Linda A Parker
Affiliation: Wilfrid Laurier University
Parker L, Mechoulam R. Cannabinoid agonists and antagonists modulate lithium-induced conditioned gaping in rats. Integr Physiol Behav Sci. 2003;38:133-45 pubmed
..Finally, SR-141716 potentiated lithium-induced conditioned gaping, suggesting that the endogenous cannabinoid system plays a role in the control of nausea. ..
Parke L, Burton P, McDonald R, Kim J, Siegel S. Ibogaine interferes with motivational and somatic effects of naloxone-precipitated withdrawal from acutely administered morphine. Prog Neuropsychopharmacol Biol Psychiatry. 2002;26:293-7 pubmed
..In Experiment 1, ibogaine-treated rats displayed a weaker aversion to the withdrawal-paired chamber, and in Experiment 2, ibogaine-treated rats displayed fewer somatic withdrawal reactions than did saline treated rats. ..
Parker L, Limebeer C. Conditioned gaping in rats: a selective measure of nausea. Auton Neurosci. 2006;129:36-41 pubmed
..The conditioned gaping reaction can be used as a pre-clinical tool to evaluate the side effects of nausea that might result from newly developed pharmaceutical agents. ..
Parker L, Kwiatkowska M, Mechoulam R. Delta-9-tetrahydrocannabinol and cannabidiol, but not ondansetron, interfere with conditioned retching reactions elicited by a lithium-paired context in Suncus murinus: An animal model of anticipatory nausea and vomiting. Physiol Behav. 2006;87:66-71 pubmed
..These results support anecdotal claims that marijuana, but not ondansetron, may suppress the expression of anticipatory nausea...