G Wells

Summary

Affiliation: University of Ottawa Heart Institute
Country: Canada

Publications

  1. ncbi Canadian-led capacity-building in biostatistics and methodology in cardiovascular and diabetes trials: the CANNeCTIN Biostatistics and Methodological Innovation Working Group
    Lehana Thabane
    Department of Clinical Epidemiology and Biostatistics, McMaster University, 1200 Main Street West, Hamilton, Ontario, L8N 3Z5, Canada
    Trials 12:48. 2011
  2. ncbi Improved delivery of cardiovascular care (IDOCC) through outreach facilitation: study protocol and implementation details of a cluster randomized controlled trial in primary care
    Clare Liddy
    C T Lamont Primary Health Care Research Centre, Elisabeth Bruyere Research Institute, Ottawa, Ontario, Canada
    Implement Sci 6:110. 2011
  3. ncbi Development of a self-administered early inflammatory arthritis detection tool
    Mary J Bell
    Division of Rheumatology, Department of Medicine, University of Toronto, Sunnybrook Health Sciences Centre, Toronto, Canada
    BMC Musculoskelet Disord 11:50. 2010
  4. ncbi Development of AMSTAR: a measurement tool to assess the methodological quality of systematic reviews
    Beverley J Shea
    EMGO Institute, VU University Medical Center, Amsterdam, The Netherlands
    BMC Med Res Methodol 7:10. 2007
  5. ncbi Evaluation of the safety of C-spine clearance by paramedics: design and methodology
    Christian Vaillancourt
    Ottawa Hospital Research Institute, Clinical Epidemiology Program, The Ottawa Hospital Civic Campus, 1053 Carling Avenue, Room F 658, Ottawa, ON, K1Y 4E9, Canada
    BMC Emerg Med 11:1. 2011
  6. ncbi A survey of factors associated with the successful recognition of agonal breathing and cardiac arrest by 9-1-1 call takers: design and methodology
    Christian Vaillancourt
    Ottawa Hospital Research Institute, Clinical Epidemiology Program, The Ottawa Hospital Civic Campus Floor 6, Box 685, 1053 Carling Avenue, Ottawa Ontario, K1Y 4E9, Canada
    BMC Emerg Med 9:14. 2009
  7. ncbi A study to derive a clinical decision rule for triage of emergency department patients with chest pain: design and methodology
    Erik P Hess
    Department of Emergency Medicine, University of Ottawa, Ottawa, Canada
    BMC Emerg Med 8:3. 2008
  8. ncbi A survey of attitudes and factors associated with successful cardiopulmonary resuscitation (CPR) knowledge transfer in an older population most likely to witness cardiac arrest: design and methodology
    Christian Vaillancourt
    Ottawa Health Research Institute, Clinical Epidemiology Program, Ottawa, Canada
    BMC Emerg Med 8:13. 2008
  9. ncbi An evaluation of 9-1-1 calls to assess the effectiveness of dispatch-assisted cardiopulmonary resuscitation (CPR) instructions: design and methodology
    Christian Vaillancourt
    Ottawa Health Research Institute, Clinical Epidemiology Program, Ottawa, Canada
    BMC Emerg Med 8:12. 2008
  10. ncbi Validation of the 28-joint Disease Activity Score (DAS28) and European League Against Rheumatism response criteria based on C-reactive protein against disease progression in patients with rheumatoid arthritis, and comparison with the DAS28 based on erythr
    G Wells
    Department of Epidemiology and Community Medicine, University of Ottawa, Canada
    Ann Rheum Dis 68:954-60. 2009

Collaborators

Detail Information

Publications35

  1. ncbi Canadian-led capacity-building in biostatistics and methodology in cardiovascular and diabetes trials: the CANNeCTIN Biostatistics and Methodological Innovation Working Group
    Lehana Thabane
    Department of Clinical Epidemiology and Biostatistics, McMaster University, 1200 Main Street West, Hamilton, Ontario, L8N 3Z5, Canada
    Trials 12:48. 2011
    ..The ultimate goal is to enhance global health by contributing to efforts to reduce the burden of CVD and DM...
  2. ncbi Improved delivery of cardiovascular care (IDOCC) through outreach facilitation: study protocol and implementation details of a cluster randomized controlled trial in primary care
    Clare Liddy
    C T Lamont Primary Health Care Research Centre, Elisabeth Bruyere Research Institute, Ottawa, Ontario, Canada
    Implement Sci 6:110. 2011
    ....
  3. ncbi Development of a self-administered early inflammatory arthritis detection tool
    Mary J Bell
    Division of Rheumatology, Department of Medicine, University of Toronto, Sunnybrook Health Sciences Centre, Toronto, Canada
    BMC Musculoskelet Disord 11:50. 2010
    ..The objective of this study was to develop a self-administered EIA detection tool for implementation in pre-primary care settings...
  4. ncbi Development of AMSTAR: a measurement tool to assess the methodological quality of systematic reviews
    Beverley J Shea
    EMGO Institute, VU University Medical Center, Amsterdam, The Netherlands
    BMC Med Res Methodol 7:10. 2007
    ..Our objective was to develop an instrument to assess the methodological quality of systematic reviews, building upon previous tools, empirical evidence and expert consensus...
  5. ncbi Evaluation of the safety of C-spine clearance by paramedics: design and methodology
    Christian Vaillancourt
    Ottawa Hospital Research Institute, Clinical Epidemiology Program, The Ottawa Hospital Civic Campus, 1053 Carling Avenue, Room F 658, Ottawa, ON, K1Y 4E9, Canada
    BMC Emerg Med 11:1. 2011
    ..The prolonged immobilization is often unnecessary and adds to the burden of already overtaxed emergency medical services systems and crowded emergency departments...
  6. ncbi A survey of factors associated with the successful recognition of agonal breathing and cardiac arrest by 9-1-1 call takers: design and methodology
    Christian Vaillancourt
    Ottawa Hospital Research Institute, Clinical Epidemiology Program, The Ottawa Hospital Civic Campus Floor 6, Box 685, 1053 Carling Avenue, Ottawa Ontario, K1Y 4E9, Canada
    BMC Emerg Med 9:14. 2009
    ..Improving 9-1-1 call takers' ability to recognize agonal breathing as a sign of cardiac arrest could result in improved bystander cardiopulmonary resuscitation and survival rates for out-of-hospital cardiac arrest victims...
  7. ncbi A study to derive a clinical decision rule for triage of emergency department patients with chest pain: design and methodology
    Erik P Hess
    Department of Emergency Medicine, University of Ottawa, Ottawa, Canada
    BMC Emerg Med 8:3. 2008
    ..Currently no methodologically robust clinical decision rule identifies patients safe for early discharge...
  8. ncbi A survey of attitudes and factors associated with successful cardiopulmonary resuscitation (CPR) knowledge transfer in an older population most likely to witness cardiac arrest: design and methodology
    Christian Vaillancourt
    Ottawa Health Research Institute, Clinical Epidemiology Program, Ottawa, Canada
    BMC Emerg Med 8:13. 2008
    ..However, interest in CPR training appears to decrease with advancing age. Behaviour surrounding CPR training and performance has never been studied using well validated behavioural theories...
  9. ncbi An evaluation of 9-1-1 calls to assess the effectiveness of dispatch-assisted cardiopulmonary resuscitation (CPR) instructions: design and methodology
    Christian Vaillancourt
    Ottawa Health Research Institute, Clinical Epidemiology Program, Ottawa, Canada
    BMC Emerg Med 8:12. 2008
    ..Dispatch-assisted CPR instructions are recommended by the International Guidelines on Emergency Cardiovascular Care, but their ability to improve cardiac arrest survival remains unclear...
  10. ncbi Validation of the 28-joint Disease Activity Score (DAS28) and European League Against Rheumatism response criteria based on C-reactive protein against disease progression in patients with rheumatoid arthritis, and comparison with the DAS28 based on erythr
    G Wells
    Department of Epidemiology and Community Medicine, University of Ottawa, Canada
    Ann Rheum Dis 68:954-60. 2009
    ..To validate and compare the definition of the Disease Activity Score 28 based on C-reactive protein (DAS28 (CRP)) to the definition based on erythrocyte sedimentation rate (ESR)...
  11. ncbi Cardiac resynchronization therapy: a meta-analysis of randomized controlled trials
    George Wells
    University of Ottawa Heart Institute, Ottawa, Ont
    CMAJ 183:421-9. 2011
    ..We performed a meta-analysis including the RAFT trial to determine the effect of cardiac resynchronization therapy with or without an implantable defibrillator on mortality...
  12. ncbi Investigation into the impact of abatacept on sleep quality in patients with rheumatoid arthritis, and the validity of the MOS-Sleep questionnaire Sleep Disturbance Scale
    George Wells
    Department of Epidemiology and Community Medicine, University of Ottawa Heart Institute, 40 Ruskin Street, Ottawa, Ontario K1Y 4W7, Canada
    Ann Rheum Dis 69:1768-73. 2010
    ..To assess the impact of abatacept on sleep quality in patients with rheumatoid arthritis (RA), and the validity of the sleep disturbance scale of the Medical Outcomes Study Sleep Questionnaire (MOS-Sleep)...
  13. ncbi Investigating the validity of the minimal disease activity state for patients with rheumatoid arthritis treated with abatacept
    George A Wells
    Department of Epidemiology and Community Medicine, University of Ottawa, 451 Smyth Road, Ottawa, Ontario KIH 8M5, Canada
    J Rheumatol 36:260-5. 2009
    ..To validate the definitions of minimal disease activity (MDA) in patients with rheumatoid arthritis (RA) and to compare abatacept to control with respect to patients attaining a state of MDA...
  14. ncbi Patient-driven outcomes in rheumatoid arthritis
    George A Wells
    Department of Epidemiology and Community Medicine, University of Ottawa, 451 Smyth Road, Ottawa, Ontario K1H 8M5
    J Rheumatol Suppl 82:33-8. 2009
    ..It is proposed that factors such as Health Assessment Questionnaire scores, fatigue, sleep, and physical and mental function become part of a patient's core set of outcomes when assessing patients with RA...
  15. ncbi Responsiveness of patient reported outcomes including fatigue, sleep quality, activity limitation, and quality of life following treatment with abatacept for rheumatoid arthritis
    G Wells
    Department of Epidemiology and Community Medicine, University of Ottawa, 451 Smyth Rd, Ottawa, Ontario, KIH 8M5 Canada
    Ann Rheum Dis 67:260-5. 2008
    ..To evaluate the responsiveness of patient reported outcomes (PROs), including fatigue, sleep, activity limitation, and quality of life, in patients with rheumatoid arthritis (RA)...
  16. ncbi Validity of quality of life measurement tools--from generic to disease-specific
    George A Wells
    Cardiovascular Research Methods Centre, University of Ottawa Heart Institute, 40 Ruskin Street, Ottawa, Ontario, Canada
    J Rheumatol Suppl 88:2-6. 2011
    ..Several examples of generic and disease-specific instruments commonly used to evaluate HRQOL in patients with immune-mediated inflammatory diseases (IMID) are provided...
  17. ncbi Assessing quality of sleep in patients with rheumatoid arthritis
    George A Wells
    Department of Epidemiology and Community Medicine, University of Ottawa, Ottawa, Ontario, Canada
    J Rheumatol 36:2077-86. 2009
    ..Sleep domains have been reviewed, and several sleep instruments have been identified. These instruments should be considered for use in planned clinical trials of RA patients to assess their applicability...
  18. ncbi Discrimination of changes in osteoporosis outcomes
    A Cranney
    Department of Medicine, Ottawa Hospital, Loeb Research Institute, Ontario, Canada
    J Rheumatol 28:413-21. 2001
    ..Furthermore, these MCID will likely be different for individual patients seen in clinical practice than for individuals in a clinical trial...
  19. ncbi The psychometric properties of patient preferences in osteoporosis
    A Cranney
    Department of Medicine, Ottawa Hospital, Ontario, Canada
    J Rheumatol 28:132-7. 2001
    ..The feeling thermometer and standard gamble appear to be related to different aspects of health related quality of life. Both instruments were sensitive to change over a 2 month period...
  20. ncbi Individualized functional priority approach to the assessment of health related quality of life in rheumatology
    J Clinch
    Clinical Epidemiology Unit, The Ottawa Hospital, and the Faculty of Medicine, University of Ottawa, Ontario, Canada
    J Rheumatol 28:445-51. 2001
    ..Of particular interest are the scoring methods and responsiveness of these questionnaires, both necessary variables for defining minimal clinically important differences...
  21. ncbi Minimal clinically important differences: review of methods
    G Wells
    Department of Epidemiology and Community Medicine, Faculty of Medicine, University of Ottawa, Ontario, Canada
    J Rheumatol 28:406-12. 2001
    ..Development of methods that focus on individuals should be a goal of the future...
  22. ncbi Low level laser therapy for osteoarthritis and rheumatoid arthritis: a metaanalysis
    L Brosseau
    Physiotherapy Program, School of Rehabilitation Sciences, Faculty of Health Sciences, University of Ottawa, Ontario, Canada
    J Rheumatol 27:1961-9. 2000
    ..Low level laser therapy (LLLT) was introduced as an alternative noninvasive treatment for RA and OA about 10 years ago, but its effectiveness is still controversial. We assessed the effectiveness of LLLT in the treatment of RA and OA...
  23. ncbi How Canadian and US rheumatologists treat moderate or aggressive rheumatoid arthritis: a survey
    A Maetzel
    Healthcare Research Division, Arthritis and Immune Disorder Research Centre, Toronto, Ontario, Canada
    J Rheumatol 25:2331-8. 1998
    ..To determine which second line agents Canadian and US rheumatologists use to treat patients with active rheumatoid arthritis (RA)...
  24. ncbi Low disease activity state in rheumatoid arthritis: concepts and derivation of minimal disease activity
    G Wells
    Department of Epidemiology and Community Medicine, University of Ottawa, Ottawa, Ontario, Canada
    Clin Exp Rheumatol 24:S-52-9. 2006
    ....
  25. ncbi A meta-analysis of etidronate for the treatment of postmenopausal osteoporosis
    A Cranney
    Department of Medicine and Clinical Epidemiology, Loeb Research Institute, University of Ottawa, Canada
    Osteoporos Int 12:140-51. 2001
    ..Etidronate increases bone density in the lumbar spine and femoral neck for up to 4 years. The pooled estimates of fracture reduction with etidronate suggest a reduction in vertebral fractures, but no effect on nonvertebral fractures...
  26. ncbi The prevention of chronic NSAID induced upper gastrointestinal toxicity: a Cochrane collaboration metaanalysis of randomized controlled trials
    A Rostom
    Department of Medicine, University of Ottawa, Ontario, Canada
    J Rheumatol 27:2203-14. 2000
    ..To review the effectiveness of common interventions for the prevention of nonsteroidal antiinflammatory drug (NSAID) induced upper gastrointestinal (GI) toxicity...
  27. ncbi Structured exercise improves physical functioning in women with stages I and II breast cancer: results of a randomized controlled trial
    R Segal
    Department of Medical Oncology, Ottawa Regional Cancer Centre, Ottawa, Ontario, Canada
    J Clin Oncol 19:657-65. 2001
    ....
  28. ncbi The impact of risk on preference values: implications for evaluations of postmenopausal osteoporosis therapy
    D Coyle
    Departments of Medicine and Epidemiology and Community Medicine, University of Ottawa, Ottawa, Ontario, Canada
    Value Health 4:385-91. 2001
    ..In this way, we were able to determine the incremental effect of changes in risks of each disease on preference values...
  29. ncbi Establishing reference intervals for DPC's free testosterone radioimmunoassay
    D S Ooi
    Division of Biochemistry, Ottawa Civic Hospital, Ontario, Canada
    Clin Biochem 31:15-21. 1998
    ..To establish reference intervals for serum free testosterone for DPC's Free Testosterone assay...
  30. ncbi Do silicone breast implants cause rheumatologic disorders? A systematic review for a court-appointed national science panel
    P Tugwell
    Centre for Global Health, University of Ottawa, Institute of Population Health, Ontario, Canada
    Arthritis Rheum 44:2477-84. 2001
    ..Therefore, we performed a systematic review of published studies on the association between silicone breast implants and systemic connective tissue disorders...
  31. ncbi A comparison of aprotinin and lysine analogues in high-risk cardiac surgery
    Dean A Fergusson
    Ottawa Health Research Institute, Ottawa, Canada
    N Engl J Med 358:2319-31. 2008
    ..We sought to determine whether aprotinin was superior to either tranexamic acid or aminocaproic acid in decreasing massive postoperative bleeding and other clinically important consequences...
  32. ncbi Reporting disease activity in clinical trials of patients with rheumatoid arthritis: EULAR/ACR collaborative recommendations
    D Aletaha
    Medical University of Vienna, Vienna, Austria
    Arthritis Rheum 59:1371-7. 2008
    ..To make recommendations on how to report disease activity in clinical trials of rheumatoid arthritis (RA) endorsed by the European League Against Rheumatism (EULAR) and the American College of Rheumatology (ACR)...
  33. ncbi Methods of deriving EULAR/ACR recommendations on reporting disease activity in clinical trials of patients with rheumatoid arthritis
    T Karonitsch
    Division of Rheumatology, Medical University of Vienna, Vienna, Austria
    Ann Rheum Dis 67:1365-73. 2008
    ....
  34. ncbi Reporting disease activity in clinical trials of patients with rheumatoid arthritis: EULAR/ACR collaborative recommendations
    D Aletaha
    Division of Rheumatology, Medical University of Vienna, Vienna, Austria
    Ann Rheum Dis 67:1360-4. 2008
    ..To make recommendations on how to report disease activity in clinical trials of rheumatoid arthritis (RA) endorsed by the European League Against Rheumatism (EULAR) and the American College of Rheumatology (ACR)...
  35. ncbi Comparison of the efficacy and safety of finasteride in older versus younger men with benign prostatic hyperplasia
    S A Kaplan
    Columbia Presbyterian Medical Center, New York, New York 10032, USA
    Urology 57:1073-7. 2001
    ..In addition, the safety profile of finasteride in both older and younger men is similar and no drug interactions of clinical importance were observed...