does impair the HPA response to insulin-induced hypoglycemia
    Owen Chan
    Department of Physiology, 1 King s College Circle, Medical Sciences Bldg Rm 3358, University of Toronto, Toronto, Ontario M5S 1A8, Canada
    Am J Physiol Regul Integr Comp Physiol 289:R235-46. 2005
    ....
  31. ncbi request reprint Effects of insulin treatment without and with recurrent hypoglycemia on hypoglycemic counterregulation and adrenal catecholamine-synthesizing enzymes in diabetic rats
    Karen E Inouye
    Departments of Physiology, University of Toronto, Ontario, Canada
    Endocrinology 147:1860-70. 2006
    ..Protection against epinephrine defects, both without and with antecedent hypoglycemia, is associated with enhancement of adrenal catecholamine-synthesizing enzyme levels...
  32. ncbi request reprint Attenuation of type 2 diabetes mellitus in the male Zucker diabetic fatty rat: the effects of stress and non-volitional exercise
    Michael A Kiraly
    Department of Physiology, Medical Sciences Building, University of Toronto, Toronto, Ontario, Canada
    Metabolism 56:732-44. 2007
    ..In summary, both exercise and sham treatment delay the progression of type 2 diabetes mellitus in the male ZDF rat by distinct mechanisms related to pancreatic function and improvements in peripheral glucose disposal...
  33. ncbi request reprint Recurrent intermittent restraint delays fed and fasting hyperglycemia and improves glucose return to baseline levels during glucose tolerance tests in the Zucker diabetic fatty rat--role of food intake and corticosterone
    Holly E Bates
    Department of Physiology, University of Toronto, Toronto, Canada
    Metabolism 56:1065-75. 2007
    ..Paradoxically, these novel investigations suggest some types of occasional stress may limit development of diabetes...
  34. pmc National athletic trainers' association position statement: management of the athlete with type 1 diabetes mellitus
    Carolyn C Jimenez
    West Chester University, West Chester, PA, USA
    J Athl Train 42:536-45. 2007
    ..To present recommendations for the certified athletic trainer in the management of type 1 diabetes in the athlete...
  35. doi request reprint Exercise in children and adolescents with diabetes
    Kenneth Robertson
    Dasman Centre for Research and Treatment of Diabetes, Kuwait
    Pediatr Diabetes 9:65-77. 2008
  36. ncbi request reprint Swim training prevents hyperglycemia in ZDF rats: mechanisms involved in the partial maintenance of beta-cell function
    Michael A Kiraly
    Department of Physiology, University of Toronto, 1 King s College Circle, Toronto, Ontario, Canada
    Am J Physiol Endocrinol Metab 294:E271-83. 2008
    ..In conclusion, improved beta-cell compensation through increased beta-cell function and mass occurs in exercised but not sedentary ZDF rats and may be in part responsible for improved glucoregulation...