Joanne L Wright

Summary

Affiliation: University of British Columbia
Country: Canada

Publications

  1. ncbi A model of tobacco smoke-induced airflow obstruction in the guinea pig
    Joanne L Wright
    Department of Pathology, University of British Columbia, 2211 Westbrook Mall, Vancouver, BC, V6T 2B5, Canada
    Chest 121:188S-191S. 2002
  2. ncbi Pulmonary hypertension and vascular oxidative damage in cigarette smoke exposed eNOS(-/-) mice and human smokers
    J L Wright
    Department of Pathology, University of British Columbia, Vancouver, B C Canada
    Inhal Toxicol 24:732-40. 2012
  3. ncbi Synthetic serine elastase inhibitor reduces cigarette smoke-induced emphysema in guinea pigs
    Joanne L Wright
    Department of Pathology, University of British Columbia, Vancouver, British Columbia, Canada
    Am J Respir Crit Care Med 166:954-60. 2002
  4. ncbi Current concepts in mechanisms of emphysema
    J L Wright
    Department of Pathology, University of British Columbia, Vancouver, Canada
    Toxicol Pathol 35:111-5. 2007
  5. ncbi Cigarette smoke induces rapid changes in gene expression in pulmonary arteries
    Joanne L Wright
    Department of Pathology, University of British Columbia, Vancouver, British Columbia, Canada
    Lab Invest 82:1391-8. 2002
  6. ncbi Smoking cessation decreases the number of metaplastic secretory cells in the small airways of the Guinea pig
    J L Wright
    Department of Pathology, University of British Columbia, Vancouver, Canada
    Inhal Toxicol 14:1153-9. 2002
  7. ncbi Animal models of cigarette smoke-induced COPD
    Joanne L Wright
    Department of Pathology, University of British Columbia, Vancouver, BC, Canada
    Chest 122:301S-306S. 2002
  8. ncbi Commentary--Pathophysiology of airflow obstruction: could there really be an early test of prognostic significance?
    J L Wright
    Department of Pathology, University of British Columbia, 2211 Wesbrook Mall, Room GF164, VGT 2B5, Vancouver, British Columbia, Canada
    COPD 1:93-5. 2004
  9. ncbi Cigarette smoke upregulates pulmonary vascular matrix metalloproteinases via TNF-alpha signaling
    J L Wright
    Department of Pathology, University of British Columbia, 2211 Wesbrook Mall, Vancouver, BC, Canada V6T 2B5, USA
    Am J Physiol Lung Cell Mol Physiol 292:L125-33. 2007
  10. ncbi Advances in the pathology of COPD
    J L Wright
    Department of Pathology, University of British Columbia, Vancouver, BC, Canada
    Histopathology 49:1-9. 2006

Collaborators

Detail Information

Publications64

  1. ncbi A model of tobacco smoke-induced airflow obstruction in the guinea pig
    Joanne L Wright
    Department of Pathology, University of British Columbia, 2211 Westbrook Mall, Vancouver, BC, V6T 2B5, Canada
    Chest 121:188S-191S. 2002
    ..Other animal models exist, however, and the investigator should select the model that is most suited to the hypothesis to be tested...
  2. ncbi Pulmonary hypertension and vascular oxidative damage in cigarette smoke exposed eNOS(-/-) mice and human smokers
    J L Wright
    Department of Pathology, University of British Columbia, Vancouver, B C Canada
    Inhal Toxicol 24:732-40. 2012
    ..Most likely the source of reactive nitrogen species is the cigarette smoke itself...
  3. ncbi Synthetic serine elastase inhibitor reduces cigarette smoke-induced emphysema in guinea pigs
    Joanne L Wright
    Department of Pathology, University of British Columbia, Vancouver, British Columbia, Canada
    Am J Respir Crit Care Med 166:954-60. 2002
    ..These data demonstrate that a serine elastase inhibitor ameliorates the inflammatory and destructive effects of cigarette smoke, and that these effects are mediated in part by neutrophils and by smoke-driven TNF-alpha production...
  4. ncbi Current concepts in mechanisms of emphysema
    J L Wright
    Department of Pathology, University of British Columbia, Vancouver, Canada
    Toxicol Pathol 35:111-5. 2007
    ..Over the last 10 years, there has been a remarkable degree of progress in our understanding of the pathophysiological mechanisms involved in the genesis of emphysema. This review attempts to summarize these data...
  5. ncbi Cigarette smoke induces rapid changes in gene expression in pulmonary arteries
    Joanne L Wright
    Department of Pathology, University of British Columbia, Vancouver, British Columbia, Canada
    Lab Invest 82:1391-8. 2002
    ..These changes support the idea that pulmonary hypertension in cigarette smokers reflects a direct effect of smoke on the vasculature. The pattern of response in the vessels is distinctly different from that in the airways...
  6. ncbi Smoking cessation decreases the number of metaplastic secretory cells in the small airways of the Guinea pig
    J L Wright
    Department of Pathology, University of British Columbia, Vancouver, Canada
    Inhal Toxicol 14:1153-9. 2002
    ..We conclude that, in a guinea pig model, smoking produces secretory-cell metaplasia in the airways and that smoking cessation allows partial recovery of normal structure...
  7. ncbi Animal models of cigarette smoke-induced COPD
    Joanne L Wright
    Department of Pathology, University of British Columbia, Vancouver, BC, Canada
    Chest 122:301S-306S. 2002
    ..To review the animal models of COPD, and to compare these data to those found in humans...
  8. ncbi Commentary--Pathophysiology of airflow obstruction: could there really be an early test of prognostic significance?
    J L Wright
    Department of Pathology, University of British Columbia, 2211 Wesbrook Mall, Room GF164, VGT 2B5, Vancouver, British Columbia, Canada
    COPD 1:93-5. 2004
    ..Milic-Emili in this issue. The authors discuss the hyphothesis and suggest that a re-examination of longitudinal lung function data could prove or deny his suggestion...
  9. ncbi Cigarette smoke upregulates pulmonary vascular matrix metalloproteinases via TNF-alpha signaling
    J L Wright
    Department of Pathology, University of British Columbia, 2211 Wesbrook Mall, Vancouver, BC, Canada V6T 2B5, USA
    Am J Physiol Lung Cell Mol Physiol 292:L125-33. 2007
    ..MMP production is largely TNF-alpha dependent, further supporting the importance of TNF-alpha in the pathogenesis of cigarette smoke-induced lung disease...
  10. ncbi Advances in the pathology of COPD
    J L Wright
    Department of Pathology, University of British Columbia, Vancouver, BC, Canada
    Histopathology 49:1-9. 2006
    ..This review is designed to help surgical pathologists evaluate the lungs of subjects who have clinical manifestations of airflow obstruction so that appropriate clinical-pathological correlations can be performed...
  11. ncbi A neutrophil elastase inhibitor reduces cigarette smoke-induced remodelling of lung vessels
    J L Wright
    Dept of Pathology, University of British Columbia, Vancouver, Canada
    Eur Respir J 22:77-81. 2003
    ..These data suggest that smoke-induced cell proliferation leads to pulmonary arterial muscularisation. Serine-elastase inhibitors appear to be able to reduce cell proliferation and vascular remodelling...
  12. ncbi Vasoactive mediators and pulmonary hypertension after cigarette smoke exposure in the guinea pig
    Joanne L Wright
    Dept of Pathology, University of British Columbia, 2211 Wesbrook Mall, Vancouver, BC, Canada V6T 2B5
    J Appl Physiol 100:672-8. 2006
    ....
  13. ncbi Cigarette smoke induces persisting increases of vasoactive mediators in pulmonary arteries
    Joanne L Wright
    Department of Pathology, University of British Columbia, Vancouver, British Columbia, Canada
    Am J Respir Cell Mol Biol 31:501-9. 2004
    ..These changes may be important in the development of smoke-induced pulmonary hypertension...
  14. ncbi Airway remodeling in the smoke exposed guinea pig model
    J L Wright
    Department of Pathology, University of British Columbia, Vancouver, British Columbia, Canada
    Inhal Toxicol 19:915-23. 2007
    ..This model should prove useful in further investigations into the mechanisms of airway remodeling...
  15. ncbi Diseases of the small airways
    J L Wright
    Department of Pathology, University of British Columbia, Vancouver, Canada
    Lung 179:375-96. 2001
    ..Although almost all of the processes described herein are associated with activation of cytokines, ecosanoids, or peptide hormones, detailed descriptions of these interactions are beyond the scope of this article...
  16. ncbi Animal models of COPD: Barriers, successes, and challenges
    Joanne L Wright
    Department of Pathology, University of British Columbia
    Pulm Pharmacol Ther 21:696-8. 2008
    ..Animal models have definite utility in the study of chronic obstructive pulmonary disease. However, choice of model must be determined with the full knowledge of their value, or potential limitations...
  17. ncbi Animal models of cigarette smoke-induced chronic obstructive pulmonary disease
    Joanne L Wright
    Department of Pathology, University Hospital, University of British Columbia, 2211 Wesbrook Mall, Vancouver, BC V6T 2B5, Canada
    Expert Rev Respir Med 4:723-34. 2010
    ..The various different anatomic lesions induced by smoke appear to be largely independent effects and may require different therapeutic approaches...
  18. ncbi Fibrosis with emphysema
    Joanne L Wright
    Department of Pathology, University of British Columbia, Vancouver, BC, Canada
    Histopathology 58:517-24. 2011
    ..Care should be taken when describing these lesions in biopsies so as not to give the impression that a diffuse interstitial lung disease is present...
  19. ncbi Pulmonary hypertension in chronic obstructive pulmonary disease: current theories of pathogenesis and their implications for treatment
    J L Wright
    Department of Pathology, University of Columbia, Vancouver, BC, Canada
    Thorax 60:605-9. 2005
    ..These changes are in many ways similar to those seen in other forms of pulmonary hypertension and suggest that the treatments used for primary pulmonary hypertension may be beneficial in patients with COPD...
  20. ncbi Animal models of chronic obstructive pulmonary disease
    Joanne L Wright
    Department of Pathology, University of British Columbia, Vancouver, British Columbia, Canada
    Am J Physiol Lung Cell Mol Physiol 295:L1-15. 2008
    ....
  21. ncbi Short-term exposure to cigarette smoke induces endothelial dysfunction in small intrapulmonary arteries: analysis using guinea pig precision cut lung slices
    J L Wright
    Department of Pathology, University of British Columbia, University Hospital, 2211 Wesbrook Mall, Vancouver, BC, Canada
    J Appl Physiol 104:1462-9. 2008
    ..These changes may be important in the development of pulmonary hypertension...
  22. ncbi Statin reverses smoke-induced pulmonary hypertension and prevents emphysema but not airway remodeling
    Joanne L Wright
    Department of Pathology, University of British Columbia, 2211 Wesbrook Mall, Vancouver, BC, V6T 2B5 Canada
    Am J Respir Crit Care Med 183:50-8. 2011
    ..the potential role of statins in treating chronic obstructive pulmonary disease (COPD) is controversial, and it is unclear what anatomic COPD lesions statins affect...
  23. ncbi Diffuse calcification of the airways
    J Wright
    Department of Pathology, St Paul s Hospital, Vancouver, British Columbia, Canada
    Mod Pathol 14:717-9. 2001
    ..Pathologists should not exclude metastatic calcification when considering the etiology of bronchial calcification...
  24. ncbi The importance of ultramicroscopic emphysema in cigarette smoke-induced lung disease
    J L Wright
    Department of Pathology, University of British Columbia, Vancouver, B C, V6T 2B5, Canada
    Lung 179:71-81. 2001
    ..This is the first study to clearly document an increased number of alveolar pores, with a significant number of either/or large and irregular pores, after chronic smoke exposure, but in the absence of gross emphysema...
  25. ncbi Tumor necrosis factor-alpha is central to acute cigarette smoke-induced inflammation and connective tissue breakdown
    Andrew Churg
    Department of Pathology, University of British Columbia, Vancouver, British Columbia, Canada
    Am J Respir Crit Care Med 166:849-54. 2002
    ..The findings support the idea that TNF-alpha promoter polymorphisms may be of importance in determining who develops smoke-induced chronic obstructive pulmonary disease...
  26. ncbi Tumor necrosis factor-alpha drives 70% of cigarette smoke-induced emphysema in the mouse
    Andrew Churg
    Department of Pathology, University of British Columbia, 2211 Wesbrook Mall, Vancouver, BC, V6T 2B5 Canada
    Am J Respir Crit Care Med 170:492-8. 2004
    ..These findings imply a second TNF-alpha-independent process, possibly related to direct MMP attack on matrix, that produces the remaining 30% of airspace enlargement...
  27. ncbi Expression of profibrotic mediators in small airways versus parenchyma after cigarette smoke exposure
    Andrew Churg
    Department of Pathology, University of British Columbia, 2211 Wesbrook Mall, Vancouver, BC, V6T 2B5 Canada
    Am J Respir Cell Mol Biol 40:268-76. 2009
    ..These observations support the idea that the parenchyma largely fails to repair smoke-induced matrix damage, but this phenomenon is a relatively late event...
  28. ncbi The role of interleukin-1beta in murine cigarette smoke-induced emphysema and small airway remodeling
    Andrew Churg
    Department of Pathology, University of British Columbia, 2211 Wesbrook Mall, Vancouver, BC V6T2B5, Canada
    Am J Respir Cell Mol Biol 40:482-90. 2009
    ....
  29. ncbi Effect of an MMP-9/MMP-12 inhibitor on smoke-induced emphysema and airway remodelling in guinea pigs
    Andrew Churg
    Department of Pathology, University of British Columbia, Vancouver, BC, Canada V6T 2B5
    Thorax 62:706-13. 2007
    ..The role of MMPs in smoke-induced small airway remodelling is unknown...
  30. ncbi Cigarette smoke produces airway wall remodeling in rat tracheal explants
    Rong D Wang
    Department of Pathology, University of British Columbia, 2211 Wesbrook Mall, Vancouver, BC, V6T 2B5 Canada
    Am J Respir Crit Care Med 168:1232-6. 2003
    ..Smoke-evoked inflammatory cells are not required for this process...
  31. ncbi Cigarette smoke drives small airway remodeling by induction of growth factors in the airway wall
    Andrew Churg
    Department of Pathology, University of British Columbia, 2211 Wesbrook Mall, Vancouver, BC, Canada V6T 2B5
    Am J Respir Crit Care Med 174:1327-34. 2006
    ..Small airway remodeling (SAR) is an important cause of airflow obstruction in cigarette smokers with chronic obstructive pulmonary disease, but the pathogenesis of SAR is not understood...
  32. ncbi Alpha1-antitrypsin suppresses TNF-alpha and MMP-12 production by cigarette smoke-stimulated macrophages
    Andrew Churg
    Department of Pathology, University of British Columbia, 2211 Wesbrook Mall, Vancouver, BC, V6T 2B5 Canada
    Am J Respir Cell Mol Biol 37:144-51. 2007
    ....
  33. ncbi Late intervention with a myeloperoxidase inhibitor stops progression of experimental chronic obstructive pulmonary disease
    Andrew Churg
    Department of Pathology and UBC James Hogg Research Centre, Institute for Heart and Lung Health, University of British Columbia, Vancouver, British Columbia, Canada
    Am J Respir Crit Care Med 185:34-43. 2012
    ..Myeloperoxidase (MPO), a neutrophil and macrophage product, is important in bacterial killing, but also drives inflammatory reactions and tissue oxidation...
  34. ncbi Macrophage metalloelastase mediates acute cigarette smoke-induced inflammation via tumor necrosis factor-alpha release
    Andrew Churg
    Department of Pathology, University of British Columbia, Vancouver, Canada
    Am J Respir Crit Care Med 167:1083-9. 2003
    ..TNF-alpha release may be a general mechanism whereby metalloproteases drive cigarette smoke-induced inflammation...
  35. ncbi Acute cigarette smoke-induced connective tissue breakdown requires both neutrophils and macrophage metalloelastase in mice
    Andrew Churg
    Department of Pathology, University of British Columbia, Vancouver, British Columbia, Canada
    Am J Respir Cell Mol Biol 27:368-74. 2002
    ....
  36. ncbi Respiratory bronchiolitis/interstitial lung disease: fibrosis, pulmonary function, and evolving concepts
    Andrew Churg
    Department of Pathology, University of British Columbia, Vancouver, Canada
    Arch Pathol Lab Med 134:27-32. 2010
    ..Over time, the diagnostic criteria for RBILD have become progressively more confused...
  37. ncbi Transforming growth factor-beta1 drives airway remodeling in cigarette smoke-exposed tracheal explants
    Rong D Wang
    Department of Pathology, University of British Columbia, Vancouver, BC, V6T 2B5 Canada
    Am J Respir Cell Mol Biol 33:387-93. 2005
    ....
  38. ncbi Mechanisms of cigarette smoke-induced COPD: insights from animal models
    Andrew Churg
    Department of Pathology, University of British Columbia, Vancouver, British Columbia, Canada
    Am J Physiol Lung Cell Mol Physiol 294:L612-31. 2008
    ..Emphysema, small airway remodeling, pulmonary hypertension, and mucus production appear to be at least partially independent processes that may require different therapeutic approaches...
  39. ncbi Regional heterogeneity in murine lung fibroblasts from normal mice or mice exposed once to cigarette smoke
    Olena Preobrazhenska
    Department of Pathology, University of British Columbia, Vancouver, British Columbia, Canada
    PLoS ONE 7:e39761. 2012
    ..However, PF still retain the ability to repair by producing new matrix after a single in vivo smoke exposure...
  40. ncbi Acute exacerbation (acute lung injury of unknown cause) in UIP and other forms of fibrotic interstitial pneumonias
    Andrew Churg
    Department of Pathology, University of British Columbia, Vancouver, BC, Canada
    Am J Surg Pathol 31:277-84. 2007
    ..Our data also imply that survival (of the acute episode) may be better than the literature suggests...
  41. ncbi Cigarette smoke causes small airway remodeling by direct growth factor induction and release
    Andrew Churg
    Department of Pathology, University of British Columbia, 2211 Wesbrook Mall, Vancouver, BC Canada V6T 2B5
    Proc Am Thorac Soc 3:493. 2006
  42. ncbi alpha-1-Antitrypsin ameliorates cigarette smoke-induced emphysema in the mouse
    Andrew Churg
    Department of Pathology, University of British Columbia, 2211 Wesbrook Mall, Vancouver, BC, Canada V6T 2B5
    Am J Respir Crit Care Med 168:199-207. 2003
    ..We conclude that A1AT therapy ameliorates smoke-induced inflammation and matrix breakdown, possibly via an antiinflammatory mechanism related to tumor necrosis factor-alpha suppression, and provides partial protection against emphysema...
  43. ncbi Chronic exposure to high levels of particulate air pollution and small airway remodeling
    Andrew Churg
    Department of Pathology, University of British Columbia, Vancouver, British Columbia, Canada
    Environ Health Perspect 111:714-8. 2003
    ..This process may produce chronic airflow obstruction...
  44. ncbi Testing drugs in animal models of cigarette smoke-induced chronic obstructive pulmonary disease
    Andrew Churg
    Department of Pathology, University of British Columbia, Vancouver, BC V6T 2B5 Canada
    Proc Am Thorac Soc 6:550-2. 2009
    ....
  45. ncbi Effect of ECE and NEP inhibition on cigarette smoke-induced cell proliferation in the rat lung
    J L Wright
    Department of Pathology, University of British Columbia, 2211 Wesbrook Mall, Vancouver, British Columbia V6T 2B5, Canada
    Inhal Toxicol 13:497-511. 2001
    ..The effectiveness of the more potent inhibitor, CGS 26303, appears to conform to its site of predominant expression...
  46. ncbi Airway wall remodeling induced by occupational mineral dusts and air pollutant particles
    Andrew Churg
    Department of Pathology, University of British Columbia, Vancouver, BC, Canada
    Chest 122:306S-309S. 2002
    ..The studies here investigate the hypothesis that particulates, including air pollution particles, can induce airway wall fibrosis, a process that can lead to COPD...
  47. ncbi Animal models of cigarette smoke-induced chronic obstructive lung disease
    Andrew Churg
    Department of Pathology, University of British Columbia, Vancouver, B C, Canada
    Contrib Microbiol 14:113-25. 2007
    ..There are no models of cigarette smoke-induced chronic bronchitis in animals and there are no models of acute exacerbations of COPD...
  48. ncbi Acute exacerbations of fibrotic interstitial lung disease
    Andrew Churg
    Department of Pathology, University of British Columbia, Vancouver, BC, Canada
    Histopathology 58:525-30. 2011
    ..The aetiology of acute exacerbations is unknown, and the prognosis is poor; however, some patients survive with high-dose steroid therapy...
  49. ncbi Everything prevents emphysema: are animal models of cigarette smoke-induced chronic obstructive pulmonary disease any use?
    Andrew Churg
    Department of Pathology, University of British Columbia, Vancouver, Canada
    Am J Respir Cell Mol Biol 45:1111-5. 2011
    ..This approach, combined with the realization that human COPD probably needs early rather than late treatment, may make development of treatments based on animal models more relevant...
  50. ncbi Proteases and emphysema
    Andrew Churg
    Department of Pathology, University of British Columbia, Vancouver, BC, Canada
    Curr Opin Pulm Med 11:153-9. 2005
    ..The protease-antiprotease theory of emphysema is widely accepted, but exactly which cells/proteases play a role continues to be a controversial subject...
  51. ncbi Chronic hypersensitivity pneumonitis
    Andrew Churg
    Department of Pathology, University of British Columbia, Vancouver, British Columbia, Canada
    Am J Surg Pathol 30:201-8. 2006
    ..Despite the presence of extensive fibrosis, some patients responded to removal from exposure and steroid therapy...
  52. ncbi Alpha-1-antitrypsin and a broad spectrum metalloprotease inhibitor, RS113456, have similar acute anti-inflammatory effects
    A Churg
    Department of Pathology, University of British Columbia, Vancouver, British Columbia, Canada
    Lab Invest 81:1119-31. 2001
    ..The antiproteolytic effects of these agents do not seem to be mediated by protection of endogenous alpha1AT...
  53. ncbi Idiopathic pulmonary fibrosis: spectrum of high-resolution CT findings
    Carolina Althoff Souza
    Department of Radiology, Vancouver General Hospital, University of British Columbia, 899 W. 12th Ave, Vancouver, BC V5Z 1M9, Canada
    AJR Am J Roentgenol 185:1531-9. 2005
    ....
  54. ncbi Effect of long-term cigarette smoke exposure on pulmonary vascular structure and function in the guinea pig
    J L Wright
    Department of Pathology, University of British Columbia, Vancouver, Canada
    Exp Lung Res 17:997-1009. 1991
    ..The etiology of this process may be smoke-induced inflammation with release of vasoactive substances as well as proteolytic enzymes...
  55. ncbi Effects of cigarette smoke exposure on retention of asbestos fibers in various morphologic compartments of the guinea pig lung
    A Churg
    Department of Pathology, University of British Columbia, Vancouver, Canada
    Am J Pathol 129:385-93. 1987
    ....
  56. ncbi Effects of cigarette smoke on the clearance of short asbestos fibres from the lung and a comparison with the clearance of long asbestos fibres
    A Churg
    Department of Pathology, University of British Columbia, Vancouver, Canada
    Int J Exp Pathol 73:287-97. 1992
    ..These observations suggest that short asbestos fibres could play an important role in the pathogenesis of some types of asbestos-related disease in cigarette smokers...
  57. ncbi alpha1-Antitrypsin monotherapy induces immune tolerance during islet allograft transplantation in mice
    Eli C Lewis
    Department of Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Proc Natl Acad Sci U S A 105:16236-41. 2008
    ..Because AAT treatment in humans is safe, its use during human islet transplantation may be considered...
  58. ncbi The complex relationship of serum adiponectin to COPD outcomes COPD and adiponectin
    Ho Il Yoon
    University of British Columbia James Hogg Research Center, Vancouver, BC, Canada
    Chest 142:893-99. 2012
    ..Adiponectin is a hormone that has anti inflammatory, antidiabetic, and anti atherogenic activities. We investigated the relationship of serum adiponectin to health outcomes in COPD...
  59. ncbi Antioxidant gene expression in rat lung after exposure to cigarette smoke
    C B Gilks
    Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, Canada
    Am J Pathol 152:269-78. 1998
    ..MT expression is also transiently increased by smoke whereas GPX expression increases after prolonged (7 to 14 days) exposure to cigarette smoke...
  60. ncbi Hypersensitivity pneumonitis as a cause of airway-centered interstitial fibrosis
    Mark E Fenton
    Division of Respirology, Critical Care and Sleep Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada
    Ann Allergy Asthma Immunol 99:465-6. 2007
    ..Airway-centered interstitial fibrosis (ACIF) has been postulated to be related to environmental exposures...
  61. ncbi Active oxygen species mediate asbestos fiber uptake by tracheal epithelial cells
    J Hobson
    Department of Pathology, University of British Columbia, Vancouver, Canada
    FASEB J 4:3135-9. 1990
    ..We conclude that uptake of amosite asbestos fibers is mediated in part by active oxygen species (most likely OH.), but that other mechanisms of fiber uptake must also exist...
  62. ncbi Effects of cigarette smoke on nitric oxide synthase expression in the rat lung
    J L Wright
    Department of Pathology, University of British Columbia, Vancouver, Canada
    Lab Invest 79:975-83. 1999
    ..These findings indicate that cigarette smoke can directly and rapidly affect NOS expression, and thus potentially affect the function of the pulmonary vasculature...
  63. ncbi Site of methacholine reactivity in the peripheral airways: analysis using lung explants
    J L Wright
    University of British Columbia, Vancouver, Canada
    Am J Physiol 272:L68-72. 1997
    ..They do not, however, completely rule out the possibility of in vivo species-dependent differences in airway-parenchymal interactions...
  64. ncbi Rapid short-term clearance of chrysotile compared with amosite asbestos in the guinea pig
    A Churg
    Department of Pathology, University of British Columbia, Vancouver, Canada
    Am Rev Respir Dis 139:885-90. 1989
    ....