V Wee Yong


Affiliation: University of Calgary
Country: Canada


  1. Yong H, Rawji K, Ghorbani S, Xue M, Yong V. The benefits of neuroinflammation for the repair of the injured central nervous system. Cell Mol Immunol. 2019;: pubmed publisher
    ..Finally, we highlight treatment strategies that harness the benefits of neuroinflammation for CNS regenerative responses. ..
  2. Sarkar S, Poon C, Mirzaei R, Rawji K, Hader W, Bose P, et al. Microglia induces Gas1 expression in human brain tumor-initiating cells to reduce tumorigenecity. Sci Rep. 2018;8:15286 pubmed publisher
    ..In conclusion, this study has identified Gas1 as a novel factor and mechanism through which microglia arrest the growth of BTICs for anti-tumor property. ..
  3. Jensen S, Michaels N, Ilyntskyy S, Keough M, Kovalchuk O, Yong V. Multimodal Enhancement of Remyelination by Exercise with a Pivotal Role for Oligodendroglial PGC1?. Cell Rep. 2018;24:3167-3179 pubmed publisher
    ..Our study demonstrates physical activity as an integrative means to enhance remyelination and details a multimodal mechanism including the pivotal PGC1?-dependent enhancement of myelin thickness. ..
  4. Kaushik D, Hahn J, Yong V. EMMPRIN, an upstream regulator of MMPs, in CNS biology. Matrix Biol. 2015;44-46:138-46 pubmed publisher
    ..This review summarizes the current understanding of EMMPRIN's involvement in CNS homeostasis, its possible roles in escalating or reducing neural injury, and the mechanisms of EMMPRIN including and apart from MMP induction. ..
  5. Keough M, Jensen S, Yong V. Experimental demyelination and remyelination of murine spinal cord by focal injection of lysolecithin. J Vis Exp. 2015;: pubmed publisher
    ..This procedure is important not only for studying the normal events involved in the remyelination process, but also as a pre-clinical tool for screening candidate remyelination-promoting therapeutics. ..
  6. Döring A, Sloka S, Lau L, Mishra M, van Minnen J, Zhang X, et al. Stimulation of monocytes, macrophages, and microglia by amphotericin B and macrophage colony-stimulating factor promotes remyelination. J Neurosci. 2015;35:1136-48 pubmed publisher
    ..Our results have identified candidates among currently used medications as potential therapies for the repair of myelin. ..
  7. Stephenson E, Yong V. Pro-inflammatory roles of chondroitin sulfate proteoglycans in disorders of the central nervous system. Matrix Biol. 2018;71-72:432-442 pubmed publisher
    ..This Review aims to give new insights into the remodeling of chondroitin sulfate proteoglycans during inflammation, and how these matrix glycoproteins are able to drive neuroinflammation. ..
  8. Hahn J, Kaushik D, Yong V. The role of EMMPRIN in T cell biology and immunological diseases. J Leukoc Biol. 2015;98:33-48 pubmed publisher
    ..Here, we review what is known about EMMPRIN in numerous immunologic/inflammatory disease conditions with a particular focus on its complex roles in T cell biology. ..
  9. Zhornitsky S, Johnson T, Metz L, Weiss S, Yong V. Prolactin in combination with interferon-β reduces disease severity in an animal model of multiple sclerosis. J Neuroinflammation. 2015;12:55 pubmed publisher
    ..Histological analyses corroborated the clinical EAE data. These results suggest that prolactin may be beneficial when administered in combination with interferon-β in MS. ..

More Information


  1. Jensen S, Yong V. Activity-Dependent and Experience-Driven Myelination Provide New Directions for the Management of Multiple Sclerosis. Trends Neurosci. 2016;39:356-365 pubmed publisher
    ..These advances present new considerations for the management of multiple sclerosis and open up new approaches to facilitate remyelination following pathological demyelination. ..
  2. request reprint
    Hahn J, Kaushik D, Mishra M, Wang J, Silva C, Yong V. Impact of Minocycline on Extracellular Matrix Metalloproteinase Inducer, a Factor Implicated in Multiple Sclerosis Immunopathogenesis. J Immunol. 2016;197:3850-3860 pubmed
    ..Overall, minocycline attenuated the activation-induced elevation of EMMPRIN on T cells in culture and in EAE mice, correspondent with reduced immune function and EAE CNS pathology. ..
  3. Mirzaei R, Sarkar S, Yong V. T Cell Exhaustion in Glioblastoma: Intricacies of Immune Checkpoints. Trends Immunol. 2017;38:104-115 pubmed publisher
  4. Sarkar S, Mirzaei R, Zemp F, Wei W, Senger D, Robbins S, et al. Activation of NOTCH Signaling by Tenascin-C Promotes Growth of Human Brain Tumor-Initiating Cells. Cancer Res. 2017;77:3231-3243 pubmed publisher
    ..i>Cancer Res; 77(12); 3231-43. ©2017 AACR. ..
  5. Rogers J, Mishra M, Hahn J, Greene C, Yates R, Metz L, et al. Gestational bisphenol-A exposure lowers the threshold for autoimmunity in a model of multiple sclerosis. Proc Natl Acad Sci U S A. 2017;114:4999-5004 pubmed publisher
    ..Neutralizing granulocyte-colony stimulating factor blocked susceptibility to disease in bisphenol-A mice. Early life exposure to bisphenol-A may represent an environmental consideration in multiple sclerosis. ..
  6. Faissner S, Mishra M, Kaushik D, Wang J, Fan Y, Silva C, et al. Systematic screening of generic drugs for progressive multiple sclerosis identifies clomipramine as a promising therapeutic. Nat Commun. 2017;8:1990 pubmed publisher
    ..In summary, we present a systematic approach to identify generic medications for progressive multiple sclerosis with the potential to advance rapidly into clinical trials, and we highlight clomipramine for further development. ..
  7. Rawji K, Kappen J, Tang W, Teo W, Plemel J, Stys P, et al. Deficient Surveillance and Phagocytic Activity of Myeloid Cells Within Demyelinated Lesions in Aging Mice Visualized by Ex Vivo Live Multiphoton Imaging. J Neurosci. 2018;38:1973-1988 pubmed publisher
    ..Medications to stimulate deficient aging myeloid cells should not only increase their representation, but also enter into lesions to stimulate their activity. ..
  8. Rawji K, Mishra M, Michaels N, Rivest S, Stys P, Yong V. Immunosenescence of microglia and macrophages: impact on the ageing central nervous system. Brain. 2016;139:653-61 pubmed publisher
    ..Rejuvenation of ageing macrophage/microglia may preserve neurological integrity and promote regeneration in the ageing central nervous system. ..
  9. Yong V, Marks S. The interplay between the immune and central nervous systems in neuronal injury. Neurology. 2010;74 Suppl 1:S9-S16 pubmed publisher
    ..The interplay between components of the immune system and CNS contributes both to healthy brain function and to the pathogenesis of neurodegenerative diseases such as multiple sclerosis. ..