T M S Wolever

Summary

Affiliation: University of Toronto
Country: Canada

Publications

  1. ncbi request reprint Effect of blood sampling schedule and method of calculating the area under the curve on validity and precision of glycaemic index values
    Thomas M S Wolever
    Department of Nutritional Sciences, University of Toronto, Toronto, Ontario, Canada
    Br J Nutr 91:295-301. 2004
  2. doi request reprint Is glycaemic index (GI) a valid measure of carbohydrate quality?
    T M S Wolever
    1 Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada 2 Division of Endocrinology and Metabolism, Department of Medicine, St Michael s Hospital, Toronto, Ontario, Canada 3 Keenan Research Centre of the Li Ka Shing Knowledge Institute, St Michael s Hospital, Toronto, Ontario, Canada 4 Glycemic Index Laboratories, Inc, Toronto, Ontario, Canada
    Eur J Clin Nutr 67:522-31. 2013
  3. doi request reprint Altering source or amount of dietary carbohydrate has acute and chronic effects on postprandial glucose and triglycerides in type 2 diabetes: Canadian trial of Carbohydrates in Diabetes (CCD)
    T M S Wolever
    Department of Nutritional Sciences, University of Toronto, Toronto, Ontario, Canada
    Nutr Metab Cardiovasc Dis 23:227-34. 2013
  4. pmc Effect of adding the novel fiber, PGX®, to commonly consumed foods on glycemic response, glycemic index and GRIP: a simple and effective strategy for reducing post prandial blood glucose levels--a randomized, controlled trial
    Alexandra L Jenkins
    Glycemic Index Laboratories, Inc, Toronto, ON, Canada
    Nutr J 9:58. 2010
  5. doi request reprint Sugars and fat have different effects on postprandial glucose responses in normal and type 1 diabetic subjects
    T M S Wolever
    Department of Nutritional Sciences, University of Toronto, and Keenan Research Centre in the Li Ka Shing Knowledge Institute of St Michael s Hospital, Toronto, Ontario, Canada
    Nutr Metab Cardiovasc Dis 21:719-25. 2011
  6. ncbi request reprint The Canadian Trial of Carbohydrates in Diabetes (CCD), a 1-y controlled trial of low-glycemic-index dietary carbohydrate in type 2 diabetes: no effect on glycated hemoglobin but reduction in C-reactive protein
    Thomas M S Wolever
    Department of Nutritional Sciences, University of Toronto, and the Department of Medicine, St Michael s Hospital, Toronto, Ontario, Canada
    Am J Clin Nutr 87:114-25. 2008
  7. ncbi request reprint High-fiber cereal reduces postprandial insulin responses in hyperinsulinemic but not normoinsulinemic subjects
    Thomas M S Wolever
    Department of Nutritional Sciences, 150 College Street, Room 316, Toronto, Ontario, Canada M5S 3E2
    Diabetes Care 27:1281-5. 2004
  8. ncbi request reprint Measuring the glycemic index of foods: interlaboratory study
    Thomas M S Wolever
    Department of Nutritional Sciences, University of Toronto and Glycemic Index Laboratories, Inc, Toronto, Ontario, Canada
    Am J Clin Nutr 87:247S-257S. 2008
  9. doi request reprint Physicochemical properties of oat β-glucan influence its ability to reduce serum LDL cholesterol in humans: a randomized clinical trial
    Thomas M S Wolever
    Glycemic Index Laboratories Inc, Toronto, Canada
    Am J Clin Nutr 92:723-32. 2010
  10. doi request reprint Low glycaemic index diet and disposition index in type 2 diabetes (the Canadian trial of carbohydrates in diabetes): a randomised controlled trial
    T M S Wolever
    Department of Nutritional Sciences, 150 College St, Toronto, ON, Canada, M5S 3E2
    Diabetologia 51:1607-15. 2008

Collaborators

Detail Information

Publications72

  1. ncbi request reprint Effect of blood sampling schedule and method of calculating the area under the curve on validity and precision of glycaemic index values
    Thomas M S Wolever
    Department of Nutritional Sciences, University of Toronto, Toronto, Ontario, Canada
    Br J Nutr 91:295-301. 2004
    ..The only method whose results agreed reasonably well with the recommended method (ie. within +/-5 %) was AUCcut...
  2. doi request reprint Is glycaemic index (GI) a valid measure of carbohydrate quality?
    T M S Wolever
    1 Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada 2 Division of Endocrinology and Metabolism, Department of Medicine, St Michael s Hospital, Toronto, Ontario, Canada 3 Keenan Research Centre of the Li Ka Shing Knowledge Institute, St Michael s Hospital, Toronto, Ontario, Canada 4 Glycemic Index Laboratories, Inc, Toronto, Ontario, Canada
    Eur J Clin Nutr 67:522-31. 2013
    ....
  3. doi request reprint Altering source or amount of dietary carbohydrate has acute and chronic effects on postprandial glucose and triglycerides in type 2 diabetes: Canadian trial of Carbohydrates in Diabetes (CCD)
    T M S Wolever
    Department of Nutritional Sciences, University of Toronto, Toronto, Ontario, Canada
    Nutr Metab Cardiovasc Dis 23:227-34. 2013
    ..We aimed to explore whether long-term changes in postprandial responses on low-glycemic-index (GI) or low-CHO diets were due to acute or chronic effects in T2DM...
  4. pmc Effect of adding the novel fiber, PGX®, to commonly consumed foods on glycemic response, glycemic index and GRIP: a simple and effective strategy for reducing post prandial blood glucose levels--a randomized, controlled trial
    Alexandra L Jenkins
    Glycemic Index Laboratories, Inc, Toronto, ON, Canada
    Nutr J 9:58. 2010
    ..This study explores whether these reductions are sustained when NVP is added to a range of commonly consumed foods or incorporated into a breakfast cereal...
  5. doi request reprint Sugars and fat have different effects on postprandial glucose responses in normal and type 1 diabetic subjects
    T M S Wolever
    Department of Nutritional Sciences, University of Toronto, and Keenan Research Centre in the Li Ka Shing Knowledge Institute of St Michael s Hospital, Toronto, Ontario, Canada
    Nutr Metab Cardiovasc Dis 21:719-25. 2011
    ..We aimed to determine the effects on glycemic responses and potential risk of hypoglycaemia in type 1 diabetic subjects of replacing half the starch in a meal with sugars, and of adding fat to the low-sugar and high-sugar meals...
  6. ncbi request reprint The Canadian Trial of Carbohydrates in Diabetes (CCD), a 1-y controlled trial of low-glycemic-index dietary carbohydrate in type 2 diabetes: no effect on glycated hemoglobin but reduction in C-reactive protein
    Thomas M S Wolever
    Department of Nutritional Sciences, University of Toronto, and the Department of Medicine, St Michael s Hospital, Toronto, Ontario, Canada
    Am J Clin Nutr 87:114-25. 2008
    ..The optimal source and amount of dietary carbohydrate for managing type 2 diabetes (T2DM) are unknown...
  7. ncbi request reprint High-fiber cereal reduces postprandial insulin responses in hyperinsulinemic but not normoinsulinemic subjects
    Thomas M S Wolever
    Department of Nutritional Sciences, 150 College Street, Room 316, Toronto, Ontario, Canada M5S 3E2
    Diabetes Care 27:1281-5. 2004
    ....
  8. ncbi request reprint Measuring the glycemic index of foods: interlaboratory study
    Thomas M S Wolever
    Department of Nutritional Sciences, University of Toronto and Glycemic Index Laboratories, Inc, Toronto, Ontario, Canada
    Am J Clin Nutr 87:247S-257S. 2008
    ..Many laboratories offer glycemic index (GI) services...
  9. doi request reprint Physicochemical properties of oat β-glucan influence its ability to reduce serum LDL cholesterol in humans: a randomized clinical trial
    Thomas M S Wolever
    Glycemic Index Laboratories Inc, Toronto, Canada
    Am J Clin Nutr 92:723-32. 2010
    ..LDL cholesterol lowering by oat β-glucan may depend on viscosity, which is controlled by the molecular weight (MW) and amount of oat β-glucan solubilized in the intestine (C)...
  10. doi request reprint Low glycaemic index diet and disposition index in type 2 diabetes (the Canadian trial of carbohydrates in diabetes): a randomised controlled trial
    T M S Wolever
    Department of Nutritional Sciences, 150 College St, Toronto, ON, Canada, M5S 3E2
    Diabetologia 51:1607-15. 2008
    ..Since this is a report of secondary analysis on a previously published trial, the results should be considered as hypothesis-generating...
  11. ncbi request reprint Food glycemic index, as given in glycemic index tables, is a significant determinant of glycemic responses elicited by composite breakfast meals
    Thomas M S Wolever
    Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, Canada
    Am J Clin Nutr 83:1306-12. 2006
    ..We hypothesized that these conclusions may be unwarranted because of methodologic considerations...
  12. ncbi request reprint Measuring glycaemic responses: duplicate fasting samples or duplicate measures of one fasting sample?
    Thomas M S Wolever
    Department of Nutritional Sciences, University of Toronto, Toronto, Ontario, Canada M5S 3E2
    Br J Nutr 96:799-802. 2006
    ..Further studies are needed before requiring that two fasting blood samples be taken for determining glycaemic index...
  13. ncbi request reprint Determination of the glycaemic index of foods: interlaboratory study
    T M S Wolever
    Department of Nutritional Sciences, University of Toronto, Toronto, Ontario, Canada
    Eur J Clin Nutr 57:475-82. 2003
    ..Our purpose was to determine the magnitude and sources of variation of the GI values obtained by experienced investigators in different international centres...
  14. ncbi request reprint Long-term effect of varying the source or amount of dietary carbohydrate on postprandial plasma glucose, insulin, triacylglycerol, and free fatty acid concentrations in subjects with impaired glucose tolerance
    Thomas M S Wolever
    Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, and the Clinical Nutrition and Risk Factor Modification Centre, St Michael s Hospital, Ontario, Canada
    Am J Clin Nutr 77:612-21. 2003
    ..Reducing the glycemic load (GL) is considered beneficial for managing insulin resistance. The GL can be reduced either by reducing carbohydrate intake or by reducing the glycemic index (GI)...
  15. doi request reprint Day-to-day variation in glycemic response elicited by white bread is not related to variation in satiety in humans
    Thomas M S Wolever
    Glycemic Index Laboratories, Inc, Toronto, Ontario, Canada
    Appetite 52:654-8. 2009
    ..4480+/-683 mm min, ns). The results were similar for males and females. These results do not support the hypothesis that glycemic responses per se influence feelings of satiety over the 2h period after eating...
  16. ncbi request reprint Variation of postprandial plasma glucose, palatability, and symptoms associated with a standardized mixed test meal versus 75 g oral glucose
    T M Wolever
    Department of Nutritional Sciences, Univeristy of Toronto, Ontario, Canada
    Diabetes Care 21:336-40. 1998
    ....
  17. ncbi request reprint No relationship between carbohydrate intake and effect of acarbose on HbA1c or gastrointestinal symptoms in type 2 diabetic subjects consuming 30-60% of energy from carbohydrate
    T M Wolever
    Department of Nutritional Sciences, University of Toronto, Ontario, Canada
    Diabetes Care 21:1612-8. 1998
    ..To determine the relationship between carbohydrate intake and the effect of acarbose on HbA1c in subjects with type 2 diabetes treated with acarbose alone, acarbose plus sulfonylurea, acarbose plus metformin, or acarbose plus insulin...
  18. ncbi request reprint Dietary carbohydrates and insulin action in humans
    T M Wolever
    Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Canada
    Br J Nutr 83:S97-102. 2000
    ..Thus further work needs to be done before a firm conclusion can be drawn as to the optimal amount and type of dietary carbohydrate for the treatment of the metabolic syndrome...
  19. ncbi request reprint Acarbose raises serum butyrate in human subjects with impaired glucose tolerance
    T M Wolever
    Department of Nutritional Sciences and Medicine, University of Toronto, Ontario, Canada
    Br J Nutr 84:57-61. 2000
    ..These results support the hypothesis that increased colonic butyrate production in human subjects can be detected by an increase in serum butyrate...
  20. doi request reprint The glycaemic index values of foods containing fructose are affected by metabolic differences between subjects
    T M S Wolever
    Glycemic Index Laboratories, Inc, Toronto, Ontario, Canada
    Eur J Clin Nutr 63:1106-14. 2009
    ..We hypothesized that glycaemic index (GI) values are affected by the metabolic differences between subjects for foods containing fructose or fat, but not for starchy foods...
  21. ncbi request reprint High-carbohydrate-low-glycaemic index dietary advice improves glucose disposition index in subjects with impaired glucose tolerance
    Thomas M S Wolever
    Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Canada M5S 3E2
    Br J Nutr 87:477-87. 2002
    ..High-carbohydrate-low-GI dietary advice improved beta-cell function in subjects with IGT, and may, therefore, be useful in the management of IGT...
  22. ncbi request reprint Do colonic short-chain fatty acids contribute to the long-term adaptation of blood lipids in subjects with type 2 diabetes consuming a high-fiber diet?
    Thomas M S Wolever
    Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Ontario, Canada
    Am J Clin Nutr 75:1023-30. 2002
    ..We recently obtained evidence of long-term adaptation of blood lipids to changes in intakes of carbohydrate and fiber in subjects with type 2 diabetes...
  23. ncbi request reprint Low dietary fiber and high protein intakes associated with newly diagnosed diabetes in a remote aboriginal community
    T M Wolever
    Department of Nutritional Sciences and Medicine, University of Toronto, Ontario, Canada
    Am J Clin Nutr 66:1470-4. 1997
    ..These data support Trowell's original dietary-fiber hypothesis that "... dietary fiber depleted starchy foods are conducive to the development of diabetes mellitus in susceptible human genotypes."..
  24. pmc Bioactive oat β-glucan reduces LDL cholesterol in Caucasians and non-Caucasians
    Thomas M S Wolever
    Glycemic Index Laboratories, Inc, Toronto, Ontario, Canada
    Nutr J 10:130. 2011
    ....
  25. doi request reprint The fermentable fibre inulin increases postprandial serum short-chain fatty acids and reduces free-fatty acids and ghrelin in healthy subjects
    Joshua Tarini
    Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, ON M5S 3E2, Canada
    Appl Physiol Nutr Metab 35:9-16. 2010
    ....
  26. ncbi request reprint Acarbose in the treatment of elderly patients with type 2 diabetes
    R G Josse
    Division of Endocrinology and Metabolism, University of Toronto, Ont, Canada
    Diabetes Res Clin Pract 59:37-42. 2003
    ..To study the effect of acarbose, an alpha-glucosidase inhibitor, on glycemic control in elderly patients with type 2 diabetes...
  27. doi request reprint Intravenous acetate elicits a greater free fatty acid rebound in normal than hyperinsulinaemic humans
    J Fernandes
    Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada
    Eur J Clin Nutr 66:1029-34. 2012
    ..The main objectives of this study were to compare peripheral uptake of acetate (AC) in participants with normal (<40 pmol/l, NI) and high (≥ 40 pmol/l, HI) plasma insulin, and the ability of AC to reduce FFA in both the groups...
  28. doi request reprint Inulin increases short-term markers for colonic fermentation similarly in healthy and hyperinsulinaemic humans
    J Fernandes
    Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada
    Eur J Clin Nutr 65:1279-86. 2011
    ....
  29. ncbi request reprint Effects of sucromalt on postprandial responses in human subjects
    A Grysman
    Department of Nutritional Sciences, University of Toronto, Toronto, Ontario, Canada
    Eur J Clin Nutr 62:1364-71. 2008
    ....
  30. doi request reprint Adaptation of colonic fermentation and glucagon-like peptide-1 secretion with increased wheat fibre intake for 1 year in hyperinsulinaemic human subjects
    Kristin R Freeland
    Department of Nutritional Sciences, University of Toronto, Toronto, Ontario, Canada
    Br J Nutr 103:82-90. 2010
    ..Since GLP-1 may increase insulin sensitivity and secretion, these results may provide a mechanism for the epidemiological association between high cereal fibre intake and reduced risk for diabetes...
  31. doi request reprint The hypoglycemic effect of fat and protein is not attenuated by insulin resistance
    Xiaomiao Lan-Pidhainy
    Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, Canada
    Am J Clin Nutr 91:98-105. 2010
    ..The glucose-lowering effect of fat and protein is attenuated or absent in diabetic patients, which suggests that the same may occur in insulin-resistant subjects without diabetes...
  32. doi request reprint Are the glycemic and insulinemic index values of carbohydrate foods similar in healthy control, hyperinsulinemic and type 2 diabetic patients?
    X Lan-Pidhainy
    Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Ontario, Canada
    Eur J Clin Nutr 65:727-34. 2011
    ....
  33. ncbi request reprint Carbohydrate and the regulation of blood glucose and metabolism
    Thomas M S Wolever
    Department of Nutritional Sciences, University of Toronto, Toronto, Ontario, Canada M5S 3E2
    Nutr Rev 61:S40-8. 2003
    ..By contrast, low-GI diets reduce serum FFA and improve glycemic control. Thus, current evidence supports FAO/WHO recommendations to maintain a high-carbohydrate diet and choose low-GI starchy foods...
  34. ncbi request reprint The effects of fat and protein on glycemic responses in nondiabetic humans vary with waist circumference, fasting plasma insulin, and dietary fiber intake
    Elham Moghaddam
    Department of Nutritional Sciences, University of Toronto, Toronto, Ontario M5S 3E2, Canada
    J Nutr 136:2506-11. 2006
    ..These conclusions may not apply to solid meals. Further studies are needed to determine the mechanisms for these effects...
  35. ncbi request reprint L-Rhamnose increases serum propionate in humans
    Janet A Vogt
    University of Toronto, Toronto, Canada
    Am J Clin Nutr 80:89-94. 2004
    ..The unabsorbed sugar lactulose produces mainly acetate when fermented in vitro, whereas L-rhamnose yields propionate...
  36. ncbi request reprint Enhanced food intake regulatory responses after a glucose drink in hyperinsulinemic men
    R Abou Samra
    Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada
    Int J Obes (Lond) 31:1222-31. 2007
    ..To determine the effect of hyperinsulinemia on food intake and plasma concentrations of glucose and food intake regulatory hormones in men after a glucose drink...
  37. ncbi request reprint Tumor necrosis factor alpha -238G>A genotype alters postprandial plasma levels of free fatty acids in obese individuals with type 2 diabetes mellitus
    Bénédicte Fontaine-Bisson
    Department of Nutritional Sciences, University of Toronto, Toronto, Canada
    Metabolism 56:649-55. 2007
    ..19 +/- 1.24 vs 1.97 +/- 0.90, P = .6). Our findings suggest that the -238G>A and -308G>A polymorphisms of TNF-alpha alter circulating free fatty acids and insulin resistance in obese subjects with type 2 diabetes mellitus...
  38. doi request reprint Acute effects of dietary fibre and glycaemic carbohydrate on appetite and food intake in healthy males
    Kristin R Freeland
    The Department of Nutritional Sciences, University of Toronto, Toronto, Canada
    Appetite 52:58-64. 2009
    ..These results suggest that a serving of 41 g insoluble fibre reduces food intake independent of its weight and volume and similar to an equal weight of glucose within 60 min, but this effect is not maintained after 120 min...
  39. ncbi request reprint Pre-operative modification of dietary glycemic index improves pre but not post-operative indices of insulin resistance in patients undergoing coronary artery bypass graft surgery
    Victoria Tully
    Division of Cardiovascular and Thoracic Surgery, St Michael s Hospital, Toronto, Ontario, Canada
    J Am Coll Nutr 27:168-76. 2008
    ..The aim of this study was to determine whether a short term LGI diet would reduce postoperative insulin resistance...
  40. doi request reprint Effect of blood sampling schedule on the ability to discriminate between postprandial glycemic responses
    Janice L Lui
    Department of Nutritional Sciences, University of Toronto, Toronto, Ontario, Canada
    Nutrition 25:1064-6. 2009
    ..The blood glucose responses elicited by foods are often determined using blood samples taken at 15-min intervals. Our objective was to see whether taking blood samples at 10-min intervals affected the results...
  41. doi request reprint Physicochemical properties of beta-glucan in differently processed oat foods influence glycemic response
    Alejandra Regand
    Agriculture and Agri Food Canada, West Guelph, Ontario, Canada
    J Agric Food Chem 57:8831-8. 2009
    ..Characterizing the physicochemical properties of beta-glucan in bioactive foods aids functional food development...
  42. ncbi request reprint Glycemic index of potatoes commonly consumed in North America
    Glen Fernandes
    University of Toronto, Ontario M5S 3E2, Canada
    J Am Diet Assoc 105:557-62. 2005
    ..To determine the effect of variety and cooking method on glycemic response and glycemic index of common North American potatoes...
  43. ncbi request reprint Postprandial lipemia in subjects with the threonine 54 variant of the fatty acid-binding protein 2 gene is dependent on the type of fat ingested
    Paula D N Dworatzek
    Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Ontario, Canada
    Am J Clin Nutr 79:1110-7. 2004
    ..Obese and diabetic T54 carriers have greater postprandial lipemia than do A54 homozygotes. The T54 protein isoform is also associated with increased triacylglycerol secretion in vitro...
  44. ncbi request reprint L-rhamnose and lactulose decrease serum triacylglycerols and their rates of synthesis, but do not affect serum cholesterol concentrations in men
    Janet A Vogt
    Clinical Nutrition and Risk Factor Modification Centre, St Michael s Hospital, Toronto, ON, Canada
    J Nutr 136:2160-6. 2006
    ..Although these data are consistent with inhibition of TGFA synthesis by SCFA, other aspects of the metabolism of these sugars cannot be ruled out as putative agents of their TG-lowering effects...
  45. doi request reprint Acute effects of intravenous and rectal acetate on glucagon-like peptide-1, peptide YY, ghrelin, adiponectin and tumour necrosis factor-alpha
    Kristin R Freeland
    Department of Nutritional Sciences, University of Toronto, Toronto, ON, Canada
    Br J Nutr 103:460-6. 2010
    ..Also, distending the rectum increases PYY, GLP-1, TNF-alpha and ghrelin in hyperinsulinaemic females. Increasing colonic fermentation products, particularly acetate, could yield a new mechanism for modifying weight gain...
  46. ncbi request reprint Inverse association between the effect of carbohydrates on blood glucose and subsequent short-term food intake in young men
    G Harvey Anderson
    Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Ontario, Canada
    Am J Clin Nutr 76:1023-30. 2002
    ..A primary mechanism by which carbohydrates are thought to regulate satiety and food intake is through their effect on blood glucose...
  47. doi request reprint Effect of a low glycaemic index diet on blood glucose in women with gestational hyperglycaemia
    Shannan M Grant
    Department of Nutritional Sciences, University of Toronto, 150 College Street, Toronto, Ontario, M5S 3E2, Canada
    Diabetes Res Clin Pract 91:15-22. 2011
    ..The objectives of this pilot study were to determine the feasibility and effect on glycaemic control of a low-glycaemic-index (GI) diet in women with gestational diabetes or impaired glucose tolerance of pregnancy...
  48. ncbi request reprint Effect of carbohydrate source on post-prandial blood glucose in subjects with type 1 diabetes treated with insulin lispro
    Nadia H Mohammed
    Department of Nutritional Sciences, University of Toronto, Ont, Canada
    Diabetes Res Clin Pract 65:29-35. 2004
    ..Further studies using mixed meals are required to confirm how carbohydrate source affects glycemic responses and occurrence of hypoglycemia in normal meal setting...
  49. ncbi request reprint Cross-sectional and prospective associations between abdominal adiposity and proinsulin concentration
    Anthony J G Hanley
    Department of Public Health Sciences, University of Toronto, Ontario M5S 1A8, Canada
    J Clin Endocrinol Metab 87:77-83. 2002
    ..24, P = 0.03, respectively). These data highlight the detrimental effects of abdominal obesity on beta-cell function, and support the hypothesis that beta-cell dysfunction occurs early in the natural history of glucose intolerance...
  50. ncbi request reprint Low carbohydrate does not mean low glycaemic index!
    Thomas M S Wolever
    Department of Nutritional Sciences, University of Toronto, Toronto, Ontario M5S 3E2 Canada
    Br J Nutr 88:211-2; author reply 213-4. 2002
  51. ncbi request reprint Association of parity with risk of type 2 diabetes and related metabolic disorders
    Anthony J G Hanley
    Department of Public Health Sciences, University of Toronto, Toronto, Canada
    Diabetes Care 25:690-5. 2002
    ..The objective of this study was to investigate the association between parity and risk of glucose intolerance and related metabolic disorders using data from a population-based study in a Native Canadian community...
  52. ncbi request reprint Evaluation of a glucose meter for determining the glycemic responses of foods
    Amogh Velangi
    Department of Nutritional Sciences, University of Toronto, Toronto, ON, Canada M5S 3E2
    Clin Chim Acta 356:191-8. 2005
    ..Glucose meters are convenient for measuring postprandial glycemic responses. However, their performance for this purpose has not been evaluated...
  53. ncbi request reprint Insulin resistance and adiponectin levels in drug-free patients with schizophrenia: A preliminary report
    Tony A Cohn
    Department of Psychiatry, Faculty of Medicine, University of Toronto, Ontario
    Can J Psychiatry 51:382-6. 2006
    ..To compare the insulin sensitivity and adiponectin levels of medication-free patients suffering from schizophrenia or schizoaffective disorder with that of matched healthy volunteers...
  54. pmc Metabolic syndrome and its components as predictors of incident type 2 diabetes mellitus in an Aboriginal community
    Sylvia H Ley
    Department of Nutritional Sciences, University of Toronto, Toronto, Ont
    CMAJ 180:617-24. 2009
    ..We aimed to determine the incidence of type 2 diabetes in an Aboriginal community and to evaluate prospective associations with metabolic syndrome and its components...
  55. pmc Comparable postprandial glucose reductions with viscous fiber blend enriched biscuits in healthy subjects and patients with diabetes mellitus: acute randomized controlled clinical trial
    Alexandra L Jenkins
    Clinical Nutrition and Risk Factor Modification Center, St Michael s Hospital and Li Ka Shing Knowledge Institute, 70 Richmond St E, Toronto, Ontario, Canada
    Croat Med J 49:772-82. 2008
    ..To compare the blood glucose-lowering effect of a highly viscous fiber blend (VFB) added to a starchy snack on postprandial glycemia between healthy participants and participants with diabetes mellitus...
  56. ncbi request reprint L-Rhamnose increases serum propionate after long-term supplementation, but lactulose does not raise serum acetate
    Janet A Vogt
    University of Toronto, Department of Nutritional Sciences, Toronto, ON, Canada
    Am J Clin Nutr 80:1254-61. 2004
    ..It is not known whether short-chain fatty acid concentrations in urine and feces reflect those in blood...
  57. ncbi request reprint Lower diet glycaemic index in African than South Asian men in Trinidad and Tobago
    Thomas M S Wolever
    Department of Nutritional Sciences, University of Toronto, Toronto, Ontario, Canada M5S 3E2
    Int J Food Sci Nutr 53:297-303. 2002
    ..The data collected during this survey will be useful in developing a food frequency questionnaire for use in T&T to allow this hypothesis to be tested more rigorously in this population...
  58. ncbi request reprint Effect of antibiotics as cholesterol-lowering agents
    David J A Jenkins
    Clinical Nutrition and Risk Factor Modification Center, St Michael s Hospital, Toronto, Ontario, Canada M5C 2TC
    Metabolism 54:103-12. 2005
    ....
  59. doi request reprint NF-kappaB -94Ins/Del ATTG polymorphism modifies the association between dietary polyunsaturated fatty acids and HDL-cholesterol in two distinct populations
    Bénédicte Fontaine-Bisson
    Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, Canada
    Atherosclerosis 204:465-70. 2009
    ..05). These findings show that this functional polymorphism in the NF-kB gene modifies the association between PUFA intake and plasma HDL-cholesterol in two distinct populations...
  60. ncbi request reprint Effect of coffee and tea on the glycaemic index of foods: no effect on mean but reduced variability
    Ahmed Aldughpassi
    Department of Nutritional Sciences, University of Toronto, Toronto, Ontario, Canada M5S 3E2
    Br J Nutr 101:1282-5. 2009
    ..water (F(18, 18) = 2.31; P=0.04). We conclude that drinking coffee or tea with test meals does not affect the mean GI value obtained, but may reduce variability and, hence, improve precision...
  61. doi request reprint Genetic variant in the glucose transporter type 2 is associated with higher intakes of sugars in two distinct populations
    Karen M Eny
    Department of Nutritional Sciences, University of Toronto, Toronto, Canada
    Physiol Genomics 33:355-60. 2008
    ..Taken together, our findings show that a genetic variation in GLUT2 is associated with habitual consumption of sugars, suggesting an underlying glucose-sensing mechanism that regulates food intake...
  62. ncbi request reprint Genetic polymorphisms of tumor necrosis factor-alpha modify the association between dietary polyunsaturated fatty acids and fasting HDL-cholesterol and apo A-I concentrations
    Bénédicte Fontaine-Bisson
    Department of Nutritional Sciences and Nutrition, University of Toronto, Toronto, Canada
    Am J Clin Nutr 86:768-74. 2007
    ..Tumor necrosis factor-alpha (TNF-alpha) is a proinflammatory cytokine that can induce hyperlipidemia and is known to be modulated by dietary PUFAs...
  63. doi request reprint Effect of preparation method on the glycaemic index of novel potato clones
    Tara Kinnear
    Department of Nutritional Sciences, University of Toronto, Toronto, Ontario, Canada M5S 3E2
    Food Funct 2:438-44. 2011
    ..However, the mechanism for the effect is not clear: the 2% increase in starch malabsorption seen upon cooling potatoes was not nearly enough to account for the 37% reduction in GI...
  64. ncbi request reprint The TNF-alpha-238G > a single-nucleotide polymorphism protects against memory decline in older adults with type 2 diabetes
    Michael H Chui
    Department of Nutritional Sciences, University of Toronto, Toronto, ON, Canada
    Behav Neurosci 121:619-24. 2007
    ..Therefore, inflammatory mediators may be important modulators of memory function in individuals with T2DM...
  65. ncbi request reprint Fecal acetate is inversely related to acetate absorption from the human rectum and distal colon
    Janet A Vogt
    Department of Nutritional Sciences, University of Toronto, Toronto, Canada
    J Nutr 133:3145-8. 2003
    ..Furthermore, fecal acetate may reflect absorption, rather than production of colonic acetate...
  66. ncbi request reprint Dietary glycemic index and glycemic load, carbohydrate and fiber intake, and measures of insulin sensitivity, secretion, and adiposity in the Insulin Resistance Atherosclerosis Study
    Angela D Liese
    Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, 800 Sumter Street, Columbia, SC 29205, USA
    Diabetes Care 28:2832-8. 2005
    ..We studied the association of digestible carbohydrates, fiber intake, glycemic index, and glycemic load with insulin sensitivity (S(I)), fasting insulin, acute insulin response (AIR), disposition index, BMI, and waist circumference...
  67. ncbi request reprint Glycemic index of common Malaysian fruits
    S Daniel Robert
    Program in Dietetics, School of Health Sciences, Health Campus, Universiti Sains Malaysia, 16150, Kubang Kerian, Kota Bharu Kelantan, Malaysia
    Asia Pac J Clin Nutr 17:35-9. 2008
    ..The validity of these results depends on the accuracy of the data in the food tables upon which the portion sizes tested were based...
  68. ncbi request reprint Glycaemic index of selected staples commonly eaten in the Caribbean and the effects of boiling v. crushing
    D Dan Ramdath
    Department of Preclinical Sciences, Faculty of Medical Sciences, The University of the West Indies, St Augustine, Trinidad and Tobago
    Br J Nutr 91:971-7. 2004
    ..The range of GI between the staples is sufficiently large that health benefits may be accrued by replacing high-GI staples with intermediate-GI staples in the Caribbean diet...
  69. ncbi request reprint The use of glycaemic index tables to predict glycaemic index of breakfast meals
    Jennie C Brand-Miller
    The Human Nutrition Unit School of Molecular and Microbial Biosciences The University of Sydney Sydney, NSW Australia
    Br J Nutr 94:133-4. 2005
  70. ncbi request reprint Glycemic index, glycemic load, and glycemic response are not the same
    Alan W Barclay
    Diabetes Care 28:1839-40. 2005
  71. ncbi request reprint Influence of glycemic index/load on glycemic response, appetite, and food intake in healthy humans
    Thomas M S Wolever
    Diabetes Care 29:474-5; author reply 475-6. 2006
  72. ncbi request reprint Carbohydrate nutrition, glycaemic load, and plasma lipids: the Insulin Resistance Atherosclerosis Study
    Angela D Liese
    Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, 800 Sumter Street, Columbia, SC 29208, USA
    Eur Heart J 28:80-7. 2007
    ..We evaluated the relationship of carbohydrate nutrition and selected food groups with lipids using data from the Insulin Resistance Atherosclerosis Study (IRAS Exam I, 1992-1994)...