Linda A Parker

Summary

Affiliation: Wilfrid Laurier University
Country: Canada

Publications

  1. ncbi request reprint Ibogaine interferes with motivational and somatic effects of naloxone-precipitated withdrawal from acutely administered morphine
    Linda A Parke
    Department of Psychology, Wilfrid Laurier University, Waterloo, Ontario, Canada
    Prog Neuropsychopharmacol Biol Psychiatry 26:293-7. 2002
  2. ncbi request reprint Cannabinoid agonists and antagonists modulate lithium-induced conditioned gaping in rats
    Linda A Parker
    Department of Psychology, Wilfrid Laurier University, Waterloo, Ontario
    Integr Physiol Behav Sci 38:133-45. 2003
  3. ncbi request reprint Taste avoidance and taste aversion: evidence for two different processes
    Linda A Parker
    Department of Psychology, Wilfrid Laurier University, Waterloo, Ontario, Canada
    Learn Behav 31:165-72. 2003
  4. ncbi request reprint Delta-9-tetrahydrocannabinol and cannabidiol, but not ondansetron, interfere with conditioned retching reactions elicited by a lithium-paired context in Suncus murinus: An animal model of anticipatory nausea and vomiting
    Linda A Parker
    Department of Psychology, Wilfrid Laurier University, Waterloo, Ontario, Canada N2L 3C5
    Physiol Behav 87:66-71. 2006
  5. ncbi request reprint The role of nausea in taste avoidance learning in rats and shrews
    Linda A Parker
    Department of Psychology, Wilfrid Laurier University, Waterloo, Ontario, Canada N2L 3C5
    Auton Neurosci 125:34-41. 2006
  6. ncbi request reprint Effects of cannabinoids on lithium-induced conditioned rejection reactions in a rat model of nausea
    Linda A Parker
    Department of Psychology, Wilfrid Laurier University, Waterloo, Ontario, Canada N2L 3C5
    Psychopharmacology (Berl) 166:156-62. 2003
  7. ncbi request reprint The aversive properties of acute morphine dependence persist 48 h after a single exposure to morphine: evaluation by taste and place conditioning
    Linda A Parker
    Department of Psychology, Wilfrid Laurier University, Waterloo, Ontario, Canada N2L 3C5
    Pharmacol Biochem Behav 72:87-92. 2002
  8. ncbi request reprint Amphetamine and morphine produce a conditioned taste and place preference in the house musk shrew (Suncus murinus)
    Linda A Parker
    Department of Psychology, Wilfrid Laurier University, Waterloo, Ontario, Canada N2L 3C5
    J Exp Psychol Anim Behav Process 28:75-82. 2002
  9. ncbi request reprint Conditioned gaping in rats: a selective measure of nausea
    Linda A Parker
    Department of Psychology, Wilfrid Laurier University, Waterloo, Ontario, Canada N2L 3C5
    Auton Neurosci 129:36-41. 2006
  10. ncbi request reprint Effect of low doses of delta9-tetrahydrocannabinol and cannabidiol on the extinction of cocaine-induced and amphetamine-induced conditioned place preference learning in rats
    Linda A Parker
    Department of Psychology, Wilfrid Laurier University, Waterloo, ON, Canada
    Psychopharmacology (Berl) 175:360-6. 2004

Collaborators

Detail Information

Publications58

  1. ncbi request reprint Ibogaine interferes with motivational and somatic effects of naloxone-precipitated withdrawal from acutely administered morphine
    Linda A Parke
    Department of Psychology, Wilfrid Laurier University, Waterloo, Ontario, Canada
    Prog Neuropsychopharmacol Biol Psychiatry 26:293-7. 2002
    ..In Experiment 1, ibogaine-treated rats displayed a weaker aversion to the withdrawal-paired chamber, and in Experiment 2, ibogaine-treated rats displayed fewer somatic withdrawal reactions than did saline treated rats...
  2. ncbi request reprint Cannabinoid agonists and antagonists modulate lithium-induced conditioned gaping in rats
    Linda A Parker
    Department of Psychology, Wilfrid Laurier University, Waterloo, Ontario
    Integr Physiol Behav Sci 38:133-45. 2003
    ..Finally, SR-141716 potentiated lithium-induced conditioned gaping, suggesting that the endogenous cannabinoid system plays a role in the control of nausea...
  3. ncbi request reprint Taste avoidance and taste aversion: evidence for two different processes
    Linda A Parker
    Department of Psychology, Wilfrid Laurier University, Waterloo, Ontario, Canada
    Learn Behav 31:165-72. 2003
    ..Taste avoidance may be motivated by conditioned fear rather than conditioned nausea, but taste aversion (as reflected by rejection reactions) may be motivated by conditioned nausea...
  4. ncbi request reprint Delta-9-tetrahydrocannabinol and cannabidiol, but not ondansetron, interfere with conditioned retching reactions elicited by a lithium-paired context in Suncus murinus: An animal model of anticipatory nausea and vomiting
    Linda A Parker
    Department of Psychology, Wilfrid Laurier University, Waterloo, Ontario, Canada N2L 3C5
    Physiol Behav 87:66-71. 2006
    ..These results support anecdotal claims that marijuana, but not ondansetron, may suppress the expression of anticipatory nausea...
  5. ncbi request reprint The role of nausea in taste avoidance learning in rats and shrews
    Linda A Parker
    Department of Psychology, Wilfrid Laurier University, Waterloo, Ontario, Canada N2L 3C5
    Auton Neurosci 125:34-41. 2006
    ..The results of a number of studies suggest that the nature of flavour-drug associations varies on the basis of the emetic capacity of the species...
  6. ncbi request reprint Effects of cannabinoids on lithium-induced conditioned rejection reactions in a rat model of nausea
    Linda A Parker
    Department of Psychology, Wilfrid Laurier University, Waterloo, Ontario, Canada N2L 3C5
    Psychopharmacology (Berl) 166:156-62. 2003
    ..5 mg/kg, i.p.), and HU-210 (0.001 mg/kg and 0.01 mg/kg, i.p.), and the CB(1) antagonist SR-141716A in modulating the establishment and the expression of lithium-induced conditioned rejection reactions in rats...
  7. ncbi request reprint The aversive properties of acute morphine dependence persist 48 h after a single exposure to morphine: evaluation by taste and place conditioning
    Linda A Parker
    Department of Psychology, Wilfrid Laurier University, Waterloo, Ontario, Canada N2L 3C5
    Pharmacol Biochem Behav 72:87-92. 2002
    ..These results suggest that a single morphine exposure produces long-lasting effects that persist at least 48 h beyond the agonist effects of the opiate...
  8. ncbi request reprint Amphetamine and morphine produce a conditioned taste and place preference in the house musk shrew (Suncus murinus)
    Linda A Parker
    Department of Psychology, Wilfrid Laurier University, Waterloo, Ontario, Canada N2L 3C5
    J Exp Psychol Anim Behav Process 28:75-82. 2002
    ..At the same dose, both drugs also produced a place preference in shrews. These results suggest that the potential of rewarding drugs to produce taste avoidance may vary on the basis of the ability of the species to vomit...
  9. ncbi request reprint Conditioned gaping in rats: a selective measure of nausea
    Linda A Parker
    Department of Psychology, Wilfrid Laurier University, Waterloo, Ontario, Canada N2L 3C5
    Auton Neurosci 129:36-41. 2006
    ..The conditioned gaping reaction can be used as a pre-clinical tool to evaluate the side effects of nausea that might result from newly developed pharmaceutical agents...
  10. ncbi request reprint Effect of low doses of delta9-tetrahydrocannabinol and cannabidiol on the extinction of cocaine-induced and amphetamine-induced conditioned place preference learning in rats
    Linda A Parker
    Department of Psychology, Wilfrid Laurier University, Waterloo, ON, Canada
    Psychopharmacology (Berl) 175:360-6. 2004
    ....
  11. doi request reprint FAAH inhibitor, URB-597, promotes extinction and CB(1) antagonist, SR141716, inhibits extinction of conditioned aversion produced by naloxone-precipitated morphine withdrawal, but not extinction of conditioned preference produced by morphine in rats
    Laurie A Manwell
    Department of Psychology, University of Guelph, Guelph, ON N1G2W1, Canada
    Pharmacol Biochem Behav 94:154-62. 2009
    ..3). These data support previous reports that the eCB system selectively facilitates extinction of aversive memories. URB-597 may prove useful in targeting extinction of aversively motivated behaviours...
  12. ncbi request reprint The effect of cannabidiol and URB597 on conditioned gaping (a model of nausea) elicited by a lithium-paired context in the rat
    Erin M Rock
    Department of Psychology, University of Guelph, Guelph, ON, Canada
    Psychopharmacology (Berl) 196:389-95. 2008
    ..In this study, the effect of manipulation of the endocannabinoid (EC) system on a rat model of nausea (conditioned gaping) was determined...
  13. ncbi request reprint A comparative analysis of the potential of cannabinoids and ondansetron to suppress cisplatin-induced emesis in the Suncus murinus (house musk shrew)
    Magdalena Kwiatkowska
    Department of Psychology, Wilfrid Laurier University, Waterloo, Ontario, N2L 3C5, Canada
    Psychopharmacology (Berl) 174:254-9. 2004
    ....
  14. ncbi request reprint Ondansetron and Delta-9-tetrahydrocannabinol interfere with the establishment of lithium-induced conditioned taste avoidance in the house musk shrew (Suncus murinus)
    Magdalena Kwiatkowska
    Department of Psychology, Wilfrid Laurier University, Waterloo, ON, Canada
    Behav Neurosci 119:974-82. 2005
    ..These results suggest that nausea is a necessary component of the unconditioned stimulus for the establishment of conditioned taste avoidance in the shrew, unlike the rat, which does not vomit when injected with a toxin...
  15. pmc Inhibition of monoacylglycerol lipase attenuates vomiting in Suncus murinus and 2-arachidonoyl glycerol attenuates nausea in rats
    Martin A Sticht
    Department of Psychology and Collaborative Neuroscience Program, University of Guelph, Guelph, ON, Canada
    Br J Pharmacol 165:2425-35. 2012
    ..To evaluate the role of 2-arachidonoyl glycerol (2AG) in the regulation of nausea and vomiting using animal models of vomiting and of nausea-like behaviour (conditioned gaping)...
  16. ncbi request reprint Effects of the FAAH inhibitor, URB597, and anandamide on lithium-induced taste reactivity responses: a measure of nausea in the rat
    Shelley K Cross-Mellor
    Department of Psychology, University of Guelph, Guelph, ON, Canada
    Psychopharmacology (Berl) 190:135-43. 2007
    ..Because of the rapid breakdown and hydrolysis of endocannabinoids, such as anandamide, the therapeutic effects may be enhanced by prolonging their duration of action...
  17. ncbi request reprint Effect of cannabinoids on lithium-induced vomiting in the Suncus murinus (house musk shrew)
    Linda A Parker
    Department of Psychology, Wilfrid Laurier University, Waterloo, Ontario, Canada N2L 3C5
    Psychopharmacology (Berl) 171:156-61. 2004
    ....
  18. doi request reprint Interaction between non-psychotropic cannabinoids in marihuana: effect of cannabigerol (CBG) on the anti-nausea or anti-emetic effects of cannabidiol (CBD) in rats and shrews
    Erin M Rock
    Department of Psychology, University of Guelph, Guelph, ON, Canada
    Psychopharmacology (Berl) 215:505-12. 2011
    ..The interaction between two non-psychotropic cannabinoids, cannabidiol (CBD) and cannabigerol (CBG), which have been reported to act as a 5-hydroxytryptamine 1A (5-HT(1A)) agonist and antagonist, respectively, was evaluated...
  19. ncbi request reprint Effect of delta9-tetrahydrocannabinol on quinine palatability and AM251 on sucrose and quinine palatability using the taste reactivity test
    Maegan M Jarrett
    Department of Psychology Wilfrid Laurier University Waterloo, Ontario, Canada N2L 3C5
    Physiol Behav 90:425-30. 2007
    ....
  20. ncbi request reprint Exposure to a context previously associated with nausea elicits conditioned gaping in rats: a model of anticipatory nausea
    Cheryl L Limebeer
    Department of Psychology, University of Western Ontario, London, ON, Canada
    Behav Brain Res 187:33-40. 2008
    ....
  21. ncbi request reprint Renewal effect: context-dependent extinction of a cocaine- and a morphine-induced conditioned floor preference
    Linda A Parker
    Department of Psychology, Wilfrid Laurier University, Waterloo, ON, N2L 3C5, Canada
    Psychopharmacology (Berl) 187:133-7. 2006
    ..Extinction of fear conditioning has been demonstrated to be context dependent. The experiments in this study evaluate whether extinction of a drug-cue association is also context dependent, using a conditioned floor preference procedure...
  22. doi request reprint Reducing endocannabinoid metabolism with the fatty acid amide hydrolase inhibitor, URB597, fails to modify reinstatement of morphine-induced conditioned floor preference and naloxone-precipitated morphine withdrawal-induced conditioned floor avoidance
    Amanda L McCallum
    Department of Psychology, University of Guelph, Guelph, Ontario, Canada
    Pharmacol Biochem Behav 96:496-500. 2010
    ..That is, although activation of the endocannabinoid (eCB) system promotes extinction of aversive learning, it may not prevent reinstatement of that aversion by re-exposure to the aversive treatment...
  23. doi request reprint Co-sensitivity to the incentive properties of palatable food and cocaine in rats; implications for co-morbid addictions
    Annemarie Levy
    Department of Psychology, University of Guelph, Ontario, Canada
    Addict Biol 18:763-73. 2013
    ..This supports the hypothesis that co-morbid food-drug addictions may result from a shared vulnerability to acquire behaviors motivated by strong incentives...
  24. doi request reprint The effects of acute and chronic steady state methadone on memory retrieval in rats
    Erin Cummins
    Department of Psychology, University of Guelph, Guelph, N1G 2W1, Ontario, Canada
    Psychopharmacology (Berl) 222:225-35. 2012
    ..Although widely prescribed to treat opioid addiction, little is known about the possible side effects of methadone on memory functions...
  25. doi request reprint Ondansetron interferes with unconditioned lying-on belly and acquisition of conditioned gaping induced by LiCl as models of nausea-induced behaviors in rats
    Katharine J Tuerke
    Department of Psychology and Collaborative Neuroscience Program, University of Guelph, Guelph, Ontario, Canada
    Physiol Behav 105:856-60. 2012
    ..The frequency of gaping and duration of LOB were highly correlated. These results provide additional support for the validity of the conditioned gaping model as a rodent model of nausea-induced behavior...
  26. ncbi request reprint Exposure to a lithium-paired context elicits gaping in rats: A model of anticipatory nausea
    Cheryl L Limebeer
    Department of Psychology, Wilfrid Laurier University, Waterloo, Ontario, Canada N2L 2C5
    Physiol Behav 88:398-403. 2006
    ....
  27. doi request reprint Effect of selective inhibition of monoacylglycerol lipase (MAGL) on acute nausea, anticipatory nausea, and vomiting in rats and Suncus murinus
    Linda A Parker
    Department of Psychology and Collaborative Neuroscience Program, University of Guelph, Guelph, ON, N1G2W1, Canada
    Psychopharmacology (Berl) 232:583-93. 2015
    ..To determine the role of the endocannabinoid, 2-arachodonyl glycerol (2-AG), in the regulation of nausea and vomiting...
  28. ncbi request reprint Vestibular lesions selectively abolish body rotation-induced, but not lithium-induced, conditioned taste aversions (oral rejection responses) in rats
    Klaus Peter Ossenkopp
    Department of Psychology, Neuroscience Program, University of Western Ontario, London, Canada
    Behav Neurosci 117:105-12. 2003
    ..The finding that normal vestibular function is necessary in obtaining rotation-induced conditioned taste aversions supports the face and construct validity of a rat model of motion sickness...
  29. doi request reprint Differential effects of neurotoxin-induced lesions of the basolateral amygdala and central nucleus of the amygdala on lithium-induced conditioned disgust reactions and conditioned taste avoidance
    Shadna A Rana
    Department of Psychology, Wilfrid Laurier University, Waterloo, ON, Canada
    Behav Brain Res 189:284-97. 2008
    ..The results are discussed in light of current models of the role of the amygdala in aversive learning...
  30. pmc Evaluation of the potential of the phytocannabinoids, cannabidivarin (CBDV) and Δ(9) -tetrahydrocannabivarin (THCV), to produce CB1 receptor inverse agonism symptoms of nausea in rats
    Erin M Rock
    Department of Psychology and Neuroscience Graduate Program, University of Guelph, Guelph, ON, Canada
    Br J Pharmacol 170:671-8. 2013
    ..Here, we evaluated two phytocannabinoids, cannabidivarin (CBDV) and Δ(9) -tetrahydrocannabivarin (THCV), for their ability to produce these behavioural effect characteristics of CB1 receptor inverse agonism in rats...
  31. ncbi request reprint The 5-HT1A agonist 8-OH-DPAT dose-dependently interferes with the establishment and the expression of lithium-induced conditioned rejection reactions in rats
    Cheryl L Limebeer
    Department of Psychology, University of Waterloo, Waterloo, Ontario, Canada
    Psychopharmacology (Berl) 166:120-6. 2003
    ..OBJECTIVES. To determine the effect of reduced serotonin availability on conditioned rejection reactions, a rat model of nausea...
  32. doi request reprint Effect of 5-HT3 antagonists and a 5-HT(1A) agonist on fluoxetine-induced conditioned gaping reactions in rats
    Cheryl L Limebeer
    Department of Psychology, University of Guelph, Guelph, Ontario, Canada, N1H 2W1
    Psychopharmacology (Berl) 203:763-70. 2009
    ..The effect of manipulation of the serotonin (5-HT) system on conditioned gaping (presumably reflective of nausea in rats) was evaluated...
  33. ncbi request reprint Cannabidiol, a non-psychoactive component of cannabis and its synthetic dimethylheptyl homolog suppress nausea in an experimental model with rats
    Linda A Parker
    Department of Psychology, Wilfrid Laurier University, Waterloo, Ontario N2L 3C5, Canada
    Neuroreport 13:567-70. 2002
    ..These results suggest that cannabinoids without psychoactive side-effects may have therapeutic value in the treatment of chemotherapy-induced nausea...
  34. ncbi request reprint Effect of conditioning method and testing method on strength of lithium-induced taste aversion learning
    Cheryl L Limebeer
    Department of Psychology, Wilfrid Laurier University, Waterloo, ON, Canada
    Behav Neurosci 120:963-9. 2006
    ..These results may shed light on recent reports that different neural mechanisms are involved in conditioning by active consumption and passive infusion...
  35. ncbi request reprint 5,7-dihydroxytryptamine lesions of the dorsal and median raphe nuclei interfere with lithium-induced conditioned gaping, but not conditioned taste avoidance, in rats
    Cheryl L Limebeer
    Department of Psychology, Wilfrid Laurier University, Waterloo, Ontario, Canada
    Behav Neurosci 118:1391-9. 2004
    ..These results parallel previous pharmacological findings indicating that reduction of serotonin activity interferes with conditioned gaping, but not conditioned taste avoidance...
  36. pmc Double Dissociation of Monoacylglycerol Lipase Inhibition and CB1 Antagonism in the Central Amygdala, Basolateral Amygdala, and the Interoceptive Insular Cortex on the Affective Properties of Acute Naloxone-Precipitated Morphine Withdrawal in Rats
    Kiri L Wills
    Collaborative Neuroscience Program, Department of Psychology, University of Guelph, Guelph, ON, Canada
    Neuropsychopharmacology 41:1865-73. 2016
    ..These findings reveal the respective sites of action of systemically administered MJN110 and AM251 in regulating the aversive effects of MWD. ..
  37. ncbi request reprint Effect of Delta9-tetrahydrocannabinol on sucrose palatability as measured by the taste reactivity test
    Maegan M Jarrett
    Department of Psychology, Wilfrid Laurier University, Waterloo, Ontario, Canada, N2L 3C5
    Physiol Behav 86:475-9. 2005
    ....
  38. doi request reprint Conditioned nausea in rats: assessment by conditioned disgust reactions, rather than conditioned taste avoidance
    Linda A Parker
    Department of Psychology, University of Guelph, uelph, ON
    Can J Exp Psychol 62:198-209. 2008
    ..Taste avoidance may be motivated by conditioned fear rather than conditioned nausea, but conditioned disgust is motivated by conditioned nausea...
  39. doi request reprint Potential of the rat model of conditioned gaping to detect nausea produced by rolipram, a phosphodiesterase-4 (PDE4) inhibitor
    Erin M Rock
    Department of Psychology, University of Guelph, Guelph, Ontario, Canada N1G 2W1
    Pharmacol Biochem Behav 91:537-41. 2009
    ....
  40. ncbi request reprint Effect of sodium deprivation on morphine-and lithium-induced conditioned salt avoidance and taste reactivity
    Robert E Sorge
    Department of Psychology, Wilfrid Laurier University, Waterloo, Ontario, N2L 3C5, Canada
    Psychopharmacology (Berl) 160:84-91. 2002
    ..Therefore, morphine should more effectively suppress intake of salt solution in rats that are conditioned in a sodium-deprived state than in rats that are conditioned in a sodium-replete state...
  41. doi request reprint Antidepressant-like effects of paroxetine are produced by lower doses than those which produce nausea
    Katharine J Tuerke
    University of Guelph, Ontario, Canada
    Pharmacol Biochem Behav 93:190-5. 2009
    ..The TR test may be beneficial for assessing the side effect of nausea in preclinical tests of new compounds...
  42. ncbi request reprint Artificial rearing alters the response of rats to natural and drug-mediated rewards
    Anna M Lomanowska
    Department of Health Studies and Gerontology, University of Waterloo, Waterloo, Ont N2L 3G1, Canada
    Dev Psychobiol 48:301-14. 2006
    ..These findings support the potential of the AR model to contribute to understanding the role of early experience in the development of behavioral motivation...
  43. doi request reprint Interference with acute nausea and anticipatory nausea in rats by fatty acid amide hydrolase (FAAH) inhibition through a PPARα and CB1 receptor mechanism, respectively: a double dissociation
    Erin M Rock
    Department of Psychology and Collaborative Neuroscience Program, University of Guelph, Guelph, ON, N1G 2W1, Canada
    Psychopharmacology (Berl) 232:3841-8. 2015
    ..Here, we determine the mechanism of action of FAAH inhibition on acute and anticipatory nausea (AN)...
  44. pmc Increased liking for a solution is not necessary for the attenuation of neophobia in rats
    Karly N Neath
    Department of Psychology, University of Guelph, Guelph, Ont, N1G 2W1, Canada
    Behav Neurosci 124:398-404. 2010
    ..These results suggest that the attenuation of neophobia is evidenced as an increase in the tendency to approach a bottle containing the flavored solution (wanting), but not as an enhanced liking of that solution...
  45. doi request reprint Cannabinoid 2 (CB2) receptor agonism reduces lithium chloride-induced vomiting in Suncus murinus and nausea-induced conditioned gaping in rats
    Erin M Rock
    Department of Psychology and Collaborative Neuroscience Program, University of Guelph, Guelph, ON, Canada
    Eur J Pharmacol 786:94-9. 2016
    ....
  46. doi request reprint A comparison of novel, selective fatty acid amide hydrolase (FAAH), monoacyglycerol lipase (MAGL) or dual FAAH/MAGL inhibitors to suppress acute and anticipatory nausea in rat models
    Linda A Parker
    Department of Psychology and Collaborative Neuroscience Program, University of Guelph, Guelph, ON, N1G2W1, Canada
    Psychopharmacology (Berl) 233:2265-75. 2016
    ....
  47. doi request reprint Endocannabinoid Mechanisms Influencing Nausea
    Martin A Sticht
    Department of Psychology, Collaborative Neuroscience Graduate Program, University of Guelph, Guelph, Ontario, Canada Department of Physiology and Pharmacology, Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada
    Int Rev Neurobiol 125:127-62. 2015
    ..In this review, we describe recent evidence suggesting that cannabinoids and manipulations that enhance the functioning of the natural endocannabinoid system are promising treatments for both acute nausea and AN. ..
  48. doi request reprint CB1 receptor antagonism in the granular insular cortex or somatosensory area facilitates consolidation of object recognition memory
    Lesley D O'Brien
    Department of Psychology and Collaborative Neuroscience Program University of Guelph, Guelph, ON, Canada
    Neurosci Lett 578:192-6. 2014
    ....
  49. doi request reprint A comparison of cannabidiolic acid with other treatments for anticipatory nausea using a rat model of contextually elicited conditioned gaping
    Erin M Rock
    Department of Psychology and Collaborative Neuroscience Program, University of Guelph, 50 Stone Rd E, Guelph, ON, N1G 2W1, Canada
    Psychopharmacology (Berl) 231:3207-15. 2014
    ..The effectiveness of cannabidiolic acid (CBDA) was compared with other potential treatments for anticipatory nausea (AN), using a rat model of contextually elicited conditioned gaping reactions...
  50. doi request reprint Double dissociation between regulation of conditioned disgust and taste avoidance by serotonin availability at the 5-HT(3) receptor in the posterior and anterior insular cortex
    Katharine J Tuerke
    Department of Psychology and Collaborative Neuroscience Program, University of Guelph, Guelph, Ontario N1G 2W1, Canada
    J Neurosci 32:13709-17. 2012
    ....
  51. ncbi request reprint Effect of prior exposure to a lithium- and an amphetamine-paired flavor on the acoustic startle response in rats
    Shadna A Rana
    Department of PsychologyWilfrid Laurier University, Waterloo, ON, Canada
    J Exp Psychol Anim Behav Process 33:172-84. 2007
    ..The findings shed light on a mechanism by which rewarding drugs produce conditioned taste avoidance in rats...
  52. doi request reprint Effect of combined oral doses of Δ(9)-tetrahydrocannabinol (THC) and cannabidiolic acid (CBDA) on acute and anticipatory nausea in rat models
    Erin M Rock
    Department of Psychology and Collaborative Neuroscience Program, University of Guelph, Guelph, ON, N1G 2W1, Canada
    Psychopharmacology (Berl) 233:3353-60. 2016
    ..The purpose of this study was to evaluate the potential of oral combined cannabis constituents to reduce nausea...
  53. doi request reprint Effect of combined doses of Δ(9)-tetrahydrocannabinol (THC) and cannabidiolic acid (CBDA) on acute and anticipatory nausea using rat (Sprague- Dawley) models of conditioned gaping
    Erin M Rock
    Department of Psychology and Collaborative Neuroscience Program, University of Guelph, Guelph, ON, N1G 2W1, Canada
    Psychopharmacology (Berl) 232:4445-54. 2015
    ..9)-Tetrahydrocannabinol (THC) and cannabidiolic acid (CBDA) found in cannabis both reduce the distressing symptom of nausea, but their combined effects are not understood...
  54. doi request reprint Anticipatory nausea in animal models: a review of potential novel therapeutic treatments
    Erin M Rock
    Department of Psychology, University of Guelph, Guelph, ON, N1G 2W1, Canada
    Exp Brain Res 232:2511-34. 2014
    ..Accumulating evidence using animal models demonstrates that cannabinoid compounds effectively reduce AN, without producing sedation. These results highlight the need for human clinical trials evaluating the efficacy of these compounds...
  55. doi request reprint Attenuation of anticipatory nausea in a rat model of contextually elicited conditioned gaping by enhancement of the endocannabinoid system
    Cheryl L Limebeer
    Department of Psychology and Neuroscience Graduate Program, University of Guelph, Guelph, ON, N1H 2W1, Canada
    Psychopharmacology (Berl) 231:603-12. 2014
    ..Enhancement of the endocannabinoid (EC) system may reduce anticipatory nausea (AN)...
  56. pmc Cannabinoids As Potential Treatment for Chemotherapy-Induced Nausea and Vomiting
    Erin M Rock
    Department of Psychology and Collaborative Neuroscience Graduate Program, University of Guelph Guelph, ON, Canada
    Front Pharmacol 7:221. 2016
    ..Here, we review studies assessing the therapeutic potential of cannabinoids and manipulations of the endocannabinoid system in human patients and pre-clinical animal models of nausea and vomiting. ..
  57. doi request reprint Second-order conditioning of LiCl-induced gaping with flavor and contextual cues
    Martin A Sticht
    Department Psychology, University of Guelph, Guelph, ON, N1G 2W1, Canada
    Learn Behav 43:95-100. 2015
    ..These results demonstrate that an excitatory contextual CS+ has the potential to confer second-order conditioning to a novel flavor in the absence of any direct pairing with LiCl...
  58. pmc CB1 antagonism: interference with affective properties of acute naloxone-precipitated morphine withdrawal in rats
    Kiri L Wills
    Department of Psychology and Collaborative Neuroscience Program, University of Guelph, Guelph, ON, N1G 2W1, Canada
    Psychopharmacology (Berl) 231:4291-300. 2014
    ..The potential of activation and blockade of the endocannabinoid system to prevent the aversive-affective state of naloxone-precipitated morphine withdrawal (MWD) was investigated in a one-trial conditioned place aversion (CPA) paradigm...