Natasha Wiebe

Summary

Affiliation: University of Alberta
Country: Canada

Publications

  1. ncbi request reprint A systematic review identifies a lack of standardization in methods for handling missing variance data
    Natasha Wiebe
    Department of Medicine, Division of Nephrology, University of Alberta, Rm 4048, Research Transition Facility, 8308 114 Street, Edmonton, Alberta, Canada T6G 2E1
    J Clin Epidemiol 59:342-53. 2006
  2. doi request reprint Using proteinuria and estimated glomerular filtration rate to classify risk in patients with chronic kidney disease: a cohort study
    Marcello Tonelli
    University of Alberta, Edmonton, Canada
    Ann Intern Med 154:12-21. 2011
  3. pmc Efficacy of statins for primary prevention in people at low cardiovascular risk: a meta-analysis
    Marcello Tonelli
    Department of Medicine, University of Alberta, Edmonton, Alta
    CMAJ 183:E1189-202. 2011
  4. doi request reprint Economic evaluation of erythropoiesis-stimulating agents for anemia related to cancer
    Scott Klarenbach
    Department of Medicine, University of Alberta Edmonton, Alberta, Canada
    Cancer 116:3224-32. 2010
  5. doi request reprint Relation between kidney function, proteinuria, and adverse outcomes
    Brenda R Hemmelgarn
    Department of Medicine, University of Calgary, Calgary, Alberta, Canada
    JAMA 303:423-9. 2010
  6. pmc Association between proximity to the attending nephrologist and mortality among patients receiving hemodialysis
    Marcello Tonelli
    Division of Nephrology and Transplant Immunology, Department of Medicine, University of Alberta, Edmonton, Alta
    CMAJ 177:1039-44. 2007
  7. pmc Adding specialized clinics for remote-dwellers with chronic kidney disease: a cost-utility analysis
    Natasha Wiebe
    Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
    Clin J Am Soc Nephrol 7:24-34. 2012
  8. pmc A novel technique to optimize facility locations of new nephrology services for remote areas
    Bharati Ayyalasomayajula
    Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
    Clin J Am Soc Nephrol 6:2157-64. 2011
  9. doi request reprint Access to kidney transplantation among remote- and rural-dwelling patients with kidney failure in the United States
    Marcello Tonelli
    Department of Medicine, University of Alberta, Edmonton, AB T6B 2B7, Canada
    JAMA 301:1681-90. 2009
  10. ncbi request reprint Dialysate potassium and risk of death in chronic hemodialysis patients
    Ghassan Al-Ghamdi
    Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
    J Nephrol 23:33-40. 2010

Detail Information

Publications47

  1. ncbi request reprint A systematic review identifies a lack of standardization in methods for handling missing variance data
    Natasha Wiebe
    Department of Medicine, Division of Nephrology, University of Alberta, Rm 4048, Research Transition Facility, 8308 114 Street, Edmonton, Alberta, Canada T6G 2E1
    J Clin Epidemiol 59:342-53. 2006
    ..To describe and critically appraise available methods for handling missing variance data in meta-analysis (MA)...
  2. doi request reprint Using proteinuria and estimated glomerular filtration rate to classify risk in patients with chronic kidney disease: a cohort study
    Marcello Tonelli
    University of Alberta, Edmonton, Canada
    Ann Intern Med 154:12-21. 2011
    ..The staging system for chronic kidney disease relies almost exclusively on estimated glomerular filtration rate (eGFR), although proteinuria is also associated with adverse outcomes...
  3. pmc Efficacy of statins for primary prevention in people at low cardiovascular risk: a meta-analysis
    Marcello Tonelli
    Department of Medicine, University of Alberta, Edmonton, Alta
    CMAJ 183:E1189-202. 2011
    ..We did a systematic review of randomized trials to assess the efficacy and harms of statins in these individuals...
  4. doi request reprint Economic evaluation of erythropoiesis-stimulating agents for anemia related to cancer
    Scott Klarenbach
    Department of Medicine, University of Alberta Edmonton, Alberta, Canada
    Cancer 116:3224-32. 2010
    ..Concerns about toxicity have led to more restrictive recommendations for ESA use; however, the incremental costs and benefits of such a strategy are unknown...
  5. doi request reprint Relation between kidney function, proteinuria, and adverse outcomes
    Brenda R Hemmelgarn
    Department of Medicine, University of Calgary, Calgary, Alberta, Canada
    JAMA 303:423-9. 2010
    ..Although proteinuria is also associated with adverse outcomes, it is not used to refine risk estimates of adverse events in this current system...
  6. pmc Association between proximity to the attending nephrologist and mortality among patients receiving hemodialysis
    Marcello Tonelli
    Division of Nephrology and Transplant Immunology, Department of Medicine, University of Alberta, Edmonton, Alta
    CMAJ 177:1039-44. 2007
    ..We investigated whether patients receiving hemodialysis who live farther from their attending nephrologist are more likely to die than those who live closer...
  7. pmc Adding specialized clinics for remote-dwellers with chronic kidney disease: a cost-utility analysis
    Natasha Wiebe
    Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
    Clin J Am Soc Nephrol 7:24-34. 2012
    ..This study aimed to determine whether opening a new clinic in a remote region would be a cost-effective means of improving care for remote-dwellers with CKD...
  8. pmc A novel technique to optimize facility locations of new nephrology services for remote areas
    Bharati Ayyalasomayajula
    Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
    Clin J Am Soc Nephrol 6:2157-64. 2011
    ....
  9. doi request reprint Access to kidney transplantation among remote- and rural-dwelling patients with kidney failure in the United States
    Marcello Tonelli
    Department of Medicine, University of Alberta, Edmonton, AB T6B 2B7, Canada
    JAMA 301:1681-90. 2009
    ..US residents with end-stage renal disease (ESRD) may live far away from the closest transplant center, which could compromise their access to kidney transplantation...
  10. ncbi request reprint Dialysate potassium and risk of death in chronic hemodialysis patients
    Ghassan Al-Ghamdi
    Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
    J Nephrol 23:33-40. 2010
    ..Few data guide the prescription of dialysate potassium (dK) in hemodialysis, which is usually prescribed empirically on the basis of predialysis serum potassium levels...
  11. doi request reprint Clinical decision support to improve blood pressure control in hemodialysis patients: a nonrandomized controlled trial
    Stephanie Thompson
    Division of Nephrology, University of Alberta, Edmonton, Alberta, Canada
    J Nephrol 25:944-53. 2012
    ..Computer-based clinical decision support aims to improve the quality of patient care. The utility of decision support for improving blood pressure control in hemodialysis patients is unknown...
  12. doi request reprint Health care costs of peritoneal dialysis technique failure and dialysis modality switching
    Betty K Chui
    Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
    Am J Kidney Dis 61:104-11. 2013
    ..Although there is a strong economic rationale in favor of peritoneal dialysis (PD) over hemodialysis (HD), the potentially costly effect of PD technique failure is an important consideration in PD program promotion that is unknown...
  13. ncbi request reprint Differences in use of peritoneal dialysis and survival among East Asian, Indo Asian, and white ESRD patients in Canada
    Brenda R Hemmelgarn
    Department of Medicine, Division of Nephrology, University of Calgary, Canada
    Am J Kidney Dis 48:964-71. 2006
    ..Racial differences in health outcomes in general are well documented; however, few studies examined the impact of East Asian and Indo Asian race on choice of dialytic modality and survival among patients with end-stage renal disease (ESRD)...
  14. doi request reprint Quality-of-Care Indicators Among Remote-Dwelling Hemodialysis Patients: A Cohort Study
    Stephanie Thompson
    Division of Nephrology, University of Alberta, Edmonton, Alberta, Canada
    Am J Kidney Dis 62:295-303. 2013
    ..We hypothesized that the higher mortality for hemodialysis patients who live farther from the closest attending nephrologist compared with patients living closer might be due to lower quality of care...
  15. pmc Factors associated with initiation of chronic renal replacement therapy for patients with kidney failure
    Labib I Faruque
    Departments of Medicine, Public Health Sciences, and, Renewable Resources, University of Alberta, Edmonton, Alberta, Canada, Departments of Medicine and, Community Health Sciences, University of Calgary, Calgary, Alberta, Canada
    Clin J Am Soc Nephrol 8:1327-35. 2013
    ..Patients with kidney failure sometimes do not receive chronic renal replacement therapy (RRT), even though this may reduce their life expectancy. This study aimed to identify factors associated with initiation of chronic RRT...
  16. pmc Kidney stones and kidney function loss: a cohort study
    R Todd Alexander
    7 129 Clinical Science Building, University of Alberta, 8440 112 Street, Edmonton, Alberta T6B 2G3, Canada
    BMJ 345:e5287. 2012
    ..To investigate whether the presence of kidney stones increase the risk of end stage renal disease (ESRD) or other adverse renal outcomes...
  17. doi request reprint Relation between alkaline phosphatase, serum phosphate, and all-cause or cardiovascular mortality
    Marcello Tonelli
    Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
    Circulation 120:1784-92. 2009
    ..Higher levels of serum alkaline phosphatase (AlkP) are associated with excess mortality in dialysis patients, but whether AlkP is associated with adverse outcomes among people without kidney failure is unknown...
  18. pmc Benefits and harms of erythropoiesis-stimulating agents for anemia related to cancer: a meta-analysis
    Marcello Tonelli
    Department of Medicine, University of Alberta, Edmonton
    CMAJ 180:E62-71. 2009
    ..However, their safety and effectiveness is controversial. We did a systematic review of the clinical efficacy and harms of these agents in adults with anemia related to cancer or chemotherapy...
  19. pmc Treatment in the pediatric emergency department is evidence based: a retrospective analysis
    Kellie L Waters
    Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada
    BMC Pediatr 6:26. 2006
    ..Further, we wished to ascertain what percentage of evidence for treatment provided in the PED comes from pediatric studies...
  20. pmc Children in reviews: methodological issues in child-relevant evidence syntheses
    Kristie Cramer
    Alberta Research Centre for Child Health Evidence, Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada
    BMC Pediatr 5:38. 2005
    ....
  21. doi request reprint Economic evaluation of continuous renal replacement therapy in acute renal failure
    Scott Klarenbach
    Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
    Int J Technol Assess Health Care 25:331-8. 2009
    ..Controversy exists regarding the optimal method of providing dialysis in critically ill patients with acute renal failure. We sought to determine the cost-effectiveness of treatment strategies...
  22. pmc Overview of the Alberta Kidney Disease Network
    Brenda R Hemmelgarn
    Department of Medicine, University of Calgary, Calgary, Alberta, Canada
    BMC Nephrol 10:30. 2009
    ..The Alberta Kidney Disease Network is a collaborative nephrology research organization based on a central repository of laboratory and administrative data from the Canadian province of Alberta...
  23. pmc Design and implementation of the Canadian Kidney Disease Cohort Study (CKDCS): A prospective observational study of incident hemodialysis patients
    Aminu K Bello
    Department of Medicine, University of Alberta, Edmonton, Canada
    BMC Nephrol 12:10. 2011
    ..This study focuses on delineating potentially reversible determinants of adverse outcomes that occur in patients receiving dialysis for end-stage renal disease (ESRD)...
  24. pmc Trace elements in hemodialysis patients: a systematic review and meta-analysis
    Marcello Tonelli
    Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
    BMC Med 7:25. 2009
    ..We conducted a systematic review to summarize existing literature on trace element status in hemodialysis patients...
  25. pmc Oral rehydration versus intravenous therapy for treating dehydration due to gastroenteritis in children: a meta-analysis of randomised controlled trials
    Steven Bellemare
    Alberta Research Centre for Child Health Evidence, Department of Pediatrics, University of Alberta, 2C3, 00 WMC, Edmonton, Alberta, Canada, T6G 2R7
    BMC Med 2:11. 2004
    ..We conducted a systematic review of randomised controlled trials (RCTs) to compare ORT and intravenous therapy (IVT) for the treatment of dehydration secondary to acute gastroenteritis in children...
  26. doi request reprint Renal replacement therapy in patients with acute renal failure: a systematic review
    Neesh Pannu
    Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
    JAMA 299:793-805. 2008
    ..Acute renal failure requiring dialytic support is associated with a high risk of mortality and substantial morbidity...
  27. pmc A systematic review on the effect of sweeteners on glycemic response and clinically relevant outcomes
    Natasha Wiebe
    Department of Medicine, 13 103 Clinical Sciences Building, University of Alberta, Edmonton, Alberta, T6G 2G3 Canada
    BMC Med 9:123. 2011
    ..The major metabolic complications of obesity and type 2 diabetes may be prevented and managed with dietary modification. The use of sweeteners that provide little or no calories may help to achieve this objective...
  28. ncbi request reprint Heat loss prevention: a systematic review of occlusive skin wrap for premature neonates
    Kristie Cramer
    Complementary and Alternative Research and Education Program, Department of Pediatrics, University of Alberta, Alberta, Canada
    J Perinatol 25:763-9. 2005
    ..To systematically identify and synthesize investigations of the effectiveness of occlusive skin wrap for reducing heat loss in premature infants born at less than 36 weeks gestations...
  29. doi request reprint Glycemic control and the risk of death in 1,484 patients receiving maintenance hemodialysis
    Sabin Shurraw
    Division of Nephrology, University of Alberta, Edmonton, Alberta, Canada
    Am J Kidney Dis 55:875-84. 2010
    ..We aim to determine whether worse glycemic control, measured using serum glucose and hemoglobin A(1c) (HbA(1c)) levels, is independently associated with higher mortality in patients undergoing maintenance hemodialysis...
  30. doi request reprint Meta-analyses of safety data: a comparison of exact versus asymptotic methods
    Ben Vandermeer
    University of Alberta Evidence Based Practice Centre, Alberta Research Centre for Health Evidence
    Stat Methods Med Res 18:421-32. 2009
    ..Asymptotic methods will not always be a good approximation for exact methods in safety meta-analyses. Event rates and number of studies should be closely examined when choosing the statistical method for combining rare event data...
  31. ncbi request reprint A meta-analysis of randomized controlled trials evaluating the efficacy of epinephrine for the treatment of acute viral bronchiolitis
    Lisa Hartling
    Alberta Research Center for Child Health Evidence, Department of Pediatrics, University of Alberta, Edmonton, USA
    Arch Pediatr Adolesc Med 157:957-64. 2003
    ..Controversy exists surrounding the use of bronchodilators for bronchiolitis. Epinephrine hydrochloride is being used with increasing frequency in this group; however, its efficacy has not been systematically reviewed...
  32. pmc Acyclovir for treating varicella in otherwise healthy children and adolescents: a systematic review of randomised controlled trials
    Terry P Klassen
    Alberta Research Center for Child Health Evidence, Department of Pediatrics, University of Alberta, 2C3, 00 WMC, Edmonton, Alberta, T6G 2R7, Canada
    BMC Pediatr 2:9. 2002
    ..We conducted a systematic review of randomised controlled trials that evaluated acyclovir for the treatment of chickenpox in otherwise healthy children...
  33. doi request reprint Basics of systematic reviews and meta-analyses for the nephrologist
    Aminu K Bello
    Division of Nephrology, University of Alberta, Edmonton, AB, Canada
    Nephron Clin Pract 119:c50-60; discussion c61. 2011
    ....
  34. pmc Bariatric surgery: a systematic review of the clinical and economic evidence
    Raj Padwal
    Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
    J Gen Intern Med 26:1183-94. 2011
    ..Use of bariatric surgery for severe obesity has increased dramatically...
  35. ncbi request reprint Statins for improving renal outcomes: a meta-analysis
    Sabrina Sandhu
    Department of Medicine, University of Alberta, Edmonton, Alberta T6B 2B7, Canada
    J Am Soc Nephrol 17:2006-16. 2006
    ..17 to 0.98). Statin therapy seems to reduce proteinuria modestly and results in a small reduction in the rate of kidney function loss, especially in populations with cardiovascular disease...
  36. pmc Residence location and likelihood of kidney transplantation
    Marcello Tonelli
    Division of Nephrology and Transplant Immunology, Department of Medicine, University of Alberta, Edmonton, Alta
    CMAJ 175:478-82. 2006
    ..Within each region we also determined whether distance from the closest transplant centre was associated with the likelihood of transplantation...
  37. ncbi request reprint Meta-analysis: beta-blocker dose, heart rate reduction, and death in patients with heart failure
    Finlay A McAlister
    University of Alberta Hospital, 2F1 21 Walter Mackenzie Health Sciences Centre, 8440 112 Street, Edmonton, Alberta, Canada
    Ann Intern Med 150:784-94. 2009
    ..Guidelines recommend that patients with heart failure receive beta-blockers in doses used in the trials that have proven their efficacy. Although the adverse effects of beta-blockade are dose-related, it is unclear whether the benefits are...
  38. doi request reprint Ultrasound monitoring to detect access stenosis in hemodialysis patients: a systematic review
    Marcello Tonelli
    Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
    Am J Kidney Dis 51:630-40. 2008
    ..Observational studies indicate that routine measurements of access blood flow and use of Doppler ultrasound improve vascular access outcomes in hemodialysis patients, but randomized trials reached conflicting conclusions...
  39. doi request reprint Systematic review and meta-analysis: renal safety of tenofovir disoproxil fumarate in HIV-infected patients
    Ryan D Cooper
    Department of Medicine, University of Alberta, Edmonton, Canada
    Clin Infect Dis 51:496-505. 2010
    ..However, an increasing number of case reports suggest that TDF use may be associated with significant nephrotoxicity. Our objective was to determine the renal safety of TDF-containing ART regimens for HIV-infected individuals...
  40. ncbi request reprint Abstracts of randomized controlled trials presented at the society for pediatric research meeting: an example of publication bias
    Terry P Klassen
    Department of Pediatrics, University of Alberta, 2C3 67 Walter C Mackenzie Centre, Edmonton, Alberta, Canada T6G 2B7
    Arch Pediatr Adolesc Med 156:474-9. 2002
    ..The increased interest in meta-analyses has highlighted the need to identify the totality of evidence when addressing treatment questions...
  41. ncbi request reprint Prophylaxis strategies for contrast-induced nephropathy
    Neesh Pannu
    Department of Medicine, Division of Nephrology, University of Alberta, Edmonton
    JAMA 295:2765-79. 2006
    ..Contrast-induced nephropathy is associated with significant economic and clinical consequences, including prolonged hospitalization, the requirement for dialysis, and an increased risk of death...
  42. ncbi request reprint Chronic kidney disease and mortality risk: a systematic review
    Marcello Tonelli
    Department of Medicine, University of Alberta, Edmonton, Alberta T6B 2B7, Canada
    J Am Soc Nephrol 17:2034-47. 2006
    ..0 in 71% of cohorts. This review supports current guidelines that identify individuals with CKD as being at high risk for cardiovascular mortality. Determining which interventions best offset this risk remains a health priority...
  43. ncbi request reprint Systematic review: cardiac resynchronization in patients with symptomatic heart failure
    Finlay A McAlister
    The University of Alberta and Capital Health Evidence based Practice Center, Edmonton, Alberta, Canada
    Ann Intern Med 141:381-90. 2004
    ..Even with optimal pharmacotherapy, symptomatic heart failure is associated with substantial morbidity and mortality...
  44. ncbi request reprint Practice variation among pediatric emergency departments in the treatment of bronchiolitis
    Amy C Plint
    Department of Pediatrics, University of Ottawa, 401 Smyth Avenue, Ottawa, Ontario, Canada K1H 8L1
    Acad Emerg Med 11:353-60. 2004
    ....
  45. pmc Which resources should be used to identify RCT/CCTs for systematic reviews: a systematic review
    Ellen T Crumley
    HealthInfo and Searching Practice Inc, Edmonton, Canada
    BMC Med Res Methodol 5:24. 2005
    ..This systematic review was conducted in order to assess the value of different resources to identify trials for inclusion in systematic reviews...
  46. ncbi request reprint Systematic review of the clinical efficacy and safety of sevelamer in dialysis patients
    Marcello Tonelli
    Foothills Medical Centre, 1403 29th Street NW, Calgary, Alberta T2N 2T9, Canada
    Nephrol Dial Transplant 22:2856-66. 2007
    ..The relative effectiveness and safety of sevelamer for treatment of hyperphosphataemia in dialysis patients is uncertain, as compared with calcium-based phosphate binders...
  47. ncbi request reprint Tissue adhesives for traumatic lacerations: a systematic review of randomized controlled trials
    Ken J Farion
    Department of Pediatrics, University of Ottawa, Children s Hospital of Eastern Ontario, Ottawa, Canada
    Acad Emerg Med 10:110-8. 2003
    ..To summarize the best available evidence for the effect of tissue adhesives (TAs) in managing traumatic lacerations in children and adults...