Research Topics
| Logan W DonaldsonSummaryAffiliation: York University Country: Canada Publications
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Detail Information
Publications
The NMR structure of the Staphylococcus aureus response regulator VraR DNA binding domain reveals a dynamic relationship between it and its associated receiver domainLogan W Donaldson
Department of Biology, York University, 4700 Keele Street, Toronto, Ontario M3J 1P3, Canada
Biochemistry 47:3379-88. 2008..Of note, the DBD alone denatured at a temperature that was 21 degrees C higher than that of the full-length protein. Thus, the DBD appears to be thermodynamically and structurally sensitive to state of the receiver domain...- Solution structure of the dimeric zinc binding domain of the chaperone ClpXLogan W Donaldson
Department of Biology, York University, Toronto, Ontario M3J 1P3, Canada
J Biol Chem 278:48991-6. 2003..However, the dimeric ZBD structure is not related to any protein structure in the Protein Data Bank. A trimer-of-dimers model of ZBD is presented, which might reflect the closed state of the ClpX hexamer... - Saccharomyces cerevisiae Ste50 binds the MAPKKK Ste11 through a head-to-tail SAM domain interactionJamie J Kwan
Department of Biology, York University, 4700 Keele Street, Toronto, Ont, Canada M3J 1P3
J Mol Biol 356:142-54. 2006..Yeast bearing mutations that prevented the heterotypic Ste11-Ste50 association in vitro presented signaling defects in the mating and high-osmolarity growth pathways... - The solution structure of the C-terminal Ig-like domain of the bacteriophage ? tail tube proteinLisa G Pell
Department of Biochemistry, Faculty of Medicine, University of Toronto, Medical Sciences Building, Toronto, ON, Canada
J Mol Biol 403:468-79. 2010..Bioinformatics analyses have identified two conserved clusters of residues on the surface of gpV(C) that may be important in mediating the function of this domain... - RNA recognition by the Vts1p SAM domainPhilip E Johnson
Department of Chemistry, York University, 4700 Keele Street, Toronto, Ontario, Canada, M3J 1P3
Nat Struct Mol Biol 13:177-8. 2006..Here, we present the NMR structures of the Vts1p-SRE complex and the free SRE. Structural highlights include the direct recognition of a guanine base and the formation or stabilization of a base pair in the SRE loop... - Solution structure of the carboxy-terminal Tudor domain from human CoilinRiya Shanbhag
Department of Biology, York University, Toronto, ON, Canada
FEBS Lett 584:4351-6. 2010..Tudor domains have been noted previously to bind DNA, RNA and modified amino acids. The absence of these sequence and structural signatures in the Coilin Tudor domain supporting these established functions suggests an alternative role... - The NMR structure of the murine DLC2 SAM domain reveals a variant fold that is similar to a four-helix bundleJamie J Kwan
Department of Biology, York University, Toronto, Ontario, Canada
BMC Struct Biol 7:34. 2007..DLC2 is characterized by a SAM (sterile alpha motif) domain, a Rho GTPase activating protein (GAP) domain, and a START lipid transfer domain... - The phage lambda major tail protein structure reveals a common evolution for long-tailed phages and the type VI bacterial secretion systemLisa G Pell
Department of Biochemistry, University of Toronto, Medical Sciences Building, Toronto, ON M5S 1A8, Canada
Proc Natl Acad Sci U S A 106:4160-5. 2009..Using Hcp1 as a model, we propose a polymerization mechanism for gpV involving several disorder-to-order transitions... - The NMR and X-ray structures of the Saccharomyces cerevisiae Vts1 SAM domain define a surface for the recognition of RNA hairpinsTzvi Aviv
Program in Molecular Biology and Cancer, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ont, Canada
J Mol Biol 356:274-9. 2006..Amide chemical shift changes map the RNA-binding site to a shallow, basic patch at the junction of helix alpha5 and the loop connecting helices alpha1 and alpha2... - A nuclear localization signal at the SAM-SAM domain interface of AIDA-1 suggests a requirement for domain uncoupling prior to nuclear importArwa Kurabi
Department of Biology, York University, Toronto, Ontario, Canada
J Mol Biol 392:1168-77. 2009..An observed disparity between the thermal stabilities of the two SAM domains suggests a mechanism whereby the second SAM domain decouples from the first SAM domain to facilitate translocation of AIDA-1 to the nucleus... - The NMR structure of the gpU tail-terminator protein from bacteriophage lambda: identification of sites contributing to Mg(II)-mediated oligomerization and biological functionLizbeth Edmonds
Department of Biology, York University, 4700 Keele Street, Canada M3J 1P3
J Mol Biol 365:175-86. 2007..Furthermore, substitutions at these sites abolished the biological activity of gpU... - The solution structure of the S.cerevisiae Ste11 MAPKKK SAM domain and its partnership with Ste50Jamie J Kwan
Department of Biology, York University, 4700 Keele Street, Toronto, Ontario, Canada M3J 1P3
J Mol Biol 342:681-93. 2004..Yeast expressing full-length Ste11-I59R could neither respond to mating pheromone nor thrive in high salt media-demonstrating that the interaction between Ste11 and Ste50 SAM domains is a prerequisite for key signal transduction events... - The structural and dynamic basis of Ets-1 DNA binding autoinhibitionGregory M Lee
Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada
J Biol Chem 280:7088-99. 2005..Ets-1 autoinhibition illustrates how conformational equilibria within structural domains can regulate macromolecular interactions... - Structure of a regulatory complex involving the Abl SH3 domain, the Crk SH2 domain, and a Crk-derived phosphopeptideLogan W Donaldson
Department of Molecular and Medical Genetics, University of Toronto, Toronto, ON, Canada M5S 1A8
Proc Natl Acad Sci U S A 99:14053-8. 2002..This complex between the Abl SH3 domain, Crk SH2 domain, and Crk phosphopeptide is an example of the extremely modular nature of regulatory proteins that provides a rich repertoire of mechanisms for control of biological function...