Research Topics
| Jim WoodgettSummaryAffiliation: University of Toronto Country: Canada Publications
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Detail Information
Publications
Phosphoinositide-dependent phosphorylation of PDK1 regulates nuclear translocationMichael P Scheid
University Health Network, Princess Margaret Hospital, Toronto, Ontario, Canada
Mol Cell Biol 25:2347-63. 2005..Thus, mitogen-stimulated phosphorylation of PDK1 provides a means for directed PDK1 subcellular trafficking, with potential implications for PDK1 signaling...
Recent advances in the protein kinase B signaling pathwayJames R Woodgett
Ontario Cancer Institute Princess Margaret Hospital, 610 University Avenue, Toronto, Ontario M5G 2 M9, Canada
Curr Opin Cell Biol 17:150-7. 2005....- GSK3: an in-Toll-erant protein kinase?James R Woodgett
Nat Immunol 6:751-2. 2005 - Tissue-specific role of glycogen synthase kinase 3beta in glucose homeostasis and insulin actionSatish Patel
Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
Mol Cell Biol 28:6314-28. 2008..These data indicate that there are not only distinct roles for GSK-3alpha and GSK-3beta within the adult but also tissue-specific phenotypes associated with each of these isoforms... - Differential gene expression profile reveals deregulation of pregnancy specific beta1 glycoprotein 9 early during colorectal carcinogenesisSima Salahshor
Department of Medical Biophysics, Ontario Cancer Institute, 610 University Ave, Toronto, Ontario, M5G 2M9, Canada
BMC Cancer 5:66. 2005.... - What is the "gold" standard to indicate a gene inclusively ie including regulatory, promoter or other elements at both ends of the transcribable DNA segment?Jim Woodgett
IUBMB Life 55:285-6. 2003 - Open heart surgery of PI-3 kinase signalingJames R Woodgett
Division of Experimental Therapeutics, Ontario Cancer Institute, 610 University Avenue, Toronto, Ontario M5G 2M9 Canada
Cell Cycle 1:404-5. 2002 - Unravelling the activation mechanisms of protein kinase B/AktMichael P Scheid
Ontario Cancer Institute, 610 University Avenue, Toronto, ON, Canada M5G 2M9
FEBS Lett 546:108-12. 2003..Recent work has better characterized the mechanism of PKB activation, including upstream regulators and secondary binding partners. This minireview refreshes some old concepts with new twists and highlights current outstanding questions... - Systematic discovery of in vivo phosphorylation networksRune Linding
Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Canada
Cell 129:1415-26. 2007..Applying this approach to DNA damage signaling, we show that 53BP1 and Rad50 are phosphorylated by CDK1 and ATM, respectively. We describe a scalable strategy to evaluate predictions, which suggests that BCLAF1 is a GSK-3 substrate... - CD28-dependent activation of protein kinase B/Akt blocks Fas-mediated apoptosis by preventing death-inducing signaling complex assemblyRussell G Jones
Department of Medical Biophysics, Ontario Cancer Institute, University of Toronto, Canada
J Exp Med 196:335-48. 2002..These findings provide a novel link between CD28 and an important apoptosis pathway in vivo, and demonstrate that PI3K/PKB signaling prevents apoptosis by inhibiting DISC assembly... - Multiple phosphoinositide 3-kinase-dependent steps in activation of protein kinase BMichael P Scheid
Department of Experimental Therapeutics, University Health Network Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada
Mol Cell Biol 22:6247-60. 2002.... - Differential gene expression profiling of short and long term denervated muscleJane Batt
Clinical Sciences Division, Department of Medicine, University of Toronto, Toronto, Ontario, Canada
FASEB J 20:115-7. 2006..Understanding of the timing and type of pathological processes that are triggered by denervation may allow the design of interventions that delay or protect muscle from loss of nerve function... - Functional distinctions of protein kinase B/Akt isoforms defined by their influence on cell migrationVuk Stambolic
Ontario Cancer Institute, University Health Network, 610 University Avenue, Toronto, Ontario M5G 2M9, Canada
Trends Cell Biol 16:461-6. 2006..A thorough insight into the isoform-specific roles of PKB/Akt proteins is essential for a full understanding of the complex biological outcomes elicited by PI 3-kinase and PKB/Akt signaling... - Kinase-dead PKB gene therapy combined with hyperthermia for human breast cancerNancy Ma
Division of Experimental Therapeutics, Ontario Cancer Institute, University Health Network, Toronto, Ontario, Canada
Cancer Gene Ther 11:52-60. 2004.... - GSK-3: tricks of the trade for a multi-tasking kinaseBradley W Doble
Ontario Cancer Institute, 610 University Avenue, Toronto, Ontario M5G 2M9, Canada
J Cell Sci 116:1175-86. 2003..Although they are just starting to be characterized in cell culture experiments, these new inhibitors hold promise as therapeutic agents... - Role of the Phox homology domain and phosphorylation in activation of serum and glucocorticoid-regulated kinase-3Maude Tessier
Samuel Lunenfeld Research Institute and Department of Medical Biophysics, University of Toronto, Toronto, Ontario M5G 1X5, Canada
J Biol Chem 281:23978-89. 2006.... - Glycogen synthase kinase 3alpha-specific regulation of murine hepatic glycogen metabolismKatrina MacAulay
Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada
Cell Metab 6:329-37. 2007..We conclude that GSK-3 isoforms exhibit tissue-specific physiological functions and that GSK-3alpha KO mice are insulin sensitive, reinforcing the potential of GSK-3 as a therapeutic target for type II diabetes... - Chronic activation of protein kinase Bbeta/Akt2 leads to multinucleation and cell fusion in human epithelial kidney cells: events associated with tumorigenesisJing Jin
Department of Medical Biophysics and Ontario Cancer Institute, 610 University Avenue, Toronto, Ontario, Canada M5G 2M9
Oncogene 24:5459-70. 2005..These findings suggest that chronic activation of PKBbeta may contribute to genetic instability and autophagy, properties commonly found in tumor cells... - Role of glycogen synthase kinase-3 in cancer: regulation by Wnts and other signaling pathwaysArmen S Manoukian
Division of Experimental Therapeutics, Ontario Cancer Institute Toronto, Canada
Adv Cancer Res 84:203-29. 2002..This review covers recent advances in understanding the physiological roles of this enzyme, particularly in the context of cancer... - Glycogen synthase kinase-3 and cancer: good cop, bad cop?Satish Patel
Samuel Lunenfeld Research Institute, Toronto, ON, Canada
Cancer Cell 14:351-3. 2008..Now, Wang et al. have found the reverse in certain leukemias, possibly paving the way for small-molecule GSK-3 inhibitors as selective anticancer agents... - Serum and glucocorticoid-regulated protein kinases: variations on a themeMaude Tessier
Department of Medical Biophysics, Samuel Lunenfeld Research Institute, University of Toronto, 600 University Avenue, Toronto, Ontario M5G 1X5, Canada
J Cell Biochem 98:1391-407. 2006..Here, we summarize knowledge of the three SGK isoforms and compare and contrast them to PKB with respect to their possible importance in cellular regulation and potential as therapeutic targets... - CD4+ and CD8+ T cell survival is regulated differentially by protein kinase Ctheta, c-Rel, and protein kinase BSamuel D Saibil
Department of Medical Biophysics, University of Toronto, 610 University Avenue, Toronto, Ontario, Canada
J Immunol 178:2932-9. 2007..The survival of CD4+ and CD8+ T cells deficient in either PKCtheta or c-Rel, however, was promoted by the addition of IL-2. Collectively, these data demonstrate that CD4+ and CD8+ T cell survival signals are differentially programmed... - Functional redundancy of GSK-3alpha and GSK-3beta in Wnt/beta-catenin signaling shown by using an allelic series of embryonic stem cell linesBradley W Doble
Samuel Lunenfeld Research Institute, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada
Dev Cell 12:957-71. 2007..The rheostatic regulation of GSK-3 highlights the importance of considering the contributions of both homologs when studying GSK-3 functions in mammalian systems... 
Role of phosphoinositide 3-kinase {alpha}, protein kinase C, and L-type Ca2+ channels in mediating the complex actions of angiotensin II on mouse cardiac contractilityWenbin Liang
Room 68, Fitzgerald Building, 150 College Street, Toronto, Ontario, Canada
Hypertension 56:422-9. 2010..Our results establish that Ang II has complex temporal effects on contractility and L-type Ca(2+) channels in normal mouse myocardium, with the negative inotropic effects requiring PI3Kalpha and PKC activities...- Frequent accumulation of nuclear E-cadherin and alterations in the Wnt signaling pathway in esophageal squamous cell carcinomasSima Salahshor
Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, ON, Canada
Mod Pathol 21:271-81. 2008.... - A molecular compendium of genes expressed in multiple myelomaJaime O Claudio
Division of Experimental Therapeutics, Toronto General Research Institute, University Health Network, 610 University Avenue, Toronto, Ontario, M5G 2M9 Canada
Blood 100:2175-86. 2002..GenBank Accession numbers include BF169967-BF176369, BF185966-BF185969, and BF177280-BF177455... - DREAM is a critical transcriptional repressor for pain modulationHai Ying M Cheng
Amgen Institute, 620 University Avenue, Toronto, Ontario M5G 2C1, Canada
Cell 108:31-43. 2002..Thus, DREAM appears to be a critical transcriptional repressor in pain processing... - Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organizationJing Jin
Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, Ontario M5G 1X5, Canada
Curr Biol 14:1436-50. 2004..This notion has been validated by the broad inhibition of 14-3-3 phosphorylation-dependent binding in vivo and by the specific analysis of AKAP-Lbc, a RhoGEF that is controlled by its interaction with 14-3-3... - Glycogen synthase kinase-3--an overview of an over-achieving protein kinaseLisa Kockeritz
Ontario Cancer Institute, 610 University Avenue, Toronto, Ontario M5G 2M9, Canada
Curr Drug Targets 7:1377-88. 2006..In this introductory chapter we provide a primer on the modes of GSK-3 regulation and a description of the various signaling pathways and cellular processes in which GSK-3 is an active participant... - Targeting glycogen synthase kinase-3 (GSK-3) in the treatment of Type 2 diabetesKatrina MacAulay
Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada
Expert Opin Ther Targets 12:1265-74. 2008..The enzyme is also a focal point for diverse signaling pathways that act to suppress its activity... - Role of glycogen synthase kinase-3 in cell fate and epithelial-mesenchymal transitionsBradley W Doble
Samuel Lunenfeld Research Institute, Toronto, Ont, Canada
Cells Tissues Organs 185:73-84. 2007..This review focuses on the emerging role of GSK-3 as a modulator of cell fate and EMT in the contexts of development, in vitro cell culture and cancer... - Convergence of multiple signaling cascades at glycogen synthase kinase 3: Edg receptor-mediated phosphorylation and inactivation by lysophosphatidic acid through a protein kinase C-dependent intracellular pathwayXianjun Fang
Department of Molecular Therapeutics, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
Mol Cell Biol 22:2099-110. 2002..LPA and potentially other natural ligands primarily utilize a PKC-dependent pathway to modulate GSK-3... - Negative regulation of phosphatidylinositol 3-kinase and Akt signalling pathway by PKCHui C Wen
Department of Pharmacology, College of Medicine, National Taiwan University, Taipei, Taiwan
Cell Signal 15:37-45. 2003..We conclude that phosphatidylinositol 3-kinase/Akt signalling pathway is regulated by PKC in a negative manner... - Negative regulation of mixed lineage kinase 3 by protein kinase B/AKT leads to cell survivalManoj K Barthwal
Division of Molecular Cardiology, Cardiovascular Research Institute, The Texas A and M University System Health Science Center, College of Medicine, Temple 76504, USA
J Biol Chem 278:3897-902. 2003..Thus, these data provide the first direct link between MLK3-mediated cell death and its regulation by a cell survival signaling protein, AKT1... - Phosphorylation of GSK-3beta by cGMP-dependent protein kinase II promotes hypertrophic differentiation of murine chondrocytesYosuke Kawasaki
Sensory and Motor System Medicine, Faculty of Medicine, University of Tokyo, Tokyo, Japan
J Clin Invest 118:2506-15. 2008..These data indicate that hypertrophic differentiation of growth plate chondrocytes during skeletal growth is promoted by phosphorylation and inactivation of GSK-3beta by cGKII... - Glycogen synthase kinase-3beta induces neuronal cell death via direct phosphorylation of mixed lineage kinase 3Rajakishore Mishra
Department of Internal Medicine, Cardiovascular and Cancer Research Institute, The Texas A and M University System HSC, College of Medicine, Texas 76504, USA
J Biol Chem 282:30393-405. 2007..Inhibition of GSK-3 is thus a potential therapeutic strategy for neurodegenerative diseases caused by trophic factor deprivation... - Lithium antagonizes dopamine-dependent behaviors mediated by an AKT/glycogen synthase kinase 3 signaling cascadeJean-Martin Beaulieu
Howard Hughes Medical Institute, Department of Cell Biology and Center for Models of Human Disease, Institute of Genome Sciences and Policy, Duke University Medical Center, Durham, NC 27710, USA
Proc Natl Acad Sci U S A 101:5099-104. 2004.... - Glycogen synthase kinase-3beta haploinsufficiency mimics the behavioral and molecular effects of lithiumW Timothy O'Brien
Division of Hematology Oncology, Department of Medicine, and Howard Hughes Medical Institute, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6148, USA
J Neurosci 24:6791-8. 2004..These observations support a central role for GSK-3beta in mediating behavioral responses to lithium... - Essential roles for GSK-3s and GSK-3-primed substrates in neurotrophin-induced and hippocampal axon growthWoo Yang Kim
UNC Neuroscience Center, University of North Carolina, Chapel Hill, North Carolina 27599, USA
Neuron 52:981-96. 2006..Our results suggest that GSK-3 is a downstream convergent point for many axon growth regulatory pathways and that differential regulation of primed versus all GSK-3 substrates is associated with a specific morphological outcome... - Modulating autoimmunity: pick your PI3 kinasePamela S Ohashi
Nat Med 11:924-5. 2005 - IFN-gamma suppresses IL-10 production and synergizes with TLR2 by regulating GSK3 and CREB/AP-1 proteinsXiaoyu Hu
Arthritis and Tissue Degeneration Program, Hospital for Special Surgery, Weill Graduate School of Medical Sciences of Cornell University, New York, New York 10021, USA
Immunity 24:563-74. 2006..GSK3 and CREB/AP-1 are key players in integrating IFN-gamma and TLR2 responses in innate immunity and inflammation... - Glycogen synthase kinase 3beta is a negative regulator of growth factor-induced activation of the c-Jun N-terminal kinaseShuying Liu
Department of Molecular Therapeutics, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
J Biol Chem 279:51075-81. 2004..These results reveal a novel role for GSK-3beta in signal transduction and cellular responses to growth factors... - GSK-3beta in mouse fibroblasts controls wound healing and fibrosis through an endothelin-1-dependent mechanismMohit Kapoor
Division of Oral Biology and Department of Physiology and Pharmacology, University of Western Ontario, London, Ontario, Canada
J Clin Invest 118:3279-90. 2008..These results suggest that targeting the GSK-3beta pathway or ET-1 may be of benefit in controlling tissue repair and fibrogenic responses in vivo... - The active form of glycogen synthase kinase-3beta is associated with granulovacuolar degeneration in neurons in Alzheimer's diseaseKarelle Leroy
Laboratory of Histology, Neuroanatomy and Neuropathology, , School of Medicine, 808 Route de Lennik, Bldg C-10, 1070 Brussels, Belgium
Acta Neuropathol (Berl) 103:91-9. 2002.... - Homozygous deletion of glycogen synthase kinase 3beta bypasses senescence allowing Ras transformation of primary murine fibroblastsShuying Liu
Department of Systems Biology, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
Proc Natl Acad Sci U S A 105:5248-53. 2008..Thus Ras(V12) and the lack of GSK3beta act in concert to activate the beta-catenin pathway, which may underlie the bypass of senescence and tumorigenic transformation by Ras... - Genetic deficiency of glycogen synthase kinase-3beta corrects diabetes in mouse models of insulin resistanceKatsuya Tanabe
Division of Endocrinology, Metabolism, and Lipid Research, Washington University School of Medicine, St Louis, Missouri, United States of America
PLoS Biol 6:e37. 2008..These results thus form the rationale for developing agents to inhibit this enzyme in obese insulin-resistant individuals to preserve beta-cells and prevent diabetes onset... - JNK1 activity lowers the cellular production of H2O2 and modulates the growth arrest response to scavenging of H2O2 by catalaseThomas J Preston
Hamilton Regional Cancer Centre, Hamilton, Ontario, Canada
Exp Cell Res 285:146-58. 2003..Stable amplification of the JNK1 pathway leads to cellular adaptation to its signal, resulting in a diminished reliance upon H(2)O(2) for efficient growth... - CpG Island microarray probe sequences derived from a physical library are representative of CpG Islands annotated on the human genomeLawrence E Heisler
Department of Laboratory Medicine and Pathobiology, Program in Proteomics and Bioinformatics, University of Toronto Toronto, ON M5S 1A8, Canada
Nucleic Acids Res 33:2952-61. 2005..A browsable database is available on-line to facilitate exploration of the CGIs in this library and their association with annotated genes or promoter elements... - NF-kappaB couples protein kinase B/Akt signaling to distinct survival pathways and the regulation of lymphocyte homeostasis in vivoRussell G Jones
Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada
J Immunol 175:3790-9. 2005..Using gene-deficient and transgenic mouse models, we establish that NF-kappaB1, and not c-Rel, is the critical signaling molecule downstream of the PI3K-PTEN-PKB signaling axis that regulates lymphocyte homeostasis... - Glycogen synthase kinase-3beta heterozygote knockout mice as a model of findings in postmortem schizophrenia brain or as a model of behaviors mimicking lithium action: negative resultsYuly Bersudsky
Stanley Research Center, Faculty of Health Sciences, Ben Gurion University of the Negev, Israel
Behav Pharmacol 19:217-24. 2008....