Affiliation: University of Alberta
- A balanced IL-1β activity is required for host response to Citrobacter rodentium infectionMisagh Alipour
Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada Centre of Excellence for Gastrointestinal Inflammation and Immunity Research CEGIIR, University of Alberta, Edmonton, Alberta, Canada
PLoS ONE 8:e80656. 2013..Together, these findings highlight the importance of balanced cytokine responses as IL-1β improved bacterial clearance in Nlrp3(-/-) mice but increased tissue damage when given to WT mice. ..
- Interleukin-6 is associated with steroid resistance and reflects disease activity in severe pediatric ulcerative colitisEytan Wine
Department of Pediatrics, University of Alberta, Edmonton, AB, Canada Electronic address
J Crohns Colitis 7:916-22. 2013..Predicting response to IVCS to initiate early salvage therapy remains challenging. The aim of this study was to evaluate the role of serum inflammatory cytokines in ASC and determine their predictive utility with IVCS treatment failure...
- Adherent-invasive Escherichia coli, strain LF82 disrupts apical junctional complexes in polarized epitheliaEytan Wine
Research Institute, Hospital for Sick Children, Toronto, Ontario, Canada
BMC Microbiol 9:180. 2009..Therefore, the aim of this study was to delineate the effects of AIEC, strain LF82 (serotype O83:H1) on model polarized epithelial monolayers as a contributor to intestinal injury in IBD...
- Epithelial cell extrusion leads to breaches in the intestinal epitheliumJulia J Liu
Gastroenterology Division, University of Alberta, Edmonton, Alberta, Canada
Inflamm Bowel Dis 19:912-21. 2013..In this study, we sought to determine the mechanism underlying the IEC extrusion that alters the permeability of the gut epithelium...
- Osteopontin mediates Citrobacter rodentium-induced colonic epithelial cell hyperplasia and attaching-effacing lesionsEytan Wine
Pediatric Gastroenterology, University of Alberta, Edmonton, Alberta, Canada
Am J Pathol 177:1320-32. 2010..rodentium infection, indicating that OPN impacts disease pathogenesis through bacterial attachment and altered host immune responses...
- Bacterial infection causes stress-induced memory dysfunction in miceMélanie G Gareau
Cell Biology Program, Research Institute, Hospital for Sick Children, Toronto, ON, Canada
Gut 60:307-17. 2011..Whether intestinal events, such as enteric bacterial infections and bacterial colonisation, exert a reciprocal effect on stress-associated behaviour is not well established...
- Strain-specific probiotic (Lactobacillus helveticus) inhibition of Campylobacter jejuni invasion of human intestinal epithelial cellsEytan Wine
Research Institute, Hospital for Sick Children, Toronto, ON, Canada
FEMS Microbiol Lett 300:146-52. 2009..The data support the concept of probiotic strain selectivity, which is dependent on the setting in which it is being evaluated and tested...
- Exposure to Ingested Airborne Pollutant Particulate Matter Increases Mucosal Exposure to Bacteria and Induces Early Onset of Inflammation in Neonatal IL-10-Deficient MiceSaad Y Salim
Departments of Medicine, and Pediatrics, University of Alberta, Edmonton, AB, Canada Department of Community Health Sciences, University of Calgary, Calgary, AB, Canada Environmental Health Directorate, Health Canada, Ottawa, ON, Canada Department of Lab Medicine and Pathology, University of Alberta, Edmonton, AB, Canada and Departments of Medicine, and Production Animal Health, University of Calgary, Calgary, AB, Canada
Inflamm Bowel Dis 20:1129-38. 2014..Our aim was to determine if exposure to airborne particulate matter (PM10) during the neonatal period would alter colitis in the interleukin (IL)-10 mouse model...
- Protein-tyrosine phosphatase sigma is associated with ulcerative colitisAleixo M Muise
Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, University of Toronto, 555 University Ave, Toronto, Ontario, Canada
Curr Biol 17:1212-8. 2007..We propose that polymorphisms in the human PTPRS gene lead to ulcerative colitis...
- Adherent-invasive Escherichia coli blocks interferon-γ-induced signal transducer and activator of transcription (STAT)-1 in human intestinal epithelial cellsJuan C Ossa
Research Institute, Hospital for Sick Children, University of Toronto, Toronto, ON, Canada
Cell Microbiol 15:446-57. 2013..We conclude that the suppression of epithelial cell STAT1 signal transduction by AIEC strains isolated from patients with Crohn disease represents a novel mechanism by which the pathogen evades host immune responses to the infection...
- Bacterial infections: new and emerging enteric pathogensPhilip M Sherman
Research Institute, Hospital for Sick Children, University of Toronto, Toronto, Canada
Curr Opin Gastroenterol 26:1-4. 2010....
- Campylobacter jejuni mediated disruption of polarized epithelial monolayers is cell-type specific, time dependent, and correlates with bacterial invasionEytan Wine
Department of Paediatrics, University of Toronto, Toronto, Ontario, M5G 1X8, Canada
Pediatr Res 64:599-604. 2008..jejuni disruption of monolayers is mediated by invasion, provide new insights into C. jejuni-host epithelial barrier interactions, and offer potential mechanisms of intestinal injury and chronic immune stimulation...
- Environmental particulate matter induces murine intestinal inflammatory responses and alters the gut microbiomeLisa Kish
Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
PLoS ONE 8:e62220. 2013..The aim of this study was to examine the effects of orally administered PM on the gut microbiome and immune function under normal and inflammatory conditions...
- Increased epithelial gaps in the small intestine are predictive of hospitalization and surgery in patients with inflammatory bowel diseaseJean Francois Turcotte
Division of Gastroenterology, Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada
Clin Transl Gastroenterol 3:e19. 2012..Cell-shedding events on CLE were found to be predictive of disease relapse. The aim of this study was to assess the prognostic value of epithelial gap densities for major clinical events (hospitalization or surgery) in follow-up...
- Epithelial gaps in a rodent model of inflammatory bowel disease: a quantitative validation studyJulia J Liu
Division of Gastroenterology, University of Alberta, Edmonton, Alberta, Canada
Clin Transl Gastroenterol 2:e3. 2011..The goal of this study was to quantitatively validate the findings of epithelial gap density observed with CLE against confocal microscopy (CM) and light microscopy...
- Biliary atresia with choledochal cyst: implications for classificationAleixo M Muise
Division of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, The Hospital for Sick Children, Toronto, Ontario, Canada
Clin Gastroenterol Hepatol 4:1411-4. 2006..To illustrate the limitations of the embryonic and perinatal classification system of biliary atresia (BA), we present a child with an antenatal diagnosis of choledochal cyst (CC) associated with BA and review the published literature...
- Probiotics prevent death caused by Citrobacter rodentium infection in neonatal miceMélanie G Gareau
Cell Biology Program, Research Institute, Hospital for Sick Children, University of Toronto, Ontario, Canada
J Infect Dis 201:81-91. 2010..Therefore, the aims of this study were to characterize Citrobacter rodentium infection in neonatal mice and determine the role played by specific probiotics in ameliorating disease severity...