Min Zhuo


Affiliation: University of Toronto
Country: Canada


  1. Qiu S, Zhang M, Liu Y, Guo Y, Zhao H, Song Q, et al. GluA1 phosphorylation contributes to postsynaptic amplification of neuropathic pain in the insular cortex. J Neurosci. 2014;34:13505-15 pubmed publisher
  2. Song Q, Zheng H, Li X, Huganir R, Kuner T, Zhuo M, et al. Selective Phosphorylation of AMPA Receptor Contributes to the Network of Long-Term Potentiation in the Anterior Cingulate Cortex. J Neurosci. 2017;37:8534-8548 pubmed publisher
  3. Lu J, Chen Q, Zhou S, Wu F, Liu R, Zhou Z, et al. Contagious itch can be induced in humans but not in rodents. Mol Brain. 2019;12:38 pubmed publisher
    ..Finally, in healthy subjects, we found that viewing human itch video did cause itch sensation or responses. Our results indicate that the mouse model may not appropriate for studying contagious itch in humans. ..
  4. Lu J, Chen Q, Zhou S, Inokuchi K, Zhuo M. Dual roles of anterior cingulate cortex neurons in pain and pleasure in adult mice. Mol Brain. 2018;11:72 pubmed publisher
    ..Our findings suggest that ACC neurons play important roles in the process of both pain and pleasure. ..
  5. Zhuo M. Long-term cortical synaptic changes contribute to chronic pain and emotional disorders. Neurosci Lett. 2018;: pubmed publisher
    ..In this short review article, I will summarize recent progress using animal models and explore possible different mechanisms that may contribute to chronic pain in the brain. ..
  6. Zhuo M. Cortical LTP: A Synaptic Model for Chronic Pain. Adv Exp Med Biol. 2018;1099:147-155 pubmed publisher
    ..In this chapter, I will summarize our work on ACC and IC and provide evidence for calcium-stimulated AC1 as a key molecule for cortical LTP and chronic pain. ..
  7. Qiu S, Wu Y, Lv X, Li X, Zhuo M, Koga K. Reduced synaptic function of Kainate receptors in the insular cortex of Fmr1 Knock-out mice. Mol Brain. 2018;11:54 pubmed publisher
    ..Our studies provide evidence indicating that loss of FMRP leads to the abnormal function and localization of KARs. This finding implies a new molecular mechanism for Fragile X syndrome. ..
  8. Li X, Miao H, Zhuo M. NMDA Receptor Dependent Long-term Potentiation in Chronic Pain. Neurochem Res. 2019;44:531-538 pubmed publisher
    ..Investigation of signalling mechanisms for NMDAR LTP may provide novel targets for future treatment of chronic pain. ..
  9. request reprint
    Zhuo M. Targeting injury-related synaptic plasticity for the treatment of chronic pain. Curr Pharm Des. 2015;21:914-9 pubmed

More Information


  1. Koga K, Liu M, Qiu S, Song Q, O Den G, Chen T, et al. Impaired presynaptic long-term potentiation in the anterior cingulate cortex of Fmr1 knock-out mice. J Neurosci. 2015;35:2033-43 pubmed publisher
    ..Our results demonstrate that FMRP plays an important role in pre-LTP in the adult mouse ACC, and loss of this pre-LTP may explain some of the behavioral deficits in Fmr1 KO mice. ..
  2. Song Q, Liu M, Zhuo M. Minocycline does not affect long-term potentiation in the anterior cingulate cortex of normal adult mice. Mol Pain. 2015;11:25 pubmed publisher
    ..Our results suggest that minocycline does not affect cingulate plasticity and neurons are the major player in pain-related cortical plasticity. ..
  3. Liu M, Zhuo M. Loss of long-term depression in the insular cortex after tail amputation in adult mice. Mol Pain. 2014;10:1 pubmed publisher
  4. Chen T, O Den G, Song Q, Koga K, Zhang M, Zhuo M. Adenylyl cyclase subtype 1 is essential for late-phase long term potentiation and spatial propagation of synaptic responses in the anterior cingulate cortex of adult mice. Mol Pain. 2014;10:65 pubmed publisher
    ..It also provides basic mechanisms for possible side effects of gabapentin in the central nervous system and its ineffectiveness in some patients with neuropathic pain. ..
  5. Darvish Ghane S, Yamanaka M, Zhuo M. Dopaminergic Modulation of Excitatory Transmission in the Anterior Cingulate Cortex of Adult Mice. Mol Pain. 2016;12: pubmed publisher
    ..Our finding posits a pre- and postsynaptic mode of pyramidal neuron EPSC modulation in mice ACC by DA. ..
  6. Ko H, Choi J, Park D, Kang S, Lim C, Sim S, et al. Rapid Turnover of Cortical NCAM1 Regulates Synaptic Reorganization after Peripheral Nerve Injury. Cell Rep. 2018;22:748-759 pubmed publisher
    ..Our results, therefore, demonstrate a synaptic mechanism for cortical reorganization and suggest potential avenues for neuropathic pain treatment. ..
  7. Yamanaka M, Tian Z, Darvish Ghane S, Zhuo M. Pre-LTP requires extracellular signal-regulated kinase in the ACC. Mol Pain. 2016;12: pubmed publisher
  8. Zhuo M. Ionotropic glutamate receptors contribute to pain transmission and chronic pain. Neuropharmacology. 2017;112:228-234 pubmed publisher
    ..This article is part of the Special Issue entitled 'Ionotropic glutamate receptors'. ..
  9. Koga K, Li S, Zhuo M. Metabotropic Glutamate Receptor Dependent Cortical Plasticity in Chronic Pain. Curr Neuropharmacol. 2016;14:427-34 pubmed
    ..We propose that targeting mGluRs in the cortical areas including the ACC and IC may provide a new therapeutic strategy for the treatment of chronic pain, phantom pain or anxiety. ..
  10. Kang S, Kwak C, Lee J, Sim S, Shim J, Choi T, et al. Bidirectional modulation of hyperalgesia via the specific control of excitatory and inhibitory neuronal activity in the ACC. Mol Brain. 2015;8:81 pubmed publisher
    ..Our results provide direct evidence of the pivotal role of ACC excitatory neurons, and their regulation by PV expressing interneurons, in nociception. ..
  11. Li X, Wang N, Wang Y, Zuo Z, Koga K, Luo F, et al. Long-term temporal imprecision of information coding in the anterior cingulate cortex of mice with peripheral inflammation or nerve injury. J Neurosci. 2014;34:10675-87 pubmed publisher
  12. Koga K, Yao I, Setou M, Zhuo M. SCRAPPER Selectively Contributes to Spontaneous Release and Presynaptic Long-Term Potentiation in the Anterior Cingulate Cortex. J Neurosci. 2017;37:3887-3895 pubmed publisher
    ..Our recent study found that a presynaptic form of LTP (pre-LTP) in the ACC contributes to chronic pain-induced anxiety. Here, we show that SCRAPPER plays a critical role in ACC pre-LTP as well as synaptic transmission. ..
  13. Zhuo M. Cortical kainate receptors and behavioral anxiety. Mol Brain. 2017;10:16 pubmed publisher
  14. Tian Z, Yamanaka M, Bernabucci M, Zhao M, Zhuo M. Characterization of serotonin-induced inhibition of excitatory synaptic transmission in the anterior cingulate cortex. Mol Brain. 2017;10:21 pubmed publisher
    ..Our results strongly suggest that presynaptic as well as postsynaptic 5-HT receptor including 5-HT1A subtype receptor may contribute to inhibitory modulation of glutamate release as well as postsynaptic responses in the ACC. ..
  15. Zhuo M. Plasticity of NMDA receptor NR2B subunit in memory and chronic pain. Mol Brain. 2009;2:4 pubmed publisher
    ..A positive feedback control of NR2B receptor subunit is proposed to explain cortical sensitization involved in chronic pain, but not learning and memory. ..
  16. Li X, Song Q, Chen Q, Lu J, Chen T, Zhuo M. Characterization of excitatory synaptic transmission in the anterior cingulate cortex of adult tree shrew. Mol Brain. 2017;10:58 pubmed publisher
    ..Our studies provide the first report of the basal synaptic transmission in the ACC of adult tree shrew. ..
  17. Liu S, Zhang M, Cheng L, Shi J, Lu J, Zhuo M. Long-term upregulation of cortical glutamatergic AMPA receptors in a mouse model of chronic visceral pain. Mol Brain. 2015;8:76 pubmed publisher
    ..Our results provide direct evidence for cortical AMPA receptors to contribute to zymosan-induced visceral and spontaneous pain and inhibition of AC1 activity may help to reduce chronic visceral pain. ..
  18. Kang S, Liu M, Shi T, Zhao M, Kaang B, Zhuo M. N-type voltage gated calcium channels mediate excitatory synaptic transmission in the anterior cingulate cortex of adult mice. Mol Pain. 2013;9:58 pubmed publisher
    ..Our results provide strong evidence that N-type VGCCs mediate fast synaptic transmission in the ACC. ..
  19. Cao X, Mercaldo V, Li P, Wu L, Zhuo M. Facilitation of the inhibitory transmission by gastrin-releasing peptide in the anterior cingulate cortex. Mol Pain. 2010;6:52 pubmed publisher
    ..Our results suggest that GRP receptor is an important regulator of inhibitory circuits in forebrain areas. ..