J M Woulfe

Summary

Affiliation: University of Ottawa
Country: Canada

Publications

  1. ncbi request reprint Hypothesis: A role for EBV-induced molecular mimicry in Parkinson's disease
    John M Woulfe
    Centre for Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, Canada Department of Pathology and Laboratory Medicine, University of Ottawa, Ottawa, Canada Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, Canada Electronic address
    Parkinsonism Relat Disord 20:685-94. 2014
  2. pmc Cathepsin D expression level affects alpha-synuclein processing, aggregation, and toxicity in vivo
    Valerie Cullen
    Center for Neurologic Diseases, Department of Neurology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Mol Brain 2:5. 2009
  3. doi request reprint FUS-immunoreactive intranuclear inclusions in neurodegenerative disease
    John Woulfe
    Cancer Therapeutics Group, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada
    Brain Pathol 20:589-97. 2010
  4. doi request reprint Nuclear bodies in neurodegenerative disease
    John Woulfe
    Department of Pathology, The Ottawa Hospital, Civic Campus, 1053 Carling Avenue, Ottawa, Ontario, Canada K1Y 4E9
    Biochim Biophys Acta 1783:2195-206. 2008
  5. ncbi request reprint Promyelocytic leukaemia-immunoreactive neuronal intranuclear rodlets in the human brain
    J M Woulfe
    Cancer Research Program, The Ottawa Health Research Institute, Ottawa, Ontario, Canada
    Neuropathol Appl Neurobiol 33:56-66. 2007
  6. ncbi request reprint Abnormalities of the nucleus and nuclear inclusions in neurodegenerative disease: a work in progress
    J M Woulfe
    Department of Pathology, The Ottawa Hospital, University of Ottawa, and Cancer Research Program, The Ottawa Health Research Institute, Ottawa, Canada
    Neuropathol Appl Neurobiol 33:2-42. 2007
  7. ncbi request reprint Class III beta-tubulin immunoreactive intranuclear inclusions in human ependymomas and gangliogliomas
    J Woulfe
    Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada
    Acta Neuropathol 100:427-34. 2000
  8. ncbi request reprint Intranuclear rodlets in the substantia nigra: interactions with marinesco bodies, ubiquitin, and promyelocytic leukemia protein
    John Woulfe
    The Ottawa Hospital, Ottawa, Ontario, Canada
    J Neuropathol Exp Neurol 63:1200-7. 2004
  9. ncbi request reprint Monoclonal antibodies against Epstein-Barr virus cross-react with alpha-synuclein in human brain
    J Woulfe
    Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Canada
    Neurology 55:1398-401. 2000
  10. ncbi request reprint Frontotemporal dementia with ubiquitinated cytoplasmic and intranuclear inclusions
    J Woulfe
    Department of Pathology, Ottawa Hospital, Ontario, Canada
    Acta Neuropathol 102:94-102. 2001

Collaborators

Detail Information

Publications22

  1. ncbi request reprint Hypothesis: A role for EBV-induced molecular mimicry in Parkinson's disease
    John M Woulfe
    Centre for Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, Canada Department of Pathology and Laboratory Medicine, University of Ottawa, Ottawa, Canada Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, Canada Electronic address
    Parkinsonism Relat Disord 20:685-94. 2014
    ..Further support for an EBV-induced immune pathogenesis for Parkinson's disease could have profound therapeutic implications. ..
  2. pmc Cathepsin D expression level affects alpha-synuclein processing, aggregation, and toxicity in vivo
    Valerie Cullen
    Center for Neurologic Diseases, Department of Neurology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Mol Brain 2:5. 2009
    ..To date, few enzymes have been examined for their ability to degrade aSyn. Here, we explore the effects of CTSD gene expression, which encodes the lysosomal protease cathepsin D (CathD), on aSyn processing...
  3. doi request reprint FUS-immunoreactive intranuclear inclusions in neurodegenerative disease
    John Woulfe
    Cancer Therapeutics Group, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada
    Brain Pathol 20:589-97. 2010
    ..NII-bearing cells displayed loss of the normal diffuse nuclear pattern of FUS staining. This suggests that sequestration of nuclear FUS by NIIs may interfere with its normal nuclear localization...
  4. doi request reprint Nuclear bodies in neurodegenerative disease
    John Woulfe
    Department of Pathology, The Ottawa Hospital, Civic Campus, 1053 Carling Avenue, Ottawa, Ontario, Canada K1Y 4E9
    Biochim Biophys Acta 1783:2195-206. 2008
    ..Although research in this field is in its infancy, identifying alterations in the nucleus in neurodegenerative disease has potentially profound implications for elucidating the pathogenesis of these disorders...
  5. ncbi request reprint Promyelocytic leukaemia-immunoreactive neuronal intranuclear rodlets in the human brain
    J M Woulfe
    Cancer Research Program, The Ottawa Health Research Institute, Ottawa, Ontario, Canada
    Neuropathol Appl Neurobiol 33:56-66. 2007
    ..Because both of these structures have been implicated in neurodegenerative disease, PML-INRs may provide a tool with which to study changes in nuclear substructure in disease...
  6. ncbi request reprint Abnormalities of the nucleus and nuclear inclusions in neurodegenerative disease: a work in progress
    J M Woulfe
    Department of Pathology, The Ottawa Hospital, University of Ottawa, and Cancer Research Program, The Ottawa Health Research Institute, Ottawa, Canada
    Neuropathol Appl Neurobiol 33:2-42. 2007
    ....
  7. ncbi request reprint Class III beta-tubulin immunoreactive intranuclear inclusions in human ependymomas and gangliogliomas
    J Woulfe
    Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada
    Acta Neuropathol 100:427-34. 2000
    ..The functional significance of these inclusions in normal human brain and in cerebral neuroepithelial neoplasms remains to be determined...
  8. ncbi request reprint Intranuclear rodlets in the substantia nigra: interactions with marinesco bodies, ubiquitin, and promyelocytic leukemia protein
    John Woulfe
    The Ottawa Hospital, Ottawa, Ontario, Canada
    J Neuropathol Exp Neurol 63:1200-7. 2004
    ..These results suggest that structures which subserve the functional compartmentalization of the neuronal nucleus may be relevant to elucidating cellular mechanisms of age-related motor dysfunction...
  9. ncbi request reprint Monoclonal antibodies against Epstein-Barr virus cross-react with alpha-synuclein in human brain
    J Woulfe
    Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Canada
    Neurology 55:1398-401. 2000
    ..This example of cross-reactivity between Epstein-Barr virus and alpha-synuclein may bear implications for further elucidating infectious or autoimmune mechanisms in PD...
  10. ncbi request reprint Frontotemporal dementia with ubiquitinated cytoplasmic and intranuclear inclusions
    J Woulfe
    Department of Pathology, Ottawa Hospital, Ontario, Canada
    Acta Neuropathol 102:94-102. 2001
    ..The presence of ubiquitinated intranuclear inclusions along with striatal atrophy in a subset of cases of DMND may signify the existence of a neuropathologically distinct subset of this unique form of FTD...
  11. ncbi request reprint Absence of elevated anti-alpha-synuclein and anti-EBV latent membrane protein antibodies in PD
    J M Woulfe
    Department of Pathology, The University of Ottawa, Hamilton, Ontario, Canada
    Neurology 58:1435-6. 2002
  12. ncbi request reprint Reduction of neuronal intranuclear rodlets immunoreactive for tubulin and glucocorticoid receptor in Alzheimer's disease
    John M Woulfe
    Department of Pathology and Laboratory Medicine, The University of Ottawa, The Ottawa Hospital, Ontario, Canada
    Brain Pathol 12:300-7. 2002
    ..The marked reduction of these inclusions in Alzheimer's disease may support the concept of a role for stress hormones in Alzheimer's pathogenesis...
  13. ncbi request reprint Large French-Canadian family with Lewy body parkinsonism: exclusion of known loci
    David A Grimes
    Ottawa Health Research Institute, Ottawa, Canada
    Mov Disord 17:1205-12. 2002
    ..This family further demonstrates the known genetic heterogeneity in PD and is large enough that a genome-wide screen has been undertaken in an effort to identify a novel PD gene...
  14. ncbi request reprint A family with tau-negative frontotemporal dementia and neuronal intranuclear inclusions linked to chromosome 17
    Ian R Mackenzie
    Department of Pathology, University of British Columbia, Vancouver, Canada
    Brain 129:853-67. 2006
    ....
  15. pmc Hippocampal damage in mouse and human forms of systemic autoimmune disease
    David A Ballok
    Department of Psychiatry and Behavioral Neurosciences, McMaster University, Hamilton, Ontario, Canada
    Hippocampus 14:649-61. 2004
    ..Taken together, these results suggest that systemic autoimmunity induces significant hippocampal damage, which may underlie affective and cognitive deficits in NP-SLE...
  16. ncbi request reprint Intranuclear rodlets in human pancreatic islet cells
    Wendy Prichett
    Centre for Cancer Therapeutics, The Ottawa Health Research Institute, Ottawa, Ontario, Canada
    Pancreas 35:207-11. 2007
    ..We recently identified these structures in pancreatic islet cells. The objectives of this study are to describe the light microscopic features and cellular pattern of distribution of INRs in human pancreatic islet cells...
  17. ncbi request reprint Real-time measurement of free Ca2+ changes in CNS myelin by two-photon microscopy
    Ileana Micu
    Division of Neuroscience, Ottawa Health Research Institute, University of Ottawa, Ottawa K1Y 4E9, Canada
    Nat Med 13:874-9. 2007
    ..This new technique facilitates detailed studies of living myelin, a vital component of the mammalian CNS...
  18. ncbi request reprint Ubiquitin, proteasomes, and the aging brain
    Douglas A Gray
    Ottawa Regional Cancer Centre, Ottawa, Ontario, Canada K1H 1C4
    Sci Aging Knowledge Environ 2003:RE6. 2003
    ..These alterations are discussed within the context of prevalent theories of aging...
  19. ncbi request reprint Cytoskeletal, synaptic, and nuclear protein changes associated with rat interface organotypic hippocampal slice culture development
    John G Mielke
    Neurobiology Program, Institute for Biological Sciences, National Research Council of Canada, 1200 Montreal Rd, Building M 54, Ottawa, Ontario, Canada K1A 0R6
    Brain Res Dev Brain Res 160:275-86. 2005
    ....
  20. ncbi request reprint Lipofuscin and aging: a matter of toxic waste
    Douglas A Gray
    Ottawa Regional Cancer Centre, Ottawa, Ontario, Canada K1H 1C4
    Sci Aging Knowledge Environ 2005:re1. 2005
    ..A damaging feedback loop of lysosomal and proteasomal inhibition may occur as lipofuscin accumulates, leading to what has been appropriately named a "garbage catastrophe." Reversing this catastrophe presents a formidable challenge...
  21. ncbi request reprint Role of Cdk5-mediated phosphorylation of Prx2 in MPTP toxicity and Parkinson's disease
    Dianbo Qu
    Ottawa Health Research Institute, Neuroscience Group, University of Ottawa, Ottawa, K1H 8M5 ON, Canada
    Neuron 55:37-52. 2007
    ..Importantly, increased Prx2 phosphorylation also occurs in nigral neurons from postmortem tissue from Parkinson's disease patients when compared to control, suggesting the relevance of this pathway in the human condition...
  22. ncbi request reprint MPTP induces intranuclear rodlet formation in midbrain dopaminergic neurons
    Wiplove Lamba
    The University of Ottawa, Ottawa, Ontario, Canada
    Brain Res 1066:86-91. 2005
    ..Because tubulin has also been implicated in the pathogenesis of human PD, it is possible that the results of this study will have important implications for this most common neurodegenerative movement disorder...