L N Yatham

Summary

Affiliation: University of British Columbia
Country: Canada

Publications

  1. ncbi request reprint Oxcarbazepine add-on in the treatment of refractory bipolar disorder
    Wetid Pratoomsri
    Mood Disorders Clinical Research Unit, The University of British Columbia, Vancouver, BC, Canada
    Bipolar Disord 7:37-42. 2005
  2. ncbi request reprint Oxcarbazepine in the treatment of bipolar disorder: a review
    Wetid Pratoomsri
    Mood Disorders Centre of Excellence, University of British Columbia, Vancouver
    Can J Psychiatry 51:540-5. 2006
  3. ncbi request reprint Assessment of noradrenergic functioning in patients with non-combat-related posttraumatic stress disorder: a study with desmethylimipramine and orthostatic challenges
    L N Yatham
    Department of Psychiatry, University of British Columbia, Vancouver, Canada
    Psychiatry Res 63:1-6. 1996
  4. ncbi request reprint PET study of the effects of valproate on dopamine D(2) receptors in neuroleptic- and mood-stabilizer-naive patients with nonpsychotic mania
    Lakshmi N Yatham
    Mood Disorders Clinical Research Unit, University of British Columbia, 2255 Wesbrook Mall, Vancouver, BC, Canada V6T 2A1
    Am J Psychiatry 159:1718-23. 2002
  5. ncbi request reprint PET study of [(18)F]6-fluoro-L-dopa uptake in neuroleptic- and mood-stabilizer-naive first-episode nonpsychotic mania: effects of treatment with divalproex sodium
    Lakshmi N Yatham
    Department of Psychiatry, University of British Columbia, Vancouver, Canada
    Am J Psychiatry 159:768-74. 2002
  6. ncbi request reprint Effects of rapid tryptophan depletion on brain 5-HT(2) receptors: a PET study
    L N Yatham
    Division of Mood Disorders, The University of British Columbia, Canada
    Br J Psychiatry 178:448-53. 2001
  7. ncbi request reprint A PET study of brain 5-HT2 receptors and their correlation with platelet 5-HT2 receptors in healthy humans
    L N Yatham
    Division of Mood Disorders Clinical Research Unit, The University of British Columbia, Vancouver, Canada
    Psychopharmacology (Berl) 151:424-7. 2000
  8. ncbi request reprint Brain serotonin2 receptors in major depression: a positron emission tomography study
    L N Yatham
    Mood Disorders Clinical Research Unit, The University of British Columbia, 2255 Wesbrook Mall, Vancouver, British Columbia, Canada V6T 2A1
    Arch Gen Psychiatry 57:850-8. 2000
  9. ncbi request reprint Hypothermic, ACTH, and cortisol responses to ipsapirone in patients with mania and healthy controls
    L N Yatham
    Department of Psychiatry, The University of British Columbia, Vancouver, Canada
    J Affect Disord 54:295-301. 1999
  10. ncbi request reprint Decrease in brain serotonin 2 receptor binding in patients with major depression following desipramine treatment: a positron emission tomography study with fluorine-18-labeled setoperone
    L N Yatham
    Division of Mood Disorders, The University of British Columbia, Vancouver, Canada
    Arch Gen Psychiatry 56:705-11. 1999

Collaborators

Detail Information

Publications74

  1. ncbi request reprint Oxcarbazepine add-on in the treatment of refractory bipolar disorder
    Wetid Pratoomsri
    Mood Disorders Clinical Research Unit, The University of British Columbia, Vancouver, BC, Canada
    Bipolar Disord 7:37-42. 2005
    ..To assess the effectiveness and safety of oxcarbazepine (OXC) in bipolar disorder (BD) and related conditions...
  2. ncbi request reprint Oxcarbazepine in the treatment of bipolar disorder: a review
    Wetid Pratoomsri
    Mood Disorders Centre of Excellence, University of British Columbia, Vancouver
    Can J Psychiatry 51:540-5. 2006
    ..To review the data on the efficacy of oxcarbazepine (OXC) in bipolar disorder (BD) and to provide recommendations for clinicians on the use of this medication in treating BD...
  3. ncbi request reprint Assessment of noradrenergic functioning in patients with non-combat-related posttraumatic stress disorder: a study with desmethylimipramine and orthostatic challenges
    L N Yatham
    Department of Psychiatry, University of British Columbia, Vancouver, Canada
    Psychiatry Res 63:1-6. 1996
    ..Overall, these findings suggest that non-combat-related PTSD patients have peripheral noradrenergic dysregulation, but central postsynaptic alpha 2-adrenergic receptor sensitivity is not altered in this patient population...
  4. ncbi request reprint PET study of the effects of valproate on dopamine D(2) receptors in neuroleptic- and mood-stabilizer-naive patients with nonpsychotic mania
    Lakshmi N Yatham
    Mood Disorders Clinical Research Unit, University of British Columbia, 2255 Wesbrook Mall, Vancouver, BC, Canada V6T 2A1
    Am J Psychiatry 159:1718-23. 2002
    ..The purpose of this study was to further examine D(2) receptor density in a larger sample of nonpsychotic manic patients by using positron emission tomography (PET) and [(11)C]raclopride...
  5. ncbi request reprint PET study of [(18)F]6-fluoro-L-dopa uptake in neuroleptic- and mood-stabilizer-naive first-episode nonpsychotic mania: effects of treatment with divalproex sodium
    Lakshmi N Yatham
    Department of Psychiatry, University of British Columbia, Vancouver, Canada
    Am J Psychiatry 159:768-74. 2002
    ....
  6. ncbi request reprint Effects of rapid tryptophan depletion on brain 5-HT(2) receptors: a PET study
    L N Yatham
    Division of Mood Disorders, The University of British Columbia, Canada
    Br J Psychiatry 178:448-53. 2001
    ..The mechanism by which rapid tryptophan depletion (RTD) paradigm induces depressive relapse in recently remitted patients with depression is unknown...
  7. ncbi request reprint A PET study of brain 5-HT2 receptors and their correlation with platelet 5-HT2 receptors in healthy humans
    L N Yatham
    Division of Mood Disorders Clinical Research Unit, The University of British Columbia, Vancouver, Canada
    Psychopharmacology (Berl) 151:424-7. 2000
    ..Platelets share many properties with brain serotonergic neurons such as active 5-hydroxytryptamine (5-HT) transport, 5-HT2 receptors, and mitochondrial monoamine oxidase...
  8. ncbi request reprint Brain serotonin2 receptors in major depression: a positron emission tomography study
    L N Yatham
    Mood Disorders Clinical Research Unit, The University of British Columbia, 2255 Wesbrook Mall, Vancouver, British Columbia, Canada V6T 2A1
    Arch Gen Psychiatry 57:850-8. 2000
    ..1 +/- 9.5 years; range, 22-60 years) and 20 healthy controls similar in age (37.2 +/- 12.6 years; range, 19-59 years) using positron emission tomography and setoperone labeled with fluorine 18 ([(18)F]setoperone)...
  9. ncbi request reprint Hypothermic, ACTH, and cortisol responses to ipsapirone in patients with mania and healthy controls
    L N Yatham
    Department of Psychiatry, The University of British Columbia, Vancouver, Canada
    J Affect Disord 54:295-301. 1999
    ....
  10. ncbi request reprint Decrease in brain serotonin 2 receptor binding in patients with major depression following desipramine treatment: a positron emission tomography study with fluorine-18-labeled setoperone
    L N Yatham
    Division of Mood Disorders, The University of British Columbia, Vancouver, Canada
    Arch Gen Psychiatry 56:705-11. 1999
    ..Our purpose, therefore, was to assess the effects of treatment with desipramine hydrochloride on brain 5-HT2 receptors in depressed patients using positron emission tomography (PET) and fluorine-18 (18F)-labeled setoperone...
  11. ncbi request reprint Bipolar depression: treatment options
    L N Yatham
    Department of Psychiatry, University of British Columbia, Vancouver
    Can J Psychiatry 42:87S-91S. 1997
    ..To review studies on treatments for bipolar depression and make recommendations for practising clinicians treating patients with bipolar depression...
  12. ncbi request reprint Effects of light therapy on suicidal ideation in patients with winter depression
    R W Lam
    Department of Psychiatry, University of British Columbia, and the University of British Columbia Hospital, Vancouver, Canada
    J Clin Psychiatry 61:30-2. 2000
    ..This retrospective study sought to determine the effects of light therapy on suicidal ideation in patients with SAD...
  13. ncbi request reprint L-tryptophan augmentation of light therapy in patients with seasonal affective disorder
    R W Lam
    Department of Psychiatry, University of British Columbia, Vancouver
    Can J Psychiatry 42:303-6. 1997
    ..Given the evidence for serotonergic dysregulation in SAD, we examined the possible role of l-tryptophan as an augmentation strategy for nonresponders and partial responders to light therapy...
  14. ncbi request reprint Decreased serotonin 2A receptor densities in neuroleptic-naive patients with schizophrenia: A PET study using [(18)F]setoperone
    E T Ngan
    Department of Psychiatry, University of British Columbia, Vancouver, BC, Canada
    Am J Psychiatry 157:1016-8. 2000
    ..The authors compared serotonin receptor binding in patients with schizophrenia and healthy comparison subjects...
  15. ncbi request reprint Seasonal depression: the dual vulnerability hypothesis revisited
    R W Lam
    Division of Mood Disorders, Department of Psychiatry, University of British Columbia Hospital, Vancouver Hospital and Health Sciences Centre, 2255 Wesbrook Mall, BC, Canada V6T 2A1
    J Affect Disord 63:123-32. 2001
    ..In this study, we compare the clinical characteristics of these three seasonal groups and their response to light therapy...
  16. ncbi request reprint A controlled study of light therapy in women with late luteal phase dysphoric disorder
    R W Lam
    Department of Psychiatry, University of British Columbia, Vancouver Hospital and Health Sciences Centre, Canada
    Psychiatry Res 86:185-92. 1999
    ..These results suggest that bright light therapy is an effective treatment for LLPDD...
  17. ncbi request reprint Effects of alpha-methyl-para-tyrosine-induced catecholamine depletion in patients with seasonal affective disorder in summer remission
    R W Lam
    Division of Mood Disorders, Department of Psychiatry, University of British Columbia, and UBC Hospital, Vancouver Hospital and Health Sciences Centre, Vancouver, B C, Canada
    Neuropsychopharmacology 25:S97-101. 2001
    ..AMPT-induced depressive relapse may be a trait marker for SAD, and/or brain catecholamines may play a direct role in the pathogenesis of SAD...
  18. ncbi request reprint Clinical predictors of short-term outcome in electroconvulsive therapy
    R W Lam
    Department of Psychiatry, University of British Columbia, Vancouver
    Can J Psychiatry 44:158-63. 1999
    ..This study examined ECT use in a university teaching hospital to determine predictors of short-term ECT outcome...
  19. ncbi request reprint An open trial of light therapy for women with seasonal affective disorder and comorbid bulimia nervosa
    R W Lam
    Department of Psychiatry, University of British Columbia, Vancouver, Canada
    J Clin Psychiatry 62:164-8. 2001
    ..Controlled studies of light therapy in SAD and in bulimia nervosa have shown beneficial effects on mood and binge/purge symptoms. We explored the clinical use of light therapy in women with SAD who also had comorbid bulimia nervosa...
  20. doi request reprint The impact of childhood trauma on cognitive functioning in patients recently recovered from a first manic episode: data from the Systematic Treatment Optimization Program for Early Mania (STOP-EM)
    J Bücker
    Department of Psychiatry, University of British Columbia, Vancouver, Canada BC V6T2A1
    J Affect Disord 148:424-30. 2013
    ..In this study, we investigated the impact of childhood trauma on specific cognitive dysfunction in patients who recently recovered from their first episode of mania...
  21. ncbi request reprint Comparative efficacy of typical and atypical antipsychotics as add-on therapy to mood stabilizers in the treatment of acute mania
    D S Miller
    Department of Psychiatry, University of British Columbia, Vancouver, Canada
    J Clin Psychiatry 62:975-80. 2001
    ..atypical antipsychotics are an excellent choice as add-on therapy to mood stabilizers for the treatment of patients with mania...
  22. doi request reprint Decreased mRNA expression of uncoupling protein 2, a mitochondrial proton transporter, in post-mortem prefrontal cortex from patients with bipolar disorder and schizophrenia
    A D Gigante
    Department of Psychiatry, University of British Columbia, Vancouver, Canada
    Neurosci Lett 505:47-51. 2011
    ..Although more studies are necessary, our results suggest that UCP2 is not been used as a compensatory mechanism to oppose the higher levels of oxidative stress found in BD and SCZ...
  23. doi request reprint Relationship between cognitive functioning and 6-month clinical and functional outcome in patients with first manic episode bipolar I disorder
    I J Torres
    Department of Psychiatry, University of British Columbia, Vancouver, BC, Canada
    Psychol Med 41:971-82. 2011
    ..The purpose of this study was to evaluate the impact of cognitive functioning on longitudinal 6-month functional and clinical outcome in recently diagnosed clinically stable patients with bipolar disorder...
  24. ncbi request reprint Risperidone plus lithium versus risperidone plus valproate in acute and continuation treatment of mania
    Lakshmi N Yatham
    University of British Columbia, Vancouver, British Columbia Janssen Ortho Inc, Toronto, Canada
    Int Clin Psychopharmacol 19:103-9. 2004
    ..These data suggest that risperidone can be safely combined with either lithium or valproate, and that the efficacy is similar regardless of the mood stabilizer used...
  25. ncbi request reprint Canadian Network for Mood and Anxiety Treatments (CANMAT) guidelines for the management of patients with bipolar disorder: consensus and controversies
    Lakshmi N Yatham
    Department of Psychiatry, University of British Columbia, Vancouver, BC, Canada
    Bipolar Disord 7:5-69. 2005
    ..These guidelines also discuss issues related to bipolar disorder in women and those with comorbidity and include a section on safety and monitoring...
  26. ncbi request reprint Canadian Network for Mood and Anxiety Treatments (CANMAT) guidelines for the management of patients with bipolar disorder: update 2007
    Lakshmi N Yatham
    Department of Psychiatry, University of British Columbia, 2255 Wesbrook Mall, Vancouver, BC, Canada
    Bipolar Disord 8:721-39. 2006
    ..The importance of comorbid psychiatric and medical conditions cannot be understated, and this update provides an expanded look at the prevalence, impact and management of comorbid conditions in patients with bipolar disorder...
  27. ncbi request reprint Oral methylphenidate fails to elicit significant changes in extracellular putaminal dopamine levels in Parkinson's disease patients: positron emission tomographic studies
    Kaveh M Koochesfahani
    Pacific Parkinson s Research Centre, University of British Columbia, Vancouver, British Columbia, Canada
    Mov Disord 21:970-5. 2006
    ..Our data provide in vivo neurochemical support for the lack of clinical efficacy following MP in PD patients and are also in keeping with reduced DA release following amphetamine in PD subjects...
  28. ncbi request reprint Atypical antipsychotics in bipolar depression: potential mechanisms of action
    Lakshmi N Yatham
    Department of Psychiatry, The University of British Columbia, UBC Hospital, Vancouver, Canada
    J Clin Psychiatry 66:40-8. 2005
    ..Further studies should be conducted to examine these hypotheses...
  29. ncbi request reprint Pharmacotherapy of bipolar II disorder: a critical review of current evidence
    George Hadjipavlou
    Department of Psychiatry, University of British Columbia, Vancouver, Canada
    Bipolar Disord 6:14-25. 2004
    ..To address the growing need to find effective treatment strategies for patients with BP II, this article identifies and summarizes available published evidence specific to the pharmacotherapy of BP II...
  30. ncbi request reprint A magnetic resonance imaging study of mood stabilizer- and neuroleptic-naïve first-episode mania
    Lakshmi N Yatham
    Division of Mood Disorders, University of British Columbia, Vancouver, BC, Canada
    Bipolar Disord 9:693-7. 2007
    ..Studies in first-episode (FE) manic patients have the potential to provide answers to these questions...
  31. ncbi request reprint Risperidone in acute and continuation treatment of mania
    Lakshmi N Yatham
    Department of Psychiatry, University of British Columbia, Vancouver, Canada
    Int Clin Psychopharmacol 18:227-35. 2003
    ..Risperidone add-on does not induce depressive symptoms and, furthermore, risperidone may have efficacy in treating comorbid depressive symptoms in bipolar patients...
  32. ncbi request reprint Bipolar depression: criteria for treatment selection, definition of refractoriness, and treatment options
    Lakshmi N Yatham
    Department of Psychiatry, The University of British Columbia, Vancouver, British Columbia, Canada
    Bipolar Disord 5:85-97. 2003
    ..This paper reviews controlled studies of bipolar depression, outlines criteria for choosing treatment, defines refractoriness in bipolar depression, and provides options for treatment of refractory bipolar depression...
  33. ncbi request reprint A double blind, randomized, placebo-controlled trial of quetiapine as an add-on therapy to lithium or divalproex for the treatment of bipolar mania
    Lakshmi N Yatham
    Division of Mood Disorders, University of British Columbia, UBC Hospital, Vancouver, British Columbia, Canada
    Int Clin Psychopharmacol 22:212-20. 2007
    ..Overall, the combination of quetiapine with lithium or divalproex was well tolerated...
  34. pmc Quality of life in bipolar disorder: a review of the literature
    Erin E Michalak
    Department of Psychiatry, University of British Columbia, Vancouver, Canada
    Health Qual Life Outcomes 3:72. 2005
    ..We identified several important avenues for future research, including a need for more assessment of QoL in hypo/manic patients, more longitudinal research and the development of a disease-specific measure of QoL for patients with BD...
  35. ncbi request reprint A positron emission tomography study of the effects of treatment with valproate on brain 5-HT2A receptors in acute mania
    Lakshmi N Yatham
    Division of Mood Disorders, University of British Columbia, Vancouver, BC, Canada
    Bipolar Disord 7:53-7. 2005
    ..To examine the effects of treatment with valproate on brain 5-HT2A receptors in acute manic patients using positron emission tomography (PET) and [18F]-setoperone...
  36. ncbi request reprint Setting the stage: from prodrome to treatment resistance in bipolar disorder
    Michael Berk
    Barwon Health and The Geelong Clinic, Geelong, Victoria, Australia
    Bipolar Disord 9:671-8. 2007
    ..At the other end of the spectrum, the model attempts to operationalize treatment resistance. The utility of the model will need to be validated by empirical research...
  37. ncbi request reprint Effect of valproate on plasma levels of interleukin-6 in healthy male humans
    I Shin Shiah
    Department of Psychiatry, Tri Service General Hospital, National Defense Medical Center, Taipei, Taiwan
    Int Clin Psychopharmacol 20:295-8. 2005
    ....
  38. ncbi request reprint Polytherapy in bipolar disorder
    Daniel Lin
    Department of Psychiatry, University of British Columbia, Vancouver, Canada
    CNS Drugs 20:29-42. 2006
    ..Similarly, the combination of lithium or valproate plus olanzapine seems to be more effective than monotherapy with a mood stabiliser in preventing manic episodes...
  39. ncbi request reprint Olanzapine versus lithium in the maintenance treatment of bipolar disorder: a 12-month, randomized, double-blind, controlled clinical trial
    Mauricio Tohen
    Lilly Research Laboratories, Indianapolis, IN 46285, USA
    Am J Psychiatry 162:1281-90. 2005
    ..The authors compared the efficacy of olanzapine and lithium in the prevention of mood episode relapse/recurrence...
  40. doi request reprint Emotional memory in bipolar disorder
    Márcia Kauer-Sant'Anna
    Mood Disorders Centre, University of British Columbia, 2C7 2255 Wesbrook Mall, Vancouver, Canada V6T 2A1
    Br J Psychiatry 192:458-63. 2008
    ..Cognitive impairment has been well documented in bipolar disorder. However, specific aspects of cognition such as emotional memory have not been examined...
  41. ncbi request reprint Bipolar disorder and quality of life: a patient-centered perspective
    Erin E Michalak
    Division of Mood Disorders, Department of Psychiatry, University of British Columbia, Vancouver, BC V6T 2A1, Canada
    Qual Life Res 15:25-37. 2006
    ..We report here on a series of in-depth qualitative interviews we conducted as part of the item generation phase for a disease-specific scale to assess QoL in BD...
  42. doi request reprint Depot risperidone in the outpatient management of bipolar disorder: a 2-year study of 10 patients
    Rao N Malempati
    Mood and Anxiety Disorders Program, Hotel Dieu Grace Hospital, Windsor, Ontario, Canada
    Int Clin Psychopharmacol 23:88-94. 2008
    ..Clinicians may consider risperidone Consta as an option in patients with refractory bipolar illness, including those with a predominantly depressive course, and particularly in patients' nonadherence with prescribed medications...
  43. ncbi request reprint The impact of bipolar disorder upon work functioning: a qualitative analysis
    Erin E Michalak
    Division of Mood Disorders, Department of Psychiatry, University of British Columbia, Vancouver, British Columbia, Canada
    Bipolar Disord 9:126-43. 2007
    ..In order to further elucidate the relationship between BD and work, we report here on a series of exploratory qualitative interviews undertaken to develop a disease-specific measure of quality of life in BD...
  44. doi request reprint Diagnostic guidelines for bipolar disorder: a summary of the International Society for Bipolar Disorders Diagnostic Guidelines Task Force Report
    S Nassir Ghaemi
    Bipolar Disorder Research Program, Department of Psychiatry, Emory University, Atlanta, GA 30322, USA
    Bipolar Disord 10:117-28. 2008
    ....
  45. ncbi request reprint Comment on "Antidepressant treatment-emergent switch in bipolar disorder: a prospective case-control study of outcome"
    Márcia Kauer-Sant'Anna
    Rev Bras Psiquiatr 29:86-7; author reply 87-8. 2007
  46. doi request reprint Pure and mixed manic subtypes: a review of diagnostic classification and validation
    Frederick Cassidy
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    Bipolar Disord 10:131-43. 2008
    ..To review issues surrounding the diagnosis and validity of bipolar manic states...
  47. ncbi request reprint Traumatic life events in bipolar disorder: impact on BDNF levels and psychopathology
    Juliana Tramontina
    Post Graduate Biochemistry Program, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil
    Bipolar Disord 9:128-35. 2007
    ....
  48. ncbi request reprint Incidence and time course of subsyndromal symptoms in patients with bipolar I disorder: an evaluation of 2 placebo-controlled maintenance trials
    Mark A Frye
    Mood Disorders Research Program, University of California at Los Angeles, USA
    J Clin Psychiatry 67:1721-8. 2006
    ..Subsyndromal symptoms in bipolar disorder can cause significant functional impairment and are associated with relapse...
  49. ncbi request reprint Translating knowledge of genetics and pharmacology into improving everyday practice
    Lakshmi N Yatham
    Department of Psychiatry, University of British Columbia, Vancouver, BC, Canada
    Bipolar Disord 7:13-20. 2005
    ....
  50. pmc Immediate effects of risperidone on cerebral activity in healthy subjects: a comparison with subjects with first-episode schizophrenia
    Carol J Lane
    Department of Psychiatry, University of British Columbia, Vancouver, BC
    J Psychiatry Neurosci 29:30-7. 2004
    ....
  51. ncbi request reprint Acute and maintenance treatment of bipolar mania: the role of atypical antipsychotics
    Lakshmi N Yatham
    Mood Disorders Clinical Research Unit, The University of British Columbia, Vancouver, BC, V6T 2A1, Canada
    Bipolar Disord 5:7-19. 2003
    ..The atypical antipsychotics represent an effective and relatively safe addition to our armamentarium for the treatment of bipolar disorder...
  52. ncbi request reprint Advances in treatment of mood and anxiety disorders: focus on atypical antipsychotics
    Lakshmi N Yatham
    University of British Columbia, Vancouver, BC
    Bipolar Disord 5:5-6. 2003
  53. ncbi request reprint A placebo-controlled 18-month trial of lamotrigine and lithium maintenance treatment in recently depressed patients with bipolar I disorder
    Joseph R Calabrese
    University Hospitals of Cleveland Case Western Reserve School of Medicine, Department of Psychiatry, 11400 Euclid Ave, Ste 200, Cleveland, OH 44106, USA
    J Clin Psychiatry 64:1013-24. 2003
    ..This study assessed the efficacy and tolerability of lamotrigine and lithium compared with placebo for the prevention of mood episodes in bipolar disorder...
  54. ncbi request reprint Olanzapine versus placebo in acute mania: treatment responses in subgroups
    Ross J Baldessarini
    International Consortium for Bipolar Disorder Research, Department of Psychiatry and Neuroscience Program, Harvard Medical School, Boston, MA, USA
    J Clin Psychopharmacol 23:370-6. 2003
    ..5-1.7, all P < 0.01). These well-powered comparisons of subgroups of interest indicate broad efficacy of olanzapine in the treatment of acute mania...
  55. ncbi request reprint Efficacy of atypical antipsychotics in mood disorders
    Lakshmi N Yatham
    University of British Columbia, Vancouver, Canada
    J Clin Psychopharmacol 23:S9-14. 2003
    ....
  56. ncbi request reprint A placebo-controlled 18-month trial of lamotrigine and lithium maintenance treatment in recently manic or hypomanic patients with bipolar I disorder
    Charles L Bowden
    Department of Psychiatry, University of Texas Health Science Center at San Antonio, 78229, USA
    Arch Gen Psychiatry 60:392-400. 2003
    ....
  57. ncbi request reprint Rates of response, euthymia and remission in two placebo-controlled olanzapine trials for bipolar mania
    K N Roy Chengappa
    Western Psychiatric Institute and Clinic, Mayview State Hospital, University of Pittsburgh Medical Center, PA 15213 2593, USA
    Bipolar Disord 5:1-5. 2003
    ....
  58. ncbi request reprint Mood stabilization and the role of antipsychotics
    Lakshmi N Yatham
    Mood Disorders Clinical Research Unit, Department of Psychiatry, University of British Columbia, Vancouver, Canada
    Int Clin Psychopharmacol 17:S21-7. 2002
    ..This article will review the results from open and double-blind studies with quetiapine, ziprasidone, risperidone and olanzapine in the management of bipolar disorder...
  59. pmc Bipolar spectrum disorders. New perspectives
    Andre Piver
    Nelson Mental Health Centre, Kootenay Lake Regional Hospital, Nelson, BC
    Can Fam Physician 48:896-904. 2002
    ..To review new perspectives on diagnosis, clinical features, epidemiology, and treatment of bipolar II and related disorders...
  60. ncbi request reprint Third generation anticonvulsants in bipolar disorder: a review of efficacy and summary of clinical recommendations
    Lakshmi N Yatham
    Department of Psychiatry, University of British Columbia, Vancouver, Canada
    J Clin Psychiatry 63:275-83. 2002
    ..To review the literature on efficacy of third generation anticonvulsants for treatment of bipolar disorder and provide clinical recommendations...
  61. ncbi request reprint International Consensus Group on Bipolar I Depression Treatment Guidelines
    Joseph R Calabrese
    Department of Psychiatry, Case Western Reserve University, Cleveland, OH, USA
    J Clin Psychiatry 65:571-9. 2004
  62. ncbi request reprint Newer anticonvulsants in the treatment of bipolar disorder
    Lakshmi N Yatham
    Division of Mood Disorders, University of British Columbia, Vancouver, British Columbia, Canada
    J Clin Psychiatry 65:28-35. 2004
    ..This article summarizes current evidence from trials of anticonvulsants in bipolar disorder and makes recommendations for their clinical use...
  63. ncbi request reprint Lamotrigine for bipolar disorder: translating research into clinical practice
    Jonathan Fung
    Department of Psychiatry, University of British Columbia, Vancouver, Canada
    Expert Rev Neurother 4:363-70. 2004
    ..Practical recommendations regarding titration and the management of rash are offered...
  64. ncbi request reprint Atypical antipsychotics for bipolar disorder
    Lakshmi N Yatham
    Mood Disorders Clinical Research Unit, University of British Columbia, Room 2C7 2255 Wesbrook Mall, Vancouver, BC V6T 2A1, Canada
    Psychiatr Clin North Am 28:325-47. 2005
    ..Overall, the atypical antipsychotic agents as a group represent an effective and relatively safe addition to the armamentarium for the treatment of bipolar disorder...
  65. ncbi request reprint Perceived quality of life in patients with bipolar disorder. Does group psychoeducation have an impact?
    Erin E Michalak
    Department of Psychiatry, University of British Columbia, Vancouver
    Can J Psychiatry 50:95-100. 2005
    ..We aimed to assess the impact of a time-limited psychoeducation (PE) group therapy upon perceived QoL among patients with BD...
  66. ncbi request reprint Diagnosis and management of patients with bipolar II disorder
    Lakshmi N Yatham
    Division of Mood Disorders, University of British Columbia, Vancouver, Canada
    J Clin Psychiatry 66:13-7. 2005
    ..Hypomania will likely respond to monotherapy with antimanic agents. Adjunctive psychosocial treatments may provide additional benefit in patients with bipolar II disorder...
  67. ncbi request reprint Bipolar II disorder: an overview of recent developments
    George Hadjipavlou
    Department of Psychiatry, University of British Columbia, Vancouver
    Can J Psychiatry 49:802-12. 2004
    ..Recent research on the epidemiology, clinical course, diagnosis, and treatment of bipolar II disorder (BD II) stands to have a considerable impact on clinical practice. This paper reviews these developments...
  68. ncbi request reprint Recovery and functional outcomes following olanzapine treatment for bipolar I mania
    K N Roy Chengappa
    Western Psychiatric Institute and Clinic, University of Pittsburgh, School of Medicine, Pittsburgh, PA 15213 2593, USA
    Bipolar Disord 7:68-76. 2005
    ..Typical experimental categorizations of treatment responses in bipolar disorder (BPD) patients may have limited relationship to clinical recovery or functional status, and there is inadequate research on such clinically important outcomes...
  69. ncbi request reprint Quetiapine versus placebo in combination with lithium or divalproex for the treatment of bipolar mania
    Lakshmi N Yatham
    Department of Psychiatry, University of British Columbia, Vancouver, BC, Canada
    J Clin Psychopharmacol 24:599-606. 2004
    ..Quetiapine, in combination with lithium or divalproex, is well tolerated and has superior efficacy to lithium or divalproex alone in the treatment of bipolar mania...
  70. ncbi request reprint Comparison of rapid-cycling and non-rapid-cycling bipolar I manic patients during treatment with olanzapine: analysis of pooled data
    Eduard Vieta
    Bipolar Disorders Program, Department of Psychiatry, Hospital Clinic, University of Barcelona, IDIBAPS, Barcelona, Spain
    J Clin Psychiatry 65:1420-8. 2004
    ..We report on the first controlled study comparing acute and continuous clinical outcomes in RC and non-RC manic patients treated with olanzapine...
  71. ncbi request reprint Quality of life in patients with bipolar I depression: data from 920 patients
    Lakshmi N Yatham
    The University of British Columbia, Vancouver, BC, Canada
    Bipolar Disord 6:379-85. 2004
    ..To determine the impact of acute depression on quality of life (QOL) in patients with bipolar I disorder and to compare these results with published data on QOL in patients with unipolar depression...
  72. ncbi request reprint Comorbidity in bipolar disorder: a framework for rational treatment selection
    Roger S McIntyre
    Mood Disorder Psychopharmacology Unit, University of Toronto, University Health Network Toronto Western Hospital, 399 Bathurst Street, Toronto, Ontario M5T 2S9, Canada
    Hum Psychopharmacol 19:369-86. 2004
    ..This schema should be further informed by the treatment data for comorbid and accessory conditions. The authors propose a schema to provide the impetus for further work in the area...
  73. ncbi request reprint Electroretinography in patients with winter seasonal affective disorder
    Marc Hebert
    Department of Ophthalmology, Laval University Medical Research Center CHUQ, Faculty of Medicine, Laval University, Sainte Foy, Quebec, Canada
    Psychiatry Res 127:27-34. 2004
    ..We hypothesize that brain neurotransmitter dysregulation may be at the origin of both the mood disorder and retinal sensitivity change...
  74. ncbi request reprint The role of novel antipsychotics in bipolar disorders
    Lakshmi N Yatham
    Division of Mood Disorders, University of British Columbia, Vancouver, Canada
    J Clin Psychiatry 63:10-4. 2002
    ..Olanzapine, another novel antipsychotic, is also effective against both manic and depressive symptoms and in the maintenance treatment as indicated by an open-label study. Data on other novel agents are more limited...