Ryan Zarychanski

Summary

Affiliation: University of Manitoba
Country: Canada

Publications

  1. pmc Hemoglobin levels and transfusions in neurocritically ill patients: a systematic review of comparative studies
    Philippe Desjardins
    Department of Anesthesiology, Division of Critical Care Medicine, Faculty of Medicine, Universite Laval, 1050, Avenue de Médecine, Pavillon Ferdinand Vandry, Quebec, QC, G1V 0A6, Canada
    Crit Care 16:R54. 2012
  2. doi request reprint Association of hydroxyethyl starch administration with mortality and acute kidney injury in critically ill patients requiring volume resuscitation: a systematic review and meta-analysis
    Ryan Zarychanski
    University of Manitoba, Department of Internal Medicine, Section of Critical Care, University of Manitoba, ON2056 675 McDermot Ave, Winnipeg, Manitoba R3E 0V9, Canada
    JAMA 309:678-88. 2013
  3. pmc Correlates of severe disease in patients with 2009 pandemic influenza (H1N1) virus infection
    Ryan Zarychanski
    Department of Internal Medicine, University of Manitoba, CancerCare Manitoba, Winnipeg, Manitoba
    CMAJ 182:257-64. 2010
  4. pmc Enteric absorption and pharmacokinetics of oseltamivir in critically ill patients with pandemic (H1N1) influenza
    Robert E Ariano
    Department of Pharmacy, St Boniface General Hospital, and Department of Internal Medicine, The Faculty of Pharmacy, University of Manitoba, Winnipeg, Manitoba
    CMAJ 182:357-63. 2010
  5. ncbi request reprint Perinatal and maternal outcomes in critically ill obstetrics patients with pandemic H1N1 Influenza A
    Titilayo Oluyomi-Obi
    Department of Obstetrics, Gynaecology and Reproductive Sciences, University of Manitoba, Winnipeg MB, Canada
    J Obstet Gynaecol Can 32:443-7, 448-52. 2010
  6. doi request reprint Extracorporeal lung support for patients who had severe respiratory failure secondary to influenza A (H1N1) 2009 infection in Canada
    Darren H Freed
    Surgical Heart Failure Program, Cardiac Sciences Program, St Boniface General Hospital, CR3030 Asper Clinical Research Building, 369 Tache Ave, Winnipeg, Manitoba R2H 2A6, Canada
    Can J Anaesth 57:240-7. 2010
  7. doi request reprint Sedation and analgesia usage in severe pandemic H1N1 (2009) infection: a comparison to respiratory failure secondary to other infectious pneumonias
    Kendiss Olafson
    Section of Critical Care, Department of Medicine, University of Manitoba, Winnipeg, MB, Canada
    Ann Pharmacother 46:9-20. 2012
  8. doi request reprint Acute kidney injury in critically ill patients infected with 2009 pandemic influenza A(H1N1): report from a Canadian Province
    Manish M Sood
    St Boniface General Hospital, University of Manitoba, Winnipeg, Manitoba, Canada
    Am J Kidney Dis 55:848-55. 2010
  9. doi request reprint Preoperative anemia does not increase the risks of early surgical revascularization after myocardial infarction
    Li Zhang
    Cardiac Sciences Program, St Boniface Hospital I H Asper Clinical Research Institute, Winnipeg, Manitoba, Canada
    Ann Thorac Surg 95:542-7. 2013
  10. doi request reprint Historical perspectives in critical care medicine: blood transfusion, intravenous fluids, inotropes/vasopressors, and antibiotics
    Ryan Zarychanski
    Section of Critical Care Medicine, University of Manitoba, JJ399 700 William Avenue, Winnipeg, Manitoba, Canada
    Crit Care Clin 25:201-20, x. 2009

Collaborators

Detail Information

Publications16

  1. pmc Hemoglobin levels and transfusions in neurocritically ill patients: a systematic review of comparative studies
    Philippe Desjardins
    Department of Anesthesiology, Division of Critical Care Medicine, Faculty of Medicine, Universite Laval, 1050, Avenue de Médecine, Pavillon Ferdinand Vandry, Quebec, QC, G1V 0A6, Canada
    Crit Care 16:R54. 2012
    ..Accumulating evidence suggests that, in critically ill patients, a lower hemoglobin transfusion threshold is safe. However, the optimal hemoglobin level and associated transfusion threshold remain unknown in neurocritically ill patients...
  2. doi request reprint Association of hydroxyethyl starch administration with mortality and acute kidney injury in critically ill patients requiring volume resuscitation: a systematic review and meta-analysis
    Ryan Zarychanski
    University of Manitoba, Department of Internal Medicine, Section of Critical Care, University of Manitoba, ON2056 675 McDermot Ave, Winnipeg, Manitoba R3E 0V9, Canada
    JAMA 309:678-88. 2013
    ..Clinical trials of hydroxyethyl starch are conflicting. Moreover, multiple trials from one investigator have been retracted because of scientific misconduct...
  3. pmc Correlates of severe disease in patients with 2009 pandemic influenza (H1N1) virus infection
    Ryan Zarychanski
    Department of Internal Medicine, University of Manitoba, CancerCare Manitoba, Winnipeg, Manitoba
    CMAJ 182:257-64. 2010
    ..The objective of this study was to identify factors correlated with severity of disease in confirmed cases of pandemic H1N1 influenza...
  4. pmc Enteric absorption and pharmacokinetics of oseltamivir in critically ill patients with pandemic (H1N1) influenza
    Robert E Ariano
    Department of Pharmacy, St Boniface General Hospital, and Department of Internal Medicine, The Faculty of Pharmacy, University of Manitoba, Winnipeg, Manitoba
    CMAJ 182:357-63. 2010
    ..We documented the pharmacokinetic profile of oseltamivir in patients admitted to intensive care units (ICUs) with suspected or confirmed pandemic (H1N1) influenza...
  5. ncbi request reprint Perinatal and maternal outcomes in critically ill obstetrics patients with pandemic H1N1 Influenza A
    Titilayo Oluyomi-Obi
    Department of Obstetrics, Gynaecology and Reproductive Sciences, University of Manitoba, Winnipeg MB, Canada
    J Obstet Gynaecol Can 32:443-7, 448-52. 2010
    ..Information about these cases will be useful to help us understand the potential impact of future outbreaks and review critical illness in pregnancy...
  6. doi request reprint Extracorporeal lung support for patients who had severe respiratory failure secondary to influenza A (H1N1) 2009 infection in Canada
    Darren H Freed
    Surgical Heart Failure Program, Cardiac Sciences Program, St Boniface General Hospital, CR3030 Asper Clinical Research Building, 369 Tache Ave, Winnipeg, Manitoba R2H 2A6, Canada
    Can J Anaesth 57:240-7. 2010
    ..In this report, we describe characteristics, treatment, and outcomes of critically ill patients in Canada who had H1N1-2009 infection and were treated with extracorporeal lung support (ECLS)...
  7. doi request reprint Sedation and analgesia usage in severe pandemic H1N1 (2009) infection: a comparison to respiratory failure secondary to other infectious pneumonias
    Kendiss Olafson
    Section of Critical Care, Department of Medicine, University of Manitoba, Winnipeg, MB, Canada
    Ann Pharmacother 46:9-20. 2012
    ..During the 2009 H1N1 pandemic (pH1N1), patients requiring mechanical ventilation for respiratory failure received high doses of sedation and analgesia...
  8. doi request reprint Acute kidney injury in critically ill patients infected with 2009 pandemic influenza A(H1N1): report from a Canadian Province
    Manish M Sood
    St Boniface General Hospital, University of Manitoba, Winnipeg, Manitoba, Canada
    Am J Kidney Dis 55:848-55. 2010
    ..2009 pandemic influenza A(H1N1) has led to a global increase in severe respiratory illness. Little is known about kidney outcomes and dialytic requirements in critically ill patients infected with pandemic H1N1...
  9. doi request reprint Preoperative anemia does not increase the risks of early surgical revascularization after myocardial infarction
    Li Zhang
    Cardiac Sciences Program, St Boniface Hospital I H Asper Clinical Research Institute, Winnipeg, Manitoba, Canada
    Ann Thorac Surg 95:542-7. 2013
    ..The objective of this study was to investigate the impact of preoperative anemia on short-term outcomes after coronary bypass surgery in patients with a recent MI...
  10. doi request reprint Historical perspectives in critical care medicine: blood transfusion, intravenous fluids, inotropes/vasopressors, and antibiotics
    Ryan Zarychanski
    Section of Critical Care Medicine, University of Manitoba, JJ399 700 William Avenue, Winnipeg, Manitoba, Canada
    Crit Care Clin 25:201-20, x. 2009
    ..Prominent medical and social pressures that have catalyzed research and innovation in each domain are also addressed, as well as current and future challenges...
  11. doi request reprint Activated protein C and septic shock: a propensity-matched cohort study*
    Emily Rimmer
    Department of Internal Medicine, University of Manitoba, Winnipeg, Canada
    Crit Care Med 40:2974-81. 2012
    ..Further clinical trials, including a recently completed trial in patients with septic shock, failed to reproduce these results...
  12. doi request reprint Early combination antibiotic therapy yields improved survival compared with monotherapy in septic shock: a propensity-matched analysis
    Anand Kumar
    Section of Critical Care Medicine, Health Sciences Centre St Boniface Hospital, University of Manitoba, Winnipeg, Manitoba, Canada
    Crit Care Med 38:1773-85. 2010
    ..Current guidelines do not recommend combination therapy except for the express purpose of broadening coverage when resistant pathogens are a concern...
  13. doi request reprint Early intravenous unfractionated heparin and mortality in septic shock
    Ryan Zarychanski
    Section of Critical Care Medicine, University of Manitoba, Winnipeg, Manitoba, Canada
    Crit Care Med 36:2973-9. 2008
    ..Unfractionated heparin is a known anticoagulant, which also possesses anti-inflammatory properties. Unfractionated heparin has been shown to increase survival in experimental models of septic shock...
  14. pmc Mutations in the mechanotransduction protein PIEZO1 are associated with hereditary xerocytosis
    Ryan Zarychanski
    CancerCare Manitoba, Department of Hematology and Medical Oncology, Winnipeg, MB
    Blood 120:1908-15. 2012
    ..These findings, the first report of mutation in a mammalian mechanosensory transduction channel-associated with genetic disease, suggest that PIEZO proteins play an important role in maintaining erythrocyte volume homeostasis...
  15. doi request reprint Impact of 24-hour in-house intensivists on a dedicated cardiac surgery intensive care unit
    Kanwal Kumar
    Cardiovascular Health Research in Manitoba Investigator Group, Cardiac Sciences Program, St Boniface General Hospital IH Asper Clinical Research Institute, Winnipeg, Manitoba, Canada
    Ann Thorac Surg 88:1153-61. 2009
    ..Clinical outcomes associated with 24-hour, in-house intensivists working in a dedicated post-cardiac surgical unit has not been previously investigated. We sought to examine the safety and efficacy of such a model...
  16. pmc Anemia of chronic disease: a harmful disorder or an adaptive, beneficial response?
    Ryan Zarychanski
    Section of Hematology Medical Oncology, Department of Internal Medicine, University of Manitoba, Winnipeg, Man
    CMAJ 179:333-7. 2008