W Xiao

Summary

Affiliation: University of Saskatchewan
Country: Canada

Publications

  1. ncbi REV3 is required for spontaneous but not methylation damage-induced mutagenesis of Saccharomyces cerevisiae cells lacking O6-methylguanine DNA methyltransferase
    W Xiao
    Department of Microbiology and Immunology, University of Saskatchewan, Saskatoon, Canada
    Mutat Res 431:155-65. 1999
  2. ncbi Genetic interactions between error-prone and error-free postreplication repair pathways in Saccharomyces cerevisiae
    W Xiao
    Department of Microbiology and Immunology, University of Saskatchewan, Saskatoon, Canada
    Mutat Res 435:1-11. 1999
  3. ncbi The Saccharomyces cerevisiae RAD6 group is composed of an error-prone and two error-free postreplication repair pathways
    W Xiao
    Department of Microbiology and Immunology, University of Saskatchewan, Saskatoon, Saskatchewan, S7N 5E5 Canada
    Genetics 155:1633-41. 2000
  4. ncbi Mms4, a putative transcriptional (co)activator, protects Saccharomyces cerevisiae cells from endogenous and environmental DNA damage
    W Xiao
    Department of Microbiology, University of Saskatchewan, Saskatoon, Canada
    Mol Gen Genet 257:614-23. 1998
  5. ncbi Identification, chromosomal mapping and tissue-specific expression of hREV3 encoding a putative human DNA polymerase zeta
    W Xiao
    Department of Microbiology, University of Saskatchewan, Saskatoon, Canada
    Carcinogenesis 19:945-9. 1998
  6. ncbi Deletion of the MAG1 DNA glycosylase gene suppresses alkylation-induced killing and mutagenesis in yeast cells lacking AP endonucleases
    W Xiao
    Department of Microbiology and Immunology, University of Saskatchewan, Saskatoon, Saskatchewan, Canada S7N 5E5
    Mutat Res 487:137-47. 2001
  7. ncbi MMS2, encoding a ubiquitin-conjugating-enzyme-like protein, is a member of the yeast error-free postreplication repair pathway
    S Broomfield
    Department of Microbiology, University of Saskatchewan, 107 Wiggins Road, Saskatoon, SK Canada S7N 5E5
    Proc Natl Acad Sci U S A 95:5678-83. 1998
  8. ncbi UBC13, a DNA-damage-inducible gene, is a member of the error-free postreplication repair pathway in Saccharomyces cerevisiae
    J Brusky
    Department of Microbiology and Immunology, University of Saskatchewan, Saskatoon, Canada
    Curr Genet 37:168-74. 2000
  9. ncbi DNA postreplication repair and mutagenesis in Saccharomyces cerevisiae
    S Broomfield
    Department of Microbiology and Immunology, University of Saskatchewan, 107 Wiggins Road, SK, S7N 5E5, Saskatoon, Canada
    Mutat Res 486:167-84. 2001
  10. ncbi MMS1 protects against replication-dependent DNA damage in Saccharomyces cerevisiae
    T Hryciw
    Department of Microbiology and Immunology, University of Saskatchewan, Saskatoon, SK, Canada, S7K 0M7
    Mol Genet Genomics 266:848-57. 2002

Collaborators

Detail Information

Publications32

  1. ncbi REV3 is required for spontaneous but not methylation damage-induced mutagenesis of Saccharomyces cerevisiae cells lacking O6-methylguanine DNA methyltransferase
    W Xiao
    Department of Microbiology and Immunology, University of Saskatchewan, Saskatoon, Canada
    Mutat Res 431:155-65. 1999
    ..However, the rev3 deletion does not affect methylation damage-induced killing and mutagenesis of the mgt1 mutant, suggesting that endogenous alkyl lesions may be different from O6-MeG...
  2. ncbi Genetic interactions between error-prone and error-free postreplication repair pathways in Saccharomyces cerevisiae
    W Xiao
    Department of Microbiology and Immunology, University of Saskatchewan, Saskatoon, Canada
    Mutat Res 435:1-11. 1999
    ....
  3. ncbi The Saccharomyces cerevisiae RAD6 group is composed of an error-prone and two error-free postreplication repair pathways
    W Xiao
    Department of Microbiology and Immunology, University of Saskatchewan, Saskatoon, Saskatchewan, S7N 5E5 Canada
    Genetics 155:1633-41. 2000
    ..In view of the high degree of sequence conservation of the RAD6 pathway genes among all eukaryotes, the model presented in this study may also apply to mammalian cells and predicts links to human diseases...
  4. ncbi Mms4, a putative transcriptional (co)activator, protects Saccharomyces cerevisiae cells from endogenous and environmental DNA damage
    W Xiao
    Department of Microbiology, University of Saskatchewan, Saskatoon, Canada
    Mol Gen Genet 257:614-23. 1998
    ..These results collectively suggest that Mms4 may function as a transcriptional (co)activator and play an important role in DNA repair and/or synthesis...
  5. ncbi Identification, chromosomal mapping and tissue-specific expression of hREV3 encoding a putative human DNA polymerase zeta
    W Xiao
    Department of Microbiology, University of Saskatchewan, Saskatoon, Canada
    Carcinogenesis 19:945-9. 1998
    ..In light of recent reports of a putative mouse REV3, these results indicate that mammalian cells may also contain a mutagenic pathway which aids in cell survival at the cost of increased mutation...
  6. ncbi Deletion of the MAG1 DNA glycosylase gene suppresses alkylation-induced killing and mutagenesis in yeast cells lacking AP endonucleases
    W Xiao
    Department of Microbiology and Immunology, University of Saskatchewan, Saskatoon, Saskatchewan, Canada S7N 5E5
    Mutat Res 487:137-47. 2001
    ..These results allow us to delineate base lesion flow within the BER pathway and link AP sites to other DNA damage repair and tolerance pathways...
  7. ncbi MMS2, encoding a ubiquitin-conjugating-enzyme-like protein, is a member of the yeast error-free postreplication repair pathway
    S Broomfield
    Department of Microbiology, University of Saskatchewan, 107 Wiggins Road, Saskatoon, SK Canada S7N 5E5
    Proc Natl Acad Sci U S A 95:5678-83. 1998
    ....
  8. ncbi UBC13, a DNA-damage-inducible gene, is a member of the error-free postreplication repair pathway in Saccharomyces cerevisiae
    J Brusky
    Department of Microbiology and Immunology, University of Saskatchewan, Saskatoon, Canada
    Curr Genet 37:168-74. 2000
    ..The involvement of UBC13 in cellular tolerance to DNA-damage is further implicated by our finding that the UBC13 transcript level is increased up to 6-fold in response to DNA-damage...
  9. ncbi DNA postreplication repair and mutagenesis in Saccharomyces cerevisiae
    S Broomfield
    Department of Microbiology and Immunology, University of Saskatchewan, 107 Wiggins Road, SK, S7N 5E5, Saskatoon, Canada
    Mutat Res 486:167-84. 2001
    ..Recombination and PRR are also genetically regulated by a DNA helicase and are coupled to the cell-cycle. The PRR processes appear to be highly conserved within eukaryotes, from yeast to human...
  10. ncbi MMS1 protects against replication-dependent DNA damage in Saccharomyces cerevisiae
    T Hryciw
    Department of Microbiology and Immunology, University of Saskatchewan, Saskatoon, SK, Canada, S7K 0M7
    Mol Genet Genomics 266:848-57. 2002
    ..Together these results suggest a role for an Mms1-dependent, Rad52-mediated, pathway in protecting cells against replication-dependent DNA damage...
  11. ncbi The repair of DNA methylation damage in Saccharomyces cerevisiae
    W Xiao
    Department of Microbiology, University of Saskatchewan, Saskatoon, SK, S7N 5E5, Canada
    Curr Genet 30:461-8. 1996
    ..Based on the above analyses, we discuss possible mechanisms for the repair of methylation damage by various pathways...
  12. ncbi Differential regulation of two closely clustered yeast genes, MAG1 and DDI1, by cell-cycle checkpoints
    Y Zhu
    Department of Microbiology and Immunology, University of Saskatchewan, 107 Wiggins Road, Saskatoon, SK S7N 5E5, Canada
    Nucleic Acids Res 26:5402-8. 1998
    ..Based on this and previous studies, we present two models for the role of checkpoint genes in transcriptional regulation in response to DNA damage...
  13. ncbi The Saccharomyces cerevisiae mre11(ts) allele confers a separation of DNA repair and telomere maintenance functions
    M Chamankhah
    Department of Microbiology and Immunology, University of Saskatchewan, Saskatoon, Canada
    Genetics 155:569-76. 2000
    ..This result provides additional evidence on possible involvement of distinctive mechanisms in DNA repair and telomere maintenance by the Mre11-Rad50-Xrs2 complex...
  14. ncbi Two alternative cell cycle checkpoint pathways differentially control DNA damage-dependent induction of MAG1 and DDI1 expression in yeast
    Y Zhu
    Department of Microbiology and Immunology, University of Saskatchewan, 107 Wiggins Road, Saskatoon, SK S7N 5E5, Canada
    Mol Genet Genomics 266:436-44. 2001
    ..Based on these and previous studies, we present a model for the role of checkpoint genes in transcriptional regulation in response to DNA damage...
  15. ncbi Formation of the yeast Mre11-Rad50-Xrs2 complex is correlated with DNA repair and telomere maintenance
    M Chamankhah
    Department of Microbiology and Immunology, University of Saskatchewan, 107 Wiggins Road, Saskatoon, SK S7N 5E5, Canada
    Nucleic Acids Res 27:2072-9. 1999
    ..Together, these results support and extend a current model regarding Mre11 structure and functions in mitosis and meiosis...
  16. ncbi Molecular cloning and functional characterization of two murine cDNAs which encode Ubc variants involved in DNA repair and mutagenesis
    J Franko
    Department of Microbiology and Immunology, University of Saskatchewan, 107 Wiggins Road, Saskatoon, SK, Canada S7N 5E5
    Biochim Biophys Acta 1519:70-7. 2001
    ..We propose several hypotheses to reconcile the seemingly contradictory observations regarding roles of the two mammalian Mms2 homologs in tumorigenesis and carcinogenesis...
  17. ncbi Isolation of hMRE11B: failure to complement yeast mre11 defects due to species-specific protein interactions
    M Chamankhah
    Department of Microbiology, University of Saskatchewan, 107 Wiggins Road, Saskatoon SK S7N 5E5, Canada
    Gene 225:107-16. 1998
    ..Instead, we propose that the C-terminus of hMre11B participates in protein-protein interaction and functions in a species-specific manner...
  18. ncbi Synergism between yeast nucleotide and base excision repair pathways in the protection against DNA methylation damage
    W Xiao
    Department of Microbiology, University of Saskatchewan, 107 Wiggins Road, Saskatoon, Canada S7N 5E5
    Curr Genet 33:92-9. 1998
    ..Thus, the recombination repair defects of rad1 and rad10 may confer an additional synergistic effect when combined with the apn1 mutation...
  19. ncbi The products of the yeast MMS2 and two human homologs (hMMS2 and CROC-1) define a structurally and functionally conserved Ubc-like protein family
    W Xiao
    Department of Microbiology, University of Saskatchewan, Saskatoon, SK S7N 5E5, Canada
    Nucleic Acids Res 26:3908-14. 1998
    ..We propose that either these proteins function in a common cellular process, such as DNA repair, or they exert their diverse biological roles through a similar biochemical interaction relative to ubiquitination...
  20. ncbi Improving synthetic lethal screens by regulating the yeast centromere sequence
    L Barbour
    Department of Microbiology and Immunology, University of Saskatchewan, Saskatoon, Canada
    Genome 43:910-7. 2000
    ....
  21. ncbi Involvement of homologous recombination repair after proton-induced DNA damage
    C Rostek
    Department of Anatomy and Cell Biology, College of Medicine, University of Saskatchewan, B313 Health Sciences Building, 107 Wiggins Road, Saskatoon, SK S7N 5E5, Canada
    Mutagenesis 23:119-29. 2008
    ..A genetic analysis indicated that increased stress resistance is most likely due to a second-site mutation that suppresses the rad52delta phenotype. We will discuss possible origins of these second-site mutations...
  22. ncbi UBP5 encodes a putative yeast ubiquitin-specific protease that is related to the human Tre-2 oncogene product
    W Xiao
    Department of Microbiology, University of Saskatchewan, Saskatoon, Canada
    Yeast 10:1497-502. 1994
    ..However, disruption of the UBP5 gene in a haploid strain did not result in a noticeable phenotypic alteration...
  23. ncbi Noncovalent interaction between ubiquitin and the human DNA repair protein Mms2 is required for Ubc13-mediated polyubiquitination
    S McKenna
    Department of Biochemistry, University of Alberta, Edmonton, Alberta T6G 2H7, Canada
    J Biol Chem 276:40120-6. 2001
    ....
  24. ncbi Crystal structure of the human ubiquitin conjugating enzyme complex, hMms2-hUbc13
    T F Moraes
    Department of Biochemistry, University of Alberta, Edmonton, Alberta, T6G 2H7, Canada
    Nat Struct Biol 8:669-73. 2001
    ..The structure of the hMms2-hUbc13 complex provides the conceptual foundation for understanding the mechanism of Lys 63 multiubiquitin chain assembly and for its interactions with the RING finger proteins Rad5 and Traf6...
  25. ncbi RNase-L-dependent destabilization of interferon-induced mRNAs. A role for the 2-5A system in attenuation of the interferon response
    X L Li
    Greenebaum Cancer Center, Program in Oncology, University of Maryland, Baltimore, Maryland 21201, USA
    J Biol Chem 275:8880-8. 2000
    ..ISG15 mRNA also displayed RNase-L-dependent regulation. These findings identify a novel role for the 2-5A system in the attenuation of the interferon response...
  26. ncbi Up-regulation of CIR1/CROC1 expression upon cell immortalization and in tumor-derived human cell lines
    L Ma
    Department of Pathology, McMaster University, Hamilton, Ontario, Canada
    Oncogene 17:1321-6. 1998
    ..These results are compatible with induction of CIR1/CROC1 being an early event in the acquisition of immortality and with a role for this gene in the immortal phenotype of tumor cells...
  27. ncbi Primary sequence and biological functions of a Saccharomyces cerevisiae O6-methylguanine/O4-methylthymine DNA repair methyltransferase gene
    W Xiao
    Laboratory of Toxicology, Harvard School of Public Health, Boston, MA 02115
    EMBO J 10:2179-86. 1991
    ..Expression of the MGT1 gene in E.coli prevented the induction by alkylating agents of both G:C to A:T and A:T to G:C transition mutations indicating that this eukaryotic MTase repairs both O6MeG and O4MeT in vivo...
  28. ncbi The Saccharomyces cerevisiae MGT1 DNA repair methyltransferase gene: its promoter and entire coding sequence, regulation and in vivo biological functions
    W Xiao
    Department of Molecular and Cellular Toxicology, Harvard School of Public Health, Boston, MA 02115
    Nucleic Acids Res 20:3599-606. 1992
    ....
  29. ncbi Activation of estrogen receptor blocks interleukin-6-inducible cell growth of human multiple myeloma involving molecular cross-talk between estrogen receptor and STAT3 mediated by co-regulator PIAS3
    L h Wang
    Intramural Research Support Program, Science Applications International Corporation, National Cancer Institute, Frederick, Maryland 21702, USA
    J Biol Chem 276:31839-44. 2001
    ....
  30. ncbi The synaptic SNARE complex is a parallel four-stranded helical bundle
    M A Poirier
    Department of Molecular and Cell Biology, University of California, Berkeley 94720, USA
    Nat Struct Biol 5:765-9. 1998
    ..Based on these findings, we propose a parallel four-stranded coiled coil model for the structure of the synaptic SNARE complex...
  31. ncbi A single adeno-associated virus (AAV)-murine factor VIII vector partially corrects the hemophilia A phenotype
    R Sarkar
    Department of Genetics, University of Pennsylvania, School of Medicine, Philadelphia 19104-6145, USA
    J Thromb Haemost 1:220-6. 2003
    ..Although the parents harbored the transgene in liver, spleen, and gonads, none of the 34 offspring was positive for the transgene, suggesting that the risk of inadvertent germline transmission is low...
  32. ncbi U19/Eaf2 knockout causes lung adenocarcinoma, B-cell lymphoma, hepatocellular carcinoma and prostatic intraepithelial neoplasia
    W Xiao
    Department of Urology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA
    Oncogene 27:1536-44. 2008
    ..The U19/Eaf2 knockout mouse also provides a unique animal model for three important cancers: lung adenocarcinoma, B-cell lymphoma and hepatocellular carcinoma...