G W Zamponi

Summary

Affiliation: University of Calgary
Country: Canada

Publications

  1. pmc Specific T-type calcium channel isoforms are associated with distinct burst phenotypes in deep cerebellar nuclear neurons
    Michael L Molineux
    Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada T2N 4N1
    Proc Natl Acad Sci U S A 103:5555-60. 2006
  2. pmc Prion protein attenuates excitotoxicity by inhibiting NMDA receptors
    Houman Khosravani
    Department of Physiology and Biophysics, Hotchkiss Brain Institute, University of Calgary, Calgary T2N4N1, Canada
    J Cell Biol 181:551-65. 2008
  3. pmc Activity-dependent subcellular cotrafficking of the small GTPase Rem2 and Ca2+/CaM-dependent protein kinase IIα
    Robyn Flynn
    Department of Physiology and Pharmacology, Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada
    PLoS ONE 7:e41185. 2012
  4. pmc Low voltage activation of KCa1.1 current by Cav3-KCa1.1 complexes
    Renata Rehak
    Department of Physiology and Pharmacology, Hotchkiss Brain Institute, University of Calgary, Calgary, Canada
    PLoS ONE 8:e61844. 2013
  5. pmc Mercury-induced toxicity of rat cortical neurons is mediated through N-Methyl-D-Aspartate receptors
    Fenglian Xu
    Department of Cell Biology and Anatomy, University of Calgary, Alberta, Canada
    Mol Brain 5:30. 2012
  6. pmc Analgesic effect of a mixed T-type channel inhibitor/CB2 receptor agonist
    Vinicius M Gadotti
    Department of Physiology and Pharmacology, Hotchkiss Brain Institute, University of Calgary, Calgary, Canada
    Mol Pain 9:32. 2013
  7. doi request reprint Common mechanisms of drug interactions with sodium and T-type calcium channels
    Chris Bladen
    Department of Physiology and Pharmacology, Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada
    Mol Pharmacol 82:481-7. 2012
  8. pmc The Brugada syndrome mutation A39V does not affect surface expression of neuronal rat Cav1.2 channels
    Brett A Simms
    Department of Physiology and Pharmacology, Hotchkiss Brain Institute, University of Calgary, Calgary, Canada
    Mol Brain 5:9. 2012
  9. pmc Copper-dependent regulation of NMDA receptors by cellular prion protein: implications for neurodegenerative disorders
    Peter K Stys
    Department of Clinical Neurosciences, Hotchkiss Brain Institute, University of Calgary, Calgary, Canada
    J Physiol 590:1357-68. 2012
  10. pmc Cellular prion protein protects from inflammatory and neuropathic pain
    Vinicius M Gadotti
    Department of Physiology and Pharmacology, Hotchkiss Brain Institute, University of Calgary, Calgary T2N 4N1, Canada
    Mol Pain 7:59. 2011

Collaborators

Detail Information

Publications96

  1. pmc Specific T-type calcium channel isoforms are associated with distinct burst phenotypes in deep cerebellar nuclear neurons
    Michael L Molineux
    Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada T2N 4N1
    Proc Natl Acad Sci U S A 103:5555-60. 2006
    ..The Ca(v)3 class of LVA calcium channels is thus expressed in specific combinations in a wide range of cerebellar neurons but contributes to rebound burst discharge in only a select number of cell classes...
  2. pmc Prion protein attenuates excitotoxicity by inhibiting NMDA receptors
    Houman Khosravani
    Department of Physiology and Biophysics, Hotchkiss Brain Institute, University of Calgary, Calgary T2N4N1, Canada
    J Cell Biol 181:551-65. 2008
    ..Thus, native PrP(C) mediates an important neuroprotective role by virtue of its ability to inhibit NR2D subunits...
  3. pmc Activity-dependent subcellular cotrafficking of the small GTPase Rem2 and Ca2+/CaM-dependent protein kinase IIα
    Robyn Flynn
    Department of Physiology and Pharmacology, Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada
    PLoS ONE 7:e41185. 2012
    ..Rem2 is the only RGK protein found predominantly in the brain, where it has been linked to synaptic development. We wished to determine the effect of neuronal activity on the subcellular distribution of Rem2 and its interacting partners...
  4. pmc Low voltage activation of KCa1.1 current by Cav3-KCa1.1 complexes
    Renata Rehak
    Department of Physiology and Pharmacology, Hotchkiss Brain Institute, University of Calgary, Calgary, Canada
    PLoS ONE 8:e61844. 2013
    ..1 activation over a wide range of membrane potentials according to the unique voltage profile of Cav3 calcium channels, greatly extending the roles for KCa1.1 potassium channels in controlling membrane excitability...
  5. pmc Mercury-induced toxicity of rat cortical neurons is mediated through N-Methyl-D-Aspartate receptors
    Fenglian Xu
    Department of Cell Biology and Anatomy, University of Calgary, Alberta, Canada
    Mol Brain 5:30. 2012
    ..Here, we examine the effects of various mercury concentrations (including pathological levels present in human plasma or cerebrospinal fluid) on cultured, rat cortical neurons...
  6. pmc Analgesic effect of a mixed T-type channel inhibitor/CB2 receptor agonist
    Vinicius M Gadotti
    Department of Physiology and Pharmacology, Hotchkiss Brain Institute, University of Calgary, Calgary, Canada
    Mol Pain 9:32. 2013
    ..Cannabinoid receptors and T-type calcium channels are potential targets for treating pain. Here we report on the design, synthesis and analgesic properties of a new mixed cannabinoid/T-type channel ligand, NMP-181...
  7. doi request reprint Common mechanisms of drug interactions with sodium and T-type calcium channels
    Chris Bladen
    Department of Physiology and Pharmacology, Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada
    Mol Pharmacol 82:481-7. 2012
    ....
  8. pmc The Brugada syndrome mutation A39V does not affect surface expression of neuronal rat Cav1.2 channels
    Brett A Simms
    Department of Physiology and Pharmacology, Hotchkiss Brain Institute, University of Calgary, Calgary, Canada
    Mol Brain 5:9. 2012
    ..2 (A39V) has been shown to elicit disease a phenotype because of a loss of surface trafficking of the channel. This lack of cell membrane expression could not be rescued by the trafficking chaperone Cavβ...
  9. pmc Copper-dependent regulation of NMDA receptors by cellular prion protein: implications for neurodegenerative disorders
    Peter K Stys
    Department of Clinical Neurosciences, Hotchkiss Brain Institute, University of Calgary, Calgary, Canada
    J Physiol 590:1357-68. 2012
    ....
  10. pmc Cellular prion protein protects from inflammatory and neuropathic pain
    Vinicius M Gadotti
    Department of Physiology and Pharmacology, Hotchkiss Brain Institute, University of Calgary, Calgary T2N 4N1, Canada
    Mol Pain 7:59. 2011
    ..Altogether, our data indicate that PrPC exerts a critical role in modulating nociceptive transmission at the spinal cord level, and fit with the concept of NMDA receptor hyperfunction in the absence of PrPC...
  11. pmc Scanning mutagenesis of the I-II loop of the Cav2.2 calcium channel identifies residues Arginine 376 and Valine 416 as molecular determinants of voltage dependent G protein inhibition
    Hugo W Tedford
    Department of Physiology and Pharmacology, Hotchkiss Brain Institute, University of Calgary, Canada
    Mol Brain 3:6. 2010
    ....
  12. pmc Role of prions in neuroprotection and neurodegeneration: a mechanism involving glutamate receptors?
    Gerald W Zamponi
    Department of Physiology and Pharmacology, Hotchkiss Brain Institute, University of Calgary, Cal, CA
    Prion 3:187-9. 2009
    ..Such is a functional link between NMDA receptors and normal prion protein, and therefore possibly between these receptors and pathological prion isoforms, raises interesting therapeutic possibilities for prion diseases...
  13. pmc Functional characterization and analgesic effects of mixed cannabinoid receptor/T-type channel ligands
    Haitao You
    Department of Physiology and Pharmacology, Hotchkiss Brain Institute, University of Calgary, Calgary, Canada
    Mol Pain 7:89. 2011
    ..Here, we investigate the analgesics activities of a series of novel cannabinoid receptor ligands with T-type calcium channel blocking activity...
  14. pmc Role of voltage-gated calcium channels in ascending pain pathways
    Gerald W Zamponi
    Department of Physiology and Biophysics, Hotchkiss Brain Institute, University of Calgary, 3330 Hospital Drive NW, Calgary, Canada T2N 4N1
    Brain Res Rev 60:84-9. 2009
    ..Here, we provide a brief overview of recent advances in this area, as presented at the Spring Pain Research conference (Grand Cayman, 2008)...
  15. ncbi request reprint Regulation of presynaptic calcium channels by synaptic proteins
    Gerald W Zamponi
    Department of Physiology and Biophysics, Cellular and Molecular Neurobiology, Research Group, University of Calgary, Calgary T2N 4N1, Canada
    J Pharmacol Sci 92:79-83. 2003
    ..This does not occur with invertebrate synaptic calcium channel homologs, suggesting that the regulation of calcium channel activity by synaptic proteins is a mechanism unique to vertebrates...
  16. ncbi request reprint Modulating modulation: crosstalk between regulatory pathways of presynaptic calcium channels
    Gerald W Zamponi
    Department of Physiology and Biophysics, University of Calgary, Canada
    Mol Interv 2:476-8. 2002
    ..Wu et al. stress that because PIP2 can be found at synapses, PIP2-dependent control of VGCCs "could have profound consequences on synaptic transmission and plasticity."..
  17. pmc The L-type calcium channel C-terminus: sparking interest beyond its role in calcium-dependent inactivation
    Gerald W Zamponi
    Department of Physiology and Biophysics, Cellular and Molecular Neurobiology Research Group, University of Calgary, Calgary T2N 4N1, Canada
    J Physiol 552:333. 2003
  18. ncbi request reprint Determinants of G protein inhibition of presynaptic calcium channels
    G W Zamponi
    Department of Physiology and Biophysics, University of Calgary, Canada
    Cell Biochem Biophys 34:79-94. 2001
    ..Thus, the regulation of the activities of presynaptic Ca channels is becoming increasingly complex, a feature that may contribute to the overall fine-tuning of Ca entry into presynaptic nerve termini, and thus, neurotransmission...
  19. pmc Open-channel block by internally applied amines inhibits activation gate closure in batrachotoxin-activated sodium channels
    G W Zamponi
    Department of Medical Physiology, University of Calgary, Calgary, Alberta, Canada
    Biophys J 67:1040-51. 1994
    ..Such a mechanism might underlie the previously reported immobilization of gating charge associated with local anesthetic block of unmodified sodium channels...
  20. ncbi request reprint Residue Gly1326 of the N-type calcium channel alpha 1B subunit controls reversibility of omega-conotoxin GVIA and MVIIA block
    Z P Feng
    Departments of Physiology and Biophysics and Pharmacology and Therapeutics, Neuroscience Research Group, University of Calgary, Calgary, Alberta T2N 4N1, Canada
    J Biol Chem 276:15728-35. 2001
    ....
  21. pmc Transcainide causes two modes of open-channel block with different voltage sensitivities in batrachotoxin-activated sodium channels
    G W Zamponi
    Department of Medical Physiology, University of Calgary, Alberta, Canada
    Biophys J 67:1028-39. 1994
    ..Dose-response relations were also consistent with independent binding of transcainide to two separate sites on the channel...
  22. ncbi request reprint Distinct molecular determinants govern syntaxin 1A-mediated inactivation and G-protein inhibition of N-type calcium channels
    S E Jarvis
    Department of Physiology and Biophysics, Neuroscience and Smooth Muscle Research Groups, University of Calgary, Calgary, T2N 4N1, Canada
    J Neurosci 21:2939-48. 2001
    ..Thus, separate molecular determinants govern the ability of syntaxin 1A to affect N-type channel gating and its modulation by G-proteins...
  23. pmc Fast lidocaine block of cardiac and skeletal muscle sodium channels: one site with two routes of access
    G W Zamponi
    Department of Medical Physiology, University of Calgary, Alberta, Canada
    Biophys J 65:80-90. 1993
    ....
  24. pmc State-dependent block underlies the tissue specificity of lidocaine action on batrachotoxin-activated cardiac sodium channels
    G W Zamponi
    Department of Medical Physiology, University of Calgary, Alberta, Canada
    Biophys J 65:91-100. 1993
    ..It is the slow block caused by lidocaine binding to this closed state that underlies the channel-subtype specificity of lidocaine action in our experiments...
  25. pmc Dual actions of procainamide on batrachotoxin-activated sodium channels: open channel block and prevention of inactivation
    G W Zamponi
    Department of Medical Physiology, University of Calgary, Alberta, Canada
    Biophys J 65:2324-34. 1993
    ..Internally applied QX-314, a lidocaine derivative and also a fast blocker, produced a similar effect. Thus, drug binding to the fast blocking site appears to inhibit inactivation in BTX-activated cardiac channels...
  26. ncbi request reprint Calcium channel beta subunits differentially regulate the inhibition of N-type channels by individual Gbeta isoforms
    Z P Feng
    Department of Physiology, University of Calgary, Calgary T2N 4N1, Canada
    J Biol Chem 276:45051-8. 2001
    ....
  27. ncbi request reprint Temperature dependence of T-type calcium channel gating
    M Iftinca
    Department of Physiology and Biophysics, University of Calgary, 3330 Hospital Drive Northwest, Calgary, Canada T2N 4N1
    Neuroscience 142:1031-42. 2006
    ..3, but not rat Ca(v)3.3. The observed changes in the kinetics were significant but not identical for the three isoforms, showing that the ability of T-type channels to conduct calcium varies with both channel isoform and temperature...
  28. ncbi request reprint Determinants of the differential gating properties of Cav3.1 and Cav3.3 T-type channels: a role of domain IV?
    J Hamid
    Hotchkiss Brain Institute and Department of Physiology and Biophysics, University of Calgary, 3330 Hospital Drive Northwest, Calgary, Canada T2N 4N1
    Neuroscience 143:717-28. 2006
    ..Our data indicate that the domain IV region mediates an important role in T-type channel activation, whereas multiple channel structural determinants appear to control T-type channel inactivation...
  29. ncbi request reprint Sodium current inhibition by internal calcium: a combination of open-channel block and surface charge screening?
    G W Zamponi
    Department of Medical Physiology, University of Calgary, Canada
    J Membr Biol 147:1-6. 1995
    ..Hence, our data support the view that sodium current inhibition by internal calcium arises from a combination of both open-channel block and surface charge effects...
  30. pmc Amine blockers of the cytoplasmic mouth of sodium channels: a small structural change can abolish voltage dependence
    G W Zamponi
    Department of Medical Physiology, University of Calgary, Alberta, Canada
    Biophys J 67:1015-27. 1994
    ..If so, our data place limits on the distance between this receptor and the intrapore site at which charged amines bind...
  31. ncbi request reprint Identification of inactivation determinants in the domain IIS6 region of high voltage-activated calcium channels
    S C Stotz
    Department of Physiology and Biophysics, Neuroscience and Smooth Muscle Research Groups, University of Calgary, Calgary, Alberta T2N 4N1, Canada
    J Biol Chem 276:33001-10. 2001
    ..Overall, our results provide novel insights into a complex process underlying calcium channel inactivation...
  32. ncbi request reprint Structural determinants of fast inactivation of high voltage-activated Ca(2+) channels
    S C Stotz
    Dept of Physiology and Biophysics, Neuroscience Research Group, University of Calgary, Canada T2N 4N1
    Trends Neurosci 24:176-81. 2001
    ..However, the latest findings suggest a mechanism in which fast Ca(2+) channel inactivation could occur through physical occlusion of the pore of the channel in a manner reminiscent of Na(+) and K(+) channel inactivation...
  33. ncbi request reprint Modulation of voltage-dependent calcium channels by G proteins
    G W Zamponi
    Department of Pharmacology and Therapeutics, University of Calgary, Canada
    Curr Opin Neurobiol 8:351-6. 1998
    ..Recent advances have provided important clues to the underlying molecular mechanisms involved in the inhibition of N-type and P/Q-type calcium channels by a membrane-delimited G-protein-dependent pathway...
  34. ncbi request reprint Interactions between presynaptic Ca2+ channels, cytoplasmic messengers and proteins of the synaptic vesicle release complex
    S E Jarvis
    Dept. of Physiology and Biophysics, University of Calgary, 3330 Hospital Drive NW, T2N 4N1, Calgary, Canada
    Trends Pharmacol Sci 22:519-25. 2001
    ....
  35. ncbi request reprint Interactions between a pore-blocking peptide and the voltage sensor of the sodium channel: an electrostatic approach to channel geometry
    R J French
    Department of Medical Physiology, Faculty of Medicine, University of Calgary, Alberta, Canada
    Neuron 16:407-13. 1996
    ..We show that this activation shift could result entirely from electrostatic inhibition of the movement of the voltage-sensing S4 charges and estimate the approximate physical distance through which the S4 charges move...
  36. ncbi request reprint Inhibition of transiently expressed low- and high-voltage-activated calcium channels by trivalent metal cations
    A M Beedle
    Department of Physiology and Biophysics, University of Calgary, 3330 Hospital Dr NW, Calgary, Canada
    J Membr Biol 187:225-38. 2002
    ....
  37. pmc Protease-activated receptor-4: a novel mechanism of inflammatory pain modulation
    S Asfaha
    Mucosal Inflammation Research Group, Department of Pharmacology and Therapeutics, University of Calgary, Calgary, Alberta, Canada
    Br J Pharmacol 150:176-85. 2007
    ..CONCLUSIONS AND IMPLICATIONS: Taken together, these results identified PAR(4) as a novel potential endogenous analgesic factor, which can modulate nociceptive responses in normal and inflammatory conditions...
  38. ncbi request reprint Molecular and kinetic determinants of local anaesthetic action on sodium channels
    R J French
    Department of Physiology and Biophysics, The University of Calgary, Alberta, Canada
    Toxicol Lett 100:247-54. 1998
    ..5) Site-directed mutagenesis studies suggest that hydrophobic residues in transmembrane segment 6 of repeat domain 4 of sodium channels are critical for both LA binding and stabilization of the inactivated state...
  39. pmc Differential modulation of N-type 1B and P/Q-type 1A calcium channels by different G protein subunit isoforms
    M I Arnot
    Neuroscience and Smooth Muscle Research Groups, Department of Pharmacology and Therapeutics, University of Calgary, Calgary, Canada
    J Physiol 527:203-12. 2000
    ..The differential modulation of P/Q- and N-type channels by various Gbeta subtypes may provide a mechanism for fine tuning the amount of calcium entering the presynaptic nerve termini...
  40. pmc Cav1.4 encodes a calcium channel with low open probability and unitary conductance
    Clinton J Doering
    Hotchkiss Brain Institute, Department of Physiology and Biophysics, Faculty of Medicine, University of Calgary, 3330 Hospital Drive NW, Calgary, Alberta T2N 4N1, Canada
    Biophys J 89:3042-8. 2005
    ..4 channels support only minute amounts of calcium entry, suggesting that large numbers of these channels are needed to allow for significant whole-cell current activity, and providing a mechanism to reduce noise in the visual system...
  41. ncbi request reprint The Arg473Cys-neuroligin-1 mutation modulates NMDA mediated synaptic transmission and receptor distribution in hippocampal neurons
    Houman Khosravani
    Department of Physiology and Biophysics, Hotchkiss Brain Institute, University of Calgary, HMRB 182b, 3330 Hospital Dr NW Calgary, Alta, Canada T2N 4N1
    FEBS Lett 579:6587-94. 2005
    ..We demonstrate that R473C-NL1, when expressed in cultured hippocampal neurons, can induce a dramatic increase in NMDA current amplitude and that this change is accompanied by NMDA receptor clustering in the postsynaptic cell...
  42. pmc Functional roles of cytoplasmic loops and pore lining transmembrane helices in the voltage-dependent inactivation of HVA calcium channels
    Stephanie C Stotz
    Department of Physiology and Biophysics, University of Calgary, 3330 Hospital Drive NW, Calgary T2N 4N1, Canada
    J Physiol 554:263-73. 2004
    ....
  43. ncbi request reprint Calcium channel structural determinants of synaptic transmission between identified invertebrate neurons
    J David Spafford
    Department of Molecular and Cellular Neurobiology, Vrije Universiteit, Amsterdam, 108HV Netherlands
    J Biol Chem 278:4258-67. 2003
    ....
  44. ncbi request reprint Presynaptic Ca2+ channels--integration centers for neuronal signaling pathways
    Rhian M Evans
    Hotchkiss Brain Institute, Department of Physiology and Biophysics, Faculty of Medicine, University of Calgary, Calgary, Alberta T2N 4N1, Canada
    Trends Neurosci 29:617-24. 2006
    ..Here, we provide a broad overview of molecular and cellular mechanisms that regulate Ca2+ channels, and how these cellular signaling pathways are integrated at the level of the channel protein...
  45. ncbi request reprint Molecular determinants of cysteine string protein modulation of N-type calcium channels
    Linda C Miller
    Neuroscience Research Group, Department of Physiology and Biophysics, University of Calgary, Calgary, Alberta, T2N 4N1, Canada
    J Cell Sci 116:2967-74. 2003
    ..These results suggest that distinct binding sites of CSP can play a role in modulating G protein function and G protein inhibition of calcium channels...
  46. ncbi request reprint Direct G protein modulation of Cav2 calcium channels
    H William Tedford
    Hotchkiss Brain Institute, Department of Physiology and Biophysics, University of Calgary, Calgary, Canada
    Pharmacol Rev 58:837-62. 2006
    ..Twenty-five years after this mode of physiological regulation was first described, we review the investigations that have led to our current understanding of its molecular mechanisms...
  47. ncbi request reprint Calcium-triggered membrane fusion proceeds independently of specific presynaptic proteins
    Joseph A Szule
    Department of Physiology and Biophysics, Cellular and Molecular Neurobiology Research Group, University of Calgary, Health Sciences Centre, Faculty of Medicine, Alberta T2N 4N1, Canada
    J Biol Chem 278:24251-4. 2003
    ..SNAREs, synaptotagmin, and their immediate binding partners are critical to exocytosis at a stage other than membrane fusion, although they may still influence the triggered steps...
  48. doi request reprint Molecular determinants of Rem2 regulation of N-type calcium channels
    Robyn Flynn
    Department of Physiology and Biophysics, Hotchkiss Brain Institute, University of Calgary, 3330 Hospital Dr NW, Calgary AB, Canada T2N 4N1
    Biochem Biophys Res Commun 368:827-31. 2008
    ..Co-precipitation assays showed that Ca(v) beta(3) interaction depends on Rem2 residues 1-123. Only Rem2 proteins that targeted the cell membrane as well as bound the beta subunit were able to reduce whole cell calcium currents...
  49. ncbi request reprint Expression and modulation of an invertebrate presynaptic calcium channel alpha1 subunit homolog
    J David Spafford
    Department of Physiology and Biophysics, Cellular and Molecular Neurobiology Research Group, University of Calgary, Calgary, T2N 4N1, Canada
    J Biol Chem 278:21178-87. 2003
    ....
  50. doi request reprint D1 receptors physically interact with N-type calcium channels to regulate channel distribution and dendritic calcium entry
    Alexandra E Kisilevsky
    Department of Physiology and Biophysics, Hotchkiss Brain Institute, University of Calgary, 3330 Hospital Drive Northwest, Calgary, Canada
    Neuron 58:557-70. 2008
    ..Our data indicate that the N-type calcium channel is an important physiological target of D1 receptors and reveal a mechanism for D1 receptor-mediated regulation of cognitive function in the PFC...
  51. pmc Differential interactions of Na+ channel toxins with T-type Ca2+ channels
    Hui Sun
    Excigen, Inc, Baltimore, MD 21224, USA
    J Gen Physiol 132:101-13. 2008
    ....
  52. ncbi request reprint Synthesis and evaluation of a new class of nifedipine analogs with T-type calcium channel blocking activity
    P Phani Kumar
    Vittal Mallya Scientific Research Foundation, Bangalore, India
    Mol Pharmacol 61:649-58. 2002
    ..Thus, dialkyl 1,4-dihydro-4-(2'alkoxy-6'-pentadecylphenyl)-2,6-dimethyl-3,5 pyridine dicarboxylates may serve as excellent candidates for the development of T-type calcium-channel specific blockers...
  53. ncbi request reprint Molecular pharmacology of non-L-type calcium channels
    Clinton J Doering
    Cellular and Molecular Neurobiology Research Group, Department of Physiology and Biophysics, University of Calgary, 3330 Hospital Dr NW, Calgary, T2N 4N1, Canada
    Curr Pharm Des 11:1887-98. 2005
    ..Here, we provide an overview of classes of inhibitors of non-L-type calcium channels...
  54. ncbi request reprint Masters or slaves? Vesicle release machinery and the regulation of presynaptic calcium channels
    Scott E Jarvis
    Department of Physiology and Biophysics, Hotchkiss Brain Institute, University of Calgary, 3330 Hospital Dr NW, Calgary, Canada T2N 4N1
    Cell Calcium 37:483-8. 2005
    ..Hence, presynaptic calcium channels act not only as the masters of the synaptic release process, but also as key targets for feedback inhibition...
  55. ncbi request reprint Calmodulin lobotomized: novel insights into calcium regulation of voltage-gated calcium channels
    Gerald W Zamponi
    Department of Physiology and Biophysics, Cellular and Molecular Neurobiology Research Group, University of Calgary, Calgary T2N 4N1, Canada
    Neuron 39:879-81. 2003
  56. ncbi request reprint Auxiliary subunit regulation of high-voltage activated calcium channels expressed in mammalian cells
    Takahiro Yasuda
    Department of Physiology and Biophysics, Cellular and Molecular Neurobiology Research Group, University of Calgary, 3330 Hospital Dr NW, Calgary, T2N 4 N1, Canada
    Eur J Neurosci 20:1-13. 2004
    ..Moreover, the effects of each auxiliary subunit on whole cell conductance and channel gating appear to be specifically tailored to subsets of calcium channel subtypes...
  57. ncbi request reprint Gating effects of mutations in the Cav3.2 T-type calcium channel associated with childhood absence epilepsy
    Houman Khosravani
    Cellular and Molecular Neurobiology Research Group, University of Calgary, Canada
    J Biol Chem 279:9681-4. 2004
    ..This may underlie the propensity for seizures in patients with CAE...
  58. ncbi request reprint The alpha2delta auxiliary subunit reduces affinity of omega-conotoxins for recombinant N-type (Cav2.2) calcium channels
    Jorgen Mould
    Institute for Molecular Bioscience, University of Queensland, Queensland 4072, Australia
    J Biol Chem 279:34705-14. 2004
    ..These results may have implications for the antinociceptive properties of omega-conotoxins, given that the alpha(2)delta subunit is up-regulated in certain pain states...
  59. ncbi request reprint Molecular pharmacology of high voltage-activated calcium channels
    Clinton J Doering
    Department of Physiology and Biophysics, University of Calgary, 3330 Hospital Dr NW, Calgary, Canada T2N 4N1
    J Bioenerg Biomembr 35:491-505. 2003
    ..Here, we provide a comprehensive review of pharmacology of high voltage-activated calcium channels...
  60. ncbi request reprint The CACNA1F gene encodes an L-type calcium channel with unique biophysical properties and tissue distribution
    John E McRory
    Biotechnology Laboratory, University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z3
    J Neurosci 24:1707-18. 2004
    ..Immunohistochemical analyses show that, in contrast with previous reports, Ca(v)1.4 is widely distributed outside the retina, including in the immune system, thus suggesting a broader role in human physiology...
  61. ncbi request reprint Several structural domains contribute to the regulation of N-type calcium channel inactivation by the beta 3 subunit
    Stephanie C Stotz
    Department of Physiology and Biophysics Cellular and Molecular Neurobiology Research Group, University of Calgary, Calgary, Alberta T2N 4N1, Canada
    J Biol Chem 279:3793-800. 2004
    ..2 did not alter the regulation of the channel by wild type and chimeric beta subunits. Hence, the molecular underpinnings of beta subunit regulation of voltage-gated calcium channels appear to vary with calcium channel subtype...
  62. ncbi request reprint Cysteine string protein (CSP) inhibition of N-type calcium channels is blocked by mutant huntingtin
    Linda C Miller
    Cellular and Molecular Neurobiology Research Group, Department of Physiology and Biophysics, University of Calgary, Calgary, Alberta T2N 4N1, Canada
    J Biol Chem 278:53072-81. 2003
    ..These results indicate that CSP's modulation of G protein inhibition of calcium channel activity is blocked in the presence of a huntingtin fragment with expanded polyglutamine tracts...
  63. ncbi request reprint Voltage-gated sodium and calcium channels in nerve, muscle, and heart
    Robert J French
    Department of Physiology and Biophysics, University of Calgary, Calgary, AB T2N 4N1, Canada
    IEEE Trans Nanobioscience 4:58-69. 2005
    ..Crucial to these advances are studies of bacterial homologues of ion channels from man and other eukaryotes, and the use of naturally occurring peptide toxins which target different ion channel types with exquisite specificity...
  64. ncbi request reprint Depolarization-induced Ca2+ release in ischemic spinal cord white matter involves L-type Ca2+ channel activation of ryanodine receptors
    Mohamed Ouardouz
    Ottawa Health Research Institute, Division of Neuroscience, University of Ottawa, Ottawa, Ontario K1Y 4K9, Canada
    Neuron 40:53-63. 2003
    ....
  65. ncbi request reprint Scanning mutagenesis of omega-atracotoxin-Hv1a reveals a spatially restricted epitope that confers selective activity against insect calcium channels
    Hugo W Tedford
    Department of Molecular, Microbial, and Structural Biology, University of Connecticut Health Center, Farmington 06032 3305, USA
    J Biol Chem 279:44133-40. 2004
    ..This epitope provides a structural template for rational design of chemical insecticides that selectively target insect Cav channels...
  66. ncbi request reprint Signaling complexes of voltage-gated calcium channels and G protein-coupled receptors
    Christophe Altier
    Hotchkiss Brain Institute, Department of Physiology and Biophysics, University of Calgary, Canada
    J Recept Signal Transduct Res 28:71-81. 2008
    ..Hence, interactions between receptors and voltage-gated calcium channels may be a widely applicable means to optimize receptor channel coupling...
  67. ncbi request reprint Agonist-independent modulation of N-type calcium channels by ORL1 receptors
    Aaron M Beedle
    Department of Physiology and Biophysics, Cellular and Molecular Neurobiology Research Group, University of Calgary, 3330 Hospital Drive NW, Calgary, Alberta T2N 4N1, Canada
    Nat Neurosci 7:118-25. 2004
    ..Calcium channel activity is thus regulated by changes in ORL1 receptor expression, which provides a possible molecular mechanism for the development of tolerance to opioid receptor agonists...
  68. pmc Novel splice variants of rat CaV2.1 that lack much of the synaptic protein interaction site are expressed in neuroendocrine cells
    W R A Kosala J S Rajapaksha
    Department of Physiology, College of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan S7N 5E5
    J Biol Chem 283:15997-6003. 2008
    ..These results have important implications for Ca(V)2.1 function and for the mechanisms of Ca(V)2.1 targeting in neurons and neuroendocrine cells...
  69. ncbi request reprint Expression of T-type calcium channel splice variants in human glioma
    Isabelle Latour
    Department of Physiology and Biophysics, Faculty of Medicine, University of Calgary, Calgary, Alberta T2N 4N1, Canada
    Glia 48:112-9. 2004
    ..1b, but a slower recovery from inactivation. Taken together, our data suggest glioma-specific Ca(v)3.1 gene regulation, which could possibly contribute to tumor pathogenesis...
  70. ncbi request reprint Determinants of inhibition of transiently expressed voltage-gated calcium channels by omega-conotoxins GVIA and MVIIA
    Zhong Ping Feng
    Department of Physiology and Biophysics, Cellular and Molecular Neurobiology Research Group, University of Calgary, Canada
    J Biol Chem 278:20171-8. 2003
    ..We propose a model in which N-type calcium channels can form both reversible and irreversible complexes with MVIIA...
  71. ncbi request reprint Expression of voltage-gated Ca2+ channel subtypes in cultured astrocytes
    Isabelle Latour
    Department of Physiology and Biophysics, Faculty of Medicine, University of Calgary, Calgary, Canada
    Glia 41:347-53. 2003
    ..Overall, our data indicate that astrocytes express multiple types of voltage-gated Ca(2+) channels, hinting at a complex regulation of Ca(2+) homeostasis in glial cells...
  72. ncbi request reprint Unique structure-activity relationship for 4-isoxazolyl-1,4-dihydropyridines
    Gerald W Zamponi
    Department of Pharmacology and Therapeutics, University of Calgary, 3330 Hospital Drive NW, Calgary, Alberta T2N 4N1, Canada
    J Med Chem 46:87-96. 2003
    ..A variable-temperature NMR study confirmed the computation. With Striessnig's computational sequence homologation procedure, a working hypothesis was derived from the data that explains the unique SAR for IDs...
  73. pmc Glycerotoxin from Glycera convoluta stimulates neurosecretion by up-regulating N-type Ca2+ channel activity
    Frederic A Meunier
    Molecular Neuropathobiology Laboratory, Cancer Research UK, London Research Institute, Lincoln s Inn Fields Laboratories, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
    EMBO J 21:6733-43. 2002
    ..Therefore, glycerotoxin is a unique addition to the arsenal of tools available to unravel the mechanism controlling Ca(2+)-regulated exocytosis via the specific activation of Ca(v)2.2...
  74. ncbi request reprint ORL1 receptor-mediated internalization of N-type calcium channels
    Christophe Altier
    Department of Physiology and Biophysics, Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta T2N 4N1, Canada
    Nat Neurosci 9:31-40. 2006
    ..This may provide a new means for long-term regulation of calcium entry in the pain pathway...
  75. ncbi request reprint Molecular determinants of syntaxin 1 modulation of N-type calcium channels
    Scott E Jarvis
    Department of Physiology, University of Calgary, Canada
    J Biol Chem 277:44399-407. 2002
    ..Finally, syntaxin 1A appeared to compete with Ggamma for the Gbeta subunit both in vitro and under physiological conditions, suggesting that syntaxin 1A may contain a G-protein gamma subunit-like domain...
  76. ncbi request reprint T-Type calcium channel alpha1G and alpha1H subunits in human retinoblastoma cells and their loss after differentiation
    Kazuyuki Hirooka
    Department of Physiology and Biophysics, Dalhousie University, Halifax, Nova Scotia B3H 4H7
    J Neurophysiol 88:196-205. 2002
    ....
  77. ncbi request reprint Identification and characterization of novel human Ca(v)2.2 (alpha 1B) calcium channel variants lacking the synaptic protein interaction site
    Shuji Kaneko
    Department of Neuropharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo ku, Kyoto 606 8501, Japan
    J Neurosci 22:82-92. 2002
    ..These results suggest that the structure of the II-III linker region is an important determinant of N-type channel function and pharmacology. The lack of syntaxin binding hints at a unique physiological function of these channels...
  78. ncbi request reprint Linking calcium-channel isoforms to potential therapies
    Francesco Belardetti
    Neuromed Pharmaceuticals, Vancouver, Canada
    Curr Opin Investig Drugs 9:707-15. 2008
    ..An overview of advances in the development of calcium-channel therapeutics in the areas of pain, epilepsy and disorders associated with cardiovascular function are discussed...
  79. doi request reprint Making the T-type even tinier: corticotropin-releasing factor-mediated inhibition of low-voltage-activated calcium channel activity
    Diego L Varela
    Hotchkiss Brain Institute, Department of Physiology and Biophysics, University of Calgary, Calgary, T2N 4N1, Canada
    Mol Pharmacol 73:1589-91. 2008
    ..In this issue of Molecular Pharmacology, Tao et al. (p. 1596) demonstrate that Cav3.2 is regulated by activation of the corticotropin-releasing factor receptor 1 in a Gbetagamma-dependent manner...
  80. ncbi request reprint Use 'em and lose 'em-activity-induced removal of calcium channels from the plasma membrane
    Diego Varela
    Hotchkiss Brain Institute, Department of Physiology and Biophysics, University of Calgary, Calgary, T2N 4N1, Canada
    Neuron 55:539-41. 2007
    ..In this issue of Neuron, Green and colleagues demonstrate that the opening of L-type calcium channels results in negative feedback regulation due to their calcium-dependent internalization...
  81. ncbi request reprint Voltage gated calcium channels as targets for analgesics
    Emmanuel Bourinet
    Departement de Physiologie, Institut de Génomique Fonctionnelle CNRS UMR5203, INSERM U661, Universités Montpellier I and II, 141 rue de la Cardonille, 34094 Montpellier Cedex 5, France
    Curr Top Med Chem 5:539-46. 2005
    ..Here, we review the role of these channels and their accessory subunits in nociceptive signaling, and their potential as targets for development of innovative analgesics...
  82. ncbi request reprint Crosstalk between huntingtin and syntaxin 1A regulates N-type calcium channels
    Leigh Anne Swayne
    Department of Physiology and Biophysics, Hotchkiss Brain Institute, The University of Calgary, Calgary, Alberta, Canada T2N 4N1
    Mol Cell Neurosci 30:339-51. 2005
    ..Our data indicate that htt(exon1) enhances calcium influx by blocking syntaxin 1A inhibition of N-type calcium channels and attributes a key role for htt N-terminal fragments in the fine tuning of neurotransmission...
  83. ncbi request reprint In vitro characterization of L-type calcium channels and their contribution to firing behavior in invertebrate respiratory neurons
    J David Spafford
    Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada
    J Neurophysiol 95:42-52. 2006
    ..Our data therefore suggest an important role of L-type calcium channels in maintaining rhythmical pattern activity underlying breathing behavior in Lymnaea...
  84. ncbi request reprint Targeting Ca2+ channels to treat pain: T-type versus N-type
    Christophe Altier
    Department of Physiology and Biophysics, Cellular and Molecular Neurobiology Research Group, University of Calgary, Calgary, Alberta T2N 4N1, Canada
    Trends Pharmacol Sci 25:465-70. 2004
    ..In this review, we discuss the implications of these findings for the design of novel therapeutic strategies and contrast the role of T-type channels with that of N-type channels in pain transmission and analgesia...
  85. ncbi request reprint Functional interactions between presynaptic calcium channels and the neurotransmitter release machinery
    J David Spafford
    Department of Physiology and Biophysics, Cellular and Molecular Neurobiology Research Group, University of Calgary, 3330 Hospital Drive, Northwest Calgary, T2N 4N1, Canada
    Curr Opin Neurobiol 13:308-14. 2003
    ..These studies require us to expand current models of synaptic transmission...
  86. ncbi request reprint Binding of protein phosphatase 2A to the L-type calcium channel Cav1.2 next to Ser1928, its main PKA site, is critical for Ser1928 dephosphorylation
    Duane D Hall
    Department of Pharmacology, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242 1109, USA
    Biochemistry 45:3448-59. 2006
    ..2 is required for effective reversal of PKA-mediated channel phosphorylation. Accordingly, PKA as well as PP2A are constitutively associated with Ca(v)1.2 for its proper regulation by phosphorylation and dephosphorylation of serine 1928...
  87. ncbi request reprint Functional analysis of Ca3.2 T-type calcium channel mutations linked to childhood absence epilepsy
    Jean B Peloquin
    Department of Physiology and Biophysics, Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta
    Epilepsia 47:655-8. 2006
    ..Childhood absence epilepsy (CAE) is an idiopathic form of seizure disorder that is believed to have a genetic basis...
  88. ncbi request reprint Integrin receptor activation triggers converging regulation of Cav1.2 calcium channels by c-Src and protein kinase A pathways
    Peichun Gui
    Department of Medical Pharmacology and Physiology, University of Missouri School of Medicine, Columbia, Missouri 65212, USA
    J Biol Chem 281:14015-25. 2006
    ..These findings are consistent with the growing recognition of the importance of integrin-channel interactions in cellular responses to injury and the acute control of synaptic and blood vessel function...
  89. ncbi request reprint Role of angiotensin II type 1A receptor phosphorylation, phospholipase D, and extracellular calcium in isoform-specific protein kinase C membrane translocation responses
    Aleksandra Policha
    Cell Biology Research Group, Robarts Research Institute, Department of Physiology and Pharmacology, The University of Western Ontario, 100 Perth Drive, London, Ontario N6A 5K8, Canada
    J Biol Chem 281:26340-9. 2006
    ..Taken together, we show that the patterning of AT(1A)R second messenger response patterns is regulated by heterologous desensitization and PKC isoform substrate specificity...
  90. ncbi request reprint Role of the synprint site in presynaptic targeting of the calcium channel CaV2.2 in hippocampal neurons
    Zsolt Szabo
    Department of Physiology and Medical Physics, Innsbruck Medical University, Fritz Pregl Str 3, A 6020 Innsbruck, Austria
    Eur J Neurosci 24:709-18. 2006
    ..The unique targeting properties of the splice variants lacking the synprint site are suggestive of specific functions of these calcium channels apart from activating fast synaptic transmission...
  91. ncbi request reprint Uncoupling of calcium channel alpha1 and beta subunits in developing neurons
    J David Spafford
    Cellular and Molecular Neurobiology Research Group, University of Calgary, Calgary T2N 4N1, Canada
    J Biol Chem 279:41157-67. 2004
    ....
  92. pmc Protease-activated receptor 2 sensitizes the transient receptor potential vanilloid 4 ion channel to cause mechanical hyperalgesia in mice
    Andrew D Grant
    Department of Surgery, UCSF, 513 Parnassus Ave, Room S1268, San Francisco, CA 94143 0660, USA
    J Physiol 578:715-33. 2007
    ....
  93. ncbi request reprint Selective inhibition of Cav3.3 T-type calcium channels by Galphaq/11-coupled muscarinic acetylcholine receptors
    Michael E Hildebrand
    Michael Smith Laboratories, University of British Columbia, Vancouver, British Columbia V6T 1Z4
    J Biol Chem 282:21043-55. 2007
    ..3 channel are necessary and sufficient for complete M1 receptor-mediated channel inhibition and represent novel sites not previously implicated in T-type channel modulation...
  94. ncbi request reprint Regulation of T-type calcium channels by Rho-associated kinase
    Mircea Iftinca
    Hotchkiss Brain Institute, Department of Physiology and Biophysics, University of Calgary, 3330 Hospital Drive N W, Calgary, T2N 4N1, Canada
    Nat Neurosci 10:854-60. 2007
    ..2 current in dorsal root ganglion neurons. Our data suggest that ROCK is an important regulator of T-type calcium channels, with potentially far-reaching implications for multiple cell functions modulated by LPA...
  95. ncbi request reprint Trafficking and regulation of neuronal voltage-gated calcium channels
    Scott E Jarvis
    Hotchkiss Brain Institute, Department of Physiology and Biophysics, University of Calgary, 3330 Hospital Dr NW, Calgary T2N 4N1, Canada
    Curr Opin Cell Biol 19:474-82. 2007
    ..Here we highlight recent advances in our understanding of these fundamentally important mechanisms...
  96. ncbi request reprint Topiramate inhibits the initiation of plateau potentials in CA1 neurons by depressing R-type calcium channels
    Joseph Brent Kuzmiski
    Brain Research Centre, Department of Psychiatry, University of British Columbia, Vancouver, British Columbia, Canada
    Epilepsia 46:481-9. 2005
    ..Cholinergic-dependent plateau potentials (PPs) are intrinsically generated conductances that can elicit ictal-type seizure activity. The aim of this study was to investigate the actions of topiramate (TPM) on the generation of PPs...