J R Woodgett

Summary

Affiliation: University of Toronto
Country: Canada

Publications

  1. ncbi request reprint Judging a protein by more than its name: GSK-3
    J R Woodgett
    Ontario Cancer Institute within the Princess Margaret Hospital, 610 University Avenue, Toronto, Ontario, M5G 2M9 Canada
    Sci STKE 2001:re12. 2001
  2. ncbi request reprint PKB/AKT: functional insights from genetic models
    M P Scheid
    Ontario Cancer Institute, 610 University Avenue, Toronto, Ontario, Canada M5G 2M9
    Nat Rev Mol Cell Biol 2:760-8. 2001
  3. ncbi request reprint Expression of active protein kinase B in T cells perturbs both T and B cell homeostasis and promotes inflammation
    M J Parsons
    Department of Medical Biophysics, Ontario Cancer Institute, University of Toronto, Toronto, Ontario, Canada
    J Immunol 167:42-8. 2001
  4. ncbi request reprint Glycogen synthase kinase-3 in insulin and Wnt signalling: a double-edged sword?
    S Patel
    Ontario Cancer Institute, 610 University Avenue, Toronto, Ontario M5G 2M9, Canada
    Biochem Soc Trans 32:803-8. 2004
  5. ncbi request reprint Physiological roles of glycogen synthase kinase-3: potential as a therapeutic target for diabetes and other disorders
    J R Woodgett
    Ontario Cancer Institute, 610 University Avenue, Toronto, Ontario M5G 2M9, Canada
    Curr Drug Targets Immune Endocr Metabol Disord 3:281-90. 2003
  6. ncbi request reprint Glycogen synthase kinase-3: properties, functions, and regulation
    A Ali
    Division of Experimental Therapeutics, Ontario Cancer Institute, 610 University Avenue, Toronto, Ontario, Canada M5G 2M9
    Chem Rev 101:2527-40. 2001
  7. pmc The links between axin and carcinogenesis
    S Salahshor
    Ontario Cancer Institute, Division of Experimental Therapeutics, Toronto, Ontario, Canada, M5G 2M9
    J Clin Pathol 58:225-36. 2005
  8. ncbi request reprint Regulation of Drosophila tracheal system development by protein kinase B
    J Jin
    Division of Cellular and Molecular Biology, Ontario Cancer Institute, University Health Network, Princess Margaret Hospital, Toronto, Ontario, M5G 2M9, Canada
    Dev Cell 1:817-27. 2001
  9. ncbi request reprint Modulation of cellular apoptotic potential: contributions to oncogenesis
    V Stambolic
    Amgen Institute, 620 University Avenue, Toronto, Ontario, Canada
    Oncogene 18:6094-103. 1999
  10. ncbi request reprint The conserved PI3'K/PTEN/Akt signaling pathway regulates both cell size and survival in Drosophila
    S E Scanga
    Department of Medical Biophysics, Division of Cell and Molecular Biology, Ontario Cancer Institute, University Health Network, Princess Margaret Hospital, University of Toronto, 610 University Avenue, Toronto, Ontario, Canada, M5G 2M9
    Oncogene 19:3971-7. 2000

Collaborators

  • A Ali
  • S Patel
  • Sima Salahshor
  • D J Andrew
  • T W Mak
  • V Stambolic
  • A S Manoukian
  • L Ruel
  • H Nishina
  • M J Parsons
  • J Jin
  • J Diao
  • M P Scheid
  • R C Binari
  • S E Scanga
  • K P Hoeflich
  • P S Ohashi
  • B Odermatt
  • L A Tibbles
  • A Bernstein
  • J M Penninger
  • K D Fischer
  • A Shahinian
  • G Natoli
  • F Kiefer
  • A A Khine
  • E Hsu
  • J Penninger
  • M S Tsao
  • D D Isaac
  • N Anthopoulos
  • C D Richardson
  • F Sarangi
  • C Iorio
  • R G Jones
  • B Wetsch
  • D Bouchard
  • B Calvieri
  • B Snow
  • M Peters
  • Z Yao
  • W C Yeh
  • I Kozieradzki
  • D J Templeton
  • A Ianni
  • A Costanzo
  • C Balsano
  • H Takimoto
  • M Levrero
  • R Hakem
  • L Radvanyi
  • A Wakeham
  • M Bachmann
  • A J Oliveira-dos-Santos
  • E A Rubie
  • N Lassam
  • B W Zanke
  • N N Iscove
  • M Anafi
  • T Pawson
  • A Janssen

Detail Information

Publications17

  1. ncbi request reprint Judging a protein by more than its name: GSK-3
    J R Woodgett
    Ontario Cancer Institute within the Princess Margaret Hospital, 610 University Avenue, Toronto, Ontario, M5G 2M9 Canada
    Sci STKE 2001:re12. 2001
    ....
  2. ncbi request reprint PKB/AKT: functional insights from genetic models
    M P Scheid
    Ontario Cancer Institute, 610 University Avenue, Toronto, Ontario, Canada M5G 2M9
    Nat Rev Mol Cell Biol 2:760-8. 2001
    ....
  3. ncbi request reprint Expression of active protein kinase B in T cells perturbs both T and B cell homeostasis and promotes inflammation
    M J Parsons
    Department of Medical Biophysics, Ontario Cancer Institute, University of Toronto, Toronto, Ontario, Canada
    J Immunol 167:42-8. 2001
    ..Therefore, T cell expression of active protein kinase B can alter T cell homeostasis, indirectly influence B cell homeostasis, and promote inflammation in vivo...
  4. ncbi request reprint Glycogen synthase kinase-3 in insulin and Wnt signalling: a double-edged sword?
    S Patel
    Ontario Cancer Institute, 610 University Avenue, Toronto, Ontario M5G 2M9, Canada
    Biochem Soc Trans 32:803-8. 2004
    ....
  5. ncbi request reprint Physiological roles of glycogen synthase kinase-3: potential as a therapeutic target for diabetes and other disorders
    J R Woodgett
    Ontario Cancer Institute, 610 University Avenue, Toronto, Ontario M5G 2M9, Canada
    Curr Drug Targets Immune Endocr Metabol Disord 3:281-90. 2003
    ..This review summarizes current knowledge of GSK-3 with respect to its known functions, together with an assessment of its real-life potential as a drug target for chronic conditions such as type 2 diabetes...
  6. ncbi request reprint Glycogen synthase kinase-3: properties, functions, and regulation
    A Ali
    Division of Experimental Therapeutics, Ontario Cancer Institute, 610 University Avenue, Toronto, Ontario, Canada M5G 2M9
    Chem Rev 101:2527-40. 2001
  7. pmc The links between axin and carcinogenesis
    S Salahshor
    Ontario Cancer Institute, Division of Experimental Therapeutics, Toronto, Ontario, Canada, M5G 2M9
    J Clin Pathol 58:225-36. 2005
    ..Recent biochemical studies of axins indicate that these molecules are the primary limiting components of this pathway. This review explores the intriguing connections between defects in axin function and human diseases...
  8. ncbi request reprint Regulation of Drosophila tracheal system development by protein kinase B
    J Jin
    Division of Cellular and Molecular Biology, Ontario Cancer Institute, University Health Network, Princess Margaret Hospital, Toronto, Ontario, M5G 2M9, Canada
    Dev Cell 1:817-27. 2001
    ..Using a combination of biochemical and transgenic approaches, we show that direct phosphorylation of Trh by PKB at serine 665 is essential for nuclear localization and functional activation of this regulator of branching morphogenesis...
  9. ncbi request reprint Modulation of cellular apoptotic potential: contributions to oncogenesis
    V Stambolic
    Amgen Institute, 620 University Avenue, Toronto, Ontario, Canada
    Oncogene 18:6094-103. 1999
    ..This review focuses on the regulation and mechanisms by which PKB activation protects cells and the oncologic consequences of dysregulation of the pathway...
  10. ncbi request reprint The conserved PI3'K/PTEN/Akt signaling pathway regulates both cell size and survival in Drosophila
    S E Scanga
    Department of Medical Biophysics, Division of Cell and Molecular Biology, Ontario Cancer Institute, University Health Network, Princess Margaret Hospital, University of Toronto, 610 University Avenue, Toronto, Ontario, Canada, M5G 2M9
    Oncogene 19:3971-7. 2000
    ..This study therefore establishes the evolutionary conservation of this signaling pathway in Drosophila. Oncogene (2000) 19, 3971 - 3977...
  11. ncbi request reprint Mediation of TNF receptor-associated factor effector functions by apoptosis signal-regulating kinase-1 (ASK1)
    K P Hoeflich
    Department of Medical Biophysics, Ontario Cancer Institute, 610 University Avenue, Toronto, Ontario M5G 2M9, Canada
    Oncogene 18:5814-20. 1999
    ..Hence, ASK1 is a common mediator of TRAF-regulated SAPK and apoptosis signaling, and the TRAF2 - ASK1 connection completes the signaling cascade from TNF to SAPK/JNK activation...
  12. ncbi request reprint X protein of hepatitis B virus inhibits Fas-mediated apoptosis and is associated with up-regulation of the SAPK/JNK pathway
    J Diao
    Department of Medical Biophysics, University of Toronto, Toronto, Ontario M5G 2M9, Canada
    J Biol Chem 276:8328-40. 2001
    ..Finally, mutational analysis of HBx demonstrated that a potential binding region for 14-3-3 proteins was essential for induction of SAPK/JNK activity and protection from Fas-mediated apoptosis...
  13. ncbi request reprint Regulation of the protein kinase activity of Shaggy(Zeste-white3) by components of the wingless pathway in Drosophila cells and embryos
    L Ruel
    Division of Experimental Therapeutics, Ontario Cancer Institute, and the Department of Medical Biophysics, University of Toronto, Toronto, Ontario M5G 2M9, Canada
    J Biol Chem 274:21790-6. 1999
    ..Together, these results provide direct biochemical evidence in support of the genetic model of Wg signaling and provide a model for dissecting the molecular interactions between the signaling proteins...
  14. pmc Impaired CD28-mediated interleukin 2 production and proliferation in stress kinase SAPK/ERK1 kinase (SEK1)/mitogen-activated protein kinase kinase 4 (MKK4)-deficient T lymphocytes
    H Nishina
    Amgen Institute and Ontario Cancer Institute, Department of Medical Biophysics and Immunology, University of Toronto, M5G 2C1 Toronto, Ontario, Canada
    J Exp Med 186:941-53. 1997
    ..Our data provide the first genetic evidence that SEK1 is an important effector molecule that relays CD28 signaling to IL-2 production and T cell proliferation...
  15. pmc HPK1, a hematopoietic protein kinase activating the SAPK/JNK pathway
    F Kiefer
    Department of Medical Biophysics, University of Toronto, Ontario, Canada
    EMBO J 15:7013-25. 1996
    ..HPK1 therefore provides an example of a cell type-specific input into the SAPK/JNK pathway. The developmental specificity of its expression suggests a potential role in hematopoietic lineage decisions and growth regulation...
  16. ncbi request reprint Stress-signalling kinase Sek1 protects thymocytes from apoptosis mediated by CD95 and CD3
    H Nishina
    The Amgen Institute, Ontario Cancer Institute, Toronto, Canada
    Nature 385:350-3. 1997
    ..These data indicate that SEK1 mediates survival signals in T-cell development...
  17. ncbi request reprint Activation of SAPK/JNK by TNF receptor 1 through a noncytotoxic TRAF2-dependent pathway
    G Natoli
    Fondazione Andrea Cesalpino and Istituto di I Clinica Medica, Policlinico Umberto I, Viale del Policlinico 155, 00161 Rome, Italy
    Science 275:200-3. 1997
    ..Therefore, SAPK activation occurs through a pathway that is not required for TNF-R1-induced apoptosis...