Peter H Yu

Summary

Affiliation: University of Saskatchewan
Country: Canada

Publications

  1. ncbi request reprint Increase of formation of methylamine and formaldehyde in vivo after administration of nicotine and the potential cytotoxicity
    P H Yu
    Department of Psychiatry, University of Saskatchewan, Saskatoon, Canada
    Neurochem Res 23:1205-10. 1998
  2. ncbi request reprint Physiological and pathological implications of semicarbazide-sensitive amine oxidase
    Peter H Yu
    Neuropsychiatry Research Unit, Department of Psychiatry, College of Medicine, University of Saskatchewan, A114 Medical Research Building, Saskatoon, Saskatchewan, Canada S7N 5E4
    Biochim Biophys Acta 1647:193-9. 2003
  3. ncbi request reprint Involvement of cerebrovascular semicarbazide-sensitive amine oxidase in the pathogenesis of Alzheimer's disease and vascular dementia
    P H Yu
    Neuropsychiatry Research Unit, Department of Psychiatry, College of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada
    Med Hypotheses 57:175-9. 2001
  4. ncbi request reprint 2-Bromoethylamine as a potent selective suicide inhibitor for semicarbazide-sensitive amine oxidase
    P H Yu
    Neuropsychiatry Research Unit, Department of Psychiatry, University of Saskatchewan, Saskatoon, S7N 5E4, Saskatchewan, Canada
    Biochem Pharmacol 61:741-8. 2001
  5. ncbi request reprint Brasofensine NeuroSearch
    P Yu
    Neuropsychiatric Research Unit, Department of Psychiatry, A114 Medical Research Building, University of Saskatchewan, Saskatoon, Saskatchewan, CA S7N 0WO, Canada
    Curr Opin Investig Drugs 1:504-7. 2000
  6. ncbi request reprint Potential cytotoxic effect of chronic administration of creatine, a nutrition supplement to augment athletic performance
    P H Yu
    Neuropsychiatry Research Unit, University of Saskatchewan, Saskatoon, Saskatchewan, Canada
    Med Hypotheses 54:726-8. 2000
  7. ncbi request reprint Effect of the Hypericum perforatum extract on serotonin turnover in the mouse brain
    P H Yu
    Department of Psychiatry, University of Saskatchewan, Saskatoon, Canada
    Pharmacopsychiatry 33:60-5. 2000
  8. ncbi request reprint Inversion of selectivity of N-substituted propargylamine monoamine oxidase inhibitors following structural modifications to quaternary salts
    P H Yu
    Department of Psychiatry, University of Saskatchewan, Saskatoon, Canada
    Int J Biochem Cell Biol 31:1391-7. 1999
  9. ncbi request reprint Endogenous formaldehyde as a potential factor of vulnerability of atherosclerosis: involvement of semicarbazide-sensitive amine oxidase-mediated methylamine turnover
    P H Yu
    Department of Psychiatry, University of Saskatchewan, Saskatoon, Canada
    Atherosclerosis 140:357-63. 1998
  10. ncbi request reprint A novel HPLC procedure for detection and quantification of aminoacetone, a precursor of methylglyoxal, in biological samples
    Michael Kazachkov
    Neuropsychiatry Research Unit, Department of Psychiatry, University of Saskatchewan, A114 Medical Research Building, 103 Wiggins Road, Saskatoon, Sask, Canada
    J Chromatogr B Analyt Technol Biomed Life Sci 824:116-22. 2005

Collaborators

Detail Information

Publications18

  1. ncbi request reprint Increase of formation of methylamine and formaldehyde in vivo after administration of nicotine and the potential cytotoxicity
    P H Yu
    Department of Psychiatry, University of Saskatchewan, Saskatoon, Canada
    Neurochem Res 23:1205-10. 1998
    ..The findings support the idea that nicotine can enhance SSAO/methylamine-mediated increase of formaldehyde and oxidative stress and this could in part contribute the adverse effect of health associated with smoking...
  2. ncbi request reprint Physiological and pathological implications of semicarbazide-sensitive amine oxidase
    Peter H Yu
    Neuropsychiatry Research Unit, Department of Psychiatry, College of Medicine, University of Saskatchewan, A114 Medical Research Building, Saskatoon, Saskatchewan, Canada S7N 5E4
    Biochim Biophys Acta 1647:193-9. 2003
    ..It suggests that SSAO is involved in vascular disorders under certain pathological conditions. Although SSAO has been known for several decades, its physiological and pathological implications are just beginning to be recognized...
  3. ncbi request reprint Involvement of cerebrovascular semicarbazide-sensitive amine oxidase in the pathogenesis of Alzheimer's disease and vascular dementia
    P H Yu
    Neuropsychiatry Research Unit, Department of Psychiatry, College of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada
    Med Hypotheses 57:175-9. 2001
    ..Formaldehyde may cause cytotoxicity, which induces inflammation and release of more SSAO, producing a cascade of toxic cycle. Increased SSAO-mediated reaction may be chronically involved in the pathogenesis of vascular dementia and AD...
  4. ncbi request reprint 2-Bromoethylamine as a potent selective suicide inhibitor for semicarbazide-sensitive amine oxidase
    P H Yu
    Neuropsychiatry Research Unit, Department of Psychiatry, University of Saskatchewan, Saskatoon, S7N 5E4, Saskatchewan, Canada
    Biochem Pharmacol 61:741-8. 2001
    ..It increased the urinary excretion of methylamine, an endogenous substrate for SSAO, in mice. 2-BrEA can be employed as a very useful tool in the investigation of SSAO...
  5. ncbi request reprint Brasofensine NeuroSearch
    P Yu
    Neuropsychiatric Research Unit, Department of Psychiatry, A114 Medical Research Building, University of Saskatchewan, Saskatoon, Saskatchewan, CA S7N 0WO, Canada
    Curr Opin Investig Drugs 1:504-7. 2000
    ..The analysts predicted peak sales would occur in 2009, with sales of $250 million at that time [319225]...
  6. ncbi request reprint Potential cytotoxic effect of chronic administration of creatine, a nutrition supplement to augment athletic performance
    P H Yu
    Neuropsychiatry Research Unit, University of Saskatchewan, Saskatoon, Saskatchewan, Canada
    Med Hypotheses 54:726-8. 2000
    ..Chronic administration of a large quantity of creatine can increase the production of formaldehyde, which may potentially cause serious unwanted side-effects...
  7. ncbi request reprint Effect of the Hypericum perforatum extract on serotonin turnover in the mouse brain
    P H Yu
    Department of Psychiatry, University of Saskatchewan, Saskatoon, Canada
    Pharmacopsychiatry 33:60-5. 2000
    ..The effect of Hypericum extract on the brain 5-HIAA and 5-FIT levels appeared to be quite different from the effect of classical 5-HT re-uptake blockers...
  8. ncbi request reprint Inversion of selectivity of N-substituted propargylamine monoamine oxidase inhibitors following structural modifications to quaternary salts
    P H Yu
    Department of Psychiatry, University of Saskatchewan, Saskatoon, Canada
    Int J Biochem Cell Biol 31:1391-7. 1999
    ..The results also suggest that at least three sites are required for the selectivity and mechanism-based action of an inhibitor towards MAO...
  9. ncbi request reprint Endogenous formaldehyde as a potential factor of vulnerability of atherosclerosis: involvement of semicarbazide-sensitive amine oxidase-mediated methylamine turnover
    P H Yu
    Department of Psychiatry, University of Saskatchewan, Saskatoon, Canada
    Atherosclerosis 140:357-63. 1998
    ..The increase of production of formaldehyde, possibly other aldehydes, may induce endothelial injury or be chronically involved in protein cross-linking and subsequent angiopathy...
  10. ncbi request reprint A novel HPLC procedure for detection and quantification of aminoacetone, a precursor of methylglyoxal, in biological samples
    Michael Kazachkov
    Neuropsychiatry Research Unit, Department of Psychiatry, University of Saskatchewan, A114 Medical Research Building, 103 Wiggins Road, Saskatoon, Sask, Canada
    J Chromatogr B Analyt Technol Biomed Life Sci 824:116-22. 2005
    ..Results confirm that aminoacetone is an endogenous substrate for SSAO. However, data also indicate that deamination is not the only catabolic pathway for aminoacetone...
  11. pmc Involvement of semicarbazide-sensitive amine oxidase-mediated deamination in lipopolysaccharide-induced pulmonary inflammation
    Peter H Yu
    Department of Psychiatry, Neuropsychiatry Research Unit, University of Saskatchewan, Saskatoon, Saskatchewan, Canada
    Am J Pathol 168:718-26. 2006
    ..Inhalation of methylamine also increased BAL neutrophil counts. Together, these results suggest a role for SSAO-mediated deamination in pulmonary inflammation...
  12. ncbi request reprint A novel sensitive high-performance liquid chromatography/electrochemical procedure for measuring formaldehyde produced from oxidative deamination of methylamine and in biological samples
    Peter H Yu
    Neuropsychiatry Research Unit, Department of Psychiatry, University of Saskatchewan, Saskatoon, Saskatchewan, Canada S7N 5E4
    Anal Biochem 318:285-90. 2003
    ..e., detection of picomole levels of formaldehyde, than the conventional methods. The procedure not only facilitates the assessment of SSAO activity in vitro but also is useful for assessing formaldehyde in tissues and biological fluids...
  13. ncbi request reprint Involvement of SSAO-mediated deamination in adipose glucose transport and weight gain in obese diabetic KKAy mice
    Peter H Yu
    Neuropsychiatry Research Unit, University of Saskatchewan, Saskatoon, Saskatchewan, Canada S7N 5E4
    Am J Physiol Endocrinol Metab 286:E634-41. 2004
    ..Highly selective SSAO inhibitors can effectively block induced glucose uptake. The results suggest that increased SSAO-mediated deamination may be concomitantly related to obesity and vascular disorders associated with type 2 diabetes...
  14. ncbi request reprint Evidence for in vivo scavenging by aminoguanidine of formaldehyde produced via semicarbazide-sensitive amine oxidase-mediated deamination
    Michael Kazachkov
    Department of Pharmacology, University of Saskatchewan, Saskatoon, Saskatchewan S7N 5E4, Canada
    J Pharmacol Exp Ther 322:1201-7. 2007
    ..Such reactions may contribute to its pharmacological effects in the treatment of vascular disorders associated with diabetic complications and other disorders...
  15. ncbi request reprint Protein cross-linkage induced by formaldehyde derived from semicarbazide-sensitive amine oxidase-mediated deamination of methylamine
    Diana Gubisne-Haberle
    Neuropsychiatry Research Unit, University of Saskatchewan, Saskatoon, SK S7N 5E4, Canada
    J Pharmacol Exp Ther 310:1125-32. 2004
    ..Our data support the hypothesis that the SSAO-induced production of formaldehyde may be involved in the alteration of protein structure, which may subsequently cause protein deposition associated with chronic pathological disorders...
  16. ncbi request reprint Potential inplications of endogenous aldehydes in beta-amyloid misfolding, oligomerization and fibrillogenesis
    Kun Chen
    Neuropsychiatry Research Unit, Department of Psychiatry, Saskatchewan Structural Sciences Centre, University of Saskatchewan, Saskatoon, Canada
    J Neurochem 99:1413-24. 2006
    ..The possible relevance to Alzheimer's disease of the effects of these aldehydes on beta-amyloid deposition is discussed...
  17. doi request reprint Low-dose creatine combined with protein during resistance training in older men
    Darren G Candow
    Faculty of Kinesiology and Health Studies, University of Regina, Regina, Saskatchewan, Canada
    Med Sci Sports Exerc 40:1645-52. 2008
    ....
  18. doi request reprint A fluorometric high-performance liquid chromatography procedure for simultaneous determination of methylamine and aminoacetone in blood and tissues
    Shengyuan Xiao
    Department of Pharmacology, University of Saskatchewan, Saskatoon, Saskatchewan, Canada S7N5E4
    Anal Biochem 384:20-6. 2009
    ..Methylamine and aminoacetone distributed unevenly among different tissues ranged from 0.1 to 27 nmol/g. To our knowledge, this is the first report on simultaneous determination of methylamine and aminoacetone in mammal tissues...