Allan H Young

Summary

Affiliation: University of British Columbia
Country: Canada

Publications

  1. ncbi request reprint Elevated prolactin responses to L-tryptophan infusion in medication-free depressed patients
    Richard J Porter
    Department of Psychological Medicine, Christchurch School of Medicine, New Zealand
    Psychopharmacology (Berl) 169:77-83. 2003
  2. ncbi request reprint Improvements in neurocognitive function and mood following adjunctive treatment with mifepristone (RU-486) in bipolar disorder
    Allan H Young
    Stanley Research Centre, School of Neurology, Neurobiology and Psychiatry, University of Newcastle upon Tyne, UK
    Neuropsychopharmacology 29:1538-45. 2004
  3. ncbi request reprint Antiglucocoticoid treatments for depression
    Allan H Young
    Department of Psychiatry, University of British Columbia, Vancoover, BC Canada
    Aust N Z J Psychiatry 40:402-5. 2006
  4. ncbi request reprint Treatment of bipolar disorder with antipsychotic medication: issues shared with schizophrenia
    Allan H Young
    Department of Psychiatry, University of British Columbia Institute of Mental Health, Vancouver, Canada
    J Clin Psychiatry 68:24-5. 2007
  5. doi request reprint A double-blind, placebo-controlled study of quetiapine and lithium monotherapy in adults in the acute phase of bipolar depression (EMBOLDEN I)
    Allan H Young
    Institute of Mental Health, Department of Psychiatry, The University of British Columbia, Vancouver, British Columbia BC V6T 1Z3, Canada
    J Clin Psychiatry 71:150-62. 2010
  6. ncbi request reprint Persistent antipsychotic polypharmacy and excessive dosing in the community psychiatric treatment setting: a review of medication profiles in 435 Canadian outpatients
    Ric M Procyshyn
    British Columbia Mental Health and Addictions Research Institute, A3 113, 938 W 28th Ave, Vancouver, British Columbia, Canada, V5Z 4H4
    J Clin Psychiatry 71:566-73. 2010
  7. doi request reprint Bipolar disorder: diagnostic conundrums and associated comorbidities
    Allan H Young
    Department of Psychiatry, University of British Columbia, Vancouver, British Columbia, Canada
    J Clin Psychiatry 70:e26. 2009
  8. doi request reprint Identifying neurocognitive impairment in depression using computerized testing
    Grant L Iverson
    University of British Columbia, Vancouver, Canada
    Appl Neuropsychol 16:254-61. 2009
  9. doi request reprint The role of hypothalamic pituitary-adrenal axis dysfunction in the etiology of depressive disorders
    Sean A McIsaac
    Institute of Mental Health, University of British Columbia, Vancouver, British Columbia, Canada
    Drugs Today (Barc) 45:127-33. 2009
  10. doi request reprint Strategies to achieve clinical effectiveness: refining existing therapies and pursuing emerging targets
    Sidney H Kennedy
    University Health Network, Department of Psychiatry, University of Toronto, Toronto, ON, Canada
    J Affect Disord 132:S21-8. 2011

Collaborators

Detail Information

Publications73

  1. ncbi request reprint Elevated prolactin responses to L-tryptophan infusion in medication-free depressed patients
    Richard J Porter
    Department of Psychological Medicine, Christchurch School of Medicine, New Zealand
    Psychopharmacology (Berl) 169:77-83. 2003
    ..Several previous neuroendocrine studies have demonstrated reduced 5-HT1A receptor function in major depressive disorder (MDD). However, hypercortisolaemia or previous drug treatment may have been significant confounds...
  2. ncbi request reprint Improvements in neurocognitive function and mood following adjunctive treatment with mifepristone (RU-486) in bipolar disorder
    Allan H Young
    Stanley Research Centre, School of Neurology, Neurobiology and Psychiatry, University of Newcastle upon Tyne, UK
    Neuropsychopharmacology 29:1538-45. 2004
    ..These data require replication but provide preliminary evidence that glucocorticoid receptor antagonists may have useful cognitive-enhancing and possibly antidepressant properties in bipolar disorder...
  3. ncbi request reprint Antiglucocoticoid treatments for depression
    Allan H Young
    Department of Psychiatry, University of British Columbia, Vancoover, BC Canada
    Aust N Z J Psychiatry 40:402-5. 2006
    ..To selectively review the literature germane to antiglucocoticoid treatments for depression...
  4. ncbi request reprint Treatment of bipolar disorder with antipsychotic medication: issues shared with schizophrenia
    Allan H Young
    Department of Psychiatry, University of British Columbia Institute of Mental Health, Vancouver, Canada
    J Clin Psychiatry 68:24-5. 2007
    ..These include similar motivations for switching due to limited efficacy and unacceptable adverse effects. Particular attention must be paid to the phase of treatment and coprescribed medications...
  5. doi request reprint A double-blind, placebo-controlled study of quetiapine and lithium monotherapy in adults in the acute phase of bipolar depression (EMBOLDEN I)
    Allan H Young
    Institute of Mental Health, Department of Psychiatry, The University of British Columbia, Vancouver, British Columbia BC V6T 1Z3, Canada
    J Clin Psychiatry 71:150-62. 2010
    ..The aim of this study was to compare the efficacy and tolerability of quetiapine and lithium monotherapy with that of placebo for a major depressive episode in bipolar disorder...
  6. ncbi request reprint Persistent antipsychotic polypharmacy and excessive dosing in the community psychiatric treatment setting: a review of medication profiles in 435 Canadian outpatients
    Ric M Procyshyn
    British Columbia Mental Health and Addictions Research Institute, A3 113, 938 W 28th Ave, Vancouver, British Columbia, Canada, V5Z 4H4
    J Clin Psychiatry 71:566-73. 2010
    ....
  7. doi request reprint Bipolar disorder: diagnostic conundrums and associated comorbidities
    Allan H Young
    Department of Psychiatry, University of British Columbia, Vancouver, British Columbia, Canada
    J Clin Psychiatry 70:e26. 2009
    ..To correctly diagnose patients with bipolar disorder, clinicians must be aware of associated comorbidities and methods of differentiating bipolar disorder from other illnesses...
  8. doi request reprint Identifying neurocognitive impairment in depression using computerized testing
    Grant L Iverson
    University of British Columbia, Vancouver, Canada
    Appl Neuropsychol 16:254-61. 2009
    ..Computerized testing, using the interpretive methodology presented, represents an efficient methodology for identifying cognitive problems in patients who present with untreated depression...
  9. doi request reprint The role of hypothalamic pituitary-adrenal axis dysfunction in the etiology of depressive disorders
    Sean A McIsaac
    Institute of Mental Health, University of British Columbia, Vancouver, British Columbia, Canada
    Drugs Today (Barc) 45:127-33. 2009
    ..Novel therapeutic approaches that modulate cortisol are now being evaluated experimentally in order to increase treatment options for depression and improve patient outcome...
  10. doi request reprint Strategies to achieve clinical effectiveness: refining existing therapies and pursuing emerging targets
    Sidney H Kennedy
    University Health Network, Department of Psychiatry, University of Toronto, Toronto, ON, Canada
    J Affect Disord 132:S21-8. 2011
    ..This is of particular importance when considering the long term use of antidepressant therapies for relapse prevention...
  11. doi request reprint Aripiprazole monotherapy in acute mania: 12-week randomised placebo- and haloperidol-controlled study
    Allan H Young
    Institute of Mental Health, Department of Psychiatry, University of British Columbia, Vancouver, Canada
    Br J Psychiatry 194:40-8. 2009
    ..Well-tolerated and effective therapies for bipolar mania are required...
  12. doi request reprint Canadian Network for Mood and Anxiety Treatments (CANMAT) and International Society for Bipolar Disorders (ISBD) collaborative update of CANMAT guidelines for the management of patients with bipolar disorder: update 2009
    Lakshmi N Yatham
    Department of Psychiatry, University of British Columbia, 2255 Wesbrook Mall, Vancouver, BC V6T 2A1, Canada
    Bipolar Disord 11:225-55. 2009
    ..Bipolar II disorder is frequently overlooked in treatment guidelines, but has an important clinical impact on patients' lives. This update provides an expanded look at bipolar II disorder...
  13. ncbi request reprint Lithium in mood disorders: increasing evidence base, declining use?
    Allan H Young
    Institute of Mental Health, University of British Columbia, University Boulevard, Vancouver, British Columbia, Canada V6T 1Z3
    Br J Psychiatry 191:474-6. 2007
    ..Recent meta-analyses confirm the benefits of maintenance lithium treatment and show that it reduces suicide and suicidality. Psychiatrists should continue to utilise this efficacious treatment for bipolar disorder...
  14. pmc Glucocorticoid receptors in the prefrontal cortex regulate stress-evoked dopamine efflux and aspects of executive function
    Kelly A Butts
    Department of Psychiatry, University of British Columbia, Vancouver, Canada V6T 1Z3
    Proc Natl Acad Sci U S A 108:18459-64. 2011
    ..Taken together, these data demonstrate that glucocorticoids act locally within the prefrontal cortex to modulate mesocortical dopamine efflux leading to the cognitive impairments observed during acute stress...
  15. ncbi request reprint Burden of bipolar depression: impact of disorder and medications on quality of life
    Erin E Michalak
    Division of Mood Disorders, Department of Psychiatry, University of British Columbia, Vancouver, British Columbia, Canada
    CNS Drugs 22:389-406. 2008
    ..Nonetheless, QOL appears to be a meaningful and important indicator of outcome and recovery in this patient population, and one that warrants further scientific interest and energy...
  16. ncbi request reprint A double blind, randomized, placebo-controlled trial of quetiapine as an add-on therapy to lithium or divalproex for the treatment of bipolar mania
    Lakshmi N Yatham
    Division of Mood Disorders, University of British Columbia, UBC Hospital, Vancouver, British Columbia, Canada
    Int Clin Psychopharmacol 22:212-20. 2007
    ..Overall, the combination of quetiapine with lithium or divalproex was well tolerated...
  17. doi request reprint Prenatal alcohol exposure and chronic mild stress differentially alter depressive- and anxiety-like behaviors in male and female offspring
    Kim G C Hellemans
    Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, British Columbia, Canada
    Alcohol Clin Exp Res 34:633-45. 2010
    ..We tested the hypothesis that exposure to stressors in adulthood may unmask an increased vulnerability to depressive- and anxiety-like behaviors in PAE animals...
  18. doi request reprint Rapid computerized assessment of neurocognitive deficits in bipolar disorder
    Grant L Iverson
    Department of Psychiatry, University of British Columbia, Vancouver, BC, V6T 2A1, Canada
    Appl Neuropsychol 16:207-13. 2009
    ..6% of the bipolar sample and only 6.4% of the control sample scored in this range. A subset of outpatients with bipolar disorder has frank neurocognitive impairments identifiable with this 30-40-minute computerized assessment battery...
  19. ncbi request reprint Persistent effects of mifepristone (RU-486) on cortisol levels in bipolar disorder and schizophrenia
    Peter Gallagher
    School of Neurology, Neurobiology and Psychiatry, Newcastle University, Leazes Wing, Royal Victoria Infirmary, Newcastle upon Tyne NE1 4LP, UK
    J Psychiatr Res 42:1037-41. 2008
    ..This may in part underlie the putative therapeutic effects of such drugs...
  20. ncbi request reprint Cortisol in mood disorders
    Allan H Young
    School of Neurology, Neurobiology and Psychiatry, University of Newcastle upon Tyne, Royal Victoria Infirmary, UK
    Stress 7:205-8. 2004
    ....
  21. ncbi request reprint Neuropsychological impairment in bipolar disorder: the relationship with glucocorticoid receptor function
    Stuart Watson
    The Stanley Research Centre, School of Neurology, Neurobiology, and Psychiatry, University of Newcastle upon Tyne, Newcastle upon Tyne, UK
    Bipolar Disord 8:85-90. 2006
    ..This suggests a potential link between neuropsychological and hypothalamic-pituitary-adrenal axis function. We examined the hypothesis that neuropsychological impairment in bipolar disorder is associated with abnormal GR function...
  22. ncbi request reprint The armamentarium of treatments for bipolar disorder: a review of the literature
    David A Cousins
    Newcastle Magnetic Resonance Centre, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne, UK
    Int J Neuropsychopharmacol 10:411-31. 2007
    ..Our results suggest a growing role for atypical antipsychotics in the treatment of bipolar disorder and further data are anticipated...
  23. ncbi request reprint The dex/CRH test--is it better than the DST?
    Stuart Watson
    School of Neurology, Neurobiology and Psychiatry, The Stanley Research Centre, University of Newcastle upon Tyne, Leazes Wing Psychiatry, Royal Victoria Infirmary, Newcastle upon Tyne NE1 4LP, UK
    Psychoneuroendocrinology 31:889-94. 2006
    ..9% and the specificity 71.4%. The sensitivity of 1500 h cortisol (the DST) was 66.6% and the specificity was 47.6%. This suggests that the two tests measure common pathology but that the dex/CRH test has better diagnostic utility...
  24. ncbi request reprint The art and science of switching of antipsychotic medications, part 1
    Peter J Weiden
    Department of Psychiatry, Schizophrenia Research Program, State University of New York Downstate Medical Center, Brooklyn, USA
    J Clin Psychiatry 67:e15. 2006
    ....
  25. ncbi request reprint Plasma cortisol-dehydroepiandrosterone (DHEA) ratios in schizophrenia and bipolar disorder
    Peter Gallagher
    School of Neurology, Neurobiology and Psychiatry, Newcastle University, UK
    Schizophr Res 90:258-65. 2007
    ..These data suggest that afternoon hypercortisolaemia is evident in symptomatic bipolar and schizophrenic patients compared to controls. However, an elevation in DHEA levels may represent a specific endocrine marker in schizophrenia...
  26. ncbi request reprint Lithium, arginine vasopressin and the dex/CRH test in mood disordered patients
    Stuart Watson
    The Stanley Research Centre, School of Neurology, Neurobiology and Psychiatry, University of Newcastle upon Tyne, UK
    Psychoneuroendocrinology 32:464-9. 2007
    ..These data demonstrate that patients taking lithium have elevated post-dexamethasone AVP levels compared to both healthy controls and patients not on lithium...
  27. ncbi request reprint Changes in brain-derived neurotrophic factor following treatment with mifepristone in bipolar disorder and schizophrenia
    Paul Mackin
    School of Neurology, Neurobiology and Psychiatry, University of Newcastle upon Tyne, Leazes Wing Psychiatry, Royal Victoria Infirmary, Newcastle upon Tyne, NE1 4LP, UK
    Aust N Z J Psychiatry 41:321-6. 2007
    ..The aim of the present study was to investigate BDNF levels in patients with bipolar disorder and schizophrenia before and after treatment with the glucocorticoid receptor antagonist mifepristone...
  28. ncbi request reprint Effectiveness of mood stabilizers and antipsychotics in the maintenance phase of bipolar disorder: a systematic review of randomized controlled trials
    Lesley A Smith
    Medical Research Matters, Eynsham, UK
    Bipolar Disord 9:394-412. 2007
    ..Bipolar disorder (BD) is a leading cause of disability. Systematic reviews of randomized trials for the treatment of the maintenance phase of BD are lacking...
  29. ncbi request reprint Effects of adjunctive mifepristone (RU-486) administration on neurocognitive function and symptoms in schizophrenia
    Peter Gallagher
    Stanley Research Centre, School of Neurology, Neurobiology and Psychiatry, University of Newcastle upon Tyne, United Kingdom
    Biol Psychiatry 57:155-61. 2005
    ..We hypothesized that antiglucocorticoid treatments, particularly glucocorticoid receptor (GR) antagonists, would improve neurocognitive functioning and clinical symptoms in this disorder...
  30. ncbi request reprint International Consensus Group on Bipolar I Depression Treatment Guidelines
    Joseph R Calabrese
    Department of Psychiatry, Case Western Reserve University, Cleveland, OH, USA
    J Clin Psychiatry 65:571-9. 2004
  31. ncbi request reprint Hypothalamic-pituitary-adrenal axis function in patients with bipolar disorder
    Stuart Watson
    The Stanley Research Centre, University of Newcastle upon Tyne, The Royal Victoria Infirmary, Newcastle upon Tyne, UK
    Br J Psychiatry 184:496-502. 2004
    ....
  32. pmc Effects of acute tryptophan depletion on executive function in healthy male volunteers
    Peter Gallagher
    Stanley Research Centre, School of Neurology, Neurobiology and Psychiatry, University of Newcastle upon Tyne, NE1 4LP, UK
    BMC Psychiatry 3:10. 2003
    ....
  33. ncbi request reprint Impaired working memory monitoring in euthymic bipolar patients
    Jill M Thompson
    School of Neurology, Neurobiology and Psychiatry, University of Newcastle upon Tyne, Newcastle upon Tyne, UK
    Bipolar Disord 9:478-89. 2007
    ..However, the component operations that contribute to this deficit remain unclear. The aim of the present study was to further profile the nature and specificity of WM impairment in euthymic BD...
  34. ncbi request reprint Dementia rating and nicotinic receptor expression in the prefrontal cortex in schizophrenia
    Carmen M Martin-Ruiz
    Institute for Ageing and Health, Newcastle General Hospital, Newcastle upon Tyne, United Kingdom
    Biol Psychiatry 54:1222-33. 2003
    ..The etiology of dementia that occurs in patients with schizophrenia is not well understood. Nicotinic acetylcholine receptors have been implicated in cognitive function, and deficits in these receptors have been reported in schizophrenia...
  35. ncbi request reprint The British Association for Psychopharmacology guidelines for treatment of bipolar disorder: a summary
    Guy M Goodwin
    J Psychopharmacol 17:3-6. 2003
    ..It is timely since awareness of the specific needs of bipolar patients is growing and there is an increased choice of effective treatments for all phases of the illness...
  36. ncbi request reprint The nature of abnormal language processing in euthymic bipolar I disorder: evidence for a relationship between task demand and prefrontal function
    Vivienne A Curtis
    Division of Psychological Medicine, Institute of Psychiatry, London, UK
    Bipolar Disord 9:358-69. 2007
    ..We used functional magnetic resonance imaging (fMRI) to investigate the core components of language processing as well as the impact of task demand in a group of bipolar subjects...
  37. ncbi request reprint Developing the BALANCE trail--the role of the pilot study and start-up phase
    Jennifer M Rendell
    Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, UK
    Bipolar Disord 6:26-31. 2004
    ..This report describes the adaptations to the initial design and trial procedures following the initial phases of the study. The rationale for the trial and full protocol have been published elsewhere...
  38. ncbi request reprint Corticosteroid-serotonin interactions in depression: a review of the human evidence
    Richard J Porter
    Department of Psychological Medicine, Christchurch School of Medicine, Christchurch, New Zealand
    Psychopharmacology (Berl) 173:1-17. 2004
    ..It has been suggested that corticosteroid-serotonin interactions are central to the pathophysiology of depression. These interactions have been investigated in healthy and depressed humans, primarily using neuroendocrine techniques...
  39. ncbi request reprint Neurocognitive function following remission in major depressive disorder: potential objective marker of response?
    Peter Gallagher
    School of Neurology, Neurobiology and Psychiatry, Newcastle University, Leazes Wing Psychiatry, Royal Victoria Infirmary, Newcastle upon Tyne, NE1 4LP, UK
    Aust N Z J Psychiatry 41:54-61. 2007
    ..Neurocognitive deficits have been widely reported in patients with mood disorders. However, relatively little is known of the short-term trajectory of neurocognitive improvement once treatment has been initiated...
  40. ncbi request reprint Basal activity of the HPA axis and cognitive function in anorexia nervosa
    Julie A Seed
    Division of Psychology, University of Northumbria, New Castle upon Tyne, UK
    Int J Neuropsychopharmacol 5:17-25. 2002
    ..The limitations of cortisol as an indicator of HPA axis activity are discussed...
  41. ncbi request reprint The effects of acute tryptophan depletion on neuropsychological function
    John H Hughes
    University of Newcastle upon Tyne, Department of Psychiatry, The Royal Victoria Infirmary, Newcastle upon Tyne, UK
    J Psychopharmacol 17:300-9. 2003
    ....
  42. ncbi request reprint Elevation of the cortisol-dehydroepiandrosterone ratio in drug-free depressed patients
    Allan H Young
    Department of Psychiatry, Leazes Wing, Royal Victoria Infirmary, University of Newcastle upon Tyne, Newcastle upon Tyne NE1 4LP, UK
    Am J Psychiatry 159:1237-9. 2002
    ..The authors examined the ratio of cortisol to DHEA in drug-free depressed patients and a matched comparison group...
  43. ncbi request reprint Acute tryptophan depletion attenuates auditory event related potentials in bipolar disorder: a preliminary study
    Allan H Young
    Stanley Foundation Research Centre, Department of Psychiatry, University of Newcastle upon Tyne, Royal Victoria Infirmary, Newcastle upon Tyne NE1 4LP, UK
    J Affect Disord 69:83-92. 2002
    ..The EEG may therefore be a sensitive marker of 5-HT function in bipolar disorder. We examined the effects of acute tryptophan depletion (ATD) on EEG activity in bipolar patients...
  44. ncbi request reprint The effects of sub-chronic administration of hydrocortisone on hormonal and psychological responses to L-tryptophan in normal male volunteers
    Richard J Porter
    Department of Psychological Medicine, Christchurch School of Medicine, Christchurch, New Zealand
    Psychopharmacology (Berl) 163:68-75. 2002
    ..This response has been shown to be reduced following acute administration of hydrocortisone, and we hypothesised that sub-chronic administration of hydrocortisone would also blunt it...
  45. ncbi request reprint A randomized controlled trial of fluvoxamine in prostatodynia, a male somatoform pain disorder
    Douglas Turkington
    Department of Psychiatry, Royal Victoria Infirmary, Newcastle upon Tyne, United Kingdom
    J Clin Psychiatry 63:778-81. 2002
    ..It presents with urogenital pain and urinary symptoms. Failure of conventional treatment and a successful uncontrolled pilot study with fluvoxamine in this condition prompted this study...
  46. ncbi request reprint Flattening the corticosterone rhythm attenuates 5-HT1A autoreceptor function in the rat: relevance for depression
    Melville M Leitch
    Psychobiology Research Group, Stanley Research Centre, The Medical School, University of Newcastle upon Tyne, UK
    Neuropsychopharmacology 28:119-25. 2003
    ..These findings suggest that resolution of cortisol abnormalities may be a valuable target for pharmacotherapy in the treatment of depression...
  47. ncbi request reprint Evidence for a late onset bipolar-I disorder sub-group from 50 years
    Stephen R J Moorhead
    Department of Psychiatry, University of Newcastle upon Tyne, Royal Victoria Infirmary, Newcastle upon Tyne NE1 4LP, UK
    J Affect Disord 73:271-7. 2003
    ..We examined the relationship between age of onset and family history in bipolar-I disorder in an attempt to identify subgroups...
  48. ncbi request reprint GABA-ergic drugs: exit stage left, enter stage right
    Heather Ashton
    Department of Psychiatry, University of Newcastle upon Tyne, Royal Victoria Infirmary, Newcastle upon Tyne, UK
    J Psychopharmacol 17:174-8. 2003
    ..It remains to be seen whether long-term use leads to tolerance, dependence and withdrawal or discontinuation reactions...
  49. ncbi request reprint The pharmacological treatment of bipolar affective disorder: practice is improving but could still be better
    Adrian J Lloyd
    School of Neurology, Neurobiology and Psychiatry, University of Newcastle, Newcastle upon Tyne, UK
    J Psychopharmacol 17:230-3. 2003
    ..However, it still falls short in a number of respects of such recommendations as exist and this requires further examination and monitoring...
  50. ncbi request reprint Effect of sub-chronic hydrocortisone on responses to amphetamine in normal male volunteers
    Andrea J Hearn
    Psychobiology Research Group, School of Neurology, Neurobiology and Psychiatry, University of Newcastle upon Tyne, Newcastle, UK
    Psychopharmacology (Berl) 171:458-64. 2004
    ..Enhancement of dopamine (DA) release by corticosteroids may be of aetiological importance in substance misuse...
  51. ncbi request reprint Effects of acute tryptophan depletion on cognitive function in euthymic bipolar patients
    John H Hughes
    Stanley Foundation Research Centre, Department of Psychiatry, University of Newcastle upon Tyne, Leazes Wing, Royal Victoria Infirmary, Newcastle upon Tyne NE1 4LP, UK
    Eur Neuropsychopharmacol 12:123-8. 2002
    ..Effects on specific 'executive' functions are less clear, and should be the focus for future research...
  52. ncbi request reprint Soft neurological signs do not increase with age in euthymic bipolar subjects
    Utpal Goswami
    Department of Psychiatry, West Park Hospital, Darlington, Co Durham, DL2 2TS, UK
    J Affect Disord 103:99-103. 2007
    ..This paper explores changes in SNS with ageing to ascertain whether BD is associated with a progressive neurological decline or a relatively fixed, persistent deficit...
  53. ncbi request reprint Tolerability of high-dose venlafaxine in depressed patients
    C Louise Harrison
    School of Neurology, Neurobiology and Psychiatry, Psychiatry, Royal Victoria Infirmary, Newcastle upon Tyne, UK
    J Psychopharmacol 18:200-4. 2004
    ..e. up to 600 mg daily). However, increased frequency and severity of reported side-effects in the high-dose group are not associated with increased rates of discontinuation...
  54. ncbi request reprint Rapid cycling bipolar disorder: historical overview and focus on emerging treatments
    Paul Mackin
    School of Neurology, Neurobiology and Psychiatry, Department of Psychiatry, University of Newcastle upon Tyne, Royal Victoria Infirmary, Newcastle upon Tyne, UK
    Bipolar Disord 6:523-9. 2004
    ....
  55. ncbi request reprint Assessing cortisol and dehydroepiandrosterone (DHEA) in saliva: effects of collection method
    Peter Gallagher
    School of Neurology, Neurobiology and Psychiatry, University of Newcastle upon Tyne, Newcastle upon Tyne, UK
    J Psychopharmacol 20:643-9. 2006
    ..2;R(2) 0.04). It is crucial that future studies are aware of these issues and are cognizant of the effects of the method of collection when examining steroid levels in saliva...
  56. ncbi request reprint Genetic variation of brain-derived neurotrophic factor (BDNF) in bipolar disorder: case-control study of over 3000 individuals from the UK
    Elaine K Green
    Department of Psychological Medicine, Henry Wellcome Building, Wales College of Medicine, Cardiff University, Heath Park, Cardiff CF4 4XN, Wales, UK
    Br J Psychiatry 188:21-5. 2006
    ..Three family-based studies have shown association of the common Valine (Val) allele of the Val66Met polymorphism of the BDNF gene with susceptibility to bipolar disorder...
  57. ncbi request reprint Effect of lithium and lithium withdrawal on potassium-evoked dopamine release and tyrosine hydroxylase expression in the rat
    Lindsey Ferrie
    Psychobiology Research Group, School of Neurology, Neurobiology and Psychiatry, The Medical School, Newcastle upon Tyne, UK
    Int J Neuropsychopharmacol 9:729-35. 2006
    ..These data suggest that decreased dopamine release may mediate the mood stabilizing action of lithium. However, in this paradigm a rebound increase in dopamine release was not found after withdrawal from lithium treatment...
  58. ncbi request reprint Post-dexamethasone arginine vasopressin levels in patients with severe mood disorders
    Stuart Watson
    Department of Psychiatry, Leazes Wing, Royal Victoria Infirmary, University of Newcastle upon Tyne, Newcastle NE1 4LP, UK
    J Psychiatr Res 40:353-9. 2006
    ....
  59. ncbi request reprint A functional MRI study of working memory task in euthymic bipolar disorder: evidence for task-specific dysfunction
    Paul J Monks
    Division of Psychological Medicine, Institute of Psychiatry, London, UK
    Bipolar Disord 6:550-64. 2004
    ..We hypothesized that neuronal dysfunction would be specific to the network underlying the executive rather than the phonological loop component of working memory...
  60. ncbi request reprint Using guidelines in real clinical situations: clozapine and breast feeding in bipolar disorder
    Guy Goodwin
    University Department of Psychiatry, Warneford Hospital, Oxford, UK
    J Psychopharmacol 19:317-8. 2005
  61. ncbi request reprint Temporal stability of the dex/CRH test in patients with rapid-cycling bipolar I disorder: a pilot study
    Stuart Watson
    Department of Psychiatry, Leazes Wing, Royal Victoria Infirmary, Queen Victoria Road, Newcastle upon Tyne NE1 4LP, U K
    Aust N Z J Psychiatry 39:244-8. 2005
    ..To examine the hypothesis that hypothalamic-pituitary-adrenal (HPA) axis function is a trait abnormality in bipolar disorder...
  62. ncbi request reprint Lithium in maintenance therapy for bipolar disorder
    Allan H Young
    University of Newcastle, Newcastle upon Tyne, UK
    J Psychopharmacol 20:17-22. 2006
    ..It is also associated with an increased liability for new episodes, both manic and depressive, consequent upon stoppage of treatment. These factors limit the clinical effectiveness of lithium...
  63. ncbi request reprint Managing the aftermath of mania - Newcastle, 2 September 2005: Consensus Meeting Statement
    Allan H Young
    University of Newcastle, Newcastle upon Tyne, UK
    J Psychopharmacol 20:51-4. 2006
  64. ncbi request reprint Bipolar patients show mood-congruent biases in sensitivity to facial expressions of emotion when exhibiting depressed symptoms, but not when exhibiting manic symptoms
    John Gray
    St Nicholas Hospital and University of Newcastle upon Tyne, UK
    Cogn Neuropsychiatry 11:505-20. 2006
    ....
  65. ncbi request reprint Sex differences in the effect of acute tryptophan depletion on declarative episodic memory: a pooled analysis of nine studies
    Anke Sambeth
    Department of Neurocognition, Faculty of Psychology, Maastricht University, P O Box 616, 6200 MD Maastricht, The Netherlands
    Neurosci Biobehav Rev 31:516-29. 2007
    ..The findings provide further support for a critical role of serotonin in declarative episodic memory...
  66. ncbi request reprint QTc interval measurement and metabolic parameters in psychiatric patients taking typical or atypical antipsychotic drugs: a preliminary study
    Paul Mackin
    School of Neurology, Neurobiology, and Psychiatry, University of Newcastle upon Tyne, Leazes Wing, Royal Victoria Infirmary, Newcastle upon Tyne NE1 4LP, United Kingdom
    J Clin Psychiatry 66:1386-91. 2005
    ..Abnormalities of glucose homeostasis, which may be more common in individuals with major mood disorders and schizophrenia, also affect the QTc interval...
  67. ncbi request reprint Culture and assessment of manic symptoms
    Paul Mackin
    School of Neurology, Neurobiology and Psychiatry, University of Newcastle upon Tyne, Royal Victoria Infirmary, Queen Victoria Road, Newcastle upon Tyne NE1 4LP, UK
    Br J Psychiatry 189:379-80. 2006
    ..001) and between India and UK (P<0.001) rater groups. Overall, differences between India and US rater groups were less marked (P=0.28). These differences suggest that cultural biases influence the interpretation of manic symptoms...
  68. ncbi request reprint Executive and visuospatial sketchpad resources in euthymic bipolar disorder: Implications for visuospatial working memory architecture
    Jill M Thompson
    University of Newcastle upon Tyne, UK
    Memory 14:437-51. 2006
    ..ANCOVA indicated that impaired executive function underpinned patients' CBT performance. Implications for the interface between executive and slave systems of working memory are discussed...
  69. ncbi request reprint Perception of facial expressions of emotion in bipolar disorder
    Helen R Venn
    Stanley Research Centre, School of Neurology, Neurobiology and Psychiatry, University of Newcastle upon Tyne, UK
    Bipolar Disord 6:286-93. 2004
    ..We examined whether altered perception of emotion reflects an underlying trait-like effect in affective disorder by examining facial expression perception in euthymic bipolar patients...
  70. ncbi request reprint Neurocognitive function in unaffected first-degree relatives of patients with bipolar disorder: a preliminary report
    I Nicol Ferrier
    School of Neurology, Neurobiology and Psychiatry, University of Newcastle upon Tyne, UK
    Bipolar Disord 6:319-22. 2004
    ..This study, therefore, examined neuropsychological function in healthy first-degree relatives of patients with BD...
  71. ncbi request reprint A meta-analysis of cognitive deficits in euthymic patients with bipolar disorder
    Lucy J Robinson
    School of Neurology, Neurobiology and Psychiatry Psychiatry, University of Newcastle upon Tyne, Leazes Wing, Royal Victoria Infirmary, Queen Victoria Road, Newcastle upon Tyne, NE1 4LP, UK
    J Affect Disord 93:105-15. 2006
    ..This review aims to combine data from available studies to identify the profile of neuropsychological deficits in euthymic bipolar patients and quantify their magnitude...
  72. ncbi request reprint Neuropsychological dysfunction, soft neurological signs and social disability in euthymic patients with bipolar disorder
    Utpal Goswami
    Lady Hardinge Medical College and Associated Hospitals, New Delhi, India
    Br J Psychiatry 188:366-73. 2006
    ..Neurocognitive deficits exist in euthymic patients with bipolar disorder, but relationships between symptoms, psychosocial and neurological factors remain uncertain...
  73. ncbi request reprint Neurocognitive impairment in euthymic patients with bipolar affective disorder
    Jill M Thompson
    Stanley Research Centre, School of Neurology, Neurobiology and Psychiatry, University of Newcastle upon Tyne, Leazes Wing, Royal Victoria Infirmary, Newcastle upon Tyne NE1 4LP, UK
    Br J Psychiatry 186:32-40. 2005
    ..However, methodological issues such as the effect of residual mood symptoms and hypercortisolaemia may confound such studies...