J M Woulfe
Affiliation: University of Ottawa
- Hypothesis: A role for EBV-induced molecular mimicry in Parkinson's diseaseJohn M Woulfe
Centre for Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, Canada Department of Pathology and Laboratory Medicine, University of Ottawa, Ottawa, Canada Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, Canada Electronic address
Parkinsonism Relat Disord 20:685-94. 2014..Further support for an EBV-induced immune pathogenesis for Parkinson's disease could have profound therapeutic implications. ..
- Cathepsin D expression level affects alpha-synuclein processing, aggregation, and toxicity in vivoValerie Cullen
Center for Neurologic Diseases, Department of Neurology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
Mol Brain 2:5. 2009..To date, few enzymes have been examined for their ability to degrade aSyn. Here, we explore the effects of CTSD gene expression, which encodes the lysosomal protease cathepsin D (CathD), on aSyn processing...
- FUS-immunoreactive intranuclear inclusions in neurodegenerative diseaseJohn Woulfe
Cancer Therapeutics Group, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada
Brain Pathol 20:589-97. 2010..NII-bearing cells displayed loss of the normal diffuse nuclear pattern of FUS staining. This suggests that sequestration of nuclear FUS by NIIs may interfere with its normal nuclear localization...
- Nuclear bodies in neurodegenerative diseaseJohn Woulfe
Department of Pathology, The Ottawa Hospital, Civic Campus, 1053 Carling Avenue, Ottawa, Ontario, Canada K1Y 4E9
Biochim Biophys Acta 1783:2195-206. 2008..Although research in this field is in its infancy, identifying alterations in the nucleus in neurodegenerative disease has potentially profound implications for elucidating the pathogenesis of these disorders...
- Promyelocytic leukaemia-immunoreactive neuronal intranuclear rodlets in the human brainJ M Woulfe
Cancer Research Program, The Ottawa Health Research Institute, Ottawa, Ontario, Canada
Neuropathol Appl Neurobiol 33:56-66. 2007..Because both of these structures have been implicated in neurodegenerative disease, PML-INRs may provide a tool with which to study changes in nuclear substructure in disease...
- Abnormalities of the nucleus and nuclear inclusions in neurodegenerative disease: a work in progressJ M Woulfe
Department of Pathology, The Ottawa Hospital, University of Ottawa, and Cancer Research Program, The Ottawa Health Research Institute, Ottawa, Canada
Neuropathol Appl Neurobiol 33:2-42. 2007....
- Class III beta-tubulin immunoreactive intranuclear inclusions in human ependymomas and gangliogliomasJ Woulfe
Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada
Acta Neuropathol 100:427-34. 2000..The functional significance of these inclusions in normal human brain and in cerebral neuroepithelial neoplasms remains to be determined...
- Intranuclear rodlets in the substantia nigra: interactions with marinesco bodies, ubiquitin, and promyelocytic leukemia proteinJohn Woulfe
The Ottawa Hospital, Ottawa, Ontario, Canada
J Neuropathol Exp Neurol 63:1200-7. 2004..These results suggest that structures which subserve the functional compartmentalization of the neuronal nucleus may be relevant to elucidating cellular mechanisms of age-related motor dysfunction...
- Monoclonal antibodies against Epstein-Barr virus cross-react with alpha-synuclein in human brainJ Woulfe
Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Canada
Neurology 55:1398-401. 2000..This example of cross-reactivity between Epstein-Barr virus and alpha-synuclein may bear implications for further elucidating infectious or autoimmune mechanisms in PD...
- Frontotemporal dementia with ubiquitinated cytoplasmic and intranuclear inclusionsJ Woulfe
Department of Pathology, Ottawa Hospital, Ontario, Canada
Acta Neuropathol 102:94-102. 2001..The presence of ubiquitinated intranuclear inclusions along with striatal atrophy in a subset of cases of DMND may signify the existence of a neuropathologically distinct subset of this unique form of FTD...
- Absence of elevated anti-alpha-synuclein and anti-EBV latent membrane protein antibodies in PDJ M Woulfe
Department of Pathology, The University of Ottawa, Hamilton, Ontario, Canada
Neurology 58:1435-6. 2002
- Reduction of neuronal intranuclear rodlets immunoreactive for tubulin and glucocorticoid receptor in Alzheimer's diseaseJohn M Woulfe
Department of Pathology and Laboratory Medicine, The University of Ottawa, The Ottawa Hospital, Ontario, Canada
Brain Pathol 12:300-7. 2002..The marked reduction of these inclusions in Alzheimer's disease may support the concept of a role for stress hormones in Alzheimer's pathogenesis...
- Large French-Canadian family with Lewy body parkinsonism: exclusion of known lociDavid A Grimes
Ottawa Health Research Institute, Ottawa, Canada
Mov Disord 17:1205-12. 2002..This family further demonstrates the known genetic heterogeneity in PD and is large enough that a genome-wide screen has been undertaken in an effort to identify a novel PD gene...
- A family with tau-negative frontotemporal dementia and neuronal intranuclear inclusions linked to chromosome 17Ian R Mackenzie
Department of Pathology, University of British Columbia, Vancouver, Canada
Brain 129:853-67. 2006....
- Hippocampal damage in mouse and human forms of systemic autoimmune diseaseDavid A Ballok
Department of Psychiatry and Behavioral Neurosciences, McMaster University, Hamilton, Ontario, Canada
Hippocampus 14:649-61. 2004..Taken together, these results suggest that systemic autoimmunity induces significant hippocampal damage, which may underlie affective and cognitive deficits in NP-SLE...
- Intranuclear rodlets in human pancreatic islet cellsWendy Prichett
Centre for Cancer Therapeutics, The Ottawa Health Research Institute, Ottawa, Ontario, Canada
Pancreas 35:207-11. 2007..We recently identified these structures in pancreatic islet cells. The objectives of this study are to describe the light microscopic features and cellular pattern of distribution of INRs in human pancreatic islet cells...
- Real-time measurement of free Ca2+ changes in CNS myelin by two-photon microscopyIleana Micu
Division of Neuroscience, Ottawa Health Research Institute, University of Ottawa, Ottawa K1Y 4E9, Canada
Nat Med 13:874-9. 2007..This new technique facilitates detailed studies of living myelin, a vital component of the mammalian CNS...
- Ubiquitin, proteasomes, and the aging brainDouglas A Gray
Ottawa Regional Cancer Centre, Ottawa, Ontario, Canada K1H 1C4
Sci Aging Knowledge Environ 2003:RE6. 2003..These alterations are discussed within the context of prevalent theories of aging...
- Cytoskeletal, synaptic, and nuclear protein changes associated with rat interface organotypic hippocampal slice culture developmentJohn G Mielke
Neurobiology Program, Institute for Biological Sciences, National Research Council of Canada, 1200 Montreal Rd, Building M 54, Ottawa, Ontario, Canada K1A 0R6
Brain Res Dev Brain Res 160:275-86. 2005....
- Lipofuscin and aging: a matter of toxic wasteDouglas A Gray
Ottawa Regional Cancer Centre, Ottawa, Ontario, Canada K1H 1C4
Sci Aging Knowledge Environ 2005:re1. 2005..A damaging feedback loop of lysosomal and proteasomal inhibition may occur as lipofuscin accumulates, leading to what has been appropriately named a "garbage catastrophe." Reversing this catastrophe presents a formidable challenge...
- Role of Cdk5-mediated phosphorylation of Prx2 in MPTP toxicity and Parkinson's diseaseDianbo Qu
Ottawa Health Research Institute, Neuroscience Group, University of Ottawa, Ottawa, K1H 8M5 ON, Canada
Neuron 55:37-52. 2007..Importantly, increased Prx2 phosphorylation also occurs in nigral neurons from postmortem tissue from Parkinson's disease patients when compared to control, suggesting the relevance of this pathway in the human condition...
- MPTP induces intranuclear rodlet formation in midbrain dopaminergic neuronsWiplove Lamba
The University of Ottawa, Ottawa, Ontario, Canada
Brain Res 1066:86-91. 2005..Because tubulin has also been implicated in the pathogenesis of human PD, it is possible that the results of this study will have important implications for this most common neurodegenerative movement disorder...