Christine Vande Velde

Summary

Country: Canada

Publications

  1. pmc Misfolded SOD1 associated with motor neuron mitochondria alters mitochondrial shape and distribution prior to clinical onset
    Christine Vande Velde
    Centre d excellence en neuromique de l Université de Montréal, and Département de Médecine, Universite de Montreal, Montreal, Quebec, Canada
    PLoS ONE 6:e22031. 2011
  2. pmc Endogenous TDP-43, but not FUS, contributes to stress granule assembly via G3BP
    Anaïs Aulas
    Centre d excellence en neuromique de l Université de Montréal, Centre de recherche du Centre Hospitalier de l Universite de Montreal, Departments of Medicine and Biochemistry, Universite de Montreal, 1560 rue Sherbrooke Est, Montreal, QC H2L 4M1, Canada
    Mol Neurodegener 7:54. 2012
  3. doi Misfolded SOD1 and ALS: zeroing in on mitochondria
    Sarah Pickles
    Centre d excellence en neuromique de l Université de Montréal, Centre de Recherche du CHUM CRCHUM, Montreal, QC, Canada
    Amyotroph Lateral Scler 13:333-40. 2012
  4. pmc Endo-MitoEGFP mice: a novel transgenic mouse with fluorescently marked mitochondria in microvascular endothelial cells
    Sarah Pickles
    Centre d excellence en neuromique de l Université de Montréal, Centre de recherche du Centre hospitalier de l Université de Montréal CRCHUM, Universite de Montreal, Montreal, Quebec, Canada Department of Biochemistry, Universite de Montreal, Montreal, Quebec, Canada
    PLoS ONE 8:e74603. 2013
  5. doi TAR DNA-binding protein 43 (TDP-43) regulates stress granule dynamics via differential regulation of G3BP and TIA-1
    Karli K McDonald
    Centre d excellence en neuromique de l Université de Montréal, Centre de Recherche du CHUM, Montreal, QC, Canada
    Hum Mol Genet 20:1400-10. 2011
  6. pmc Glucose delays age-dependent proteotoxicity
    Arnaud Tauffenberger
    CRCHUM, Universite de Montreal, Montreal, Quebec, Canada
    Aging Cell 11:856-66. 2012
  7. doi Gain and loss of function of ALS-related mutations of TARDBP (TDP-43) cause motor deficits in vivo
    Edor Kabashi
    Centre of Excellence in Neuromics, Department of Medicine, Universite de Montre al, Montreal, Quebec, Canada
    Hum Mol Genet 19:671-83. 2010
  8. pmc Requirement of NOX2 and reactive oxygen species for efficient RIG-I-mediated antiviral response through regulation of MAVS expression
    Anton Soucy-Faulkner
    CRCHUM Centre Hospitalier de l Université de Montréal, Montreal, Quebec, Canada
    PLoS Pathog 6:e1000930. 2010
  9. doi TARDBP mutations in individuals with sporadic and familial amyotrophic lateral sclerosis
    Edor Kabashi
    Center of Excellence in Neuromics, Centre Hospitalier de l Universite de Montreal, and Department of Medicine, University of Montreal, Montreal, Quebec H2L4MI, Canada
    Nat Genet 40:572-4. 2008

Collaborators

Detail Information

Publications10

  1. pmc Misfolded SOD1 associated with motor neuron mitochondria alters mitochondrial shape and distribution prior to clinical onset
    Christine Vande Velde
    Centre d excellence en neuromique de l Université de Montréal, and Département de Médecine, Universite de Montreal, Montreal, Quebec, Canada
    PLoS ONE 6:e22031. 2011
    ..These data indicate that mutant SOD1 binding to mitochondria disrupts normal mitochondrial distribution and size homeostasis as early pathogenic features of SOD1 mutant-mediated ALS...
  2. pmc Endogenous TDP-43, but not FUS, contributes to stress granule assembly via G3BP
    Anaïs Aulas
    Centre d excellence en neuromique de l Université de Montréal, Centre de recherche du Centre Hospitalier de l Universite de Montreal, Departments of Medicine and Biochemistry, Universite de Montreal, 1560 rue Sherbrooke Est, Montreal, QC H2L 4M1, Canada
    Mol Neurodegener 7:54. 2012
    ..These data raise the possibility that disruptions of normal stress granule dynamics by loss of nuclear TDP-43 function may contribute to neuronal vulnerability in ALS...
  3. doi Misfolded SOD1 and ALS: zeroing in on mitochondria
    Sarah Pickles
    Centre d excellence en neuromique de l Université de Montréal, Centre de Recherche du CHUM CRCHUM, Montreal, QC, Canada
    Amyotroph Lateral Scler 13:333-40. 2012
    ..We will review these new tools and expand on the evidence demonstrating mitochondria as a common intersecting point for misfolded SOD1...
  4. pmc Endo-MitoEGFP mice: a novel transgenic mouse with fluorescently marked mitochondria in microvascular endothelial cells
    Sarah Pickles
    Centre d excellence en neuromique de l Université de Montréal, Centre de recherche du Centre hospitalier de l Université de Montréal CRCHUM, Universite de Montreal, Montreal, Quebec, Canada Department of Biochemistry, Universite de Montreal, Montreal, Quebec, Canada
    PLoS ONE 8:e74603. 2013
    ..These transgenic mice will be useful to studies of ECs in development, physiology, and pathology. ..
  5. doi TAR DNA-binding protein 43 (TDP-43) regulates stress granule dynamics via differential regulation of G3BP and TIA-1
    Karli K McDonald
    Centre d excellence en neuromique de l Université de Montréal, Centre de Recherche du CHUM, Montreal, QC, Canada
    Hum Mol Genet 20:1400-10. 2011
    ..Thus, mutations in TDP-43 are mechanistically divergent. Finally, the cellular function of TDP-43 extends beyond splicing and places TDP-43 as a participant of the central cellular response to stress and an active player in RNA storage...
  6. pmc Glucose delays age-dependent proteotoxicity
    Arnaud Tauffenberger
    CRCHUM, Universite de Montreal, Montreal, Quebec, Canada
    Aging Cell 11:856-66. 2012
    ..Dysregulated metabolism is common to neurodegeneration and we show that glucose enrichment is broadly protective against proteotoxicity...
  7. doi Gain and loss of function of ALS-related mutations of TARDBP (TDP-43) cause motor deficits in vivo
    Edor Kabashi
    Centre of Excellence in Neuromics, Department of Medicine, Universite de Montre al, Montreal, Quebec, Canada
    Hum Mol Genet 19:671-83. 2010
    ....
  8. pmc Requirement of NOX2 and reactive oxygen species for efficient RIG-I-mediated antiviral response through regulation of MAVS expression
    Anton Soucy-Faulkner
    CRCHUM Centre Hospitalier de l Université de Montréal, Montreal, Quebec, Canada
    PLoS Pathog 6:e1000930. 2010
    ..Taken together these data reveal a new facet to the regulation of the innate host defense against viruses through the identification of an unrecognized role of NOX2 and ROS...
  9. doi TARDBP mutations in individuals with sporadic and familial amyotrophic lateral sclerosis
    Edor Kabashi
    Center of Excellence in Neuromics, Centre Hospitalier de l Universite de Montreal, and Department of Medicine, University of Montreal, Montreal, Quebec H2L4MI, Canada
    Nat Genet 40:572-4. 2008
    ..These findings further corroborate that TDP-43 is involved in ALS pathogenesis...