Richard P Whitlock

Summary

Country: Canada

Publications

  1. doi request reprint Genotype-guided versus standard vitamin K antagonist dosing algorithms in patients initiating anticoagulation. A systematic review and meta-analysis
    Emilie P Belley-Côté
    Richard Whitlock, David Braley Cardiac, Vascular and Stroke Research Institute, Room 1C1 5B, 237 Barton St E, Hamilton, Ontario L8L 2X2, Canada, Tel 1 905 527 4322 ext 44091, Fax 1 905 577 8017, E mail
    Thromb Haemost 114:768-77. 2015
  2. doi request reprint Methylprednisolone in patients undergoing cardiopulmonary bypass (SIRS): a randomised, double-blind, placebo-controlled trial
    Richard P Whitlock
    Population Health Research Institute, Hamilton Health Sciences and McMaster University, Hamilton, ON, Canada Department of Surgery, McMaster University, Hamilton, ON, Canada Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON, Canada Electronic address
    Lancet 386:1243-53. 2015
  3. doi request reprint Efficacy and safety of early parenteral anticoagulation as a bridge to warfarin after mechanical valve replacement
    J G Mathew
    Dr Richard Whitlock, MD, PhD, David Braley Cardiac, Vascular and Stroke Research Institute, 237 Barton Street East, Room 1C1 114, Hamilton, Ontario, Canada, L8L 2X2, Tel 1 905 521 2100 40306, E mail
    Thromb Haemost 112:1120-8. 2014
  4. pmc SodiUm SeleniTe Adminstration IN Cardiac Surgery (SUSTAIN CSX-trial): study design of an international multicenter randomized double-blinded controlled trial of high dose sodium-selenite administration in high-risk cardiac surgical patients
    Christian Stoppe
    Department of Anesthesiology, University Hospital of the RWTH Aachen, Pauwelsstrase 30, 52074 Aachen, Germany
    Trials 15:339. 2014
  5. pmc Association between angiotensin converting enzyme inhibitor or angiotensin receptor blocker use prior to major elective surgery and the risk of acute dialysis
    Mitesh Shah
    Division of Nephrology, Department of Medicine, Western University, London, Canada
    BMC Nephrol 15:53. 2014
  6. doi request reprint Rationale and design of the steroids in cardiac surgery trial
    Richard Whitlock
    Population Health Research Institute, McMaster University Hamilton Health Sciences, Hamilton, Canada Electronic address
    Am Heart J 167:660-5. 2014
  7. doi request reprint Left Atrial Appendage Occlusion Study II (LAAOS II)
    Richard P Whitlock
    Population Health Research Institute, Hamilton Health Sciences McMaster University, Hamilton, Ontario, Canada Electronic address
    Can J Cardiol 29:1443-7. 2013
  8. doi request reprint Processed residual pump blood in cardiac surgery: the Processed Residual Blood in Cardiac surgery trial
    Richard Whitlock
    McMaster University, Hamilton, Ontario, Canada
    Transfusion 53:1487-92. 2013
  9. doi request reprint Nonpharmacologic approaches to stroke prevention in atrial fibrillation
    Richard P Whitlock
    Population Health Research Institute, McMaster University, Hamilton, Ontario, Canada
    Can J Cardiol 29:S79-86. 2013
  10. pmc Antithrombotic and thrombolytic therapy for valvular disease: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines
    Richard P Whitlock
    Population Health Research Institute, McMaster University, David Braley Cardiac, Vascular, and Stroke Research Institute, 237 Barton St East, Room C1 114, Hamilton, ON, L8L 2X2, Canada
    Chest 141:e576S-600S. 2012

Collaborators

Detail Information

Publications26

  1. doi request reprint Genotype-guided versus standard vitamin K antagonist dosing algorithms in patients initiating anticoagulation. A systematic review and meta-analysis
    Emilie P Belley-Côté
    Richard Whitlock, David Braley Cardiac, Vascular and Stroke Research Institute, Room 1C1 5B, 237 Barton St E, Hamilton, Ontario L8L 2X2, Canada, Tel 1 905 527 4322 ext 44091, Fax 1 905 577 8017, E mail
    Thromb Haemost 114:768-77. 2015
    ..An improvement in TTR was observed in comparison with fixed VKA dosing algorithms, but not with clinical algorithms...
  2. doi request reprint Methylprednisolone in patients undergoing cardiopulmonary bypass (SIRS): a randomised, double-blind, placebo-controlled trial
    Richard P Whitlock
    Population Health Research Institute, Hamilton Health Sciences and McMaster University, Hamilton, ON, Canada Department of Surgery, McMaster University, Hamilton, ON, Canada Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON, Canada Electronic address
    Lancet 386:1243-53. 2015
    ..We aimed to assess the effects of steroids in patients at high risk of morbidity and mortality undergoing cardiopulmonary bypass...
  3. doi request reprint Efficacy and safety of early parenteral anticoagulation as a bridge to warfarin after mechanical valve replacement
    J G Mathew
    Dr Richard Whitlock, MD, PhD, David Braley Cardiac, Vascular and Stroke Research Institute, 237 Barton Street East, Room 1C1 114, Hamilton, Ontario, Canada, L8L 2X2, Tel 1 905 521 2100 40306, E mail
    Thromb Haemost 112:1120-8. 2014
    ..5 to 3-fold increased risk of major bleeding compared with prophylactic dose bridging. ..
  4. pmc SodiUm SeleniTe Adminstration IN Cardiac Surgery (SUSTAIN CSX-trial): study design of an international multicenter randomized double-blinded controlled trial of high dose sodium-selenite administration in high-risk cardiac surgical patients
    Christian Stoppe
    Department of Anesthesiology, University Hospital of the RWTH Aachen, Pauwelsstrase 30, 52074 Aachen, Germany
    Trials 15:339. 2014
    ..Thus, a large-scale study is needed to investigate the effect of perioperative selenium supplementation on the occurrence of postoperative organ dysfunction...
  5. pmc Association between angiotensin converting enzyme inhibitor or angiotensin receptor blocker use prior to major elective surgery and the risk of acute dialysis
    Mitesh Shah
    Division of Nephrology, Department of Medicine, Western University, London, Canada
    BMC Nephrol 15:53. 2014
    ..Some studies but not others suggest angiotensin converting enzyme inhibitor (ACEi) or angiotensin receptor blocker (ARB) use prior to major surgery associates with a higher risk of postoperative acute kidney injury (AKI) and death...
  6. doi request reprint Rationale and design of the steroids in cardiac surgery trial
    Richard Whitlock
    Population Health Research Institute, McMaster University Hamilton Health Sciences, Hamilton, Canada Electronic address
    Am Heart J 167:660-5. 2014
    ..Steroids may improve outcomes in high-risk patients undergoing cardiac surgery with the use of cardiopulmonary bypass (CBP). There is a need\ for a large randomized controlled trial to clarify the effect of steroids in such patients...
  7. doi request reprint Left Atrial Appendage Occlusion Study II (LAAOS II)
    Richard P Whitlock
    Population Health Research Institute, Hamilton Health Sciences McMaster University, Hamilton, Ontario, Canada Electronic address
    Can J Cardiol 29:1443-7. 2013
    ..The Left Atrial Appendage Occlusion Study II (LAAOS II) explored the feasibility of a definitive trial of LAA occlusion for stroke prevention in AF...
  8. doi request reprint Processed residual pump blood in cardiac surgery: the Processed Residual Blood in Cardiac surgery trial
    Richard Whitlock
    McMaster University, Hamilton, Ontario, Canada
    Transfusion 53:1487-92. 2013
    ..We sought to establish if processing residual CPB volume with ultrafiltration reduces homologous blood transfusion and bleeding...
  9. doi request reprint Nonpharmacologic approaches to stroke prevention in atrial fibrillation
    Richard P Whitlock
    Population Health Research Institute, McMaster University, Hamilton, Ontario, Canada
    Can J Cardiol 29:S79-86. 2013
    ..Future trials will need to address novel OAC therapy when comparing them with LAA exclusion, and large randomized trials will be required to ascertain indications for nonpharmacologic therapy in current practice. ..
  10. pmc Antithrombotic and thrombolytic therapy for valvular disease: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines
    Richard P Whitlock
    Population Health Research Institute, McMaster University, David Braley Cardiac, Vascular, and Stroke Research Institute, 237 Barton St East, Room C1 114, Hamilton, ON, L8L 2X2, Canada
    Chest 141:e576S-600S. 2012
    ..Antithrombotic therapy in valvular disease is important to mitigate thromboembolism, but the hemorrhagic risk imposed must be considered...
  11. doi request reprint Effects of off-pump and on-pump coronary-artery bypass grafting at 1 year
    Andre Lamy
    The Population Health Research Institute, Hamilton Health Sciences, McMaster University, Hamilton, ON, Canada
    N Engl J Med 368:1179-88. 2013
    ..We now report results on quality of life and cognitive function and on clinical outcomes at 1 year...
  12. doi request reprint Subtle differences in commercial heparins can have serious consequences for cardiopulmonary bypass patients: A randomized controlled trial
    Kyle A Arsenault
    McMaster University Michael G DeGroote School of Medicine, Hamilton, Ontario, Canada
    J Thorac Cardiovasc Surg 144:944-950.e3. 2012
    ..To compare the potency, reversibility, and perioperative bleeding risk of Hepalean with those of PPC heparin...
  13. doi request reprint Randomized trial of aspirin and clopidogrel versus aspirin alone for the prevention of coronary artery bypass graft occlusion: the Preoperative Aspirin and Postoperative Antiplatelets in Coronary Artery Bypass Grafting study
    Jack C J Sun
    Division of Cardiac Surgery, McMaster University, Hamilton, Canada
    Am Heart J 160:1178-84. 2010
    ..We performed a pilot study measuring safety and efficacy outcomes of aspirin and clopidogrel therapy after CABG...
  14. ncbi request reprint Warfarin cessation before cardiopulmonary bypass: lessons learned from a randomized controlled trial of oral vitamin K
    Richard P Whitlock
    Division of Cardiac Surgery, HHSC, McMaster University, Hamilton, Ontario, Canada
    Ann Thorac Surg 84:103-8. 2007
    ..Administration of preoperative oral vitamin K was investigated in a randomized, placebo-controlled trial. A post hoc analysis examined residual anti-Xa activity of enoxaparin bridging...
  15. doi request reprint Clinical benefit of steroid use in patients undergoing cardiopulmonary bypass: a meta-analysis of randomized trials
    Richard P Whitlock
    Division of Cardiac Surgery, McMaster University, Hamilton, Ontario, Canada
    Eur Heart J 29:2592-600. 2008
    ..These data do not raise major safety concerns, however, a sufficiently powered trial is warranted to confirm or refute these findings...
  16. doi request reprint Direct thrombin inhibitors in cardiovascular disease
    Kyle A Arsenault
    Michael G DeGroote School of Medicine, McMaster University, 1280 Main Street West, Hamilton, ON L8S 4L8, Canada
    Nat Rev Cardiol 9:402-14. 2012
    ....
  17. doi request reprint Kidney function after off-pump or on-pump coronary artery bypass graft surgery: a randomized clinical trial
    Amit X Garg
    Division of Nephrology, Department of Medicine, Western University, London, Ontario, Canada2Department of Epidemiology and Biostatistics, Western University, London, Ontario, Canada3Department of Clinical Epidemiology and Biostatistics, McMaster Universit
    JAMA 311:2191-8. 2014
    ..Such acute kidney injury is associated with lower long-term kidney function. However, it has not been demonstrated that an intervention that reduces the risk of such acute kidney injury better preserves long-term kidney function...
  18. doi request reprint Off-pump or on-pump coronary-artery bypass grafting at 30 days
    Andre Lamy
    Population Health Research Institute, Hamilton Health Sciences, McMaster University, Hamilton, ON, Canada
    N Engl J Med 366:1489-97. 2012
    ..The relative benefits and risks of performing coronary-artery bypass grafting (CABG) with a beating-heart technique (off-pump CABG), as compared with cardiopulmonary bypass (on-pump CABG), are not clearly established...
  19. ncbi request reprint Pro: Steroids should be used for cardiopulmonary bypass
    Richard P Whitlock
    Division of Cardiac Surgery, McMaster University, Hamilton Health Sciences Corporation, Hamilton, Ontario, Canada
    J Cardiothorac Vasc Anesth 19:250-4. 2005
  20. doi request reprint Methylprednisolone Does Not Reduce Persistent Pain after Cardiac Surgery
    Alparslan Turan
    From the Department of Outcomes Research, Anesthesiology Institute, Cleveland Clinic, Cleveland, Ohio A T, D I S, J P Y, V N, S A Departments of Clinical Epidemiology and Biostatistics E P B C, P J D, A L, R P W and Medicine P J D, S Y, McMaster University, Hamilton, Ontario, Canada Population Health Research Institute, Hamilton Health Sciences, McMaster University, Hamilton, Ontario, Canada J V, P J D, S Y, A L, R P W Department of Surgery, Population Health Research Institute, Hamilton Health Sciences, McMaster University, Hamilton, Ontario, Canada R v O, G C, A L, R P W Department of Anesthesiology, West China Hospital, Sichuan University, Chengdu, China H Y Division of Cardiac Surgery
    Anesthesiology 123:1404-10. 2015
    ..Therefore, the authors tested the primary hypothesis that patients randomized to methylprednisolone have less persistent incisional pain than those given placebo...
  21. doi request reprint Interventions for preventing post-operative atrial fibrillation in patients undergoing heart surgery
    Kyle A Arsenault
    Department of Surgery, McMaster University, Hamilton, Canada
    Cochrane Database Syst Rev 1:CD003611. 2013
    ..We conducted an update to a 2004 Cochrane systematic review and meta-analysis of the literature to gain a better understanding of the effectiveness of these interventions...
  22. doi request reprint Preoperative intra-aortic balloon pump in patients undergoing coronary bypass surgery: a systematic review and meta-analysis
    Adel M Dyub
    Division of Cardiac Surgery, McMaster University, Hamilton, Ontario, Canada
    J Card Surg 23:79-86. 2008
    ..The primary outcome was hospital mortality and secondary outcomes were IABP-related complications (bleeding, leg ischemia, aortic dissection)...
  23. ncbi request reprint Warfarin-associated multiple digital necrosis complicating heparin-induced thrombocytopenia and Raynaud's phenomenon after aortic valve replacement for adenocarcinoma-associated thrombotic endocarditis
    Theodore E Warkentin
    Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada
    Am J Hematol 75:56-62. 2004
    ....
  24. doi request reprint The use of transcutaneous oximetry to predict complications of chronic wound healing: a systematic review and meta-analysis
    Kyle A Arsenault
    Department of Surgery, McMaster University, Hamilton, Ontario, Canada
    Wound Repair Regen 19:657-63. 2011
    ..These results suggest that P(tc) O(2) measurements have independent prognostic value in the assessment of chronic wounds, but further research is required to confirm these findings and define an optimal threshold value...
  25. doi request reprint Dabigatran is Less Effective Than Warfarin at Attenuating Mechanical Heart Valve-Induced Thrombin Generation
    Iqbal H Jaffer
    Thrombosis and Atherosclerosis Research Institute, McMaster University, Hamilton, Ontario, Canada I H J, A R S, J C F, J I W Department of Surgery, McMaster University, Hamilton, Ontario, Canada I H J, R P W Department of Medical Sciences, McMaster University, Hamilton, Ontario, Canada I H J, J I W
    J Am Heart Assoc 4:e002322. 2015
    ..To determine why dabigatran was less effective than warfarin, we compared their effects on thrombin generation induced by MHV...
  26. pmc Para-aortic arch abscess secondary to Staphylococcus aureus pneumonia
    Karen K Koo
    Department of Critical Care Medicine, McMaster University, Hamilton, Canada
    Can J Cardiol 25:233-6. 2009
    ..The patient was successfully managed nonsurgically with computed tomography-guided drainage and intravenous antibiotics...