Eytan Wine

Summary

Affiliation: University of Alberta
Country: Canada

Publications

  1. pmc A balanced IL-1β activity is required for host response to Citrobacter rodentium infection
    Misagh Alipour
    Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada Centre of Excellence for Gastrointestinal Inflammation and Immunity Research CEGIIR, University of Alberta, Edmonton, Alberta, Canada
    PLoS ONE 8:e80656. 2013
  2. ncbi request reprint Interleukin-6 is associated with steroid resistance and reflects disease activity in severe pediatric ulcerative colitis
    Eytan Wine
    Department of Pediatrics, University of Alberta, Edmonton, AB, Canada Electronic address
    J Crohns Colitis 7:916-22. 2013
  3. pmc Adherent-invasive Escherichia coli, strain LF82 disrupts apical junctional complexes in polarized epithelia
    Eytan Wine
    Research Institute, Hospital for Sick Children, Toronto, Ontario, Canada
    BMC Microbiol 9:180. 2009
  4. doi request reprint Epithelial cell extrusion leads to breaches in the intestinal epithelium
    Julia J Liu
    Gastroenterology Division, University of Alberta, Edmonton, Alberta, Canada
    Inflamm Bowel Dis 19:912-21. 2013
  5. pmc Osteopontin mediates Citrobacter rodentium-induced colonic epithelial cell hyperplasia and attaching-effacing lesions
    Eytan Wine
    Pediatric Gastroenterology, University of Alberta, Edmonton, Alberta, Canada
    Am J Pathol 177:1320-32. 2010
  6. doi request reprint Bacterial infection causes stress-induced memory dysfunction in mice
    Mélanie G Gareau
    Cell Biology Program, Research Institute, Hospital for Sick Children, Toronto, ON, Canada
    Gut 60:307-17. 2011
  7. doi request reprint Strain-specific probiotic (Lactobacillus helveticus) inhibition of Campylobacter jejuni invasion of human intestinal epithelial cells
    Eytan Wine
    Research Institute, Hospital for Sick Children, Toronto, ON, Canada
    FEMS Microbiol Lett 300:146-52. 2009
  8. ncbi request reprint Exposure to Ingested Airborne Pollutant Particulate Matter Increases Mucosal Exposure to Bacteria and Induces Early Onset of Inflammation in Neonatal IL-10-Deficient Mice
    Saad Y Salim
    Departments of Medicine, and Pediatrics, University of Alberta, Edmonton, AB, Canada Department of Community Health Sciences, University of Calgary, Calgary, AB, Canada Environmental Health Directorate, Health Canada, Ottawa, ON, Canada Department of Lab Medicine and Pathology, University of Alberta, Edmonton, AB, Canada and Departments of Medicine, and Production Animal Health, University of Calgary, Calgary, AB, Canada
    Inflamm Bowel Dis 20:1129-38. 2014
  9. ncbi request reprint Protein-tyrosine phosphatase sigma is associated with ulcerative colitis
    Aleixo M Muise
    Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, University of Toronto, 555 University Ave, Toronto, Ontario, Canada
    Curr Biol 17:1212-8. 2007
  10. doi request reprint Adherent-invasive Escherichia coli blocks interferon-γ-induced signal transducer and activator of transcription (STAT)-1 in human intestinal epithelial cells
    Juan C Ossa
    Research Institute, Hospital for Sick Children, University of Toronto, Toronto, ON, Canada
    Cell Microbiol 15:446-57. 2013

Collaborators

Detail Information

Publications17

  1. pmc A balanced IL-1β activity is required for host response to Citrobacter rodentium infection
    Misagh Alipour
    Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada Centre of Excellence for Gastrointestinal Inflammation and Immunity Research CEGIIR, University of Alberta, Edmonton, Alberta, Canada
    PLoS ONE 8:e80656. 2013
    ..Together, these findings highlight the importance of balanced cytokine responses as IL-1β improved bacterial clearance in Nlrp3(-/-) mice but increased tissue damage when given to WT mice. ..
  2. ncbi request reprint Interleukin-6 is associated with steroid resistance and reflects disease activity in severe pediatric ulcerative colitis
    Eytan Wine
    Department of Pediatrics, University of Alberta, Edmonton, AB, Canada Electronic address
    J Crohns Colitis 7:916-22. 2013
    ..Predicting response to IVCS to initiate early salvage therapy remains challenging. The aim of this study was to evaluate the role of serum inflammatory cytokines in ASC and determine their predictive utility with IVCS treatment failure...
  3. pmc Adherent-invasive Escherichia coli, strain LF82 disrupts apical junctional complexes in polarized epithelia
    Eytan Wine
    Research Institute, Hospital for Sick Children, Toronto, Ontario, Canada
    BMC Microbiol 9:180. 2009
    ..Therefore, the aim of this study was to delineate the effects of AIEC, strain LF82 (serotype O83:H1) on model polarized epithelial monolayers as a contributor to intestinal injury in IBD...
  4. doi request reprint Epithelial cell extrusion leads to breaches in the intestinal epithelium
    Julia J Liu
    Gastroenterology Division, University of Alberta, Edmonton, Alberta, Canada
    Inflamm Bowel Dis 19:912-21. 2013
    ..In this study, we sought to determine the mechanism underlying the IEC extrusion that alters the permeability of the gut epithelium...
  5. pmc Osteopontin mediates Citrobacter rodentium-induced colonic epithelial cell hyperplasia and attaching-effacing lesions
    Eytan Wine
    Pediatric Gastroenterology, University of Alberta, Edmonton, Alberta, Canada
    Am J Pathol 177:1320-32. 2010
    ..rodentium infection, indicating that OPN impacts disease pathogenesis through bacterial attachment and altered host immune responses...
  6. doi request reprint Bacterial infection causes stress-induced memory dysfunction in mice
    Mélanie G Gareau
    Cell Biology Program, Research Institute, Hospital for Sick Children, Toronto, ON, Canada
    Gut 60:307-17. 2011
    ..Whether intestinal events, such as enteric bacterial infections and bacterial colonisation, exert a reciprocal effect on stress-associated behaviour is not well established...
  7. doi request reprint Strain-specific probiotic (Lactobacillus helveticus) inhibition of Campylobacter jejuni invasion of human intestinal epithelial cells
    Eytan Wine
    Research Institute, Hospital for Sick Children, Toronto, ON, Canada
    FEMS Microbiol Lett 300:146-52. 2009
    ..The data support the concept of probiotic strain selectivity, which is dependent on the setting in which it is being evaluated and tested...
  8. ncbi request reprint Exposure to Ingested Airborne Pollutant Particulate Matter Increases Mucosal Exposure to Bacteria and Induces Early Onset of Inflammation in Neonatal IL-10-Deficient Mice
    Saad Y Salim
    Departments of Medicine, and Pediatrics, University of Alberta, Edmonton, AB, Canada Department of Community Health Sciences, University of Calgary, Calgary, AB, Canada Environmental Health Directorate, Health Canada, Ottawa, ON, Canada Department of Lab Medicine and Pathology, University of Alberta, Edmonton, AB, Canada and Departments of Medicine, and Production Animal Health, University of Calgary, Calgary, AB, Canada
    Inflamm Bowel Dis 20:1129-38. 2014
    ..Our aim was to determine if exposure to airborne particulate matter (PM10) during the neonatal period would alter colitis in the interleukin (IL)-10 mouse model...
  9. ncbi request reprint Protein-tyrosine phosphatase sigma is associated with ulcerative colitis
    Aleixo M Muise
    Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, University of Toronto, 555 University Ave, Toronto, Ontario, Canada
    Curr Biol 17:1212-8. 2007
    ..We propose that polymorphisms in the human PTPRS gene lead to ulcerative colitis...
  10. doi request reprint Adherent-invasive Escherichia coli blocks interferon-γ-induced signal transducer and activator of transcription (STAT)-1 in human intestinal epithelial cells
    Juan C Ossa
    Research Institute, Hospital for Sick Children, University of Toronto, Toronto, ON, Canada
    Cell Microbiol 15:446-57. 2013
    ..We conclude that the suppression of epithelial cell STAT1 signal transduction by AIEC strains isolated from patients with Crohn disease represents a novel mechanism by which the pathogen evades host immune responses to the infection...
  11. doi request reprint Bacterial infections: new and emerging enteric pathogens
    Philip M Sherman
    Research Institute, Hospital for Sick Children, University of Toronto, Toronto, Canada
    Curr Opin Gastroenterol 26:1-4. 2010
    ....
  12. ncbi request reprint Campylobacter jejuni mediated disruption of polarized epithelial monolayers is cell-type specific, time dependent, and correlates with bacterial invasion
    Eytan Wine
    Department of Paediatrics, University of Toronto, Toronto, Ontario, M5G 1X8, Canada
    Pediatr Res 64:599-604. 2008
    ..jejuni disruption of monolayers is mediated by invasion, provide new insights into C. jejuni-host epithelial barrier interactions, and offer potential mechanisms of intestinal injury and chronic immune stimulation...
  13. pmc Environmental particulate matter induces murine intestinal inflammatory responses and alters the gut microbiome
    Lisa Kish
    Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
    PLoS ONE 8:e62220. 2013
    ..The aim of this study was to examine the effects of orally administered PM on the gut microbiome and immune function under normal and inflammatory conditions...
  14. pmc Increased epithelial gaps in the small intestine are predictive of hospitalization and surgery in patients with inflammatory bowel disease
    Jean Francois Turcotte
    Division of Gastroenterology, Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada
    Clin Transl Gastroenterol 3:e19. 2012
    ..Cell-shedding events on CLE were found to be predictive of disease relapse. The aim of this study was to assess the prognostic value of epithelial gap densities for major clinical events (hospitalization or surgery) in follow-up...
  15. pmc Epithelial gaps in a rodent model of inflammatory bowel disease: a quantitative validation study
    Julia J Liu
    Division of Gastroenterology, University of Alberta, Edmonton, Alberta, Canada
    Clin Transl Gastroenterol 2:e3. 2011
    ..The goal of this study was to quantitatively validate the findings of epithelial gap density observed with CLE against confocal microscopy (CM) and light microscopy...
  16. ncbi request reprint Biliary atresia with choledochal cyst: implications for classification
    Aleixo M Muise
    Division of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, The Hospital for Sick Children, Toronto, Ontario, Canada
    Clin Gastroenterol Hepatol 4:1411-4. 2006
    ..To illustrate the limitations of the embryonic and perinatal classification system of biliary atresia (BA), we present a child with an antenatal diagnosis of choledochal cyst (CC) associated with BA and review the published literature...
  17. doi request reprint Probiotics prevent death caused by Citrobacter rodentium infection in neonatal mice
    Mélanie G Gareau
    Cell Biology Program, Research Institute, Hospital for Sick Children, University of Toronto, Ontario, Canada
    J Infect Dis 201:81-91. 2010
    ..Therefore, the aims of this study were to characterize Citrobacter rodentium infection in neonatal mice and determine the role played by specific probiotics in ameliorating disease severity...