Jun Feng Wang

Summary

Country: Canada

Publications

  1. doi Mood stabilizer lithium inhibits amphetamine-increased 4-hydroxynonenal-protein adducts in rat frontal cortex
    Hua Tan
    BCMHARI, Department of Psychiatry, University of British Columbia, Vancouver, Canada
    Int J Neuropsychopharmacol 15:1275-85. 2012
  2. ncbi Defects of mitochondrial electron transport chain in bipolar disorder: implications for mood-stabilizing treatment
    Jun Feng Wang
    Department of Psychiatry, University of British Columbia, Vancouver
    Can J Psychiatry 52:753-62. 2007
  3. doi Increased oxidative stress in the anterior cingulate cortex of subjects with bipolar disorder and schizophrenia
    Jun Feng Wang
    Department of Psychiatry, University of British Columbia, 2255 Wesbrook Mall, Vancouver, BC V6T 2A1, Canada
    Bipolar Disord 11:523-9. 2009
  4. doi Decreased levels of glutathione, the major brain antioxidant, in post-mortem prefrontal cortex from patients with psychiatric disorders
    Jeremy W Gawryluk
    Department of Psychiatry, University of British Columbia, Vancouver, BC, Canada
    Int J Neuropsychopharmacol 14:123-30. 2011
  5. ncbi Identification of lithium-regulated genes in cultured lymphoblasts of lithium responsive subjects with bipolar disorder
    Xiujun Sun
    Department of Psychiatry, University of Toronto, Toronto, Canada
    Neuropsychopharmacology 29:799-804. 2004
  6. doi Abstinence from repeated amphetamine treatment induces depressive-like behaviors and oxidative damage in rat brain
    Yi Che
    Department of Psychiatry, University of British Columbia, Vancouver, Canada
    Psychopharmacology (Berl) 227:605-14. 2013
  7. doi Prefrontal cortex glutathione S-transferase levels in patients with bipolar disorder, major depression and schizophrenia
    Jeremy W Gawryluk
    Department of Psychiatry, University of British Columbia, Vancouver, BC, Canada
    Int J Neuropsychopharmacol 14:1069-74. 2011
  8. doi Mitochondrial complex I activity and oxidative damage to mitochondrial proteins in the prefrontal cortex of patients with bipolar disorder
    Ana C Andreazza
    Department of Psychiatry, University of British Columbia, 2255 Wesbrook Mall, Vancouver, BC V6T 2A1, Canada
    Arch Gen Psychiatry 67:360-8. 2010
  9. ncbi Regulation of GAP-43 expression by chronic desipramine treatment in rat cultured hippocampal cells
    Biao Chen
    Department of Psychiatry, McMaster University, Hamilton, Canada
    Biol Psychiatry 53:530-7. 2003
  10. ncbi Applying molecular approaches to understand the etiology and treatment of bipolar disorder
    L Trevor Young
    Can J Psychiatry 52:751-2. 2007

Collaborators

Detail Information

Publications19

  1. doi Mood stabilizer lithium inhibits amphetamine-increased 4-hydroxynonenal-protein adducts in rat frontal cortex
    Hua Tan
    BCMHARI, Department of Psychiatry, University of British Columbia, Vancouver, Canada
    Int J Neuropsychopharmacol 15:1275-85. 2012
    ..This finding also indicates that prevention of 4-HNE-VMAT2 adduction may contribute in part to the pharmacological action of lithium for the treatment of bipolar disorder...
  2. ncbi Defects of mitochondrial electron transport chain in bipolar disorder: implications for mood-stabilizing treatment
    Jun Feng Wang
    Department of Psychiatry, University of British Columbia, Vancouver
    Can J Psychiatry 52:753-62. 2007
    ..Our objective is to review the most recent findings regarding this research...
  3. doi Increased oxidative stress in the anterior cingulate cortex of subjects with bipolar disorder and schizophrenia
    Jun Feng Wang
    Department of Psychiatry, University of British Columbia, 2255 Wesbrook Mall, Vancouver, BC V6T 2A1, Canada
    Bipolar Disord 11:523-9. 2009
    ..Because the mitochondrial electron transport chain is a major source for production of reactive oxygen species that cause oxidative stress, we sought to determine in the present study if BD is associated with oxidative stress...
  4. doi Decreased levels of glutathione, the major brain antioxidant, in post-mortem prefrontal cortex from patients with psychiatric disorders
    Jeremy W Gawryluk
    Department of Psychiatry, University of British Columbia, Vancouver, BC, Canada
    Int J Neuropsychopharmacol 14:123-30. 2011
    ..Since oxidative damage has been demonstrated in MDD, BD, and SCZ, our finding that GSH levels are reduced in post-mortem prefrontal cortex suggests that these patient groups may be more susceptible to oxidative stress...
  5. ncbi Identification of lithium-regulated genes in cultured lymphoblasts of lithium responsive subjects with bipolar disorder
    Xiujun Sun
    Department of Psychiatry, University of Toronto, Toronto, Canada
    Neuropsychopharmacology 29:799-804. 2004
    ..Our findings indicate that alpha1B-AR may play an important role in the mechanism of action of lithium treatment...
  6. doi Abstinence from repeated amphetamine treatment induces depressive-like behaviors and oxidative damage in rat brain
    Yi Che
    Department of Psychiatry, University of British Columbia, Vancouver, Canada
    Psychopharmacology (Berl) 227:605-14. 2013
    ..Previously, we found that repeated treatment with amphetamine for 2 weeks induced oxidative stress in rat brain...
  7. doi Prefrontal cortex glutathione S-transferase levels in patients with bipolar disorder, major depression and schizophrenia
    Jeremy W Gawryluk
    Department of Psychiatry, University of British Columbia, Vancouver, BC, Canada
    Int J Neuropsychopharmacol 14:1069-74. 2011
    ..These data suggest that GST Mu may be a target for mood stabilizers...
  8. doi Mitochondrial complex I activity and oxidative damage to mitochondrial proteins in the prefrontal cortex of patients with bipolar disorder
    Ana C Andreazza
    Department of Psychiatry, University of British Columbia, 2255 Wesbrook Mall, Vancouver, BC V6T 2A1, Canada
    Arch Gen Psychiatry 67:360-8. 2010
    ..It remains unclear whether mitochondrial dysfunction, specifically complex I impairment, is associated with increased oxidative damage and, if so, whether this relationship is specific to bipolar disorder...
  9. ncbi Regulation of GAP-43 expression by chronic desipramine treatment in rat cultured hippocampal cells
    Biao Chen
    Department of Psychiatry, McMaster University, Hamilton, Canada
    Biol Psychiatry 53:530-7. 2003
    ..Identification of novel targets for antidepressants in hippocampus is important to understanding their therapeutic effects...
  10. ncbi Applying molecular approaches to understand the etiology and treatment of bipolar disorder
    L Trevor Young
    Can J Psychiatry 52:751-2. 2007
  11. pmc Neuron somal size is decreased in the lateral amygdalar nucleus of subjects with bipolar disorder
    Yarema B Bezchlibnyk
    The Vivian Rakoff Mood Disorders Lab, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    J Psychiatry Neurosci 32:203-10. 2007
    ..Morphometric studies of postmortem brains from subjects with mood disorders have reported altered density of glial cells in the amygdala; however, the nuclear regions have not been examined individually...
  12. ncbi Decreased expression of insulin-like growth factor binding protein 2 in the prefrontal cortex of subjects with bipolar disorder and its regulation by lithium treatment
    Yarema B Bezchlibnyk
    The Vivian Rakoff Mood Disorders Lab, Centre for Addiction and Mental Health, Toronto, ON, Canada
    Brain Res 1147:213-7. 2007
    ..These results suggest a role for IGFBPs in the etiology and pharmacotherapy of mood disorders...
  13. ncbi Immunoreactivity of 43 kDa growth-associated protein is decreased in post mortem hippocampus of bipolar disorder and schizophrenia
    Simon Y Tian
    The Vivian Rakoff Mood Disorders Laboratory, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Neurosci Lett 411:123-7. 2007
    ..These results suggest that impairment of neuroplasticity may occur in the hippocampus of bipolar disorder and schizophrenia patients...
  14. pmc Downregulation in components of the mitochondrial electron transport chain in the postmortem frontal cortex of subjects with bipolar disorder
    Xiujun Sun
    The Vivian Rakoff Mood Disorders Laboratory, Centre for Addiction and Mental Health, and Department of Psychiatry, University of Toronto, Toronto, Ont, Canada
    J Psychiatry Neurosci 31:189-96. 2006
    ..In this study, we used DNA microarray technology to analyze gene-expression profiles in the postmortem frontal cortex of subjects with BD...
  15. ncbi Chronic restraint stress decreases the expression of glutathione S-transferase pi2 in the mouse hippocampus
    Tatiana F Ejchel-Cohen
    The Vivian Rakoff Mood Disorders Laboratory, Centre for Addiction and Mental Health, and Department of Psychiatry, University of Toronto, Toronto, ON, Canada M5T 1R8
    Brain Res 1090:156-62. 2006
    ..Those regions are affected by stress, and our results could help understand further the mechanisms involved in the occurrence of stress-related disorders...
  16. ncbi Mood stabilizing drug lithium increases expression of endoplasmic reticulum stress proteins in primary cultured rat cerebral cortical cells
    Li Shao
    The Vivian Rakoff Mood Disorders Laboratory, Centre for Addiction and Mental Health, 250 College Street, Room 1105, Toronto, Ontario, Canada, M5T 1R8
    Life Sci 78:1317-23. 2006
    ..These results also suggest that the mechanism of GRP78 increase induced by lithium and valproate may be different from that of thapsigargin...
  17. ncbi Chronic treatment with mood stabilizers lithium and valproate prevents excitotoxicity by inhibiting oxidative stress in rat cerebral cortical cells
    Li Shao
    The Vivian Rakoff Mood Disorders Laboratory, Centre for Addiction and Mental Health, and Department of Psychiatry, University of Toronto, Ontario, Canada
    Biol Psychiatry 58:879-84. 2005
    ..In this study, we aimed to determine whether inhibiting oxidative damage plays a role in a neuroprotective effect of lithium and valproate against excitotoxicity...
  18. ncbi Glutathione S-transferase is a novel target for mood stabilizing drugs in primary cultured neurons
    Jun Feng Wang
    Centre for Addiction and Mental Health, and Department of Psychiatry, University of Toronto, Ontario, Canada
    J Neurochem 88:1477-84. 2004
    ..The present findings suggest that regulation of GST M1, and possibly GST A4, may mediate the anti-oxidative effects of valproate treatment, and regulation of GST may be involved in the mood stabilizing effect of valproate and lithium...
  19. ncbi Regulation of ER stress proteins by valproate: therapeutic implications
    Christopher D Bown
    Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ontario, Canada
    Bipolar Disord 4:145-51. 2002
    ..This paper reviews results of our studies examining the regulation of endoplasmic reticulum (ER) stress proteins by valproate (VPA). and discusses the possible implications in bipolar disorder...