T L Haas

Summary

Affiliation: York University
Country: Canada

Publications

  1. ncbi request reprint Nitric oxide and p38 MAP kinase mediate shear stress-dependent inhibition of MMP-2 production in microvascular endothelial cells
    Malgorzata Milkiewicz
    School of Kinesiology and Health Sciences, York University, Toronto, Ontario, Canada
    J Cell Physiol 208:229-37. 2006
  2. ncbi request reprint Matrix metalloproteinase activity is required for activity-induced angiogenesis in rat skeletal muscle
    T L Haas
    Department of Pathology, Yale University, New Haven, Connecticut 06515, USA
    Am J Physiol Heart Circ Physiol 279:H1540-7. 2000
  3. ncbi request reprint Involvement of MMPs in the outward remodeling of collateral mesenteric arteries
    Tara L Haas
    School of Kinesiology and Health Sciences, Rm 341 Farquharson, York Univ, 4700 Keele St, Toronto, ON Canada M3J 1P3
    Am J Physiol Heart Circ Physiol 293:H2429-37. 2007
  4. ncbi request reprint Endothelial cell regulation of matrix metalloproteinases
    Tara L Haas
    School of Kinesiology and Health Sciences, York University, Toronto, ON, Canada
    Can J Physiol Pharmacol 83:1-7. 2005
  5. doi request reprint Cdc42 and RhoA have opposing roles in regulating membrane type 1-matrix metalloproteinase localization and matrix metalloproteinase-2 activation
    Eric Ispanovic
    School of Kinesiology and Health Sciences, York University, Toronto, Ontario, Canada M3J 1P3
    Am J Physiol Cell Physiol 295:C600-10. 2008
  6. ncbi request reprint Transcriptional up-regulation of endothelial cell matrix metalloproteinase-2 in response to extracellular cues involves GATA-2
    Xiaoyan Han
    School of Kinesiology and Health Sciences, York University, Toronto, Ontario M3J 1P3, Canada
    J Biol Chem 278:47785-91. 2003
  7. doi request reprint Shear stress-induced Ets-1 modulates protease inhibitor expression in microvascular endothelial cells
    Malgorzata Milkiewicz
    School of Kinesiology and Health Science, York University, Toronto, Ontario, Canada
    J Cell Physiol 217:502-10. 2008
  8. ncbi request reprint JNK and PI3K differentially regulate MMP-2 and MT1-MMP mRNA and protein in response to actin cytoskeleton reorganization in endothelial cells
    Eric Ispanovic
    School of Kinesiology and Health Sciences, York Univ, 4700 Keele St, Toronto, Ontario, Canada M3J 1P3
    Am J Physiol Cell Physiol 291:C579-88. 2006
  9. ncbi request reprint Molecular control of capillary growth in skeletal muscle
    Tara L Haas
    Department of Kinesiology and Health Sciences, York University, Toronto, Ontario, Canada
    Can J Appl Physiol 27:491-515. 2002
  10. ncbi request reprint MAPK signaling regulates endothelial cell assembly into networks and expression of MT1-MMP and MMP-2
    Pamela J Boyd
    School of Kinesiology and Health Sciences, Farquharson Bldg, Rm 341, York University, 4700 Keele St, Toronto, Ontario, Canada M3J 1P3
    Am J Physiol Cell Physiol 288:C659-68. 2005

Collaborators

Detail Information

Publications19

  1. ncbi request reprint Nitric oxide and p38 MAP kinase mediate shear stress-dependent inhibition of MMP-2 production in microvascular endothelial cells
    Malgorzata Milkiewicz
    School of Kinesiology and Health Sciences, York University, Toronto, Ontario, Canada
    J Cell Physiol 208:229-37. 2006
    ..Thus, our data provide strong evidence that elevated shear stress inhibits MMP-2 production in microvascular endothelial cells, an effect that is mediated by signal pathways involving both production of NO and activation of p38 MAPK...
  2. ncbi request reprint Matrix metalloproteinase activity is required for activity-induced angiogenesis in rat skeletal muscle
    T L Haas
    Department of Pathology, Yale University, New Haven, Connecticut 06515, USA
    Am J Physiol Heart Circ Physiol 279:H1540-7. 2000
    ....
  3. ncbi request reprint Involvement of MMPs in the outward remodeling of collateral mesenteric arteries
    Tara L Haas
    School of Kinesiology and Health Sciences, Rm 341 Farquharson, York Univ, 4700 Keele St, Toronto, ON Canada M3J 1P3
    Am J Physiol Heart Circ Physiol 293:H2429-37. 2007
    ....
  4. ncbi request reprint Endothelial cell regulation of matrix metalloproteinases
    Tara L Haas
    School of Kinesiology and Health Sciences, York University, Toronto, ON, Canada
    Can J Physiol Pharmacol 83:1-7. 2005
    ....
  5. doi request reprint Cdc42 and RhoA have opposing roles in regulating membrane type 1-matrix metalloproteinase localization and matrix metalloproteinase-2 activation
    Eric Ispanovic
    School of Kinesiology and Health Sciences, York University, Toronto, Ontario, Canada M3J 1P3
    Am J Physiol Cell Physiol 295:C600-10. 2008
    ..Furthermore, VEGF-dependent activation of MMP-2 was reduced by inhibition of Cdc42. These results suggest that Cdc42 and RhoA have opposing roles in regulating cell surface localization of MT1-MMP and MMP-2 activation...
  6. ncbi request reprint Transcriptional up-regulation of endothelial cell matrix metalloproteinase-2 in response to extracellular cues involves GATA-2
    Xiaoyan Han
    School of Kinesiology and Health Sciences, York University, Toronto, Ontario M3J 1P3, Canada
    J Biol Chem 278:47785-91. 2003
    ....
  7. doi request reprint Shear stress-induced Ets-1 modulates protease inhibitor expression in microvascular endothelial cells
    Malgorzata Milkiewicz
    School of Kinesiology and Health Science, York University, Toronto, Ontario, Canada
    J Cell Physiol 217:502-10. 2008
    ..These results suggest that enhanced laminar shear stress may act to preserve the integrity of microvascular walls in part through Ets-1-dependent induction of protease inhibitors...
  8. ncbi request reprint JNK and PI3K differentially regulate MMP-2 and MT1-MMP mRNA and protein in response to actin cytoskeleton reorganization in endothelial cells
    Eric Ispanovic
    School of Kinesiology and Health Sciences, York Univ, 4700 Keele St, Toronto, Ontario, Canada M3J 1P3
    Am J Physiol Cell Physiol 291:C579-88. 2006
    ....
  9. ncbi request reprint Molecular control of capillary growth in skeletal muscle
    Tara L Haas
    Department of Kinesiology and Health Sciences, York University, Toronto, Ontario, Canada
    Can J Appl Physiol 27:491-515. 2002
    ..Determining how specific angiogenic stimuli can initiate unique patterns of capillary growth will provide insight into the complex task of developing effective pro-angiogenic therapies...
  10. ncbi request reprint MAPK signaling regulates endothelial cell assembly into networks and expression of MT1-MMP and MMP-2
    Pamela J Boyd
    School of Kinesiology and Health Sciences, Farquharson Bldg, Rm 341, York University, 4700 Keele St, Toronto, Ontario, Canada M3J 1P3
    Am J Physiol Cell Physiol 288:C659-68. 2005
    ....
  11. ncbi request reprint Regulators of angiogenesis and strategies for their therapeutic manipulation
    Malgorzata Milkiewicz
    School of Kinesiology and Health Sciences, York University, Toronto, ONT M3J 1P3, Canada
    Int J Biochem Cell Biol 38:333-57. 2006
    ....
  12. doi request reprint Differential role of beta-catenin in VEGF and histamine-induced MMP-2 production in microvascular endothelial cells
    Jennifer L Doyle
    Muscle Health Research Centre, York University, Toronto, Ontario, Canada
    J Cell Biochem 107:272-83. 2009
    ..While both VEGF and histamine increase nuclear beta-catenin and MMP-2 production, the role of beta-catenin in MMP-2 regulation differs between the two stimuli...
  13. ncbi request reprint Differential involvement of MMP-2 and VEGF during muscle stretch- versus shear stress-induced angiogenesis
    Irina Rivilis
    Department of Kinesiology and Health Sciences, York University, Toronto, Ontario, Canada M3J 1P3
    Am J Physiol Heart Circ Physiol 283:H1430-8. 2002
    ..Our data suggest that the involvement of MMPs in capillary growth is dependent on the nature of the angiogenic stimulus...
  14. doi request reprint JNK as a positive regulator of angiogenic potential in endothelial cells
    Cassandra Uchida
    School of Kinesiology and Health Sciences, York University, Farquharson Room 341, 4700 Keele Street, Toronto, ON, Canada M3J 1P3
    Cell Biol Int 32:769-76. 2008
    ..Taken together, these results provide evidence that JNK and its downstream target c-jun positively regulate angiogenesis via activation of endothelial cell proliferation, migration and proteolysis...
  15. pmc HIF-1alpha and HIF-2alpha play a central role in stretch-induced but not shear-stress-induced angiogenesis in rat skeletal muscle
    Malgorzata Milkiewicz
    School of Kinesiology and Health Sciences, York University, Toronto, Ontario, Canada
    J Physiol 583:753-66. 2007
    ..Together, these results illustrate that activation of HIF-1alpha and HIF-2alpha contributes significantly to stretch- but not to shear-stress-induced capillary growth...
  16. doi request reprint p38 MAPK activity is stimulated by vascular endothelial growth factor receptor 2 activation and is essential for shear stress-induced angiogenesis
    Eric Gee
    School of Kinesiology and Health Science, Muscle Health Research Centre, York University, Toronto, Ontario, Canada
    J Cell Physiol 222:120-6. 2010
    ..p38 inhibition abolished the increase in capillary to muscle fiber ratio seen after 7 days of prazosin treatment. Our data suggest that p38 activation is necessary for shear stress-dependent angiogenesis...
  17. ncbi request reprint Effect of mechanical stretch on HIF-1{alpha} and MMP-2 expression in capillaries isolated from overloaded skeletal muscles: laser capture microdissection study
    Malgorzata Milkiewicz
    School of Kinesiology and Health Science, York University, Toronto, ON, M3J 1P3, Canada
    Am J Physiol Heart Circ Physiol 289:H1315-20. 2005
    ..05). These findings demonstrate the feasibility of this approach to study angiogenic gene regulation and provide novel evidence of HIF-1alpha induction in stretched capillary endothelial cells...
  18. ncbi request reprint Evolving strategies in manipulating VEGF/VEGFR signaling for the promotion of angiogenesis in ischemic muscle
    C Uchida
    School of Kinesiology and Health Science and Muscle Health Research Centre, York University, ON, Canada
    Curr Pharm Des 15:411-21. 2009
    ....
  19. ncbi request reprint Static strain stimulates expression of matrix metalloproteinase-2 and VEGF in microvascular endothelium via JNK- and ERK-dependent pathways
    Malgorzata Milkiewicz
    Department of Laboratory Diagnostics and Molecular Medicine, Pomeranian Medical University, Szczecin, Poland
    J Cell Biochem 100:750-61. 2007
    ..Our results demonstrate that differential regulation of MMP-2 and VEGF by MAPK signal pathways contribute to stretch-induced activation of microvascular endothelial cells...