H A Weiler

Summary

Affiliation: University of Manitoba
Country: Canada

Publications

  1. ncbi request reprint Dietary conjugated linoleic acid does not adversely affect bone mass in obese fa/fa or lean Zucker rats
    Laura L Burr
    School of Dietetics and Human Nutrition, McGill University, 111 Lakeshore Road, Ste Anne de Bellevue, QC H9X 3V9, Canada
    Exp Biol Med (Maywood) 231:1602-9. 2006
  2. ncbi request reprint Dietary long-chain polyunsaturated fatty acids minimize dexamethasone-induced reductions in arachidonic acid status but not bone mineral content in piglets
    Hope A Weiler
    Department of Foods and Nutrition, University of Manitoba, Winnipeg, Manitoba R3T 2N2, Canada
    Pediatr Res 51:282-9. 2002
  3. ncbi request reprint Growth and bone mineralization of young adults weighing less than 1500 g at birth
    H A Weiler
    Department of Foods and Nutrition, University of Manitoba, Winnipeg, Manitoba, Canada R3T 2N2
    Early Hum Dev 67:101-12. 2002
  4. ncbi request reprint Conjugated linoleic acid reduces parathyroid hormone in health and in polycystic kidney disease in rats
    Hope Weiler
    Department of Human Nutritional Sciences, University of Manitoba, Winnipeg, Manitoba, Canada
    Am J Clin Nutr 79:1186S-1189S. 2004
  5. ncbi request reprint Modulation of essential (n-6):(n-3) fatty acid ratios alters fatty acid status but not bone mass in piglets
    Hope A Weiler
    Department of Human Nutritional Sciences, University of Manitoba, Winnipeg, Manitoba R3T 2N2 Canada
    J Nutr 132:2667-72. 2002
  6. ncbi request reprint Elevated bone turnover in rat polycystic kidney disease is not due to prostaglandin E2
    Hope Weiler
    Department of Human Nutritional Sciences, University of Manitoba, Winnipeg, Manitoba, R3T 2N2, Canada
    Pediatr Nephrol 17:795-9. 2002
  7. ncbi request reprint Percent body fat and bone mass in healthy Canadian females 10 to 19 years of age
    H A Weiler
    Department of Foods and Nutrition, University of Manitoba, Winnipeg, Manitoba, Canada
    Bone 27:203-7. 2000
  8. pmc Vitamin D deficiency and whole-body and femur bone mass relative to weight in healthy newborns
    Hope Weiler
    Department of Human Nutritional Sciences, University of Manitoba, Winnipeg, Man
    CMAJ 172:757-61. 2005
  9. ncbi request reprint Maternal and cord blood long-chain polyunsaturated fatty acids are predictive of bone mass at birth in healthy term-born infants
    Hope Weiler
    Department of Human Nutritional Sciences, University of Manitoba, Winnipeg, Canada
    Pediatr Res 58:1254-8. 2005
  10. ncbi request reprint Modification of polycystic kidney disease and fatty acid status by soy protein diet
    M R Ogborn
    Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, Manitoba, Canada
    Kidney Int 57:159-66. 2000

Collaborators

Detail Information

Publications41

  1. ncbi request reprint Dietary conjugated linoleic acid does not adversely affect bone mass in obese fa/fa or lean Zucker rats
    Laura L Burr
    School of Dietetics and Human Nutrition, McGill University, 111 Lakeshore Road, Ste Anne de Bellevue, QC H9X 3V9, Canada
    Exp Biol Med (Maywood) 231:1602-9. 2006
    ..Thus, commercially available CLA mixtures and single CLA isomers do not affect bone mass in a hyperinsulinemic, obese state...
  2. ncbi request reprint Dietary long-chain polyunsaturated fatty acids minimize dexamethasone-induced reductions in arachidonic acid status but not bone mineral content in piglets
    Hope A Weiler
    Department of Foods and Nutrition, University of Manitoba, Winnipeg, Manitoba R3T 2N2, Canada
    Pediatr Res 51:282-9. 2002
    ..Release of prostaglandin E(2) was elevated only with supplementation of AA. These data indicate that supplemental AA is associated with elevated whole body and femur BMC but that BMC is not enhanced during glucocorticoid treatment...
  3. ncbi request reprint Growth and bone mineralization of young adults weighing less than 1500 g at birth
    H A Weiler
    Department of Foods and Nutrition, University of Manitoba, Winnipeg, Manitoba, Canada R3T 2N2
    Early Hum Dev 67:101-12. 2002
    ..Preterm infants are at risk for suboptimal growth and bone mineralization compared to infants born at term but long-term outcomes into early adulthood are unclear...
  4. ncbi request reprint Conjugated linoleic acid reduces parathyroid hormone in health and in polycystic kidney disease in rats
    Hope Weiler
    Department of Human Nutritional Sciences, University of Manitoba, Winnipeg, Manitoba, Canada
    Am J Clin Nutr 79:1186S-1189S. 2004
    ..Feeding conjugated linoleic acid (CLA) is reported to reduce prostaglandin E(2) synthesis, which is required for parathyroid hormone (PTH) release...
  5. ncbi request reprint Modulation of essential (n-6):(n-3) fatty acid ratios alters fatty acid status but not bone mass in piglets
    Hope A Weiler
    Department of Human Nutritional Sciences, University of Manitoba, Winnipeg, Manitoba R3T 2N2 Canada
    J Nutr 132:2667-72. 2002
    ..The results may be of relevance to the nutritional management of preterm infants whose DHA status is often too low and bone resorption too high...
  6. ncbi request reprint Elevated bone turnover in rat polycystic kidney disease is not due to prostaglandin E2
    Hope Weiler
    Department of Human Nutritional Sciences, University of Manitoba, Winnipeg, Manitoba, R3T 2N2, Canada
    Pediatr Nephrol 17:795-9. 2002
    ..Since PGE2 release is lower in the presence of high bone turnover, the high bone turnover in evolving rat uremia is not likely to be mediated by PGE2...
  7. ncbi request reprint Percent body fat and bone mass in healthy Canadian females 10 to 19 years of age
    H A Weiler
    Department of Foods and Nutrition, University of Manitoba, Winnipeg, Manitoba, Canada
    Bone 27:203-7. 2000
    ..The females in this study appeared to be within reference limits for percent body fat. However, greater amounts of body fat relative to weight could be a marker for lifestyles that do not support attainment of optimal peak bone mass...
  8. pmc Vitamin D deficiency and whole-body and femur bone mass relative to weight in healthy newborns
    Hope Weiler
    Department of Human Nutritional Sciences, University of Manitoba, Winnipeg, Man
    CMAJ 172:757-61. 2005
    ..Vitamin D is required for normal bone growth and mineralization. We sought to determine whether vitamin D deficiency at birth is associated with bone mineral content (BMC) of Canadian infants...
  9. ncbi request reprint Maternal and cord blood long-chain polyunsaturated fatty acids are predictive of bone mass at birth in healthy term-born infants
    Hope Weiler
    Department of Human Nutritional Sciences, University of Manitoba, Winnipeg, Canada
    Pediatr Res 58:1254-8. 2005
    ..Imbalances among the n-6 and n-3 LC PUFA by term gestation are associated with lower bone mass, suggesting that the maternal diet should be balanced in n-6 and n-3 LC PUFA...
  10. ncbi request reprint Modification of polycystic kidney disease and fatty acid status by soy protein diet
    M R Ogborn
    Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, Manitoba, Canada
    Kidney Int 57:159-66. 2000
    ..Modification of polycystic kidney disease and fatty acid status by soy protein diet...
  11. ncbi request reprint Bone density and bone area in Canadian Aboriginal women: the First Nations Bone Health Study
    W D Leslie
    Department of Medicine C5121, University of Manitoba, Winnipeg, Manitoba, Canada
    Osteoporos Int 17:1755-62. 2006
    ..Canadian Aboriginal women are at increased risk of fracture compared with the general population...
  12. ncbi request reprint Gender differences in the modulation of cardiac gene expression by dietary conjugated linoleic acid isomers
    Paramjit S Tappia
    Institute of Cardiovascular Sciences, St Boniface Hospital Research Centre and Department of Human Nutritional Sciences, Faculties of Human Ecology and Medicine, University of Manitoba, 351 Tache Avenue, Winnipeg, MB R2H 2A6, Canada
    Can J Physiol Pharmacol 85:465-75. 2007
    ..The results of this study demonstrate that long-term dietary supplementation can modulate cardiac gene expression and SR function in a gender-related manner and may, in part, contribute to altered cardiac contractility...
  13. doi request reprint Enhanced lumbar spine bone mineral content in piglets fed arachidonic acid and docosahexaenoic acid is modulated by severity of growth restriction
    June Kohut
    Department of Human Nutritional Sciences, University of Manitoba, Winnipeg, Manitoba R3T 2N2, Canada
    Br J Nutr 102:1117-20. 2009
    ..Whether the enhanced lumbar spine BMC is due to enhanced Ca absorption and thus suppression of bone resorption remains to be established...
  14. ncbi request reprint Gender differences in the cardiac response to dietary conjugated linoleic acid isomers
    Paramjit S Tappia
    Institute of Cardiovascular Sciences, St Boniface Hospital Research Centre, University of Manitoba, 351 Tache Avenue, Winnipeg, MB R2H 2A6, Canada
    Can J Physiol Pharmacol 84:257-64. 2006
    ..These results indicate that CLA isomers exert differential effects on heart function and suggest the need for a complete evaluation of the benefits, interactions, and potential side effects of each isomer...
  15. ncbi request reprint Dietary arachidonic acid and docosahexaenoic acid elevate femur calcium and reduce zinc content in piglets
    Rebecca C Mollard
    Department of Human Nutritional Sciences, University of Manitoba, Winnipeg, Manitoba, R3T 2N2, Canada
    Pediatr Res 60:418-22. 2006
    ..Thus, AA:DHA in a ratio of 5:1 does not affect mineral accretion, but AA plus DHA, in amounts similar to the upper limit of human milk, might be detrimental to bone mineralization over time due to lower zinc...
  16. ncbi request reprint Effects of flaxseed derivatives in experimental polycystic kidney disease vary with animal gender
    Malcolm R Ogborn
    Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, Canada
    Lipids 41:1141-9. 2006
    ..Gender-based responses to environmental factors, such as dietary lipid sources and micronutrients, may contribute to gender-based differences in disease progression rates...
  17. ncbi request reprint Bone resorption varies as a function of time of day and quantity of dietary long chain polyunsaturated fatty acids
    Rebecca C Mollard
    Department of Human Nutritional Sciences, University of Manitoba, Winnipeg, Manitoba, R3T 2N2
    J Nutr Biochem 19:482-8. 2008
    ..In regression, plasma AA and DHA were not associated with urinary NTx:creatinine. Dietary AA and DHA at amounts similar to that found in breast milk reduce bone resorption, but do not alter its circadian rhythm...
  18. doi request reprint Parathyroid hormone is predictive of low bone mass in Canadian Aboriginal and White women
    Hope A Weiler
    Human Nutritional Sciences, University of Manitoba, Winnipeg, MB, Canada
    Bone 42:498-504. 2008
    ..In conclusion, PTH is a better predictor of BMD than 25(OH)D in this population of Aboriginal and White women...
  19. ncbi request reprint Leptin predicts bone and fat mass after accounting for the effects of diet and glucocorticoid treatment in piglets
    Hope A Weiler
    Department of Human Nutritional Sciences, University of Manitoba, Winnipeg, Manitoba, Canada R3T 2N2
    Exp Biol Med (Maywood) 227:639-44. 2002
    ..Both human and porcine neonates share similar characteristics with respect to relationships of leptin with fat and bone mass...
  20. doi request reprint Dietary conjugated linoleic acid in the cis-9, trans-11 isoform reduces parathyroid hormone in male, but not female, rats
    Hope A Weiler
    School of Dietetics and Human Nutrition, McGill University, QC, Canada H9X 3V9
    J Nutr Biochem 19:762-9. 2008
    ..Whether such reductions in PTH might be observed in females lacking sex hormones such as ovariectomized rats and also in humans is required to expand health implications of dietary CLA...
  21. doi request reprint Dietary conjugated linoleic acid renal benefits and possible toxicity vary with isomer, dose and gender in rat polycystic kidney disease
    Malcolm R Ogborn
    Department of Pediatrics and Child Health, University of Manitoba, JBRC513 715 McDermot Avenue, Winnipeg, MB, R3C 3P4, Canada
    Lipids 43:783-91. 2008
    ..CLA reduces histologic renal injury in the Han:SPRD-cy rat model probably inversely proportionate to c9,t11 renal content. Possible functional CLA toxicity at high dose in female animals warrants further exploration...
  22. doi request reprint Body composition and bone density in Canadian White and Aboriginal women: the First Nations Bone Health Study
    William D Leslie
    University of Manitoba, Department of Medicine, Canada
    Bone 42:990-5. 2008
    ....
  23. ncbi request reprint Marginal zinc deficiency exacerbates bone lead accumulation and high dietary zinc attenuates lead accumulation at the expense of bone density in growing rats
    Jennifer A Jamieson
    Department of Human Nutritional Sciences, University of Manitoba, Winnipeg, Manitoba, Canada R3T 2N2
    Toxicol Sci 92:286-94. 2006
    ..SZ was protective against bone lead but was detrimental to BMD, suggesting that the optimal level of SZ to reduce lead absorption, while supporting growth and bone development, requires further investigation...
  24. ncbi request reprint Minimal enteral feeding within 3 d of birth in prematurely born infants with birth weight < or = 1200 g improves bone mass by term age
    Hope A Weiler
    Department of Human Nutritional Sciences, University of Manitoba, Winnipeg, Canada
    Am J Clin Nutr 83:155-62. 2006
    ..Evidence-based practice guidelines for aggressive nutritional intervention by using parenteral amino acids (AAs) and minimal enteral feeding (MEF) as early as the first day of life have not been tested for benefits to bone mass...
  25. ncbi request reprint Dietary flax oil reduces renal injury, oxidized LDL content, and tissue n-6/n-3 FA ratio in experimental polycystic kidney disease
    Malcolm R Ogborn
    University of Manitoba, Winnipeg, Manitoba, R3E 3P4 Canada
    Lipids 37:1059-65. 2002
    ..The consumption of FO-based products may prove a more practical way of obtaining health benefit than attempts to increase dietary content of unrefined seed...
  26. ncbi request reprint Dietary arachidonic acid suppresses bone turnover in contrast to low dosage exogenous prostaglandin E(2) that elevates bone formation in the piglet
    Vienna D Lucia
    Department of Human Nutritional Sciences, University of Manitoba, H513 Duff Roblin Building, Winnipeg, Manitoba, Canada R3T 2N2
    Prostaglandins Leukot Essent Fatty Acids 68:407-13. 2003
    ..Both PGE(2) and FA treatments independently lead to elevated femur mineral content, but the combined treatment caused a reduction. Thus the mechanisms by which PGE(2) and FA lead to enhanced bone mass are distinct...
  27. ncbi request reprint Dietary conjugated linoleic acid reduces PGE2 release and interstitial injury in rat polycystic kidney disease
    Malcolm R Ogborn
    Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, Manitoba, Canada
    Kidney Int 64:1214-21. 2003
    ..We studied CLA supplementation in the modification of inflammatory outcomes in the Han:SPRD-cy rat...
  28. ncbi request reprint Dose response of bone mass to dietary arachidonic acid in piglets fed cow milk-based formula
    Janice L Blanaru
    Department of Human Nutritional Sciences, University of Manitoba, Winnipeg, Canada
    Am J Clin Nutr 79:139-47. 2004
    ..The addition of arachidonic acid (AA) and docosahexaenoic acid (DHA) to infant formula was recently approved in North America. In piglets, dietary AA is linked to elevations in bone mass...
  29. ncbi request reprint Sows' milk attenuates dexamethasone-induced reductions in liver docosahexaenoic acid
    Lori Petryk
    Department of Foods and Nutrition, University of Manitoba, Winnipeg, Canada
    Biol Neonate 81:188-95. 2002
    ..A main effect of Dex to reduce AA and DHA was observed in forebrain but not in brainstem. Sows' milk attenuated the Dex-induced reduction in liver DHA but not forebrain AA and DHA or somatic growth...
  30. ncbi request reprint Proximal intestinal absorption of calcium is elevated in proportion to growth rate but not bone mass is small for gestational age piglets
    Rebecca C Mollard
    Department of Human Nutritional Sciences, University of Manitoba, Winnipeg, Manitoba, R3T 2N2, Canada
    J Nutr Biochem 15:149-54. 2004
    ..However, at 21 days of age small for gestational age piglets are similar in size but have lower bone mass compared to appropriate for gestational age piglets...
  31. ncbi request reprint Zinc-deficient rats have more limited bone recovery during repletion than diet-restricted rats
    Heather J Hosea
    Department of Human Nutritional Sciences, University of Manitoba, Winnipeg, MB, R3T 2N2, Canada
    Exp Biol Med (Maywood) 229:303-11. 2004
    ..Zinc deficiency was associated with a greater impairment in bone development than diet restriction, and both deficiencies limited bone recovery during repletion in growing rats...
  32. ncbi request reprint The effect of dietary n-3 long-chain polyunsaturated fatty acids on femur mineral density and biomarkers of bone metabolism in healthy, diabetic and dietary-restricted growing rats
    Kathy H Green
    Department of Human Nutritional Sciences, H513 Duff Roblin Building, University of Manitoba, Winnipeg, Manitoba, Canada
    Prostaglandins Leukot Essent Fatty Acids 71:121-30. 2004
    ..Dietary fish oil promotes bone formation in healthy states, but its effect during insulin deficiency or nutrient restriction is unclear...
  33. ncbi request reprint Dietary soy protein attenuates renal disease progression after 1 and 3 weeks in Han:SPRD-cy weanling rats
    Denise E Fair
    Department of Human Nutritional Sciences, University of Manitoba, Winnipeg, Manitoba, R3T 2N2, Canada
    J Nutr 134:1504-7. 2004
    ..These data demonstrate that dietary soy protein compared with casein delays disease progression in an early stage of chronic kidney disease...
  34. ncbi request reprint Low levels of dietary arachidonic and docosahexaenoic acids improve bone mass in neonatal piglets, but higher levels provide no benefit
    Rebecca C Mollard
    Department of Human Nutritional Sciences, University of Manitoba, Winnipeg, Manitoba, R3T 2N2 Canada
    J Nutr 135:505-12. 2005
    ..0:0.4 g AA:DHA/100 g of fat (P = 0.039). The diets did not affect the other biochemical variables measured. Low levels of dietary AA:DHA (0.5:0.1 g/100 g of fat) elevate bone mass, but higher amounts are not beneficial...
  35. ncbi request reprint (n-3) fatty acids reduce the release of prostaglandin E2 from bone but do not affect bone mass in obese (fa/fa) and lean Zucker rats
    Rebecca C Mollard
    Department of Human Nutritional Sciences, University of Manitoba, Winnipeg, Manitoba, R3T 2N2 Canada
    J Nutr 135:499-504. 2005
    ..Whether reduced PGE(2) will support optimal peak bone mass during childhood and conserve bone mass with aging warrants investigation...
  36. ncbi request reprint Polyunsaturated fatty acids and bone mass
    Hope A Weiler
    Am J Clin Nutr 80:1085-6; author reply 1086-7. 2004
  37. doi request reprint Dietary long-chain inulin reduces abdominal fat but has no effect on bone density in growing female rats
    Jennifer A Jamieson
    Department of Human Nutritional Sciences, University of Manitoba, Winnipeg, MB R3T 2N2, Canada
    Br J Nutr 100:451-9. 2008
    ..In summary, LC-inulin lowered body fat mass, without consequence to bone density in growing female rats...
  38. ncbi request reprint Canadian Aboriginal women have a higher prevalence of vitamin D deficiency than non-Aboriginal women despite similar dietary vitamin D intakes
    Hope A Weiler
    Human Nutritional Sciences, Faculty of Medicine, University of Manitoba, Winnipeg, R3T 2N2 MB, Canada
    J Nutr 137:461-5. 2007
    ..5 nmol/L. The high prevalence of vitamin D deficiency among Aboriginal women, combined with lower dietary intake of calcium, especially in older women, likely contributes to the higher incidence of fracture in this population...
  39. ncbi request reprint Summary of evidence-based review on vitamin D efficacy and safety in relation to bone health
    Ann Cranney
    Clinical Epidemiology Program, Ottawa Health Research Institute, Ottawa Hospital, and The University of Ottawa Evidence based Practice Center, Ottawa, Ontario, Canada
    Am J Clin Nutr 88:513S-519S. 2008
    ..We found fair evidence that adults tolerated vitamin D at doses above current dietary reference intake levels, but we had no data on the association between long-term harms and higher doses of vitamin D...
  40. ncbi request reprint Bone mass in First Nations, Asian and white newborn infants
    Hope A Weiler
    School of Dietetics and Human Nutrition, McGill University, Ste Anne de Bellevue, QC H9X 3V9, Canada
    Growth Dev Aging 71:35-43. 2008
    ..These data suggest that white and First Nations newborn infants have comparable bone mass. Asian infants have lower spine bone mass which is more than a factor of body size and independent of vitamin D status at birth...
  41. ncbi request reprint Ethnic differences in adiposity and body composition: the First Nations bone health study
    William D Leslie
    Faculty of Medicine C5121, 409 Tache Ave, University of Manitoba, Winnipeg, MB R2H 2A6, Canada
    Appl Physiol Nutr Metab 32:1065-72. 2007
    ..First Nations women had a preferential increase in trunk fat and this may contribute to high reported rates of diabetes, metabolic syndrome, and cardiovascular events...