Affiliation: University of Manitoba
- Hemoglobin levels and transfusions in neurocritically ill patients: a systematic review of comparative studiesPhilippe Desjardins
Department of Anesthesiology, Division of Critical Care Medicine, Faculty of Medicine, Universite Laval, 1050, Avenue de Médecine, Pavillon Ferdinand Vandry, Quebec, QC, G1V 0A6, Canada
Crit Care 16:R54. 2012..Accumulating evidence suggests that, in critically ill patients, a lower hemoglobin transfusion threshold is safe. However, the optimal hemoglobin level and associated transfusion threshold remain unknown in neurocritically ill patients...
- Association of hydroxyethyl starch administration with mortality and acute kidney injury in critically ill patients requiring volume resuscitation: a systematic review and meta-analysisRyan Zarychanski
University of Manitoba, Department of Internal Medicine, Section of Critical Care, University of Manitoba, ON2056 675 McDermot Ave, Winnipeg, Manitoba R3E 0V9, Canada
JAMA 309:678-88. 2013..Clinical trials of hydroxyethyl starch are conflicting. Moreover, multiple trials from one investigator have been retracted because of scientific misconduct...
- Correlates of severe disease in patients with 2009 pandemic influenza (H1N1) virus infectionRyan Zarychanski
Department of Internal Medicine, University of Manitoba, CancerCare Manitoba, Winnipeg, Manitoba
CMAJ 182:257-64. 2010..The objective of this study was to identify factors correlated with severity of disease in confirmed cases of pandemic H1N1 influenza...
- Enteric absorption and pharmacokinetics of oseltamivir in critically ill patients with pandemic (H1N1) influenzaRobert E Ariano
Department of Pharmacy, St Boniface General Hospital, and Department of Internal Medicine, The Faculty of Pharmacy, University of Manitoba, Winnipeg, Manitoba
CMAJ 182:357-63. 2010..We documented the pharmacokinetic profile of oseltamivir in patients admitted to intensive care units (ICUs) with suspected or confirmed pandemic (H1N1) influenza...
- Perinatal and maternal outcomes in critically ill obstetrics patients with pandemic H1N1 Influenza ATitilayo Oluyomi-Obi
Department of Obstetrics, Gynaecology and Reproductive Sciences, University of Manitoba, Winnipeg MB, Canada
J Obstet Gynaecol Can 32:443-7, 448-52. 2010..Information about these cases will be useful to help us understand the potential impact of future outbreaks and review critical illness in pregnancy...
- Extracorporeal lung support for patients who had severe respiratory failure secondary to influenza A (H1N1) 2009 infection in CanadaDarren H Freed
Surgical Heart Failure Program, Cardiac Sciences Program, St Boniface General Hospital, CR3030 Asper Clinical Research Building, 369 Tache Ave, Winnipeg, Manitoba R2H 2A6, Canada
Can J Anaesth 57:240-7. 2010..In this report, we describe characteristics, treatment, and outcomes of critically ill patients in Canada who had H1N1-2009 infection and were treated with extracorporeal lung support (ECLS)...
- Sedation and analgesia usage in severe pandemic H1N1 (2009) infection: a comparison to respiratory failure secondary to other infectious pneumoniasKendiss Olafson
Section of Critical Care, Department of Medicine, University of Manitoba, Winnipeg, MB, Canada
Ann Pharmacother 46:9-20. 2012..During the 2009 H1N1 pandemic (pH1N1), patients requiring mechanical ventilation for respiratory failure received high doses of sedation and analgesia...
- Acute kidney injury in critically ill patients infected with 2009 pandemic influenza A(H1N1): report from a Canadian ProvinceManish M Sood
St Boniface General Hospital, University of Manitoba, Winnipeg, Manitoba, Canada
Am J Kidney Dis 55:848-55. 2010..2009 pandemic influenza A(H1N1) has led to a global increase in severe respiratory illness. Little is known about kidney outcomes and dialytic requirements in critically ill patients infected with pandemic H1N1...
- Preoperative anemia does not increase the risks of early surgical revascularization after myocardial infarctionLi Zhang
Cardiac Sciences Program, St Boniface Hospital I H Asper Clinical Research Institute, Winnipeg, Manitoba, Canada
Ann Thorac Surg 95:542-7. 2013..The objective of this study was to investigate the impact of preoperative anemia on short-term outcomes after coronary bypass surgery in patients with a recent MI...
- Historical perspectives in critical care medicine: blood transfusion, intravenous fluids, inotropes/vasopressors, and antibioticsRyan Zarychanski
Section of Critical Care Medicine, University of Manitoba, JJ399 700 William Avenue, Winnipeg, Manitoba, Canada
Crit Care Clin 25:201-20, x. 2009..Prominent medical and social pressures that have catalyzed research and innovation in each domain are also addressed, as well as current and future challenges...
- Activated protein C and septic shock: a propensity-matched cohort study*Emily Rimmer
Department of Internal Medicine, University of Manitoba, Winnipeg, Canada
Crit Care Med 40:2974-81. 2012..Further clinical trials, including a recently completed trial in patients with septic shock, failed to reproduce these results...
- Early combination antibiotic therapy yields improved survival compared with monotherapy in septic shock: a propensity-matched analysisAnand Kumar
Section of Critical Care Medicine, Health Sciences Centre St Boniface Hospital, University of Manitoba, Winnipeg, Manitoba, Canada
Crit Care Med 38:1773-85. 2010..Current guidelines do not recommend combination therapy except for the express purpose of broadening coverage when resistant pathogens are a concern...
- Early intravenous unfractionated heparin and mortality in septic shockRyan Zarychanski
Section of Critical Care Medicine, University of Manitoba, Winnipeg, Manitoba, Canada
Crit Care Med 36:2973-9. 2008..Unfractionated heparin is a known anticoagulant, which also possesses anti-inflammatory properties. Unfractionated heparin has been shown to increase survival in experimental models of septic shock...
- Mutations in the mechanotransduction protein PIEZO1 are associated with hereditary xerocytosisRyan Zarychanski
CancerCare Manitoba, Department of Hematology and Medical Oncology, Winnipeg, MB
Blood 120:1908-15. 2012..These findings, the first report of mutation in a mammalian mechanosensory transduction channel-associated with genetic disease, suggest that PIEZO proteins play an important role in maintaining erythrocyte volume homeostasis...
- Impact of 24-hour in-house intensivists on a dedicated cardiac surgery intensive care unitKanwal Kumar
Cardiovascular Health Research in Manitoba Investigator Group, Cardiac Sciences Program, St Boniface General Hospital IH Asper Clinical Research Institute, Winnipeg, Manitoba, Canada
Ann Thorac Surg 88:1153-61. 2009..Clinical outcomes associated with 24-hour, in-house intensivists working in a dedicated post-cardiac surgical unit has not been previously investigated. We sought to examine the safety and efficacy of such a model...
- Anemia of chronic disease: a harmful disorder or an adaptive, beneficial response?Ryan Zarychanski
Section of Hematology Medical Oncology, Department of Internal Medicine, University of Manitoba, Winnipeg, Man
CMAJ 179:333-7. 2008