Affiliation: University of Toronto
Tsai S, Clemente Casares X, Revelo X, Winer S, Winer D. Are obesity-related insulin resistance and type 2 diabetes autoimmune diseases?. Diabetes. 2015;64:1886-97 pubmed publisher
Revelo X, Tsai S, Lei H, Luck H, Ghazarian M, Tsui H, et al
. Perforin is a novel immune regulator of obesity-related insulin resistance. Diabetes. 2015;64:90-103 pubmed publisher
..The findings support the importance of T-cell function in insulin resistance and suggest that modulation of lymphocyte homeostasis in inflamed VAT is one possible avenue for therapeutic intervention. ..
Winer D, Luck H, Tsai S, Winer S. The Intestinal Immune System in Obesity and Insulin Resistance. Cell Metab. 2016;23:413-26 pubmed publisher
..This review discusses the emerging field of intestinal immunity in obesity-related insulin resistance and how it affects metabolic disease. ..
Luck H, Tsai S, Chung J, Clemente Casares X, Ghazarian M, Revelo X, et al
. Regulation of obesity-related insulin resistance with gut anti-inflammatory agents. Cell Metab. 2015;21:527-42 pubmed publisher
..Thus, the mucosal immune system affects multiple pathways associated with systemic IR and represents a novel therapeutic target in this disease. ..