- Iloperidone (Fanapt®), a novel atypical antipsychotic, is a potent HERG blocker and delays cardiac ventricular repolarization at clinically relevant concentrationPatrick Vigneault
Faculte de Pharmacie, Universite Laval, Quebec QC, Canada
Pharmacol Res 66:60-5. 2012..Patients are at increased risk of cardiac proarrhythmia during iloperidone treatment, as this drug possesses significant cardiac repolarization-delaying properties at clinically relevant concentration...
- Galantamine (Reminyl) delays cardiac ventricular repolarization and prolongs the QT interval by blocking the HERG currentPatrick Vigneault
Faculte de Pharmacie, Universite Laval, Pavillon Ferdinand Vandry, 1050 avenue de la Medecine, Quebec QC, Canada G1V 0A6
Eur J Pharmacol 681:68-74. 2012..Galantamine is a weak HERG blocker. This contributes to its mild QT-prolonging effect. Patients could be at risk of cardiac proarrhythmia during drug overdosage or interactions involving cytochrome 2D6 drug-metabolizing enzyme...
- QRS widening and QT prolongation under bupropion: a unique cardiac electrophysiological profileBertrand Caillier
Centre de Recherche de l Institut Universitaire de Cardiologie et de Pneumologie de Quebec, Quebec QC, Canada
Fundam Clin Pharmacol 26:599-608. 2012..Unlike class I anti-arrhythmics, bupropion causes cardiac conduction disturbances by reducing cardiac intercellular coupling...
- Prolongation of cardiac ventricular repolarization under paliperidone: how and how much?Patrick Vigneault
Faculte de Pharmacie, Universite Laval, Quebec, Canada
J Cardiovasc Pharmacol 57:690-5. 2011..Paliperidone (9-hydroxyrisperidone) is a second-generation antipsychotic. As observed with risperidone, QT interval prolongation was reported with paliperidone...