Albert Hung Choy Wong

Summary

Affiliation: University of Toronto
Country: Canada

Publications

  1. ncbi request reprint Schizophrenia: from phenomenology to neurobiology
    Albert Hung Choy Wong
    Centre for Addiction and Mental Health, 250 College Street, M5T 1R8, Toronto, Ont, Canada
    Neurosci Biobehav Rev 27:269-306. 2003
  2. pmc Abnormal interneuron development in disrupted-in-schizophrenia-1 L100P mutant mice
    Frankie H F Lee
    Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada
    Mol Brain 6:20. 2013
  3. ncbi request reprint Genetic and post-mortem mRNA analysis of the 14-3-3 genes that encode phosphoserine/threonine-binding regulatory proteins in schizophrenia and bipolar disorder
    Albert H C Wong
    Centre for Addiction and Mental Health, Faculty of Medicine, University of Toronto, Canada
    Schizophr Res 78:137-46. 2005
  4. ncbi request reprint Cortical gene expression in the neonatal ventral-hippocampal lesion rat model
    Albert H C Wong
    Department of Psychiatry, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada
    Schizophr Res 77:261-70. 2005
  5. ncbi request reprint Herbal remedies in psychiatric practice
    A H Wong
    Clarke Institute of Psychiatry, Faculty of Medicine, University of Toronto, Ontario, Canada
    Arch Gen Psychiatry 55:1033-44. 1998
  6. ncbi request reprint Dopamine receptor gene transfer into rat striatum using a recombinant adenoviral vector: rotational behaviour
    A H Wong
    Department of Psychiatry, Faculty of Medicine, University of Toronto, Ontario, Canada
    Neurosci Lett 291:135-8. 2000
  7. ncbi request reprint Polymorphisms in dopamine receptors: what do they tell us?
    A H Wong
    Centre for Addiction and Mental Health, 250 College Street, M5T 1R8, Toronto, ON, Canada
    Eur J Pharmacol 410:183-203. 2000
  8. ncbi request reprint N-methyl-D-aspartate receptor NR1 subunit gene (GRIN1) in schizophrenia: TDT and case-control analyses
    Livia Martucci
    Neurogenetics Section, CAMH, Clarke Division, University of Toronto, Toronto, Ontario, Canada
    Am J Med Genet B Neuropsychiatr Genet 119:24-7. 2003
  9. ncbi request reprint Parent-of-origin effect and genomic imprinting of the HTR2A receptor gene T102C polymorphism in psychosis
    Vincenzo De Luca
    Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada
    Psychiatry Res 151:243-8. 2007
  10. ncbi request reprint Association between schizophrenia and the syntaxin 1A gene
    Albert H C Wong
    Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Biol Psychiatry 56:24-9. 2004

Collaborators

Detail Information

Publications27

  1. ncbi request reprint Schizophrenia: from phenomenology to neurobiology
    Albert Hung Choy Wong
    Centre for Addiction and Mental Health, 250 College Street, M5T 1R8, Toronto, Ont, Canada
    Neurosci Biobehav Rev 27:269-306. 2003
    ..These broad findings represent the distillation of a large body of disparate data, but firm and specific findings are sparse, and much about schizophrenia remains unknown...
  2. pmc Abnormal interneuron development in disrupted-in-schizophrenia-1 L100P mutant mice
    Frankie H F Lee
    Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada
    Mol Brain 6:20. 2013
    ..In this study, we analyzed interneuron histology in the Disc1-L100P single point mutation mouse, that was previously shown to have behavioral abnormalities and cortical developmental defects related to schizophrenia...
  3. ncbi request reprint Genetic and post-mortem mRNA analysis of the 14-3-3 genes that encode phosphoserine/threonine-binding regulatory proteins in schizophrenia and bipolar disorder
    Albert H C Wong
    Centre for Addiction and Mental Health, Faculty of Medicine, University of Toronto, Canada
    Schizophr Res 78:137-46. 2005
    ..The 14-3-3 genes code for a family of proteins that bind to and regulate other proteins, and they modulate neurodevelopment, cell-division, signal transduction and gene transcription...
  4. ncbi request reprint Cortical gene expression in the neonatal ventral-hippocampal lesion rat model
    Albert H C Wong
    Department of Psychiatry, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada
    Schizophr Res 77:261-70. 2005
    ..None of these genes has been extensively studied in schizophrenia, and further work with post-mortem tissue and genetic studies are ongoing...
  5. ncbi request reprint Herbal remedies in psychiatric practice
    A H Wong
    Clarke Institute of Psychiatry, Faculty of Medicine, University of Toronto, Ontario, Canada
    Arch Gen Psychiatry 55:1033-44. 1998
    ..More research is required for most of the herbs reviewed, but the information published to date is still of clinical interest in diagnosing, counseling, and treating patients who may be taking botanical remedies...
  6. ncbi request reprint Dopamine receptor gene transfer into rat striatum using a recombinant adenoviral vector: rotational behaviour
    A H Wong
    Department of Psychiatry, Faculty of Medicine, University of Toronto, Ontario, Canada
    Neurosci Lett 291:135-8. 2000
    ....
  7. ncbi request reprint Polymorphisms in dopamine receptors: what do they tell us?
    A H Wong
    Centre for Addiction and Mental Health, 250 College Street, M5T 1R8, Toronto, ON, Canada
    Eur J Pharmacol 410:183-203. 2000
    ..Further insight into the pharmacogenetics of dopamine receptors may require not just more studies, but novel approaches to the study of complex genetic traits and diseases...
  8. ncbi request reprint N-methyl-D-aspartate receptor NR1 subunit gene (GRIN1) in schizophrenia: TDT and case-control analyses
    Livia Martucci
    Neurogenetics Section, CAMH, Clarke Division, University of Toronto, Toronto, Ontario, Canada
    Am J Med Genet B Neuropsychiatr Genet 119:24-7. 2003
    ..42, P-value = 0.659; GRIN1/10, F[df = 2] = 0.16, P-value = 0.853. We are currently collecting additional samples to increase the power of the analyses...
  9. ncbi request reprint Parent-of-origin effect and genomic imprinting of the HTR2A receptor gene T102C polymorphism in psychosis
    Vincenzo De Luca
    Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada
    Psychiatry Res 151:243-8. 2007
    ....
  10. ncbi request reprint Association between schizophrenia and the syntaxin 1A gene
    Albert H C Wong
    Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Biol Psychiatry 56:24-9. 2004
    ..Both microarray and candidate molecule studies have demonstrated that protein and mRNA expression of syntaxin and other genes involved in synaptic function are altered in the cerebral cortex of patients with schizophrenia...
  11. doi request reprint Reduced prefrontal cortex DARPP-32 mRNA in completed suicide victims with schizophrenia
    Laura A Feldcamp
    Department of Pharmacology, University of Toronto, 250 College St, M5T1R8, Toronto, Canada
    Schizophr Res 103:192-200. 2008
    ..Work in a larger sample is needed to confirm these findings...
  12. ncbi request reprint Differential expression and parent-of-origin effect of the 5-HT2A receptor gene C102T polymorphism: analysis of suicidality in schizophrenia and bipolar disorder
    Vincenzo De Luca
    Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada
    Am J Med Genet B Neuropsychiatr Genet 144:370-4. 2007
    ..No association between the 5-HT2A C102T polymorphism and suicidal behavior in major psychoses was detected with the transmission/disequilibrium test (TDT)...
  13. pmc Kava: a test case for Canada's new approach to natural health products
    Heather S Boon
    Faculty of Pharmacy, University of Toronto, Toronto, Ont
    CMAJ 169:1163-4. 2003
  14. ncbi request reprint N-methyl-D-aspartate receptor NR2B subunit gene GRIN2B in schizophrenia and bipolar disorder: Polymorphisms and mRNA levels
    Livia Martucci
    Neurogenetics Section, CAMH, Clarke Division, University of Toronto, R 31, 250 College Street, Toronto ON, Canada M5T 1R8
    Schizophr Res 84:214-21. 2006
    ..005). GRIN2B expression levels in schizophrenia, bipolar disorder and controls were not significantly different. The genetic findings suggest a role for GRIN2B in schizophrenia and bipolar disorder...
  15. ncbi request reprint Association analyses of the DAOA/G30 and D-amino-acid oxidase genes in schizophrenia: further evidence for a role in schizophrenia
    Takahiro Shinkai
    Center for Addiction and Mental Health, Department of Psychiatry, University of Toronto, Toronto, Ontario, M5T 1R8, Canada, and Wakato Hospital, Kitakyushu, Japan
    Neuromolecular Med 9:169-77. 2007
    ..Further research is warranted to determine the functional variation underlying these findings and to relate this to the pathophysiology of schizophrenia...
  16. doi request reprint Methylation and QTDT analysis of the 5-HT2A receptor 102C allele: analysis of suicidality in major psychosis
    Vincenzo De Luca
    Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, 250 College Road, Toronto, Ontario, Canada
    J Psychiatr Res 43:532-7. 2009
    ..This result suggests that methylation of the 102C allele does not influence completed suicide...
  17. ncbi request reprint Gene expression of tryptophan hydroxylase 2 in post-mortem brain of suicide subjects
    Vincenzo De Luca
    Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada
    Int J Neuropsychopharmacol 9:21-5. 2006
    ..Further investigation of TPH2 gene expression is needed to clarify the potential role of this gene in the pathophysiology of suicide...
  18. ncbi request reprint Microarray analysis of the developing cortex
    Mawahib O Semeralul
    Department of Pharmacology, Faculty of Medicine, University of Toronto, Ontario, Canada
    J Neurobiol 66:1646-58. 2006
    ....
  19. ncbi request reprint Evidence of association between smoking and alpha7 nicotinic receptor subunit gene in schizophrenia patients
    Vincenzo De Luca
    Neurogenetics Section, Clarke Site, Centre for Addiction and Mental Health, Department of Psychiatry, Toronto, Ontario, Canada
    Neuropsychopharmacology 29:1522-6. 2004
    ..37, 3 df, p=0.015). Although this novel finding requires replication, it suggests that further study into the relationship between schizophrenia and nicotine system genes is warranted...
  20. ncbi request reprint Tryptophan hydroxylase 2 gene expression and promoter polymorphisms in bipolar disorder and schizophrenia
    Vincenzo De Luca
    Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, Room 711, 250 College Street, Toronto, ON M5T 1R8, Canada
    Psychopharmacology (Berl) 183:378-82. 2005
    ..024). Further investigations of Tph2 are needed to clarify the potential role of this gene in the pathophysiology of bipolar disorder...
  21. pmc Serine racemase is associated with schizophrenia susceptibility in humans and in a mouse model
    Viviane Labrie
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
    Hum Mol Genet 18:3227-43. 2009
    ..Furthermore, analysis of SRR genetic variants in humans identified a robust association with schizophrenia. This study demonstrates that aberrant Srr function and diminished d-serine may contribute to schizophrenia pathogenesis...
  22. doi request reprint DNA methylation profiles in monozygotic and dizygotic twins
    Zachary A Kaminsky
    Centre for Addiction and Mental Health, Toronto, Ontario M5T 1R8, Canada
    Nat Genet 41:240-5. 2009
    ....
  23. doi request reprint Phosphodiesterase 4B genetic variants are not associated with antipsychotic-induced tardive dyskinesia
    Renan P Souza
    Centre for Addiction and Mental Health, University of Toronto, Toronto, Ontario, Canada
    Int Clin Psychopharmacol 25:264-9. 2010
    ..None of these results survived correction for multiple testing. Overall, our results do not support a genetic association between tardive dyskinesia and PDE4B...
  24. ncbi request reprint No association between the Pro197Leu polymorphism in the glutathione peroxidase (GPX1) gene and schizophrenia
    Takahiro Shinkai
    Neurogenetics Section, Centre for Addiction and Mental Health, Clarke Division, Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada
    Psychiatr Genet 14:177-80. 2004
    ..The aim of this study is to examine whether a potentially functional polymorphism, a proline (Pro) to leucine (Leu) substitution at codon 197 (Pro197Leu) of the human GPX1 gene, is associated with susceptibility to schizophrenia...
  25. doi request reprint Analysis of BDNF Val66Met allele-specific mRNA levels in bipolar disorder
    Vincenzo De Luca
    Neurogenetics, Centre for Addiction and Mental Health, Toronto, ON, Canada
    Neurosci Lett 441:229-32. 2008
    ..The Val/Met ratio was much lower in the brain vs. B lymphoblasts. These data do not support a role for genomic imprinting as a modifier of the contribution of BDNF gene to risk of susceptibility to BD...
  26. ncbi request reprint Phenotypic differences in genetically identical organisms: the epigenetic perspective
    Albert H C Wong
    The Centre for Addiction and Mental Health, Department of Psychiatry, Toronto, Ontario, Canada
    Hum Mol Genet 14:R11-8. 2005
    ....
  27. ncbi request reprint The dopamine D4 receptors and mechanisms of antipsychotic atypicality
    Albert H C Wong
    Laboratory of Molecular Neurobiology, Centre for Addiction and Mental Health, University of Toronto, Toronto, ON, Canada M5T 1R8
    Prog Neuropsychopharmacol Biol Psychiatry 27:1091-9. 2003
    ..In this review, the authors outline some recent developments that provide insight into D4 receptor physiology, function and its possible relationship to schizophrenia treatment...