P H Watson

Summary

Affiliation: University of Western Ontario
Country: Canada

Publications

  1. ncbi request reprint Enhanced osteoblast development after continuous infusion of hPTH(1-84) in the rat
    P H Watson
    Department of Medicine, The University of Western Ontario and The Lawson Research Institute, St Joseph s Health Centre, London, Canada
    Bone 24:89-94. 1999
  2. ncbi request reprint Nuclear localization of the type 1 parathyroid hormone/parathyroid hormone-related peptide receptor in MC3T3-E1 cells: association with serum-induced cell proliferation
    P H Watson
    Department of Medicine, University of Western Ontario and The Lawson Research Institute, London, Canada
    Bone 26:221-5. 2000
  3. ncbi request reprint Histomorphometric evidence for increased bone turnover without change in cortical thickness or porosity after 2 years of cyclical hPTH(1-34) therapy in women with severe osteoporosis
    A B Hodsman
    Department of Medicine and Lawson Research Institute, University of Western Ontario, London, ON, Canada
    Bone 27:311-8. 2000
  4. ncbi request reprint Comparison of the biochemical responses to human parathyroid hormone-(1-31)NH2 and hPTH-(1-34) in healthy humans
    L J Fraher
    Department of Medicine, The Lawson Research Institute, St Joseph s Health Center, University of Western Ontario, London, Canada
    J Clin Endocrinol Metab 84:2739-43. 1999
  5. ncbi request reprint Assessment of maintenance therapy with reduced doses of PTH(1-34) in combination with a raloxifene analogue (LY117018) following anabolic therapy in the ovariectomized rat
    A B Hodsman
    Department of Medicine, Lawson Research Institute, University of Western Ontario, London, Canada
    Bone 24:451-5. 1999
  6. ncbi request reprint Expression of PTHrP and PTHR (PTH/PTHrP-r) mRNAs and polypeptides in bovine ovary and stimulation of bovine blastocyst development in vitro following PTHrP treatment during oocyte maturation
    P H Watson
    Department of Medicine, The University of Western Ontario, and the Lawson Research Institute, London, Canada
    Anat Embryol (Berl) 203:175-84. 2001
  7. ncbi request reprint Suppression in gonadotropes of gonadotropin-releasing hormone-stimulated follicle-stimulating hormone release by the gonadal- and neurosteroid 3 alpha-hydroxy-4-pregnen-20-one involves cytosolic calcium
    J P Wiebe
    Hormonal Regulatory Mechanisms Laboratory, University of Western Ontario, London, Canada
    Endocrinology 134:377-82. 1994
  8. pmc Expression of the hypoxia-inducible and tumor-associated carbonic anhydrases in ductal carcinoma in situ of the breast
    C C Wykoff
    Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, United Kingdom
    Am J Pathol 158:1011-9. 2001
  9. ncbi request reprint Regulation of growth and tumorigenicity of breast cancer cells by the low molecular weight GTPase Rad and nm23
    Y H Tseng
    Joslin Diabetes Center, Department of Medicine, Harvard Medical School, Boston, Massachusetts 02215, USA
    Cancer Res 61:2071-9. 2001
  10. pmc Psoriasin (S100A7) expression and invasive breast cancer
    S Al-Haddad
    Department of Pathology University of Manitoba, Faculty of Medicine, Winnipeg, Manitoba, Canada
    Am J Pathol 155:2057-66. 1999

Collaborators

  • G N Hendy
  • A J Watson
  • J P Wiebe
  • Y Huang
  • J F Whitfield
  • P Morley
  • Anthony Hodsman
  • C C Wykoff
  • J Pastorek
  • A L Harris
  • K J Turner
  • P Ratcliffe
  • Y H Tseng
  • N J Beasley
  • Y Niu
  • L J Fraher
  • S Al-Haddad
  • D Cranston
  • R Poulsom
  • J P Crew
  • P J Ratcliffe
  • J S Moyers
  • S K Chia
  • R Leek
  • W S Sly
  • G J Cox
  • R English
  • J Zhu
  • D Vicent
  • N Beasley
  • L Campo
  • H Turley
  • C R Kahn
  • A Adeyinka
  • K Gatter
  • A Huang
  • K Hole
  • R Avram
  • Z Zhang
  • L C Murphy
  • J E Henderson
  • T Hiller-Hitchcock
  • L Snell
  • K L Chong
  • D Goltzman
  • E Leygue
  • G E Willick

Detail Information

Publications12

  1. ncbi request reprint Enhanced osteoblast development after continuous infusion of hPTH(1-84) in the rat
    P H Watson
    Department of Medicine, The University of Western Ontario and The Lawson Research Institute, St Joseph s Health Centre, London, Canada
    Bone 24:89-94. 1999
    ....
  2. ncbi request reprint Nuclear localization of the type 1 parathyroid hormone/parathyroid hormone-related peptide receptor in MC3T3-E1 cells: association with serum-induced cell proliferation
    P H Watson
    Department of Medicine, University of Western Ontario and The Lawson Research Institute, London, Canada
    Bone 26:221-5. 2000
    ..These data suggest an important role for the PTHR in the nucleus of MC3T3-E1 cells at the time of DNA synthesis and mitosis...
  3. ncbi request reprint Histomorphometric evidence for increased bone turnover without change in cortical thickness or porosity after 2 years of cyclical hPTH(1-34) therapy in women with severe osteoporosis
    A B Hodsman
    Department of Medicine and Lawson Research Institute, University of Western Ontario, London, ON, Canada
    Bone 27:311-8. 2000
    ....
  4. ncbi request reprint Comparison of the biochemical responses to human parathyroid hormone-(1-31)NH2 and hPTH-(1-34) in healthy humans
    L J Fraher
    Department of Medicine, The Lawson Research Institute, St Joseph s Health Center, University of Western Ontario, London, Canada
    J Clin Endocrinol Metab 84:2739-43. 1999
    ..However, at the doses employed, it does not increase serum calcium, is a weaker stimulator of the 25-hydroxyvitamin D-1alpha-hydroxylase, and does not induce rapid bone resorption...
  5. ncbi request reprint Assessment of maintenance therapy with reduced doses of PTH(1-34) in combination with a raloxifene analogue (LY117018) following anabolic therapy in the ovariectomized rat
    A B Hodsman
    Department of Medicine, Lawson Research Institute, University of Western Ontario, London, Canada
    Bone 24:451-5. 1999
    ....
  6. ncbi request reprint Expression of PTHrP and PTHR (PTH/PTHrP-r) mRNAs and polypeptides in bovine ovary and stimulation of bovine blastocyst development in vitro following PTHrP treatment during oocyte maturation
    P H Watson
    Department of Medicine, The University of Western Ontario, and the Lawson Research Institute, London, Canada
    Anat Embryol (Berl) 203:175-84. 2001
    ..The results suggest that granulosa cells may be a primary site of PTHrP production and release. Oocytes from all follicular stages stained strongly for PTHrP polypeptides and PTHrP enhanced development to the blastocyst stage in vitro...
  7. ncbi request reprint Suppression in gonadotropes of gonadotropin-releasing hormone-stimulated follicle-stimulating hormone release by the gonadal- and neurosteroid 3 alpha-hydroxy-4-pregnen-20-one involves cytosolic calcium
    J P Wiebe
    Hormonal Regulatory Mechanisms Laboratory, University of Western Ontario, London, Canada
    Endocrinology 134:377-82. 1994
    ..The consistent decrease in total FSH (released plus cellular content) by 3 alpha HP suggests that this neurosteroid may also suppress FSH synthesis...
  8. pmc Expression of the hypoxia-inducible and tumor-associated carbonic anhydrases in ductal carcinoma in situ of the breast
    C C Wykoff
    Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, United Kingdom
    Am J Pathol 158:1011-9. 2001
    ..The existence of differential regulation and associations with an aggressive phenotype may be important in the development of selective inhibitors of CAs, because the latter have recently been shown to prevent tumor invasion...
  9. ncbi request reprint Regulation of growth and tumorigenicity of breast cancer cells by the low molecular weight GTPase Rad and nm23
    Y H Tseng
    Joslin Diabetes Center, Department of Medicine, Harvard Medical School, Boston, Massachusetts 02215, USA
    Cancer Res 61:2071-9. 2001
    ..These findings suggest that Rad may act as an oncogenic protein in breast tissues and demonstrate a potential mechanism by which interaction between Rad and nm23 may regulate growth and tumorigenicity of breast cancer...
  10. pmc Psoriasin (S100A7) expression and invasive breast cancer
    S Al-Haddad
    Department of Pathology University of Manitoba, Faculty of Medicine, Winnipeg, Manitoba, Canada
    Am J Pathol 155:2057-66. 1999
    ..0022). These results suggest that psoriasin may be a marker of aggressive behavior in invasive tumors and are consistent with a function as a chemotactic factor...
  11. ncbi request reprint Carbonic anhydrase IX, an endogenous hypoxia marker, expression in head and neck squamous cell carcinoma and its relationship to hypoxia, necrosis, and microvessel density
    N J Beasley
    Oxford Centre for Head and Neck Oncology, Radcliffe Infirmary, Oxford OX2 6HE, United Kingdom
    Cancer Res 61:5262-7. 2001
    ..Overexpression may help to maintain the intracellular pH, giving tumor cells a survival advantage and enhancing resistance to radiotherapy and chemotherapy. CA IX is a potential target for future therapy in HNSCC...
  12. pmc The hypoxia-inducible genes VEGF and CA9 are differentially regulated in superficial vs invasive bladder cancer
    K J Turner
    ICRF Molecular Oncology Laboratory and Angiogenesis Group, Institute of Molecular Medicine, John Radcliffe Hospital, Oxford OX3 9DU, UK
    Br J Cancer 86:1276-82. 2002
    ..The expression of CA IX on the luminal surface justifies investigation of its utility as a therapeutic target/prognostic indicator...