Duminda N Wijeysundera

Summary

Affiliation: University of Toronto
Country: Canada

Publications

  1. doi request reprint A population-based study of anesthesia consultation before major noncardiac surgery
    Duminda N Wijeysundera
    Department of Anesthesia, Toronto General Hospital and University of Toronto, ON, Canada
    Arch Intern Med 169:595-602. 2009
  2. doi request reprint Outcomes and processes of care related to preoperative medical consultation
    Duminda N Wijeysundera
    Institute for Clinical Evaluative Sciences, Keenan Research Centre, Li Ka Shing Knowledge Institute of St Michael s Hospital, Department of Anesthesia, Toronto General Hospital and University of Toronto, EN 3 450, 200 Elizabeth St, Toronto, ON M5G 2C4, Canada
    Arch Intern Med 170:1365-74. 2010
  3. doi request reprint Duration of preoperative β-blockade and outcomes after major elective noncardiac surgery
    Duminda N Wijeysundera
    Li Ka Shing Knowledge Institute of St Michael s Hospital, Toronto, Ontario, Canada Department of Anesthesia, Toronto General Hospital and University of Toronto, Toronto, Ontario, Canada Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada Institute of Health Policy Management and Evaluation, University of Toronto, Toronto, Ontario, Canada Electronic address
    Can J Cardiol 30:217-23. 2014
  4. doi request reprint Clinical evidence, practice guidelines, and β-blocker utilization before major noncardiac surgery
    Duminda N Wijeysundera
    St Michael s Hospital, Toronto, Ontario, Canada
    Circ Cardiovasc Qual Outcomes 5:558-65. 2012
  5. doi request reprint Risk of elective major noncardiac surgery after coronary stent insertion: a population-based study
    Duminda N Wijeysundera
    Li Ka Shing Knowledge Institute of St Michael s Hospital, 30 Bond Street, Toronto, Ontario, M5B 1W8, Canada
    Circulation 126:1355-62. 2012
  6. doi request reprint Variation in the practice of preoperative medical consultation for major elective noncardiac surgery: a population-based study
    Duminda N Wijeysundera
    Li Ka Shing Knowledge Institute, St Michael s Hospital, Toronto, Ontario, Canada
    Anesthesiology 116:25-34. 2012
  7. pmc Non-invasive cardiac stress testing before elective major non-cardiac surgery: population based cohort study
    Duminda N Wijeysundera
    Institute for Clinical Evaluative Sciences, Toronto, Ontario M4N 3M5, Canada
    BMJ 340:b5526. 2010
  8. doi request reprint Bayesian statistical inference enhances the interpretation of contemporary randomized controlled trials
    Duminda N Wijeysundera
    Department of Health Policy Management and Evaluation, University of Toronto, Toronto, Ontario, Canada
    J Clin Epidemiol 62:13-21.e5. 2009
  9. doi request reprint Development of an algorithm to identify preoperative medical consultations using administrative data
    Duminda N Wijeysundera
    Institute for Clinical Evaluative Sciences, Toronto, ON, Canada
    Med Care 47:1258-64. 2009
  10. doi request reprint Preoperative consultations by anesthesiologists
    Duminda N Wijeysundera
    Keenan Research Centre, Li Ka Shing Knowledge Institute of St Michael s Hospital, and Department of Anesthesia, University of Toronto, Toronto, Ontario, Canada
    Curr Opin Anaesthesiol 24:326-30. 2011

Detail Information

Publications52

  1. doi request reprint A population-based study of anesthesia consultation before major noncardiac surgery
    Duminda N Wijeysundera
    Department of Anesthesia, Toronto General Hospital and University of Toronto, ON, Canada
    Arch Intern Med 169:595-602. 2009
    ..Nonetheless, the impact of anesthesia consultation on outcomes in the population remains unclear...
  2. doi request reprint Outcomes and processes of care related to preoperative medical consultation
    Duminda N Wijeysundera
    Institute for Clinical Evaluative Sciences, Keenan Research Centre, Li Ka Shing Knowledge Institute of St Michael s Hospital, Department of Anesthesia, Toronto General Hospital and University of Toronto, EN 3 450, 200 Elizabeth St, Toronto, ON M5G 2C4, Canada
    Arch Intern Med 170:1365-74. 2010
    ..Nonetheless, the impact of these consultations, which may be performed by general internists or specialists, on outcomes is unclear...
  3. doi request reprint Duration of preoperative β-blockade and outcomes after major elective noncardiac surgery
    Duminda N Wijeysundera
    Li Ka Shing Knowledge Institute of St Michael s Hospital, Toronto, Ontario, Canada Department of Anesthesia, Toronto General Hospital and University of Toronto, Toronto, Ontario, Canada Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada Institute of Health Policy Management and Evaluation, University of Toronto, Toronto, Ontario, Canada Electronic address
    Can J Cardiol 30:217-23. 2014
    ..Although practice guidelines recommend that perioperative β-blockade be initiated at least several days to weeks before noncardiac surgery is performed, the minimum required period of preoperative therapy is unclear...
  4. doi request reprint Clinical evidence, practice guidelines, and β-blocker utilization before major noncardiac surgery
    Duminda N Wijeysundera
    St Michael s Hospital, Toronto, Ontario, Canada
    Circ Cardiovasc Qual Outcomes 5:558-65. 2012
    ..However, subsequent studies raised concerns about a widespread use of perioperative β-blockade. Little is known regarding how this changing evidence influenced the use of perioperative β-blockers in clinical practice...
  5. doi request reprint Risk of elective major noncardiac surgery after coronary stent insertion: a population-based study
    Duminda N Wijeysundera
    Li Ka Shing Knowledge Institute of St Michael s Hospital, 30 Bond Street, Toronto, Ontario, M5B 1W8, Canada
    Circulation 126:1355-62. 2012
    ..Guidelines recommend that noncardiac surgery be delayed until 30 to 45 days after bare-metal stent implantation and 1 year after drug-eluting stent implantation...
  6. doi request reprint Variation in the practice of preoperative medical consultation for major elective noncardiac surgery: a population-based study
    Duminda N Wijeysundera
    Li Ka Shing Knowledge Institute, St Michael s Hospital, Toronto, Ontario, Canada
    Anesthesiology 116:25-34. 2012
    ..However, the factors that determine whether individuals undergo consultation and the extent of interhospital variation remain unclear...
  7. pmc Non-invasive cardiac stress testing before elective major non-cardiac surgery: population based cohort study
    Duminda N Wijeysundera
    Institute for Clinical Evaluative Sciences, Toronto, Ontario M4N 3M5, Canada
    BMJ 340:b5526. 2010
    ..To determine the association of non-invasive cardiac stress testing before elective intermediate to high risk non-cardiac surgery with survival and hospital stay...
  8. doi request reprint Bayesian statistical inference enhances the interpretation of contemporary randomized controlled trials
    Duminda N Wijeysundera
    Department of Health Policy Management and Evaluation, University of Toronto, Toronto, Ontario, Canada
    J Clin Epidemiol 62:13-21.e5. 2009
    ..Frequentist methods have limitations that might be overcome, in part, by Bayesian inference. To illustrate these advantages, we re-analyzed randomized trials published in four general medical journals during 2004...
  9. doi request reprint Development of an algorithm to identify preoperative medical consultations using administrative data
    Duminda N Wijeysundera
    Institute for Clinical Evaluative Sciences, Toronto, ON, Canada
    Med Care 47:1258-64. 2009
    ..However, administrative data in many jurisdictions lack specific codes to identify preoperative medical consultations, as opposed to consultations for nonoperative indications...
  10. doi request reprint Preoperative consultations by anesthesiologists
    Duminda N Wijeysundera
    Keenan Research Centre, Li Ka Shing Knowledge Institute of St Michael s Hospital, and Department of Anesthesia, University of Toronto, Toronto, Ontario, Canada
    Curr Opin Anaesthesiol 24:326-30. 2011
    ..The goal of this review is to discuss the implications of recent studies that have evaluated the processes-of-care and outcomes related to preoperative anesthesia consultation...
  11. ncbi request reprint Determinants of complications with recombinant factor VIIa for refractory blood loss in cardiac surgery
    Keyvan Karkouti
    University of Toronto, University Health Network, Department of Anesthesia, 3 Eaton North, 200 Elizabeth Street, Toronto, Ontario M5G 2C4, Canada
    Can J Anaesth 53:802-9. 2006
    ..Recombinant factor VIIa (rFVIIa) is being used for refractory, excessive blood loss (EBL) after cardiac surgery, but its safety for this indication is not known...
  12. doi request reprint The risk-benefit profile of aprotinin versus tranexamic acid in cardiac surgery
    Keyvan Karkouti
    Department of Anesthesia, University of Toronto, and Toronto General Hospital, Toronto, ON, Canada M5G 2C4
    Anesth Analg 110:21-9. 2010
    ..It remains unclear whether its risk-benefit profile differs among low-, moderate-, and high-risk cardiac surgical patients...
  13. doi request reprint Acute surgical anemia influences the cardioprotective effects of beta-blockade: a single-center, propensity-matched cohort study
    W Scott Beattie
    Department of Health Policy Management and Evaluation, University of Toronto, Toronto, Ontario, Canada
    Anesthesiology 112:25-33. 2010
    ....
  14. doi request reprint Acute kidney injury after cardiac surgery: focus on modifiable risk factors
    Keyvan Karkouti
    Department of Anesthesia and Health Policy, Management, and Evaluation, Toronto General Hospital, University of Toronto, 200 Elizabeth St, EN 3 402, Toronto, Ontario, Canada M5G 2C4
    Circulation 119:495-502. 2009
    ..Lacking effective therapies, risk factor modification may offer a means of preventing this complication. The objective of the present study was to identify and determine the prognostic importance of such risk factors...
  15. pmc Factors associated with colonoscopy performed in nonhospital settings
    Othman Alharbi
    Department of Medicine, Division of Gastroenterology, Sunnybrook Health Services Centre, Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada
    Can J Gastroenterol 24:419-24. 2010
    ..Regulation of these facilities is variable, and concerns regarding the quality of procedures in nonhospital (NH) settings have been raised. Further study is needed to better understand endoscopic practice in these facilities...
  16. ncbi request reprint Prognostic value of postoperative proteinuria in cardiac surgery: a pilot study
    Keyvan Karkouti
    University Health Network, Toronto General Hospital, Department of Anesthesia, EN 3 402, 200 Elizabeth Street, Toronto, Ontario M5G 2C4, Canada
    Can J Anaesth 53:500-6. 2006
    ..The objective of this pilot study was to determine if postoperative proteinuria is associated with adverse outcomes following cardiac surgery with cardiopulmonary bypass...
  17. doi request reprint Influence of erythrocyte transfusion on the risk of acute kidney injury after cardiac surgery differs in anemic and nonanemic patients
    Keyvan Karkouti
    Department of Anesthesia, Toronto General Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada
    Anesthesiology 115:523-30. 2011
    ..Two important risk factors for AKI are preoperative anemia and perioperative erythrocyte transfusion, and elucidating their relationship may help in devising preventive strategies...
  18. doi request reprint The incremental value of thrombelastography for prediction of excessive blood loss after cardiac surgery: an observational study
    Marcin Wasowicz
    Toronto General Hospital, 200 Elizabeth St, 3EN 402 Toronto, ON, Canada M5G 2C4
    Anesth Analg 111:331-8. 2010
    ..Accurate risk stratification may help reduce the burden of excessive blood loss after cardiac surgery. We measured the incremental value of thrombelastography to an existing risk prediction model for excessive blood loss in cardiac surgery...
  19. ncbi request reprint Improving the identification of patients at risk of postoperative renal failure after cardiac surgery
    Duminda N Wijeysundera
    Department of Anesthesia, Toronto General Hospital and University of Toronto, Ontario, Canada
    Anesthesiology 104:65-72. 2006
    ..Calculated creatinine clearance (CrCl) is an alternative measure of renal function that may allow better estimation of renal reserve...
  20. ncbi request reprint Derivation of a risk index for the prediction of massive blood transfusion in liver transplantation
    Stuart A McCluskey
    Department of Anesthesia and Pain Management, University of Toronto, Toronto, Ontario, Canada
    Liver Transpl 12:1584-93. 2006
    ..The ROC for this risk index was 0.79. MBT in liver transplantation surgery can be accurately predicted by 7 readily available preoperative predictors...
  21. doi request reprint The Revised Cardiac Risk Index in the new millennium: a single-centre prospective cohort re-evaluation of the original variables in 9,519 consecutive elective surgical patients
    Christopher Davis
    Department of Anesthesia, University of Toronto and the Peter Munk Cardiac Centre, Toronto, ON, Canada
    Can J Anaesth 60:855-63. 2013
    ..The Revised Cardiac Risk Index (RCRI) has become a standard for predicting post-surgical cardiac complications. This study re-examined the original six risk factors to confirm their validity in a large modern prospective database...
  22. doi request reprint Use of clinically based troponin underestimates the cardiac injury in non-cardiac surgery: a single-centre cohort study in 51,701 consecutive patients
    W Scott Beattie
    Department of Anesthesia and Pain Management, University Health Network, Toronto, ON, Canada
    Can J Anaesth 59:1013-22. 2012
    ....
  23. doi request reprint Advance targeted transfusion in anemic cardiac surgical patients for kidney protection: an unblinded randomized pilot clinical trial
    Keyvan Karkouti
    Department of Anesthesia and Institute of Health Policy, Management, and Evaluation, University of Toronto, Toronto, Ontario, Canada
    Anesthesiology 116:613-21. 2012
    ..Prophylactic erythrocyte transfusion in anemic patients may, therefore, protect against AKI...
  24. ncbi request reprint Calcium antagonists are associated with reduced mortality after cardiac surgery: a propensity analysis
    Duminda N Wijeysundera
    Department of Anesthesia, University of Toronto, EN 3 453, Toronto General Hospital, 200 Elizabeth Street, Toronto, Ontario M5G 2C4, Canada
    J Thorac Cardiovasc Surg 127:755-62. 2004
    ..We therefore performed a prospective observational cohort study of the effects of calcium channel blockers on cardiac surgical mortality. A propensity score technique was used for risk adjustment...
  25. ncbi request reprint Variability and predictability of large-volume red blood cell transfusion in cardiac surgery: a multicenter study
    Keyvan Karkouti
    University Health Network, Toronto General Hospital, Department of Anesthesia, Ontario, Canada
    Transfusion 47:2081-8. 2007
    ..The objectives of this study were to measure the interinstitution variation and predictability of large-volume RBC transfusion...
  26. pmc Association of echocardiography before major elective non-cardiac surgery with postoperative survival and length of hospital stay: population based cohort study
    Duminda N Wijeysundera
    Keenan Research Centre, Li Ka Shing Knowledge Institute of St Michael s Hospital, 80 Bond Street, Toronto, ON, Canada
    BMJ 342:d3695. 2011
    ..To determine the association of resting echocardiography before elective intermediate to high risk non-cardiac surgery with survival and length of hospital stay...
  27. doi request reprint N-acetylcysteine is associated with increased blood loss and blood product utilization during cardiac surgery
    Duminda N Wijeysundera
    Department of Anesthesia, Toronto General Hospital and University of Toronto, Toronto, Ontario, Canada
    Crit Care Med 37:1929-34. 2009
    ..We, therefore, performed a post hoc analysis of a recent randomized controlled trial in cardiac surgery to determine whether N-acetylcysteine was associated with increased blood loss and blood product transfusion...
  28. ncbi request reprint Calcium channel blockers for reducing cardiac morbidity after noncardiac surgery: a meta-analysis
    Duminda N Wijeysundera
    Department of Anesthesia, University of Toronto, ON
    Anesth Analg 97:634-41. 2003
    ..The majority of these benefits are attributable to diltiazem, suggesting the need for further evaluation of this drug in a large RCT...
  29. doi request reprint Rates and risk factors for prolonged opioid use after major surgery: population based cohort study
    Hance Clarke
    Department of Anesthesia and Pain Management, Toronto General Hospital, 200 Elizabeth Street, Eaton North 3 EB 317, Toronto, ON, Canada, M5G 2C4
    BMJ 348:g1251. 2014
    ..To describe rates and risk factors for prolonged postoperative use of opioids in patients who had not previously used opioids and undergoing major elective surgery...
  30. doi request reprint Risk associated with preoperative anemia in noncardiac surgery: a single-center cohort study
    W Scott Beattie
    Department of Anesthesia, University Health Network, Toronto General Hospital, Toronto, Ontario, Canada
    Anesthesiology 110:574-81. 2009
    ..The objective of this observational study was to measure the prevalence of preoperative anemia and assess the relationship between preoperative anemia and postoperative mortality...
  31. ncbi request reprint The independent association of massive blood loss with mortality in cardiac surgery
    Keyvan Karkouti
    Department of Anesthesia, University of Toronto, Toronto, Ontario, Canada
    Transfusion 44:1453-62. 2004
    ..The objective of this cohort study was to quantify the independent association of MBL in cardiac surgery with all-cause in-hospital mortality...
  32. doi request reprint Epidural anaesthesia and survival after intermediate-to-high risk non-cardiac surgery: a population-based cohort study
    Duminda N Wijeysundera
    Department of Health Policy Management and Evaluation, University of Toronto, Toronto, ON, Canada
    Lancet 372:562-9. 2008
    ..We therefore undertook a population-based cohort study to determine whether perioperative epidural anaesthesia or analgesia is associated with improved 30-day survival...
  33. doi request reprint Risk associated with preoperative anemia in cardiac surgery: a multicenter cohort study
    Keyvan Karkouti
    Department of Anesthesia, University Health Network, University of Toronto, Toronto, Ontario, Canada, M5G 2C4
    Circulation 117:478-84. 2008
    ..Whether preoperative anemia also is an independent risk factor for adverse outcomes after cardiac surgery, however, has not been fully elucidated...
  34. doi request reprint A population-based analysis of outpatient colonoscopy in adults assisted by an anesthesiologist
    Othman Alharbi
    Department of Medicine, Division of Gastroenterology, University of Toronto, Sunnybrook Health Sciences Centre, 2075 Bayview Ave, Toronto, Ontario, Canada
    Anesthesiology 111:734-40. 2009
    ..This study's objective was to identify nonpayor factors (patient, physician, institution) associated with anesthesiologist assistance at colonoscopy...
  35. ncbi request reprint Platelet transfusions are not associated with increased morbidity or mortality in cardiac surgery
    Keyvan Karkouti
    Department of Anesthesia, University Health Network, University of Toronto, Toronto, Ontario, Canada
    Can J Anaesth 53:279-87. 2006
    ..To determine the independent relationship between leukoreduced platelet transfusions and adverse events in cardiac surgery...
  36. doi request reprint The influence of baseline hemoglobin concentration on tolerance of anemia in cardiac surgery
    Keyvan Karkouti
    Department of Anesthesia, University Health Network, University of Toronto, Toronto, Ontario, Canada
    Transfusion 48:666-72. 2008
    ..Nonetheless, "normal" Hb concentrations vary widely in the population, and this variability may influence patients' tolerance of acute anemia. This retrospective cohort study was carried out to test this hypothesis...
  37. doi request reprint Does tight heart rate control improve beta-blocker efficacy? An updated analysis of the noncardiac surgical randomized trials
    W Scott Beattie
    Department of Anesthesia, Toronto General Hospital and University of Toronto, EN 3 450 200 Elizabeth St, Toronto, Ontario M5G 2C4, Canada
    Anesth Analg 106:1039-48, table of contents. 2008
    ..Tight control of heart rate (HR) has been suggested to improve these outcomes. Meta-analyses have not considered the influence of tight HR control on the efficacy of perioperative beta-blockade...
  38. ncbi request reprint A propensity score case-control comparison of aprotinin and tranexamic acid in high-transfusion-risk cardiac surgery
    Keyvan Karkouti
    Department of Anesthesia, University of Toronto, Toronto, Ontario, Canada
    Transfusion 46:327-38. 2006
    ..Prophylactic use of the antifibrinolytic drugs aprotinin and tranexamic acid is thought to prevent these hemostatic defects. Their relative clinical utility and safety in high-transfusion-risk cardiac surgery, however, is not known...
  39. ncbi request reprint N-acetylcysteine for preventing acute kidney injury in cardiac surgery patients with pre-existing moderate renal insufficiency
    Duminda N Wijeysundera
    Department of Anesthesia, Toronto General Hospital and University of Toronto, EN 3 450, 200 Elizabeth Street, Toronto, Ontario M5G 2C4, Canada
    Can J Anaesth 54:872-81. 2007
    ..To determine if N-acetylcysteine warrants definitive evaluation in a large multicentre trial, we evaluated its effects on a surrogate outcome, estimated glomerular filtration rate (eGFR), in a randomized trial...
  40. ncbi request reprint Off-pump coronary artery surgery for reducing mortality and morbidity: meta-analysis of randomized and observational studies
    Duminda N Wijeysundera
    Department of Anesthesia, Toronto General Hospital, Toronto, Ontario, Canada
    J Am Coll Cardiol 46:872-82. 2005
    ..The purpose of this study was to assess the effects of off-pump coronary bypass surgery (OPCAB) on mortality and morbidity...
  41. doi request reprint Systematic review: prediction of perioperative cardiac complications and mortality by the revised cardiac risk index
    Meredith K Ford
    Toronto General Hospital and University of Toronto, Toronto, Ontario, Canada
    Ann Intern Med 152:26-35. 2010
    ..The Revised Cardiac Risk Index (RCRI) is widely used to predict perioperative cardiac complications...
  42. doi request reprint Selective β1-antagonism with bisoprolol is associated with fewer postoperative strokes than atenolol or metoprolol: a single-center cohort study of 44,092 consecutive patients
    Catherine Ashes
    Cardiac Anesthesia Fellow, Department of Anesthesia, University Health Network, Toronto, Ontario, Canada Cardiac Anesthesia Fellow, Department of Anesthesia, St Michaels Hospital and the University of Toronto, Toronto, Ontario, Canada Assistant Professor, Department of Anesthesia, University Health Network Li Ka Shing Knowledge Institute of St Michael s Hospital Institute of Health Policy Management and Evaluation and University of Toronto Assistant Professor, Department of Anesthesia, University Health Network, and University of Toronto Professor, Department of Anesthesia, St Michaels Hospital and the University of Toronto, and Li Ka Shing Knowledge Institute of St Michael s Hospital Associate Professor, Department of Anesthesia, St Michaels Hospital and the University of Toronto, and Li Ka Shing Knowledge Institute of St Michael s Hospital Professor, Department of Anesthesia, University Health Network The Peter Munk Cardiac Centre within Toronto General Hospital, Toronto, Ontario, Canada and University of Toronto
    Anesthesiology 119:777-87. 2013
    ..The authors therefore conducted a cohort to study whether the highly β(1)-specific β-blocker (bisoprolol) was associated with a reduced risk of postoperative stroke compared with less selective β-blockers (metoprolol or atenolol)...
  43. ncbi request reprint Alpha-2 adrenergic agonists to prevent perioperative cardiovascular complications: a meta-analysis
    Duminda N Wijeysundera
    Department of Anesthesia, University Health Network, Ontario, Toronto, Canada
    Am J Med 114:742-52. 2003
    ..To investigate the effects of alpha(2)-adrenergic agonists on perioperative mortality and cardiovascular complications in adults undergoing surgery...
  44. ncbi request reprint Derivation and validation of a simplified predictive index for renal replacement therapy after cardiac surgery
    Duminda N Wijeysundera
    Department of Anesthesia, Toronto General Hospital and University of Toronto, Toronto, Ontario, Canada
    JAMA 297:1801-9. 2007
    ..A predictive index for renal replacement therapy (RRT; hemodialysis or continuous venovenous hemodiafiltration) after cardiac surgery may improve clinical decision making and research design...
  45. ncbi request reprint Calcium antagonists reduce cardiovascular complications after cardiac surgery: a meta-analysis
    Duminda N Wijeysundera
    Department of Anesthesia, University of Toronto, Toronto, Ontario, Canada
    J Am Coll Cardiol 41:1496-505. 2003
    ..We sought to determine the efficacy of calcium antagonists (CAs) in reducing death, myocardial infarction (MI), ischemia, and supraventricular tachyarrhythmia (SVT) after cardiac surgery...
  46. doi request reprint Relationship of erythrocyte transfusion with short- and long-term mortality in a population-based surgical cohort
    Keyvan Karkouti
    Department of Anesthesia, Toronto General Hospital, University Health Network, Institute of Health Policy, Management, and Evaluation, University of Toronto, Toronto, Ontario, Canada
    Anesthesiology 117:1175-83. 2012
    ..Nonetheless, unmeasured confounding may unduly influence this comparison. This unmeasured risk may have less influence on comparisons of patients undergoing surgery at hospitals with differing transfusion rates...
  47. doi request reprint Gender differences in mortality following non-cardiovascular surgery: an observational study
    Keerat Grewal
    Department of Anesthesia and Pain Management, Toronto General Hospital, 200 Elizabeth Street, Toronto, Ontario, Canada
    Can J Anaesth 59:255-62. 2012
    ..The objective of the study was to determine whether there are differences in mortality between males and females following non-cardiovascular surgery and to ascertain to what extent preoperative risk factors explain these differences...
  48. ncbi request reprint A meta-analytic comparison of preoperative stress echocardiography and nuclear scintigraphy imaging
    W Scott Beattie
    Department of Anesthesia and Pain Management University Health Network Toronto General Hospital, University of Toronto, Toronto, Ontario
    Anesth Analg 102:8-16. 2006
    ..A moderate-to-large perfusion defect by either SE or TI predicts postoperative MI and death. We conclude the SE is superior to TI in predicting postoperative cardiac events...
  49. ncbi request reprint Renal dysfunction in high-risk patients after on-pump and off-pump coronary artery bypass surgery: a propensity score analysis
    Andrew Chukwuemeka
    Division of Cardiovascular Surgery, Department of Surgery, University of Toronto, Toronto, Ontario, Canada
    Ann Thorac Surg 80:2148-53. 2005
    ..We attempted to determine whether off-pump coronary artery bypass grafting surgery prevents postoperative renal dysfunction in patients at high risk for renal failure...
  50. doi request reprint Perioperative cardiac biomarkers: the utility and timing
    William Scott Beattie
    Department of Anesthesia, University of Toronto, Toronto, Ontario, Canada
    Curr Opin Crit Care 19:334-41. 2013
    ..This review focuses on the utility of three cardiac biomarkers in perioperative management...
  51. doi request reprint The prevention of chronic postsurgical pain using gabapentin and pregabalin: a combined systematic review and meta-analysis
    Hance Clarke
    Department of Anesthesia and Pain Management, Toronto General Hospital, 200 Elizabeth Street, Eaton North 3 EB 317, Pain Research Unit, Toronto, ON M5G 2C4, Canada
    Anesth Analg 115:428-42. 2012
    ..A search of electronic databases (Medline, Embase, Cochrane Central Register of Controlled Trials, Cochrane Database of Systematic Reviews, IPA, and CINAHL) for relevant English-language trials to June 2011 was conducted...
  52. ncbi request reprint Evaluating surrogate measures of renal dysfunction after cardiac surgery
    Duminda N Wijeysundera
    Department of Anaesthesia, University of Toronto, Ontario, Canada
    Anesth Analg 96:1265-73, table of contents. 2003
    ..Mathematical transformation of DeltaCr(72h) to %DeltaCrCl(72h) results in a normal distribution that is amenable to parametric statistical tests. DeltaCr(72h) and %DeltaCrCl(72h) may be used as surrogate outcomes in future trials...