J Xiang

Summary

Country: Canada

Publications

  1. ncbi Direct in vivo evidence of CD4+ T cell requirement for CTL response and memory via pMHC-I targeting and CD40L signaling
    Khawaja Ashfaque Ahmed
    Research Unit, Saskatchewan Cancer Agency, Department of Oncology, University of Saskatchewan, Saskatoon, Saskatchewan Canada
    J Leukoc Biol 92:289-300. 2012
  2. ncbi Transgene expression of alpha tumor necrosis factor with mutations D142N and A144R under control of human telomerase reverse transcriptase promoter eradicates well-established tumors and induces long-term antitumor immunity
    J Xiang
    Cancer Research Unit, Saskatchewan Cancer Agency, Departments of Oncology, University of Saskatchewan, Saskatoon, Saskatchewan, Canada
    Cancer Gene Ther 16:430-8. 2009
  3. ncbi Vaccination of fiber-modified adenovirus-transfected dendritic cells to express HER-2/neu stimulates efficient HER-2/neu-specific humoral and CTL responses and reduces breast carcinogenesis in transgenic mice
    S Sas
    Division of Oncology, Cancer Research Unit, Saskatchewan Cancer Agency, University of Saskatchewan, Saskatoon, Saskatchewan, Canada
    Cancer Gene Ther 15:655-66. 2008
  4. ncbi Efficient antitumor immunity derived from maturation of dendritic cells that had phagocytosed apoptotic/necrotic tumor cells
    Z Chen
    Saskatoon Cancer Center, Saskatoon, Saskatchewan, Canada
    Int J Cancer 93:539-48. 2001
  5. ncbi Lymphotactin expression by engineered myeloma cells drives tumor regression: mediation by CD4+ and CD8+ T cells and neutrophils expressing XCR1 receptor
    C M Cairns
    Department of Microbiology, Saskatoon Cancer Center, Saskatoon, Saskatchewan, Canada
    J Immunol 167:57-65. 2001
  6. ncbi DNA array and biological characterization of the impact of the maturation status of mouse dendritic cells on their phenotype and antitumor vaccination efficacy
    Z Chen
    Saskatoon Cancer Center, University of Saskatchewan, Saskatoon, Saskatchewan, S7N 0W0, Canada
    Cell Immunol 214:60-71. 2001
  7. ncbi Engineered CD8+ cytotoxic T cells with fiber-modified adenovirus-mediated TNF-alpha gene transfection counteract immunosuppressive interleukin-10-secreting lung metastasis and solid tumors
    Z Ye
    Research Unit, Health Research Division, Saskatchewan Cancer Agency, Saskatoon, Saskatchewan, Canada
    Cancer Gene Ther 14:661-75. 2007
  8. ncbi Regression of engineered myeloma cells secreting interferon-gamma-inducing factor is mediated by both CD4(+)/CD8(+) T and natural killer cells
    J Xiang
    Departments of Microbiology and Pathology, Saskatoon Cancer Center, College of Medicine, University of Saskatchewan, 20 Campus Drive, Saskatoon, S7N 4H4, Saskatchewan, Canada
    Leuk Res 25:909-15. 2001
  9. ncbi Cancer gene therapy by adenovirus-mediated gene transfer
    Q Wu
    Adenovirus Group, Veterinary Infectious Disease Organization, Saskatchewan Cancer Agency, 20 Campus Drive, Saskatoon, Saskatchewan S7N 4H4, Canada
    Curr Gene Ther 1:101-22. 2001
  10. ncbi HER-2/neu-gene engineered dendritic cell vaccine stimulates stronger HER-2/neu-specific immune responses compared to DNA vaccination
    T Chan
    Cancer Research Unit, Saskatchewan Cancer Agency, University of Saskatchewan, 20 Campus Drive, Saskatoon, Saskatchewan, Canada S7N 4H4
    Gene Ther 13:1391-402. 2006

Collaborators

Detail Information

Publications17

  1. ncbi Direct in vivo evidence of CD4+ T cell requirement for CTL response and memory via pMHC-I targeting and CD40L signaling
    Khawaja Ashfaque Ahmed
    Research Unit, Saskatchewan Cancer Agency, Department of Oncology, University of Saskatchewan, Saskatoon, Saskatchewan Canada
    J Leukoc Biol 92:289-300. 2012
    ....
  2. ncbi Transgene expression of alpha tumor necrosis factor with mutations D142N and A144R under control of human telomerase reverse transcriptase promoter eradicates well-established tumors and induces long-term antitumor immunity
    J Xiang
    Cancer Research Unit, Saskatchewan Cancer Agency, Departments of Oncology, University of Saskatchewan, Saskatoon, Saskatchewan, Canada
    Cancer Gene Ther 16:430-8. 2009
    ..Therefore, AdV(TERT)mTNF-alpha gene therapy may be very useful in the immunotherapy of cancer...
  3. ncbi Vaccination of fiber-modified adenovirus-transfected dendritic cells to express HER-2/neu stimulates efficient HER-2/neu-specific humoral and CTL responses and reduces breast carcinogenesis in transgenic mice
    S Sas
    Division of Oncology, Cancer Research Unit, Saskatchewan Cancer Agency, University of Saskatchewan, Saskatoon, Saskatchewan, Canada
    Cancer Gene Ther 15:655-66. 2008
    ..Therefore, vaccination of fiber-modified adenovirus-transfected DCs to enhance expression of tumor antigens such as HER-2/neu is likely representative of a new direction in DC-based vaccine of breast cancer...
  4. ncbi Efficient antitumor immunity derived from maturation of dendritic cells that had phagocytosed apoptotic/necrotic tumor cells
    Z Chen
    Saskatoon Cancer Center, Saskatoon, Saskatchewan, Canada
    Int J Cancer 93:539-48. 2001
    ..Therefore, DCs that had phagocytosed apoptotic/necrotic tumor cells appear to offer new strategies in DC cancer vaccines...
  5. ncbi Lymphotactin expression by engineered myeloma cells drives tumor regression: mediation by CD4+ and CD8+ T cells and neutrophils expressing XCR1 receptor
    C M Cairns
    Department of Microbiology, Saskatoon Cancer Center, Saskatoon, Saskatchewan, Canada
    J Immunol 167:57-65. 2001
    ..Thus, lymphotactin has natural adjuvant activities that may augment antitumor responses via effects on both T cells and neutrophils and thereby could be important in gene transfer immunotherapies for some cancers...
  6. ncbi DNA array and biological characterization of the impact of the maturation status of mouse dendritic cells on their phenotype and antitumor vaccination efficacy
    Z Chen
    Saskatoon Cancer Center, University of Saskatchewan, Saskatoon, Saskatchewan, S7N 0W0, Canada
    Cell Immunol 214:60-71. 2001
    ..Taken together, our data clearly underscore the critical nature of employing DCs of full maturity for DC-based antitumor vaccination strategies...
  7. ncbi Engineered CD8+ cytotoxic T cells with fiber-modified adenovirus-mediated TNF-alpha gene transfection counteract immunosuppressive interleukin-10-secreting lung metastasis and solid tumors
    Z Ye
    Research Unit, Health Research Division, Saskatchewan Cancer Agency, Saskatoon, Saskatchewan, Canada
    Cancer Gene Ther 14:661-75. 2007
    ..Therefore, CD8+ T cells engineered to secrete TNF-alpha may be useful when designing strategies for adoptive T-cell therapy of solid tumors...
  8. ncbi Regression of engineered myeloma cells secreting interferon-gamma-inducing factor is mediated by both CD4(+)/CD8(+) T and natural killer cells
    J Xiang
    Departments of Microbiology and Pathology, Saskatoon Cancer Center, College of Medicine, University of Saskatchewan, 20 Campus Drive, Saskatoon, S7N 4H4, Saskatchewan, Canada
    Leuk Res 25:909-15. 2001
    ..This study thus highlights the potential utility of IL-18 as an antitumor agent, a role that it can fulfil alone or in combination with other immunomodulatory cytokines such as IL-12...
  9. ncbi Cancer gene therapy by adenovirus-mediated gene transfer
    Q Wu
    Adenovirus Group, Veterinary Infectious Disease Organization, Saskatchewan Cancer Agency, 20 Campus Drive, Saskatoon, Saskatchewan S7N 4H4, Canada
    Curr Gene Ther 1:101-22. 2001
    ..We also discuss the current limitations of the adenoviral vector system and how they may be circumvented in future developments relating to targeted gene delivery...
  10. ncbi HER-2/neu-gene engineered dendritic cell vaccine stimulates stronger HER-2/neu-specific immune responses compared to DNA vaccination
    T Chan
    Cancer Research Unit, Saskatchewan Cancer Agency, University of Saskatchewan, 20 Campus Drive, Saskatoon, Saskatchewan, Canada S7N 4H4
    Gene Ther 13:1391-402. 2006
    ..Therefore, DCs genetically engineered to express tumor antigens such as HER-2/neu represent a new direction in DC vaccine of breast cancer...
  11. ncbi Regression of engineered tumor cells secreting cytokines is related to a shift in host cytokine profile from type 2 to type 1
    J Xiang
    Department of Microbiology, College of Medicine, University of Saskatchewan, Saskatoon, Canada
    J Interferon Cytokine Res 20:349-54. 2000
    ..A better understanding of the mechanisms by which tumor cells modulate the host immune system may result in newer approaches for manipulating host-tumor interactions that favor the development of a protective antitumor immune response...
  12. ncbi Enhanced T-cell immunity induced by dendritic cells with phagocytosis of heat shock protein 70 gene-transfected tumor cells in early phase of apoptosis
    T Chan
    Research Unit, Saskatchewan Cancer Agency, Department of Oncology, College of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada
    Cancer Gene Ther 14:409-20. 2007
    ..These results may have an important impact in designing DC-based antitumor vaccines...
  13. ncbi Adjuvant effect of HER-2/neu-specific adenoviral vector stimulating CD8⁺ T and natural killer cell responses on anti-HER-2/neu antibody therapy for well-established breast tumors in HER-2/neu transgenic mice
    Y Chen
    Cancer Research Unit, Research Division, Saskatchewan Cancer Agency, Saskatoon, Saskatchewan, Canada
    Cancer Gene Ther 18:489-99. 2011
    ....
  14. ncbi Combined CD4+ Th1 effect and lymphotactin transgene expression enhance CD8+ Tc1 tumor localization and therapy
    H Huang
    Department of Oncology, Research Unit, Saskatchewan Cancer Agency, Saskatoon, Saskatchewan, Canada
    Gene Ther 12:999-1010. 2005
    ..This novel therapeutic strategy with enhancement of Tc1 tumor localization in the therapy of well-established tumors may become a tool of considerable conceptual interest in the implementation of future clinical objectives...
  15. ncbi Cloning and expression of functional cDNA genes of a mouse/human chimeric antibody rcM4
    M Boyd
    Saskatoon Cancer Center, Department of Microbiology, University of Saskatchewan, Canada
    Tumori 80:473-9. 1994
    ..They thus have potential utility in the construction of some novel hybrid proteins such as those containing both antitumor immunoglobulins and cytokine molecules for use in cancer immunotherapy...
  16. ncbi Production and characterization of a tumor-specific monoclonal antibody ACT19 recognizing an epitope distinctive from sialosyl-Tn on the TAG72 antigen
    J Xiang
    Department of Microbiology, University of Saskatchewan, Saskatoon, Canada
    Tumori 79:58-65. 1993
    ..CONCLUSIONS: The ACT19 antibody appears to be a useful marker for colon and stomach cancers, and this additional anti-TAG72 antibody may be useful in conjunction with the B72.3 antibody in pathology and clinical application...
  17. ncbi Epigenetic transfer of metastatic activity by uptake of highly metastatic B16 melanoma cell-released exosomes
    S Hao
    Research Unit, Division of Health Research, Saskatchewan Cancer Agency, Saskatoon, Saskatchewan, Canada
    Exp Oncol 28:126-31. 2006
    ..To investigate potential role of highly metastatic BL6-10 tumor cell-released exosomes (EXO) in transfer of metastatic activity into poorly metastatic tumor cell line F1...