W Xiao


Affiliation: University of Saskatchewan
Country: Canada


  1. Xu X, Blackwell S, Lin A, Li F, Qin Z, Xiao W. Error-free DNA-damage tolerance in Saccharomyces cerevisiae. Mutat Res Rev Mutat Res. 2015;764:43-50 pubmed publisher
    ..This review summarizes recent advances in our understanding of error-free DDT and its interplay with Srs2 and homologous recombination. ..
  2. Bai Z, Li Z, Xiao W. Drosophila bendless catalyzes K63-linked polyubiquitination and is involved in the response to DNA damage. Mutat Res. 2018;808:39-47 pubmed publisher
    ..Collectively, our observations imply that Ben-DmUev1a-promoted K63-linked polyubiquitination and involvement in DNA-damage response are highly conserved in eukaryotes including flies. ..
  3. Zang Y, Wang Q, Xue C, Li M, Wen R, Xiao W. Rice UBC13, a candidate housekeeping gene, is required for K63-linked polyubiquitination and tolerance to DNA damage. Rice (N Y). 2012;5:24 pubmed publisher
    ..In addition, OsUBC13 is constitutively expressed at a high level even under various stress conditions, suggesting that it is a housekeeping gene. ..
  4. request reprint
    Xiao W, Chow B, Hanna M, Doetsch P. Deletion of the MAG1 DNA glycosylase gene suppresses alkylation-induced killing and mutagenesis in yeast cells lacking AP endonucleases. Mutat Res. 2001;487:137-47 pubmed
    ..These results allow us to delineate base lesion flow within the BER pathway and link AP sites to other DNA damage repair and tolerance pathways. ..
  5. Ball L, Xu X, Blackwell S, Hanna M, Lambrecht A, Xiao W. The Rad5 helicase activity is dispensable for error-free DNA post-replication repair. DNA Repair (Amst). 2014;16:74-83 pubmed publisher
    ..Since the helicase domain overlaps with the SWI/SNF chromatin-remodelling domain, our findings suggest a structural role of this domain and that the Rad5 helicase activity is dispensable for error-free lesion bypass. ..
  6. Xue C, Liang K, Liu Z, Wen R, Xiao W. Similarities and differences between Arabidopsis PCNA1 and PCNA2 in complementing the yeast DNA damage tolerance defect. DNA Repair (Amst). 2015;28:28-36 pubmed publisher
    ..Collectively, it is concluded that the two AtPCNAs differ in their efficiency for ubiquitination and sumoylation, leading to their differential responses to DNA damage in yeast cells. ..
  7. Li J, Biss M, Fu Y, Xu X, Moore S, Xiao W. Two duplicated genes DDI2 and DDI3 in budding yeast encode a cyanamide hydratase and are induced by cyanamide. J Biol Chem. 2015;290:12664-75 pubmed publisher
    ..Despite the physiological relevance of the cyanamide induction, DDI2/3 is not involved in its own transcriptional regulation. The significance of cyanamide hydratase activity and its induced expression is discussed. ..
  8. Xu X, Lin A, Zhou C, Blackwell S, Zhang Y, Wang Z, et al. Involvement of budding yeast Rad5 in translesion DNA synthesis through physical interaction with Rev1. Nucleic Acids Res. 2016;44:5231-45 pubmed publisher
    ..This study indicates that Rad5 plays a critical role in pathway choice between TLS and error-free DDT. ..
  9. Fan L, Xiao W. The Pol30-K196 residue plays a critical role in budding yeast DNA postreplication repair through interaction with Rad18. DNA Repair (Amst). 2016;47:42-48 pubmed publisher
    ..Together with the Pol30-Ub fusion data, we believe that we have identified a putative Rad18-binding pocket in Pol30 that is required for PCNA monoubiquitination and PRR. ..

More Information


  1. Wang Q, Zang Y, Zhou X, Xiao W. Characterization of four rice UEV1 genes required for Lys63-linked polyubiquitination and distinct functions. BMC Plant Biol. 2017;17:126 pubmed publisher
    ..We speculate that different OsUev1s play distinct roles by serving as a regulatory subunit of the Ubc13-Uev1 complex to respond to diverse cellular, developmental and environmental signals. ..
  2. Li F, Ball L, Fan L, Hanna M, Xiao W. Sgs1 helicase is required for efficient PCNA monoubiquitination and translesion DNA synthesis in Saccharomyces cerevisiae. Curr Genet. 2018;64:459-468 pubmed publisher
    ..These studies collectively illustrate that Sgs1 participates in both branches of DDT and possibly plays a role in pathway choice. ..
  3. Zhang Y, Li Y, Yang X, Wang J, Wang R, Qian X, et al. Uev1A-Ubc13 catalyzes K63-linked ubiquitination of RHBDF2 to promote TACE maturation. Cell Signal. 2018;42:155-164 pubmed publisher
    ..Furthermore, upon TNF? stimulation, the Uev1A-Ubc13 complex cooperates with CHIP to promote K63-linked ubiquitination of RHBDF2, enhancing its activity toward TACE maturation and subsequently blocking TNF?-induced NF-?B signaling. ..
  4. Qin Z, Jiang W, Wang G, Sun Y, Xiao W. Linear ubiquitin chain induces apoptosis and inhibits tumor growth. Apoptosis. 2018;23:16-26 pubmed publisher