G Wells

Summary

Affiliation: University of Ottawa Heart Institute
Country: Canada

Publications

  1. pmc Alternative Imaging Modalities in Ischemic Heart Failure (AIMI-HF) IMAGE HF Project I-A: study protocol for a randomized controlled trial
    Eileen O'Meara
    Montreal Heart Institute, Montreal, QC, Canada
    Trials 14:218. 2013
  2. pmc The implementation of a community-based aerobic walking program for mild to moderate knee osteoarthritis: a knowledge translation randomized controlled trial: part II: clinical outcomes
    Lucie Brosseau
    Public Health, specialization in Epidemiology, University Research Chair, School of Rehabilitation Sciences, University of Ottawa, Ottawa, Canada
    BMC Public Health 12:1073. 2012
  3. pmc The implementation of a community-based aerobic walking program for mild to moderate knee osteoarthritis (OA): a knowledge translation (KT) randomized controlled trial (RCT): Part I: The Uptake of the Ottawa Panel clinical practice guidelines (CPGs)
    Lucie Brosseau
    School of Rehabilitation Sciences, University of Ottawa, Ottawa, Canada
    BMC Public Health 12:871. 2012
  4. pmc A tutorial on sensitivity analyses in clinical trials: the what, why, when and how
    Lehana Thabane
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON, Canada
    BMC Med Res Methodol 13:92. 2013
  5. pmc Systematic reviews need to consider applicability to disadvantaged populations: inter-rater agreement for a health equity plausibility algorithm
    Vivian Welch
    Clinical Epidemiology Unit, Ottawa Hospital Research Institute, Ottawa Hospital, Ottawa, ON, Canada
    BMC Med Res Methodol 12:187. 2012
  6. pmc Quality of cardiovascular disease care in Ontario, Canada: missed opportunities for prevention - a cross sectional study
    Clare Liddy
    C T Lamont Primary Health Care Research Centre, Bruyère Research Institute, Ottawa, ON, Canada
    BMC Cardiovasc Disord 12:74. 2012
  7. pmc Canadian-led capacity-building in biostatistics and methodology in cardiovascular and diabetes trials: the CANNeCTIN Biostatistics and Methodological Innovation Working Group
    Lehana Thabane
    Department of Clinical Epidemiology and Biostatistics, McMaster University, 1200 Main Street West, Hamilton, Ontario, L8N 3Z5, Canada
    Trials 12:48. 2011
  8. pmc Improved delivery of cardiovascular care (IDOCC) through outreach facilitation: study protocol and implementation details of a cluster randomized controlled trial in primary care
    Clare Liddy
    C T Lamont Primary Health Care Research Centre, Elisabeth Bruyere Research Institute, Ottawa, Ontario, Canada
    Implement Sci 6:110. 2011
  9. pmc Development of a self-administered early inflammatory arthritis detection tool
    Mary J Bell
    Division of Rheumatology, Department of Medicine, University of Toronto, Sunnybrook Health Sciences Centre, Toronto, Canada
    BMC Musculoskelet Disord 11:50. 2010
  10. pmc Development of AMSTAR: a measurement tool to assess the methodological quality of systematic reviews
    Beverley J Shea
    EMGO Institute, VU University Medical Center, Amsterdam, The Netherlands
    BMC Med Res Methodol 7:10. 2007

Collaborators

Detail Information

Publications41

  1. pmc Alternative Imaging Modalities in Ischemic Heart Failure (AIMI-HF) IMAGE HF Project I-A: study protocol for a randomized controlled trial
    Eileen O'Meara
    Montreal Heart Institute, Montreal, QC, Canada
    Trials 14:218. 2013
    ....
  2. pmc The implementation of a community-based aerobic walking program for mild to moderate knee osteoarthritis: a knowledge translation randomized controlled trial: part II: clinical outcomes
    Lucie Brosseau
    Public Health, specialization in Epidemiology, University Research Chair, School of Rehabilitation Sciences, University of Ottawa, Ottawa, Canada
    BMC Public Health 12:1073. 2012
    ..There is therefore a need to improve knowledge translation in order to influence individuals to adopt effective self-management interventions, such as an adapted walking program...
  3. pmc The implementation of a community-based aerobic walking program for mild to moderate knee osteoarthritis (OA): a knowledge translation (KT) randomized controlled trial (RCT): Part I: The Uptake of the Ottawa Panel clinical practice guidelines (CPGs)
    Lucie Brosseau
    School of Rehabilitation Sciences, University of Ottawa, Ottawa, Canada
    BMC Public Health 12:871. 2012
    ....
  4. pmc A tutorial on sensitivity analyses in clinical trials: the what, why, when and how
    Lehana Thabane
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON, Canada
    BMC Med Res Methodol 13:92. 2013
    ..The current paper is the second in a series of tutorial-type manuscripts intended to discuss and clarify aspects related to key methodological issues in the design and analysis of clinical trials...
  5. pmc Systematic reviews need to consider applicability to disadvantaged populations: inter-rater agreement for a health equity plausibility algorithm
    Vivian Welch
    Clinical Epidemiology Unit, Ottawa Hospital Research Institute, Ottawa Hospital, Ottawa, ON, Canada
    BMC Med Res Methodol 12:187. 2012
    ....
  6. pmc Quality of cardiovascular disease care in Ontario, Canada: missed opportunities for prevention - a cross sectional study
    Clare Liddy
    C T Lamont Primary Health Care Research Centre, Bruyère Research Institute, Ottawa, ON, Canada
    BMC Cardiovasc Disord 12:74. 2012
    ..We examined primary care practice adherence to recommended care guidelines associated with the prevention and management of CVD for high risk patients...
  7. pmc Canadian-led capacity-building in biostatistics and methodology in cardiovascular and diabetes trials: the CANNeCTIN Biostatistics and Methodological Innovation Working Group
    Lehana Thabane
    Department of Clinical Epidemiology and Biostatistics, McMaster University, 1200 Main Street West, Hamilton, Ontario, L8N 3Z5, Canada
    Trials 12:48. 2011
    ..The ultimate goal is to enhance global health by contributing to efforts to reduce the burden of CVD and DM...
  8. pmc Improved delivery of cardiovascular care (IDOCC) through outreach facilitation: study protocol and implementation details of a cluster randomized controlled trial in primary care
    Clare Liddy
    C T Lamont Primary Health Care Research Centre, Elisabeth Bruyere Research Institute, Ottawa, Ontario, Canada
    Implement Sci 6:110. 2011
    ....
  9. pmc Development of a self-administered early inflammatory arthritis detection tool
    Mary J Bell
    Division of Rheumatology, Department of Medicine, University of Toronto, Sunnybrook Health Sciences Centre, Toronto, Canada
    BMC Musculoskelet Disord 11:50. 2010
    ..The objective of this study was to develop a self-administered EIA detection tool for implementation in pre-primary care settings...
  10. pmc Development of AMSTAR: a measurement tool to assess the methodological quality of systematic reviews
    Beverley J Shea
    EMGO Institute, VU University Medical Center, Amsterdam, The Netherlands
    BMC Med Res Methodol 7:10. 2007
    ..Our objective was to develop an instrument to assess the methodological quality of systematic reviews, building upon previous tools, empirical evidence and expert consensus...
  11. pmc Evaluation of the safety of C-spine clearance by paramedics: design and methodology
    Christian Vaillancourt
    Ottawa Hospital Research Institute, Clinical Epidemiology Program, The Ottawa Hospital Civic Campus, 1053 Carling Avenue, Room F 658, Ottawa, ON, K1Y 4E9, Canada
    BMC Emerg Med 11:1. 2011
    ..The prolonged immobilization is often unnecessary and adds to the burden of already overtaxed emergency medical services systems and crowded emergency departments...
  12. pmc A survey of factors associated with the successful recognition of agonal breathing and cardiac arrest by 9-1-1 call takers: design and methodology
    Christian Vaillancourt
    Ottawa Hospital Research Institute, Clinical Epidemiology Program, The Ottawa Hospital Civic Campus Floor 6, Box 685, 1053 Carling Avenue, Ottawa Ontario, K1Y 4E9, Canada
    BMC Emerg Med 9:14. 2009
    ..Improving 9-1-1 call takers' ability to recognize agonal breathing as a sign of cardiac arrest could result in improved bystander cardiopulmonary resuscitation and survival rates for out-of-hospital cardiac arrest victims...
  13. pmc A study to derive a clinical decision rule for triage of emergency department patients with chest pain: design and methodology
    Erik P Hess
    Department of Emergency Medicine, University of Ottawa, Ottawa, Canada
    BMC Emerg Med 8:3. 2008
    ..Currently no methodologically robust clinical decision rule identifies patients safe for early discharge...
  14. pmc A survey of attitudes and factors associated with successful cardiopulmonary resuscitation (CPR) knowledge transfer in an older population most likely to witness cardiac arrest: design and methodology
    Christian Vaillancourt
    Ottawa Health Research Institute, Clinical Epidemiology Program, Ottawa, Canada
    BMC Emerg Med 8:13. 2008
    ..However, interest in CPR training appears to decrease with advancing age. Behaviour surrounding CPR training and performance has never been studied using well validated behavioural theories...
  15. pmc An evaluation of 9-1-1 calls to assess the effectiveness of dispatch-assisted cardiopulmonary resuscitation (CPR) instructions: design and methodology
    Christian Vaillancourt
    Ottawa Health Research Institute, Clinical Epidemiology Program, Ottawa, Canada
    BMC Emerg Med 8:12. 2008
    ..Dispatch-assisted CPR instructions are recommended by the International Guidelines on Emergency Cardiovascular Care, but their ability to improve cardiac arrest survival remains unclear...
  16. doi request reprint Assessing quality of sleep in patients with rheumatoid arthritis
    George A Wells
    Department of Epidemiology and Community Medicine, University of Ottawa, Ottawa, Ontario, Canada
    J Rheumatol 36:2077-86. 2009
    ..Sleep domains have been reviewed, and several sleep instruments have been identified. These instruments should be considered for use in planned clinical trials of RA patients to assess their applicability...
  17. doi request reprint Investigation into the impact of abatacept on sleep quality in patients with rheumatoid arthritis, and the validity of the MOS-Sleep questionnaire Sleep Disturbance Scale
    George Wells
    Department of Epidemiology and Community Medicine, University of Ottawa Heart Institute, 40 Ruskin Street, Ottawa, Ontario K1Y 4W7, Canada
    Ann Rheum Dis 69:1768-73. 2010
    ..To assess the impact of abatacept on sleep quality in patients with rheumatoid arthritis (RA), and the validity of the sleep disturbance scale of the Medical Outcomes Study Sleep Questionnaire (MOS-Sleep)...
  18. doi request reprint Investigating the validity of the minimal disease activity state for patients with rheumatoid arthritis treated with abatacept
    George A Wells
    Department of Epidemiology and Community Medicine, University of Ottawa, 451 Smyth Road, Ottawa, Ontario KIH 8M5, Canada
    J Rheumatol 36:260-5. 2009
    ..To validate the definitions of minimal disease activity (MDA) in patients with rheumatoid arthritis (RA) and to compare abatacept to control with respect to patients attaining a state of MDA...
  19. doi request reprint Validity of quality of life measurement tools--from generic to disease-specific
    George A Wells
    Cardiovascular Research Methods Centre, University of Ottawa Heart Institute, 40 Ruskin Street, Ottawa, Ontario, Canada
    J Rheumatol Suppl 88:2-6. 2011
    ..Several examples of generic and disease-specific instruments commonly used to evaluate HRQOL in patients with immune-mediated inflammatory diseases (IMID) are provided...
  20. pmc Cardiac resynchronization therapy: a meta-analysis of randomized controlled trials
    George Wells
    University of Ottawa Heart Institute, Ottawa, Ont
    CMAJ 183:421-9. 2011
    ..We performed a meta-analysis including the RAFT trial to determine the effect of cardiac resynchronization therapy with or without an implantable defibrillator on mortality...
  21. doi request reprint Patient-driven outcomes in rheumatoid arthritis
    George A Wells
    Department of Epidemiology and Community Medicine, University of Ottawa, 451 Smyth Road, Ottawa, Ontario K1H 8M5
    J Rheumatol Suppl 82:33-8. 2009
    ..It is proposed that factors such as Health Assessment Questionnaire scores, fatigue, sleep, and physical and mental function become part of a patient's core set of outcomes when assessing patients with RA...
  22. ncbi request reprint Responsiveness of patient reported outcomes including fatigue, sleep quality, activity limitation, and quality of life following treatment with abatacept for rheumatoid arthritis
    G Wells
    Department of Epidemiology and Community Medicine, University of Ottawa, 451 Smyth Rd, Ottawa, Ontario, KIH 8M5 Canada
    Ann Rheum Dis 67:260-5. 2008
    ..To evaluate the responsiveness of patient reported outcomes (PROs), including fatigue, sleep, activity limitation, and quality of life, in patients with rheumatoid arthritis (RA)...
  23. pmc Validation of the 28-joint Disease Activity Score (DAS28) and European League Against Rheumatism response criteria based on C-reactive protein against disease progression in patients with rheumatoid arthritis, and comparison with the DAS28 based on erythr
    G Wells
    Department of Epidemiology and Community Medicine, University of Ottawa, Canada
    Ann Rheum Dis 68:954-60. 2009
    ..To validate and compare the definition of the Disease Activity Score 28 based on C-reactive protein (DAS28 (CRP)) to the definition based on erythrocyte sedimentation rate (ESR)...
  24. ncbi request reprint Discrimination of changes in osteoporosis outcomes
    A Cranney
    Department of Medicine, Ottawa Hospital, Loeb Research Institute, Ontario, Canada
    J Rheumatol 28:413-21. 2001
    ..Furthermore, these MCID will likely be different for individual patients seen in clinical practice than for individuals in a clinical trial...
  25. ncbi request reprint The psychometric properties of patient preferences in osteoporosis
    A Cranney
    Department of Medicine, Ottawa Hospital, Ontario, Canada
    J Rheumatol 28:132-7. 2001
    ..The feeling thermometer and standard gamble appear to be related to different aspects of health related quality of life. Both instruments were sensitive to change over a 2 month period...
  26. ncbi request reprint Individualized functional priority approach to the assessment of health related quality of life in rheumatology
    J Clinch
    Clinical Epidemiology Unit, The Ottawa Hospital, and the Faculty of Medicine, University of Ottawa, Ontario, Canada
    J Rheumatol 28:445-51. 2001
    ..Of particular interest are the scoring methods and responsiveness of these questionnaires, both necessary variables for defining minimal clinically important differences...
  27. ncbi request reprint Minimal clinically important differences: review of methods
    G Wells
    Department of Epidemiology and Community Medicine, Faculty of Medicine, University of Ottawa, Ontario, Canada
    J Rheumatol 28:406-12. 2001
    ..Development of methods that focus on individuals should be a goal of the future...
  28. ncbi request reprint Low level laser therapy for osteoarthritis and rheumatoid arthritis: a metaanalysis
    L Brosseau
    Physiotherapy Program, School of Rehabilitation Sciences, Faculty of Health Sciences, University of Ottawa, Ontario, Canada
    J Rheumatol 27:1961-9. 2000
    ..Low level laser therapy (LLLT) was introduced as an alternative noninvasive treatment for RA and OA about 10 years ago, but its effectiveness is still controversial. We assessed the effectiveness of LLLT in the treatment of RA and OA...
  29. ncbi request reprint How Canadian and US rheumatologists treat moderate or aggressive rheumatoid arthritis: a survey
    A Maetzel
    Healthcare Research Division, Arthritis and Immune Disorder Research Centre, Toronto, Ontario, Canada
    J Rheumatol 25:2331-8. 1998
    ..To determine which second line agents Canadian and US rheumatologists use to treat patients with active rheumatoid arthritis (RA)...
  30. ncbi request reprint The prevention of chronic NSAID induced upper gastrointestinal toxicity: a Cochrane collaboration metaanalysis of randomized controlled trials
    A Rostom
    Department of Medicine, University of Ottawa, Ontario, Canada
    J Rheumatol 27:2203-14. 2000
    ..To review the effectiveness of common interventions for the prevention of nonsteroidal antiinflammatory drug (NSAID) induced upper gastrointestinal (GI) toxicity...
  31. ncbi request reprint A meta-analysis of etidronate for the treatment of postmenopausal osteoporosis
    A Cranney
    Department of Medicine and Clinical Epidemiology, Loeb Research Institute, University of Ottawa, Canada
    Osteoporos Int 12:140-51. 2001
    ..Etidronate increases bone density in the lumbar spine and femoral neck for up to 4 years. The pooled estimates of fracture reduction with etidronate suggest a reduction in vertebral fractures, but no effect on nonvertebral fractures...
  32. ncbi request reprint Low disease activity state in rheumatoid arthritis: concepts and derivation of minimal disease activity
    G Wells
    Department of Epidemiology and Community Medicine, University of Ottawa, Ottawa, Ontario, Canada
    Clin Exp Rheumatol 24:S-52-9. 2006
    ....
  33. ncbi request reprint Structured exercise improves physical functioning in women with stages I and II breast cancer: results of a randomized controlled trial
    R Segal
    Department of Medical Oncology, Ottawa Regional Cancer Centre, Ottawa, Ontario, Canada
    J Clin Oncol 19:657-65. 2001
    ....
  34. ncbi request reprint The impact of risk on preference values: implications for evaluations of postmenopausal osteoporosis therapy
    D Coyle
    Departments of Medicine and Epidemiology and Community Medicine, University of Ottawa, Ottawa, Ontario, Canada
    Value Health 4:385-91. 2001
    ..In this way, we were able to determine the incremental effect of changes in risks of each disease on preference values...
  35. ncbi request reprint Do silicone breast implants cause rheumatologic disorders? A systematic review for a court-appointed national science panel
    P Tugwell
    Centre for Global Health, University of Ottawa, Institute of Population Health, Ontario, Canada
    Arthritis Rheum 44:2477-84. 2001
    ..Therefore, we performed a systematic review of published studies on the association between silicone breast implants and systemic connective tissue disorders...
  36. ncbi request reprint Establishing reference intervals for DPC's free testosterone radioimmunoassay
    D S Ooi
    Division of Biochemistry, Ottawa Civic Hospital, Ontario, Canada
    Clin Biochem 31:15-21. 1998
    ..To establish reference intervals for serum free testosterone for DPC's Free Testosterone assay...
  37. doi request reprint A comparison of aprotinin and lysine analogues in high-risk cardiac surgery
    Dean A Fergusson
    Ottawa Health Research Institute, Ottawa, Canada
    N Engl J Med 358:2319-31. 2008
    ..We sought to determine whether aprotinin was superior to either tranexamic acid or aminocaproic acid in decreasing massive postoperative bleeding and other clinically important consequences...
  38. doi request reprint Reporting disease activity in clinical trials of patients with rheumatoid arthritis: EULAR/ACR collaborative recommendations
    D Aletaha
    Division of Rheumatology, Medical University of Vienna, Vienna, Austria
    Ann Rheum Dis 67:1360-4. 2008
    ..To make recommendations on how to report disease activity in clinical trials of rheumatoid arthritis (RA) endorsed by the European League Against Rheumatism (EULAR) and the American College of Rheumatology (ACR)...
  39. doi request reprint Methods of deriving EULAR/ACR recommendations on reporting disease activity in clinical trials of patients with rheumatoid arthritis
    T Karonitsch
    Division of Rheumatology, Medical University of Vienna, Vienna, Austria
    Ann Rheum Dis 67:1365-73. 2008
    ....
  40. ncbi request reprint Comparison of the efficacy and safety of finasteride in older versus younger men with benign prostatic hyperplasia
    S A Kaplan
    Columbia Presbyterian Medical Center, New York, New York 10032, USA
    Urology 57:1073-7. 2001
    ..In addition, the safety profile of finasteride in both older and younger men is similar and no drug interactions of clinical importance were observed...
  41. doi request reprint Reporting disease activity in clinical trials of patients with rheumatoid arthritis: EULAR/ACR collaborative recommendations
    D Aletaha
    Medical University of Vienna, Vienna, Austria
    Arthritis Rheum 59:1371-7. 2008
    ..To make recommendations on how to report disease activity in clinical trials of rheumatoid arthritis (RA) endorsed by the European League Against Rheumatism (EULAR) and the American College of Rheumatology (ACR)...