T H Watts
Affiliation: University of Toronto
Zhou A, Batista N, Watts T. 4-1BB Regulates Effector CD8 T Cell Accumulation in the Lung Tissue through a TRAF1-, mTOR-, and Antigen-Dependent Mechanism to Enhance Tissue-Resident Memory T Cell Formation during Respiratory Influenza Infection. J Immunol. 2019;202:2482-2492 pubmed publisher
..Taken together, these data point to an important role for 4-1BB, TRAF1, and mTOR in the persistence of CD8 effector T cells in the lung parenchyma, thereby allowing the transition to Trm. ..
Girard M, Watts T. Fc-Engineered Anti-4-1BB Antibodies Pack a One-Two Punch. Immunity. 2018;49:791-793 pubmed publisher
..2018) reveal the importance of antibody Fc region, Fc receptor availability, and sequence of administration for optimal cancer therapy with antibodies targeting the co-stimulatory receptor 4-1BB. ..
Chu K, Batista N, Wang K, Zhou A, Watts T. GITRL on inflammatory antigen presenting cells in the lung parenchyma provides signal 4 for T-cell accumulation and tissue-resident memory T-cell formation. Mucosal Immunol. 2019;12:363-377 pubmed publisher
..Thus, GITR signaling within the lung tissue critically regulates effector and tissue-resident memory T-cell accumulation. ..
Clouthier D, Watts T. TNFRs and Control of Chronic LCMV Infection: Implications for Therapy. Trends Immunol. 2015;36:697-708 pubmed publisher
..We discuss preclinical models of TNF/TNFR family-targeted immunotherapy of chronic LCMV infection and evaluate which TNFRs present the most promising targets for immune intervention. ..
Watts T, Lin G, Wang C, McPherson A, Snell L, Sabbagh L. Role of 4-1BBL and TRAF1 in the CD8 T cell response to influenza virus and HIV. Adv Exp Med Biol. 2011;691:177-86 pubmed publisher
Clouthier D, Zhou A, Watts T. Anti-GITR agonist therapy intrinsically enhances CD8 T cell responses to chronic lymphocytic choriomeningitis virus (LCMV), thereby circumventing LCMV-induced downregulation of costimulatory GITR ligand on APC. J Immunol. 2014;193:5033-43 pubmed publisher
..These studies identify GITR as a promising therapeutic target for chronic infection. ..
Mbanwi A, Lin G, Wang K, Watts T. Constitutive interaction between 4-1BB and 4-1BBL on murine LPS-activated bone marrow dendritic cells masks detection of 4-1BBL by TKS-1 but not 19H3 antibody. J Immunol Methods. 2017;450:81-89 pubmed publisher
..These data suggest that 19H3 is the preferable antibody to use to detect 4-1BBL in the presence of its receptor. ..
Chang Y, Wang K, Chu K, Clouthier D, Tran A, Torres Perez M, et al
. Dichotomous Expression of TNF Superfamily Ligands on Antigen-Presenting Cells Controls Post-priming Anti-viral CD4+ T Cell Immunity. Immunity. 2017;47:943-958.e9 pubmed publisher
..Thus IFN-I (signal 3) induced a post-priming checkpoint (signal 4) for CD4+ TÂ cell accumulation, revealing a division of labor between cDCs and monocyte-derived APCs in regulating T cell expansion. ..
Wang C, Edilova M, Wagar L, Mujib S, Singer M, Bernard N, et al
. Effect of IL-7 Therapy on Phospho-Ribosomal Protein S6 and TRAF1 Expression in HIV-Specific CD8 T Cells in Patients Receiving Antiretroviral Therapy. J Immunol. 2018;200:558-564 pubmed publisher
..Thus, IL-7 therapy in antiretroviral therapy-treated patients induces sustained changes in the number and phenotype of HIV-specific T cells. ..