Matthew J Watt

Summary

Affiliation: University of Guelph
Country: Canada

Publications

  1. pmc Intramuscular triacylglycerol, glycogen and acetyl group metabolism during 4 h of moderate exercise in man
    Matthew J Watt
    Department of Human Biology and Nutritional Sciences, University of Guelph, Ontario N1G 2W1
    J Physiol 541:969-78. 2002
  2. pmc Effects of dynamic exercise intensity on the activation of hormone-sensitive lipase in human skeletal muscle
    Matthew J Watt
    Department of Human Biology and Nutritional Sciences, University of Guelph, Guelph, Ontario N1G 2W1, Canada
    J Physiol 547:301-8. 2003
  3. pmc Carbohydrate ingestion reduces skeletal muscle acetylcarnitine availability but has no effect on substrate phosphorylation at the onset of exercise in man
    Matthew J Watt
    Department of Human Biology and Nutritional Sciences, University of Guelph, Ontario N1G 2W1, Canada
    J Physiol 544:949-56. 2002
  4. ncbi Intramuscular triacylglycerol utilization in human skeletal muscle during exercise: is there a controversy?
    Matthew J Watt
    Department of Human Biology and Nutritional Sciences, University of Guelph, Guelph, Ontario N1G 2W1, Canada
    J Appl Physiol 93:1185-95. 2002
  5. ncbi Adrenergic regulation of HSL serine phosphorylation and activity in human skeletal muscle during the onset of exercise
    Jason L Talanian
    Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada N1G 2W1
    Am J Physiol Regul Integr Comp Physiol 291:R1094-9. 2006
  6. pmc Effects of plasma adrenaline on hormone-sensitive lipase at rest and during moderate exercise in human skeletal muscle
    Matthew J Watt
    Department of Human Biology and Nutritional Sciences, University of Guelph, Guelph, Ontario N1G 2W1, Canada
    J Physiol 550:325-32. 2003
  7. ncbi Hormone-sensitive lipase activity and fatty acyl-CoA content in human skeletal muscle during prolonged exercise
    Matthew J Watt
    Department of Human Biology and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada
    J Appl Physiol 95:314-21. 2003
  8. ncbi Effects of hyperoxia on skeletal muscle carbohydrate metabolism during transient and steady-state exercise
    Trent Stellingwerff
    Dept of Human Biology and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada N1G 2W1
    J Appl Physiol 98:250-6. 2005
  9. ncbi Rapid upregulation of pyruvate dehydrogenase kinase activity in human skeletal muscle during prolonged exercise
    Matthew J Watt
    Department of Human Biology and Nutritional Sciences, University of Guelph, Guelph, Ontario N1G 2W1
    J Appl Physiol 97:1261-7. 2004
  10. ncbi Effects of reduced free fatty acid availability on hormone-sensitive lipase activity in human skeletal muscle during aerobic exercise
    Marcus O'Neill
    Department of Human Biology and Nutritional Sciences, University of Guelph, Guelph, ON, Canada N1G 2W1
    J Appl Physiol 97:1938-45. 2004

Collaborators

Detail Information

Publications47

  1. pmc Intramuscular triacylglycerol, glycogen and acetyl group metabolism during 4 h of moderate exercise in man
    Matthew J Watt
    Department of Human Biology and Nutritional Sciences, University of Guelph, Ontario N1G 2W1
    J Physiol 541:969-78. 2002
    ..Although the factor underlying the PDHa decrease was not apparent, reduced pyruvate provision secondary to diminished glycolytic flux is the most likely mechanism...
  2. pmc Effects of dynamic exercise intensity on the activation of hormone-sensitive lipase in human skeletal muscle
    Matthew J Watt
    Department of Human Biology and Nutritional Sciences, University of Guelph, Guelph, Ontario N1G 2W1, Canada
    J Physiol 547:301-8. 2003
    ....
  3. pmc Carbohydrate ingestion reduces skeletal muscle acetylcarnitine availability but has no effect on substrate phosphorylation at the onset of exercise in man
    Matthew J Watt
    Department of Human Biology and Nutritional Sciences, University of Guelph, Ontario N1G 2W1, Canada
    J Physiol 544:949-56. 2002
    ..These data suggest that acetylcarnitine availability is unlikely to be the site of metabolic inertia during the transition from rest to steady-state moderate intensity exercise...
  4. ncbi Intramuscular triacylglycerol utilization in human skeletal muscle during exercise: is there a controversy?
    Matthew J Watt
    Department of Human Biology and Nutritional Sciences, University of Guelph, Guelph, Ontario N1G 2W1, Canada
    J Appl Physiol 93:1185-95. 2002
    ..Therefore, it is our contention that the muscle biopsy, isotope tracer, and (1)H-MRS techniques report significant and energetically important oxidation of free fatty acids derived from IMTGs during prolonged moderate exercise...
  5. ncbi Adrenergic regulation of HSL serine phosphorylation and activity in human skeletal muscle during the onset of exercise
    Jason L Talanian
    Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada N1G 2W1
    Am J Physiol Regul Integr Comp Physiol 291:R1094-9. 2006
    ..This adrenergic stimulation contributes to the increase in HSL activity that occurs in human skeletal muscle in the first minute of exercise at 65% and 90% VO2 peak...
  6. pmc Effects of plasma adrenaline on hormone-sensitive lipase at rest and during moderate exercise in human skeletal muscle
    Matthew J Watt
    Department of Human Biology and Nutritional Sciences, University of Guelph, Guelph, Ontario N1G 2W1, Canada
    J Physiol 550:325-32. 2003
    ..The results also demonstrate that increased ERK 1/2 phosphorylation coincides with elevated HSL activity, indicating that ERK 1/2 may mediate the contraction-induced increase in HSL activity early in exercise...
  7. ncbi Hormone-sensitive lipase activity and fatty acyl-CoA content in human skeletal muscle during prolonged exercise
    Matthew J Watt
    Department of Human Biology and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada
    J Appl Physiol 95:314-21. 2003
    ..The accumulation of LCFA CoA in the 2nd h of exercise may also have reduced the flux through HSL and accounted for the reduction in IMTG utilization previously observed late in prolonged exercise...
  8. ncbi Effects of hyperoxia on skeletal muscle carbohydrate metabolism during transient and steady-state exercise
    Trent Stellingwerff
    Dept of Human Biology and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada N1G 2W1
    J Appl Physiol 98:250-6. 2005
    ..The mechanism responsible for the decreased muscle glycogenolysis during hyperoxia in the present study is not clear...
  9. ncbi Rapid upregulation of pyruvate dehydrogenase kinase activity in human skeletal muscle during prolonged exercise
    Matthew J Watt
    Department of Human Biology and Nutritional Sciences, University of Guelph, Guelph, Ontario N1G 2W1
    J Appl Physiol 97:1261-7. 2004
    ..The increased PDK activity was independent of changes in intra-mitochondrial effectors, and PDK-2 and PDK-4 protein content, suggesting that it was caused by a change in the specific activity of the existing kinases...
  10. ncbi Effects of reduced free fatty acid availability on hormone-sensitive lipase activity in human skeletal muscle during aerobic exercise
    Marcus O'Neill
    Department of Human Biology and Nutritional Sciences, University of Guelph, Guelph, ON, Canada N1G 2W1
    J Appl Physiol 97:1938-45. 2004
    ..In conclusion, reduced plasma FFA availability accompanied by increased epinephrine concentration did not further activate HSL beyond exercise alone...
  11. ncbi Decreased PDH activation and glycogenolysis during exercise following fat adaptation with carbohydrate restoration
    Trent Stellingwerff
    Department of Human Biology and Nutritional Sciences, University of Guelph, Ontario, Canada
    Am J Physiol Endocrinol Metab 290:E380-8. 2006
    ....
  12. ncbi Regulation and role of hormone-sensitive lipase activity in human skeletal muscle
    Matthew J Watt
    Department of Human Biology and Nutritional Sciences, University of Guelph, Ontario, Canada
    Proc Nutr Soc 63:315-22. 2004
    ..For example, it must be remembered that the actual flux (IMTG degradation) through HSL may be allosterically inhibited during prolonged exercise as a result of the accumulation of long-chain fatty acyl-CoA...
  13. ncbi Effects of reduced free fatty acid availability on skeletal muscle PDH activation during aerobic exercise. Pyruvate dehydrogenase
    Trent Stellingwerff
    Department of Human Biology and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada
    Am J Physiol Endocrinol Metab 284:E589-96. 2003
    ..The increased activation of PDH was not explained by changes in muscle pyruvate or the ATP/ADP ratio but may be related to a decrease in the NADH/NAD(+) ratio or an epinephrine-induced increase in calcium concentration...
  14. ncbi Pyruvate dehydrogenase activation and kinase expression in human skeletal muscle during fasting
    Lawrence L Spriet
    Department of Human Biology and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada N1G 2W1
    J Appl Physiol 96:2082-7. 2004
    ..The changes in PDK-4 expression and PDH activity did not coincide with increases in the transcriptional activators PPAR-alpha and FKHR...
  15. ncbi Reduced glycogen availability is associated with increased AMPKalpha2 activity, nuclear AMPKalpha2 protein abundance, and GLUT4 mRNA expression in contracting human skeletal muscle
    Gregory R Steinberg
    Vincent s Institute and Department of Medicine, University of Melbourne, Fitzroy, Victoria, Australia
    Appl Physiol Nutr Metab 31:302-12. 2006
    ..We suggest that increased activation of AMPK alpha2 under conditions of low muscle glycogen enhances AMPK alpha2 nuclear translocation and increases GLUT4 mRNA expression in response to exercise in human skeletal muscle...
  16. ncbi Apoptosis in skeletal muscle myotubes is induced by ceramides and is positively related to insulin resistance
    Sarah M Turpin
    St Vincent s Institute of Medical Research, Fitzroy, Victoria 3064, Australia
    Am J Physiol Endocrinol Metab 291:E1341-50. 2006
    ..We conclude that lipoapoptosis occurs in skeletal muscle myotubes, at least partially via de novo ceramide accumulation, and that inhibiting downstream apoptotic signaling improves glucose uptake in vitro...
  17. ncbi CNTF reverses obesity-induced insulin resistance by activating skeletal muscle AMPK
    Matthew J Watt
    Cellular and Molecular Metabolism Laboratory, School of Medical Sciences, Royal Melbourne Institute of Technology, PO Box 71, Bundoora, 3083, Australia
    Nat Med 12:541-8. 2006
    ....
  18. pmc Fatty acids stimulate AMP-activated protein kinase and enhance fatty acid oxidation in L6 myotubes
    Matthew J Watt
    Cellular and Molecular Metabolism Laboratory, School of Medical Sciences, RMIT University, Victoria, Australia
    J Physiol 574:139-47. 2006
    ....
  19. ncbi Thiazolidinediones enhance skeletal muscle triacylglycerol synthesis while protecting against fatty acid-induced inflammation and insulin resistance
    Mark K Todd
    Department of Kinesiology, University of Southern California, Los Angeles, California, USA
    Am J Physiol Endocrinol Metab 292:E485-93. 2007
    ..Despite this, TZDs suppress the inflammatory response to dietary lipid overload, and it is this mechanism that correlates strongly with insulin sensitivity...
  20. ncbi Interleukin-6 increases insulin-stimulated glucose disposal in humans and glucose uptake and fatty acid oxidation in vitro via AMP-activated protein kinase
    Andrew L Carey
    Cellular and Molecular Metabolism Laboratory, School of Medical Sciences, Royal Melbourne Institute of Technology RMIT University, Australia
    Diabetes 55:2688-97. 2006
    ..Our results demonstrate that acute IL-6 treatment enhances insulin-stimulated glucose disposal in humans in vivo, while the effects of IL-6 on glucose and fatty acid metabolism in vitro appear to be mediated by AMPK...
  21. ncbi Dysregulation of muscle lipid metabolism in rats selectively bred for low aerobic running capacity
    Fiona J Spargo
    Exercise Metabolism Group, School of Medical Sciences, Australia
    Am J Physiol Endocrinol Metab 292:E1631-6. 2007
    ..In conclusion, rats with low intrinsic aerobic capacity demonstrate abnormalities in lipid-handling capacity. These disruptions may, in part, be responsible for the increased risk of metabolic disorders observed in this phenotype...
  22. ncbi Dissociation of hepatic steatosis and insulin resistance in mice overexpressing DGAT in the liver
    Mara Monetti
    Gladstone Institute of Cardiovascular Disease, 1650 Owens Street, San Francisco, CA 94158, USA
    Cell Metab 6:69-78. 2007
    ..Our results indicate that DGAT-mediated lipid accumulation in the liver is insufficient to cause insulin resistance and show that hepatic steatosis can occur independently of insulin resistance...
  23. ncbi Increased lipid accumulation and insulin resistance in transgenic mice expressing DGAT2 in glycolytic (type II) muscle
    Malin C Levin
    Gladstone Institute of Cardiovascular Disease, 1650 Owens St, San Francisco, CA 94158, USA
    Am J Physiol Endocrinol Metab 293:E1772-81. 2007
    ..We conclude that DGAT2-mediated lipid deposition specifically in glycolytic muscle promotes insulin resistance in this tissue and may contribute to the development of diabetes...
  24. doi Adipose triglyceride lipase regulation of skeletal muscle lipid metabolism and insulin responsiveness
    Matthew J Watt
    St Vincent s Institute of Medical Research, Department of Medicine, University of Melbourne, Fitzroy, Victoria 3065, Australia
    Mol Endocrinol 22:1200-12. 2008
    ....
  25. pmc HSP72 protects against obesity-induced insulin resistance
    Jason Chung
    Cellular and Molecular Metabolism Laboratory, Clinical Physiology, and Human Vascular Biology, Baker Heart Research Institute, Prahran, P O Box 6492, Victoria 8008, Australia
    Proc Natl Acad Sci U S A 105:1739-44. 2008
    ..These findings identify an essential role for HSP72 in blocking inflammation and preventing insulin resistance in the context of genetic obesity or high-fat feeding...
  26. doi High rates of muscle glycogen resynthesis after exhaustive exercise when carbohydrate is coingested with caffeine
    David J Pedersen
    School of Medical Sciences, RMIT University, Bundoora 3083, Victoria, Australia
    J Appl Physiol 105:7-13. 2008
    ..We provide the first evidence that in trained subjects coingestion of large amounts of Caff (8 mg/kg BM) with CHO has an additive effect on rates of postexercise muscle glycogen accumulation compared with consumption of CHO alone...
  27. ncbi Ciliary neurotrophic factor prevents acute lipid-induced insulin resistance by attenuating ceramide accumulation and phosphorylation of c-Jun N-terminal kinase in peripheral tissues
    Matthew J Watt
    Cellular and Molecular Metabolism Laboratory, School of Medical Sciences, RMIT University, Bundoora, Victoria, Australia
    Endocrinology 147:2077-85. 2006
    ..These data support the use of CNTF as a potential therapeutic means to combat lipid-induced insulin resistance...
  28. ncbi Saturated, but not n-6 polyunsaturated, fatty acids induce insulin resistance: role of intramuscular accumulation of lipid metabolites
    Jong Sam Lee
    Department of Physical Therapy, College of Medicine, Eulji University, Young Du Dong, Jung Gu, Daejeon, Seoul, South Korea
    J Appl Physiol 100:1467-74. 2006
    ..Diets rich in n-6 PUFA appear to prevent insulin resistance by directing fat into TAG, rather than other lipid metabolites...
  29. ncbi Effect of epinephrine on glucose disposal during exercise in humans: role of muscle glycogen
    Matthew J Watt
    Exercise, Muscle and Metabolism Unit, School of Health Sciences, Deakin University, Burwood, Victoria 3125, Australia
    Am J Physiol Endocrinol Metab 283:E578-83. 2002
    ....
  30. ncbi Hormone-sensitive lipase activity and triacylglycerol hydrolysis are decreased in rat soleus muscle by cyclopiazonic acid
    Matthew J Watt
    School of Medical Sciences, Royal Melbourne Institute of Technology, PO Box 71, Bundoora, Victoria 3083, Australia
    Am J Physiol Endocrinol Metab 285:E412-9. 2003
    ..It is possible that more powerful signals or a higher [Ca2+] may override the lipid-storage effect of the CPA-mediated effects during muscular contractions...
  31. ncbi Glucose ingestion blunts hormone-sensitive lipase activity in contracting human skeletal muscle
    Matthew J Watt
    Skeletal Muscle Research Laboratory, School of Medical Sciences, Royal Melbourne Institute of Technology University, PO Box 71, Bundoora 3083, Victoria, Australia
    Am J Physiol Endocrinol Metab 286:E144-50. 2004
    ..16 +/- 0.59, GLU, 1.37 +/- 0.37 mmol/min) in GLU compared with CON. These results demonstrate that circulating insulin and epinephrine play a role in HSLa in contracting skeletal muscle...
  32. ncbi Regulation of glucose kinetics during intense exercise in humans: effects of alpha- and beta-adrenergic blockade
    Kirsten F Howlett
    Exercise, Muscle and Metabolism Unit, School of Health Sciences, Deakin University, Burwood, Australia
    Metabolism 52:1615-20. 2003
    ..05) in BLK. These findings demonstrate that adrenergic blockade during intense exercise results in a blunted plasma glucose response that is due to enhanced glucose uptake, with no significant change in glucose production...
  33. ncbi Reduced plasma FFA availability increases net triacylglycerol degradation, but not GPAT or HSL activity, in human skeletal muscle
    Matthew J Watt
    Skeletal Muscle Research Laboratory, School of Medical Sciences, RMIT Univ, PO Box 71, Bundoora 3083, Victoria, Australia
    Am J Physiol Endocrinol Metab 287:E120-7. 2004
    ..These changes in IMTG degradation appear to disassociate, however, from the activity of the key enzymes responsible for synthesis and degradation of this substrate...
  34. ncbi Cytokine gene expression in human skeletal muscle during concentric contraction: evidence that IL-8, like IL-6, is influenced by glycogen availability
    M H Stanley Chan
    Skeletal Muscle Research Laboratory, School of Medical Sciences, RMIT University, Bundoora, Victoria 3083, Australia
    Am J Physiol Regul Integr Comp Physiol 287:R322-7. 2004
    ..Furthermore, the mRNA abundance of IL-6 and IL-8 appears to be influenced by glycogen availability in the contracting muscle...
  35. ncbi Suppressing lipolysis increases interleukin-6 at rest and during prolonged moderate-intensity exercise in humans
    Anna G Holmes
    Skeletal Muscle Research Laboratory, School of Medical Sciences, RMIT University, P O Box 71, Bundoora 3083, Victoria, Australia
    J Appl Physiol 97:689-96. 2004
    ..98 pg/ml; NA, 19.23 +/- 2.50 pg/ml; P < 0.05) during exercise. In conclusion, these data demonstrate that circulating IL-6 is markedly elevated at rest and during prolonged moderate-intensity exercise when lipolysis is suppressed...
  36. ncbi Beta-adrenergic stimulation of skeletal muscle HSL can be overridden by AMPK signaling
    Matthew J Watt
    Skeletal Muscle Research Laboratory, School of Medical Sciences, Royal Melbourne Institute of Technology, Bundoora, Victoria, Australia
    FASEB J 18:1445-6. 2004
    ..However, the increased IMTG degradation in LG suggests factors other than HSL activity are important for IMTG degradation...
  37. ncbi PGC-1alpha gene expression is down-regulated by Akt- mediated phosphorylation and nuclear exclusion of FoxO1 in insulin-stimulated skeletal muscle
    Robert J Southgate
    Cellular and Molecular Metabolism Laboratory, RMIT University, Bundoora, Victoria, Australia
    FASEB J 19:2072-4. 2005
    ..We conclude that insulin decreases the expression of genes involved in oxidative metabolism in healthy but not insulin resistant muscle, due to a decrease in FoxO1 phosphorylation and nuclear exclusion secondary to reduced Akt activity...
  38. ncbi Altering dietary nutrient intake that reduces glycogen content leads to phosphorylation of nuclear p38 MAP kinase in human skeletal muscle: association with IL-6 gene transcription during contraction
    M H Stanley Chan
    Skeletal Muscle Research Laboratory, School of Medical Sciences, Royal Melbourne Institute of Technology, Bundoora, Victoria, Australia
    FASEB J 18:1785-7. 2004
    ..Furthermore, phosphorylation of p38 MAPK in the nucleus appears to be an upstream target for IL-6, providing new insights into the regulation of IL-6 gene transcription...
  39. ncbi Rosiglitazone enhances glucose tolerance by mechanisms other than reduction of fatty acid accumulation within skeletal muscle
    Sarah J Lessard
    Exercise Metabolism Group, RMIT University School of Medical Sciences, Bundoora, Victoria, Australia
    Endocrinology 145:5665-70. 2004
    ..Our data suggest, therefore, that rosiglitazone enhances glucose tolerance by mechanisms other than reduction of fatty acid accumulation within skeletal muscle...
  40. ncbi Chronic rosiglitazone treatment restores AMPKalpha2 activity in insulin-resistant rat skeletal muscle
    Sarah J Lessard
    School of Medical Sciences, RMIT University, Melbourne, Victoria, Australia
    Am J Physiol Endocrinol Metab 290:E251-7. 2006
    ..ACC phosphorylation was decreased with obesity (P < 0.05) but restored to the level of lean controls with RSG treatment. Our data demonstrate that RSG restores AMPK signaling in skeletal muscle of insulin-resistant obese Zucker rats...
  41. ncbi Regulation of HSL serine phosphorylation in skeletal muscle and adipose tissue
    Matthew J Watt
    Cellular and Molecular Metabolism Laboratory, School of Medical Sciences, RMIT University, PO Box 71, Bundoora 3083, Victoria, Australia
    Am J Physiol Endocrinol Metab 290:E500-8. 2006
    ..Taken together, these data indicate that HSL activity is maintained in the face of AMPK activation as a result of elevated HSL Ser(660) phosphorylation in adipose tissue but not skeletal muscle...
  42. doi Metabolic remodeling in adipocytes promotes ciliary neurotrophic factor-mediated fat loss in obesity
    Seamus Crowe
    St Vincent s Institute of Medical Research and the Department of Medicine, The University of Melbourne, Fitzroy, Victoria 3065, Australia
    Endocrinology 149:2546-56. 2008
    ..We conclude that CNTF reprograms adipose tissue to promote mitochondrial biogenesis, enhancing oxidative capacity and reducing lipogenic capacity, thereby resulting in triglyceride loss...
  43. ncbi Ciliary neurotrophic factor suppresses hypothalamic AMP-kinase signaling in leptin-resistant obese mice
    Gregory R Steinberg
    St Vincent s Institute, 9 Princes Street, Fitzroy, Victoria 3065, Australia
    Endocrinology 147:3906-14. 2006
    ..A HFD blunted leptin but not CNTF effects on AMPK signaling in the ARC and PVN. In summary, these data demonstrate that CNTF(Ax15) bypasses diet-induced leptin resistance to reduce hypothalamic AMPK activity...
  44. doi Fluxing the mitochondria to insulin resistance
    Matthew J Watt
    St Vincent s Institute of Medical Research, Fitzroy, Victoria, Australia
    Cell Metab 7:5-6. 2008
    ....
  45. pmc Macrophage PPAR gamma is required for normal skeletal muscle and hepatic insulin sensitivity and full antidiabetic effects of thiazolidinediones
    Andrea L Hevener
    Department of Medicine, Division of Endocrinology and Metabolism, UCSD, La Jolla, California, USA
    J Clin Invest 117:1658-69. 2007
    ..These findings reveal an essential role of PPAR gamma in macrophages for the maintenance of whole-body insulin action and in mediating the antidiabetic actions of TZDs...
  46. ncbi Tumor necrosis factor alpha-induced skeletal muscle insulin resistance involves suppression of AMP-kinase signaling
    Gregory R Steinberg
    St Vincent s Institute and Department of Medicine, University of Melbourne, Fitzroy, Vic, 3065, Australia
    Cell Metab 4:465-74. 2006
    ..Our data demonstrate that AMPK is an important TNFalpha signaling target and is a contributing factor to the suppression of fatty-acid oxidation and the development of lipid-induced insulin resistance in obesity...
  47. doi Regulation and function of triacylglycerol lipases in cellular metabolism
    Matthew J Watt
    Department of Physiology, Monash University, Clayton, VIC 3800, Australia
    Biochem J 414:313-25. 2008
    ..In the present review, we discuss the metabolic regulation and function of TAG lipases with a focus on HSL (hormone-sensitive lipase), ATGL (adipose triacylglycerol lipase) and newly identified members of the lipolytic proteome...