Brian C Wilson

Summary

Affiliation: University of Toronto
Country: Canada

Publications

  1. ncbi request reprint Spectroscopy and fluorescence in esophageal diseases
    Ralph S Dacosta
    Department of Medical Biophysics, University of Toronto, Ontario Cancer Institute University Health Network, Toronto, Ont, Canada
    Best Pract Res Clin Gastroenterol 20:41-57. 2006
  2. ncbi request reprint Feasibility of interstitial Doppler optical coherence tomography for in vivo detection of microvascular changes during photodynamic therapy
    Heng Li
    Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada
    Lasers Surg Med 38:754-61. 2006
  3. doi request reprint The potential of biophotonic techniques in stem cell tracking and monitoring of tissue regeneration applied to cardiac stem cell therapy
    Brian C Wilson
    Division of Biophysics and Bioimaging, University Health Network, 610 University Ave, Toronto, ON M5G 2M9, Canada
    J Biophotonics 2:669-81. 2009
  4. doi request reprint The physics, biophysics and technology of photodynamic therapy
    Brian C Wilson
    Division of Biophysics and Bioimaging, Ontario Cancer Institute and Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada
    Phys Med Biol 53:R61-109. 2008
  5. ncbi request reprint Detection and treatment of dysplasia in Barrett's esophagus: a pivotal challenge in translating biophotonics from bench to bedside
    Brian C Wilson
    University of Toronto, Ontario Cancer Institute, Division of Biophysics and Bioimaging, Toronto, Ontario, Canada
    J Biomed Opt 12:051401. 2007
  6. ncbi request reprint Potential applications of photodynamic therapy in regenerative medicine
    Brian C Wilson
    Department of Medical Biophysics, Ontario Cancer Institute University Health Network, 610 University Avenue, Rm 7 417, Toronto, Ontario M5G 2M9, Canada
    J Craniofac Surg 14:278-83. 2003
  7. ncbi request reprint Photodynamic therapy for cancer: principles
    Brian C Wilson
    University of Toronto, Ontario Cancer Institute, Princess Margaret Hospital, 610 University Avenue, Toronto, Ontario M5G 2M9, Canada
    Can J Gastroenterol 16:393-6. 2002
  8. doi request reprint Treatment planning and dose analysis for interstitial photodynamic therapy of prostate cancer
    Sean R H Davidson
    Division of Biophysics and Bioimaging, Ontario Cancer Institute, University Health Network, 610 University Avenue, Toronto, Ontario M5G 2M9, Canada
    Phys Med Biol 54:2293-313. 2009
  9. doi request reprint Interstitial Doppler optical coherence tomography as a local tumor necrosis predictor in photodynamic therapy of prostatic carcinoma: an in vivo study
    Beau A Standish
    Department of Medical Biophysics and Radiation Oncology, University of Toronto, Ontario Cancer Institute University Health Network, Toronto, Canada
    Cancer Res 68:9987-95. 2008
  10. ncbi request reprint Interstitial Doppler optical coherence tomography monitors microvascular changes during photodynamic therapy in a Dunning prostate model under varying treatment conditions
    Beau A Standish
    Ontario Cancer Institute, University of Toronto, Department of Medical Biophysics, Toronto, Ontario M5G 2M9, Canada
    J Biomed Opt 12:034022. 2007

Collaborators

Detail Information

Publications102 found, 100 shown here

  1. ncbi request reprint Spectroscopy and fluorescence in esophageal diseases
    Ralph S Dacosta
    Department of Medical Biophysics, University of Toronto, Ontario Cancer Institute University Health Network, Toronto, Ont, Canada
    Best Pract Res Clin Gastroenterol 20:41-57. 2006
    ..g. surface), and staging (e.g. depth) of dysplasia, thereby allowing timely cure by endoscopic means (e.g. EMR and/or PDT), biological interventions (e.g. Cox-2 inhibitors) rather than esophajectomy...
  2. ncbi request reprint Feasibility of interstitial Doppler optical coherence tomography for in vivo detection of microvascular changes during photodynamic therapy
    Heng Li
    Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada
    Lasers Surg Med 38:754-61. 2006
    ..Using Dunning prostate cancer in a rat xenograft model, this study evaluated the feasibility of IS-DOCT monitoring of microvascular changes deep within a tumor caused by photodynamic therapy (PDT)...
  3. doi request reprint The potential of biophotonic techniques in stem cell tracking and monitoring of tissue regeneration applied to cardiac stem cell therapy
    Brian C Wilson
    Division of Biophysics and Bioimaging, University Health Network, 610 University Ave, Toronto, ON M5G 2M9, Canada
    J Biophotonics 2:669-81. 2009
    ..The scientific, technological, and logistics issues involved in moving some of these techniques from pre-clinical research mode ultimately into the clinic are also highlighted...
  4. doi request reprint The physics, biophysics and technology of photodynamic therapy
    Brian C Wilson
    Division of Biophysics and Bioimaging, Ontario Cancer Institute and Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada
    Phys Med Biol 53:R61-109. 2008
    ..The final section of the review introduces some new frontiers of research including low dose rate (metronomic) PDT, two-photon PDT, activatable PDT molecular beacons and nanoparticle-based PDT...
  5. ncbi request reprint Detection and treatment of dysplasia in Barrett's esophagus: a pivotal challenge in translating biophotonics from bench to bedside
    Brian C Wilson
    University of Toronto, Ontario Cancer Institute, Division of Biophysics and Bioimaging, Toronto, Ontario, Canada
    J Biomed Opt 12:051401. 2007
    ..The future directions for this field are considered, particularly from the perspective of relying on intrinsic (endogenous) optical signatures compared with the use of exogenous contrast agents...
  6. ncbi request reprint Potential applications of photodynamic therapy in regenerative medicine
    Brian C Wilson
    Department of Medical Biophysics, Ontario Cancer Institute University Health Network, 610 University Avenue, Rm 7 417, Toronto, Ontario M5G 2M9, Canada
    J Craniofac Surg 14:278-83. 2003
    ..This paper presents the basic principles of PDT and considers some of the possible applications in regenerative medicine...
  7. ncbi request reprint Photodynamic therapy for cancer: principles
    Brian C Wilson
    University of Toronto, Ontario Cancer Institute, Princess Margaret Hospital, 610 University Avenue, Toronto, Ontario M5G 2M9, Canada
    Can J Gastroenterol 16:393-6. 2002
    ..The fluorescence of many photosensitizers may be useful, either for (endoscopic) diagnosis or for PDT treatment guidance and monitoring...
  8. doi request reprint Treatment planning and dose analysis for interstitial photodynamic therapy of prostate cancer
    Sean R H Davidson
    Division of Biophysics and Bioimaging, Ontario Cancer Institute, University Health Network, 610 University Avenue, Toronto, Ontario M5G 2M9, Canada
    Phys Med Biol 54:2293-313. 2009
    ..The doses received by the urethra and the rectal wall were also investigated...
  9. doi request reprint Interstitial Doppler optical coherence tomography as a local tumor necrosis predictor in photodynamic therapy of prostatic carcinoma: an in vivo study
    Beau A Standish
    Department of Medical Biophysics and Radiation Oncology, University of Toronto, Ontario Cancer Institute University Health Network, Toronto, Canada
    Cancer Res 68:9987-95. 2008
    ....
  10. ncbi request reprint Interstitial Doppler optical coherence tomography monitors microvascular changes during photodynamic therapy in a Dunning prostate model under varying treatment conditions
    Beau A Standish
    Ontario Cancer Institute, University of Toronto, Department of Medical Biophysics, Toronto, Ontario M5G 2M9, Canada
    J Biomed Opt 12:034022. 2007
    ..These dependencies may play an important role in PDT treatment planning, feedback control for treatment optimization, and post-treatment assessment...
  11. ncbi request reprint Doppler optical coherence tomography monitoring of microvascular tissue response during photodynamic therapy in an animal model of Barrett's esophagus
    Beau A Standish
    Department of Medical Biophysics, University of Toronto, Ontario Cancer Institute, Toronto, Ontario, Canada
    Gastrointest Endosc 66:326-33. 2007
    ....
  12. doi request reprint Defining the therapeutic window of vertebral photodynamic therapy in a murine pre-clinical model of breast cancer metastasis using the photosensitizer BPD-MA (Verteporfin)
    Margarete K Akens
    Division of Orthopaedic Surgery, Sunnybrook Health Science Centre, Room E2 44, 2075 Bayview Ave, Toronto, ON M4N 3M5, Canada
    Breast Cancer Res Treat 119:325-33. 2010
    ..Overall, PDT represents an exciting potential new minimally-invasive local, safe and effective therapy in the management of patients with spinal metastases...
  13. pmc Oxygen-independent degradation of HIF-alpha via bioengineered VHL tumour suppressor complex
    Roxana I Sufan
    Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada
    EMBO Mol Med 1:66-78. 2009
    ..These findings introduce the concept and feasibility of 'bio-tailored' enzymes in the treatment of HIF-overexpressing tumours...
  14. doi request reprint A tumor mRNA-triggered photodynamic molecular beacon based on oligonucleotide hairpin control of singlet oxygen production
    Juan Chen
    Division of Biophysics and Bioimaging, Ontario Cancer Institute, Toronto, Ontario M5G 1L7, Canada
    Photochem Photobiol Sci 7:775-81. 2008
    ..When incubated with c-raf-1 expressing MDA-MB-231 cancer cells, the PMB displayed efficient cellular uptake and subsequently effective PDT activation in targeted cells...
  15. ncbi request reprint Fluorescence image-guided brain tumour resection with adjuvant metronomic photodynamic therapy: pre-clinical model and technology development
    Arjen Bogaards
    Division of Biophysics and Bioimaging, Ontario Cancer Institute, University Health Network and University of Toronto, Toronto, Ontario, M5G 2M9, Canada
    Photochem Photobiol Sci 4:438-42. 2005
    ..These results demonstrate that the combined treatment is technically feasible and this model is a candidate to evaluate it. Further optimization of mPDT treatment parameters (drug/light dose rates) is required to improve survival...
  16. doi request reprint Beyond bisphosphonates: photodynamic therapy structurally augments metastatically involved vertebrae and destroys tumor tissue
    Emily Won
    Orthopaedic Biomechanics Laboratory, Division of Orthopaedic Surgery, Sunnybrook Health Sciences Centre, Room UB 19, 2075 Bayview Ave, Toronto, ON M4N 3M5, Canada
    Breast Cancer Res Treat 124:111-9. 2010
    ..Overall, the ability of PDT to both ablate malignant tissue and improve the structural integrity of vertebral bone motivates its consideration as a local minimally invasive treatment for spinal metastasis secondary to breast cancer...
  17. ncbi request reprint Speckle variance detection of microvasculature using swept-source optical coherence tomography
    Adrian Mariampillai
    Department of Medical Biophysics, University of Toronto, Toronto, M5G 2M9, Canada
    Opt Lett 33:1530-2. 2008
    ....
  18. ncbi request reprint Endoscopic Doppler optical coherence tomography in the human GI tract: initial experience
    Victor X D Yang
    Faculty of Medicine, Department of Medical Biophysics, University of Toronto, Canada
    Gastrointest Endosc 61:879-90. 2005
    ..The aim of this feasibility study was to assess the clinical feasibility of an endoscopic Doppler OCT (EDOCT) system in the human GI tract...
  19. doi request reprint The benefits of photodynamic therapy on vertebral bone are maintained and enhanced by combination treatment with bisphosphonates and radiation therapy
    Victor C K Lo
    Orthopaedic Biomechanics Laboratory, Sunnybrook Research Institute, UB 55, 2075 Bayview Avenue, Toronto, Ontario, M4N 3M5, Canada
    J Orthop Res 31:1398-405. 2013
    ..Overall, multimodality treatment demonstrated a sustained positive effect on vertebral structural integrity, motivating PDT as a minimally-invasive adjuvant treatment for spinal metastases...
  20. doi request reprint Drug and light dose responses to focal photodynamic therapy of single blood vessels in vivo
    Mamta Khurana
    University of Toronto, Division of Biophysics and Bioimaging, Department of Medical Biophysics, Ontario Cancer Institute, Toronto, Ontario M5G2M9, Canada
    J Biomed Opt 14:064006. 2009
    ..Demonstration of reciprocity over a wide range of DLP is important for further development of focal PDT treatments, such as the targeting of feeder vessels in 2-gamma PDT of AMD...
  21. doi request reprint The influence of hypoxia on bioluminescence in luciferase-transfected gliosarcoma tumor cells in vitro
    Eduardo H Moriyama
    Division of Biophysics and Bioimaging Ontario Cancer Institute University of Toronto, 610 University Avenue 7 417, Toronto, Ontario M5G 2M9, Canada
    Photochem Photobiol Sci 7:675-80. 2008
    ....
  22. doi request reprint Polarization birefringence measurements for characterizing the myocardium, including healthy, infarcted, and stem-cell-regenerated tissues
    Michael F G Wood
    Ontario Cancer Institute, Division of Biophysics and Bioimaging, Toronto, Ontario, Canada
    J Biomed Opt 15:047009. 2010
    ....
  23. doi request reprint FRET quenching of photosensitizer singlet oxygen generation
    Jonathan F Lovell
    Institute of Biomaterials and Biomedical Engineering, Department of Medical Biophysics, University of Toronto, Canada
    J Phys Chem B 113:3203-11. 2009
    ..The presented findings show that FRET-based quenchers can potently decrease singlet oxygen production and therefore be used to facilitate the rational design of activatable photosensitizers...
  24. doi request reprint Beyond radiation therapy: photodynamic therapy maintains structural integrity of irradiated healthy and metastatically involved vertebrae in a pre-clinical in vivo model
    Victor C K Lo
    Orthopaedic Biomechanics Laboratory, Sunnybrook Research Institute, UB 55, 2075 Bayview Avenue, Toronto, ON M4N 3M5, Canada
    Breast Cancer Res Treat 135:391-401. 2012
    ....
  25. doi request reprint Proof-of-principle demonstration of a Mueller matrix decomposition method for polarized light tissue characterization in vivo
    Michael F G Wood
    Ontario Cancer Institute, Division of Biophysics and Bioimaging, University Health Network, 610 University Avenue, Toronto, Ontario M5G 2M9 Canada
    J Biomed Opt 14:014029. 2009
    ..This study represents the first in vivo demonstration of a Mueller matrix decomposition method for polarimetric tissue characterization...
  26. doi request reprint Vascular-targeted photodynamic therapy (padoporfin, WST09) for recurrent prostate cancer after failure of external beam radiotherapy: a study of escalating light doses
    John Trachtenberg
    Surgical Oncology, Ontario Cancer Institute Princess Margaret Hospital, Toronto, Canada
    BJU Int 102:556-62. 2008
    ....
  27. ncbi request reprint Using the singlet oxygen scavenging property of carotenoid in photodynamic molecular beacons to minimize photodamage to non-targeted cells
    Juan Chen
    Division of Biophysics and Bioimaging, Ontario Cancer Institute, Toronto, ON M5G 1L7, Canada
    Photochem Photobiol Sci 6:1311-7. 2007
    ..Moreover, the in vitro PDT response showed that CAR completely shuts off the photodynamic effect in non-targeted HepG(2) cells, while PS without CAR (control) remains highly potent even at a much lower (30-fold) dose...
  28. doi request reprint Prostate tissue composition and MR measurements: investigating the relationships between ADC, T2, K(trans), v(e), and corresponding histologic features
    Deanna L Langer
    Department of Medical Imaging, Princess Margaret Hospital, University Health Network and Mount Sinai Hospital, 610 University Ave, Room 3 958, Toronto, ON, Canada M5G 2M9
    Radiology 255:485-94. 2010
    ..To investigate relationships between magnetic resonance (MR) imaging measurements and the underlying composition of normal and malignant prostate tissue...
  29. doi request reprint Assessment of photobleaching during endoscopic autofluorescence imaging of the lower GI tract
    Alexandre Douplik
    Ontario Cancer Institute, Princess Margaret Hospital, University Health Network, Toronto, ON, Canada
    Lasers Surg Med 42:224-31. 2010
    ....
  30. doi request reprint Biodistribution and pharmacokinetic studies of a porphyrin dimer photosensitizer (Oxdime) by fluorescence imaging and spectroscopy in mice bearing xenograft tumors
    Mamta Khurana
    Department of Medical Biophysics, University of Toronto Ontario Cancer Institute, Toronto, ON
    Photochem Photobiol 88:1531-8. 2012
    ..Significant quantities accumulated in the tumor, indicating that this PDT sensitizer may be promising for cancer treatment...
  31. pmc Hypoxia promotes ligand-independent EGF receptor signaling via hypoxia-inducible factor-mediated upregulation of caveolin-1
    Yi Wang
    Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada M5S 1A8
    Proc Natl Acad Sci U S A 109:4892-7. 2012
    ....
  32. ncbi request reprint Quantitative in vitro demonstration of two-photon photodynamic therapy using photofrin and visudyne
    Mamta Khurana
    Department of Medical Biophysics, Ontario Cancer Institute, University of Toronto, Toronto, ON, Canada
    Photochem Photobiol 83:1441-8. 2007
    ....
  33. ncbi request reprint Techniques for delivery and monitoring of TOOKAD (WST09)-mediated photodynamic therapy of the prostate: clinical experience and practicalities
    Robert A Weersink
    Laboratory for Applied Biophotonics, University Health Network, University Avenue, Toronto, Canada
    J Photochem Photobiol B 79:211-22. 2005
    ..Further development of these delivery and monitoring techniques will permit full on-line monitoring of the treatment that will enable real-time, patient-specific and optimized delivery of PDT...
  34. doi request reprint Imaging of specific activation of photodynamic molecular beacons in breast cancer vertebral metastases
    Tracy W Liu
    Department of Medical Biophysics, University of Toronto, Canada
    Bioconjug Chem 22:1021-30. 2011
    ..Here, we validate that the metastasis-selective mechanism of PP(MMP)Bs can specifically image breast cancer vertebral metastases, thereby differentiating tumor and healthy tissue...
  35. doi request reprint Effects of photodynamic therapy on the structural integrity of vertebral bone
    Emily Won
    Orthopaedic Biomechanics Laboratory, Division of Orthopaedics, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
    Spine (Phila Pa 1976) 35:272-7. 2010
    ..This study investigates the effects of photodynamic therapy (PDT) on the structural integrity of vertebral bone in healthy rats...
  36. ncbi request reprint Increased brain tumor resection using fluorescence image guidance in a preclinical model
    Arjen Bogaards
    Department of Medical Biophysics, Ontario Cancer Institute University Health Network and University of Toronto, Toronto, Ontario, Canada M5G 2M9
    Lasers Surg Med 35:181-90. 2004
    ..We compared resection completeness and residual tumor, determined by histopathology, after white light resection (WLR) using an operating microscope versus additional fluorescence guided resection (FGR)...
  37. doi request reprint Estimation of minimum doses for optimized quantum dot contrast-enhanced vascular imaging in vivo
    Mathieu Roy
    Department of Medical Biophysics, University of Toronto, 610 University Ave, Toronto, Ontario, Canada
    Small 8:1780-92. 2012
    ..It also proposes and validates a theoretical framework for QD dose estimation and quantifies the effects of blood absorption, QD emission wavelength, and vessel diameter relative to the threshold dose...
  38. doi request reprint Effect of tissue optics on wavelength optimization for quantum dot-based surface and subsurface fluorescence imaging
    Mathieu Roy
    University of Toronto, Ontario Cancer Institute, Department of Medical Biophysics, 610 University Avenue, Toronto, Ontario, M5G 2M9 Canada
    J Biomed Opt 17:026002. 2012
    ..This work contributes to the development of robust and quantitative dosimetry for QD-based fluorescence imaging near to the tissue surface...
  39. pmc Insights into photodynamic therapy dosimetry: simultaneous singlet oxygen luminescence and photosensitizer photobleaching measurements
    Mark T Jarvi
    Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada
    Biophys J 102:661-71. 2012
    ..These studies improve our understanding of PDT processes, demonstrate that SOL is a valuable gold-standard dose metric, and show that when used judiciously, photobleaching can serve as a surrogate for (1)O(2) dose...
  40. doi request reprint Optimized speckle variance OCT imaging of microvasculature
    Adrian Mariampillai
    Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada
    Opt Lett 35:1257-9. 2010
    ..We also show svOCT imaging of the nonstabilized finger (high bulk motion), using optimized imaging parameters, demonstrating better vessel detection than Doppler OCT...
  41. ncbi request reprint Photodynamic therapy of vertebral metastases: evaluating tumor-to-neural tissue uptake of BPD-MA and ALA-PpIX in a murine model of metastatic human breast carcinoma
    Margarete K Akens
    Division of Orthopaedic Surgery, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
    Photochem Photobiol 83:1034-9. 2007
    ..The highest ratio for BPD-MA concentration was found 15 min after injection, which can be recommended for therapy in this model...
  42. doi request reprint "Zipper" molecular beacons: a generalized strategy to optimize the performance of activatable protease probes
    Juan Chen
    Department of Medical Biophysics, Ontario Cancer Institute, University of Toronto, Toronto, Ontario, Canada
    Bioconjug Chem 20:1836-42. 2009
    ..This ZMB concept is a generalizable approach to improve the functionality of a wide range of diagnostic/therapeutic probes through a simple switching of substrate sequences...
  43. doi request reprint Fluorescence and spectral imaging
    Ralph S Dacosta
    Department of Medical Biophysics, University of Toronto, Ontario Cancer Institute, 610 University Avenue, Toronto, Ontario, M5G 2M9, Canada
    ScientificWorldJournal 7:2046-71. 2007
    ..e., quantum dots). This is an area of great promise, but still in its infancy, and preclinical studies are currently under way...
  44. pmc Quantification of in vivo fluorescence decoupled from the effects of tissue optical properties using fiber-optic spectroscopy measurements
    Anthony Kim
    University of Toronto, Department of Medical Biophysics, Toronto, Ontario, Canada
    J Biomed Opt 15:067006. 2010
    ..This technique is validated in phantoms and ex vivo mouse tissues, and tested in vivo in a rabbit brain tumor model using ALA-PpIX fluorescence contrast...
  45. ncbi request reprint Pre-clinical in vitro and in vivo studies to examine the potential use of photodynamic therapy in the treatment of osteomyelitis
    Stuart K Bisland
    Ontario Cancer Institute, University Health Network, University of Toronto, 610 University Ave, Toronto, Canada
    Photochem Photobiol Sci 5:31-8. 2006
    ..In vivo, ALA-mediated PDT inhibited biofilm implants in bone. These results confirm that MB or ALA-mediated PDT have potential to treat S. aureus cultures grown in vitro or in vivo using an animal model of osteomyelitis...
  46. ncbi request reprint Bioluminescence imaging of the response of rat gliosarcoma to ALA-PpIX-mediated photodynamic therapy
    Eduardo H Moriyama
    Department of Medical Biophysics, Ontario Cancer Institute, University of Toronto, Toronto M5G 2M9, Ontario, Canada
    Photochem Photobiol 80:242-9. 2004
    ..These results suggest that BLI can be used to provide spatiotemporal information of intracranial brain tumor responses after PDT and may serve as a valuable response-endpoint measure...
  47. doi request reprint Facile synthesis of advanced photodynamic molecular beacon architectures
    Jonathan F Lovell
    Department of Medical Biophysics, Ontario Cancer Institute, University of Toronto, Ontario
    Bioconjug Chem 21:1023-5. 2010
    ..Linear superquenchers exhibited highly efficient quenching. This fully automated synthesis method simplifies not only the synthesis and purification of PMBs, but also the creation of new activatable photosensitizer designs...
  48. pmc Biologically-targeted detection of primary and micro-metastatic ovarian cancer
    Tracy W Liu
    Department of Medical Biophysics, Princess Margarete Cancer Center, University of Toronto, Toronto, Canada
    Theranostics 3:420-7. 2013
    ....
  49. pmc Inherently multimodal nanoparticle-driven tracking and real-time delineation of orthotopic prostate tumors and micrometastases
    Tracy W Liu
    Ontario Cancer Institute, Campbell Family Institute for Cancer Research and Techna Institute, UHN, 610 University Avenue, Toronto, ON Canada M5G 2M9
    ACS Nano 7:4221-32. 2013
    ..The unique and multifaceted properties of porphysomes offers a promising all-in-one prostate cancer imaging agent for tumor detection and treatment response/recurrence monitoring using both radionuclide- and photonic-based strategies...
  50. pmc Hierarchical model of fibrillar collagen organization for interpreting the second-order susceptibility tensors in biological tissue
    Adam E Tuer
    Department of Physics, University of Toronto, Toronto, Ontario, Canada
    Biophys J 103:2093-105. 2012
    ..From the P-SHG parameters of vertebrae tissue, a three-dimensional reconstruction of lamellae of intervertebral disk is presented...
  51. doi request reprint Intrinsically copper-64-labeled organic nanoparticles as radiotracers
    Tracy W Liu
    Ontario Cancer Institute, Campbell Family Institute for Cancer Research, UHN, Canada
    Angew Chem Int Ed Engl 51:13128-31. 2012
    ..These (64) Cu-porphysomes can be accurately and noninvasively tracked in vivo...
  52. doi request reprint Porphyrin shell microbubbles with intrinsic ultrasound and photoacoustic properties
    Elizabeth Huynh
    Ontario Cancer Institute and Techna Institute, University Health Network, Toronto, Ontario, Canada M5G 1L7
    J Am Chem Soc 134:16464-7. 2012
    ..The distinctive properties of porshe MBs make them potentially advantageous for a broad range of biomedical imaging and therapeutic applications...
  53. ncbi request reprint Photodynamic therapy of brain tumors--a work in progress
    Paul J Muller
    Division of Neurosurgery, St Michael s Hospital, University of Toronto, Ontario, Canada
    Lasers Surg Med 38:384-9. 2006
    ..PDT has been used in the treatment of malignant brain tumors. This communication updates our series of unselected malignant gliomas treated with Photofrin-PDT...
  54. ncbi request reprint Interstitial Doppler optical coherence tomography
    Victor X D Yang
    University Health Network, Toronto, Ontario, Canada
    Opt Lett 30:1791-3. 2005
    ..To our knowledge, this is the first demonstration of Doppler OCT through a needle probe in interstitial applications to visualize deeply situated microcirculation...
  55. pmc Oncolytic targeting of renal cell carcinoma via encephalomyocarditis virus
    Frederik C Roos
    Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada
    EMBO Mol Med 2:275-88. 2010
    ..These findings provide compelling pre-clinical evidence for the usage of EMCV in the treatment of CCRCC and potentially other tumours with elevated HIF/NF-kappaB-survival signature...
  56. doi request reprint The influence of oxygen depletion and photosensitizer triplet-state dynamics during photodynamic therapy on accurate singlet oxygen luminescence monitoring and analysis of treatment dose response
    Mark T Jarvi
    Department of Medical Biophysics, University of Toronto Ontario Cancer Institute, Toronto, ON, Canada
    Photochem Photobiol 87:223-34. 2011
    ..In vitro studies with both mTHPC and aminolevulinic acid-photosensitizer protoporphyrin IX demonstrate that rigorous analysis of SOL signal kinetics is then crucial in order to use SOL as an accurate and quantitative PDT dose metric...
  57. ncbi request reprint Doppler optical coherence tomography with a micro-electro-mechanical membrane mirror for high-speed dynamic focus tracking
    Victor X D Yang
    Ontario Cancer Institute, University Health Network, Toronto, Ontario, Canada
    Opt Lett 31:1262-4. 2006
    ..The mirror's small size (1.4 mm x 1 mm) will allow integration with endoscopic MEMS-DOCT for in vivo applications...
  58. ncbi request reprint Imaging the modulation of adenoviral kinetics and biodistribution for cancer gene therapy
    Joseph D Mocanu
    Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada
    Mol Ther 15:921-9. 2007
    ..This study reports the favorable modulation by STI571 of the biodistribution of adenoviral vectors, providing a potential approach to improving therapeutic outcome...
  59. ncbi request reprint Imaging of photodynamically generated singlet oxygen luminescence in vivo
    Mark J Niedre
    Department of Medical Biophysics, Ontario Cancer Institute and University of Toronto, Toronto, Ontario, Canada
    Photochem Photobiol 81:941-3. 2005
    ..We verify the strong oxygen-dependence of the signal and show that the images are near the practical resolution limit...
  60. doi request reprint Prostate cancer detection with multi-parametric MRI: logistic regression analysis of quantitative T2, diffusion-weighted imaging, and dynamic contrast-enhanced MRI
    Deanna L Langer
    Department of Medical Imaging, Princess Margaret Hospital, University Health Network and Mount Sinai Hospital, Toronto, Ontario, Canada
    J Magn Reson Imaging 30:327-34. 2009
    ..To develop a multi-parametric model suitable for prospectively identifying prostate cancer in peripheral zone (PZ) using magnetic resonance imaging (MRI)...
  61. doi request reprint Homogenized tissue phantoms for quantitative evaluation of subsurface fluorescence contrast
    Mathieu Roy
    University Health Network, University of Toronto and Ontario Cancer Institute, Department of Medical Biophysics, 610 University Avenue, Toronto, ON, M5G 2M9 Canada
    J Biomed Opt 16:016013. 2011
    ..The tissue homogenate method should be of value for quantitative optimization studies relevant to, for example, endoscopic imaging...
  62. pmc Topographic mapping of subsurface fluorescent structures in tissue using multiwavelength excitation
    Anthony Kim
    University of Toronto, Department of Medical Biophysics, Toronto, Ontario, Canada
    J Biomed Opt 15:066026. 2010
    ..This method has potential for fluorescence image-guided tumor surgery, as well as other biomedical and nonbiological applications in subsurface sensing...
  63. ncbi request reprint Singlet oxygen luminescence dosimetry (SOLD) for photodynamic therapy: current status, challenges and future prospects
    Mark T Jarvi
    Department of Medical Biophysics, Ontario Cancer Institute and University of Toronto, Toronto, Ontario, Canada
    Photochem Photobiol 82:1198-210. 2006
    ....
  64. ncbi request reprint Prostate gland: MR imaging appearance after vascular targeted photodynamic therapy with palladium-bacteriopheophorbide
    Masoom A Haider
    Joint Department of Medical Imaging, Princess Margaret Hospital, University Health Network and Mount Sinai Hospital, University of Toronto, 610 University Ave, Toronto, ON, Canada
    Radiology 244:196-204. 2007
    ....
  65. pmc Photodynamic molecular beacon as an activatable photosensitizer based on protease-controlled singlet oxygen quenching and activation
    Gang Zheng
    Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada M5G 1L7
    Proc Natl Acad Sci U S A 104:8989-94. 2007
    ..Rather, it will depend on how selective a biomarker is to cancer cells, and how selective the interaction of PMB is to this biomarker...
  66. doi request reprint Uroporphyrinogen decarboxylase is a radiosensitizing target for head and neck cancer
    Emma Ito
    Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada M5G 2M9
    Sci Transl Med 3:67ra7. 2011
    ..Thus, our study has revealed UROD as a potent tumor-selective sensitizer for both radiation and chemotherapy, with potential relevance to many human malignancies...
  67. ncbi request reprint Diblock copolymer micelles deliver hydrophobic protoporphyrin IX for photodynamic therapy
    Buhong Li
    Department of Medical Biophysics, University of Toronto, Ontario Cancer Institute University Health Network, Toronto, ON, Canada
    Photochem Photobiol 83:1505-12. 2007
    ..The micelles alone had no evident phototoxicity or dark toxicity. These findings suggest that MePEG(5000)-b-PCL(4100) diblock copolymer micelles have great potential as a drug delivery system for hydrophobic photodynamic sensitizers...
  68. ncbi request reprint In vitro tests of the validity of singlet oxygen luminescence measurements as a dose metric in photodynamic therapy
    Mark J Niedre
    Department of Medical Biophysics, Ontario Cancer Institute University Health Network, 610 University Avenue, Toronto, Ontario M5G 2M9, Canada
    Cancer Res 63:7986-94. 2003
    ..This study supports the validity and potential utility of (1)O(2) luminescence measurement as a dosimetric tool for PDT, as well as confirming the likely role of (1)O(2) in porphyrin-based PDT...
  69. doi request reprint Continuous docetaxel chemotherapy improves therapeutic efficacy in murine models of ovarian cancer
    Raquel De Souza
    Department of Pharmaceutical Sciences, University of Toronto, Ontario, Canada
    Mol Cancer Ther 9:1820-30. 2010
    ..Overall, our results show greater therapeutic advantages of continuous over intermittent chemotherapy in the treatment of ovarian cancer...
  70. ncbi request reprint Critical role for Fas-associated death domain-like interleukin-1-converting enzyme-like inhibitory protein in anoikis resistance and distant tumor formation
    Imtiaz A Mawji
    Ontario Cancer Institute, Princess Margaret Hospital, 610 University Ave, Toronto, ON, Canada, M5G 2M9
    J Natl Cancer Inst 99:811-22. 2007
    ..We hypothesized that c-Fas-associated death domain-like interleukin-1-converting enzyme-like inhibitory protein (FLIP), an endogenous inhibitor of death receptor signaling, may suppress anoikis...
  71. ncbi request reprint Simultaneous two-photon excitation of photofrin in relation to photodynamic therapy
    Aliaksandr Karotki
    Division of Biophysics and Bioimaging, Ontario Cancer Institute, University of Toronto, Toronto, Ontario, Canada
    Photochem Photobiol 82:443-52. 2006
    ....
  72. doi request reprint Feasibility study of autofluorescence mammary ductoscopy
    Alexandre Douplik
    Ontario Cancer Institute, University Health Network, 7 417 610 University Avenue, Toronto, M5G 2M9 Canada
    J Biomed Opt 14:044036. 2009
    ..Point fluoroscopy is also performed. Although the optical "geometry" for this is different, the findings are consistent with the imaging observations...
  73. ncbi request reprint Micromachined array tip for multifocus fiber-based optical coherence tomography
    Victor X D Yang
    Department of Medical Biophysics, University of Toronto, Toronto, Ontario M5G 2M9, Canada
    Opt Lett 29:1754-6. 2004
    ....
  74. ncbi request reprint A multispectral fluorescence imaging system: design and initial clinical tests in intra-operative Photofrin-photodynamic therapy of brain tumors
    Victor X D Yang
    Department of Medical Biophysics, University of Toronto, Canada
    Lasers Surg Med 32:224-32. 2003
    ..Intra-operative identification of tumor by fluorescence may improve surgical resection or photodynamic therapy (PDT). A novel instrument was designed, constructed, and tested for this purpose...
  75. pmc Androgen induces adaptation to oxidative stress in prostate cancer: implications for treatment with radiation therapy
    Jehonathan H Pinthus
    The Prostate Cancer Center, University Health Network, Toronto, Ontario, Canada
    Neoplasia 9:68-80. 2007
    ..Thus, testosterone induces a preset cellular adaptation to radiation through the generation of elevated bROS, which is modified by AD. These findings provide a rational for combined hormonal and radiation therapy for localized PC...
  76. ncbi request reprint Optical techniques for the endoscopic detection of dysplastic colonic lesions
    Ralph S Dacosta
    Department of Medical Biophysics, University of Toronto, Ontario Cancer Institute University Health Network, Toronto, Ontario, Canada
    Curr Opin Gastroenterol 21:70-9. 2005
    ..This review presents the current status of emerging optical techniques that rely on the complex interaction of light with tissue, and their possible roles in detection, mapping, staging, and therapy of dysplasia...
  77. ncbi request reprint Metronomic photodynamic therapy as a new paradigm for photodynamic therapy: rationale and preclinical evaluation of technical feasibility for treating malignant brain tumors
    Stuart K Bisland
    Ontario Cancer Institute, University Health Network, 610 University Avenue, Toronto, Ontario, Canada M5G 2M9
    Photochem Photobiol 80:22-30. 2004
    ..The combined delivery of both drug and light during an extended period, without compromising survival of the animals, is demonstrated. Preliminary evidence of selective apoptosis of tumor under these conditions is presented...
  78. ncbi request reprint A new technique for physiodesis using photodynamic therapy
    Stuart K Bisland
    Princess Margaret Hospital, Department of Medical Physics, Uniersity Health Network, Toronto, Ontario, Canada
    Clin Orthop Relat Res 461:153-61. 2007
    ..At 4 weeks posttreatment, limbs were shortened by an average of 9.5% +/- 4.4% without complication, confirming the potential application of photodynamic therapy for physiodesis...
  79. ncbi request reprint Radiance-based monitoring of the extent of tissue coagulation during laser interstitial thermal therapy
    Lee C Chin
    Department of Medical Biophysics, University of Toronto, Ontario Cancer Institute, Toronto M5G 2M9, Canada
    Opt Lett 29:959-61. 2004
    ..We performed experiments with albumen phantoms to demonstrate the practicality of the radiance method for monitoring interstitial laser thermal therapy...
  80. ncbi request reprint High throughput quantification of protein expression of cancer antigens in tissue microarray using quantum dot nanocrystals
    Arezou A Ghazani
    Division of Applied Molecular Oncology, Ontario Cancer Institute, Toronto, Ontario M5G 2M9, Canada
    Nano Lett 6:2881-6. 2006
    ..The integration of this method for tissue analysis in the clinic bears potential impact for improving the diagnosis and treatment of cancer...
  81. ncbi request reprint Assessment of cutaneous photosensitivity of TOOKAD (WST09) in preclinical animal models and in patients
    Robert A Weersink
    Laboratory for Applied Biophotonics, University Health Network, Toronto, Canada
    Photochem Photobiol 81:106-13. 2005
    ..Using the full spectrum of solar-simulated light, the presence of TOOKAD did not measurably enhance the UV(+)-induced erythema in the rats, pigs or patients...
  82. ncbi request reprint In vivo Doppler optical coherence tomography of mucocutaneous telangiectases in hereditary hemorrhagic telangiectasia
    Shou Jiang Tang
    Center for Therapeutic Endoscopy and Endoscopic Oncology, Division of Respiratory Medicine, Department of Medicine, St Michael s Hospital, Ontario, Canada
    Gastrointest Endosc 58:591-8. 2003
    ..It was hypothesized that visibly normal areas may have occult telangiectases and that mucocutaneous telangiectases that have bled may have a higher rate of blood flow than mucocutaneous telangiectases with no history of bleeding...
  83. ncbi request reprint Direct near-infrared luminescence detection of singlet oxygen generated by photodynamic therapy in cells in vitro and tissues in vivo
    Mark Niedre
    Department of Medical Biophysics, Ontario Cancer Institute University of Toronto, Canada
    Photochem Photobiol 75:382-91. 2002
    ..We believe that these are the first direct observations of PDT-generated intracellular and in vivo 102. The detector technology provides a new tool for PDT research and possibly clinical use...
  84. doi request reprint A fiberoptic reflectance probe with multiple source-collector separations to increase the dynamic range of derived tissue optical absorption and scattering coefficients
    Anthony Kim
    Department of Medical Biophysics, University of Toronto and Ontario Cancer Institute Campbell Family Institute for Cancer Research, University Health Network, 610 University Avenue, Toronto, Ontario, M5G 2M9, Canada
    Opt Express 18:5580-94. 2010
    ..The dynamic range and accuracy of this method were evaluated using Monte Carlo simulations, phantom experiments and tissues in vivo...
  85. doi request reprint Mueller matrix decomposition for polarized light assessment of biological tissues
    Nirmalya Ghosh
    Ontario Cancer Institute, Division of Biophysics and Bioimaging, University Health Network, Toronto, Ontario, Canada
    J Biophotonics 2:145-56. 2009
    ..Results demonstrate potential for both applications...
  86. ncbi request reprint Complete blood vessel occlusion in the chick chorioallantoic membrane using two-photon excitation photodynamic therapy: implications for treatment of wet age-related macular degeneration
    Kimberley S Samkoe
    University of Calgary, Department of Chemistry, 2500 University Drive, Northwest, Calgary, Alberta T2N 1N4, Canada
    J Biomed Opt 12:034025. 2007
    ..Further investigation will help determine the utility of TPE-PDT for treating wet AMD, perhaps through targeting feeder vessels...
  87. ncbi request reprint Preclinical studies in normal canine prostate of a novel palladium-bacteriopheophorbide (WST09) photosensitizer for photodynamic therapy of prostate cancers
    Qun Chen
    HealthONE Alliance, Denver, CO 80218, USA
    Photochem Photobiol 76:438-45. 2002
    ..Hence, Tookad-PDT appears to be a promising candidate for prostate ablation in patients with recurrent, or possibly even primary, prostate cancer...
  88. pmc Effects of Pd-bacteriopheophorbide (TOOKAD)-mediated photodynamic therapy on canine prostate pretreated with ionizing radiation
    Zheng Huang
    HealthONE Alliance, Denver, Colorado 80203, USA
    Radiat Res 161:723-31. 2004
    ....
  89. ncbi request reprint Multimodality imaging for vertebral metastases in a rat osteolytic model
    Shane Burch
    Department of Orthopaedic Surgery, University of California San Francisco, San Francisco, CA, USA
    Clin Orthop Relat Res 454:230-6. 2007
    ..Early identification of metastasis is important when considering the use of this model to evaluate therapeutic outcomes directed toward vertebral metastasis...
  90. pmc Magnetic resonance imaging correlated with the histopathological effect of Pd-bacteriopheophorbide (Tookad) photodynamic therapy on the normal canine prostate gland
    Zheng Huang
    Radiation Oncology Department, University of Colorado at Denver and Health Sciences Center, Aurora, Colorado 80045, USA
    Lasers Surg Med 38:672-81. 2006
    ..To determine the optimal magnetic resonance imaging (MRI) methodology to assess photodynamic therapy (PDT)-induced histopathological responses in the prostate...
  91. pmc Studies of a vascular-acting photosensitizer, Pd-bacteriopheophorbide (Tookad), in normal canine prostate and spontaneous canine prostate cancer
    Zheng Huang
    HealthONE Alliance, Denver, Colorado 80203, USA
    Lasers Surg Med 36:390-7. 2005
    ..Photodynamic therapy (PDT) mediated with Tookad (Pd-bacteriopheophorbide, WST09) was investigated pre-clinically as part of a program to develop an alternative modality for treating prostate cancer...
  92. ncbi request reprint Endoscopic detection of early upper GI cancers
    Louis Michel Wong Kee Song
    Division of Gastroenterology and Hepatology, Mayo Clinic, 200 1st Street S W, Rochester, MN 55905, USA
    Best Pract Res Clin Gastroenterol 19:833-56. 2005
    ..The combination of novel diagnostic techniques and local endoscopic therapies will provide the endoscopist with much needed tools that can considerably enhance the detection and management of early stage lesions in the upper GI tract...
  93. pmc The effect of Tookad-mediated photodynamic ablation of the prostate gland on adjacent tissues--in vivo study in a canine model
    Zheng Huang
    AMC Cancer Research Center and Department of Radiation Oncology, Aurora, Colorado, USA
    Photochem Photobiol Sci 6:1318-24. 2007
    ..Direct intraurethral irradiation might provide an ideal means to determine the sensitivity of the prostatic urethra and might lead to transurethral PDT protocols for the management of benign prostatic hyperplasia (BHP)...
  94. ncbi request reprint Autofluorescence-based detection of early neoplasia in patients with Barrett's esophagus
    Mohammed Kara
    Department of Gastroenterology and Hepatology, Academic Medical Center, Amsterdam, The Netherlands
    Dig Dis 22:134-41. 2004
  95. ncbi request reprint Protease-triggered photosensitizing beacon based on singlet oxygen quenching and activation
    Juan Chen
    Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Am Chem Soc 126:11450-1. 2004
    ..Upon caspase-3-induced cleavage, the 1O2 production increased markedly, as measured directly by 1O2 near-infrared luminescence and lifetime measurements...
  96. ncbi request reprint Mapping ALA-induced PPIX fluorescence in normal brain and brain tumour using confocal fluorescence microscopy
    Malini Olivo
    Division of Medical Sciences, National Cancer Centre, Singapore 169610
    Int J Oncol 25:37-45. 2004
    ..Increased PPIX accumulation in tumour and inflamed brain tissue in comparison to normal brain tissue suggest the feasibility of selective photosensitization of such tissue...
  97. doi request reprint Effect of dimerization on vibrational spectra of eumelanin precursors
    Stephen P Nighswander-Rempel
    Centre for Biophotonics and Laser Science, School of Physical Sciences, University of Queensland, Brisbane, Queensland, Australia
    Photochem Photobiol 84:613-9. 2008
    ..Comparison of spectral features of the monomer and dimer provides insight into eumelanin photochemistry, but final conclusions depend on the planarity of oligomeric structure in vivo...
  98. ncbi request reprint The microenvironment effect on the generation of reactive oxygen species by Pd-bacteriopheophorbide
    Yahel Vakrat-Haglili
    Department of Plant Sciences, Weizmann Institute of Science, Rehovot, Israel
    J Am Chem Soc 127:6487-97. 2005
    ..The ability of bacteriochlorophyll (Bchl) derivatives to form such radicals upon excitation at the near infrared (NIR) domain opens new avenues in PDT and research of redox regulation in animals and plants...
  99. ncbi request reprint Photodynamic therapy for urological malignancies: past to current approaches
    Jehonathan H Pinthus
    Prostate Cancer Center, University Health Network and Department of Medical Biophysics, Ontario Cancer Institute, University of Toronto, Toronto, Ontario, Canada
    J Urol 175:1201-7. 2006
    ....
  100. ncbi request reprint New optical technologies for earlier endoscopic diagnosis of premalignant gastrointestinal lesions
    Ralph S Dacosta
    Department of Medical Biophysics, University of Toronto, Ontario Cancer Institute University Health Network, Canada
    J Gastroenterol Hepatol 17:S85-104. 2002
    ....
  101. ncbi request reprint Diagnostic potential of near-infrared Raman spectroscopy in the colon: differentiating adenomatous from hyperplastic polyps
    Andrea Molckovsky
    Department of Medical Biophysics, Ontario Cancer Institute University Health Network, University of Toronto, Toronto, Ontario, Canada
    Gastrointest Endosc 57:396-402. 2003
    ..This study assessed the diagnostic potential of near-infrared Raman spectroscopy in the colon by evaluating its ability to distinguish between adenomatous and hyperplastic polyps...