P H Watson
Affiliation: University of Western Ontario
- Enhanced osteoblast development after continuous infusion of hPTH(1-84) in the ratP H Watson
Department of Medicine, The University of Western Ontario and The Lawson Research Institute, St Joseph s Health Centre, London, Canada
Bone 24:89-94. 1999....
- Nuclear localization of the type 1 parathyroid hormone/parathyroid hormone-related peptide receptor in MC3T3-E1 cells: association with serum-induced cell proliferationP H Watson
Department of Medicine, University of Western Ontario and The Lawson Research Institute, London, Canada
Bone 26:221-5. 2000..These data suggest an important role for the PTHR in the nucleus of MC3T3-E1 cells at the time of DNA synthesis and mitosis...
- Histomorphometric evidence for increased bone turnover without change in cortical thickness or porosity after 2 years of cyclical hPTH(1-34) therapy in women with severe osteoporosisA B Hodsman
Department of Medicine and Lawson Research Institute, University of Western Ontario, London, ON, Canada
Bone 27:311-8. 2000....
- Comparison of the biochemical responses to human parathyroid hormone-(1-31)NH2 and hPTH-(1-34) in healthy humansL J Fraher
Department of Medicine, The Lawson Research Institute, St Joseph s Health Center, University of Western Ontario, London, Canada
J Clin Endocrinol Metab 84:2739-43. 1999..However, at the doses employed, it does not increase serum calcium, is a weaker stimulator of the 25-hydroxyvitamin D-1alpha-hydroxylase, and does not induce rapid bone resorption...
- Assessment of maintenance therapy with reduced doses of PTH(1-34) in combination with a raloxifene analogue (LY117018) following anabolic therapy in the ovariectomized ratA B Hodsman
Department of Medicine, Lawson Research Institute, University of Western Ontario, London, Canada
Bone 24:451-5. 1999....
- Expression of PTHrP and PTHR (PTH/PTHrP-r) mRNAs and polypeptides in bovine ovary and stimulation of bovine blastocyst development in vitro following PTHrP treatment during oocyte maturationP H Watson
Department of Medicine, The University of Western Ontario, and the Lawson Research Institute, London, Canada
Anat Embryol (Berl) 203:175-84. 2001..The results suggest that granulosa cells may be a primary site of PTHrP production and release. Oocytes from all follicular stages stained strongly for PTHrP polypeptides and PTHrP enhanced development to the blastocyst stage in vitro...
- Suppression in gonadotropes of gonadotropin-releasing hormone-stimulated follicle-stimulating hormone release by the gonadal- and neurosteroid 3 alpha-hydroxy-4-pregnen-20-one involves cytosolic calciumJ P Wiebe
Hormonal Regulatory Mechanisms Laboratory, University of Western Ontario, London, Canada
Endocrinology 134:377-82. 1994..The consistent decrease in total FSH (released plus cellular content) by 3 alpha HP suggests that this neurosteroid may also suppress FSH synthesis...
- Expression of the hypoxia-inducible and tumor-associated carbonic anhydrases in ductal carcinoma in situ of the breastC C Wykoff
Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, United Kingdom
Am J Pathol 158:1011-9. 2001..The existence of differential regulation and associations with an aggressive phenotype may be important in the development of selective inhibitors of CAs, because the latter have recently been shown to prevent tumor invasion...
- Regulation of growth and tumorigenicity of breast cancer cells by the low molecular weight GTPase Rad and nm23Y H Tseng
Joslin Diabetes Center, Department of Medicine, Harvard Medical School, Boston, Massachusetts 02215, USA
Cancer Res 61:2071-9. 2001..These findings suggest that Rad may act as an oncogenic protein in breast tissues and demonstrate a potential mechanism by which interaction between Rad and nm23 may regulate growth and tumorigenicity of breast cancer...
- Psoriasin (S100A7) expression and invasive breast cancerS Al-Haddad
Department of Pathology University of Manitoba, Faculty of Medicine, Winnipeg, Manitoba, Canada
Am J Pathol 155:2057-66. 1999..0022). These results suggest that psoriasin may be a marker of aggressive behavior in invasive tumors and are consistent with a function as a chemotactic factor...
- Carbonic anhydrase IX, an endogenous hypoxia marker, expression in head and neck squamous cell carcinoma and its relationship to hypoxia, necrosis, and microvessel densityN J Beasley
Oxford Centre for Head and Neck Oncology, Radcliffe Infirmary, Oxford OX2 6HE, United Kingdom
Cancer Res 61:5262-7. 2001..Overexpression may help to maintain the intracellular pH, giving tumor cells a survival advantage and enhancing resistance to radiotherapy and chemotherapy. CA IX is a potential target for future therapy in HNSCC...
- The hypoxia-inducible genes VEGF and CA9 are differentially regulated in superficial vs invasive bladder cancerK J Turner
ICRF Molecular Oncology Laboratory and Angiogenesis Group, Institute of Molecular Medicine, John Radcliffe Hospital, Oxford OX3 9DU, UK
Br J Cancer 86:1276-82. 2002..The expression of CA IX on the luminal surface justifies investigation of its utility as a therapeutic target/prognostic indicator...