Lakshmi N Yatham

Summary

Country: Canada

Publications

  1. ncbi request reprint Atypical antipsychotics for bipolar disorder
    Lakshmi N Yatham
    Mood Disorders Clinical Research Unit, University of British Columbia, Room 2C7 2255 Wesbrook Mall, Vancouver, BC V6T 2A1, Canada
    Psychiatr Clin North Am 28:325-47. 2005
  2. doi request reprint A clinical review of aripiprazole in bipolar depression and maintenance therapy of bipolar disorder
    Lakshmi N Yatham
    UBC Department of Psychiatry, The University of British Columbia, UBC Hospital, Vancouver, BC, Canada
    J Affect Disord 128:S21-8. 2011
  3. doi request reprint Efficacy of aripiprazole versus placebo as adjuncts to lithium or valproate in relapse prevention of manic or mixed episodes in bipolar I patients stratified by index manic or mixed episode
    Lakshmi N Yatham
    Department of Psychiatry, University of British Columbia, 2255 Westbrook Mall, Vancouver, British Columbia, Canada
    J Affect Disord 147:365-72. 2013
  4. doi request reprint Positron emission tomography study of the effects of tryptophan depletion on brain serotonin(2) receptors in subjects recently remitted from major depression
    Lakshmi N Yatham
    Mood Disorders Program, Department of Psychiatry, The University of British Columbia, Vancouver, Canada
    Arch Gen Psychiatry 69:601-9. 2012
  5. doi request reprint Effect of electroconvulsive therapy on brain 5-HT(2) receptors in major depression
    Lakshmi N Yatham
    UBC Department of Psychiatry, The University of British Columbia, UBC Hospital, 2255 Wesbrook Mall, Vancouver, BC V6T2A1, Canada
    Br J Psychiatry 196:474-9. 2010
  6. doi request reprint Brain serotonin-2 receptors in acute mania
    Lakshmi N Yatham
    Mood Disorders Program, University of British Columbia, Vancouver, Canada
    Br J Psychiatry 196:47-51. 2010
  7. ncbi request reprint Course and outcome after the first manic episode in patients with bipolar disorder: prospective 12-month data from the Systematic Treatment Optimization Program For Early Mania project
    Lakshmi N Yatham
    Mood Disorders Program, Department of Psychiatry, University of British Columbia, Vancouver, British Columbia V6T 2A1
    Can J Psychiatry 54:105-12. 2009
  8. ncbi request reprint Canadian Network for Mood and Anxiety Treatments (CANMAT) guidelines for the management of patients with bipolar disorder: update 2007
    Lakshmi N Yatham
    Department of Psychiatry, University of British Columbia, 2255 Wesbrook Mall, Vancouver, BC, Canada
    Bipolar Disord 8:721-39. 2006
  9. ncbi request reprint Canadian Network for Mood and Anxiety Treatments (CANMAT) guidelines for the management of patients with bipolar disorder: consensus and controversies
    Lakshmi N Yatham
    Department of Psychiatry, University of British Columbia, Vancouver, BC, Canada
    Bipolar Disord 7:5-69. 2005
  10. doi request reprint Canadian Network for Mood and Anxiety Treatments (CANMAT) and International Society for Bipolar Disorders (ISBD) collaborative update of CANMAT guidelines for the management of patients with bipolar disorder: update 2009
    Lakshmi N Yatham
    Department of Psychiatry, University of British Columbia, 2255 Wesbrook Mall, Vancouver, BC V6T 2A1, Canada
    Bipolar Disord 11:225-55. 2009

Detail Information

Publications74

  1. ncbi request reprint Atypical antipsychotics for bipolar disorder
    Lakshmi N Yatham
    Mood Disorders Clinical Research Unit, University of British Columbia, Room 2C7 2255 Wesbrook Mall, Vancouver, BC V6T 2A1, Canada
    Psychiatr Clin North Am 28:325-47. 2005
    ..Overall, the atypical antipsychotic agents as a group represent an effective and relatively safe addition to the armamentarium for the treatment of bipolar disorder...
  2. doi request reprint A clinical review of aripiprazole in bipolar depression and maintenance therapy of bipolar disorder
    Lakshmi N Yatham
    UBC Department of Psychiatry, The University of British Columbia, UBC Hospital, Vancouver, BC, Canada
    J Affect Disord 128:S21-8. 2011
    ..Aripiprazole is FDA approved for the treatment of acute mania. This paper reviews current data on the efficacy of aripiprazole in the treatment of acute bipolar depression and in maintenance therapy of bipolar disorder...
  3. doi request reprint Efficacy of aripiprazole versus placebo as adjuncts to lithium or valproate in relapse prevention of manic or mixed episodes in bipolar I patients stratified by index manic or mixed episode
    Lakshmi N Yatham
    Department of Psychiatry, University of British Columbia, 2255 Westbrook Mall, Vancouver, British Columbia, Canada
    J Affect Disord 147:365-72. 2013
    ..This post-hoc analysis examined the maintenance effect of aripiprazole in combination with lithium or valproate in subpopulations of patients entering a relapse prevention study with either manic or mixed bipolar episodes...
  4. doi request reprint Positron emission tomography study of the effects of tryptophan depletion on brain serotonin(2) receptors in subjects recently remitted from major depression
    Lakshmi N Yatham
    Mood Disorders Program, Department of Psychiatry, The University of British Columbia, Vancouver, Canada
    Arch Gen Psychiatry 69:601-9. 2012
    ..We hypothesized that downregulation of brain serotonin(2) receptors might be a compensatory mechanism that prevents some patients from becoming depressed with tryptophan depletion...
  5. doi request reprint Effect of electroconvulsive therapy on brain 5-HT(2) receptors in major depression
    Lakshmi N Yatham
    UBC Department of Psychiatry, The University of British Columbia, UBC Hospital, 2255 Wesbrook Mall, Vancouver, BC V6T2A1, Canada
    Br J Psychiatry 196:474-9. 2010
    ..Positron emission tomography (PET) studies in individuals with depression confirmed that antidepressant medications reduce brain 5-HT(2) receptors, but the effects of ECT on these receptors in individuals with depression are unknown...
  6. doi request reprint Brain serotonin-2 receptors in acute mania
    Lakshmi N Yatham
    Mood Disorders Program, University of British Columbia, Vancouver, Canada
    Br J Psychiatry 196:47-51. 2010
    ..Although 5-hydroxytryptamine (5-HT) has been implicated in mania, the precise alterations in the 5-HT system remain elusive...
  7. ncbi request reprint Course and outcome after the first manic episode in patients with bipolar disorder: prospective 12-month data from the Systematic Treatment Optimization Program For Early Mania project
    Lakshmi N Yatham
    Mood Disorders Program, Department of Psychiatry, University of British Columbia, Vancouver, British Columbia V6T 2A1
    Can J Psychiatry 54:105-12. 2009
    ..To describe clinical characteristics, course, and outcome during a 1-year period after the first manic episode in patients with bipolar disorder (BD)...
  8. ncbi request reprint Canadian Network for Mood and Anxiety Treatments (CANMAT) guidelines for the management of patients with bipolar disorder: update 2007
    Lakshmi N Yatham
    Department of Psychiatry, University of British Columbia, 2255 Wesbrook Mall, Vancouver, BC, Canada
    Bipolar Disord 8:721-39. 2006
    ..The importance of comorbid psychiatric and medical conditions cannot be understated, and this update provides an expanded look at the prevalence, impact and management of comorbid conditions in patients with bipolar disorder...
  9. ncbi request reprint Canadian Network for Mood and Anxiety Treatments (CANMAT) guidelines for the management of patients with bipolar disorder: consensus and controversies
    Lakshmi N Yatham
    Department of Psychiatry, University of British Columbia, Vancouver, BC, Canada
    Bipolar Disord 7:5-69. 2005
    ..These guidelines also discuss issues related to bipolar disorder in women and those with comorbidity and include a section on safety and monitoring...
  10. doi request reprint Canadian Network for Mood and Anxiety Treatments (CANMAT) and International Society for Bipolar Disorders (ISBD) collaborative update of CANMAT guidelines for the management of patients with bipolar disorder: update 2009
    Lakshmi N Yatham
    Department of Psychiatry, University of British Columbia, 2255 Wesbrook Mall, Vancouver, BC V6T 2A1, Canada
    Bipolar Disord 11:225-55. 2009
    ..Bipolar II disorder is frequently overlooked in treatment guidelines, but has an important clinical impact on patients' lives. This update provides an expanded look at bipolar II disorder...
  11. ncbi request reprint A positron emission tomography study of the effects of treatment with valproate on brain 5-HT2A receptors in acute mania
    Lakshmi N Yatham
    Division of Mood Disorders, University of British Columbia, Vancouver, BC, Canada
    Bipolar Disord 7:53-7. 2005
    ..To examine the effects of treatment with valproate on brain 5-HT2A receptors in acute manic patients using positron emission tomography (PET) and [18F]-setoperone...
  12. doi request reprint Weight gain, obesity, and metabolic indices following a first manic episode: prospective 12-month data from the Systematic Treatment Optimization Program for Early Mania (STOP-EM)
    David J Bond
    Mood Disorders Centre, University of British Columbia, Room 2C7 2255 Wesbrook Mall, Vancouver, British Columbia, Canada
    J Affect Disord 124:108-17. 2010
    ..However, these reports are limited by retrospective or cross-sectional designs, and the assessment of patients with lengthy illnesses. Prospective data, and data on weight gain early in the course of BD, are lacking...
  13. ncbi request reprint PET study of the effects of valproate on dopamine D(2) receptors in neuroleptic- and mood-stabilizer-naive patients with nonpsychotic mania
    Lakshmi N Yatham
    Mood Disorders Clinical Research Unit, University of British Columbia, 2255 Wesbrook Mall, Vancouver, BC, Canada V6T 2A1
    Am J Psychiatry 159:1718-23. 2002
    ..The purpose of this study was to further examine D(2) receptor density in a larger sample of nonpsychotic manic patients by using positron emission tomography (PET) and [(11)C]raclopride...
  14. ncbi request reprint Newer anticonvulsants in the treatment of bipolar disorder
    Lakshmi N Yatham
    Division of Mood Disorders, University of British Columbia, Vancouver, British Columbia, Canada
    J Clin Psychiatry 65:28-35. 2004
    ..This article summarizes current evidence from trials of anticonvulsants in bipolar disorder and makes recommendations for their clinical use...
  15. ncbi request reprint PET study of [(18)F]6-fluoro-L-dopa uptake in neuroleptic- and mood-stabilizer-naive first-episode nonpsychotic mania: effects of treatment with divalproex sodium
    Lakshmi N Yatham
    Department of Psychiatry, University of British Columbia, Vancouver, Canada
    Am J Psychiatry 159:768-74. 2002
    ....
  16. doi request reprint Comparison of neuropsychological effects of adjunctive risperidone or quetiapine in euthymic patients with bipolar I disorder
    Jan Marie Kozicky
    Department of Psychiatry, University of British Columbia, Vancouver, BC, Canada
    Int Clin Psychopharmacol 27:91-9. 2012
    ....
  17. pmc 3-Nitrotyrosine and glutathione antioxidant system in patients in the early and late stages of bipolar disorder
    Ana Cristina Andreazza
    Department of Psychiatry, University of British Columbia, BC, Canada
    J Psychiatry Neurosci 34:263-71. 2009
    ....
  18. doi request reprint The association of elevated body mass index with reduced brain volumes in first-episode mania
    David J Bond
    Mood Disorders Centre, University of British Columbia, Vancouver, Canada
    Biol Psychiatry 70:381-7. 2011
    ..In the general population, obesity is associated with reduced total brain volume (TBV) and gray matter volume (GMV), but the neurobiology of obesity in BD has not been investigated...
  19. ncbi request reprint A double blind, randomized, placebo-controlled trial of quetiapine as an add-on therapy to lithium or divalproex for the treatment of bipolar mania
    Lakshmi N Yatham
    Division of Mood Disorders, University of British Columbia, UBC Hospital, Vancouver, British Columbia, Canada
    Int Clin Psychopharmacol 22:212-20. 2007
    ..Overall, the combination of quetiapine with lithium or divalproex was well tolerated...
  20. doi request reprint Brain-derived neurotrophic factor and inflammatory markers in patients with early- vs. late-stage bipolar disorder
    Márcia Kauer-Sant'Anna
    Mood Disorders Centre, Department of Psychiatry, University of British Columbia, Vancouver, Canada
    Int J Neuropsychopharmacol 12:447-58. 2009
    ..Failure of inflammatory defences in the late stage of the disorder may account for reduction in BDNF and continued elevations in cytokines; thus these may have the potential to serve as markers of illness progression in BD...
  21. ncbi request reprint Risperidone plus lithium versus risperidone plus valproate in acute and continuation treatment of mania
    Lakshmi N Yatham
    University of British Columbia, Vancouver, British Columbia Janssen Ortho Inc, Toronto, Canada
    Int Clin Psychopharmacol 19:103-9. 2004
    ..These data suggest that risperidone can be safely combined with either lithium or valproate, and that the efficacy is similar regardless of the mood stabilizer used...
  22. doi request reprint Functional outcomes in first-episode patients with bipolar disorder: a prospective study from the Systematic Treatment Optimization Program for Early Mania project
    Márcia Kauer-Sant'Anna
    Department of Psychiatry, Mood Disorders Centre, University of British Columbia, Vancouver, Canada
    Compr Psychiatry 50:1-8. 2009
    ..However, there is a relative dearth of research on functional outcomes and their predictors in first-episode manic patients from prospective studies early in the course of bipolar disorder...
  23. doi request reprint Canadian Network for Mood and Anxiety Treatments (CANMAT) and International Society for Bipolar Disorders (ISBD) collaborative update of CANMAT guidelines for the management of patients with bipolar disorder: update 2013
    Lakshmi N Yatham
    Department of Psychiatry, University of British Columbia, Vancouver, BC, Canada
    Bipolar Disord 15:1-44. 2013
    ..Asenapine alone or as adjunctive therapy have been added as third-line options...
  24. ncbi request reprint The CANMAT task force recommendations for the management of patients with mood disorders and comorbid anxiety disorders
    Ayal Schaffer
    Mood and Anxiety Disorders Program, Sunnybrook Health Sciences Centre, Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada
    Ann Clin Psychiatry 24:6-22. 2012
    ..This article is part of a set of Canadian Network for Mood and Anxiety Treatments (CANMAT) Comorbidity Task Force papers...
  25. doi request reprint The relationship between clinical outcomes and quality of life in first-episode mania: a longitudinal analysis
    Erin E Michalak
    Department of Psychiatry, University of British Columbia, Vancouver, BC, Canada
    Bipolar Disord 15:188-98. 2013
    ..Here, we report on QoL and symptomatic outcomes over a 1.5-year period in a Canadian sample of first-episode mania patients...
  26. ncbi request reprint Atypical antipsychotics in bipolar depression: potential mechanisms of action
    Lakshmi N Yatham
    Department of Psychiatry, The University of British Columbia, UBC Hospital, Vancouver, Canada
    J Clin Psychiatry 66:40-8. 2005
    ..Further studies should be conducted to examine these hypotheses...
  27. ncbi request reprint Oxcarbazepine in the treatment of bipolar disorder: a review
    Wetid Pratoomsri
    Mood Disorders Centre of Excellence, University of British Columbia, Vancouver
    Can J Psychiatry 51:540-5. 2006
    ..To review the data on the efficacy of oxcarbazepine (OXC) in bipolar disorder (BD) and to provide recommendations for clinicians on the use of this medication in treating BD...
  28. ncbi request reprint Risperidone in acute and continuation treatment of mania
    Lakshmi N Yatham
    Department of Psychiatry, University of British Columbia, Vancouver, Canada
    Int Clin Psychopharmacol 18:227-35. 2003
    ..Risperidone add-on does not induce depressive symptoms and, furthermore, risperidone may have efficacy in treating comorbid depressive symptoms in bipolar patients...
  29. ncbi request reprint Oral methylphenidate fails to elicit significant changes in extracellular putaminal dopamine levels in Parkinson's disease patients: positron emission tomographic studies
    Kaveh M Koochesfahani
    Pacific Parkinson s Research Centre, University of British Columbia, Vancouver, British Columbia, Canada
    Mov Disord 21:970-5. 2006
    ..Our data provide in vivo neurochemical support for the lack of clinical efficacy following MP in PD patients and are also in keeping with reduced DA release following amphetamine in PD subjects...
  30. pmc A new clinical rating scale for work absence and productivity: validation in patients with major depressive disorder
    Raymond W Lam
    Department of Psychiatry, University of BC, Mood Disorders Centre, UBC Hospital, Vancouver, Canada
    BMC Psychiatry 9:78. 2009
    ..This study seeks to validate the Lam Employment Absence and Productivity Scale (LEAPS), a 10-item self-report questionnaire that takes 3-5 minutes to complete...
  31. ncbi request reprint Generic and health-related quality of life in patients with seasonal and nonseasonal depression
    Erin E Michalak
    Division of Clinical Neuroscience, Department of Psychiatry, University of British Columbia, 2255 Wesbrook Mall, Vancouver, BC, Canada V6T 2A1
    Psychiatry Res 128:245-51. 2004
    ..Future research is required to determine whether perceived QoL is improved by treatment interventions for seasonal depression such as light therapy or antidepressant medication...
  32. ncbi request reprint Pharmacotherapy of bipolar II disorder: a critical review of current evidence
    George Hadjipavlou
    Department of Psychiatry, University of British Columbia, Vancouver, Canada
    Bipolar Disord 6:14-25. 2004
    ..To address the growing need to find effective treatment strategies for patients with BP II, this article identifies and summarizes available published evidence specific to the pharmacotherapy of BP II...
  33. ncbi request reprint A magnetic resonance imaging study of mood stabilizer- and neuroleptic-naïve first-episode mania
    Lakshmi N Yatham
    Division of Mood Disorders, University of British Columbia, Vancouver, BC, Canada
    Bipolar Disord 9:693-7. 2007
    ..Studies in first-episode (FE) manic patients have the potential to provide answers to these questions...
  34. ncbi request reprint Quality of life in patients with bipolar I depression: data from 920 patients
    Lakshmi N Yatham
    The University of British Columbia, Vancouver, BC, Canada
    Bipolar Disord 6:379-85. 2004
    ..To determine the impact of acute depression on quality of life (QOL) in patients with bipolar I disorder and to compare these results with published data on QOL in patients with unipolar depression...
  35. doi request reprint Effects of combined pharmacotherapy and psychotherapy for improving work functioning in major depressive disorder
    Raymond W Lam
    Raymond W Lam, MD, Department of Psychiatry, University of British Columbia, UBC Hospital, Vancouver, British Columbia Sagar V Parikh, MD, Department of Psychiatry, University of Toronto, University Health Network, Toronto, Ontario Rajamannar Ramasubbu, MD, Department of Psychiatry, University of Calgary, Calgary, Alberta Erin E Michalak, PhD, Edwin M Tam, MD, Auby Axler, MD, Lakshmi N Yatham, MBBS, Department of Psychiatry, University of British Columbia, UBC Hospital, Vancouver, British Columbia Sidney H Kennedy, MD, Department of Psychiatry, University of Toronto, University Health Network, Toronto, Ontario Chinnapalli V Manjunath, MD, Department of Psychiatry, University of British Columbia, Surrey Memorial Hospital, Surrey, British Columbia, Canada
    Br J Psychiatry 203:358-65. 2013
    ..Major depressive disorder is associated with significant impairment in occupational functioning and reduced productivity, which represents a large part of the overall burden of depression...
  36. ncbi request reprint Citalopram and bupropion-SR: combining versus switching in patients with treatment-resistant depression
    Raymond W Lam
    Division of Clinical Neuroscience, Department of Psychiatry, University of British Columbia, 2255 Wesbrook Mall, Vancouver, BC, V6T 2A1 Canada
    J Clin Psychiatry 65:337-40. 2004
    ..In this study, we compared the effects of combining citalopram and bupropion-SR versus switching to the other monotherapy in treatment-resistant depression...
  37. ncbi request reprint Bipolar disorder and quality of life: a patient-centered perspective
    Erin E Michalak
    Division of Mood Disorders, Department of Psychiatry, University of British Columbia, Vancouver, BC V6T 2A1, Canada
    Qual Life Res 15:25-37. 2006
    ..We report here on a series of in-depth qualitative interviews we conducted as part of the item generation phase for a disease-specific scale to assess QoL in BD...
  38. ncbi request reprint Polytherapy in bipolar disorder
    Daniel Lin
    Department of Psychiatry, University of British Columbia, Vancouver, Canada
    CNS Drugs 20:29-42. 2006
    ..Similarly, the combination of lithium or valproate plus olanzapine seems to be more effective than monotherapy with a mood stabiliser in preventing manic episodes...
  39. pmc Quality of life in bipolar disorder: a review of the literature
    Erin E Michalak
    Department of Psychiatry, University of British Columbia, Vancouver, Canada
    Health Qual Life Outcomes 3:72. 2005
    ..We identified several important avenues for future research, including a need for more assessment of QoL in hypo/manic patients, more longitudinal research and the development of a disease-specific measure of QoL for patients with BD...
  40. ncbi request reprint Bipolar depression: criteria for treatment selection, definition of refractoriness, and treatment options
    Lakshmi N Yatham
    Department of Psychiatry, The University of British Columbia, Vancouver, British Columbia, Canada
    Bipolar Disord 5:85-97. 2003
    ..This paper reviews controlled studies of bipolar depression, outlines criteria for choosing treatment, defines refractoriness in bipolar depression, and provides options for treatment of refractory bipolar depression...
  41. ncbi request reprint Antidepressant-associated mood elevations in bipolar II disorder compared with bipolar I disorder and major depressive disorder: a systematic review and meta-analysis
    David J Bond
    Research and International Affairs, Mood Disorders Centre, Department of Psychiatry, University of British Columbia, Room 2C7, 2255 Wesbrook Mall, Vancouver, BC V6T 2A1 Canada
    J Clin Psychiatry 69:1589-601. 2008
    ..The risk of antidepressant-associated mood elevations (AAME) in bipolar II disorder relative to bipolar I disorder and MDD is unknown...
  42. ncbi request reprint Perceived quality of life in patients with bipolar disorder. Does group psychoeducation have an impact?
    Erin E Michalak
    Department of Psychiatry, University of British Columbia, Vancouver
    Can J Psychiatry 50:95-100. 2005
    ..We aimed to assess the impact of a time-limited psychoeducation (PE) group therapy upon perceived QoL among patients with BD...
  43. doi request reprint Neurocognitive functioning in patients with bipolar I disorder recently recovered from a first manic episode
    Ivan J Torres
    Research Department, Riverview Hospital, British Columbia Mental Health and Addictions Services, Coquitlam, British Columbia, Canada
    J Clin Psychiatry 71:1234-42. 2010
    ..The purpose of this study was to determine whether neuropsychological impairments are present in clinically stable patients with bipolar disorder shortly after resolution of their first manic episode...
  44. doi request reprint The association of weight gain with mood symptoms and functional outcomes following a first manic episode: prospective 12-month data from the Systematic Treatment Optimization Program for Early Mania (STOP-EM)
    David J Bond
    Department of Psychiatry, Mood Disorders Centre, University of British Columbia, Vancouver, BC, Canada
    Bipolar Disord 12:616-26. 2010
    ..Obesity in the general population is also consistently associated with functional impairment, but the relationship between weight gain and functional outcomes in BD-I has received little attention...
  45. doi request reprint Brain glutamate levels measured by magnetic resonance spectroscopy in patients with bipolar disorder: a meta-analysis
    Alexandre Duarte Gigante
    Department of Psychiatry, University of British Columbia, Vancouver, BC, Canada
    Bipolar Disord 14:478-87. 2012
    ..The objective of this paper was to conduct a systematic review and meta-analysis of the literature on brain glutamate/glutamine in BD as measured by ¹H-MRS...
  46. doi request reprint Prefrontal cortex glutathione S-transferase levels in patients with bipolar disorder, major depression and schizophrenia
    Jeremy W Gawryluk
    Department of Psychiatry, University of British Columbia, Vancouver, BC, Canada
    Int J Neuropsychopharmacol 14:1069-74. 2011
    ..These data suggest that GST Mu may be a target for mood stabilizers...
  47. ncbi request reprint Oxcarbazepine add-on in the treatment of refractory bipolar disorder
    Wetid Pratoomsri
    Mood Disorders Clinical Research Unit, The University of British Columbia, Vancouver, BC, Canada
    Bipolar Disord 7:37-42. 2005
    ..To assess the effectiveness and safety of oxcarbazepine (OXC) in bipolar disorder (BD) and related conditions...
  48. doi request reprint Divalproex sodium versus placebo in the treatment of acute bipolar depression: a systematic review and meta-analysis
    David J Bond
    Mood Disorders Centre, University of British Columbia, Room 2C7 2255 Wesbrook Mall, Vancouver, BC Canada V6T 2A1
    J Affect Disord 124:228-34. 2010
    ....
  49. ncbi request reprint Diagnosis and management of patients with bipolar II disorder
    Lakshmi N Yatham
    Division of Mood Disorders, University of British Columbia, Vancouver, Canada
    J Clin Psychiatry 66:13-7. 2005
    ..Hypomania will likely respond to monotherapy with antimanic agents. Adjunctive psychosocial treatments may provide additional benefit in patients with bipolar II disorder...
  50. ncbi request reprint Lamotrigine for bipolar disorder: translating research into clinical practice
    Jonathan Fung
    Department of Psychiatry, University of British Columbia, Vancouver, Canada
    Expert Rev Neurother 4:363-70. 2004
    ..Practical recommendations regarding titration and the management of rash are offered...
  51. ncbi request reprint Quetiapine versus placebo in combination with lithium or divalproex for the treatment of bipolar mania
    Lakshmi N Yatham
    Department of Psychiatry, University of British Columbia, Vancouver, BC, Canada
    J Clin Psychopharmacol 24:599-606. 2004
    ..Quetiapine, in combination with lithium or divalproex, is well tolerated and has superior efficacy to lithium or divalproex alone in the treatment of bipolar mania...
  52. ncbi request reprint Acute and maintenance treatment of bipolar mania: the role of atypical antipsychotics
    Lakshmi N Yatham
    Mood Disorders Clinical Research Unit, The University of British Columbia, Vancouver, BC, V6T 2A1, Canada
    Bipolar Disord 5:7-19. 2003
    ..The atypical antipsychotics represent an effective and relatively safe addition to our armamentarium for the treatment of bipolar disorder...
  53. doi request reprint Relationship between frontostriatal morphology and executive function deficits in bipolar I disorder following a first manic episode: data from the Systematic Treatment Optimization Program for Early Mania (STOP-EM)
    Jan Marie Kozicky
    Department of Psychiatry, University of British Columbia, Vancouver, BC, Canada
    Bipolar Disord 15:657-68. 2013
    ..Despite advances in knowledge regarding the neural basis of executive functions in healthy subjects, research into morphological abnormalities underlying the deficits in BD-I is lacking...
  54. ncbi request reprint Bipolar II disorder: an overview of recent developments
    George Hadjipavlou
    Department of Psychiatry, University of British Columbia, Vancouver
    Can J Psychiatry 49:802-12. 2004
    ..Recent research on the epidemiology, clinical course, diagnosis, and treatment of bipolar II disorder (BD II) stands to have a considerable impact on clinical practice. This paper reviews these developments...
  55. ncbi request reprint Mood stabilization and the role of antipsychotics
    Lakshmi N Yatham
    Mood Disorders Clinical Research Unit, Department of Psychiatry, University of British Columbia, Vancouver, Canada
    Int Clin Psychopharmacol 17:S21-7. 2002
    ..This article will review the results from open and double-blind studies with quetiapine, ziprasidone, risperidone and olanzapine in the management of bipolar disorder...
  56. ncbi request reprint A comparison of personality function among patients with seasonal depression, nonseasonal depression, and nonclinical participants
    Erin E Michalak
    Department of Psychiatry, University of British Columbia, Vancouver, Canada
    J Pers Disord 18:448-58. 2004
    ..The results demonstrated that the traits associated with seasonal and nonseasonal depression differ in degree, not kind...
  57. pmc Immediate effects of risperidone on cerebral activity in healthy subjects: a comparison with subjects with first-episode schizophrenia
    Carol J Lane
    Department of Psychiatry, University of British Columbia, Vancouver, BC
    J Psychiatry Neurosci 29:30-7. 2004
    ....
  58. doi request reprint Sex differences in cognitive functioning in patients with bipolar disorder who recently recovered from a first episode of mania: Data from the Systematic Treatment Optimization Program for Early Mania (STOP-EM)
    Joana Bücker
    Department of Psychiatry, University of British Columbia, 2255 Wesbrook Mall, Vancouver, BC, Canada V6T2A1 Bipolar Disorder Program and Laboratory of Molecular Psychiatry, National Institute for Translational Medicine, INCT TM Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
    J Affect Disord 155:162-8. 2014
    ....
  59. doi request reprint The International Society for Bipolar Disorders-Battery for Assessment of Neurocognition (ISBD-BANC)
    Lakshmi N Yatham
    Department of Psychiatry, University of British Columbia, Vancouver, British Columbia, Canada
    Bipolar Disord 12:351-63. 2010
    ....
  60. pmc Which depressive symptoms and medication side effects are perceived by patients as interfering most with occupational functioning?
    Raymond W Lam
    Mood and Anxiety Disorders Program, Department of Psychiatry, Mood Disorders Centre, UBC Hospital, University of British Columbia, Vancouver, BC, Canada V6T 2A1
    Depress Res Treat 2012:630206. 2012
    ..These factors should be considered in treatment selection (e.g., in the choice of antidepressant) in working patients with MDD...
  61. doi request reprint Oxidative stress markers in bipolar disorder: a meta-analysis
    Ana C Andreazza
    Department of Psychiatry, University of British Columbia, Vancouver, BC, Canada
    J Affect Disord 111:135-44. 2008
    ..In the present investigation, we conducted a meta-analysis of studies that evaluated markers of oxidative stress in individuals with BD, as compared to healthy controls...
  62. doi request reprint Efficacy of second generation antipsychotics in treating acute mixed episodes in bipolar disorder: a meta-analysis of placebo-controlled trials
    Kesavan Muralidharan
    Mood Disorders Centre, Department of Psychiatry, University of British Columbia, 2255 Wesbrook Mall, Vancouver BC Canada V6T2A1
    J Affect Disord 150:408-14. 2013
    ..The objective of this meta-analysis was to ascertain the efficacy of SGA, either as mono- and/or adjunctive therapy, in the treatment of acute mixed episodes of BD, compared to placebo...
  63. doi request reprint Morphometric post-mortem studies in bipolar disorder: possible association with oxidative stress and apoptosis
    Alexandre Duarte Gigante
    Department of Psychiatry, University of British Columbia, Vancouver, Canada
    Int J Neuropsychopharmacol 14:1075-89. 2011
    ....
  64. doi request reprint Emotional memory in bipolar disorder
    Márcia Kauer-Sant'Anna
    Mood Disorders Centre, University of British Columbia, 2C7 2255 Wesbrook Mall, Vancouver, Canada V6T 2A1
    Br J Psychiatry 192:458-63. 2008
    ..Cognitive impairment has been well documented in bipolar disorder. However, specific aspects of cognition such as emotional memory have not been examined...
  65. ncbi request reprint The impact of bipolar disorder upon work functioning: a qualitative analysis
    Erin E Michalak
    Division of Mood Disorders, Department of Psychiatry, University of British Columbia, Vancouver, British Columbia, Canada
    Bipolar Disord 9:126-43. 2007
    ..In order to further elucidate the relationship between BD and work, we report here on a series of exploratory qualitative interviews undertaken to develop a disease-specific measure of quality of life in BD...
  66. ncbi request reprint Repetitive transcranial magnetic stimulation for treatment-resistant depression: a systematic review and metaanalysis
    Raymond W Lam
    Division of Clinical Neuroscience, Department of Psychiatry, University of British Columbia, Vancouver, British Columbia
    Can J Psychiatry 53:621-31. 2008
    ..None have specifically examined outcomes in patients with treatment-resistant depression (TRD)...
  67. ncbi request reprint Advances in treatment of mood and anxiety disorders: focus on atypical antipsychotics
    Lakshmi N Yatham
    University of British Columbia, Vancouver, BC
    Bipolar Disord 5:5-6. 2003
  68. ncbi request reprint Third generation anticonvulsants in bipolar disorder: a review of efficacy and summary of clinical recommendations
    Lakshmi N Yatham
    Department of Psychiatry, University of British Columbia, Vancouver, Canada
    J Clin Psychiatry 63:275-83. 2002
    ..To review the literature on efficacy of third generation anticonvulsants for treatment of bipolar disorder and provide clinical recommendations...
  69. pmc Mirtazapine for treatment-resistant depression: a preliminary report
    Dante D C Wan
    Division of Mood Disorders, Department of Psychiatry, University of British Columbia and UBC Hospital, Vancouver, BC
    J Psychiatry Neurosci 28:55-9. 2003
    ..To describe the effectiveness and tolerability of mirtazapine, a noradrenergic and specific serotonergic antidepressant, in the open-label treatment of patients with depression who were resistant to other antidepressant agents...
  70. ncbi request reprint Hard times and good friends: negative life events and social support in patients with seasonal and nonseasonal depression
    Erin E Michalak
    Department of Psychiatry, University of British Columbia UBC Hospital, VCHA, Vancouver, British Columbia
    Can J Psychiatry 49:408-11. 2004
    ..This study aimed to compare baseline levels of negative life events (NLEs) and perceived social support (SS) in patients with seasonal and nonseasonal depression...
  71. ncbi request reprint Does neuroimmune dysfunction mediate seasonal mood changes in winter depression?
    Raymond W Lam
    Division of Clinical Neuroscience, Department of Psychiatry, University of British Columbia UBC, 2255 Wesbrook Mall, Vancouver, BC, Canada V6T 2A1
    Med Hypotheses 63:567-73. 2004
    ..The etiology of winter depression (seasonal affective disorder, or SAD) is not known, but a number of studies have provided support for both photoperiod and neurotransmitter hypotheses...
  72. ncbi request reprint Translating knowledge of genetics and pharmacology into improving everyday practice
    Lakshmi N Yatham
    Department of Psychiatry, University of British Columbia, Vancouver, BC, Canada
    Bipolar Disord 7:13-20. 2005
    ....
  73. ncbi request reprint Efficacy of atypical antipsychotics in mood disorders
    Lakshmi N Yatham
    University of British Columbia, Vancouver, Canada
    J Clin Psychopharmacol 23:S9-14. 2003
    ....
  74. ncbi request reprint The role of novel antipsychotics in bipolar disorders
    Lakshmi N Yatham
    Division of Mood Disorders, University of British Columbia, Vancouver, Canada
    J Clin Psychiatry 63:10-4. 2002
    ..Olanzapine, another novel antipsychotic, is also effective against both manic and depressive symptoms and in the maintenance treatment as indicated by an open-label study. Data on other novel agents are more limited...