Raymund J Wellinger

Summary

Country: Canada

Publications

  1. doi request reprint When the caps fall off: responses to telomere uncapping in yeast
    Raymund J Wellinger
    Department of Microbiology and Infectious Diseases, Faculty of Medicine, Universite de Sherbrooke, Sherbrooke, Quebec, Canada
    FEBS Lett 584:3734-40. 2010
  2. doi request reprint In the End, What's the Problem?
    Raymund J Wellinger
    Department of Microbiology and Infectious Diseases, Faculty of Medicine and Health Sciences, Universite de Sherbrooke, Sherbrooke, QC J1E 4K8, Canada Electronic address
    Mol Cell 53:855-6. 2014
  3. doi request reprint The CST complex and telomere maintenance: the exception becomes the rule
    Raymund J Wellinger
    Department of Microbiology and Infectious Diseases, Universite de Sherbrooke, Sherbrooke, QC J1H 5N4, Canada
    Mol Cell 36:168-9. 2009
  4. pmc Cell cycle-dependent transcription factors control the expression of yeast telomerase RNA
    Isabelle Dionne
    RNA Group, Department of Microbiology and Infectiology, Faculty of Medicine and Health Sciences, Universite de Sherbrooke, Sherbrooke, Québec J1E 4K8, Canada
    RNA 19:992-1002. 2013
  5. pmc Telomere capping in non-dividing yeast cells requires Yku and Rap1
    Momchil D Vodenicharov
    Department of Microbiology and Infectious Diseases, Faculty of Medicine, Universite de Sherbrooke, Sherbrooke, Quebec, Canada
    EMBO J 29:3007-19. 2010
  6. ncbi request reprint RNase III-dependent regulation of yeast telomerase
    Stephanie Larose
    RNA Group, Departement de Microbiologie et d Infectiologie, Facultéde Médecine, Universite de Sherbrooke, Sherbrooke, Quebec J1H 5N4, Canada
    J Biol Chem 282:4373-81. 2007
  7. ncbi request reprint Telomerase- and capping-independent yeast survivors with alternate telomere states
    Michel Larrivée
    Department of Microbiology and Infectious Diseases, Faculty of Medicine, Universite de Sherbrooke, Sherbrooke, Quebec, J1H 5N4, Canada
    Nat Cell Biol 8:741-7. 2006
  8. doi request reprint Differential participation of homologous recombination and nucleotide excision repair in yeast survival to ultraviolet light radiation
    Martin Toussaint
    Departement de Microbiologie et d Infectiologie, Faculte de Medecine, Universite de Sherbrooke, Sherbrooke, QC J1H 5N4, Canada
    Mutat Res 698:52-9. 2010
  9. doi request reprint Introns within ribosomal protein genes regulate the production and function of yeast ribosomes
    Julie Parenteau
    Laboratoire de génomique fonctionnelle de l Université de Sherbrooke, Departement de Microbiologie et d Infectiologie, Faculte de Medecine et des Sciences de la Sante, Universite de Sherbrooke, Quebec, Canada
    Cell 147:320-31. 2011
  10. pmc A new telomerase RNA element that is critical for telomere elongation
    Nancy Laterreur
    Department of Microbiology and Infectious Diseases and Department of Biology, RNA Group, Universite de Sherbrooke, 3201, Rue Jean Mignault, Sherbrooke J1E 4K8, Canada
    Nucleic Acids Res 41:7713-24. 2013

Collaborators

  • Sherif Abou Elela
  • Benoit Chabot
  • Mathieu Durand
  • Antonio Conconi
  • Daniel Gendron
  • Francois Bachand
  • Franck Gallardo
  • Julian P Venables
  • Eric Gilson
  • Jean Pierre Perreault
  • Chantal Autexier
  • Jean François Noël
  • Momchil D Vodenicharov
  • Catherine Lebel
  • Martin Toussaint
  • Nancy Laterreur
  • Stephanie Larose
  • Michel Larrivée
  • Amadou Bah
  • Alain T Dandjinou
  • Julie Parenteau
  • Sherif Abou Elela
  • Isabelle Dionne
  • Jean Francois Lucier
  • Mikhail Chakhparonian
  • Julien Gervais-Bird
  • Julie Pelloux
  • Panagiotis Prinos
  • Frederic Leduc
  • Geneviève Morin
  • Jules Gagnon
  • David Faucher
  • Caroline Patry
  • Serge Gravel
  • Sébastien H Eschbach
  • Daniel A Lafontaine
  • Maxime Tremblay
  • Marianne Boivin
  • Roscoe Klinck
  • Elvy Lapointe
  • Jean Philippe Brosseau
  • Hanad Nwilati
  • Mélina Arguin
  • Geneviève Bikond Nkoma
  • Marie Chantal Grégoire
  • Daniel Garneau
  • Guylain Boissonneault
  • Karine Tremblay
  • Sonia Couture
  • Philippe Thibault
  • Chu Shin Koh
  • Valerie Guerin
  • Bojana Cecez
  • Steeve Veronneau
  • David Brunelle
  • Andrée Anne Lacombe
  • Ghada Ghazal
  • Genevieve Levasseur
  • Nancy Lvesque
  • Nancy Lévesque
  • Bruno Lemieux
  • Eveline Clair

Detail Information

Publications37

  1. doi request reprint When the caps fall off: responses to telomere uncapping in yeast
    Raymund J Wellinger
    Department of Microbiology and Infectious Diseases, Faculty of Medicine, Universite de Sherbrooke, Sherbrooke, Quebec, Canada
    FEBS Lett 584:3734-40. 2010
    ..I will provide an outline of cellular responses to uncapping in budding yeast and briefly discuss the reverse, namely avoidance mechanisms that prevent telomere formation at inappropriate places...
  2. doi request reprint In the End, What's the Problem?
    Raymund J Wellinger
    Department of Microbiology and Infectious Diseases, Faculty of Medicine and Health Sciences, Universite de Sherbrooke, Sherbrooke, QC J1E 4K8, Canada Electronic address
    Mol Cell 53:855-6. 2014
    ..show that the actual mechanistic details of the chromosomal end-replication problem, the principle linking telomere biology with human cellular senescence and cancer, match previous predictions almost to the nucleotide. ..
  3. doi request reprint The CST complex and telomere maintenance: the exception becomes the rule
    Raymund J Wellinger
    Department of Microbiology and Infectious Diseases, Universite de Sherbrooke, Sherbrooke, QC J1H 5N4, Canada
    Mol Cell 36:168-9. 2009
    ..In this issue of Molecular Cell, Miyake et al. (2009) and Surovtseva et al. (2009) provide evidence that these complexes coexist and function at telomeres in many species...
  4. pmc Cell cycle-dependent transcription factors control the expression of yeast telomerase RNA
    Isabelle Dionne
    RNA Group, Department of Microbiology and Infectiology, Faculty of Medicine and Health Sciences, Universite de Sherbrooke, Sherbrooke, Québec J1E 4K8, Canada
    RNA 19:992-1002. 2013
    ..These results indicate that the budding yeast TLC1 RNA is transcribed in a cell cycle-dependent fashion late in G1 and may be part of the S phase-regulated group of genes involved in DNA replication...
  5. pmc Telomere capping in non-dividing yeast cells requires Yku and Rap1
    Momchil D Vodenicharov
    Department of Microbiology and Infectious Diseases, Faculty of Medicine, Universite de Sherbrooke, Sherbrooke, Quebec, Canada
    EMBO J 29:3007-19. 2010
    ..Together, our results show a high flexibility of the telomeric cap and suggest that distinct configurations may provide for efficient capping in dividing versus non-dividing cells...
  6. ncbi request reprint RNase III-dependent regulation of yeast telomerase
    Stephanie Larose
    RNA Group, Departement de Microbiologie et d Infectiologie, Facultéde Médecine, Universite de Sherbrooke, Sherbrooke, Quebec J1H 5N4, Canada
    J Biol Chem 282:4373-81. 2007
    ..These results reveal a new mechanism that influences telomeres length by controlling the expression of the telomerase subunits...
  7. ncbi request reprint Telomerase- and capping-independent yeast survivors with alternate telomere states
    Michel Larrivée
    Department of Microbiology and Infectious Diseases, Faculty of Medicine, Universite de Sherbrooke, Sherbrooke, Quebec, J1H 5N4, Canada
    Nat Cell Biol 8:741-7. 2006
    ..Chromosome capping, therefore, is not strictly dependent on canonical capping proteins, such as Cdc13p, but can be achieved by alternate mechanisms...
  8. doi request reprint Differential participation of homologous recombination and nucleotide excision repair in yeast survival to ultraviolet light radiation
    Martin Toussaint
    Departement de Microbiologie et d Infectiologie, Faculte de Medecine, Universite de Sherbrooke, Sherbrooke, QC J1H 5N4, Canada
    Mutat Res 698:52-9. 2010
    ..Additional aims were to study the participation of HR and NER in promoting UV survival during the cell cycle, and to define the extent of the co-participation for both repair pathways...
  9. doi request reprint Introns within ribosomal protein genes regulate the production and function of yeast ribosomes
    Julie Parenteau
    Laboratoire de génomique fonctionnelle de l Université de Sherbrooke, Departement de Microbiologie et d Infectiologie, Faculte de Medecine et des Sciences de la Sante, Universite de Sherbrooke, Quebec, Canada
    Cell 147:320-31. 2011
    ..Together, our results indicate that splicing in yeast RP genes mediates intergene regulation and implicate the expression ratio of duplicated RP genes in modulating ribosome function...
  10. pmc A new telomerase RNA element that is critical for telomere elongation
    Nancy Laterreur
    Department of Microbiology and Infectious Diseases and Department of Biology, RNA Group, Universite de Sherbrooke, 3201, Rue Jean Mignault, Sherbrooke J1E 4K8, Canada
    Nucleic Acids Res 41:7713-24. 2013
    ..Given previous evidence for TeSS elements in ciliate and mammalian RNAs, we speculate that this substructure is a conserved feature that is required for optimal telomerase holoenzyme function. ..
  11. pmc Budding yeast telomerase RNA transcription termination is dictated by the Nrd1/Nab3 non-coding RNA termination pathway
    Jean François Noël
    RNA Group, Department of Microbiology and Infectious Diseases, Faculty of Medicine, Universite de Sherbrooke, 3001, 12e Ave Nord, Sherbrooke, Quebec, J1H 5N4, Canada
    Nucleic Acids Res 40:5625-36. 2012
    ....
  12. doi request reprint Abrupt telomere losses and reduced end-resection can explain accelerated senescence of Smc5/6 mutants lacking telomerase
    Jean François Noël
    Dept of Microbiology and Infectious Diseases, Faculty of Medicine, University of Sherbrooke, 3001, 12e Ave Nord, Sherbrooke, Qc J1J 1G2, Canada
    DNA Repair (Amst) 10:271-82. 2011
    ....
  13. ncbi request reprint DNA degradation at unprotected telomeres in yeast is regulated by the CDK1 (Cdc28/Clb) cell-cycle kinase
    Momchil D Vodenicharov
    Department of Microbiology, Faculty of Medicine, Universite de Sherbrooke, 3001 12e Ave Nord, Sherbrooke, Quebec J1H 5N4, Canada
    Mol Cell 24:127-37. 2006
    ..These results strongly suggest that after a loss of the telomere capping function, telomere-led genome instability is caused by tightly regulated cellular DNA repair attempts...
  14. ncbi request reprint Assessing telomeric phenotypes
    Catherine Lebel
    Department of Microbiology and Infectious Diseases, Faculty of Medicine, Universite de Sherbrooke, Quebec, Canada
    Methods Mol Biol 313:265-316. 2006
    ..However, growth phenotypes (senescence) and fine-structure analyses of the chromosome terminal DNA are also becoming increasingly important...
  15. pmc Telomerase is required to protect chromosomes with vertebrate-type T2AG3 3' ends in Saccharomyces cerevisiae
    Amadou Bah
    Departement de Microbiologie et d Infectiologie, Groupe ARN RNA Group, Faculte de Medecine et des Sciences de la Sante, Universite de Sherbrooke, 3001 12e Ave Nord, Sherbrooke, Quebec J1H 5N4, Canada
    J Biol Chem 286:27132-8. 2011
    ..These results show that in budding yeast the integrity of the 3' overhang is required for proper termination of telomere replication as well as protection...
  16. pmc The generation of proper constitutive G-tails on yeast telomeres is dependent on the MRX complex
    Michel Larrivée
    Departement De Microbiologie et Infectiologie, Groupe ARN RNA Group, Faculte de Medecine, Universite de Sherbrooke, Sherbrooke, J1H 5N4 Canada
    Genes Dev 18:1391-6. 2004
    ..Thus, G-tails are present on yeast chromosomes throughout the cell cycle and the MRX complex is required for their normal establishment...
  17. ncbi request reprint A mutation in yeast Tel1p that causes differential effects on the DNA damage checkpoint and telomere maintenance
    Mikhail Chakhparonian
    Department of Microbiology and Infectious Diseases, Faculty of Medicine, Universite de Sherbrooke, 3001 12e Ave Nord, Sherbrooke, QC, J1H 5N4, Canada
    Curr Genet 48:310-22. 2005
    ..The results thus strongly suggest that the different cellular pathways affected by Tel1p do not require the same level of Tel1p activity to be fully functional...
  18. pmc Genome-wide mapping of DNA strand breaks
    Frederic Leduc
    Departement de Biochimie, Faculte de Medecine et des Sciences de la Sante, Universite de Sherbrooke, Sherbrooke, Quebec, Canada
    PLoS ONE 6:e17353. 2011
    ..This mapping technique could find several applications for instance in the study of aging, genotoxic drug screening, cancer, meiosis, radiation and oxidative DNA damage...
  19. ncbi request reprint The cell division cycle puts up with unprotected telomeres: cell cycle regulated telomere uncapping as a means to achieve telomere homeostasis
    Momchil D Vodenicharov
    Department of Microbiology, Faculty of Medicine, Universite, de Sherbrooke, Sherbrooke, Quebec, Canada
    Cell Cycle 6:1161-7. 2007
    ..Thus, a temporally limited state of telomere dysfunction leading to chromosome end processing may represent a well-governed cell cycle event that constitutes an integral part of the assembly of a new functional telomere...
  20. doi request reprint Alternative splicing of SYK regulates mitosis and cell survival
    Panagiotis Prinos
    Laboratoire de Génomique Fonctionnelle, Universite de Sherbrooke, Sherbrooke, Quebec, Canada
    Nat Struct Mol Biol 18:673-9. 2011
    ..The data suggest that splicing of selected genes is specifically modified during tumor development to allow the expression of isoforms that promote cancer cell survival...
  21. ncbi request reprint Two-dimensional agarose gel analysis of DNA replication intermediates
    Alain T Dandjinou
    Department of Medical Microbiology and Infectious Diseases, Faculty of Medicine, Universite de Sherbrooke, Quebec, Canada
    Methods Mol Biol 313:193-208. 2006
    ..The 2-D gel is then blotted and probed to allow an examination of replication intermediates in specific DNA regions...
  22. doi request reprint UV-induced DNA damage and DNA repair in ribosomal genes chromatin
    Julie Pelloux
    Departement De Microbiologie et Infectiologie, Faculte de Medecine, Universite de Sherbrooke, Sherbrooke, QC, Canada
    Methods Mol Biol 809:303-20. 2012
    ..Using this approach, we have shown that NER is faster in nonnucleosomes vs. nucleosomes rDNA, that the formation of CPDs promotes changes in the active rDNA chromatin, and that NER is coupled to rRNA genes transcription...
  23. pmc TLC1 RNA nucleo-cytoplasmic trafficking links telomerase biogenesis to its recruitment to telomeres
    Franck Gallardo
    Departement de Biochimie, Universite de Montreal, Montreal, Quebec, Canada
    EMBO J 27:748-57. 2008
    ..Altogether, our results reveal that the nucleo-cytoplasmic trafficking of the TLC1 RNA is an important step in telomere homeostasis, and link telomerase biogenesis to its recruitment to telomeres...
  24. ncbi request reprint Telomeres: what's new at your end?
    Catherine Lebel
    Department of Microbiology and Infectious Diseases, Universite de Sherbrooke, Sherbrooke, QC J1H 5N4, Canada
    J Cell Sci 118:2785-8. 2005
  25. pmc Deletion of many yeast introns reveals a minority of genes that require splicing for function
    Julie Parenteau
    Laboratoire de génomique fonctionnelle de l Université de Sherbrooke, Departement de Microbiologie et d Infectiologie, Faculte de Medecine et des Sciences de la Sante, Universite de Sherbrooke, Sherbrooke, QC J1H 5N4, Canada
    Mol Biol Cell 19:1932-41. 2008
    ....
  26. ncbi request reprint A high-throughput method to measure the sensitivity of yeast cells to genotoxic agents in liquid cultures
    Martin Toussaint
    Departement de Microbiologie et d Infectiologie, Faculte de Medecine, Universite de Sherbrooke, Sherbrooke, Que J1H 5N4, Canada
    Mutat Res 606:92-105. 2006
    ..This new protocol is sensitive, provides quantifiable data, offers increased screening capability and speed compared to the colony formation test...
  27. ncbi request reprint A new link for a linker histone
    Antonio Conconi
    Department de Microbiologie et Infectiologie, Universite de Sherbrooke, Sherbrooke, Quebec, J1H 5N4 Canada
    Mol Cell 11:1421-3. 2003
    ..Remarkably, yeast histone H1 may not comply, as it appears to regulate homologous recombination specifically...
  28. pmc Maintenance of double-stranded telomeric repeats as the critical determinant for cell viability in yeast cells lacking Ku
    Serge Gravel
    Department of Microbiology, RNA Group Groupe ARN, Faculty of Medicine, Universite de Sherbrooke, Sherbrooke, Quebec J1H 5N4, Canada
    Mol Cell Biol 22:2182-93. 2002
    ..Thus, we hypothesize that an aspect of the coordinated synthesis of double-stranded telomeric repeats is sensitive to elevated temperatures...
  29. pmc Limited TTP supply affects telomere length regulation in a telomerase-independent fashion
    Martin Toussaint
    Department of Microbiology and Infectious Diseases, Faculty of Medicine, Université de Sherbrooke 3001, 12 Ave Nord, Sherbrooke, Quebec, J1H 5N4, Canada
    Nucleic Acids Res 33:704-13. 2005
    ..These results thus re-emphasize the importance of the interplay between conventional replication and telomerase-mediated addition of telomeric repeats in telomere replication...
  30. pmc Humanized telomeres and an attempt to express a functional human telomerase in yeast
    Amadou Bah
    Department of Microbiology and Infectiology, ARN RNA Group, Faculty of Medicine, Universite de Sherbrooke, Sherbrooke, Canada
    Nucleic Acids Res 32:1917-27. 2004
    ..The results suggest that vertebrate repeats on yeast telomeres are subject to a very high degree of repeat turnover and show that an innermost tract of 50 bp of yeast repeats are resistant to replacement...
  31. pmc Everything you ever wanted to know about Saccharomyces cerevisiae telomeres: beginning to end
    Raymund J Wellinger
    Department of Microbiology and Infectiology, RNA Group, Faculty of Medicine, Universite de Sherbrooke, Sherbrooke, QC J1H 5N4, Canada
    Genetics 191:1073-105. 2012
    ..We present a comprehensive review of yeast telomere biology that covers capping, replication, recombination, and transcription. We think of it as yeast telomeres--soup to nuts...
  32. ncbi request reprint Telomere maintenance and DNA replication: how closely are these two connected?
    Mikhail Chakhparonian
    Department of Microbiology and Infectiology, Faculty of Medicine, Universite de Sherbrooke, 3001 12th Ave N, Sherbrooke QC, Canada J1H 5N4
    Trends Genet 19:439-46. 2003
    ....
  33. ncbi request reprint Targeting heterogeneous nuclear ribonucleoparticule A1 and A2 proteins by RNA interference promotes cell death in transformed but not in normal mouse cell lines
    Caroline Patry
    Departement de Microbiologie et d Infectiologie, Faculte de Medecine, Universite de Sherbrooke, 3001 12th Avenue Nord, Sherbrooke, Quebec J1H 5N4, Canada
    Mol Cancer Ther 3:1193-9. 2004
    ..These results firmly establish A1 and A2 as proteins required for the viability of transformed murine and human cells, irrespective of the status of telomerase expression or the length of the double-stranded telomeric repeat...
  34. ncbi request reprint Exposing secrets of telomere-telomerase encounters
    Jean François Noël
    Department of Microbiology and Infectiology, Faculty of Medicine and Health Sciences, Universite de Sherbrooke, Sherbrooke, Québec J1E 4K8, Canada
    Cell 150:453-4. 2012
    ..In human cells, this interaction is mediated by Cajal bodies as matchmaker, and now Zhong et al. reveal molecular determinants that establish good chemistry between the two partners...
  35. ncbi request reprint [The structures at the termini of chromosomes: what is there hidden under the cap ?]
    Catherine Lebel
    Departement de Microbiologie et d Infectiologie, Faculte de Medecine, Universite de Sherbrooke, 3001, 12e Avenue Nord, Sherbrooke, Quebec, J1H 5N4, Canada
    Med Sci (Paris) 20:207-12. 2004
    ..Therefore, telomeres, and particularly their terminal DNA structures, are critical for the integrity of the genome...
  36. ncbi request reprint A phylogenetically based secondary structure for the yeast telomerase RNA
    Alain T Dandjinou
    Groupe ARN RNA Group, Department of Microbiology and Infectious Diseases, Faculty of Medicine, Universite de Sherbrooke, 3001 12th Avenue N, Sherbrooke, QC J1H 5N4, Canada
    Curr Biol 14:1148-58. 2004
    ..In contrast, the yeast telomerase RNA could not be fitted to any known structural model, and the limited number of known sequences from Saccharomyces species did not permit the prediction of a yeast specific conserved structure...
  37. doi request reprint Identification of alternative splicing markers for breast cancer
    Julian P Venables
    Laboratoire de génomique fonctionnelle de l Université de Sherbrooke, Quebec, Canada
    Cancer Res 68:9525-31. 2008
    ..These results provide a simple alternative for the classification of normal and cancerous breast tumor tissues and underscore the putative role of alternative splicing in the biology of cancer...