Subodh Verma

Summary

Country: Canada

Publications

  1. pmc BRCA1 is an essential regulator of heart function and survival following myocardial infarction
    Praphulla C Shukla
    Division of Cardiac Surgery, Department of Surgery, St Michael s Hospital, Toronto, Ontario M5B 1W8, Canada
    Nat Commun 2:593. 2011
  2. pmc Effects on duration of post-operative ischemia and patterns of blood flow recovery in different conditions of mouse hind limb ischemia
    Husain A Al-Mubarak
    Peripheral Vascular Disease Research Chair and The Stem Cell Unit, College of Medicine, King Saud University, Riyadh, Saudi Arabia
    Vasc Cell 3:14. 2011
  3. ncbi request reprint Cyclooxygenase-2 blockade does not impair endothelial vasodilator function in healthy volunteers: randomized evaluation of rofecoxib versus naproxen on endothelium-dependent vasodilatation
    S Verma
    Division of Cardiac Surgery, University of Toronto, Toronto, Ontario, Canada
    Circulation 104:2879-82. 2001
  4. ncbi request reprint Is C-reactive protein an innocent bystander or proatherogenic culprit? C-reactive protein promotes atherothrombosis
    Subodh Verma
    Division of Cardiac Surgery, St Michael s Hospital, University of Toronto, Toronto, Canada
    Circulation 113:2135-50; discussion 2150. 2006
  5. pmc The vascular biology of peroxisome proliferator-activated receptors: modulation of atherosclerosis
    Subodh Verma
    Division of Cardiac Surgery, St Michael s Hospital, Toronto, Ontario
    Can J Cardiol 22:12B-17B. 2006
  6. ncbi request reprint Resistin promotes endothelial cell activation: further evidence of adipokine-endothelial interaction
    Subodh Verma
    Division of Cardiac Surgery, Toronto General Hospital, 14EN 215, 200 Elizabeth St, Toronto, Ontario, Canada M5G 2C4
    Circulation 108:736-40. 2003
  7. ncbi request reprint C-reactive protein comes of age
    Subodh Verma
    Division of Cardiac Surgery, Toronto General Hospital, University of Toronto, ON, Canada
    Nat Clin Pract Cardiovasc Med 2:29-36; quiz 58. 2005
  8. ncbi request reprint C-reactive protein and atherothrombosis--beyond a biomarker: an actual partaker of lesion formation
    Subodh Verma
    Division of Cardiac Surgery, Toronto General Hospital, 14EN 215, 200 Elizabeth St, Toronto, Ontario, Canada M5G 2C4
    Am J Physiol Regul Integr Comp Physiol 285:R1253-6; discussion R1257-8. 2003
  9. ncbi request reprint The relationship between soluble CD40 ligand levels and Framingham coronary heart disease risk score in healthy volunteers
    Subodh Verma
    Division of Cardiac Surgery, Toronto General Hospital, 14 EN 215, 200 Elizabeth Street, Toronto, Ont, Canada M5G 2C4
    Atherosclerosis 182:361-5. 2005
  10. ncbi request reprint Endothelial function: ready for prime time?
    Subodh Verma
    Division of Cardiac Surgery, University of Toronto, Toronto, Canada
    Can J Cardiol 20:1335-9. 2004

Detail Information

Publications100

  1. pmc BRCA1 is an essential regulator of heart function and survival following myocardial infarction
    Praphulla C Shukla
    Division of Cardiac Surgery, Department of Surgery, St Michael s Hospital, Toronto, Ontario M5B 1W8, Canada
    Nat Commun 2:593. 2011
    ..BRCA1 mutation carriers, in addition to risk of breast and ovarian cancer, may be at a previously unrecognized risk of cardiac failure...
  2. pmc Effects on duration of post-operative ischemia and patterns of blood flow recovery in different conditions of mouse hind limb ischemia
    Husain A Al-Mubarak
    Peripheral Vascular Disease Research Chair and The Stem Cell Unit, College of Medicine, King Saud University, Riyadh, Saudi Arabia
    Vasc Cell 3:14. 2011
    ..abstract:..
  3. ncbi request reprint Cyclooxygenase-2 blockade does not impair endothelial vasodilator function in healthy volunteers: randomized evaluation of rofecoxib versus naproxen on endothelium-dependent vasodilatation
    S Verma
    Division of Cardiac Surgery, University of Toronto, Toronto, Ontario, Canada
    Circulation 104:2879-82. 2001
    ..To investigate this matter, we examined the effects of 7 days of treatment with rofecoxib versus naproxen on endothelial function in healthy volunteers...
  4. ncbi request reprint Is C-reactive protein an innocent bystander or proatherogenic culprit? C-reactive protein promotes atherothrombosis
    Subodh Verma
    Division of Cardiac Surgery, St Michael s Hospital, University of Toronto, Toronto, Canada
    Circulation 113:2135-50; discussion 2150. 2006
  5. pmc The vascular biology of peroxisome proliferator-activated receptors: modulation of atherosclerosis
    Subodh Verma
    Division of Cardiac Surgery, St Michael s Hospital, Toronto, Ontario
    Can J Cardiol 22:12B-17B. 2006
    ..In the present review, the vascular biology of PPARs, and how the modulation of these molecular pathways may serve as a therapeutic strategy to prevent atherosclerosis, vascular inflammation and restenosis are discussed...
  6. ncbi request reprint Resistin promotes endothelial cell activation: further evidence of adipokine-endothelial interaction
    Subodh Verma
    Division of Cardiac Surgery, Toronto General Hospital, 14EN 215, 200 Elizabeth St, Toronto, Ontario, Canada M5G 2C4
    Circulation 108:736-40. 2003
    ..Adipocyte-derived hormones may represent a mechanism linking insulin resistance to cardiovascular disease. In the present study, we evaluated the direct effects of resistin, a novel adipocyte-derived hormone, on endothelial activation...
  7. ncbi request reprint C-reactive protein comes of age
    Subodh Verma
    Division of Cardiac Surgery, Toronto General Hospital, University of Toronto, ON, Canada
    Nat Clin Pract Cardiovasc Med 2:29-36; quiz 58. 2005
    ..Thus, it might also serve as a therapeutic target. It is our contention that the future will see much wider use of CRP and CRP-driven therapies in clinical medicine, improving our ability to identify and manage cardiovascular disease...
  8. ncbi request reprint C-reactive protein and atherothrombosis--beyond a biomarker: an actual partaker of lesion formation
    Subodh Verma
    Division of Cardiac Surgery, Toronto General Hospital, 14EN 215, 200 Elizabeth St, Toronto, Ontario, Canada M5G 2C4
    Am J Physiol Regul Integr Comp Physiol 285:R1253-6; discussion R1257-8. 2003
  9. ncbi request reprint The relationship between soluble CD40 ligand levels and Framingham coronary heart disease risk score in healthy volunteers
    Subodh Verma
    Division of Cardiac Surgery, Toronto General Hospital, 14 EN 215, 200 Elizabeth Street, Toronto, Ont, Canada M5G 2C4
    Atherosclerosis 182:361-5. 2005
    ..Long-term follow-up of the FATE study will shed light on whether the predictive value of sCD40L is independent of Framingham based global risk assessment...
  10. ncbi request reprint Endothelial function: ready for prime time?
    Subodh Verma
    Division of Cardiac Surgery, University of Toronto, Toronto, Canada
    Can J Cardiol 20:1335-9. 2004
    ....
  11. ncbi request reprint Should radial arteries be used routinely for coronary artery bypass grafting?
    Subodh Verma
    Division of Cardiac Surgery, Toronto General Hospital, Toronto, ON, M5G 2C4, Canada
    Circulation 110:e40-6. 2004
  12. ncbi request reprint C-reactive protein activates the nuclear factor-kappaB signal transduction pathway in saphenous vein endothelial cells: implications for atherosclerosis and restenosis
    Subodh Verma
    Division of Cardiac Surgery, Toronto General Hospital, University of Toronto, Ontario, Canada
    J Thorac Cardiovasc Surg 126:1886-91. 2003
    ..This study examines the direct effects of C-reactive protein on nuclear factor-kappaB activation and related mechanisms in saphenous vein endothelial cells...
  13. ncbi request reprint Off-pump coronary artery bypass surgery: fundamentals for the clinical cardiologist
    Subodh Verma
    Division of Cardiac Surgery, Toronto General Hospital, Toronto, Ontario, Canada
    Circulation 109:1206-11. 2004
  14. ncbi request reprint C-reactive protein attenuates endothelial progenitor cell survival, differentiation, and function: further evidence of a mechanistic link between C-reactive protein and cardiovascular disease
    Subodh Verma
    Division of Cardiac Surgery, Toronto General Hospital, 14EN 215, 200 Elizabeth St, Toronto, Ontario, Canada M5G 2C4
    Circulation 109:2058-67. 2004
    ..An elevated level of C-reactive protein (CRP) has emerged as one of the most powerful predictors of cardiovascular disease. However, the impact of CRP on EPC biology is unknown...
  15. ncbi request reprint Hyperglycemia potentiates the proatherogenic effects of C-reactive protein: reversal with rosiglitazone
    Subodh Verma
    Division of Cardiac Surgery, University of Toronto, Toronto General Hospital, 14 EN 215, 200 Elizabeth Street, Toronto, Ont, Canada M5G 2C4
    J Mol Cell Cardiol 35:417-9. 2003
    ..The direct proatherogenic actions of CRP are exaggerated in the hyperglycemic milieu, and attenuated by rosiglitazone. Elevated CRP levels in patients with diabetes may serve to uncover a severe proatherogenic phenotype...
  16. ncbi request reprint C-reactive protein: structure affects function
    Subodh Verma
    Division of Cardiac Surgery, University of Toronto, Toronto, Canada
    Circulation 109:1914-7. 2004
  17. ncbi request reprint Fundamentals of endothelial function for the clinical cardiologist
    Subodh Verma
    Division of Cardiac Surgery, University of Toronto, University of Calgary, Canada
    Circulation 105:546-9. 2002
  18. ncbi request reprint Endothelial function testing as a biomarker of vascular disease
    Subodh Verma
    Department of Cardiac Surgery, University of Toronto, Toronto, Ontario, Canada
    Circulation 108:2054-9. 2003
  19. ncbi request reprint A self-fulfilling prophecy: C-reactive protein attenuates nitric oxide production and inhibits angiogenesis
    Subodh Verma
    Division of Cardiac Surgery, Toronto General Hospital, University of Toronto, Toronto, Canada
    Circulation 106:913-9. 2002
    ....
  20. doi request reprint BRCA1 is a novel target to improve endothelial dysfunction and retard atherosclerosis
    Krishna K Singh
    Division of Cardiac Surgery, Li Ka Shing Knowledge Institute at St Michael s Hospital, Toronto, Ontario, Canada Keenan Research Centre, Li Ka Shing Knowledge Institute at St Michael s Hospital, Toronto, Ontario, Canada
    J Thorac Cardiovasc Surg 146:949-960.e4. 2013
    ..We hypothesized that BRCA1 limits endothelial cell apoptosis and dysfunction, and via this mechanism attenuates atherosclerosis...
  21. doi request reprint Adropin is a novel regulator of endothelial function
    Fina Lovren
    Division of Cardiac Surgery, St Michael s Hospital, Toronto, Ontario, Canada
    Circulation 122:S185-92. 2010
    ..Because vascular function and insulin sensitivity are closely related, we hypothesized that adropin may also exert direct effects on the endothelium...
  22. ncbi request reprint Rosiglitazone facilitates angiogenic progenitor cell differentiation toward endothelial lineage: a new paradigm in glitazone pleiotropy
    Chao Hung Wang
    Division of Cardiac Surgery, Toronto General Hospital, Toronto, Ontario, Canada
    Circulation 109:1392-400. 2004
    ..It is unknown whether PPAR-gamma agonists favorably modulate bone marrow (BM)-derived angiogenic progenitor cells (APCs) to promote endothelial lineage differentiation and early reendothelialization after vascular intervention...
  23. ncbi request reprint BRCA1 shields vascular smooth muscle cells from oxidative stress
    Fina Lovren
    Division of Cardiac Surgery, St Michael s Hospital, Toronto, Ontario, Canada Keenan Research Centre in the Li Ka Shing Knowledge Institute, St Michael s Hospital, Toronto, Ontario, Canada
    J Thorac Cardiovasc Surg 147:1946-55, 1955.e1. 2014
    ..We hypothesized that the breast cancer 1, early onset (BRCA1) gene that is involved in cellular resistance to DNA damage limits ROS production and oxidative stress in VSMCs...
  24. doi request reprint Angiotensin converting enzyme-2 confers endothelial protection and attenuates atherosclerosis
    Fina Lovren
    Division of Cardiac Surgery, St Michael s Hospital, Toronto, ON, Canada
    Am J Physiol Heart Circ Physiol 295:H1377-84. 2008
    ..ACE2-based treatment approaches may be a novel approach to limit aberrant vascular responses and atherothrombosis...
  25. ncbi request reprint Tetrahydrobiopterin deficiency exaggerates intimal hyperplasia after vascular injury
    Chao Hung Wang
    Division of Cardiac Surgery, St Michael s Hospital, 30 Bond St, Queen Wing, Suite 8 003H, Toronto, Ontario, Canada M5B 1W8
    Am J Physiol Regul Integr Comp Physiol 289:R299-304. 2005
    ..In summary, we describe, for the first time, that in vivo BH4 deficiency facilitates neointimal formation after vascular injury. Modulation of BH4 bioavailability is an important therapeutic target for restenosis...
  26. ncbi request reprint Combined endothelial and myocardial protection by endothelin antagonism enhances transplant allograft preservation
    Paul W M Fedak
    Toronto General Hospital, University Health Network, Division of Cardiac Surgery, University of Toronto, Toronto, Ontario, Canada
    J Thorac Cardiovasc Surg 129:407-15. 2005
    ..We hypothesized that endothelin antagonism during cardiac allograft storage would limit early endothelial dysfunction and improve myocardial performance after transplantation...
  27. ncbi request reprint Endothelin antagonism and interleukin-6 inhibition attenuate the proatherogenic effects of C-reactive protein
    Subodh Verma
    Division of Cardiac Surgery, Toronto General Hospital Research Institute, University of Toronto, Canada
    Circulation 105:1890-6. 2002
    ..In the present study, we examined the role of the potent endothelium-derived vasoactive factor endothelin-1 (ET-1) and the inflammatory cytokine interleukin-6 (IL-6) as mediators of CRP-induced proatherogenic processes...
  28. ncbi request reprint C-reactive protein upregulates complement-inhibitory factors in endothelial cells
    Shu Hong Li
    Division of Cardiac Surgery, Toronto General Hospital, Toronto, Ontario, Canada
    Circulation 109:833-6. 2004
    ....
  29. ncbi request reprint Hyperglycemia exaggerates ischemia-reperfusion-induced cardiomyocyte injury: reversal with endothelin antagonism
    Subodh Verma
    Division of Cardiac Surgery, Toronto General Hospital, University of Toronto, Toronto, Ontario, Canada
    J Thorac Cardiovasc Surg 123:1120-4. 2002
    ..Therefore we studied the effects of endothelin receptor blockers (BQ-123 and bosentan) on hyperglycemia-induced endothelin-1 production and cellular injury after ischemia-reperfusion...
  30. doi request reprint Microvascular function predicts cardiovascular events in primary prevention: long-term results from the Firefighters and Their Endothelium (FATE) study
    Todd J Anderson
    Department of Cardiac Sciences and Libin Cardiovascular Institute of Alberta, University of Calgary, 1403 29th St NW, Calgary, AB, Canada
    Circulation 123:163-9. 2011
    ..The purpose of the study was to determine the prognostic significance of endothelial function and other vascular markers in apparently healthy men...
  31. doi request reprint Lack of S100A1 in mice confers a gender-dependent hypertensive phenotype and increased mortality after myocardial infarction
    Jean Francois Desjardins
    Division of Cardiology, St Michael s Hospital, University of Toronto, 30 Bond St, Rm 6 044, Queen Wing, Toronto, ON, Canada M5B 1W8
    Am J Physiol Heart Circ Physiol 296:H1457-65. 2009
    ..Thus, absence of S100A1 results in acute functional impairment and high mortality after MI associated with a gender-specific hypertensive phenotype. S100A1 appears to play a role in the endothelium-dependent regulation of blood pressure...
  32. ncbi request reprint Endothelin blockade potentiates endothelial protective effects of ACE inhibitors in saphenous veins
    Lawrence Ko
    Division of Cardiac Surgery, The University of Toronto, Toronto General Hospital, Ontario, Canada
    Ann Thorac Surg 73:1185-8. 2002
    ..The effects of acute endothelin antagonism on endothelial function in saphenous vein from patients treated with and without angiotensin-converting enzyme inhibitors were compared...
  33. ncbi request reprint TIMP-3 deficiency leads to dilated cardiomyopathy
    Paul W M Fedak
    Division of Cardiac Surgery, University of Toronto, Toronto General Research Institute, Ontario, Canada
    Circulation 110:2401-9. 2004
    ....
  34. pmc Adiponectin primes human monocytes into alternative anti-inflammatory M2 macrophages
    Fina Lovren
    Division of Cardiac Surgery, Keenan Research Centre in Li Ka Shing Knowledge Institute of St Michael s Hospital, Toronto, Ontario, Canada
    Am J Physiol Heart Circ Physiol 299:H656-63. 2010
    ..Conditions associated with low adiponectin levels, such as visceral obesity and insulin resistance, may promote atherosclerosis, in part through aberrant macrophage kinetics...
  35. doi request reprint Identification and management of cardiometabolic risk in Canada: a position paper by the cardiometabolic risk working group (executive summary)
    Lawrence A Leiter
    St Michael s Hospital, Toronto, Ontario, Canada
    Can J Cardiol 27:124-31. 2011
    ..Health care professionals must also consider ethnicity-related risk factors in order to appropriately evaluate all individuals in their diverse patient populations...
  36. ncbi request reprint Increased endothelin-1 production in diabetic patients after cardioplegic arrest and reperfusion impairs coronary vascular reactivity: reversal by means of endothelin antagonism
    Subodh Verma
    Division of Cardiac Surgery, Toronto General Hospital, University of Toronto, Toronto, Ontario, Canada
    J Thorac Cardiovasc Surg 123:1114-9. 2002
    ....
  37. doi request reprint Regulating cardiac energy metabolism and bioenergetics by targeting the DNA damage repair protein BRCA1
    Krishna K Singh
    Division of Cardiac Surgery and Endocrinology, Li Ka Shing Knowledge Institute, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada
    J Thorac Cardiovasc Surg 146:702-9. 2013
    ..We hypothesized that the cardioprotective role of the breast cancer 1, early onset (BRCA1) gene might be mediated in part by alterations in cardiac bioenergetics...
  38. ncbi request reprint Preservation of heart function in diabetic rats by the combined effects of muscle cell implantation and insulin therapy
    Byung Ok Kim
    Toronto General Research Institute, Division of Cardiovascular Surgery, Toronto, Ontario, Canada
    Eur J Heart Fail 10:14-21. 2008
    ..Cell transplantation can prevent cardiac dilatation after injury, and may also prevent congestive heart failure in diabetic cardiomyopathy...
  39. ncbi request reprint MicroRNA-145 targeted therapy reduces atherosclerosis
    Fina Lovren
    Division of Cardiac Surgery, Li Ka Shing Knowledge Institute at St Michael s Hospital, Toronto, Ontario, Canada
    Circulation 126:S81-90. 2012
    ..Because microRNA-145 is highly expressed in vascular smooth muscle cells (VSMC) and regulates VSMC fate and plasticity, we hypothesized that it may be a novel regulator of atherosclerosis and plaque stability...
  40. doi request reprint Impaired endothelial function in C-reactive protein overexpressing mice
    Hwee Teoh
    Division of Cardiac Surgery, Keenan Research Centre, Li Ka Shing Knowledge Institute, St Michael s Hospital, University of Toronto, Toronto, ON, Canada
    Atherosclerosis 201:318-25. 2008
    ..These data further support a role for CRP in mediating endothelial dysfunction...
  41. ncbi request reprint C-Reactive protein upregulates receptor for advanced glycation end products expression in human endothelial cells
    Yun Zhong
    Toronto General Research Institute, Toronto, Ontario, Canada
    Hypertension 48:504-11. 2006
    ..Silencing of the RAGE gene prevents CRP-induced macrophage chemoattractant protein 1 activation. These data reinforce the mechanistic links among inflammation, endothelial dysfunction, and atherothrombosis...
  42. doi request reprint The differential association between various anthropometric indices of obesity and subclinical atherosclerosis
    Raymond T Yan
    Division of Cardiology, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada
    Atherosclerosis 207:232-8. 2009
    ..However, it remains undetermined whether indices of abdominal obesity are also more strongly associated with early subclinical atherosclerosis in asymptomatic individuals...
  43. doi request reprint Comparison of new measures of vascular function to flow mediated dilatation as a measure of cardiovascular risk factors
    Andrew C Philpott
    Libin Cardiovascular Institute, Department of Cardiac Sciences, University of Calgary, Calgary, Alberta, Canada
    Am J Cardiol 103:1610-5. 2009
    ..This may reflect greater sensitivity of these measures to detect early abnormalities associated with risk factors in a relatively young and healthy population...
  44. ncbi request reprint Cell transplantation preserves matrix homeostasis: a novel paracrine mechanism
    Paul W M Fedak
    Division of Cardiac Surgery, University of Toronto, Toronto General Research Institute, Toronto General Hospital, Toronto, Ontario, Canada
    J Thorac Cardiovasc Surg 130:1430-9. 2005
    ....
  45. ncbi request reprint C-reactive protein upregulates angiotensin type 1 receptors in vascular smooth muscle
    Chao Hung Wang
    Division of Cardiac Surgery, University of Toronto, Toronto, Ontario, Canada
    Circulation 107:1783-90. 2003
    ..Lastly, the effects of CRP (and losartan) on neointimal formation were examined in vivo in a rat carotid angioplasty model...
  46. pmc Adiponectin deficiency promotes endothelial activation and profoundly exacerbates sepsis-related mortality
    Hwee Teoh
    Div of Cardiovascular and Thoracic Surgery, St Michael s Hospital, Toronto, ON, Canada M5B 1W8
    Am J Physiol Endocrinol Metab 295:E658-64. 2008
    ..These data suggest a critical role of adiponectin as a modulator of survival and endothelial inflammation in experimental sepsis and a potential mechanistic link between adiposity and increased sepsis...
  47. ncbi request reprint Autophagy gene fingerprint in human ischemia and reperfusion
    Krishna K Singh
    Division of Cardiac Surgery, Keenan Research Centre in the Li Ka Shing Knowledge Institute at St Michael s Hospital, Toronto, Ontario, Canada
    J Thorac Cardiovasc Surg 147:1065-1072.e1. 2014
    ..We sought to define the autophagy gene fingerprint associated with human ischemia and reperfusion (IR) injury using an intraoperative model developed by Sellke and colleagues...
  48. doi request reprint miRNA-141 is a novel regulator of BMP-2-mediated calcification in aortic stenosis
    Bobby Yanagawa
    Division of Cardiac Surgery, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada
    J Thorac Cardiovasc Surg 144:256-62. 2012
    ..MicroRNAs (miRNAs) are essential post-transcriptional modulators of gene expression and miRNA-141 is a known repressor of BMP-2-mediated osteogenesis. We hypothesized that miRNA-141 is a key regulator of aortic valve calcification...
  49. ncbi request reprint Tetrahydrobiopterin attenuates homocysteine induced endothelial dysfunction
    Bikramjit Dhillon
    Division of Cardiac Surgery, University of Toronto, Toronto, Canada
    Mol Cell Biochem 247:223-7. 2003
    ..BH4 may represent an important target for strategies aimed at improving endothelial dysfunction secondary to hyperhomocysteinemia...
  50. ncbi request reprint Novel cardioprotective effects of tetrahydrobiopterin after anoxia and reoxygenation: Identifying cellular targets for pharmacologic manipulation
    Subodh Verma
    Division of Cardiac Surgery, Toronto General Hospital, Toronto, Ontario, Canada
    J Thorac Cardiovasc Surg 123:1074-83. 2002
    ..Measures of endothelial function, oxidant production, cell survival, and cardiac function were used to assess outcome...
  51. ncbi request reprint Evaluation of a novel sutureless anastomotic connector: from endothelial function to mid-term clinical and angiographic follow-up
    Subodh Verma
    Division of Cardiovascular Surgery, Toronto General Hospital, University Health Network, Department of Surgery, University of Toronto, Ontario, Canada
    J Thorac Cardiovasc Surg 126:1555-60. 2003
    ..We evaluated the effect of the St Jude Medical sutureless anastomotic connector on endothelium-dependent and -independent saphenous vein graft relaxation, as well as on clinical outcomes and graft patency in patients...
  52. doi request reprint Knowledge, attitudes, and practice patterns in surgical management of bicuspid aortopathy: a survey of 100 cardiac surgeons
    Subodh Verma
    Division of Cardiac Surgery, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada
    J Thorac Cardiovasc Surg 146:1033-1040.e4. 2013
    ..We hypothesized that surgeons' knowledge of and attitudes toward bicuspid aortic valve aortopathy influence their surgical approaches...
  53. doi request reprint The relationship between anthropometric indexes of adiposity and vascular function in the FATE cohort
    Billie Jean Martin
    Department of Cardiac Sciences and Libin Cardiovascular Institute of Alberta, University of Calgary, Calgary, Alberta, Canada
    Obesity (Silver Spring) 21:266-73. 2013
    ..However, the correlation of these indexes with measures of vascular health remain poorly defined. This study investigated which measure of adiposity is most strongly associated with endothelial function...
  54. ncbi request reprint Cardiac remodeling and failure: from molecules to man (Part III)
    Paul W M Fedak
    Division of Cardiac Surgery, Toronto General Hospital, University of Toronto, Toronto, ON, Canada M5G 2C4
    Cardiovasc Pathol 14:109-19. 2005
    ..The following review outlines recent advances in medical and surgical approaches to control the remodeling process that underlies the progression of heart failure...
  55. doi request reprint Perceptions of Canadian primary care physicians towards cardiovascular risk assessment and lipid management
    Milan Gupta
    Canadian Cardiovascular Research Network, Brampton, Ontario, Canada
    Can J Cardiol 28:14-9. 2012
    ..This study was performed to gain insight into how Canadian primary care physicians (PCPs) incorporate traditional and emerging risk factors in determining risk...
  56. ncbi request reprint C-reactive protein alters antioxidant defenses and promotes apoptosis in endothelial progenitor cells
    Hiroko Fujii
    Toronto General Research Institute, St Michael s Hospital, University of Toronto, Canada
    Arterioscler Thromb Vasc Biol 26:2476-82. 2006
    ..In the present study, we evaluated the effects of CRP on antioxidative enzymes, reactive oxygen species production, telomerase activity, and apoptosis in human circulating EPCs...
  57. pmc A randomized, controlled trial of the effects of rosiglitazone on adipokines, and inflammatory and fibrinolytic markers in diabetic patients: study design and protocol
    Milan Gupta
    Division of Cardiovascular and Thoracic Surgery, St Michael s Hospital, University of Toronto, Toronto, Canada
    Can J Cardiol 24:e65-9. 2008
    ..Although rosiglitazone may offer vascular benefits beyond lowering glucose, recently, concern has been raised that this drug may paradoxically increase cardiovascular risk...
  58. ncbi request reprint Biomarkers of vascular disease linking inflammation to endothelial activation: Part II
    Paul E Szmitko
    Division of Cardiac Surgery, Toronto General Hospital, Toronto, Ontario, Canada M5G 2C4
    Circulation 108:2041-8. 2003
  59. ncbi request reprint Caveolin: a key target for modulating nitric oxide availability in health and disease
    Bikramjit Dhillon
    Division of Cardiac Surgery, Toronto General Hospital, University of Toronto, Toronto, ON, Canada
    Mol Cell Biochem 247:101-9. 2003
    ..Recognizing the potential of this specialized domain may provide the fundamental knowledge to target the endothelium in disease...
  60. ncbi request reprint Altered expression of disintegrin metalloproteinases and their inhibitor in human dilated cardiomyopathy
    Paul W M Fedak
    General Research Institute, Division of Cardiac Surgery, University of Toronto, Toronto General Hospital, Toronto, Ontario, Canada
    Circulation 113:238-45. 2006
    ..We compared expression of ADAMs, their endogenous inhibitor tissue inhibitor of metalloproteinases (TIMP)-3, and integrins in human heart tissue with varied patterns of structural remodeling...
  61. doi request reprint Plasma renin activity predicts cardiovascular mortality in the Heart Outcomes Prevention Evaluation (HOPE) study
    Subodh Verma
    Division of Cardiac Surgery, Keenan Research Centre in the Li Ka Shing Knowledge Institute of St Michael s, University of Toronto, Ontario, Canada
    Eur Heart J 32:2135-42. 2011
    ....
  62. ncbi request reprint Cardiac remodeling and failure From molecules to man (Part II)
    Paul W M Fedak
    Division of Cardiac Surgery, University of Toronto, Toronto General Hospital, 14EN 215, 200 Elizabeth Street, Toronto ON, Canada M5G 2C4
    Cardiovasc Pathol 14:49-60. 2005
    ....
  63. ncbi request reprint C-reactive protein incites atherosclerosis
    Subodh Verma
    Division of Cardiac Surgery, University of Toronto, Toronto, Ontario
    Can J Cardiol 20:29B-31B. 2004
    ..More recently, CRP has been demonstrated to inhibit the survival and differentiation of bone marrow-derived endothelial progenitor cells, which play a key role in postnatal neovascularization...
  64. ncbi request reprint Restoration and regeneration of failing myocardium with cell transplantation and tissue engineering
    Paul W M Fedak
    Division of Cardiac Surgery, Toronto General Hospital, Toronto, Ontario M5G 2C4, Canada
    Semin Thorac Cardiovasc Surg 15:277-86. 2003
    ....
  65. ncbi request reprint Glitazones and heart failure: critical appraisal for the clinician
    Chao Hung Wang
    Division of Cardiac Surgery, Toronto General Hospital, University of Toronto, Toronto, Canada
    Circulation 107:1350-4. 2003
  66. ncbi request reprint Cross-sectional evaluation of brachial artery flow-mediated vasodilation and C-reactive protein in healthy individuals
    Subodh Verma
    Division of Cardiac Surgery, Toronto General Hospital, Toronto, Canada
    Eur Heart J 25:1754-60. 2004
    ..The present study was designed to (a) examine the interrelationship between endothelial function and CRP in healthy individuals and (b) evaluate the relationship of each biomarker towards global Framingham risk scores...
  67. doi request reprint Herceptin, a recombinant humanized anti-ERBB2 monoclonal antibody, induces cardiomyocyte death
    Krishna K Singh
    Division of Cardiac Surgery, The Keenan Research Centre in the Li Ka Shing Knowledge Institute of St Michael s Hospital, Toronto, ON, Canada
    Biochem Biophys Res Commun 411:421-6. 2011
    ..These observations may have important therapeutic implications since they suggest that anticancer agents that inhibit MDM2 and its downstream actions may curb tumor progression at the expense of increasing cardiac stress...
  68. pmc Cardioprotective c-kit+ cells are from the bone marrow and regulate the myocardial balance of angiogenic cytokines
    Shafie Fazel
    Division of Cardiovascular Surgery, Toronto General Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada
    J Clin Invest 116:1865-77. 2006
    ..We conclude that, consistent with their documented role in tumorigenesis, bone marrow c-kit+ cells act as key regulators of the angiogenic switch in infarcted myocardium, thereby driving efficient cardiac repair...
  69. ncbi request reprint Fundamentals of reperfusion injury for the clinical cardiologist
    Subodh Verma
    Division of Cardiac Surgery, University of Toronto, Toronto, Canada
    Circulation 105:2332-6. 2002
  70. ncbi request reprint Suboptimal use of statin therapy in elderly patients with atherosclerosis: a population-based study
    Mohammed Al-Omran
    Division of Vascular Surgery, Toronto General Hospital, University of Toronto, Toronto, Ontario, Canada
    J Vasc Surg 48:607-12. 2008
    ..However, limited population-based data are available on use of statin therapy in these patients in Canada. We sought to study trends in statin use to treat these patients in Ontario during a 10-year period...
  71. ncbi request reprint Rationale and design of the Glitazones and the Endothelium (GATE) study: evaluation of rosiglitazone on endothelial function in patients with diabetes
    Jaroslav Hubacek
    University of Calgary, Calgary, Alberta, Canada
    Can J Cardiol 20:1449-53. 2004
    ....
  72. ncbi request reprint The effect of iron status on vascular health
    Leanne M Yunker
    Department of Medical Genetics, University of Calgary, Calgary, Alberta, Canada
    Vasc Med 11:85-91. 2006
    ..The present study does not support the hypothesis that mild to moderately increased iron stores are associated with enhanced atherosclerosis risk...
  73. ncbi request reprint Cardiology patient pages. Red wine and your heart
    Paul E Szmitko
    Division of Cardiac Surgery, Toronto General Hospital, Toronto, Ontario, Canada
    Circulation 111:e10-1. 2005
  74. ncbi request reprint Novel cardioprotective effects of pravastatin in human ventricular cardiomyocytes subjected to hypoxia and reoxygenation: beneficial effects of statins independent of endothelial cells
    Subodh Verma
    Division of Cardiac Surgery, Toronto General Hospital, University of Toronto, Ontario, Canada
    J Surg Res 119:66-71. 2004
    ..Statin therapy may restore ischemic hearts to full functional integrity during cardioplegic arrest through a direct effect on cardiomyocyte survival...
  75. ncbi request reprint New markers of inflammation and endothelial cell activation: Part I
    Paul E Szmitko
    Division of Cardiology, University of Calgary, Calgary, Alberta, Canada
    Circulation 108:1917-23. 2003
  76. ncbi request reprint Endothelial progenitor cells: new hope for a broken heart
    Paul E Szmitko
    Division of Cardiac Surgery, Toronto General Hospital, 14EN 215, 200 Elizabeth St, Toronto, Ontario, Canada M5G 2C4
    Circulation 107:3093-100. 2003
  77. ncbi request reprint Does ischemic preconditioning afford clinically relevant cardioprotection?
    Peter Mikhail
    Department of Surgery, Division of General Surgery, University of Toronto, Toronto, Canada
    Am J Cardiovasc Drugs 3:1-11. 2003
    ..which is cell death. Larger trials, with morbidity and mortality being with the primary endpoints, are needed to confirm the clinical relevance of ischemic preconditioning...
  78. ncbi request reprint Clinician guide to angiogenesis
    Neil P Fam
    Division of Cardiology, St Michael s Hospital, The University of Toronto, Toronto, Ontario, Canada
    Circulation 108:2613-8. 2003
  79. ncbi request reprint C-reactive protein and the metabolic syndrome: useful addition to the cardiovascular risk profile?
    Paul E Szmitko
    Division of General Internal Medicine, University of Toronto, Toronto, Ontario, Canada
    J Cardiometab Syndr 1:66-9; quiz 70-1. 2006
    ..A large ongoing trial is investigating whether statin therapy will decrease the risk of cardiovascular disease in patients with elevated levels of C-reactive protein and low-to-normal levels of low-density lipoprotein cholesterol...
  80. ncbi request reprint C-reactive protein and statins: IL-8 as a molecular link?
    Paul E Szmitko
    Division of General Internal Medicine, University of Toronto, Ontario, Canada
    Clin Sci (Lond) 108:493-5. 2005
    ....
  81. pmc Effect of angiotensin-converting enzyme inhibition on C-reactive protein levels: the ramipril C-reactive pRotein randomized evaluation (4R) trial results
    Subodh Verma
    Division of Cardiac Surgery, St Michael s Hospital, University of Toronto, Toronto
    Can J Cardiol 25:e236-40. 2009
    ..The effect of angiotensin-converting enzyme inhibitors on CRP levels has not been adequately studied...
  82. pmc The incretin system and cardiometabolic disease
    Paul E Szmitko
    Division of General Internal Medicine, St Michael s Hospital, University of Toronto, 30 Bond Street, Toronto, Ontario, Canada
    Can J Cardiol 26:87-95. 2010
    ..The influence of incretins on the cardiovascular system beyond the proatherogenic effect of type 2 diabetes will also be discussed...
  83. ncbi request reprint L-arginine protects human heart cells from low-volume anoxia and reoxygenation
    Noritsugu Shiono
    Division of Cardiac Surgery, University of Toronto, Toronto, Ontario, M5G 2C4 Canada
    Am J Physiol Heart Circ Physiol 282:H805-15. 2002
    ..In addition, L-arginine cardioprotection was achieved by the activation of guanylate cyclase, leading to increased cGMP levels in human heart cells. This action involves a glibenclamide-sensitive, NO-cGMP-dependent pathway...
  84. ncbi request reprint Ethnic diversity: South Asian ethnicity is associated with increased coronary artery bypass grafting mortality
    Stephanie J Brister
    Cardiovascular Surgery Division, University Health Network, Toronto General Hospital, Toronto, Ontario, Canada
    J Thorac Cardiovasc Surg 133:150-4. 2007
    ..However, the effect of South Asian ethnicity on clinical outcomes after cardiac surgery is unknown. Thus, we determined whether South Asian ethnicity is a predictor of a poorer outcome after coronary artery bypass grafting...
  85. ncbi request reprint Coenzyme Q(10) and congestive heart failure: what is the verdict?
    Satish R Raj
    University of Calgary, Calgary, Alberta, Canada
    Can J Cardiol 18:1054-8. 2002
  86. ncbi request reprint Nitric oxide-eluting polyurethanes--vascular grafts of the future?
    Subodh Verma
    Division of Cardiac Surgery, St Michael s Hospital and the University of Toronto, Toronto
    N Engl J Med 353:730-1. 2005
  87. pmc DNA damage repair and cardiovascular diseases
    Praphulla C Shukla
    Division of Cardiac Surgery, Richard Lewar Centre of Excellence in Cardiovascular Research, Toronto, Ontario, Canada
    Can J Cardiol 26:13A-16A. 2010
    ..A platform introduction to DNA repair/response are integrated, and insights into the future directions of this exciting field are offered...
  88. ncbi request reprint A novel technique to assess flow-mediated vasodilation
    Shafie Fazel
    J Am Coll Cardiol 44:1478-80. 2004
  89. ncbi request reprint Interaction of 5-methyltetrahydrofolate and tetrahydrobiopterin on endothelial function
    Mathew Eric Hyndman
    Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada T2N 4N1
    Am J Physiol Heart Circ Physiol 282:H2167-72. 2002
    ..superoxide) production and improve endothelial function. 5-Methyltetrahydrofolate may represent an important strategy for intervention aimed at improving tetrahydrobiopterin bioavailability...
  90. ncbi request reprint Endothelin Antagonism and Insulin's Vascular Effects
    Subodh Verma
    Hypertension 40:e12-3; author reply e12-3. 2002
  91. ncbi request reprint Inhibition of the renin-angiotensin system in cardiovascular protection: Is it important to watch your C'ARB' intake?
    Martin H Strauss
    Can J Cardiol 21:577-80. 2005
  92. ncbi request reprint C-reactive protein and reendothelialization: NO involvement
    Paul E Szmitko
    Circ Res 100:1405-7. 2007
  93. ncbi request reprint Does C-reactive protein predict saphenous vein graft patency?
    Hwee Teoh
    J Thorac Cardiovasc Surg 134:277-9. 2007
  94. ncbi request reprint Pioglitazone increases the numbers and improves the functional capacity of endothelial progenitor cells in patients with diabetes mellitus
    Chao Hung Wang
    Division of Cardiology, Department of Internal Medicine, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Keelung, Taiwan
    Am Heart J 152:1051.e1-8. 2006
    ..The number and function of circulating EPCs are altered in diabetics. This study sought to investigate whether the number and functional properties of EPCs from patients with type II diabetes could be improved by pioglitazone...
  95. ncbi request reprint Stem cell factor deficiency is vasculoprotective: unraveling a new therapeutic potential of imatinib mesylate
    Chao Hung Wang
    Cardiology and Internal Medicine, Chang Gung Memorial Hospital, Keelung, Taiwan
    Circ Res 99:617-25. 2006
    ..These data indicate that SCF/c-Kit signaling plays a pivotal role in the development of neointima by BM-derived PCs and that the inhibition of this pathway may serve as a novel therapeutic target to limit aberrant vascular remodeling...
  96. ncbi request reprint South Asians and cardiovascular risk: what clinicians should know
    Milan Gupta
    Division of Cardiology, William Osler Health Centre, McMaster University, Hamilton, Canada
    Circulation 113:e924-9. 2006
  97. ncbi request reprint Cyclosporine increases ischemia-induced endothelial progenitor cell mobilization through manipulation of the CD26 system
    Chao Hung Wang
    Division of Cardiology, Department of Internal Medicine, Chang Gung Memorial Hospital, 222, Mai Chin Road, Keelung, Taiwan
    Am J Physiol Regul Integr Comp Physiol 294:R811-8. 2008
    ..In summary, CsA manipulates the mobilization of EPCs into the circulation via the CD26/DPP IV system. Short-term CsA treatment has beneficial effects on angiogenesis of ischemic tissues...
  98. ncbi request reprint Serum interleukin-6 levels, not genotype, correlate with coronary plaque complexity
    Li Tang Kuo
    Cardiology Section, Department of Medicine, Chang Gung University College of Medicine, Chang Gung Memorial Hospital, Keelung, Taiwan
    Int Heart J 49:391-402. 2008
    ..005). A simple measurement of the serum IL-6 level in patients with CAD can potentially identify subjects with complex coronary lesions and provide the option of aggressive medical strategies in a clinical setting...
  99. ncbi request reprint Coxibs and the endothelium
    Subodh Verma
    J Am Coll Cardiol 42:1754-6. 2003
  100. ncbi request reprint Relationship between carotid artery intima-media thickness and brachial artery flow-mediated dilation in middle-aged healthy men
    Raymond T Yan
    Department of Medicine, Division of Cardiology, McMaster University, Hamilton, Ontario L8L 2X2, Canada
    J Am Coll Cardiol 45:1980-6. 2005
    ..We aimed to determine the relationship between carotid intima-media thickness (IMT) and brachial artery flow-mediated dilation (FMD) in healthy middle-age men...