Research Topics
| F WongSummaryAffiliation: University of Toronto Country: Canada Publications
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Detail Information
Publications
Quality of life in refractory ascites: transjugular intrahepatic portal-systemic shunting versus medical therapyMical S Campbell
Division of Gastroenterology, University of Pennsylvania Health Services, Philadelphia, PA 19104, USA
Hepatology 42:635-40. 2005..Competing effects of hepatic encephalopathy, requirement for repeated LVP, and need for hospitalizations explain similar changes in quality of life between the two groups...- Volume expanders for spontaneous bacterial peritonitis: Are we comparing oranges with oranges?Florence Wong
Hepatology 42:533-5. 2005 - The use of TIPS in chronic liver diseaseFlorence Wong
Department of Medicine, Toronto General Hospital, University of Toronto, Toronto, Ontario, Canada
Ann Hepatol 5:5-15. 2006..All patients who require a TIPS for treatment of complications of cirrhosis should be referred for consideration of liver transplant... - Miscellaneous indications for transjugular intrahepatic portosystemic stent-shuntGeorge Therapondos
Division of Gastroenterology, Department of Medicine, University of Toronto, Toronto General Hospital, Toronto, Ontario, Canada
Eur J Gastroenterol Hepatol 18:1161-6. 2006.... 
Diagnosis, prevention and treatment of hepatorenal syndrome in cirrhosisFrancesco Salerno
Department of Internal Medicine, Policlinico IRCCS San Donato, University of Milan, Via Morandi, 30, 20097 San Donato (MI, Italy
Gut 56:1310-8. 2007
Acute kidney injury in decompensated cirrhosisCynthia D Tsien
Division of Gastroenterology, Department of Medicine, Toronto General Hospital, University of Toronto, Toronto, Ontario, Canada
Gut 62:131-7. 2013..It is unclear whether milder degrees of acute kidney injury (AKI), defined as a serum creatinine increase of over 26.4 μmol/l (0.3 mg/dl) or by 50% from baseline, also has a negative impact on patient outcomes...- Recent advances in our understanding of hepatorenal syndromeFlorence Wong
Toronto General Hospital, University of Toronto, 200 Elizabeth Street, Toronto, ON M5G 2C4, Canada
Nat Rev Gastroenterol Hepatol 9:382-91. 2012..In general, patients who have had >8-12 weeks of pretransplant dialysis should be considered for combined liver-kidney transplantation... - Working Party proposal for a revised classification system of renal dysfunction in patients with cirrhosisFlorence Wong
Department of Medicine, Toronto General Hospital, University of Toronto, Toronto, Ontario M5G2C4, Canada
Gut 60:702-9. 2011..Therefore, there is a need for a newer classification to include both functional and structural renal diseases... - Liver and kidney diseasesFlorence Wong
Department of Medicine, Division of Gastroenterology, Toronto General Hospital, University of Toronto, 200 Elizabeth Street, Room 220, 9th Floor, Eaton Wing, M5G 2C4, ON, Canada
Clin Liver Dis 6:981-1011. 2002..The involvement of the liver and kidney in systemic conditions is common and adds to the morbidity and mortality of patients... - The role of liver biopsy in the management of patients with liver diseaseFlorence Wong
Department of Medicine, Toronto General Hospital, University of Toronto, Canada
Can J Gastroenterol 17:651-4. 2003..Prognostic information can be obtained in patients with this disorder, as well as in those with alcoholic liver disease and viral hepatitis, and liver biopsy can be used as a guide to their management... - Midodrine, octreotide, albumin, and TIPS in selected patients with cirrhosis and type 1 hepatorenal syndromeFlorence Wong
Division of Gastroenterology, Department of Medicine, Toronto General Hospital, University of Toronto, Toronto, Ontario, Canada
Hepatology 40:55-64. 2004..In conclusion, TIPS is an effective treatment for type 1 HRS in suitable patients with cirrhosis and ascites, following the improvement of renal function with combination therapy of midodrine, octreotide, and albumin... - Molecular adsorbent recirculating system is ineffective in the management of type 1 hepatorenal syndrome in patients with cirrhosis with ascites who have failed vasoconstrictor treatmentFlorence Wong
Division of Gastroenterology, Department of Medicine, University of Toronto, 9N 983 Toronto General Hospital, 200 Elizabeth Street, Toronto M5G 2C4, Ontario, Canada
Gut 59:381-6. 2010..Molecular adsorbent recirculating system (MARS) is a specialised form of dialysis that clears albumin-bound substances, including vasodilators, and therefore can potentially reduce systemic vasodilatation in cirrhosis... - Sepsis in cirrhosis: report on the 7th meeting of the International Ascites ClubF Wong
Division of Gastoenterology, Toronto General Hospital, University of Toronto, Ontario, Canada
Gut 54:718-25. 2005..The use of antibiotics has to be judicious, as their indiscriminate use can lead to antibiotic resistance with potentially disastrous consequences... - Drug insight: the role of albumin in the management of chronic liver diseaseFlorence Wong
Department of Medicine, Toronto General Hospital, 9th Floor, North Wing, Room 983, 200 Elizabeth Street, Toronto, ON M5G 2C4, Canada
Nat Clin Pract Gastroenterol Hepatol 4:43-51. 2007..Efforts should be made to define the indications for albumin use, dose of albumin required and predictors of response, so that patients gain the maximum benefit from its administration... - Management of ascites in cirrhosisFlorence Wong
Department of Medicine, Toronto General Hospital, University of Toronto, Toronto, Ontario, Canada
J Gastroenterol Hepatol 27:11-20. 2012..Potential new treatment options for ascites include the use of various vasoconstrictors, vasopressin V(2) receptor antagonists, or the insertion of a peritoneo-vesical shunt, all of which could possibly improve the management of ascites... - Lack of renal improvement with nonselective endothelin antagonism with tezosentan in type 2 hepatorenal syndromeFlorence Wong
Division of Gastroenterology, Department of Medicine, Toronto General Hospital, University of Toronto, Toronto, Canada
Hepatology 47:160-8. 2008..Caution should be taken in future studies using endothelin receptor antagonists in these patients... - Hepatorenal syndrome: current managementFlorence Wong
Toronto General Hospital, University of Toronto, Ninth Floor, North Wing, Room 983, 200 Elizabeth Street, Toronto M5G 2C4, Ontario, Canada
Curr Gastroenterol Rep 10:22-9. 2008..Liver transplantation corrects many of the pathophysiological abnormalities associated with HRS, and is the best treatment option. Patient outcome is improved further if the renal function is normalized prior to liver transplantation... - Cirrhotic cardiomyopathyFlorence Wong
Department of Medicine, Toronto General Hospital, University of Toronto, 9th Floor, North Wing, Room 983, 200 Elizabeth Street, Toronto, ON, Canada, M5G 2C4
Hepatol Int 3:294-304. 2009..Long-term aldosterone antagonism may help reduce myocardial hypertrophy. Future studies should include further elucidation of pathogenetic mechanisms so as to develop effective treatment strategies... - Effects of a selective vasopressin V2 receptor antagonist, satavaptan, on ascites recurrence after paracentesis in patients with cirrhosisFlorence Wong
Department of Medicine, University of Toronto, Canada
J Hepatol 53:283-90. 2010.... - Renal diseases and the liverFlorence Wong
Department of Medicine, Toronto General Hospital, University of Toronto, 9th Floor, North Wing, Room 983, 200 Elizabeth Street, Toronto M5G 2C4, Ontario, Canada
Clin Liver Dis 15:39-53. 2011..If cirrhosis is present, renal transplant alone is contraindicated; combined liver and kidney transplantation is indicated in patients with end-stage renal disease and advanced cirrhosis... - A vasopressin receptor antagonist (VPA-985) improves serum sodium concentration in patients with hyponatremia: a multicenter, randomized, placebo-controlled trialFlorence Wong
Department of Medicine, Toronto General Hospital, University of Toronto, Canada
Hepatology 37:182-91. 2003..Higher doses of VPA-985 may produce significant dehydration and will require close monitoring with their use... - Brain natriuretic peptide: is it a predictor of cardiomyopathy in cirrhosis?F Wong
Division of Gastroenterology, The Toronto General Hospital, University of Toronto, 200 Elizabeth Street, Toronto M5G 2C4, Ontario, Canada
Clin Sci (Lond) 101:621-8. 2001..Levels of brain natriuretic peptide may prove to be useful as a marker for screening patients with cirrhosis for the presence of cirrhotic cardiomyopathy, and thereby identifying such patients for further investigations... - The pathophysiologic basis for the treatment of cirrhotic ascitesF Wong
Department of Medicine, Division of Gastroenterology, Toronto General Hospital, University of Toronto, Ontario, Canada
Clin Liver Dis 5:819-32. 2001..The ultimate challenge is to use the understanding of the pathophysiology to develop new strategies to prevent the development of ascites in cirrhosis... - The mechanism of improved sodium homeostasis of low-dose losartan in preascitic cirrhosisFlorence Wong
Department of Medicine, Divisions of Gastroenterology and Cardiology, Toronto General Hospital, University of Toronto, Toronto, ON, Canada
Hepatology 35:1449-58. 2002.... - The cardiac response to exercise in cirrhosisF Wong
Division of Gastroenterology, Toronto General Hospital, University of Toronto, Ontario, Canada
Gut 49:268-75. 2001..Impaired exercise capacity and oxygen consumption are common in cirrhosis... - Effects of insulin on renal function, sympathetic nervous activity and forearm blood flow in normal human subjectsF Wong
Department of Medicine, Toronto Hospital, Ont
Clin Invest Med 20:344-53. 1997..To assess fully the vasodilatory and sodium-retaining effects of insulin... - Review: the controversy over the pathophysiology of ascites formation in cirrhosisF Wong
Department of Medicine, Toronto Hospital, University of Toronto, Ontario, Canada
J Gastroenterol Hepatol 12:437-44. 1997.... - Sodium homeostasis with chronic sodium loading in preascitic cirrhosisF Wong
Department of Medicine, Division of Gastroenterology, Toronto General Hospital, University of Toronto, Toronto, Canada
Gut 49:847-51. 2001..Preascitic cirrhotic patients receiving 200 mmol of sodium daily for seven days remain in positive sodium balance. Thereafter, sodium handling is unknown... - Attributions of cause and recurrence in long-term breast cancer survivorsD E Stewart
University Health Network Women s Health Program, University of Toronto, Canada
Psychooncology 10:179-83. 2001..This survey sought to determine to what women survivors of breast cancer attributed the cause and lack of recurrence of their breast cancer, and whether these views were associated with specific health behaviors... - Natriuretic and aquaretic effects of intravenously infused calcium in preascitic human cirrhosis: physiopathological and clinical implicationsG Sansoe
Division of Gastroenterology, Department of Medicine, Toronto General Hospital, 200 Elizabeth Street, Toronto, Ontario, Canada M5G 2C4
Gut 56:1117-23. 2007..Preascitic cirrhosis is characterised by subtle renal sodium retention. Calcium inhibits Na(+)-K(+)-2Cl(-) cotransport in the Henle's loop and could potentially correct sodium-handling abnormalities at that site... - Portopulmonary hypertension in decompensated cirrhosis with refractory ascitesF S Benjaminov
Division of Gastroenterology, Toronto General Hospital, University of Toronto, Toronto, Ontario, Canada
Gut 52:1355-62. 2003..An elevated right atrial pressure >/= 14 mm Hg predicts the presence of PPHTN, which may be helpful in deciding management options in these patients... - Effects of ascites resolution after successful TIPS on nutrition in cirrhotic patients with refractory ascitesJ P Allard
Division of Gastroenterology, Toronto General Hospital, University of Toronto, Ontario, Canada
Am J Gastroenterol 96:2442-7. 2001..CONCLUSION: In cirrhotic patients with refractory ascites, resolution of the ascites after TIPS placement resulted in improvement of several nutritional parameters, especially for body composition... - "What doesn't kill you makes you stronger": an ovarian cancer survivor surveyD E Stewart
University Health Network, University of Toronto, Toronto, Ontario, M5G 2N2, Canada
Gynecol Oncol 83:537-42. 2001..This survey was designed to learn more about the physical health and quality of life of ovarian cancer survivors without known active disease and not on treatment... - New challenge of hepatorenal syndrome: prevention and treatmentF Wong
Division of Gastroenterology, Department of Medicine, The Toronto General Hospital, University of Toronto, Ontario, Canada
Hepatology 34:1242-51. 2001..The challenge now is to use all this information to improve our management of cirrhotic patients to prevent occurrence of HRS in the future... - The effect of single oral low-dose losartan on posture-related sodium handling in post-TIPS ascites-free cirrhosisGeorge Therapondos
Division of Gastroenterology, Department of Medicine, Toronto General Hospital, University of Toronto, Canada
Hepatology 44:640-9. 2006.... - Long-term breast cancer survivors: confidentiality, disclosure, effects on work and insuranceD E Stewart
University Health Network Women s Health Program, 657 Uniuversity Ave, University of Toronto, Toronto, Ontario, Canada M5G 2N2
Psychooncology 10:259-63. 2001..This study sought to determine the experience of Canadian breast cancer survivors with respect to the impact of cancer on confidentiality, work and insurance... - The use of E/A ratio as a predictor of outcome in cirrhotic patients treated with transjugular intrahepatic portosystemic shuntRania Nancy Rabie
The Division of Gastroenterology, Department of Medicine, University of Toronto, Toronto, Canada
Am J Gastroenterol 104:2458-66. 2009..The aim of this study was to assess the utility of E/A ratio, an indicator of diastolic dysfunction, to predict ascites clearance and mortality after transjugular intrahepatic portosystemic stent shunt (TIPS) insertion... - The views of ovarian cancer survivors on its cause, prevention, and recurrenceD E Stewart
University Health Network Women's Health Program, University of Toronto, Ontario, Canada
Medscape Womens Health 6:5. 2001..This may assist in framing the ongoing management of patients in personally meaningful ways, which may increase adherence to a healthy lifestyle, engender a sense of control, and improve quality of life... - Renal dysfunction in cirrhosis: diagnosis, treatment and preventionElaine Yeung
Department of Medicine, Division of Gastroenterology, Toronto General Hospital, University of Toronto, Toronto, Ontario, Canada
MedGenMed 6:9. 2004 - Clinical recommendations for the use of recombinant human erythropoietin in patients with hepatitis C virus being treated with ribavirinMorris Sherman
Toronto General Hospital, University of Toronto, Toronto, Canada
Can J Gastroenterol 20:479-85. 2006.... - Sustained response after a 2-year course of lamivudine treatment of hepatitis B e antigen-negative chronic hepatitis BS K Fung
Department of Medicine, University of Toronto, Toronto, Ont, Canada
J Viral Hepat 11:432-8. 2004..Reinstitution of lamivudine resulted in prompt virological and biochemical responses. Our study demonstrates that a sustained response can be achieved after a 2-year course of lamivudine in a subset of patients with e-CHB... - Percutaneous ethanol injection of unresectable medium-to-large-sized hepatomas using a multipronged needle: efficacy and safetyC S Ho
Department of Medical Imaging, University of Toronto, University Health Network and Mt Sinai Hospital, Toronto, Canada
Cardiovasc Intervent Radiol 30:241-7. 2007..PEI with a multipronged needle is a new, safe, and efficacious method in treating medium-to-large-sized hepatocellular carcinoma under conscious sedation. Its survival benefits require further investigations... - Concentrations and chiral signatures of POPs in soils and sediments: a comparative urban versus rural study in Canada and UKF Wong
Science and Technology Branch, Environment Canada, 4905 Dufferin St, Toronto, ON, Canada M3H 5T4
Chemosphere 74:404-11. 2009..However, no significant correlation was observed between EE% of any of the chiral chemicals and contaminant levels in the Toronto soils... - Prophylaxis of radiation-associated mucositis in conventionally treated patients with head and neck cancer: a double-blind, phase III, randomized, controlled trial evaluating the clinical efficacy of an antimicrobial lozenge using a validated mucositis scS El-Sayed
Ottawa Regional Cancer Centre, Ottawa, Ontario, Canada
J Clin Oncol 20:3956-63. 2002.... - Radiation induced mucositis: co-ordinating a research agendaJ R Wright
Department of Radiation Oncology, Hamilton Regional Cancer Center, Cancer Care Ontario, Hamilton, Ontario, Canada
Clin Oncol (R Coll Radiol) 15:473-7. 2003..Any additional information needed before the launch of any potential trial was also requested. In this paper, we will review and summarise the outcomes from the radiation-induced mucositis sessions... - Cirrhotic cardiomyopathy: does it contribute to chronic fatigue and decreased health-related quality of life in cirrhosis?Nigel Girgrah
Department of Medicine, Toronto General Hospital, University Health Network, University of Toronto, Ontario, Canada
Can J Gastroenterol 17:545-51. 2003..The presence of cirrhotic cardiomyopathy and the attendant poor cardiac response to physical stress may affect HRQoL and contribute to fatigue in these patients... - Medical management of ascitesWesley Leung
University of Toronto, Toronto General Hospital, Department of Medicine, Ontario, Canada
Expert Opin Pharmacother 12:1269-83. 2011..Recognition of refractory ascites allows for the use of second-line treatments. All patients with cirrhosis and ascites should be considered for liver transplantation... - Hyponatremia in cirrhosis: Results of a patient population surveyPaolo Angeli
Department of Clinical and Experimental Medicine, University of Padova, Padova, Italy
Hepatology 44:1535-42. 2006..In conclusion, low serum sodium levels in cirrhosis are associated with severe ascites and high frequency of hepatic encephalopathy, spontaneous bacterial peritonitis, and hepatorenal syndrome... - The North American Study for the Treatment of Refractory AscitesArun J Sanyal
Department of Internal Medicine, Virginia Commonwealth University Health System, Richmond, Virginia, USA
Gastroenterology 124:634-41. 2003..The clinical utility of transjugular intrahepatic portosystemic shunts (TIPS) vis-à-vis total paracentesis in the management of refractory ascites is unclear... - The natural history and management of hepatorenal disorders: from pre-ascites to hepatorenal syndromeLaurie Blendis
Sackler School of Medicine, University of Tel Aviv, Israel
Clin Med 3:154-9. 2003..However, recent non-controlled studies indicate exciting possibilities of medical therapy reversing HRS... - Does losartan work after all?Laurence M Blendis
Am J Gastroenterol 98:1222-4. 2003 - Regarding the letter in response to our review: the management of cirrhotic ascitesElain Yeung
MedGenMed 4:18; author reply 19. 2002 - Transjugular intrahepatic portosystemic shunt for refractory ascites: a meta-analysis of individual patient dataFrancesco Salerno
Department of Internal Medicine, IRCCS Policlinico San Donato, University of Milan, Milan, Italy
Gastroenterology 133:825-34. 2007..The aim of this study was to compare the effects of TIPS and large-volume paracentesis in cirrhotic patients with refractory ascites by means of meta-analysis of individual patient data from 4 randomized controlled trials... - A 1-year trial of telbivudine, lamivudine, and the combination in patients with hepatitis B e antigen-positive chronic hepatitis BChing Lung Lai
University of Hong Kong, China
Gastroenterology 129:528-36. 2005..A previous 4-week trial of telbivudine in patients with chronic hepatitis B indicated marked antiviral effects with good tolerability, leading to the present 1-year phase 2b trial... - Effects of satavaptan, a selective vasopressin V(2) receptor antagonist, on ascites and serum sodium in cirrhosis with hyponatremia: a randomized trialPere Gines
Hospital Clinic, University of Barcelona, Institut d Investigacions Biomédiques August Pi Sunyer IDIBAPS, Centro de Investigacion Biomedica en Red de Enfermedades Hepaticas y Digestivas CIBERehd, Barcelona, Catalunya, Spain
Hepatology 48:204-13. 2008..CONCLUSION: The V(2) receptor antagonist satavaptan improves the control of ascites and increases serum sodium in patients with cirrhosis, ascites, and hyponatremia under diuretic treatment... - Prevention of varices rebleeding: are drugs better after all?Laurie Blendis
Gastroenterology 122:832-3. 2002 - Sympathetic hyperactivity in pre-ascitesLaurie Blendis
Gastroenterology 122:1538-40; discussion 1540. 2002 - Portopulmonary hypertension: an increasingly important complication of cirrhosisLaurie Blendis
Gastroenterology 125:622-4. 2003 - The management of ascites in cirrhosis: report on the consensus conference of the International Ascites ClubKevin P Moore
Centre for Hepatology, Royal Free and University College Medical School, UCL, London, United Kingdom
Hepatology 38:258-66. 2003..Liver transplantation should be considered for all ascitic patients, and this should preferably be performed prior to the development of renal dysfunction to prevent further compromise of their prognosis... - Excess nitric oxide in preascites: another piece in the puzzleLaurie Blendis
Am J Gastroenterol 97:2167-9. 2002