Affiliation: University of Calgary
Illes J, Weiss S, Bains J, Chandler J, Conrod P, De Koninck Y, et al
. A Neuroethics Backbone for the Evolving Canadian Brain Research Strategy. Neuron. 2019;101:370-374 pubmed publisher
Chesnelong C, Restall I, Weiss S. Isolation and Culture of Glioblastoma Brain Tumor Stem Cells. Methods Mol Biol. 2019;1869:11-21 pubmed publisher
..In this chapter, we describe a method to isolate and culture these BTSCs from fresh GBM patient samples. ..
Luchman H, Stechishin O, Nguyen S, Lun X, Cairncross J, Weiss S. Dual mTORC1/2 blockade inhibits glioblastoma brain tumor initiating cells in vitro and in vivo and synergizes with temozolomide to increase orthotopic xenograft survival. Clin Cancer Res. 2014;20:5756-67 pubmed publisher
..AZD8055 was synergistic with the alkylating agent TMZ and significantly prolonged animal survival. These data suggest that dual inhibition of mTORC1/2 may be of benefit in GBM, including the subset of TMZ-resistant GBMs. ..
Zhornitsky S, Johnson T, Metz L, Weiss S, Yong V. Prolactin in combination with interferon-Î² reduces disease severity in an animal model of multiple sclerosis. J Neuroinflammation. 2015;12:55 pubmed publisher
..Histological analyses corroborated the clinical EAE data. These results suggest that prolactin may be beneficial when administered in combination with interferon-Î² in MS. ..
Cusulin C, Chesnelong C, Bose P, Bilenky M, Kopciuk K, Chan J, et al
. Precursor States of Brain Tumor Initiating Cell Lines Are Predictive of SurvivalÂ in Xenografts and Associated with Glioblastoma Subtypes. Stem Cell Reports. 2015;5:1-9 pubmed publisher
..This study proposes a different framework for the study and use of BTICÂ lines and provides precursor biology insights into GBM. ..