X Yang

Summary

Affiliation: University of Manitoba
Country: Canada

Publications

  1. pmc CD8+ DC, but Not CD8(-)DC, isolated from BCG-infected mice reduces pathological reactions induced by mycobacterial challenge infection
    Xiaoling Gao
    Laboratory for Infection and Immunity, Department of Medical Microbiology, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada
    PLoS ONE 5:e9281. 2010
  2. pmc IL-17A synergizes with IFN-γ to upregulate iNOS and NO production and inhibit chlamydial growth
    Yongci Zhang
    Department of Immunology, Tianjin Key Laboratory of Cellular and Molecular Immunology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China
    PLoS ONE 7:e39214. 2012
  3. ncbi IL-10 deficiency prevents IL-5 overproduction and eosinophilic inflammation in a murine model of asthma-like reaction
    X Yang
    Immune Regulation of Allergy Research Group, Departments of Medical Microbiology and Immunology, Faculty of Medicine, University of Manitoba, Winnipeg, Canada
    Eur J Immunol 30:382-91. 2000
  4. ncbi Does allergen immunotherapy alter the natural course of allergic disorders?
    X Yang
    Department of Medical Microbiology, Faculty of Medicine, University of Manitoba, Winnipeg, Canada
    Drugs 61:365-74. 2001
  5. ncbi IL-10 gene knockout mice show enhanced Th1-like protective immunity and absent granuloma formation following Chlamydia trachomatis lung infection
    X Yang
    Department of Medical Microbiology, Faculty of Medicine, University of Manitoba, Winnipeg, Canada
    J Immunol 162:1010-7. 1999
  6. pmc Role of dendritic cells: a step forward for the hygiene hypothesis
    Xi Yang
    Laboratory for Infection and Immunity, Department of Medical Microbiology, Faculty of Medicine, University of Manitoba, Winnipeg, MB, Canada
    Cell Mol Immunol 8:12-8. 2011
  7. ncbi Distinct function of Th1 and Th2 type delayed type hypersensitivity: protective and pathological reactions to chlamydial infection
    X Yang
    Laboratory for Infection and Immunity, Department of Medical Microbiology, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada R3E OW3
    Microsc Res Tech 53:273-7. 2001
  8. pmc Mycobacterial infection inhibits established allergic inflammatory responses via alteration of cytokine production and vascular cell adhesion molecule-1 expression
    Xi Yang
    Immune Regulation of Allergy Research Group, Department of Medical Microbiology, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada
    Immunology 105:336-43. 2002
  9. ncbi Gene knockout B cell-deficient mice demonstrate that B cells play an important role in the initiation of T cell responses to Chlamydia trachomatis (mouse pneumonitis) lung infection
    X Yang
    Department of Medical Microbiology, University of Manitoba, Winnipeg, Canada
    J Immunol 161:1439-46. 1998
  10. ncbi Role of cytokines in Chlamydia trachomatis protective immunity and immunopathology
    Xi Yang
    Laboratory for Infection and Immunity, Department of Medical Microbiology, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba, R3E OW3, Canada
    Curr Pharm Des 9:67-73. 2003

Collaborators

Detail Information

Publications54

  1. pmc CD8+ DC, but Not CD8(-)DC, isolated from BCG-infected mice reduces pathological reactions induced by mycobacterial challenge infection
    Xiaoling Gao
    Laboratory for Infection and Immunity, Department of Medical Microbiology, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada
    PLoS ONE 5:e9281. 2010
    ..Type-1 T cell immunity has been shown to be critical for host defence against tuberculosis infection, but the role of dendritic cell (DC) subsets in pathogenesis of mycobacterial infection remains unclear...
  2. pmc IL-17A synergizes with IFN-γ to upregulate iNOS and NO production and inhibit chlamydial growth
    Yongci Zhang
    Department of Immunology, Tianjin Key Laboratory of Cellular and Molecular Immunology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China
    PLoS ONE 7:e39214. 2012
    ..Taken together, the results indicate that IL-17A and IFN-γ play a synergistic role in inhibiting chlamydial lung infection, at least partially through enhancing iNOS expression and NO production in epithelial cells and macrophages...
  3. ncbi IL-10 deficiency prevents IL-5 overproduction and eosinophilic inflammation in a murine model of asthma-like reaction
    X Yang
    Immune Regulation of Allergy Research Group, Departments of Medical Microbiology and Immunology, Faculty of Medicine, University of Manitoba, Winnipeg, Canada
    Eur J Immunol 30:382-91. 2000
    ..The data also argue that IL-10 may be more influential in the development of IL-5-producing Th2 cells which differ from typical Th2 cells producing both IL-4 and IL-5...
  4. ncbi Does allergen immunotherapy alter the natural course of allergic disorders?
    X Yang
    Department of Medical Microbiology, Faculty of Medicine, University of Manitoba, Winnipeg, Canada
    Drugs 61:365-74. 2001
    ....
  5. ncbi IL-10 gene knockout mice show enhanced Th1-like protective immunity and absent granuloma formation following Chlamydia trachomatis lung infection
    X Yang
    Department of Medical Microbiology, Faculty of Medicine, University of Manitoba, Winnipeg, Canada
    J Immunol 162:1010-7. 1999
    ..These results suggest that IL-10 inhibits the priming and expansion of Th1-like T cell responses and that IL-10 plays a role in the fibrotic reaction seen with chlamydial infection...
  6. pmc Role of dendritic cells: a step forward for the hygiene hypothesis
    Xi Yang
    Laboratory for Infection and Immunity, Department of Medical Microbiology, Faculty of Medicine, University of Manitoba, Winnipeg, MB, Canada
    Cell Mol Immunol 8:12-8. 2011
    ....
  7. ncbi Distinct function of Th1 and Th2 type delayed type hypersensitivity: protective and pathological reactions to chlamydial infection
    X Yang
    Laboratory for Infection and Immunity, Department of Medical Microbiology, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada R3E OW3
    Microsc Res Tech 53:273-7. 2001
    ..The functional differences in Th1 and Th2 type DTH responses may account for the dual role DTH plays in chlamydial protective immunity and immunopathology...
  8. pmc Mycobacterial infection inhibits established allergic inflammatory responses via alteration of cytokine production and vascular cell adhesion molecule-1 expression
    Xi Yang
    Immune Regulation of Allergy Research Group, Department of Medical Microbiology, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada
    Immunology 105:336-43. 2002
    ..These findings suggest that intracellular bacterial infection can inhibit established allergic responses via alteration of local cytokine production and the expression of adhesion molecules...
  9. ncbi Gene knockout B cell-deficient mice demonstrate that B cells play an important role in the initiation of T cell responses to Chlamydia trachomatis (mouse pneumonitis) lung infection
    X Yang
    Department of Medical Microbiology, University of Manitoba, Winnipeg, Canada
    J Immunol 161:1439-46. 1998
    ..This study provides evidence for the role of B cells in the in vivo priming of T cells during infection with the intracellular bacterial pathogen, C. trachomatis...
  10. ncbi Role of cytokines in Chlamydia trachomatis protective immunity and immunopathology
    Xi Yang
    Laboratory for Infection and Immunity, Department of Medical Microbiology, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba, R3E OW3, Canada
    Curr Pharm Des 9:67-73. 2003
    ..Further studies should be performed to elucidate the role played by DCs in natural chlamydial infection and the potential involvement of DC subsets in directing immune responses to chlamydial infection...
  11. ncbi Natural killer T (NKT) cell subsets in chlamydial infections
    Xi Yang
    Laboratory for Infection and Immunity, Departments of Medical Microbiology and Immunology, University of Manitoba, Winnipeg, Manitoba, Canada
    Adv Exp Med Biol 601:243-6. 2007
    ..Our study provides in vivo evidence that even closely related pathogens may activate different functional NKT subsets, which can further polarize CD4+ and CD8+ cells in adaptive immune responses...
  12. ncbi IL-12-dependent vascular cell adhesion molecule-1 expression contributes to airway eosinophilic inflammation in a mouse model of asthma-like reaction
    S Wang
    Immune Regulation of Allergy Research Group, Departments of Medical Microbiology and Immunology, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada
    J Immunol 166:2741-9. 2001
    ..The results suggest that endogenous IL-12 contributes to the recruitment of eosinophils into airways observed in asthma, possibly via enhancement of the expression of VCAM-1 on local vascular endothelial cells...
  13. ncbi IFN-gamma knockout mice show Th2-associated delayed-type hypersensitivity and the inflammatory cells fail to localize and control chlamydial infection
    S Wang
    Laboratory for Infection, Department of Medical Microbiology, Faculty of Medicine, University of Manitoba, Winnipeg, Canada
    Eur J Immunol 29:3782-92. 1999
    ..Moreover, the data suggest that the IFN-gamma KO mouse is a useful model system for studying chlamydial pathogenesis...
  14. pmc Different roles are played by alpha beta and gamma delta T cells in acquired immunity to Chlamydia trachomatis pulmonary infection
    X Yang
    Department of Medical Microbiology, University of Manitoba, Winnipeg, Canada
    Immunology 94:469-75. 1998
    ..The data indicate that the alpha beta T cell is the major T-cell population for acquired immunity to chlamydial infection and that gamma delta T cells may play an ancillary role in regulating the magnitude of alpha beta T-cell responses...
  15. ncbi BAG-1 p50 isoform interacts with the vitamin D receptor and its cellular overexpression inhibits the vitamin D pathway
    M Witcher
    Basic Medical Sciences, Faculty of Medicine, Memorial University of Newfoundland, Newfoundland, A1B 3V6, Canada
    Exp Cell Res 265:167-73. 2001
    ..These results suggest that BAG-1 p50 is a novel regulator of the vitamin D signaling pathway, and its overexpression may lead to cellular resistance to 1,25(OH)2D3 therapy...
  16. pmc Autoimmunity to heat shock protein 60 and antigen-specific production of interleukin-10
    Y Yi
    Department of Medical Microbiology, University of Manitoba, Winnipeg, Canada
    Infect Immun 65:1669-74. 1997
    ..Switches in cytokine production patterns may mediate the pathogenesis of hsp60-associated diseases such as C. trachomatis immunopathology...
  17. doi Imprinted DC mediate the immune-educating effect of early-life microbial exposure
    Lei Jiao
    Department of Medical Microbiology and Immunology, Faculty of Medicine, University of Manitoba, Winnipeg, Man, Canada
    Eur J Immunol 39:469-80. 2009
    ..Our study demonstrates a central role of DC in linking the early-life exposure to microbial products and the balanced development of immune regulatory functions and the involvement of T cells in imprinting of the DC function...
  18. pmc Limiting dilution analysis of CD4 T-cell cytokine production in mice administered native versus polymerized ovalbumin: directed induction of T-helper type-1-like activation
    R S Gieni
    Department of Immunology, University of Manitoba, Winnipeg, Canada
    Immunology 87:119-26. 1996
    ....
  19. ncbi Human BAG-1/RAP46 protein is generated as four isoforms by alternative translation initiation and overexpressed in cancer cells
    X Yang
    Basic Medical Sciences, Faculty of Medicine, Memorial University of Newfoundland, St John s, Canada
    Oncogene 17:981-9. 1998
    ....
  20. ncbi Chlamydia trachomatis infection inhibits airway eosinophilic inflammation induced by ragweed
    Laura Bilenki
    Immune Regulation of Allergy Research Group, University of Manitoba, Winnipeg, Manitoba R3E 0W3, Canada
    Clin Immunol 102:28-36. 2002
    ..These data provide evidence that the suppression of the allergic airway inflammation induced by a common environmental allergen is attainable through intracellular bacterial infection...
  21. ncbi Chlamydia infection induces ICOS ligand-expressing and IL-10-producing dendritic cells that can inhibit airway inflammation and mucus overproduction elicited by allergen challenge in BALB/c mice
    Xiaobing Han
    Immune Regulation of Allergy Research Group, Departments of Medical Microbiology and Immunology, Faculty of Medicine, University of Manitoba, 730 William Avenue, Winnipeg, Manitoba, Canada
    J Immunol 176:5232-9. 2006
    ..Overall, the data demonstrate a critical role played by ICOS-L-expressing and IL-10-producing DCs from Chlamydia-infected mice in the infection-mediated inhibition of allergic responses...
  22. ncbi NK T cell activation promotes Chlamydia trachomatis infection in vivo
    Laura Bilenki
    Laboratory for Infection and Immunity, Department of Immunology, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada
    J Immunol 175:3197-206. 2005
    ..These data provide in vivo evidence for the involvement of NKT in a bacterial pathogenesis and its role in promoting Th2 responses during infection...
  23. ncbi NK cells contribute to intracellular bacterial infection-mediated inhibition of allergic responses
    Xiaobing Han
    Immune Regulation of Allergy Research Group, Departments of Medical Microbiology and Immunology, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada
    J Immunol 180:4621-8. 2008
    ..The data suggest that the innate immune cells such as NK cells may play an important role in infection-mediated inhibition of allergic responses...
  24. pmc Less inhibition of interferon-gamma to organism growth in host cells may contribute to the high susceptibility of C3H mice to Chlamydia trachomatis lung infection
    Hongyu Qiu
    Department of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada
    Immunology 111:453-61. 2004
    ..The data suggest that the cellular events downstream of cytokine production in chlamydia host cells may be important in determining the different susceptibility of hosts to chlamydial infection...
  25. pmc Induction of p16 during immortalization by HPV 16 and 18 and not during malignant transformation
    Y Nakao
    Division of Basic Medical Sciences, Faculty of Medicine, Memorial University of Newfoundland, St John s, Canada
    Br J Cancer 75:1410-6. 1997
    ..Also suggested is that p16 has no role in the specific malignant transformation step from immortal premalignant lesions during the carcinogenesis of HPV-initiated cervical cancers...
  26. doi Dendritic cells from mycobacteria-infected mice inhibits established allergic airway inflammatory responses to ragweed via IL-10- and IL-12-secreting mechanisms
    Laura Bilenki
    Immune Regulation of Allergy Research Group, Department of Medical Microbiology, Winnipeg, Mantioba, Canada
    J Immunol 184:7288-96. 2010
    ..These findings suggest that DCs play a crucial role in infection-mediated inhibition of established allergic responses, and IL-10 and IL-12 production by these DCs may be a major mechanism for the inhibition...
  27. doi Natural killer T cells are critical for dendritic cells to induce immunity in Chlamydial pneumonia
    Antony George Joyee
    Laboratory for Infection and Immunity, Department of Medical Microbiology, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada
    Am J Respir Crit Care Med 178:745-56. 2008
    ..We previously showed an important role of natural killer T cells (NKT) in skewing the adaptive T cell immunity to Chlamydia pneumoniae (Cpn), an intracellular bacterial lung infection, but the mechanism remains unclear...
  28. doi Adoptive transfer of dendritic cells isolated from helminth-infected mice enhanced T regulatory cell responses in airway allergic inflammation
    J Y Liu
    Laboratory of Cellular and Molecular Immunology, Department of Parasitology, Faculty of Basic Medicine Sciences, Tianjin Medical University, Tianjin, China
    Parasite Immunol 33:525-34. 2011
    ..These data suggest that helminth infection may induce tolerogenic DCs that can inhibit the development of airway allergic inflammation through enhancing T regulatory cell responses...
  29. ncbi A simple, sensitive, dual mAb based ELISA for murine gamma interferon determination: comparison with two common bioassays
    X Yang
    Department of Immunology, University of Manitoba, Winnipeg, Canada
    J Immunoassay 14:129-48. 1993
    ....
  30. ncbi Cloning and characterization of the human BAG-1 gene promoter: upregulation by tumor-derived p53 mutants
    X Yang
    Division of Basic Medical Sciences, Faculty of Medicine, Memorial University of Newfoundland, 300 Prince Philip Drive, St John s, Newfoundland, Canada, A1B 3V6
    Oncogene 18:4546-53. 1999
    ..These results indicated that we have isolated the functional constitutive BAG-1 promoter. Furthermore, the data suggested that overexpression of BAG-1 in some tumors may be due to upregulation of the human BAG-1 promoter by mutant p53...
  31. ncbi Dendritic cells from Chlamydia-infected mice show altered Toll-like receptor expression and play a crucial role in inhibition of allergic responses to ovalbumin
    Xiaobing Han
    Department of Medical Microbiology, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada
    Eur J Immunol 34:981-9. 2004
    ..The data demonstrate a critical role played by DC in infection-mediated inhibition of allergic responses...
  32. doi IL-17/Th17 promotes type 1 T cell immunity against pulmonary intracellular bacterial infection through modulating dendritic cell function
    Hong Bai
    Laboratory for Infection and Immunity, Departments of Medical Microbiology and Immunology, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada
    J Immunol 183:5886-95. 2009
    ..These findings provide in vivo evidence that IL-17/Th17 plays an important role in host defense against intracellular bacterial infection, and suggest that IL-17/Th17 can promote type 1 T cell immunity through modulating DC function...
  33. doi Invariant NKT cells preferentially modulate the function of CD8 alpha+ dendritic cell subset in inducing type 1 immunity against infection
    Antony George Joyee
    Department of Medical Microbiology, Laboratory for Infection and Immunity, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada
    J Immunol 184:2095-106. 2010
    ..Our data provide the first direct evidence that iNKTs preferentially promote the functional development of a subset of DC to generate protective immunity against infections...
  34. doi Th1 cytokine responses fail to effectively control Chlamydia lung infection in ICOS ligand knockout mice
    Kamran Kadkhoda
    Laboratory for Infection and Immunity, Department of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada
    J Immunol 184:3780-8. 2010
    ....
  35. ncbi Natural killer T cells contribute to airway eosinophilic inflammation induced by ragweed through enhanced IL-4 and eotaxin production
    Laura Bilenki
    Department of Immunology, Immune Regulation of Allergy Research Group, Faculty of Medicine, University of Manitoba, Winnipeg, Canada
    Eur J Immunol 34:345-54. 2004
    ..These data provide in vivo evidence for the involvement of NKT cells in the allergic mechanisms responsible for allergen-driven cytokine and chemokine production and airway inflammation...
  36. ncbi Adoptive transfer of CD8alpha+ dendritic cells (DC) isolated from mice infected with Chlamydia muridarum are more potent in inducing protective immunity than CD8alpha- DC
    Laura Bilenki
    Laboratory for Infection and Immunity, Departments of Immunology and Medical Microbiology, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada
    J Immunol 177:7067-75. 2006
    ..trachomatis infection...
  37. pmc Resistance to chlamydial lung infection is dependent on major histocompatibility complex as well as non-major histocompatibility complex determinants
    Hongyu Qiu
    Department of Medical Microbiology, University of Manitoba, Winnipeg, Canada
    Immunology 116:499-506. 2005
    ..Overall, the results suggest that protection against chlamydial lung infection is both MHC and non-MHC gene dependent, and that the interaction between MHC and non-MHC elements may contribute to host resistance to chlamydial infection...
  38. ncbi Role of toll-like receptors in immune responses to chlamydial infections
    A G Joyee
    Laboratory for Infection and Immunity, Department of Medical Microbiology, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada R3E 0W3
    Curr Pharm Des 14:593-600. 2008
    ....
  39. doi Dynamic proteome analysis of spinal cord injury after ischemia-reperfusion in rabbits by two-dimensional difference gel electrophoresis
    B Zhu
    Department of Orthopedics, the Fifth Central Hospital of Tianjin, Tianjin, China
    Spinal Cord 51:610-5. 2013
    ..Spinal cord injury (SCI) is a devastating and common neurologic disorder that has profound influences on modern society from physical, psychosocial and socio-economic perspectives...
  40. ncbi Response of early-weaned pigs to an enterotoxigenic Escherichia coli (K88) challenge when fed diets containing spray-dried porcine plasma or pea protein isolate plus egg yolk antibody
    A Owusu-Asiedu
    Department of Animal Science, University of Manitoba, Winnipeg, MB, Canada R3T 2N2
    J Anim Sci 81:1781-9. 2003
    ..It was concluded that specific EYA and SDPP could provide passive control of ETEC infection and potentially improve feed intake and weight gain in young pigs fed PPI...
  41. doi Manganese-enhanced MRI of acute cardiac ischemia and chronic infarction in pig hearts: kinetic analysis of enhancement development
    Y Yang
    Institute for Biodiagnostics, National Research Council, Winnipeg, MB, Canada
    NMR Biomed 22:165-73. 2009
    ....
  42. ncbi Molecular cloning of human er1 cDNA and its differential expression in breast tumours and tumour-derived cell lines
    G D Paterno
    Terry Fox Cancer Research Laboratories, Division of Basic Medical Sciences, Faculty of Medicine, Memorial University of Newfoundland, St John s, Newfoundland, Canada
    Gene 222:77-82. 1998
    ..These data suggest that er1 expression is associated with the neoplastic state in human breast carcinoma...
  43. ncbi Novel recombinant interleukin-13 peptide-based vaccine reduces airway allergic inflammatory responses in mice
    Yanbing Ma
    Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, Manitoba, Canada
    Am J Respir Crit Care Med 176:439-45. 2007
    ....
  44. ncbi Type I IFNs enhance susceptibility to Chlamydia muridarum lung infection by enhancing apoptosis of local macrophages
    Hongyu Qiu
    Department of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada
    J Immunol 181:2092-102. 2008
    ..muridarum, confirming the importance of macrophages. Overall, the data indicate that IFNIs play a promoting role in C. muridarum lung infection, largely through increase of local macrophage apoptosis...
  45. ncbi Overexpression of the hyaluronan receptor RHAMM is transforming and is also required for H-ras transformation
    C L Hall
    Manitoba Institute of Cell Biology, University of Manitoba, Winnipeg, Canada
    Cell 82:19-26. 1995
    ....
  46. ncbi Distinct NKT cell subsets are induced by different Chlamydia species leading to differential adaptive immunity and host resistance to the infections
    Antony George Joyee
    Laboratory for Infection and Immunity, Departments of Medical Microbiology and Immunology, Faculty of Medicine, University of Manitoba, 730 William Avenue, Winnipeg, Manitoba, Canada
    J Immunol 178:1048-58. 2007
    ..These results suggest that distinct NKT subsets are induced by even biologically closely related pathogens, thus leading to differential adaptive immune response and infection outcomes...
  47. ncbi Lymphotoxin alpha beta 2 (membrane lymphotoxin) is critically important for resistance to Leishmania major infection in mice
    Guilian Xu
    Department of Immunology, University of Manitoba, Winnipeg, Canada
    J Immunol 179:5358-66. 2007
    ..These results suggest that membrane lymphotoxin plays critical role in resistance to L. major by promoting effective T cell-mediated anti-Leishmania immunity...
  48. ncbi A GABAergic system in airway epithelium is essential for mucus overproduction in asthma
    Yun Yan Xiang
    Sunnybrook Health Sciences Centre, 2075 Bayview Avenue, Toronto, Ontario M4N 3M5, Canada
    Nat Med 13:862-7. 2007
    ..These findings show that a previously unknown epithelial GABAergic system has an essential role in asthma...
  49. pmc Intranasal inoculation of Chlamydia trachomatis mouse pneumonitis agent induces significant neutrophil infiltration which is not efficient in controlling the infection in mice
    Hong Bai
    Department of Immunology, Peking University Health Sciences Centre, Beijing, China
    Immunology 114:246-54. 2005
    ..These results suggest that neutrophils are not efficient for controlling chlamydial lung infection...
  50. ncbi Codon usage bias in Chlamydia trachomatis and the effect of codon modification in the MOMP gene on immune responses to vaccination
    Yan Zheng
    Department of Medical Microbiology, School of Medicine, Shandong University, Jinan, Shandong 250012, PR China
    Biochem Cell Biol 85:218-26. 2007
    ..Taken together, the data show that human-optimized codon optimization can significantly enhance the gene expression and immunogenicity of the C. trachomatis MOMP DNA vaccine...
  51. ncbi Tigogenin inhibits adipocytic differentiation and induces osteoblastic differentiation in mouse bone marrow stromal cells
    Hua Zhou
    Life Science Division, Graduate School at Shenzhen, Tsinghua University, Shenzhen 518055, PR China
    Mol Cell Endocrinol 270:17-22. 2007
    ....
  52. ncbi Macrostemonoside A promotes visfatin expression in 3T3-L1 cells
    Hua Zhou
    Life Science Division, Graduate School at Shenzhen, Tsinghua University, Shenzhen, China
    Biol Pharm Bull 30:279-83. 2007
    ..Its regulation on visfatin in adipocytes may constitute an important element in its improvement of insulin resistance and diabetes...
  53. ncbi The C terminus of MINT forms homodimers and abrogates MINT-mediated transcriptional repression
    Junlin Li
    Department of Medical Genetics and Developmental Biology, State Key Laboratory of GI Cancer Biology, Fourth Military Medical University, Xian 710032, China
    Biochim Biophys Acta 1729:50-6. 2005
    ..These results suggest that MINT may form a dimer or multimer in cells through its C terminus, and that the C terminal fragment of MINT may work as its dominant-negative version...
  54. ncbi Mint represses transactivation of the type II collagen gene enhancer through interaction with alpha A-crystallin-binding protein 1
    Xi Yang
    Department of Medical Genetics and Developmental Biology, State Key Laboratory of Cancer Biology, Fourth Military Medical University, Xian 710032, China
    J Biol Chem 280:18710-6. 2005
    ..The present study shows that MINT is involved in CRYBP1-mediated Col2a1 gene repression and may play a role in regulation of cartilage development...