Research Topics
Genomes and GenesSpecies | Brian C WilsonSummaryAffiliation: University of Toronto Country: Canada Publications
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Publications
Spectroscopy and fluorescence in esophageal diseasesRalph S Dacosta
Department of Medical Biophysics, University of Toronto, Ontario Cancer Institute/University Health Network, Toronto, Ont, Canada
Best Pract Res Clin Gastroenterol 20:41-57. 2006..g. surface), and staging (e.g. depth) of dysplasia, thereby allowing timely cure by endoscopic means (e.g. EMR and/or PDT), biological interventions (e.g. Cox-2 inhibitors) rather than esophajectomy...- Feasibility of interstitial Doppler optical coherence tomography for in vivo detection of microvascular changes during photodynamic therapyHeng Li
Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada
Lasers Surg Med 38:754-61. 2006..This capability may play an important role in elucidating the mechanisms of PDT in tumors, pre-treatment planning, feedback control for treatment optimization, determining treatment endpoints and post-treatment assessments... - Potential applications of photodynamic therapy in regenerative medicineBrian C Wilson
Department of Medical Biophysics, Ontario Cancer Institute University Health Network, 610 University Avenue, Rm 7 417, Toronto, Ontario M5G 2M9, Canada
J Craniofac Surg 14:278-83. 2003..This paper presents the basic principles of PDT and considers some of the possible applications in regenerative medicine... 
The potential of biophotonic techniques in stem cell tracking and monitoring of tissue regeneration applied to cardiac stem cell therapyBrian C Wilson
Division of Biophysics and Bioimaging, University Health Network, 610 University Ave, Toronto, ON M5G 2M9, Canada
J Biophotonics 2:669-81. 2009..The scientific, technological, and logistics issues involved in moving some of these techniques from pre-clinical research mode ultimately into the clinic are also highlighted...- The physics, biophysics and technology of photodynamic therapyBrian C Wilson
Division of Biophysics and Bioimaging, Ontario Cancer Institute and Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada
Phys Med Biol 53:R61-109. 2008..The final section of the review introduces some new frontiers of research including low dose rate (metronomic) PDT, two-photon PDT, activatable PDT molecular beacons and nanoparticle-based PDT... - Detection and treatment of dysplasia in Barrett's esophagus: a pivotal challenge in translating biophotonics from bench to bedsideBrian C Wilson
University of Toronto, Ontario Cancer Institute, Division of Biophysics and Bioimaging, Toronto, Ontario, Canada
J Biomed Opt 12:051401. 2007..The future directions for this field are considered, particularly from the perspective of relying on intrinsic (endogenous) optical signatures compared with the use of exogenous contrast agents... - Photodynamic therapy for cancer: principlesBrian C Wilson
University of Toronto, Ontario Cancer Institute, Princess Margaret Hospital, 610 University Avenue, Toronto, Ontario M5G 2M9, Canada
Can J Gastroenterol 16:393-6. 2002..The fluorescence of many photosensitizers may be useful, either for (endoscopic) diagnosis or for PDT treatment guidance and monitoring... - Interstitial Doppler optical coherence tomography as a local tumor necrosis predictor in photodynamic therapy of prostatic carcinoma: an in vivo studyBeau A Standish
Department of Medical Biophysics and Radiation Oncology, University of Toronto, Ontario Cancer Institute University Health Network, Toronto, Canada
Cancer Res 68:9987-95. 2008.... - Interstitial Doppler optical coherence tomography monitors microvascular changes during photodynamic therapy in a Dunning prostate model under varying treatment conditionsBeau A Standish
Ontario Cancer Institute, University of Toronto, Department of Medical Biophysics, Toronto, Ontario M5G 2M9, Canada
J Biomed Opt 12:034022. 2007..These dependencies may play an important role in PDT treatment planning, feedback control for treatment optimization, and post-treatment assessment... - Treatment planning and dose analysis for interstitial photodynamic therapy of prostate cancerSean R H Davidson
Division of Biophysics and Bioimaging, Ontario Cancer Institute, University Health Network, 610 University Avenue, Toronto, Ontario M5G 2M9, Canada
Phys Med Biol 54:2293-313. 2009..The doses received by the urethra and the rectal wall were also investigated... - A tumor mRNA-triggered photodynamic molecular beacon based on oligonucleotide hairpin control of singlet oxygen productionJuan Chen
Division of Biophysics and Bioimaging, Ontario Cancer Institute, Toronto, Ontario M5G 1L7, Canada
Photochem Photobiol Sci 7:775-81. 2008..When incubated with c-raf-1 expressing MDA-MB-231 cancer cells, the PMB displayed efficient cellular uptake and subsequently effective PDT activation in targeted cells... - Defining the therapeutic window of vertebral photodynamic therapy in a murine pre-clinical model of breast cancer metastasis using the photosensitizer BPD-MA (Verteporfin)Margarete K Akens
Division of Orthopaedic Surgery, Sunnybrook Health Science Centre, Room E2 44, 2075 Bayview Ave, Toronto, ON M4N 3M5, Canada
Breast Cancer Res Treat 119:325-33. 2010..Overall, PDT represents an exciting potential new minimally-invasive local, safe and effective therapy in the management of patients with spinal metastases... 
Oxygen-independent degradation of HIF-alpha via bioengineered VHL tumour suppressor complexRoxana I Sufan
Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada
EMBO Mol Med 1:66-78. 2009..These findings introduce the concept and feasibility of 'bio-tailored' enzymes in the treatment of HIF-overexpressing tumours...- Fluorescence image-guided brain tumour resection with adjuvant metronomic photodynamic therapy: pre-clinical model and technology developmentArjen Bogaards
Division of Biophysics and Bioimaging, Ontario Cancer Institute, University Health Network and University of Toronto, Toronto, Ontario, M5G 2M9, Canada
Photochem Photobiol Sci 4:438-42. 2005..These results demonstrate that the combined treatment is technically feasible and this model is a candidate to evaluate it. Further optimization of mPDT treatment parameters (drug/light dose rates) is required to improve survival... - Beyond bisphosphonates: photodynamic therapy structurally augments metastatically involved vertebrae and destroys tumor tissueEmily Won
Orthopaedic Biomechanics Laboratory, Division of Orthopaedic Surgery, Sunnybrook Health Sciences Centre, Room UB 19, 2075 Bayview Ave, Toronto, ON M4N 3M5, Canada
Breast Cancer Res Treat 124:111-9. 2010..Overall, the ability of PDT to both ablate malignant tissue and improve the structural integrity of vertebral bone motivates its consideration as a local minimally invasive treatment for spinal metastasis secondary to breast cancer... - Endoscopic Doppler optical coherence tomography in the human GI tract: initial experienceVictor X D Yang
Faculty of Medicine, Department of Medical Biophysics, University of Toronto, Canada
Gastrointest Endosc 61:879-90. 2005..EDOCT may detect the different microcirculation patterns exhibited by normal and diseased tissues, which may be useful for diagnostic imaging and treatment monitoring... - Speckle variance detection of microvasculature using swept-source optical coherence tomographyAdrian Mariampillai
Department of Medical Biophysics, University of Toronto, Toronto, M5G 2M9, Canada
Opt Lett 33:1530-2. 2008.... - FRET quenching of photosensitizer singlet oxygen generationJonathan F Lovell
Institute of Biomaterials and Biomedical Engineering, Department of Medical Biophysics, University of Toronto, Canada
J Phys Chem B 113:3203-11. 2009..The presented findings show that FRET-based quenchers can potently decrease singlet oxygen production and therefore be used to facilitate the rational design of activatable photosensitizers... - Doppler optical coherence tomography monitoring of microvascular tissue response during photodynamic therapy in an animal model of Barrett's esophagusBeau A Standish
Department of Medical Biophysics, University of Toronto, Ontario Cancer Institute, Toronto, Ontario, Canada
Gastrointest Endosc 66:326-33. 2007.... - Drug and light dose responses to focal photodynamic therapy of single blood vessels in vivoMamta Khurana
University of Toronto, Division of Biophysics and Bioimaging, Department of Medical Biophysics, Ontario Cancer Institute, Toronto, Ontario M5G2M9, Canada
J Biomed Opt 14:064006. 2009..Demonstration of reciprocity over a wide range of DLP is important for further development of focal PDT treatments, such as the targeting of feeder vessels in 2-gamma PDT of AMD... - Polarization birefringence measurements for characterizing the myocardium, including healthy, infarcted, and stem-cell-regenerated tissuesMichael F G Wood
Ontario Cancer Institute, Division of Biophysics and Bioimaging, Toronto, Ontario, Canada
J Biomed Opt 15:047009. 2010.... - The influence of hypoxia on bioluminescence in luciferase-transfected gliosarcoma tumor cells in vitroEduardo H Moriyama
Division of Biophysics and Bioimaging Ontario Cancer Institute University of Toronto, 610 University Avenue 7 417, Toronto, Ontario M5G 2M9, Canada
Photochem Photobiol Sci 7:675-80. 2008.... - Beyond radiation therapy: photodynamic therapy maintains structural integrity of irradiated healthy and metastatically involved vertebrae in a pre-clinical in vivo modelVictor C K Lo
Orthopaedic Biomechanics Laboratory, Sunnybrook Research Institute, UB 55, 2075 Bayview Avenue, Toronto, ON M4N 3M5, Canada
Breast Cancer Res Treat 135:391-401. 2012.... - Vascular-targeted photodynamic therapy (padoporfin, WST09) for recurrent prostate cancer after failure of external beam radiotherapy: a study of escalating light dosesJohn Trachtenberg
Surgical Oncology, Ontario Cancer Institute Princess Margaret Hospital, Toronto, Canada
BJU Int 102:556-62. 2008.... - Proof-of-principle demonstration of a Mueller matrix decomposition method for polarized light tissue characterization in vivoMichael F G Wood
Ontario Cancer Institute, Division of Biophysics and Bioimaging, University Health Network, 610 University Avenue, Toronto, Ontario M5G 2M9 Canada
J Biomed Opt 14:014029. 2009..This study represents the first in vivo demonstration of a Mueller matrix decomposition method for polarimetric tissue characterization... - Using the singlet oxygen scavenging property of carotenoid in photodynamic molecular beacons to minimize photodamage to non-targeted cellsJuan Chen
Division of Biophysics and Bioimaging, Ontario Cancer Institute, Toronto, ON M5G 1L7, Canada
Photochem Photobiol Sci 6:1311-7. 2007..Moreover, the in vitro PDT response showed that CAR completely shuts off the photodynamic effect in non-targeted HepG(2) cells, while PS without CAR (control) remains highly potent even at a much lower (30-fold) dose... - Prostate tissue composition and MR measurements: investigating the relationships between ADC, T2, K(trans), v(e), and corresponding histologic featuresDeanna L Langer
Department of Medical Imaging, Princess Margaret Hospital, University Health Network and Mount Sinai Hospital, 610 University Ave, Room 3 958, Toronto, ON, Canada M5G 2M9
Radiology 255:485-94. 2010..To investigate relationships between magnetic resonance (MR) imaging measurements and the underlying composition of normal and malignant prostate tissue... - Assessment of photobleaching during endoscopic autofluorescence imaging of the lower GI tractAlexandre Douplik
Ontario Cancer Institute, Princess Margaret Hospital, University Health Network, Toronto, ON, Canada
Lasers Surg Med 42:224-31. 2010.... - Effects of photodynamic therapy on the structural integrity of vertebral boneEmily Won
Orthopaedic Biomechanics Laboratory, Division of Orthopaedics, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
Spine (Phila Pa 1976) 35:272-7. 2010..This study investigates the effects of photodynamic therapy (PDT) on the structural integrity of vertebral bone in healthy rats... - Quantitative in vitro demonstration of two-photon photodynamic therapy using photofrin and visudyneMamta Khurana
Department of Medical Biophysics, Ontario Cancer Institute, University of Toronto, Toronto, ON, Canada
Photochem Photobiol 83:1441-8. 2007.... - Imaging of specific activation of photodynamic molecular beacons in breast cancer vertebral metastasesTracy W Liu
Department of Medical Biophysics, University of Toronto, Canada
Bioconjug Chem 22:1021-30. 2011..Here, we validate that the metastasis-selective mechanism of PP(MMP)Bs can specifically image breast cancer vertebral metastases, thereby differentiating tumor and healthy tissue... - Techniques for delivery and monitoring of TOOKAD (WST09)-mediated photodynamic therapy of the prostate: clinical experience and practicalitiesRobert A Weersink
Laboratory for Applied Biophotonics, University Health Network, University Avenue, Toronto, Canada
J Photochem Photobiol B 79:211-22. 2005..Further development of these delivery and monitoring techniques will permit full on-line monitoring of the treatment that will enable real-time, patient-specific and optimized delivery of PDT... - Increased brain tumor resection using fluorescence image guidance in a preclinical modelArjen Bogaards
Department of Medical Biophysics, Ontario Cancer Institute/University Health Network and University of Toronto, Toronto, Ontario, Canada M5G 2M9
Lasers Surg Med 35:181-90. 2004..0+/-3.5% of the initial tumor volume. CONCLUSIONS: Additional FGR increased completeness of resection and enabled more consistent resections between cases... - Estimation of minimum doses for optimized quantum dot contrast-enhanced vascular imaging in vivoMathieu Roy
Department of Medical Biophysics, University of Toronto, 610 University Ave, Toronto, Ontario, Canada
Small 8:1780-92. 2012..It also proposes and validates a theoretical framework for QD dose estimation and quantifies the effects of blood absorption, QD emission wavelength, and vessel diameter relative to the threshold dose... - Effect of tissue optics on wavelength optimization for quantum dot-based surface and subsurface fluorescence imagingMathieu Roy
University of Toronto, Ontario Cancer Institute, Department of Medical Biophysics, 610 University Avenue, Toronto, Ontario, M5G 2M9 Canada
J Biomed Opt 17:026002. 2012..This work contributes to the development of robust and quantitative dosimetry for QD-based fluorescence imaging near to the tissue surface... - Hypoxia promotes ligand-independent EGF receptor signaling via hypoxia-inducible factor-mediated upregulation of caveolin-1Yi Wang
Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada M5S 1A8
Proc Natl Acad Sci U S A 109:4892-7. 2012.... - Insights into photodynamic therapy dosimetry: simultaneous singlet oxygen luminescence and photosensitizer photobleaching measurementsMark T Jarvi
Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada
Biophys J 102:661-71. 2012..These studies improve our understanding of PDT processes, demonstrate that SOL is a valuable gold-standard dose metric, and show that when used judiciously, photobleaching can serve as a surrogate for (1)O(2) dose... - Facile synthesis of advanced photodynamic molecular beacon architecturesJonathan F Lovell
Department of Medical Biophysics, Ontario Cancer Institute, University of Toronto, Ontario
Bioconjug Chem 21:1023-5. 2010..Linear superquenchers exhibited highly efficient quenching. This fully automated synthesis method simplifies not only the synthesis and purification of PMBs, but also the creation of new activatable photosensitizer designs... - Bioluminescence imaging of the response of rat gliosarcoma to ALA-PpIX-mediated photodynamic therapyEduardo H Moriyama
Department of Medical Biophysics, Ontario Cancer Institute, University of Toronto, Toronto M5G 2M9, Ontario, Canada
Photochem Photobiol 80:242-9. 2004..These results suggest that BLI can be used to provide spatiotemporal information of intracranial brain tumor responses after PDT and may serve as a valuable response-endpoint measure... - Photodynamic therapy of vertebral metastases: evaluating tumor-to-neural tissue uptake of BPD-MA and ALA-PpIX in a murine model of metastatic human breast carcinomaMargarete K Akens
Division of Orthopaedic Surgery, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
Photochem Photobiol 83:1034-9. 2007..The highest ratio for BPD-MA concentration was found 15 min after injection, which can be recommended for therapy in this model... - Fluorescence and spectral imagingRalph S Dacosta
Department of Medical Biophysics, University of Toronto, Ontario Cancer Institute, 610 University Avenue, Toronto, Ontario, M5G 2M9, Canada
ScientificWorldJournal 7:2046-71. 2007..e., quantum dots). This is an area of great promise, but still in its infancy, and preclinical studies are currently under way... - "Zipper" molecular beacons: a generalized strategy to optimize the performance of activatable protease probesJuan Chen
Department of Medical Biophysics, Ontario Cancer Institute, University of Toronto, Toronto, Ontario, Canada
Bioconjug Chem 20:1836-42. 2009..This ZMB concept is a generalizable approach to improve the functionality of a wide range of diagnostic/therapeutic probes through a simple switching of substrate sequences... - Pre-clinical in vitro and in vivo studies to examine the potential use of photodynamic therapy in the treatment of osteomyelitisStuart K Bisland
Ontario Cancer Institute, University Health Network, University of Toronto, 610 University Ave, Toronto, Canada
Photochem Photobiol Sci 5:31-8. 2006..In vivo, ALA-mediated PDT inhibited biofilm implants in bone. These results confirm that MB or ALA-mediated PDT have potential to treat S. aureus cultures grown in vitro or in vivo using an animal model of osteomyelitis... - Optimized speckle variance OCT imaging of microvasculatureAdrian Mariampillai
Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada
Opt Lett 35:1257-9. 2010..We also show svOCT imaging of the nonstabilized finger (high bulk motion), using optimized imaging parameters, demonstrating better vessel detection than Doppler OCT... - Quantification of in vivo fluorescence decoupled from the effects of tissue optical properties using fiber-optic spectroscopy measurementsAnthony Kim
University of Toronto, Department of Medical Biophysics, Toronto, Ontario, Canada
J Biomed Opt 15:067006. 2010..This technique is validated in phantoms and ex vivo mouse tissues, and tested in vivo in a rabbit brain tumor model using ALA-PpIX fluorescence contrast... - Porphyrin shell microbubbles with intrinsic ultrasound and photoacoustic propertiesElizabeth Huynh
Ontario Cancer Institute and Techna Institute, University Health Network, Toronto, Ontario, Canada M5G 1L7
J Am Chem Soc 134:16464-7. 2012..The distinctive properties of porshe MBs make them potentially advantageous for a broad range of biomedical imaging and therapeutic applications... - Photodynamic therapy of brain tumors--a work in progressPaul J Muller
Division of Neurosurgery, St Michael s Hospital, University of Toronto, Ontario, Canada
Lasers Surg Med 38:384-9. 2006..PDT has been used in the treatment of malignant brain tumors. This communication updates our series of unselected malignant gliomas treated with Photofrin-PDT... - Doppler optical coherence tomography with a micro-electro-mechanical membrane mirror for high-speed dynamic focus trackingVictor X D Yang
Ontario Cancer Institute, University Health Network, Toronto, Ontario, Canada
Opt Lett 31:1262-4. 2006..The mirror's small size (1.4 mm x 1 mm) will allow integration with endoscopic MEMS-DOCT for in vivo applications... - Interstitial Doppler optical coherence tomographyVictor X D Yang
University Health Network, Toronto, Ontario, Canada
Opt Lett 30:1791-3. 2005..To our knowledge, this is the first demonstration of Doppler OCT through a needle probe in interstitial applications to visualize deeply situated microcirculation... - Oncolytic targeting of renal cell carcinoma via encephalomyocarditis virusFrederik C Roos
Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada
EMBO Mol Med 2:275-88. 2010..These findings provide compelling pre-clinical evidence for the usage of EMCV in the treatment of CCRCC and potentially other tumours with elevated HIF/NF-kappaB-survival signature... - The influence of oxygen depletion and photosensitizer triplet-state dynamics during photodynamic therapy on accurate singlet oxygen luminescence monitoring and analysis of treatment dose responseMark T Jarvi
Department of Medical Biophysics, University of Toronto Ontario Cancer Institute, Toronto, ON, Canada
Photochem Photobiol 87:223-34. 2011..In vitro studies with both mTHPC and aminolevulinic acid-photosensitizer protoporphyrin IX demonstrate that rigorous analysis of SOL signal kinetics is then crucial in order to use SOL as an accurate and quantitative PDT dose metric... - Biodistribution and pharmacokinetic studies of a porphyrin dimer photosensitizer (oxdime) by fluorescence imaging and spectroscopy in mice bearing xenograft tumorsMamta Khurana
Department of Medical Biophysics, University of Toronto Ontario Cancer Institute, Toronto, ON Chemistry Research Laboratory, Department of Chemistry, Oxford University, Oxford OX1 3TA, UK Sunnybrook Research Institute, University of Toronto, Toronto, ON
Photochem Photobiol 88:1531-8. 2012..Significant quantities accumulated in the tumor, indicating that this PDT sensitizer may be promising for cancer treatment... - Hierarchical model of fibrillar collagen organization for interpreting the second-order susceptibility tensors in biological tissueAdam E Tuer
Department of Physics, University of Toronto, Toronto, Ontario, Canada
Biophys J 103:2093-105. 2012..From the P-SHG parameters of vertebrae tissue, a three-dimensional reconstruction of lamellae of intervertebral disk is presented... - Singlet oxygen luminescence dosimetry (SOLD) for photodynamic therapy: current status, challenges and future prospectsMark T Jarvi
Department of Medical Biophysics, Ontario Cancer Institute and University of Toronto, Toronto, Ontario, Canada
Photochem Photobiol 82:1198-210. 2006.... - Imaging of photodynamically generated singlet oxygen luminescence in vivoMark J Niedre
Department of Medical Biophysics, Ontario Cancer Institute and University of Toronto, Toronto, Ontario, Canada
Photochem Photobiol 81:941-3. 2005..We verify the strong oxygen-dependence of the signal and show that the images are near the practical resolution limit... - Photodynamic molecular beacon as an activatable photosensitizer based on protease-controlled singlet oxygen quenching and activationGang Zheng
Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada M5G 1L7
Proc Natl Acad Sci U S A 104:8989-94. 2007..Rather, it will depend on how selective a biomarker is to cancer cells, and how selective the interaction of PMB is to this biomarker... - Uroporphyrinogen decarboxylase is a radiosensitizing target for head and neck cancerEmma Ito
Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada M5G 2M9
Sci Transl Med 3:67ra7. 2011..Thus, our study has revealed UROD as a potent tumor-selective sensitizer for both radiation and chemotherapy, with potential relevance to many human malignancies... - Topographic mapping of subsurface fluorescent structures in tissue using multiwavelength excitationAnthony Kim
University of Toronto, Department of Medical Biophysics, Toronto, Ontario, Canada
J Biomed Opt 15:066026. 2010..This method has potential for fluorescence image-guided tumor surgery, as well as other biomedical and nonbiological applications in subsurface sensing... - Prostate gland: MR imaging appearance after vascular targeted photodynamic therapy with palladium-bacteriopheophorbideMasoom A Haider
Joint Department of Medical Imaging, Princess Margaret Hospital, University Health Network and Mount Sinai Hospital, University of Toronto, 610 University Ave, Toronto, ON, Canada
Radiology 244:196-204. 2007.... - Homogenized tissue phantoms for quantitative evaluation of subsurface fluorescence contrastMathieu Roy
University Health Network, University of Toronto and Ontario Cancer Institute, Department of Medical Biophysics, 610 University Avenue, Toronto, ON, M5G 2M9 Canada
J Biomed Opt 16:016013. 2011..The tissue homogenate method should be of value for quantitative optimization studies relevant to, for example, endoscopic imaging... - Diblock copolymer micelles deliver hydrophobic protoporphyrin IX for photodynamic therapyBuhong Li
Department of Medical Biophysics, University of Toronto, Ontario Cancer Institute University Health Network, Toronto, ON, Canada
Photochem Photobiol 83:1505-12. 2007..The micelles alone had no evident phototoxicity or dark toxicity. These findings suggest that MePEG(5000)-b-PCL(4100) diblock copolymer micelles have great potential as a drug delivery system for hydrophobic photodynamic sensitizers... - Prostate cancer detection with multi-parametric MRI: logistic regression analysis of quantitative T2, diffusion-weighted imaging, and dynamic contrast-enhanced MRIDeanna L Langer
Department of Medical Imaging, Princess Margaret Hospital, University Health Network and Mount Sinai Hospital, Toronto, Ontario, Canada
J Magn Reson Imaging 30:327-34. 2009..To develop a multi-parametric model suitable for prospectively identifying prostate cancer in peripheral zone (PZ) using magnetic resonance imaging (MRI)... - In vitro tests of the validity of singlet oxygen luminescence measurements as a dose metric in photodynamic therapyMark J Niedre
Department of Medical Biophysics, Ontario Cancer Institute/University Health Network, 610 University Avenue, Toronto, Ontario M5G 2M9, Canada
Cancer Res 63:7986-94. 2003..This study supports the validity and potential utility of (1)O(2) luminescence measurement as a dosimetric tool for PDT, as well as confirming the likely role of (1)O(2) in porphyrin-based PDT... - Micromachined array tip for multifocus fiber-based optical coherence tomographyVictor X D Yang
Department of Medical Biophysics, University of Toronto, Toronto, Ontario M5G 2M9, Canada
Opt Lett 29:1754-6. 2004.... - Continuous docetaxel chemotherapy improves therapeutic efficacy in murine models of ovarian cancerRaquel De Souza
Department of Pharmaceutical Sciences, University of Toronto, Ontario, Canada
Mol Cancer Ther 9:1820-30. 2010..Overall, our results show greater therapeutic advantages of continuous over intermittent chemotherapy in the treatment of ovarian cancer... - Feasibility study of autofluorescence mammary ductoscopyAlexandre Douplik
Ontario Cancer Institute, University Health Network, 7 417 610 University Avenue, Toronto, M5G 2M9 Canada
J Biomed Opt 14:044036. 2009..Point fluoroscopy is also performed. Although the optical "geometry" for this is different, the findings are consistent with the imaging observations... - Simultaneous two-photon excitation of photofrin in relation to photodynamic therapyAliaksandr Karotki
Division of Biophysics and Bioimaging, Ontario Cancer Institute, University of Toronto, Toronto, Ontario, Canada
Photochem Photobiol 82:443-52. 2006.... - Critical role for Fas-associated death domain-like interleukin-1-converting enzyme-like inhibitory protein in anoikis resistance and distant tumor formationImtiaz A Mawji
Ontario Cancer Institute, Princess Margaret Hospital, 610 University Ave, Toronto, ON, Canada, M5G 2M9
J Natl Cancer Inst 99:811-22. 2007..We hypothesized that c-Fas-associated death domain-like interleukin-1-converting enzyme-like inhibitory protein (FLIP), an endogenous inhibitor of death receptor signaling, may suppress anoikis... - Imaging the modulation of adenoviral kinetics and biodistribution for cancer gene therapyJoseph D Mocanu
Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada
Mol Ther 15:921-9. 2007..This study reports the favorable modulation by STI571 of the biodistribution of adenoviral vectors, providing a potential approach to improving therapeutic outcome... - A multispectral fluorescence imaging system: design and initial clinical tests in intra-operative Photofrin-photodynamic therapy of brain tumorsVictor X D Yang
Department of Medical Biophysics, University of Toronto, Canada
Lasers Surg Med 32:224-32. 2003..CONCLUSIONS: The system performed to specification under realistic operating conditions and could reveal unresected residual tumor tissue. It may be used for either PDT dosimetry/monitoring and/or for surgical guidance... - Optical techniques for the endoscopic detection of dysplastic colonic lesionsRalph S Dacosta
Department of Medical Biophysics, University of Toronto, Ontario Cancer Institute/University Health Network, Toronto, Ontario, Canada
Curr Opin Gastroenterol 21:70-9. 2005.... - Androgen induces adaptation to oxidative stress in prostate cancer: implications for treatment with radiation therapyJehonathan H Pinthus
The Prostate Cancer Center, University Health Network, Toronto, Ontario, Canada
Neoplasia 9:68-80. 2007..Thus, testosterone induces a preset cellular adaptation to radiation through the generation of elevated bROS, which is modified by AD. These findings provide a rational for combined hormonal and radiation therapy for localized PC... - Radiance-based monitoring of the extent of tissue coagulation during laser interstitial thermal therapyLee C Chin
Department of Medical Biophysics, University of Toronto, Ontario Cancer Institute, Toronto M5G 2M9, Canada
Opt Lett 29:959-61. 2004..We performed experiments with albumen phantoms to demonstrate the practicality of the radiance method for monitoring interstitial laser thermal therapy... - Metronomic photodynamic therapy as a new paradigm for photodynamic therapy: rationale and preclinical evaluation of technical feasibility for treating malignant brain tumorsStuart K Bisland
Ontario Cancer Institute, University Health Network, 610 University Avenue, Toronto, Ontario, Canada M5G 2M9
Photochem Photobiol 80:22-30. 2004..The combined delivery of both drug and light during an extended period, without compromising survival of the animals, is demonstrated. Preliminary evidence of selective apoptosis of tumor under these conditions is presented... - A new technique for physiodesis using photodynamic therapyStuart K Bisland
Princess Margaret Hospital, Department of Medical Physics, Uniersity Health Network, Toronto, Ontario, Canada
Clin Orthop Relat Res 461:153-61. 2007..At 4 weeks posttreatment, limbs were shortened by an average of 9.5% +/- 4.4% without complication, confirming the potential application of photodynamic therapy for physiodesis... - Assessment of cutaneous photosensitivity of TOOKAD (WST09) in preclinical animal models and in patientsRobert A Weersink
Laboratory for Applied Biophotonics, University Health Network, Toronto, Canada
Photochem Photobiol 81:106-13. 2005..Using the full spectrum of solar-simulated light, the presence of TOOKAD did not measurably enhance the UV(+)-induced erythema in the rats, pigs or patients... - Direct near-infrared luminescence detection of singlet oxygen generated by photodynamic therapy in cells in vitro and tissues in vivoMark Niedre
Department of Medical Biophysics, Ontario Cancer Institute/University of Toronto, Canada
Photochem Photobiol 75:382-91. 2002..We believe that these are the first direct observations of PDT-generated intracellular and in vivo 102. The detector technology provides a new tool for PDT research and possibly clinical use... - Mueller matrix decomposition for polarized light assessment of biological tissuesNirmalya Ghosh
Ontario Cancer Institute, Division of Biophysics and Bioimaging, University Health Network, Toronto, Ontario, Canada
J Biophotonics 2:145-56. 2009..Results demonstrate potential for both applications... - A fiberoptic reflectance probe with multiple source-collector separations to increase the dynamic range of derived tissue optical absorption and scattering coefficientsAnthony Kim
Department of Medical Biophysics, University of Toronto and Ontario Cancer Institute Campbell Family Institute for Cancer Research, University Health Network, 610 University Avenue, Toronto, Ontario, M5G 2M9, Canada
Opt Express 18:5580-94. 2010..The dynamic range and accuracy of this method were evaluated using Monte Carlo simulations, phantom experiments and tissues in vivo... - High throughput quantification of protein expression of cancer antigens in tissue microarray using quantum dot nanocrystalsArezou A Ghazani
Division of Applied Molecular Oncology, Ontario Cancer Institute, Toronto, Ontario M5G 2M9, Canada
Nano Lett 6:2881-6. 2006..The integration of this method for tissue analysis in the clinic bears potential impact for improving the diagnosis and treatment of cancer... - In vivo Doppler optical coherence tomography of mucocutaneous telangiectases in hereditary hemorrhagic telangiectasiaShou-Jiang Tang
Center for Therapeutic Endoscopy and Endoscopic Oncology, Division of Respiratory Medicine, Department of Medicine, St. Michael's Hospital, Ontario, Canada
Gastrointest Endosc 58:591-8. 2003..Mucocutaneous telangiectases with a history of bleeding were more superficial but were otherwise similar to mucocutaneous telangiectases with no bleeding history... - The effect of Tookad-mediated photodynamic ablation of the prostate gland on adjacent tissues--in vivo study in a canine modelZheng Huang
AMC Cancer Research Center and Department of Radiation Oncology, Aurora, Colorado, USA
Photochem Photobiol Sci 6:1318-24. 2007..Direct intraurethral irradiation might provide an ideal means to determine the sensitivity of the prostatic urethra and might lead to transurethral PDT protocols for the management of benign prostatic hyperplasia (BHP)... - Magnetic resonance imaging correlated with the histopathological effect of Pd-bacteriopheophorbide (Tookad) photodynamic therapy on the normal canine prostate glandZheng Huang
Radiation Oncology Department, University of Colorado at Denver and Health Sciences Center, Aurora, Colorado 80045, USA
Lasers Surg Med 38:672-81. 2006..To determine the optimal magnetic resonance imaging (MRI) methodology to assess photodynamic therapy (PDT)-induced histopathological responses in the prostate... - Preclinical studies in normal canine prostate of a novel palladium-bacteriopheophorbide (WST09) photosensitizer for photodynamic therapy of prostate cancersQun Chen
HealthONE Alliance, Denver, CO 80218, USA
Photochem Photobiol 76:438-45. 2002..Hence, Tookad-PDT appears to be a promising candidate for prostate ablation in patients with recurrent, or possibly even primary, prostate cancer... - Multimodality imaging for vertebral metastases in a rat osteolytic modelShane Burch
Department of Orthopaedic Surgery, University of California San Francisco, San Francisco, CA, USA
Clin Orthop Relat Res 454:230-6. 2007..Early identification of metastasis is important when considering the use of this model to evaluate therapeutic outcomes directed toward vertebral metastasis... - Complete blood vessel occlusion in the chick chorioallantoic membrane using two-photon excitation photodynamic therapy: implications for treatment of wet age-related macular degenerationKimberley S Samkoe
University of Calgary, Department of Chemistry, 2500 University Drive, Northwest, Calgary, Alberta T2N 1N4, Canada
J Biomed Opt 12:034025. 2007..Further investigation will help determine the utility of TPE-PDT for treating wet AMD, perhaps through targeting feeder vessels... - Effects of Pd-bacteriopheophorbide (TOOKAD)-mediated photodynamic therapy on canine prostate pretreated with ionizing radiationZheng Huang
HealthONE Alliance, Denver, Colorado 80203, USA
Radiat Res 161:723-31. 2004.... - Autofluorescence-based detection of early neoplasia in patients with Barrett's esophagusMohammed Kara
Department of Gastroenterology and Hepatology, Academic Medical Center, Amsterdam, The Netherlands
Dig Dis 22:134-41. 2004 - Endoscopic detection of early upper GI cancersLouis Michel Wong Kee Song
Division of Gastroenterology and Hepatology, Mayo Clinic, 200 1st Street S W, Rochester, MN 55905, USA
Best Pract Res Clin Gastroenterol 19:833-56. 2005..The combination of novel diagnostic techniques and local endoscopic therapies will provide the endoscopist with much needed tools that can considerably enhance the detection and management of early stage lesions in the upper GI tract... - Mapping ALA-induced PPIX fluorescence in normal brain and brain tumour using confocal fluorescence microscopyMalini Olivo
Division of Medical Sciences, National Cancer Centre, Singapore 169610
Int J Oncol 25:37-45. 2004..Increased PPIX accumulation in tumour and inflamed brain tissue in comparison to normal brain tissue suggest the feasibility of selective photosensitization of such tissue... - Studies of a vascular-acting photosensitizer, Pd-bacteriopheophorbide (Tookad), in normal canine prostate and spontaneous canine prostate cancerZheng Huang
HealthONE Alliance, Denver, Colorado 80203, USA
Lasers Surg Med 36:390-7. 2005..Photodynamic therapy (PDT) mediated with Tookad (Pd-bacteriopheophorbide, WST09) was investigated pre-clinically as part of a program to develop an alternative modality for treating prostate cancer... - Protease-triggered photosensitizing beacon based on singlet oxygen quenching and activationJuan Chen
Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA
J Am Chem Soc 126:11450-1. 2004..Upon caspase-3-induced cleavage, the 1O2 production increased markedly, as measured directly by 1O2 near-infrared luminescence and lifetime measurements... - The potential of autofluorescence for the detection of single living cells for label-free cell sorting in microfluidic systemsJurjen Emmelkamp
Mesa Institute, Lab on a Chip Group, University of Twente, Enschede, The Netherlands
Electrophoresis 25:3740-5. 2004..Hence, the combined use of microfluidic devices and cell AF may have many applications in single-cell analysis... - Diagnostic potential of near-infrared Raman spectroscopy in the colon: differentiating adenomatous from hyperplastic polypsAndrea Molckovsky
Department of Medical Biophysics, Ontario Cancer Institute/University Health Network, University of Toronto, Toronto, Ontario, Canada
Gastrointest Endosc 57:396-402. 2003..To our knowledge, this is the first demonstration of the potential of near-infrared Raman spectroscopy for differentiation of colonic polyps during GI endoscopy... - Effect of dimerization on vibrational spectra of eumelanin precursorsStephen P Nighswander-Rempel
Centre for Biophotonics and Laser Science, School of Physical Sciences, University of Queensland, Brisbane, Queensland, Australia
Photochem Photobiol 84:613-9. 2008..Comparison of spectral features of the monomer and dimer provides insight into eumelanin photochemistry, but final conclusions depend on the planarity of oligomeric structure in vivo... - New optical technologies for earlier endoscopic diagnosis of premalignant gastrointestinal lesionsRalph S Dacosta
Department of Medical Biophysics, University of Toronto, Ontario Cancer Institute/University Health Network, Canada
J Gastroenterol Hepatol 17:S85-104. 2002.... - Photodynamic therapy for urological malignancies: past to current approachesJehonathan H Pinthus
Prostate Cancer Center, University Health Network and Department of Medical Biophysics, Ontario Cancer Institute, University of Toronto, Toronto, Ontario, Canada
J Urol 175:1201-7. 2006..However, ongoing preclinical work and clinical trials indicate that safer and effective PDT treatments in uro-oncology are imminent... - The microenvironment effect on the generation of reactive oxygen species by Pd-bacteriopheophorbideYahel Vakrat-Haglili
Department of Plant Sciences, Weizmann Institute of Science, Rehovot, Israel
J Am Chem Soc 127:6487-97. 2005..The ability of bacteriochlorophyll (Bchl) derivatives to form such radicals upon excitation at the near infrared (NIR) domain opens new avenues in PDT and research of redox regulation in animals and plants...