Research Topics
Species | Albert Hung Choy WongSummaryAffiliation: University of Toronto Country: Canada Publications
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Publications
Schizophrenia: from phenomenology to neurobiologyAlbert Hung Choy Wong
Centre for Addiction and Mental Health, 250 College Street, M5T 1R8, Toronto, Ont, Canada
Neurosci Biobehav Rev 27:269-306. 2003..These broad findings represent the distillation of a large body of disparate data, but firm and specific findings are sparse, and much about schizophrenia remains unknown...
Abnormal interneuron development in disrupted-in-schizophrenia-1 L100P mutant miceFrankie Hf Lee
Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, 250 College Street, Toronto, ON, M5T 1R8, Canada
Mol Brain 6:20. 2013..In this study, we analyzed interneuron histology in the Disc1-L100P single point mutation mouse, that was previously shown to have behavioral abnormalities and cortical developmental defects related to schizophrenia...- Genetic and post-mortem mRNA analysis of the 14-3-3 genes that encode phosphoserine/threonine-binding regulatory proteins in schizophrenia and bipolar disorderAlbert H C Wong
Centre for Addiction and Mental Health, Faculty of Medicine, University of Toronto, Canada
Schizophr Res 78:137-46. 2005..The 14-3-3 genes code for a family of proteins that bind to and regulate other proteins, and they modulate neurodevelopment, cell-division, signal transduction and gene transcription... - Cortical gene expression in the neonatal ventral-hippocampal lesion rat modelAlbert H C Wong
Department of Psychiatry, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada
Schizophr Res 77:261-70. 2005..None of these genes has been extensively studied in schizophrenia, and further work with post-mortem tissue and genetic studies are ongoing... - Herbal remedies in psychiatric practiceA H Wong
Clarke Institute of Psychiatry, Faculty of Medicine, University of Toronto, Ontario, Canada
Arch Gen Psychiatry 55:1033-44. 1998..More research is required for most of the herbs reviewed, but the information published to date is still of clinical interest in diagnosing, counseling, and treating patients who may be taking botanical remedies... - Dopamine receptor gene transfer into rat striatum using a recombinant adenoviral vector: rotational behaviourA H Wong
Department of Psychiatry, Faculty of Medicine, University of Toronto, Ontario, Canada
Neurosci Lett 291:135-8. 2000.... - Polymorphisms in dopamine receptors: what do they tell us?A H Wong
Centre for Addiction and Mental Health, 250 College Street, M5T 1R8, Toronto, ON, Canada
Eur J Pharmacol 410:183-203. 2000..Further insight into the pharmacogenetics of dopamine receptors may require not just more studies, but novel approaches to the study of complex genetic traits and diseases... - N-methyl-D-aspartate receptor NR1 subunit gene (GRIN1) in schizophrenia: TDT and case-control analysesLivia Martucci
Neurogenetics Section, CAMH, Clarke Division, University of Toronto, Toronto, Ontario, Canada
Am J Med Genet B Neuropsychiatr Genet 119:24-7. 2003..42, P-value = 0.659; GRIN1/10, F[df = 2] = 0.16, P-value = 0.853. We are currently collecting additional samples to increase the power of the analyses... - Parent-of-origin effect and genomic imprinting of the HTR2A receptor gene T102C polymorphism in psychosisVincenzo De Luca
Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada
Psychiatry Res 151:243-8. 2007.... - Association between schizophrenia and the syntaxin 1A geneAlbert H C Wong
Centre for Addiction and Mental Health, Toronto, Ontario, Canada
Biol Psychiatry 56:24-9. 2004..Both microarray and candidate molecule studies have demonstrated that protein and mRNA expression of syntaxin and other genes involved in synaptic function are altered in the cerebral cortex of patients with schizophrenia... - Reduced prefrontal cortex DARPP-32 mRNA in completed suicide victims with schizophreniaLaura A Feldcamp
Department of Pharmacology, University of Toronto, 250 College St, M5T1R8, Toronto, Canada
Schizophr Res 103:192-200. 2008..Work in a larger sample is needed to confirm these findings... - Differential expression and parent-of-origin effect of the 5-HT2A receptor gene C102T polymorphism: analysis of suicidality in schizophrenia and bipolar disorderVincenzo De Luca
Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada
Am J Med Genet B Neuropsychiatr Genet 144:370-4. 2007..No association between the 5-HT2A C102T polymorphism and suicidal behavior in major psychoses was detected with the transmission/disequilibrium test (TDT)... 
Kava: a test case for Canada's new approach to natural health productsHeather S Boon
Faculty of Pharmacy, University of Toronto, Toronto, Ont
CMAJ 169:1163-4. 2003- N-methyl-D-aspartate receptor NR2B subunit gene GRIN2B in schizophrenia and bipolar disorder: Polymorphisms and mRNA levelsLivia Martucci
Neurogenetics Section, CAMH, Clarke Division, University of Toronto, R 31, 250 College Street, Toronto ON, Canada M5T 1R8
Schizophr Res 84:214-21. 2006..005). GRIN2B expression levels in schizophrenia, bipolar disorder and controls were not significantly different. The genetic findings suggest a role for GRIN2B in schizophrenia and bipolar disorder... - Association analyses of the DAOA/G30 and D-amino-acid oxidase genes in schizophrenia: further evidence for a role in schizophreniaTakahiro Shinkai
Center for Addiction and Mental Health, Department of Psychiatry, University of Toronto, Toronto, Ontario, M5T 1R8, Canada, and Wakato Hospital, Kitakyushu, Japan
Neuromolecular Med 9:169-77. 2007..Further research is warranted to determine the functional variation underlying these findings and to relate this to the pathophysiology of schizophrenia... - Methylation and QTDT analysis of the 5-HT2A receptor 102C allele: analysis of suicidality in major psychosisVincenzo De Luca
Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, 250 College Road, Toronto, Ontario, Canada
J Psychiatr Res 43:532-7. 2009..This result suggests that methylation of the 102C allele does not influence completed suicide... - Gene expression of tryptophan hydroxylase 2 in post-mortem brain of suicide subjectsVincenzo De Luca
Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada
Int J Neuropsychopharmacol 9:21-5. 2006..Further investigation of TPH2 gene expression is needed to clarify the potential role of this gene in the pathophysiology of suicide... - Microarray analysis of the developing cortexMawahib O Semeralul
Department of Pharmacology, Faculty of Medicine, University of Toronto, Ontario, Canada
J Neurobiol 66:1646-58. 2006.... - Evidence of association between smoking and alpha7 nicotinic receptor subunit gene in schizophrenia patientsVincenzo De Luca
Neurogenetics Section, Clarke Site, Centre for Addiction and Mental Health, Department of Psychiatry, Toronto, Ontario, Canada
Neuropsychopharmacology 29:1522-6. 2004..37, 3 df, p=0.015). Although this novel finding requires replication, it suggests that further study into the relationship between schizophrenia and nicotine system genes is warranted... - Tryptophan hydroxylase 2 gene expression and promoter polymorphisms in bipolar disorder and schizophreniaVincenzo De Luca
Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, Room 711, 250 College Street, Toronto, ON M5T 1R8, Canada
Psychopharmacology (Berl) 183:378-82. 2005..024). Further investigations of Tph2 are needed to clarify the potential role of this gene in the pathophysiology of bipolar disorder... - Serine racemase is associated with schizophrenia susceptibility in humans and in a mouse modelViviane Labrie
Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
Hum Mol Genet 18:3227-43. 2009..Furthermore, analysis of SRR genetic variants in humans identified a robust association with schizophrenia. This study demonstrates that aberrant Srr function and diminished d-serine may contribute to schizophrenia pathogenesis... - DNA methylation profiles in monozygotic and dizygotic twinsZachary A Kaminsky
Centre for Addiction and Mental Health, Toronto, Ontario M5T 1R8, Canada
Nat Genet 41:240-5. 2009.... - Phosphodiesterase 4B genetic variants are not associated with antipsychotic-induced tardive dyskinesiaRenan P Souza
Centre for Addiction and Mental Health, University of Toronto, Toronto, Ontario, Canada
Int Clin Psychopharmacol 25:264-9. 2010..None of these results survived correction for multiple testing. Overall, our results do not support a genetic association between tardive dyskinesia and PDE4B... - No association between the Pro197Leu polymorphism in the glutathione peroxidase (GPX1) gene and schizophreniaTakahiro Shinkai
Neurogenetics Section, Centre for Addiction and Mental Health, Clarke Division, Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada
Psychiatr Genet 14:177-80. 2004..The aim of this study is to examine whether a potentially functional polymorphism, a proline (Pro) to leucine (Leu) substitution at codon 197 (Pro197Leu) of the human GPX1 gene, is associated with susceptibility to schizophrenia... - Analysis of BDNF Val66Met allele-specific mRNA levels in bipolar disorderVincenzo De Luca
Neurogenetics, Centre for Addiction and Mental Health, Toronto, ON, Canada
Neurosci Lett 441:229-32. 2008..The Val/Met ratio was much lower in the brain vs. B lymphoblasts. These data do not support a role for genomic imprinting as a modifier of the contribution of BDNF gene to risk of susceptibility to BD... - Phenotypic differences in genetically identical organisms: the epigenetic perspectiveAlbert H C Wong
The Centre for Addiction and Mental Health, Department of Psychiatry, Toronto, Ontario, Canada
Hum Mol Genet 14:R11-8. 2005.... - The dopamine D4 receptors and mechanisms of antipsychotic atypicalityAlbert H C Wong
Laboratory of Molecular Neurobiology, Centre for Addiction and Mental Health, University of Toronto, Toronto, ON, Canada M5T 1R8
Prog Neuropsychopharmacol Biol Psychiatry 27:1091-9. 2003..In this review, the authors outline some recent developments that provide insight into D4 receptor physiology, function and its possible relationship to schizophrenia treatment...